CN107535540A - A kind of antiseptic and preparation method thereof - Google Patents
A kind of antiseptic and preparation method thereof Download PDFInfo
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- CN107535540A CN107535540A CN201710738661.8A CN201710738661A CN107535540A CN 107535540 A CN107535540 A CN 107535540A CN 201710738661 A CN201710738661 A CN 201710738661A CN 107535540 A CN107535540 A CN 107535540A
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Abstract
The invention discloses a kind of antiseptic, including titanium dioxide, folium artemisiae argyi, granatum, purslane, plants essential oil, allicin, sodium Diacetate, emulsifying agent, stabilizer, ethanol and purified water.A kind of antiseptic proposed by the present invention, the antiseptic include titanium dioxide and sodium Diacetate, while also added a variety of natural antibacterial ingredients, have no side effect safely, and the compounding use of more heavy constituents has good antibiotic and sterilizing effect；In addition the plants essential oil added can adjust the respiratory system and integumentary system of human body, improve immunity of organisms.It the experiment proved that, disinfection antibacterial agent produced by the present invention has the excellent in performance of rapid-action antibacterial time length, to Escherichia coli, Candida albicans, staphylococcus aureus, shigella dysenteriae, aspergillus flavus are had into significant inhibitory action.
Description
Technical field
The present invention relates to daily chemical product technical field, more particularly to a kind of antiseptic and preparation method thereof.
Background technology
With the popularization of health knowledge, the consciousness that the sterilization of people is antibacterial is more and more stronger；Air is the main of transmission
One of medium, especially contain various bacteria in the room air of the public places such as hospital, market, eating and drinking establishment, human body is produced
Raw greatly harm, conventional air sterilization technique have ultraviolet, plasma air purification and chemosterilant；Wherein chemistry disappears
Toxic agent includes chloride class disinfectant, peroxide sterilants, quaternary ammonium disinfectant, biguanides disinfectant etc., but due to chemistry
Product has stronger toxic side effect, and the health of human body can be exerted an adverse impact.
In order to avoid the harmful effect that chemical classes disinfection antibacterial agent is brought, many Research tendencies are in pure Chinese medicine composition at present
Antiseptic, Chinese patent, application publication number：CN 103875724A, patent name：A kind of air sanitizer, the disinfectant use
Herba Artemisiae Scopariae, folium artemisiae argyi, cayropteris incana, wolf's milk, folium isatidis, eupatorium, frutus cnidii, honeysuckle, peppermint compounding form.Though the patent using
Pure Chinese medicine component is safe and non-stimulating, but its stability is poor, the defects of certain be present to the sterilizing ability of public place.
The content of the invention
Based on technical problem existing for background technology, the present invention, which proposes, provides a kind of antiseptic, has well antibacterial
Effect.
A kind of antiseptic, including following component in parts by weight：Titanium dioxide 2-7 parts, folium artemisiae argyi 10-20 parts, pomegranate
Skin 5-12 parts, purslane 5-12 parts, plants essential oil 5-10 parts, emulsifying agent 0.5-1.0 parts, stabilizer 1.2-1.8 parts, ethanol 30-
50 parts, purified water 30-40 parts.
Preferably, the component of following parts by weight meter is included：Allicin 7-15 parts.
Preferably, the component of following parts by weight meter is included：Sodium Diacetate 2-10 parts.
Preferably, the concentration of the ethanol is 30-40%.
Preferably, the plants essential oil is one in cinnamon essential oil, thyme essential oil, lemon grass (Cymbopogon citratus) essential oil, Geranium Essential
Kind is a variety of.
Preferably, the emulsifying agent is polyethylene glycol, dodecyl sodium sulfate or aliphatic acid polyethenoxy ether.
Preferably, the stabilizer is sodium metasilicate, magnesium silicate or sodium citrate.
A kind of preparation method of antiseptic, method and step are as follows：S1：By folium artemisiae argyi, granatum, purslane crushed after being dried,
Cross 100-120 mesh sieves；S2：Powder made from S1 and ethanol are put into agitator tank, stirring at low speed 2-3h；S3：By made from S2
Mixed material filters, and stays clarified solution；S4：Purified water, titanium dioxide, sodium Diacetate, stably are added into clarified solution made from S3
Agent, it is well mixed；S5：Allicin, plants essential oil, emulsifying agent are added into S4, is well mixed, produces.
Further, the mixing speed of the S2 is 100-150rpm, and whipping temp is 70-80 DEG C.
A kind of composition proposed by the present invention is used for disinfection antibacterial agent in preparation room.
