CN111109259A - Composite sterilizing disinfectant - Google Patents
Composite sterilizing disinfectant Download PDFInfo
- Publication number
- CN111109259A CN111109259A CN201911380351.9A CN201911380351A CN111109259A CN 111109259 A CN111109259 A CN 111109259A CN 201911380351 A CN201911380351 A CN 201911380351A CN 111109259 A CN111109259 A CN 111109259A
- Authority
- CN
- China
- Prior art keywords
- disinfectant
- quaternary ammonium
- alkyl
- ammonium salt
- composite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000645 desinfectant Substances 0.000 title claims abstract description 67
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 46
- 239000002131 composite material Substances 0.000 title claims abstract description 45
- -1 dimethyl quaternary ammonium salt compound Chemical class 0.000 claims abstract description 96
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000008367 deionised water Substances 0.000 claims abstract description 37
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims abstract description 30
- 125000006177 alkyl benzyl group Chemical group 0.000 claims abstract description 30
- 235000019270 ammonium chloride Nutrition 0.000 claims abstract description 30
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 28
- 229920001661 Chitosan Polymers 0.000 claims abstract description 27
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 27
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 27
- 239000011787 zinc oxide Substances 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 238000002156 mixing Methods 0.000 claims abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 90
- 238000003756 stirring Methods 0.000 claims description 30
- 229940123208 Biguanide Drugs 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 20
- 229960003237 betaine Drugs 0.000 claims description 20
- 238000001914 filtration Methods 0.000 claims description 20
- 239000012535 impurity Substances 0.000 claims description 20
- 229920006395 saturated elastomer Polymers 0.000 claims description 20
- 125000004417 unsaturated alkyl group Chemical group 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 14
- 238000004090 dissolution Methods 0.000 claims description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 235000002639 sodium chloride Nutrition 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 10
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 9
- 229950010221 alexidine Drugs 0.000 claims description 9
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 claims description 9
- 229960003260 chlorhexidine Drugs 0.000 claims description 9
- 230000002070 germicidal effect Effects 0.000 claims description 6
- 235000019737 Animal fat Nutrition 0.000 claims description 5
- 239000003549 soybean oil Substances 0.000 claims description 5
- 235000012424 soybean oil Nutrition 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000003240 coconut oil Substances 0.000 claims description 3
- 235000019864 coconut oil Nutrition 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 15
- 239000007788 liquid Substances 0.000 abstract description 5
- 230000000638 stimulation Effects 0.000 abstract description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract description 3
- 239000003899 bactericide agent Substances 0.000 abstract description 3
- 239000000460 chlorine Substances 0.000 abstract description 3
- 229910052801 chlorine Inorganic materials 0.000 abstract description 3
- 231100000053 low toxicity Toxicity 0.000 abstract description 3
- 150000002978 peroxides Chemical class 0.000 abstract description 3
- 238000013329 compounding Methods 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 14
- 239000003814 drug Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 4
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 description 3
- 235000003097 Artemisia absinthium Nutrition 0.000 description 3
- 240000001851 Artemisia dracunculus Species 0.000 description 3
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 description 3
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 241001071917 Lithospermum Species 0.000 description 3
- 240000000233 Melia azedarach Species 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 239000001138 artemisia absinthium Substances 0.000 description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000972672 Phellodendron Species 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
- 239000004327 boric acid Substances 0.000 description 2
- 229960002152 chlorhexidine acetate Drugs 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- QBUKAFSEUHGMMX-MTJSOVHGSA-N (5z)-5-[[3-(1-hydroxyethyl)thiophen-2-yl]methylidene]-10-methoxy-2,2,4-trimethyl-1h-chromeno[3,4-f]quinolin-9-ol Chemical compound C1=CC=2NC(C)(C)C=C(C)C=2C2=C1C=1C(OC)=C(O)C=CC=1O\C2=C/C=1SC=CC=1C(C)O QBUKAFSEUHGMMX-MTJSOVHGSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000972673 Phellodendron amurense Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a composite sterilizing disinfectant, which is characterized by comprising the following raw materials in percentage by weight: 5-20 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 5-20 wt% of dialkyl dimethyl quaternary ammonium salt compound, 5-10 wt% of polyvinyl alcohol, 5-20 wt% of nonionic surfactant, 1-5 wt% of nano zinc oxide, 1-5 wt% of chitosan, 0.2-0.6 wt% of essence and the balance of deionized water. The composite sterilizing disinfectant is prepared by mixing and compounding C12-16 alkyl benzyl dimethyl ammonium chloride and dialkyl dimethyl quaternary ammonium salt compound, and compared with the existing chlorine-containing disinfectant and peroxide disinfectant, the composite sterilizing disinfectant has the advantages of stable disinfectant liquid performance, low toxicity and no stimulation to human bodies, long sterilization maintaining time and is an effective broad-spectrum bactericide.
