CN104127779B - A kind of Chinese herb compound washing lotion of anti-inflammation and preparation method thereof - Google Patents
A kind of Chinese herb compound washing lotion of anti-inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicines, and in particular to Chinese herb compound washing lotion of a kind of anti-inflammation and preparation method thereof.The technical problem to be solved in the present invention is to supply a kind of anti-inflammation Chinese herb compound washing lotion using coptis lime-ash as primary raw material.The technical scheme is that a kind of Chinese herb compound washing lotion of anti-inflammation, is made up of the raw material of following percentage by weight：Coptis lime-ash 20 30%, kuh-seng 15 20%, golden cypress 5 10%, frutus cnidii 15 20%, smilax 15 20%, Chinese prickly ash 5 10%, the tuber of stemona 5 10%, peppermint 0.2 2.0%, acetic acid chlorine chlorhexidine 1.0 3.0%, polysorbate 2 3%, surplus are benzylated acid sodium.Present invention also offers the preparation method of the Chinese herbal compound preparation.The Chinese herbal lotion of the present invention has stronger killing action to various vulvas and pruritus of vagina etc. caused by the pathogenic microbes such as staphylococcus aureus, Escherichia coli, Candida albicans.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese herb compound washing lotion of anti-inflammation and its preparation side
Method.
Background technology
After skin infection bacterium, especially various fungies etc. will produce the various reactions such as inflammation and itch.Resisted using various
Although raw element can sterilize, drug tolerant bacteria is easily produced, its antibacterial and antiphlogistic effects are undesirable after long-term use, utilized
The compound of the prepared from traditional Chinese medicines of anti-inflammation, due to being compound antimicrobial component, it is not easy to produce drug resistance；Plus Chinese herbal medicine peace
Quan Xinggao, is easily acceptable to the market.Current Chinese herbal medicine is the various skin lotions that raw material is prepared, such as " clean that is cloudy " washing lotion (cnidium monnieri
Son, folium artemisiae argyi, levisticum, grass-leaved sweetflag, rhizoma atractylodis, peppermint, golden cypress, radix scutellariae, kuh-seng, the fruit of summer cypress, oriental wormwood, Golden Larch Bark, cape jasmine, Honeysuckle flower；
Solubilizer, sodium benzoate, essence) and " new Fukang cleaning solution " it is (coptis, kuh-seng, golden cypress, frutus cnidii, smilax, Chinese prickly ash, the tuber of stemona, thin
Lotus, acetic acid chlorine chlorhexidine, polysorbate, benzylated acid sodium) etc., for eczema (damp-heat type), contact dermatitis, (heat toxin folder is wet
Type), tinea pedis and manus (rheumatism heat type) etc., be received by the market, annual sales volume is very big.
The research of Chinese medical herb antibacterial lotion is enriched very much.Deng Lianfen etc. reports a kind of (the sterilization effect of Chinese Medicine Antibacterial Lotion
Fruit and its Experimental Observation On Toxicity, Deng Lianfen etc., Chinese Disinfection magazine, 2008,25 (3)：268) with bamboo extract, needle juniper
The Chinese medical extracts such as acid, quercitrin, the alcohol of side one hundred are that main component is formulated product, and its antibacterial effect is preferable.Patented technology
(CN201310267817) disclose a kind of Chinese medical herb antibacterial lotion, including Chinese mugwort leaf, kuh-seng, the tuber of stemona, frutus cnidii, the fruit of summer cypress,
Menthol, borneol, lactic acid, RH-40, DTC, CAB-35, glycerine, ethanol, acetic acid chlorhexidine etc., the product can kill cause of disease rapidly
Bacterium, and inflammation-resisting itch-stopping function well；Patented technology (CN200910247163) disclose it is a kind of have it is good sterilize, antipruritic work(
The Chinese Medicine Antibacterial Lotion and its preparation technology of effect, the Chinese medicinal lotion is by Asian puccoon, frutus cnidii, Asiatic plantain, the tuber of stemona, Chinese prickly ash, acetic acid chlorine
Oneself is fixed, borneol composition, and main kill causes the cause of diseases such as staphylococcus aureus, Candida albicans, the Escherichia coli of gynaecological imflammation
Body；Patented technology (CN200810107417) disclose it is a kind of have good sterilization, the Chinese Medicine Antibacterial Lotion of itching-relieving efficacies and
