CN110327222B - Purely natural plant essential oil sterilization and disinfection wet tissue and preparation method thereof - Google Patents
Purely natural plant essential oil sterilization and disinfection wet tissue and preparation method thereof Download PDFInfo
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Abstract
The pure natural plant essential oil sterilization and disinfection wet tissue consists of dust-free paper and wet tissue liquid, wherein the wet tissue liquid consists of the following raw materials in parts by weight: ethanol: 3% -5% of rhizoma atractylodis volatile oil: 1.0-1.5 percent of cassia twig volatile oil: 0.8% -1.2%, cocoamide DEA:0.5% -1.0%, sodium lauryl ether sulfate: 3% -4%, TEA dodecyl sulfate: 2.0% -3.0%, propylene glycol: 5% -8%, purified water: and the balance. The disinfectant wet tissue can efficiently sterilize and disinfect, can quickly kill various viruses and germs on the surface of a human body or objects by wiping, is nontoxic and harmless to the human body, and has the characteristics of convenient carrying, long-term storage and low price.
Description
Technical Field
The invention relates to a purely natural plant essential oil sterilization and disinfection wet tissue, in particular to a sterilization and disinfection wet tissue rich in rhizoma atractylodis volatile oil and cassia twig volatile oil.
Background
The disinfection wet tissue is a disposable sanitary article and is mainly used in commercial and reception places such as civil aviation, hotels, restaurants, exhibitions and the like in the past. The portable wet tissue is accepted by consumers, is convenient to use, and has the function of cleaning stains at any time. With the improvement of living standard and the further cognition of people on 'cleaning', the thorough cleaning of visible stains and invisible bacteria becomes the real demand of people. Some consumer groups need to use the wet tissue to clean and disinfect tableware or baby bottle nipples, hands and mouths of babies and toys, residual liquid after the wet tissue is wiped is easily eaten by human bodies, and the health of the human bodies, particularly young babies and children, needs to be concerned. However, most of the wet tissues in the market have only a wiping function and do not have the disinfection and sterilization effects, and most of the domestic common medicaments for disinfecting tableware are chlorine-containing disinfectants. Therefore, the safe and nontoxic pure natural plant essential oil sterilization and disinfection wet tissue has very wide market prospect and economic value.
Rhizoma Atractylodis (Rhizoma Atractylodes lancea L.) is also called Atractylodes lancea L.which is dried rhizome of Atractylodes lancea L.lancea (Thunb.) DC. Or Atractylodes lancea L.DC. Of Atractylodes of Compositae, and Atractylodes lancea L.is also called Atractylodes lancea L.. The flavor is pungent and warm, and is specialized in spleen and stomach, and has the main functions of drying dampness and strengthening spleen, dispelling wind and removing dampness. The rhizoma Atractylodis is used for fumigating air, and has effects of resolving stagnation and avoiding filth, and its main bactericidal active component is volatile oil. The rhizoma atractylodis fumigation is applied to sickrooms, delivery rooms, operating rooms and the like to obtain satisfactory effects.
The cassia twig is a dry twig of cinnamon (cinnamomum cassia presl.) belonging to Lauraceae, and has the effects of sweating and expelling pathogenic factors from muscles, warming and activating channels, supporting yang and regulating qi, and calming the pulse and descending qi.
Disclosure of Invention
Aiming at the gap of the existing market, the invention provides the pure natural plant essential oil sterilization and disinfection wet tissue which has the characteristics of high-efficiency sterilization and disinfection, safety and no side effect. The sterilizing and disinfecting wet tissue liquid is prepared by screening and optimally combining a surfactant with good wetting and decontamination effects and Chinese herbal medicines with a sterilizing function, and through a composite technology, active components with the sterilizing function are stably and synergistically enhanced, and a disinfectant with the sterilizing function is prepared and is soaked in non-woven fabrics to prepare the sterilizing and disinfecting cleaning tissue.
The disinfection wet tissue disclosed by the invention consists of dust-free paper and wet tissue liquid, wherein the wet tissue liquid consists of the following raw materials in parts by weight: ethanol: 3% -5% of rhizoma atractylodis volatile oil: 1.0-1.5 percent of cassia twig volatile oil: 0.8% -1.2%, cocamide DEA:0.5% -1.0%, sodium lauryl ether sulfate: 3% -4%, TEA dodecyl sulfate: 2.0% -3.0%, propylene glycol: 5% -8%, purified water: and (4) the balance. Wherein DEA represents a diethylamino group and TEA represents a triethylamine group.