Description
Technical Field
The invention relates to the technical field of disinfectants, in particular to a composite sterilizing disinfectant.
Background
The disinfectant is used for killing pathogenic microorganisms on a transmission medium, so that the requirement of harmlessness is met, the pathogenic microorganisms are killed out of a human body, the transmission path of infectious diseases is cut off, and the purpose of controlling the infectious diseases is achieved. The disinfectant in the prior art generally adopts a 'chemical disinfectant', and chemical compounds are adopted to kill microorganisms to meet the sterilization requirement. The chemical disinfectant has the advantages of stimulation to human body, bad smell, strong corrosivity and easy danger. Ultraviolet sterilization is also used, which requires unmanned operation. And the ultraviolet sterilization effect is strong, but the penetration capability to the object is weak. It is suitable for sterilizing heat-labile articles and table surface, and its UV sterilization effect is very poor.
Along with the improvement of living standard, the requirements of people on living quality are higher and higher, especially the textiles closely related to life, especially the formation of concepts of safety, comfort, health, cleanness and the like, so that the finishing processing of the textiles such as antibiosis, mildew resistance, deodorization and the like are more emphasized by people
For example, chinese patent CN105010425A discloses a disinfectant for public places, which comprises the following raw materials by weight percent: 0.5-5% of chlorhexidine acetate, 10-15% of ethanol and 3-5% of traditional Chinese medicine extract. In a specific embodiment of the invention, the public place disinfectant also comprises 0.5-3% of hydrogen peroxide. In one embodiment of the invention, the public place disinfectant also comprises boric acid 0.5-1%. In another embodiment of the present invention, the Chinese herbal medicines are lithospermum, fructus cnidii, melia azedarach, phellodendron bark and oriental wormwood. Preferably, the weight ratio of the traditional Chinese medicine raw materials is as follows: 10 parts of lithospermum, 3 parts of fructus cnidii, 3 parts of chinaberry flower, 5 parts of phellodendron and 3 parts of oriental wormwood. In a preferred embodiment of the invention, the public place disinfectant comprises the following raw materials in percentage by weight: 0.5-5% of chlorhexidine acetate, 0.5-3% of hydrogen peroxide, 0.5-1% of boric acid, 10-15% of ethanol and 3-5% of traditional Chinese medicine extract, wherein the traditional Chinese medicine is lithospermum, fructus cnidii, chinaberry flower, phellodendron and oriental wormwood. The technical scheme adopts the traditional Chinese medicine spraying environment to play a role in sterilization, and has the defects that the dispersivity of the liquid medicine in the air is not strong, the liquid medicine is easy to pollute articles, and yellow spots and corrosion appear on the articles.
Disclosure of Invention
Aiming at the defects, the invention aims to provide the composite sterilization disinfectant which can be used for sterilizing instruments, has long sterilization time and has good killing effect on fungi and bacteria.
The technical scheme of the invention is summarized as follows: the composite sterilizing disinfectant is characterized by comprising the following raw materials in percentage by weight: 5-20 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 5-20 wt% of dialkyl dimethyl quaternary ammonium salt compound, 5-10 wt% of polyvinyl alcohol, 5-20 wt% of nonionic surfactant, 1-5 wt% of nano zinc oxide, 1-5 wt% of chitosan, 0.2-0.6 wt% of essence and the balance of deionized water.