Its preparation technology, the Chinese medicinal lotion is made up of kuh-seng, frutus cnidii, Asiatic plantain, the tuber of stemona, Chinese prickly ash, chlorhexidine acetate, borneol, mainly
Killing causes the pathogen such as staphylococcus aureus, Candida albicans, the Escherichia coli of gynaecological imflammation；Patented technology
(CN200810073953) disclose a kind of with good sterilization, the Chinese Medicine Antibacterial Lotion of itching-relieving efficacies and its preparation technology,
The Chinese medicinal lotion is made up of kuh-seng, frutus cnidii, the capsule of weeping forsythia, Chinese prickly ash, chlorhexidine acetate, and main kill causes the golden yellow of gynaecological imflammation
The pathogen such as staphylococcus, Candida albicans, Escherichia coli；Patented technology (CN200810073954) discloses a kind of with good
Good sterilization, the Chinese Medicine Antibacterial Lotion of itching-relieving efficacies and its preparation technology, the Chinese medicinal lotion is by kuh-seng, frutus cnidii, the capsule of weeping forsythia, flower
Green pepper, chlorhexidine acetate, borneol composition, it is main to kill the staphylococcus aureus for causing gynaecological imflammation, Candida albicans, large intestine bar
The pathogen such as bacterium；Patented technology (CN200810073954) discloses a kind of Chinese medicine with good sterilization, itching-relieving efficacies and resisted
Bacterium washing lotion and its preparation technology, the Chinese medicinal lotion are made up of kuh-seng, frutus cnidii, the capsule of weeping forsythia, Chinese prickly ash, chlorhexidine acetate, borneol, mainly
Killing causes the pathogen such as staphylococcus aureus, Candida albicans, the Escherichia coli of gynaecological imflammation；Patented technology
(CN200810093419) disclose a kind of Chinese medical herb antibacterial lotion, effective ingredient be snake gall, amino-acid salt, frutus cnidii, kuh-seng,
The Chinese bulbul, first cypress, menthol, with antibacterial effect is notable, nontoxic, non-stimulated, non-corrosiveness, toxicity, chemical property are not produced
Stable the features such as；Patented technology (CN200510134481) discloses a kind of new treatment tinea of feet and hands, pin sweat, foot odour, brothers' chap
Split, pharmaceutical composition of the hand-foot skin disease such as onychomycosis and preparation method thereof, the pharmaceutical composition contains following parts by weight
Bulk drug：20-35 parts of the capsule of weeping forsythia, 20-30 parts of Orostachys fimbriatus, windproof 12-25 parts, 8-20 parts of kuh-seng, 6-20 parts of climbing groundsel, Chinese violet
6-18 parts, 5-15 parts of cortex acanthopanacis, medicine of the present invention is for tinea of feet and hands, pin sweat, foot odour, rhagadia manus et pedis, brothers' skin such as onychomycosis
Skin disease has significant curative effect；Patented technology (CN200510134481) discloses a kind of new treatment tinea of feet and hands, pin sweat, pin
Pharmaceutical composition of the hand-foot skin disease such as smelly, rhagadia manus et pedis, onychomycosis and preparation method thereof, the pharmaceutical composition contains following
The bulk drug of parts by weight：20-35 parts of the capsule of weeping forsythia, 20-30 parts of Orostachys fimbriatus, windproof 12-25 parts, 8-20 parts of kuh-seng, 6-20 parts of climbing groundsel,
6-18 parts of fourth, 5-15 parts of cortex acanthopanacis, medicine of the present invention is for tinea of feet and hands, pin sweat, foot odour, rhagadia manus et pedis, brothers' skin such as onychomycosis
Skin disease has significant curative effect.But, to current position, there is not yet researching and developing the report of anti-bacterial lotion using coptis lime-ash.
At present, the washing lotion that anti-inflammation works well such as " new Fukang cleaning solution ", it is mostly clearing heat and detoxicating, anti-using the coptis etc.
The good Chinese medicine of bacterium anti-inflammatory effects.Not only anti-inflammation effect is good for the coptis, and security is very high, and " coptis is best antibacterial
Medicine " (on March 24th, 2010, traditional Chinese medical science channel _ phoenix net).But, coptis value is expensive (current market price is 100 yuan/Kg), grinds
The product of hair does not have too strong competitiveness in cost.