Feature component：
Titanium dioxide crystal can just kill the microorganism being in contact with it completely under light irradiation in the short time, have and see
The advantages that imitating fast, durable, non-secondary pollution；Titanium dioxide can form OH freedom on its surface after ultraviolet light wave is absorbed
Base, its Strong oxdiative ability can make organic matter whole oxidative degradation, including penetrate, destroy membrane structure, make bacterium, virus point
Solution, toxin caused by and can degradation of cell.
Sodium Diacetate is a kind of efficient, broad-spectrum antibacterial and anti-mildew agent, especially has stronger inhibitory action to aflatoxins；It
By permeating microorganism wall, the generation of various enzyme systems in interference cell, it can efficiently suppress more than ten kinds of moldin and more
The growth and sprawling of kind bacterium.
The main chemical compositions of folium artemisiae argyi have volatile oil, flavones, eudesmane, triterpenes and trace element, wherein in volatile oil
Containing predominantly ɑ-thujene, firpene, amphene, sabinene, 1-OCOL, 1, 8-Cineole, γ-terpinene, camphor, borneol
Deng.Folium artemisiae argyi is double to bacillus anthracis, Alpha-hemolytic streptococcus, Beta-hemolytic streptococcus, corynebacterium diphtheriae, bacillus pseudodiphthericus, lung class in vitro
10 kinds of thermophilic gas of Gram-positive such as coccus, staphylococcus aureus, Staphylococcus citreus, staphylococcus aureus, hay bacillus
Bacterium all has antibacterial action.
Contain a variety of alkaloids in granatum, bacteriostatic test confirms, the alcohol extract and pericarp water decoction of pomegranate, has wide
Antibacterial action is composed, it has obvious suppression to make to staphylococcus aureus, hemolytic streptococcus, comma bacillus, shigella dysenteriae etc.
With wherein most strong to Shigella shigae effect, granatum flooding agent in vitro also has different journeys to various dermatophytes
The inhibitory action of degree.
Containing a variety of flavones, alkaloid, Triterpenoidss, organic acid, catecholamine etc. in purslane；Modern pharmacological research shows,
Purslane has broad-spectrum antibacterial action, has stronger inhibitory action to Escherichia coli, shigella dysenteriae, typhoid bacillus etc., especially
It is to have to pretend very much use to shigella dysenteriae.
Allicin is three thio-allyl ether class compounds, is naturally occurring in the bulb of liliaceous plant garlic.To a variety of
Gram-positive and negative bacterium have an antibacterial action, and allicin can suppress shigella dysenteriae, typhoid bacillus breeding, to staphylococcus,
Pneumococcus etc. has obvious suppression to kill effect.
Compared with prior art, the device have the advantages that being：
A kind of antiseptic proposed by the present invention, the antiseptic include titanium dioxide and sodium Diacetate, also added simultaneously
A variety of natural antibacterial ingredients, have no side effect safely, and the compounding use of more heavy constituents has good antibiotic and sterilizing effect；This explant
Thing essential oil is the extraction distinctive aromatic substance of plant, and molecule is small, it is easy to is absorbed by the body, and can permeate device in human body rapidly
Official, the respiratory system and integumentary system of human body are adjusted, improves immunity of organisms.It the experiment proved that, sterilization produced by the present invention
Antiseptic has the excellent in performance of rapid-action, antibacterial time length, to by Escherichia coli, Candida albicans, staphylococcus aureus,
Shigella dysenteriae, aspergillus flavus have significant inhibitory action.
Embodiment
The present invention is made with reference to specific embodiment further to explain.
Embodiment 1
A kind of antiseptic, including following component in parts by weight：2 parts of titanium dioxide, 10 parts of folium artemisiae argyi, 5 parts of granatum,
5 parts of purslane, 5 parts of plants essential oil, 7 parts of allicin, 2 parts of sodium Diacetate, 0.5 part of emulsifying agent, 1.2 parts of stabilizer, 30 parts of ethanol,
30 parts of purified water.
The concentration of ethanol is 30%；Plants essential oil is cinnamon essential oil；Emulsifying agent is polyethylene glycol；Stabilizer is sodium metasilicate.
A kind of preparation method of antiseptic, method and step are as follows：S1：By folium artemisiae argyi, granatum, purslane crushed after being dried,
Cross 100 mesh sieves；S2：Powder made from S1 and ethanol are put into agitator tank, mixing speed 100rpm, whipping temp 70
DEG C, mixing time 2h；S3：Mixed material made from S2 is filtered, stays clarified solution；S4：Added into clarified solution made from S3
Purified water, titanium dioxide, sodium Diacetate, stabilizer, it is well mixed；S5：Allicin, plants essential oil, emulsifying agent are added into S4,
It is well mixed, produce.