In some embodiments, the composition comprises the following raw materials in percentage by weight: 10-15 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 10-15 wt% of dialkyl dimethyl quaternary ammonium salt compound, 6-8 wt% of polyvinyl alcohol, 10-15 wt% of nonionic surfactant, 2-3 wt% of nano zinc oxide, 2-3 wt% of chitosan, 0.3-0.5 wt% of essence and the balance of deionized water.
In some embodiments, the composition comprises the following raw materials in percentage by weight: 12 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 12 wt% of dialkyl dimethyl quaternary ammonium salt compound, 7 wt% of polyvinyl alcohol, 12 wt% of nonionic surfactant, 3 wt% of nano zinc oxide, 3 wt% of chitosan, 0.4 wt% of essence and the balance of deionized water.
In some embodiments, the alkyl group in the dialkyl dimethyl quaternary ammonium salt compound is derived from a saturated or unsaturated alkyl group having from C6 to C18.
In some embodiments, the saturated or unsaturated alkyl group having 6-18 is one or a mixture of any two of animal fatty alkyl group, coconut alkyl group, or soybean oil alkyl group.
In some embodiments, the nonionic surfactant is dodecyl dihydroxyethyl betaine.
In some embodiments, the composite bactericidal disinfectant further comprises a biguanide compound, and the ratio of the biguanide compound to the dialkyl dimethyl quaternary ammonium salt compound is 1: 1-2.
In some embodiments, the biguanide compound is chlorhexidine or alexidine.
Another object of the present invention is to provide a method for preparing the composite germicidal disinfectant as claimed in claim 1, which is characterized by comprising the following steps:
the method comprises the following steps: respectively putting C12-16 alkyl benzyl dimethyl ammonium chloride, dialkyl dimethyl quaternary ammonium salt compound and polyvinyl alcohol into deionized water, stirring for 30-60 minutes, adding dodecyl dihydroxy ethyl betaine after dissolution, continuously dissolving, adjusting the pH value of the solution to 5.5-6.5 by using citric acid, and filtering to remove impurities;
step two: respectively adding nano zinc oxide and chitosan into deionized water, stirring and dissolving, adjusting the pH value of the solution to 5.5-6.7 by using citric acid, and filtering to remove impurities;
step three: and (3) fully mixing the mixture in the step one and the mixture in the step two, adjusting the pH to 5.5-6.7 by using citric acid, then adding essence, and adding a small amount of table salt to adjust the viscosity of the solution to 1.5-2(pa.s.25 ℃).
In some embodiments, in step two, the time for dissolution with stirring is 1-1.5 h.
The invention has the beneficial effects that: the composite sterilizing disinfectant is prepared by mixing and compounding C12-16 alkyl benzyl dimethyl ammonium chloride and dialkyl dimethyl quaternary ammonium salt compound, and compared with the existing chlorine-containing disinfectant and peroxide disinfectant, the composite sterilizing disinfectant has the advantages of stable disinfectant liquid performance, low toxicity and no stimulation to human bodies, long sterilization maintaining time and is an effective broad-spectrum bactericide.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
The scheme provides a composite sterilizing disinfectant, which has the innovation points that the composite sterilizing disinfectant comprises the following raw materials in percentage by weight: 5-20 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 5-20 wt% of dialkyl dimethyl quaternary ammonium salt compound, 5-10 wt% of polyvinyl alcohol, 5-20 wt% of nonionic surfactant, 1-5 wt% of nano zinc oxide, 1-5 wt% of chitosan, 0.2-0.6 wt% of essence and the balance of deionized water. As a further preference, in this embodiment of the present invention, the following raw materials are included in percentage by weight: 10-15 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 10-15 wt% of dialkyl dimethyl quaternary ammonium salt compound, 6-8 wt% of polyvinyl alcohol, 10-15 wt% of nonionic surfactant, 2-3 wt% of nano zinc oxide, 2-3 wt% of chitosan, 0.3-0.5 wt% of essence and the balance of deionized water. As a further preference, in this embodiment of the present invention, the following raw materials are included in percentage by weight: 12 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 12 wt% of dialkyl dimethyl quaternary ammonium salt compound, 7 wt% of polyvinyl alcohol, 12 wt% of nonionic surfactant, 3 wt% of nano zinc oxide, 3 wt% of chitosan, 0.4 wt% of essence and the balance of deionized water. In the invention, the C12-16 alkyl benzyl dimethyl ammonium chloride and the dialkyl dimethyl quaternary ammonium salt compound are mixed and compounded, compared with the existing chlorine-containing disinfectant and peroxide disinfectant, the disinfectant has the advantages of stable liquid medicine performance, low toxicity and no stimulation to human bodies, long sterilization maintaining time and is an effective broad-spectrum bactericide.