The coptis is cold in nature, bitter, with heat-clearing and damp-drying drug, the function of purging intense heat and detonicating, is the traditional Chinese medicine of China.Coptis lime-ash is
After the coptis " hair lump " (coptis fresh goods with fibrous radix of coptis, petiole, skin and silt etc.) drying, " playing groove cage " (removes fibrous radix of coptis, leaf
Handle, epidermis and silt etc.) during, the discarded object removed.Research finds that fibrous radix of coptis and cauline leaf contain substantial amounts of alkaloid and lived
Property composition (Pang Jie etc., fibrous radix of coptis alkaloid spatial and temporal distributions and Habitat producing technical study, Chinese medicine, 37 (3)：397,2014),
With good antibacterial and anti-inflammation functions, the main component of two coptis lime-ash is exactly fibrous radix of coptis and coptis cauline leaf.Up to the present, it is yellow
Even there is not been reported for the exploitation of lime-ash, and the technology and product of anti-inflammation skin lotion are developed especially with coptis lime-ash
Have no report.
The content of the invention
The technical problem to be solved in the present invention is to provide one kind using coptis lime-ash as primary raw material, it is aided with other traditional Chinese medicine ingredients
The Chinese herb compound washing lotion of the anti-inflammation of composition.
The technical scheme is that a kind of Chinese herb compound washing lotion of anti-inflammation, by the raw material of following percentage by weight
It is made：Coptis lime-ash 20-30%, kuh-seng 15-20%, golden cypress 5-10%, frutus cnidii 15-20%, smilax 15-20%, Chinese prickly ash
5-10%, tuber of stemona 5-10%, peppermint 0.2-2.0%, acetic acid chlorine chlorhexidine 1.0-3.0%, polysorbate 2-3%, surplus are benzene
Methyl acid sodium.
Most preferably, the Chinese herb compound washing lotion is made up of the Chinese herbal medicine of following weight percentage：Coptis lime-ash 25%,
Kuh-seng 17%, golden cypress 8%, frutus cnidii 14%, smilax 14%, Chinese prickly ash 8%, the tuber of stemona 8%, peppermint 0.8%, acetic acid chlorine chlorhexidine
2%th, polysorbate 3%, surplus are benzylated acid sodium.
Present invention also offers the preparation method of the Chinese herb compound washing lotion, comprise the following steps：
A, raw material prepare：According to the preparation raw material of following percentage by weight：Coptis lime-ash 20-30%, kuh-seng 15-20%,
Golden cypress 5-10%, frutus cnidii 15-20%, smilax 15-20%, Chinese prickly ash 5-10%, tuber of stemona 5-10%, peppermint 0.2-2.0%, vinegar
Sour chlorine chlorhexidine 1.0-3.0%, polysorbate 2-3%, surplus are benzylated acid sodium；
B, decoction：Coptis lime-ash, kuh-seng, golden cypress, frutus cnidii, smilax, Chinese prickly ash, the tuber of stemona are added water to cook 2~3 times, the
One time 1~2 hour, hereafter 0.5~1 hour/time, often decocted and is once filtered, and merging filtrate is concentrated under reduced pressure into phase at 50 DEG C
Make alcohol content up to 60~70%W/V the clear cream that density is 1.20~1.25, plus ethanol, stand 12~24 hours, filter, reclaim
Ethanol, adds polysorbate and stirs, and merges with above-mentioned filtrate；
C, mixing：Take acetic acid chlorhexidine, sodium benzoate, peppermint, dissolved respectively with ethanol, filter, be added sequentially to step b
In obtained mixed liquor, concentration is added water to for 0.1g active compounds/mL, stirs, produces.
Present invention also offers the application method of the Chinese herb compound washing lotion, comprise the following steps：Take the Chinese herbal medicine
30~50ml of Compound Prescription Lotion, plus 6~8 times of amount warm waters dilutions, hip bath or flushing, keeps decoction affected part 5 minutes；Or cotton of getting it filled
Dip in after the Chinese herb compound washing lotion, be directly applied to affected part.
The Chinese herb compound washing lotion of the present invention is to diseases such as staphylococcus aureus, Escherichia coli, Candida albicans (mould)
Various vulva and vagina exceptions, itch, stench, white (or yellow) secreting liquid etc. have stronger caused by pathogenic micro-organism
Killing action.