Preferably, the wet tissue liquid consists of the following raw materials in parts by weight: ethanol: 3% -5% of rhizoma atractylodis volatile oil: 1.0-1.2%, and cassia twig volatile oil: 0.8% -1.0%, cocamide DEA:0.5% -1.0%, sodium lauryl ether sulfate: 3% -4%, TEA dodecyl sulfate: 2.0% -3.0%, propylene glycol: 5% -8%, purified water: and (4) the balance.
The rhizoma atractylodis volatile oil in the raw materials is extracted from dried rhizome of rhizoma atractylodis lanceae or rhizoma atractylodis macrocephalae in the atractylodes of Compositae. The rhizoma Atractylodis volatile oil mainly contains volatile substances such as beta-eucalyptol, atractylodin, atractylone, atractylol, elemene oleyl alcohol, etc. Not only can kill mycobacterium tuberculosis, pseudomonas aeruginosa and the like in the air to a certain extent, but also has strong killing effect on escherichia coli and staphylococcus aureus. The cassia twig volatile oil in the raw materials is extracted from dry twigs of cinnamon of Lauraceae. The cassia twig volatile oil mainly contains volatile substances such as benzaldehyde, phenylpropyl aldehyde, trans-cinnamic aldehyde, cinnamic aldehyde and the like, and has remarkable antibacterial, sedative, analgesic and other effects. The action effects of atractylodes rhizome and cassia twig as common traditional Chinese medicines are recorded early in ancient times. However, the inventor firstly discovers in a large number of experiments that the main active components of atractylol and the like in the atractylodes volatile oil and the main active component of cinnamaldehyde and the like in the cassia twig volatile oil have synergistic effects, and the atractylol and the cinnamaldehyde are combined to reduce the dosage and simultaneously have obvious inhibition effects on staphylococcus aureus, escherichia coli and candida albicans.
In the concrete case, the rhizoma atractylodis volatile oil and the cassia twig volatile oil are prepared by adopting a steam distillation method: 1) And (3) rhizoma atractylodis oil: pulverizing rhizoma Atractylodis into dry powder, placing into a steam distillation extractor containing 10 times of water, controlling temperature at 100 deg.C (+ -5 deg.C), stopping extraction for about 6 hr when the liquid flowing down from the branch pipe of the extractor is colorless, removing lower part of distilled water with separating funnel to obtain oily crude extract, sealing, and storing in 4 deg.C refrigerator for use. 2) Cassia twig oil: pulverizing ramulus Cinnamomi into dry powder, placing into steam distillation extractor containing 12 times of water, controlling temperature at 100 deg.C (+ -5 deg.C), stopping extraction for about 6 hr when the liquid flowing down from branch pipe of the extractor is colorless, removing lower part of distilled water with separating funnel to obtain oily crude extract, sealing, and storing in refrigerator at 4 deg.C.
In particular, the rhizoma Atractylodis volatile oil and ramulus Cinnamomi volatile oil can also be supplemented with CO 2 Supercritical (or subcritical) fluid extraction method: 1) And (3) rhizoma atractylodis oil: pulverizing rhizoma Atractylodis to dryPulverizing, adding appropriate amount of CO 2 Supercritical CO is directly used in the supercritical fluid extraction tank 2 Extracting to obtain the final product. 2) Cassia twig oil: pulverizing ramulus Cinnamomi into dry powder, and adding appropriate amount of CO 2 Supercritical CO is directly used in the supercritical fluid extraction tank 2 Extracting to obtain the final product.
The disinfection wet tissue is prepared by taking the rhizoma atractylodis volatile oil and the cassia twig volatile oil as composite active ingredients, matching auxiliary ingredients such as a solvent, a surfactant and the like, preparing a disinfection solution (wet tissue solution) according to a proper proportion, and soaking or spraying a paper towel in the disinfection solution. The preparation method comprises the following specific steps: mixing purified water and ethanol uniformly, adding Cocoamide DEA, sodium lauryl ether sulfate, TEA dodecyl sulfate and propylene glycol respectively, stirring to dissolve completely, adding rhizoma Atractylodis oil and ramulus Cinnamomi oil, mechanically stirring to dissolve completely to transparent and clear state, adding active carbon, stirring completely to adsorb and decolorize, and filtering to obtain supernatant to obtain the disinfectant. And soaking or spraying the disinfectant and the wood pulp paper towel to obtain the disinfected paper towel.
In addition, during the preparation process, the inventor also discovers for the first time that if proper amounts of soda and baking soda are added, the dissolution of each component can be accelerated, and the layering of the two volatile oils can be prevented. The proper weight ratio is as follows: 0.4 to 0.5 percent of soda and 0.2 to 0.5 percent of baking soda.