Specifically, the alkyl in the dialkyl dimethyl quaternary ammonium salt compound is a saturated or unsaturated alkyl from C6-C18.
Specifically, the saturated or unsaturated alkyl of C6-C18 is one or a mixture of any two of animal fatty alkyl, coconut oil alkyl and soybean oil alkyl.
Specifically, the nonionic surfactant is dodecyl dihydroxyethyl betaine.
In a preferred embodiment of the invention, the composite disinfectant further comprises a biguanide compound, and the ratio of the biguanide compound to the dialkyl dimethyl quaternary ammonium salt compound is 1: 1-2.
Specifically, the biguanide compound is chlorhexidine or alexidine.
Another object of the present invention is to provide a method for preparing the composite germicidal disinfectant as claimed in claim 1, which is characterized by comprising the following steps:
the method comprises the following steps: respectively putting C12-16 alkyl benzyl dimethyl ammonium chloride, dialkyl dimethyl quaternary ammonium salt compound and polyvinyl alcohol into deionized water, stirring for 30-60 minutes, adding dodecyl dihydroxy ethyl betaine after dissolution, continuously dissolving, adjusting the pH value of the solution to 5.5-6.5 by using citric acid, and filtering to remove impurities;
step two: respectively adding nano zinc oxide and chitosan into deionized water, stirring and dissolving, adjusting the pH value of the solution to 5.5-6.7 by using citric acid, and filtering to remove impurities;
step three: and (3) fully mixing the mixture in the step one and the mixture in the step two, adjusting the pH to 5.5-6.7 by using citric acid, then adding essence, and adding a small amount of table salt to adjust the viscosity of the solution to 1.5-2(pa.s.25 ℃).
Specifically, in the second step, the stirring and dissolving time is 1-1.5 h.
The preparation method disclosed by the invention is simple in preparation process, short in preparation period and stable in performance of the prepared product.
Specific examples and comparative examples are listed below:
example 1:
a composite sterilizing disinfectant comprises the following raw materials in percentage by weight: 5 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 5 wt% of dialkyl dimethyl quaternary ammonium salt compound, 5 wt% of polyvinyl alcohol, 5 wt% of nonionic surfactant, 1 wt% of nano zinc oxide, 1 wt% of chitosan, 0.2 wt% of essence and the balance of deionized water.
The alkyl in the dialkyl dimethyl quaternary ammonium salt compound is from saturated or unsaturated alkyl of C6-C18. And saturated or unsaturated alkyl of C6-C18 is animal fat alkyl.
The nonionic surfactant is dodecyl dihydroxyethyl betaine.
The preparation method of the composite sterilizing disinfectant comprises the following steps:
the method comprises the following steps: respectively putting C12-16 alkyl benzyl dimethyl ammonium chloride, dialkyl dimethyl quaternary ammonium salt compound and polyvinyl alcohol into deionized water, stirring for 30 minutes, adding dodecyl dihydroxy ethyl betaine after dissolution, continuously dissolving, adjusting the pH value of the solution to 5.5 by using citric acid, and filtering to remove impurities;
step two: respectively adding nano zinc oxide and chitosan into deionized water, stirring and dissolving, adjusting the pH value of the solution to 5.5 by using citric acid, and filtering to remove impurities;
step three: and (3) fully mixing the mixture obtained in the first step with the mixture obtained in the second step, adjusting the pH to 5.5 by using citric acid, adding essence, and adding a small amount of table salt to adjust the viscosity of the solution to 1.5(pa.s.25 ℃).
Specifically, in the second step, the stirring and dissolving time is 1 h.