Coptis lime-ash is mainly made up of fibrous radix of coptis, coptis petiole and/or coptis epidermis etc..Result of study is shown：Fibrous radix of coptis
Containing 2~4% total alkaloid, stem contains 1~3% total alkaloid.Coptis lime-ash contain with active component as Rhizoma Coptidis,
With with pharmacological function as Rhizoma Coptidis.There is the Chinese herbal medicine of very strong " antibacterial " and " anti-inflammatory " functional development using coptis lime-ash
Compound Prescription Lotion, can not only be sterilized and anti-inflammatory, and cost is extremely low (1/10th of the cost of coptis lime-ash less than the coptis), peace
Full property is fine.
In compound of the present invention, coptis lime-ash is cold in nature, bitter, is our with heat-clearing, eliminating dampness, purging intense heat, the function of detoxifying
Monarch drug in a prescription, plays " antibacterial " and " anti-inflammatory "；It is kuh-seng bitter, cold in nature, there is heat-clearing and damp-drying drug, desinsection (external application), be this
The ministerial drug of side, plays " antibacterial " and " desinsection " in we, while playing synergy with coptis lime-ash；Golden cypress bitter, property
It is cold, there is eliminating dampness, purging intense heat, removing toxic substances, be the ministerial drug of we, play " antibacterial " and " anti-inflammatory " in we, simultaneously
Synergy is played with coptis lime-ash；It is frutus cnidii bitter, warm-natured, there is eliminating dampness, wind-dispelling, desinsection, be the ministerial drug of we,
Play " antibacterial " and " antipruritic " in we, while playing synergy with coptis lime-ash；Smilax is sweet, mild-natured, with dispelling
Damp and hot, removing toxic substances cool blood effect, is the ministerial drug of we, plays " antibacterial " and " desinsection " in we, while grey with the coptis
Slag plays synergy；Chinese prickly ash is warm-natured, pungent, there is warming spleen and stomach for dispelling cold, stomach invigorating dehumidifying, analgesic desinsection, removing toxic substances qi-regulating, the work(of antipruritic raw meat of dispelling
Effect, is the ministerial drug of we, plays " desinsection " and " antipruritic " in we, while playing synergy with coptis lime-ash；The tuber of stemona
It is sweet, warm-natured, there is desinsection and delousion, be the ministerial drug of we, play " desinsection " in we, while grey with the coptis
Slag plays synergy；Peppermint is pungent, cool in nature, has effects that radiating, removing toxic substances, is the ministerial drug of we, is risen in we " radiating "
Effect, while playing synergy with coptis lime-ash.A few herbs are shared, and can strengthen drug effect.
In the present invention, acetic acid chlorine chlorhexidine has antibacterial action, and polysorbate plays emulsifying agent, and benzylated acid sodium rises
Solubilising and antisepsis；It is collectively forming the active ingredient of this product.
Beneficial effects of the present invention：The present invention makes full use of the heat-clearing of coptis lime-ash dry using coptis lime-ash as primary raw material
The functions such as wet, purging intense heat and detonicating, antibacterial, antiviral and anti-inflammatory, are aided with other Chinese medicines and auxiliary material, exploitation with antibacterial, it is antiviral, disappear
The skin lotion of the effects such as scorching, antipruritic, radiating.The primary raw material coptis lime-ash of this product is twice laid, low with cost
Advantage, while improving the utilization rate of resource, has broad application prospects.
Embodiment
The preparation of the Chinese herb compound washing lotion of the present invention of embodiment 1
25 kilograms of coptis lime-ash, 17 kilograms of kuh-seng, golden cypress 8,14 kilograms of frutus cnidii, 14 kilograms of smilax, 8 kilograms of Chinese prickly ash,
8 kilograms of the tuber of stemona, 0.8 kilogram of peppermint, 2 kilograms of acetic acid chlorine chlorhexidine, 3 kilograms of polysorbate, 0.2 kilogram of benzylated acid sodium.More than
Seven flavor medicine material, is added water to cook secondary, 2 hours first times, second 1 hour, filtration, merging filtrate is concentrated under reduced pressure into relatively close
Spend makes alcohol content up to 60%~70% for the clear cream of 1.20~1.25 (50 DEG C), plus ethanol, stands 24 hours, and second is reclaimed in filtration
Alcohol, adds polysorbate and stirs, and merges with above-mentioned filtrate.It is another to take acetic acid chlorhexidine, sodium benzoate, peppermint, use respectively
Ethanol dissolving filtration, sequentially adds in above-mentioned mixed liquor, adds water to ormal weight, stir, produce.In use, taking this product 30
~50ml, plus 6~8 times of amount warm water dilutions, hip bath or flushing, keeps decoction at 5 minutes, or take the absorbent cotton of this product decoction straight
Connect and be applied to affected part.