Embodiment 2
A kind of antiseptic, including following component in parts by weight：7 parts of titanium dioxide, 20 parts of folium artemisiae argyi, granatum 12
Part, 12 parts of purslane, 10 parts of plants essential oil, 15 parts of allicin, 10 parts of sodium Diacetate, 1.0 parts of emulsifying agent, 1.8 parts of stabilizer, second
50 parts of alcohol, 40 parts of purified water.
The concentration of ethanol is 40%；Plants essential oil is thyme essential oil；Emulsifying agent is dodecyl sodium sulfate；Stabilizer is
Magnesium silicate.
A kind of preparation method of antiseptic, method and step are as follows：S1：By folium artemisiae argyi, granatum, purslane crushed after being dried,
Cross 120 mesh sieves；S2：Powder made from S1 and ethanol are put into agitator tank, mixing speed 150rpm, whipping temp 80
DEG C, mixing time 3h；S3：Mixed material made from S2 is filtered, stays clarified solution；S4：Added into clarified solution made from S3
Purified water, titanium dioxide, sodium Diacetate, stabilizer, it is well mixed；S5：Allicin, plants essential oil, emulsifying agent are added into S4,
It is well mixed, produce.
Embodiment 3
A kind of antiseptic, including following component in parts by weight：3 parts of titanium dioxide, 15 parts of folium artemisiae argyi, 7 parts of granatum,
9 parts of purslane, 6 parts of plants essential oil, 10 parts of allicin, 4 parts of sodium Diacetate, 0.9 part of emulsifying agent, 1.5 parts of stabilizer, ethanol 40
Part, 35 parts of purified water.
The concentration of ethanol is 35%；Plants essential oil is lemon grass (Cymbopogon citratus) essential oil；Emulsifying agent is aliphatic acid polyethenoxy ether；Stabilizer
For sodium citrate.
A kind of preparation method of antiseptic, method and step are as follows：S1：By folium artemisiae argyi, granatum, purslane crushed after being dried,
Cross 120 mesh sieves；S2：Powder made from S1 and ethanol are put into agitator tank, mixing speed 130rpm, whipping temp 75
DEG C, mixing time 2.5h；S3：Mixed material made from S2 is filtered, stays clarified solution；S4：Add into clarified solution made from S3
Enter purified water, titanium dioxide, sodium Diacetate, stabilizer, be well mixed；S5：Allicin, plants essential oil, emulsification are added into S4
Agent, it is well mixed, produces.
Embodiment 4
A kind of antiseptic, including following component in parts by weight：6 parts of titanium dioxide, 18 parts of folium artemisiae argyi, 8 parts of granatum,
11 parts of purslane, 7 parts of plants essential oil, 8 parts of allicin, 6 parts of sodium Diacetate, 0.8 part of emulsifying agent, 1.7 parts of stabilizer, ethanol 35
Part, 37 parts of purified water.
The concentration of ethanol is 38%；Plants essential oil is Geranium Essential；Emulsifying agent is polyethylene glycol；Stabilizer is silicic acid
Sodium.
A kind of preparation method of antiseptic, method and step are as follows：S1：By folium artemisiae argyi, granatum, purslane crushed after being dried,
Cross 110 mesh sieves；S2：Powder made from S1 and ethanol are put into agitator tank, mixing speed 120rpm, whipping temp 73
DEG C, mixing time 2h；S3：Mixed material made from S2 is filtered, stays clarified solution；S4：Added into clarified solution made from S3
Purified water, titanium dioxide, sodium Diacetate, stabilizer, it is well mixed；S5：Allicin, plants essential oil, emulsifying agent are added into S4,
It is well mixed, produce.
Embodiment 5
A kind of antiseptic, including following component in parts by weight：5 parts of titanium dioxide, 12 parts of folium artemisiae argyi, granatum 10
Part, 6 parts of purslane, 9 parts of plants essential oil, 12 parts of allicin, 8 parts of sodium Diacetate, 0.6 part of emulsifying agent, 1.3 parts of stabilizer, ethanol
45 parts, 33 parts of purified water.
The concentration of ethanol is 32%.Plants essential oil is cinnamon essential oil and thyme essential oil in mass ratio 2：1 prepares；Emulsifying agent
For polyethylene glycol；Stabilizer is sodium citrate.