According to the preferred aspect of the invention, the enhanced disinfectant wet tissue is also provided, and the enhanced disinfectant wet tissue consists of the following components in percentage by weight: ethanol: 3% -5% of rhizoma atractylodis volatile oil: 1.0-1.5 percent of cassia twig volatile oil: 0.8-1.2%, medicinal herb oil 0.1-0.3%, cocamide DEA:0.5% -1.0%, sodium lauryl ether sulfate: 3% -4%, TEA dodecyl sulfate: 2.0% -3.0%, propylene glycol: 5% -8%, purified water: and (4) the balance.
The preparation process of the traditional Chinese medicine qucao oil comprises the following steps: pulverizing medicinal herbs into dry powder, placing into a steam distillation extractor filled with 15 times of water, controlling temperature at 100 deg.C (+ -5 deg.C), stopping extraction when the liquid flowing down from the branch pipe of the extractor is colorless, removing lower part of distilled water with separating funnel to obtain oily crude extract, sealing, and storing in a refrigerator at 4 deg.C.
The inventor firstly finds that the addition of a small amount of medicinal herb oil can further shorten the killing time and improve the sterilization effect, which may be related to the synergistic effect brought by the permeability of the medicinal herb oil and the auxiliary sterilization performance of the medicinal herb oil.
The disinfectant wet tissue can efficiently sterilize and disinfect, can quickly kill various viruses and germs on the surface of a human body or an article through wiping, is nontoxic and harmless to the human body, has the characteristics of convenient carrying, long-term storage and low price, can be stored for two years, is suitable for occasions such as hotels, restaurants, families and the like, and is an ideal disinfectant article for daily use of outworkers and financial accounting personnel.
The beneficial effects of the invention are: the invention has the advantages of convenient and simple preparation, environmental protection, no pollution, easily obtained raw materials, less equipment investment, convenient operation, good use effect of the prepared disinfectant wet tissue, no stimulation and side effect on human bodies, obvious disinfection effect, safety and reliability.
Detailed Description
The preparation process comprises the following steps: mixing purified water and ethanol, adding CocoamidoDEA, sodium lauryl ether sulfate, TEA dodecyl sulfate, soda, sodium bicarbonate and propylene glycol, stirring to dissolve completely, adding rhizoma Atractylodis oil, ramulus Cinnamomi oil and herba Gnaphalii affinis oil, and mixing the above materials according to the following experimental examples. Mechanically stirring for 20 min at normal temperature, stopping at 200 rpm to dissolve completely to transparent and clear state, adding active carbon, stirring thoroughly to adsorb and decolorize, and filtering to obtain supernatant to obtain disinfectant (wet towel solution). And (3) soaking or spraying the disinfectant and the wood pulp paper towel according to the weight of 1.
The disinfectant adopts different components and proportions for experiments, and the details are as follows.
Comparative example 1
Ethanol: 3% of rhizoma atractylodis volatile oil: 1.0%, cocamide DEA:0.5%, sodium lauryl ether sulfate: 3%, TEA dodecyl sulfate: 2.0%, propylene glycol: 5% and purified water: and (4) the balance.
Comparative example 2
Ethanol: 5% of rhizoma atractylodis volatile oil: 1.5%, cocamide DEA:1.0%, sodium lauryl ether sulfate: 4%, TEA dodecyl sulfate: 3.0%, propylene glycol: 8% of purified water: and (4) the balance.
Comparative example 3
Ethanol: 3% of cassia twig volatile oil: 0.8%, cocamide DEA:0.5%, sodium lauryl ether sulfate: 3%, TEA dodecyl sulfate: 2.0%, propylene glycol: 5% and purified water: and the balance.
Comparative example 4
Ethanol: 5% of cassia twig volatile oil: 1.2%, cocamide DEA:1.0%, sodium lauryl ether sulfate: 4%, TEA dodecyl sulfate: 3.0%, propylene glycol: 8% and purified water: and (4) the balance.
Example 1
Ethanol: 3% and rhizoma atractylodis volatile oil: 1.0% and cassia twig volatile oil: 0.8%, cocamide DEA:0.5%, sodium lauryl ether sulfate: 3%, TEA dodecyl sulfate: 2.0%, propylene glycol: 5% and purified water: and (4) the balance.
Example 2
Ethanol: 5% and rhizoma atractylodis volatile oil: 1.5% and cassia twig volatile oil: 1.2%, cocamide DEA:1.0%, sodium lauryl ether sulfate: 4%, TEA dodecyl sulfate: 3.0%, propylene glycol: 5% and purified water: and the balance.