The preparation of the Chinese herb compound washing lotion of the present invention of embodiment 2
20 kilograms of coptis lime-ash, 15 kilograms of kuh-seng, golden cypress 5,20 kilograms of frutus cnidii, 20 kilograms of smilax, 7 kilograms of Chinese prickly ash,
7 kilograms of the tuber of stemona, 1 kilogram of peppermint, 2 kilograms of acetic acid chlorine chlorhexidine, 2.9 kilograms of polysorbate, 0.1 kilogram of benzylated acid sodium.More than
Seven flavor medicine material, is added water to cook three times, 1 hour for the first time, second 0.5 hour, third time 0.5 hour, filtration, merging filtrate,
The clear cream that relative density is 1.20~1.25 (50 DEG C) is concentrated under reduced pressure into, plus ethanol makes alcohol content up to 60%~70%, stands 12
Hour, filtration reclaims ethanol, adds polysorbate and stir, merge with above-mentioned filtrate.Separately take acetic acid chlorhexidine, benzene first
Sour sodium, peppermint, respectively with ethanol dissolve filter, sequentially add in above-mentioned mixed liquor, add water to ormal weight, stir, produce.
In use, taking 30~50ml of this product, plus 6~8 times of amount warm water dilutions, hip bath or flushing, keep decoction at 5 minutes, or taken
The absorbent cotton of this product decoction is directly applied to affected part.
The preparation of the Chinese herb compound washing lotion of the present invention of embodiment 3
30 kilograms of coptis lime-ash, 20 kilograms of kuh-seng, golden cypress 5,15 kilograms of frutus cnidii, 15 kilograms of smilax, 5 kilograms of Chinese prickly ash,
5 kilograms of the tuber of stemona, 2 kilograms of peppermint, 1 kilogram of acetic acid chlorine chlorhexidine, 1 kilogram of polysorbate, 1 kilogram of benzylated acid sodium.The taste of the above seven
Medicinal material, is added water to cook three times, 1 hour for the first time, second 1 hour, and third time 0.5 hour, filtration, merging filtrate is depressurized dense
The clear cream that relative density is 1.20~1.25 (50 DEG C) is reduced to, plus ethanol makes alcohol content up to 60%~70%, stands 18 hours, filter
Cross, reclaim ethanol, add polysorbate and stir, merge with above-mentioned filtrate.It is another take acetic acid chlorhexidine, it is sodium benzoate, thin
Lotus, respectively with ethanol dissolve filter, sequentially add in above-mentioned mixed liquor, add water to ormal weight, stir, produce.In use,
30~50ml of this product is taken, plus 6~8 times of amount warm water dilutions, hip bath or flushing, keeps decoction at 5 minutes, or taken this product decoction
Absorbent cotton be directly applied to affected part.
The preparation of the Chinese herb compound washing lotion of the present invention of embodiment 4
25 kilograms of coptis lime-ash, 18 kilograms of kuh-seng, golden cypress 7,13 kilograms of frutus cnidii, 17 kilograms of smilax, 10 kilograms of Chinese prickly ash,
5 kilograms of the tuber of stemona, 0.2 kilogram of peppermint, 2 kilograms of acetic acid chlorine chlorhexidine, 2 kilograms of polysorbate, 0.7 kilogram of benzylated acid sodium.More than
Seven flavor medicine material, is added water to cook secondary, 2 hours first times, second 1 hour, filtration, merging filtrate is concentrated under reduced pressure into relatively close
Spend makes alcohol content up to 60%~70% for the clear cream of 1.20~1.25 (50 DEG C), plus ethanol, stands 24 hours, and second is reclaimed in filtration
Alcohol, adds polysorbate and stirs, and merges with above-mentioned filtrate.It is another to take acetic acid chlorhexidine, sodium benzoate, peppermint, use respectively
Ethanol dissolving filtration, sequentially adds in above-mentioned mixed liquor, adds water to ormal weight, stir, produce.In use, taking this product 30
~50ml, plus 6~8 times of amount warm water dilutions, hip bath or flushing, keeps decoction at 5 minutes, or take the absorbent cotton of this product decoction straight
Connect and be applied to affected part.