A kind of preparation method of antiseptic, method and step are as follows：S1：By folium artemisiae argyi, granatum, purslane crushed after being dried,
Cross 100 mesh sieves；S2：Powder made from S1 and ethanol are put into agitator tank, mixing speed 110rpm, whipping temp 77
DEG C, mixing time 3h；S3：Mixed material made from S2 is filtered, stays clarified solution；S4：Added into clarified solution made from S3
Purified water, titanium dioxide, sodium Diacetate, stabilizer, it is well mixed；S5：Allicin, plants essential oil, emulsifying agent are added into S4,
It is well mixed, produce.
Properties of product detect
First, air sterillization antibacterial experiment
1st, test method：Experimental method is with reference to GB/T 18204.1-2000.
2nd, result of the test：It is shown in Table 1.
The anti-bacteria test result of table 1
Control group is commercially available indoor disinfectant.
Conclusion：Compared with control group, disinfection antibacterial agent produced by the present invention has rapid-action, the Optimality of antibacterial time length
Energy.
2nd, anti-microbial property test
1st, experimental method：Escherichia coli, Candida albicans, staphylococcus aureus and shigella dysenteriae are cultivated to logarithm
Phase, 10 are diluted to culture medium5-106CFU/mL, the bacterium solution of dilution is evenly coated on solid medium using spreader.Training
Foster primary surface vertically puts Oxford cup, and measuring samples are added in cup, is cultivated 16-18 hours at 37 DEG C after filling it up with, rear using trip
Mark kind of calliper antibacterial circle diameter.
2nd, testing result：It is shown in Table 2.
The anti-bacteria test result of table 2
Note："+" represents that part is antibacterial, it can be seen that antibacterial ring size, but still have part colony growth in ring；" ++ " represents obvious suppression
Bacterium, there is an obvious antibacterial ring size, without bacterium colony in ring.
Conclusion：From table 2, disinfection antibacterial agent produced by the present invention is to by Escherichia coli, Candida albicans, golden yellow Portugal
Grape coccus, shigella dysenteriae and aspergillus flavus have significant inhibitory action.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (10)
1. a kind of antiseptic, it is characterised in that including following component in parts by weight：Titanium dioxide 2-7 parts, folium artemisiae argyi 10-
20 parts, granatum 5-12 parts, purslane 5-12 parts, plants essential oil 5-10 parts, emulsifying agent 0.5-1.0 parts, stabilizer 1.2-1.8
Part, ethanol 30-50 parts, purified water 30-40 parts.
2. a kind of antiseptic according to claim 1, it is characterised in that also include the component of following parts by weight meter：Garlic
Plain 7-15 parts.
3. a kind of antiseptic according to claim 1, it is characterised in that also include the component of following parts by weight meter：Double second
Sour sodium 2-10 parts.
4. a kind of antiseptic according to claim 1, it is characterised in that the concentration of the ethanol is 30-40%.
5. a kind of antiseptic according to claim 1, it is characterised in that the plants essential oil is cinnamon essential oil, thyme
One or more in essential oil, lemon grass (Cymbopogon citratus) essential oil, Geranium Essential.
6. a kind of antiseptic according to claim 1, it is characterised in that the emulsifying agent is polyethylene glycol, dodecyl
Sodium sulfonate or aliphatic acid polyethenoxy ether.
7. a kind of antiseptic according to claim 1, it is characterised in that the stabilizer is sodium metasilicate, magnesium silicate or lemon
Lemon acid sodium.
8. the preparation method of a kind of antiseptic according to claim any one of 1-7, it is characterised in that method and step is such as
Under：S1：By folium artemisiae argyi, granatum, purslane crushed after being dried, 100-120 mesh sieves are crossed；S2：Powder made from S1 and ethanol are put
Enter in agitator tank, stirring at low speed 2-3h；S3：Mixed material made from S2 is filtered, stays clarified solution；S4：To clarification made from S3
Purified water, titanium dioxide, sodium Diacetate, stabilizer are added in liquid, is well mixed；S5：Allicin, plant essence are added into S4
Oil, emulsifying agent, it is well mixed, produces.
9. the preparation method of a kind of antiseptic according to claim 8, it is characterised in that the mixing speed of the S2 is
100-150rpm, whipping temp are 70-80 DEG C.
10. the composition described in claim any one of 1-7 is used for disinfection antibacterial agent in preparation room.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111642524A (en) * | 2019-08-09 | 2020-09-11 | 天津绿木鸿涛科技有限公司 | Disinfecting antibacterial agent |
| CN111903709A (en) * | 2020-08-11 | 2020-11-10 | 北京锦绣新技术发展有限公司 | Preparation method of sterilizing disinfectant for killing coronavirus |
| CN114568429A (en) * | 2022-03-29 | 2022-06-03 | 浙江绿岛科技有限公司 | Bacteriostatic and mildewproof aerosol based on self-film forming and preparation method thereof |
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