Example 3
Ethanol: 4% of rhizoma atractylodis volatile oil: 1.5% and cassia twig volatile oil: 0.8%, cocamide DEA:0.5%, sodium lauryl ether sulfate: 3%, TEA dodecyl sulfate: 2.0%, propylene glycol: 6% and purified water: and (4) the balance.
Example 4
Ethanol: 4%, rhizoma atractylodis volatile oil: 1.0 percent of cassia twig volatile oil: 1.2%, cocamide DEA:1.0%, sodium lauryl ether sulfate: 4%, TEA dodecyl sulfate: 3.0%, propylene glycol: 6% and purified water: and (4) the balance.
Example 5
Ethanol: 4%, rhizoma atractylodis volatile oil: 1.0% and cassia twig volatile oil: 1.0%, cocamide DEA:0.8%, sodium lauryl ether sulfate: 3.5%, TEA dodecyl sulfate: 2.4%, propylene glycol: 6% and purified water: and (4) the balance.
Example 6
Ethanol: 4%, rhizoma atractylodis volatile oil: 1.1% and cassia twig volatile oil: 0.9%, cocamide DEA:0.6%, sodium lauryl ether sulfate: 3.8%, TEA dodecyl sulfate: 2.6%, propylene glycol: 7% and purified water: and (4) the balance.
Example 7
Ethanol: 4% of rhizoma atractylodis volatile oil: 1.0 percent of cassia twig volatile oil: 1.1%, cocamide DEA:0.8%, sodium lauryl ether sulfate: 3.5%, TEA dodecyl sulfate: 2.4%, propylene glycol: 5%, soda: 0.4%, baking soda 0.2%, purified water: and the balance.
Example 8
Ethanol: 4%, rhizoma atractylodis volatile oil: 1.1% and cassia twig volatile oil: 0.8%, cocamide DEA:0.6%, sodium lauryl ether sulfate: 3.8%, TEA dodecyl sulfate: 2.6%, propylene glycol: 5%, soda: 0.5%, baking soda 0.5%, purified water: and the balance.
Example 9
Ethanol: 3% and rhizoma atractylodis volatile oil: 1.0 percent of cassia twig volatile oil: 0.8%, medicated leaven oil 0.1%, cocamide DEA:0.5%, sodium lauryl ether sulfate: 3%, TEA dodecyl sulfate: 2.0%, propylene glycol: 5% and purified water: and the balance.
Example 10
Ethanol: 5% of rhizoma atractylodis volatile oil: 1.5% and cassia twig volatile oil: 1.2%, medicated leaven oil 0.3%, cocamide DEA:1.0%, sodium lauryl ether sulfate: 4%, TEA dodecyl sulfate: 3.0%, propylene glycol: 5% and purified water: and (4) the balance.
Example 11
Ethanol: 4%, rhizoma atractylodis volatile oil: 1.5% and cassia twig volatile oil: 0.8%, medicated leaven oil 0.1%, cocamide DEA:0.5%, sodium lauryl ether sulfate: 3%, TEA dodecyl sulfate: 2.0%, propylene glycol: 6% and purified water: and (4) the balance.
Example 12
Ethanol: 4%, rhizoma atractylodis volatile oil: 1.0 percent of cassia twig volatile oil: 1.2%, herb starter oil 0.2%, cocamide DEA:1.0%, sodium lauryl ether sulfate: 4%, TEA dodecyl sulfate: 3.0%, propylene glycol: 6% and purified water: and (4) the balance.
Quantitative sterilization test of disinfectant suspension:
(1) Three strains of staphylococcus aureus, escherichia coli and candida albicans are selected to prepare experimental bacterial suspensions according to the sterilization technical specification, and the concentration of the experimental bacterial suspensions is 1 x 108 cfu/ml-5 x 108cfu/ml.
(2) Taking a large sterile test tube for a disinfection test, firstly adding 0.5ml of test bacterial suspension, then adding 0.5ml of organic interference substance, uniformly mixing, placing in a water bath at 20 +/-1 ℃ for 5min, sucking 4.0ml of disinfectant prepared in each example and comparative example by using a sterile pipette, injecting into the disinfectant, rapidly mixing uniformly and immediately timing.
(3) When the test bacteria and the disinfectant are interacted for each preset time, 0.5ml of the mixed solution of the test bacteria and the disinfectant is respectively sucked and added into 4.5ml of the sterilized neutralizer, and the mixture is uniformly mixed.
(4) Adding neutralizer into the mixed solution of the test bacteria and the disinfectant for 10min, respectively sucking 1.0ml of sample solution, measuring the number of viable bacteria by viable bacteria culture counting method, and inoculating 2 plates to each tube of sample solution. If the number of colonies growing on the plate is large, serial 10-fold dilution can be performed, and viable bacteria culture counting can be performed.