The preparation of the Chinese herb compound washing lotion of the present invention of embodiment 5
25 kilograms of coptis lime-ash, 15 kilograms of kuh-seng, golden cypress 7,13 kilograms of frutus cnidii, 17 kilograms of smilax, 7 kilograms of Chinese prickly ash,
7 kilograms of the tuber of stemona, 1 kilogram of peppermint, 2 kilograms of acetic acid chlorine chlorhexidine, 2 kilograms of polysorbate, 4 kilograms of benzylated acid sodium.The taste of the above seven
Medicinal material, is added water to cook secondary, 2 hours first times, second 1 hour, filtration, merging filtrate, being concentrated under reduced pressure into relative density is
The clear cream of 1.20~1.25 (50 DEG C), plus ethanol make alcohol content up to 60%~70%, stand 24 hours, filtration, reclaim ethanol, then
Add polysorbate to stir, merge with above-mentioned filtrate.It is another take acetic acid chlorhexidine, it is sodium benzoate, peppermint, molten with ethanol respectively
Solution filtration, sequentially adds in above-mentioned mixed liquor, adds water to ormal weight, stir, produce.In use, 30~50ml of this product is taken,
Plus 6~8 times of amount warm water dilutions, hip bath or flushing, keep decoction at 5 minutes, or take the absorbent cotton of this product decoction to be directly applied to
Affected part.
The effect test of the Chinese herb compound washing lotion of the present invention of embodiment 6
The preparation of medicine 1：25 kilograms of coptis lime-ash, 17 kilograms of kuh-seng, 8 kilograms of golden cypress, 14 kilograms of frutus cnidii, smilax 14
Kilogram, 8 kilograms of Chinese prickly ash, 8 kilograms of the tuber of stemona, 0.8 kilogram of peppermint, 2 kilograms of acetic acid chlorine chlorhexidine, 3 kilograms of polysorbate, benzylated acid
0.2 kilogram of sodium.Above seven flavor medicine material, is added water to cook secondary, 2 hours first times, second 1 hour, filtration, merging filtrate subtracts
Pressure is concentrated into the clear cream that relative density is 1.20~1.25 (50 DEG C), plus ethanol makes alcohol content up to 60%~70%, stands 24 small
When, filtration reclaims ethanol, adds polysorbate and stir, merge with above-mentioned filtrate.Separately take acetic acid chlorhexidine, benzoic acid
Sodium, peppermint, respectively with ethanol dissolve filter, sequentially add in above-mentioned mixed liquor, add water to ormal weight, stir, it is standby.
The preparation of medicine 2：20 kilograms of coptis lime-ash, 15 kilograms of kuh-seng, golden cypress 5,20 kilograms of frutus cnidii, smilax 20 are public
Jin, 7 kilograms of Chinese prickly ash, 7 kilograms of the tuber of stemona, 1 kilogram of peppermint, 2 kilograms of acetic acid chlorine chlorhexidine, 2.9 kilograms of polysorbate, benzylated acid sodium
0.1 kilogram.Above seven flavor medicine material, adds water to cook secondary, 2 hours for the first time, second 1 hour, filtration, merging filtrate, decompression
The clear cream that relative density is 1.20~1.25 (50 DEG C) is concentrated into, plus ethanol makes alcohol content up to 60%~70%, stands 24 hours,
Filtration, reclaims ethanol, adds polysorbate and stir, merge with above-mentioned filtrate.It is another take acetic acid chlorhexidine, sodium benzoate,
Peppermint, respectively with ethanol dissolve filter, sequentially add in above-mentioned mixed liquor, add water to ormal weight, stir, it is standby.
The preparation of control drug 1：97 kilograms of coptis lime-ash, 2.5 kilograms of polysorbate, 0.5 kilogram of benzylated acid sodium.The coptis
Lime-ash is added water to cook secondary, 2 hours first times, second 1 hour, filtration, merging filtrate, and being concentrated under reduced pressure into relative density is
The clear cream of 1.20~1.25 (50 DEG C), plus ethanol make alcohol content up to 60%~70%, stand 24 hours, filtration, reclaim ethanol, then
Add polysorbate and this sodium formate stirs, it is standby.
The preparation of control drug 2：77 kilograms of coptis lime-ash, 20 kilograms of kuh-seng, 2.5 kilograms of polysorbate, benzylated acid sodium
0.5 kilogram.Chinese medicine, is added water to cook secondary, 2 hours first times, second 1 hour, filtration, merging filtrate is concentrated under reduced pressure into
Relative density is the clear cream of 1.20~1.25 (50 DEG C), plus ethanol makes alcohol content up to 60%~70%, stands 24 hours, filtration,
Ethanol is reclaimed, polysorbate is added and this sodium formate stirs, it is standby.