Example 2
A composite sterilizing disinfectant comprises the following raw materials in percentage by weight: 10 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 10 wt% of dialkyl dimethyl quaternary ammonium salt compound, 6 wt% of polyvinyl alcohol, 10 wt% of nonionic surfactant, 2 wt% of nano zinc oxide, 2 wt% of chitosan, 0.3 wt% of essence and the balance of deionized water.
The alkyl in the dialkyl dimethyl quaternary ammonium salt compound is from saturated or unsaturated alkyl of C6-C18. The saturated or unsaturated alkyl of C6-C18 is coconut oil alkyl.
The nonionic surfactant is dodecyl dihydroxyethyl betaine.
In this embodiment, the composite disinfectant further includes a biguanide compound, and a ratio of the biguanide compound to the dialkyl dimethyl quaternary ammonium salt compound is 1: 1.
The biguanide compound is chlorhexidine or alexidine.
The preparation method of the composite sterilizing disinfectant has the innovation points that the preparation method comprises the following steps:
the method comprises the following steps: respectively putting C12-16 alkyl benzyl dimethyl ammonium chloride, dialkyl dimethyl quaternary ammonium salt compound and polyvinyl alcohol into deionized water, stirring for 60 minutes, adding dodecyl dihydroxy ethyl betaine after dissolution, continuously dissolving, adjusting the pH value of the solution to 6.5 by using citric acid, and filtering to remove impurities;
step two: respectively adding nano zinc oxide and chitosan into deionized water, stirring and dissolving, adjusting the pH value of the solution to 6.7 by using citric acid, and filtering to remove impurities;
step three: and (3) fully mixing the mixture obtained in the first step with the mixture obtained in the second step, adjusting the pH value to 5.5-6.7 by using citric acid, adding essence, and adding a small amount of table salt to adjust the viscosity of the solution to 2(pa.s.25 ℃).
Specifically, in the second step, the stirring and dissolving time is 1.5 h.
Example 3
A composite sterilizing disinfectant comprises the following raw materials in percentage by weight: 12 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 12 wt% of dialkyl dimethyl quaternary ammonium salt compound, 7 wt% of polyvinyl alcohol, 12 wt% of nonionic surfactant, 3 wt% of nano zinc oxide, 3 wt% of chitosan, 0.4 wt% of essence and the balance of deionized water.
The alkyl in the dialkyl dimethyl quaternary ammonium salt compound is from saturated or unsaturated alkyl of C6-C18. The saturated or unsaturated alkyl of C6-C18 is soybean oil alkyl.
The nonionic surfactant is dodecyl dihydroxyethyl betaine.
The composite sterilizing disinfectant also comprises a biguanide compound, and the ratio of the biguanide compound to the dialkyl dimethyl quaternary ammonium salt compound is 1: 2.
The biguanide compound is chlorhexidine or alexidine.
The preparation method of the composite sterilizing disinfectant comprises the following steps:
the method comprises the following steps: respectively putting C12-16 alkyl benzyl dimethyl ammonium chloride, dialkyl dimethyl quaternary ammonium salt compound and polyvinyl alcohol into deionized water, stirring for 30 minutes, adding dodecyl dihydroxy ethyl betaine after dissolution, continuously dissolving, adjusting the pH value of the solution to 5.5 by using citric acid, and filtering to remove impurities;
step two: respectively adding nano zinc oxide and chitosan into deionized water, stirring and dissolving, adjusting the pH value of the solution to 5.5 by using citric acid, and filtering to remove impurities;
step three: and (3) fully mixing the mixture obtained in the first step with the mixture obtained in the second step, adjusting the pH to 5.5 by using citric acid, adding essence, and adding a small amount of table salt to adjust the viscosity of the solution to 1.5(pa.s.25 ℃).
Specifically, in the second step, the stirring and dissolving time is 1 h.
Example 4
A composite sterilizing disinfectant comprises the following raw materials in percentage by weight: 20 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 20 wt% of dialkyl dimethyl quaternary ammonium salt compound, 10 wt% of polyvinyl alcohol, 20 wt% of nonionic surfactant, 5 wt% of nano zinc oxide, 5 wt% of chitosan, 0.6 wt% of essence and the balance of deionized water.
The alkyl in the dialkyl dimethyl quaternary ammonium salt compound is from saturated or unsaturated alkyl of C6-C18. The saturated or unsaturated alkyl of C6-C18 is soybean oil alkyl.