(5) Meanwhile, the diluent is used for replacing disinfectant, and a parallel test is carried out to be used as a positive control.
(6) Culturing all test samples in an incubator at 37 ℃, and culturing the bacterial propagules for 48 hours to observe the final result; the bacterial spores were cultured for 72h to observe the final results.
(7) The test was repeated 3 times, and the viable bacteria concentration (cfu/ml) of each group was calculated and converted to a log value (N), and then the killing log value was calculated according to the following formula:
log Kill (KL) = log of mean viable bacteria concentration of control group (No) -log of viable bacteria concentration of test group (Nx)
The test results are shown in table 1.
Table 1: quantitative sterilization test result of suspension
The results of the sterilization test show that: the high-concentration atractylodes oil and cassia twig oil have strong killing effect on staphylococcus aureus when being used independently, the killing log-value (KL) is more than 5.0, but the killing log-value on escherichia coli and candida albicans cannot achieve the using effect. The screening results of examples 1-8 show that the main active ingredients in the rhizoma atractylodis volatile oil and the cassia twig volatile oil produce synergistic effect after the rhizoma atractylodis volatile oil and the cassia twig volatile oil are combined, and the rhizoma atractylodis volatile oil and the cassia twig volatile oil can obviously kill staphylococcus aureus, escherichia coli and candida albicans while reducing the dosage. Examples 9-12 it can be seen that the addition of a small amount of herbal oil further enhances the bactericidal effect.
Claims (4)
1. The pure natural plant essential oil sterilization and disinfection wet tissue consists of dust-free paper and wet tissue liquid, and is characterized in that: the wet tissue liquid consists of the following raw materials in parts by weight: ethanol: 3% -5% of rhizoma atractylodis volatile oil: 1.0-1.2%, and cassia twig volatile oil: 0.8% -1.0%, cocamide DEA:0.5% -1.0%, sodium lauryl ether sulfate: 3% -4%, TEA dodecyl sulfate: 2.0% -3.0%, propylene glycol: 5% -8%, soda: 0.4% -0.5%, baking soda: 0.2-0.5%, purified water: and (4) the balance.
2. The disinfectant wipe as set forth in claim 1, wherein the rhizoma atractylodis volatile oil is prepared by steam distillation: pulverizing rhizoma Atractylodis into dry powder, placing into a steam distillation extractor containing 10 times of water, controlling the temperature at about 100 deg.C, stopping extraction when the liquid flowing down from the branch pipe of the extractor is colorless, removing lower part of distilled water with a separating funnel to obtain oily crude extract, sealing, and storing in a refrigerator at 4 deg.C for use.
3. The moist disinfectant wipe as set forth in claim 1, wherein the volatile oil of cinnamomum cassia twig is prepared by steam distillation: pulverizing ramulus Cinnamomi into dry powder, placing into a steam distillation extractor containing 12 times of water, controlling temperature at 100 deg.C, stopping extraction when the liquid flowing down from the branch pipe of the extractor is colorless, removing lower part of distilled water with separating funnel to obtain oily crude extract, sealing, and storing in 4 deg.C refrigerator.
4. The method for preparing a sterilized wet wipe as set forth in claim 1, comprising the steps of: mixing purified water and ethanol uniformly, adding Cocoamide DEA, sodium lauryl ether sulfate, TEA dodecyl sulfate, soda, sodium bicarbonate and propylene glycol respectively, stirring to dissolve completely, adding rhizoma Atractylodis oil and ramulus Cinnamomi oil, mechanically stirring to dissolve completely to transparent and clear state, adding active carbon, stirring completely to adsorb and decolorize, and filtering to obtain supernatant to obtain disinfectant; and soaking or spraying the disinfectant and the wood pulp paper towel to obtain the disinfected paper towel.
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| WO2021022562A1 (en) * | 2019-08-08 | 2021-02-11 | 中国医学科学院药用植物研究所 | Pure natural compound essential oil having broad-spectrum bactericidal activity and preparation and application thereof |
| CN112680877B (en) * | 2020-11-27 | 2021-10-01 | 浙江雅宝无纺布制品有限公司 | Antibacterial non-woven fabric and preparation process thereof |
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| CN105012161A (en) * | 2014-04-22 | 2015-11-04 | 霍锴 | Disinfectant wet tissue |
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| CN105012161A (en) * | 2014-04-22 | 2015-11-04 | 霍锴 | Disinfectant wet tissue |
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| Title |
|---|
| 王建新.苍术.《化妆品植物原料手册》.化学工业出版社,2009,第68、69、96、97页. * |
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