The preparation of control drug 3：67 kilograms of coptis lime-ash, 20 kilograms of kuh-seng, 10 kilograms of golden cypress, 2.5 kilograms of polysorbate,
0.5 kilogram of benzylated acid sodium.Chinese medicine, is added water to cook secondary, 2 hours first times, second 1 hour, filtration, merging filtrate,
The clear cream that relative density is 1.20~1.25 (50 DEG C) is concentrated under reduced pressure into, plus ethanol makes alcohol content up to 60%~70%, stands 24
Hour, ethanol is reclaimed in filtration, adds polysorbate and this sodium formate stirs, standby.
The preparation of control drug 4：It is 52 kilograms of coptis lime-ash, 20 kilograms of kuh-seng, 10 kilograms of golden cypress, 15 kilograms of frutus cnidii, poly-
2.5 kilograms of sorb ester, 0.5 kilogram of benzylated acid sodium.Chinese medicine, is added water to cook secondary, 2 hours first times, second 1 hour,
Filtration, merging filtrate is concentrated under reduced pressure into the clear cream that relative density is 1.20~1.25 (50 DEG C), plus ethanol makes alcohol content up to 60%
~70%, 24 hours are stood, ethanol is reclaimed in filtration, add polysorbate and this sodium formate stirs, it is standby.
The preparation of control drug 5：42 kilograms of coptis lime-ash, 15 kilograms of kuh-seng, 10 kilograms of golden cypress, 15 kilograms of frutus cnidii, soil
15 kilograms of Poria cocos, 2.5 kilograms of polysorbate, 0.5 kilogram of benzylated acid sodium.Chinese medicine, adds water to cook secondary, 2 hours first times,
Second 1 hour, filtration, merging filtrate was concentrated under reduced pressure into the clear cream that relative density is 1.20~1.25 (50 DEG C), plus ethanol makes
Alcohol content stands 24 hours up to 60%~70%, and ethanol is reclaimed in filtration, adds polysorbate and this sodium formate stirs,
It is standby.
The preparation of control drug 6：37 kilograms of coptis lime-ash, 15 kilograms of kuh-seng, 10 kilograms of golden cypress, 15 kilograms of frutus cnidii, soil
15 kilograms of Poria cocos, 5 kilograms of Chinese prickly ash, 2.5 kilograms of polysorbate, 0.5 kilogram of benzylated acid sodium.Chinese medicine, add water to cook it is secondary,
One time 2 hours, second 1 hour, filtration, merging filtrate, it is the clear of 1.20~1.25 (50 DEG C) to be concentrated under reduced pressure into relative density
Cream, plus ethanol make alcohol content up to 60%~70%, stand 24 hours, and filtration reclaims ethanol, adds polysorbate and this formic acid
Sodium stirs, standby.
The preparation of control drug 7：32 kilograms of coptis lime-ash, 15 kilograms of kuh-seng, 10 kilograms of golden cypress, 15 kilograms of frutus cnidii, soil
15 kilograms of Poria cocos, 5 kilograms of Chinese prickly ash, 5 kilograms of the tuber of stemona, 2.5 kilograms of polysorbate, 0.5 kilogram of benzylated acid sodium.Chinese medicine, adds water
Decoct secondary, 2 hours first times, second 1 hour, filtration, merging filtrate, it is 1.20~1.25 to be concentrated under reduced pressure into relative density
The clear cream of (50 DEG C), plus ethanol make alcohol content up to 60%~70%, stand 24 hours, and filtration reclaims ethanol, adds poly- sorb
Ester and this sodium formate stir, standby.
The preparation of control drug 8：31 kilograms of coptis lime-ash, 15 kilograms of kuh-seng, 10 kilograms of golden cypress, 15 kilograms of frutus cnidii, soil
15 kilograms of Poria cocos, 5 kilograms of Chinese prickly ash, 5 kilograms of the tuber of stemona, 1 kilogram of peppermint, 2.5 kilograms of polysorbate, 0.5 kilogram of benzylated acid sodium.In
Medicinal material, is added water to cook secondary, 2 hours first times, second 1 hour, filtration, merging filtrate, being concentrated under reduced pressure into relative density is
The clear cream of 1.20~1.25 (50 DEG C), plus ethanol make alcohol content up to 60%~70%, stand 24 hours, filtration, reclaim ethanol, then
Add polysorbate and this sodium formate stirs, it is standby.
Antibacterial experiment:It is test organisms from staphylococcus aureus (S.aureus) and Candida albicans (C.albicans)
Kind, using paper disk method：Corresponding strain flat board is prepared with the solid medium of preparation, insulating box culture 24h examines dirty without miscellaneous bacteria
It is standby after dye.Aseptically bacterium solution 1mL is drawn with the liquid-transfering gun and pipette tips after sterilizing and be placed in corresponding flat board, after sterilizing
Bacterium solution is uniformly applied to dissipate and is inoculated with solid agar flat board by coated with glass ring, is then affixed on the drug paper disk prepared flat
On plate, each flat board places 3 pastille scraps of paper, and a kind of experiment of every kind of medicine to test organisms repeats two flat boards.Handle well
Flat board condition of culture is respectively 37 DEG C/24h of bacterium (37 DEG C/48h of mycobacterium abscessus), and fungi is 25 DEG C/48h, and culture terminates
Measured afterwards with slide measure from the back side of culture dish and record inhibition zone and directly passed through, record unit is mm.By observing inhibition zone
Size tentatively judges the sensitiveness and its relative inhibition activities with comparative drug to different microorganisms.It is shown in Table 1.
Using effect (the antibacterial circle diameter of the Chinese herb compound washing lotion of the present invention of table 1：mm)
| Medicine | Staphylococcus aureus (S.aureus) | Candida albicans (C.albicans) |
| Medicine 1 | 63.9 | 62.5 |
| Medicine 2 | 62.8 | 62.1 |
| Control drug 1 | 23.7 | 22.3 |
| Control drug 2 | 31.3 | 30.4 |
| Control drug 3 | 38.3 | 37.9 |
| Control drug 4 | 45.5 | 45.9 |
| Control drug 5 | 50.3 | 49.9 |
| Control drug 6 | 54.3 | 54.1 |
| Control drug 7 | 56.4 | 55.9 |
| Control drug 8 | 58.7 | 58.6 |
Test result indicates that, the antibacterial effect of the Chinese herb compound washing lotion of anti-inflammation of the present invention：Coptis lime-ash is only used, i.e.,
There is preferable antibacterial effect；With the medium-height grass flavour of a drug number increase of addition, because antibacterial synergistic action effect progressively strengthens, its antibacterial
Effect progressively strengthens (inhibition zone progressively becomes big).As can be seen here, Chinese herb compound washing lotion of the present invention has very strong antibacterial action.
Claims (2)
1. a kind of Chinese herb compound washing lotion of anti-inflammation, it is characterised in that：The Chinese herb compound washing lotion is by following weight hundred
The Chinese herbal medicine of ratio is divided to be made：Coptis lime-ash 25%, kuh-seng 17%, golden cypress 8%, frutus cnidii 14%, smilax 14%, Chinese prickly ash 8%, the tuber of stemona
8%th, peppermint 0.8%, acetic acid chlorhexidine 2%, polysorbate 3%, surplus are sodium benzoate.
2. the preparation method of Chinese herb compound washing lotion described in claim 1, it is characterised in that：Comprise the following steps：
A, raw material prepare：Prepare raw material according to following percentage by weight：Coptis lime-ash 25%, kuh-seng 17%, golden cypress 8%, frutus cnidii
14%th, smilax 14%, Chinese prickly ash 8%, the tuber of stemona 8%, peppermint 0.8%, acetic acid chlorhexidine 2%, polysorbate 3%, surplus are sodium benzoate；
B, decoction：Coptis lime-ash, kuh-seng, golden cypress, frutus cnidii, smilax, Chinese prickly ash, the tuber of stemona are added water to cook 2~3 times, for the first time
1~2 hour, 0.5~1 hour/time, often decocted and is once filtered afterwards, merging filtrate, was concentrated under reduced pressure at 50 DEG C relative
Density is 1.20~1.25 clear cream, plus ethanol makes alcohol content up to 60~70%W/V, stands 12~24 hours, filters, reclaims
Ethanol, adds polysorbate and stirs, and merges with above-mentioned filtrate；
C, mixing：Acetic acid chlorhexidine, sodium benzoate, peppermint are taken, is dissolved respectively with ethanol, is filtered, is added sequentially to step b and obtains
Mixed liquor in, add water to concentration for 0.1g active compounds/mL, stir, produce.
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