The nonionic surfactant is dodecyl dihydroxyethyl betaine.
The composite sterilizing disinfectant also comprises a biguanide compound, and the ratio of the biguanide compound to the dialkyl dimethyl quaternary ammonium salt compound is 1: 1.
The biguanide compound is chlorhexidine or alexidine.
The preparation method of the composite sterilizing disinfectant comprises the following steps:
the method comprises the following steps: respectively putting C12-16 alkyl benzyl dimethyl ammonium chloride, dialkyl dimethyl quaternary ammonium salt compound and polyvinyl alcohol into deionized water, stirring for 45 minutes, adding dodecyl dihydroxy ethyl betaine after dissolution, continuously dissolving, adjusting the pH value of the solution to 6 by using citric acid, and filtering to remove impurities;
step two: respectively adding nano zinc oxide and chitosan into deionized water, stirring and dissolving, adjusting the pH value of the solution to 6 by using citric acid, and filtering to remove impurities;
step three: and (3) fully mixing the mixture obtained in the first step with the mixture obtained in the second step, adjusting the pH to 6 by using citric acid, adding essence, and adding a small amount of table salt to adjust the viscosity of the solution to be 1.8(pa.s.25 ℃).
Specifically, in the second step, the stirring and dissolving time is 1.2 h.
Comparative example 1
A composite sterilizing disinfectant comprises the following raw materials in percentage by weight: 12 wt% of dialkyl dimethyl quaternary ammonium salt compound, 7 wt% of polyvinyl alcohol, 12 wt% of nonionic surfactant, 3 wt% of nano zinc oxide, 3 wt% of chitosan, 0.4 wt% of essence and the balance of deionized water.
The alkyl in the dialkyl dimethyl quaternary ammonium salt compound is from saturated or unsaturated alkyl of C6-C18. The saturated or unsaturated alkyl of C6-C18 is animal fat alkyl.
The nonionic surfactant is dodecyl dihydroxyethyl betaine.
The composite sterilizing disinfectant also comprises a biguanide compound, and the ratio of the biguanide compound to the dialkyl dimethyl quaternary ammonium salt compound is 1: 1.
The biguanide compound is chlorhexidine or alexidine.
The preparation method of the composite sterilizing disinfectant has the innovation points that the preparation method comprises the following steps:
the method comprises the following steps: respectively putting C12-16 alkyl benzyl dimethyl ammonium chloride, dialkyl dimethyl quaternary ammonium salt compound and polyvinyl alcohol into deionized water, stirring for 30 minutes, adding dodecyl dihydroxy ethyl betaine after dissolution, continuously dissolving, adjusting the pH value of the solution to 5.5 by using citric acid, and filtering to remove impurities;
step two: respectively adding nano zinc oxide and chitosan into deionized water, stirring and dissolving, adjusting the pH value of the solution to 5.5 by using citric acid, and filtering to remove impurities;
step three: and (3) fully mixing the mixture obtained in the first step with the mixture obtained in the second step, adjusting the pH to 5.5 by using citric acid, adding essence, and adding a small amount of table salt to adjust the viscosity of the solution to 1.5(pa.s.25 ℃).
Specifically, in the second step, the stirring and dissolving time is 1 h.
Comparative example 2
A composite sterilizing disinfectant comprises the following raw materials in percentage by weight: 12 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 7 wt% of polyvinyl alcohol, 12 wt% of nonionic surfactant, 3 wt% of nano zinc oxide, 3 wt% of chitosan, 0.4 wt% of essence and the balance of deionized water.
The alkyl in the dialkyl dimethyl quaternary ammonium salt compound is from saturated or unsaturated alkyl of C6-C18. The saturated or unsaturated alkyl of C6-C18 is animal fat alkyl.
The nonionic surfactant is dodecyl dihydroxyethyl betaine.
The composite sterilizing disinfectant also comprises a biguanide compound, and the ratio of the biguanide compound to the dialkyl dimethyl quaternary ammonium salt compound is 1: 1.
The biguanide compound is chlorhexidine or alexidine.
The preparation method of the composite sterilizing disinfectant has the innovation points that the preparation method comprises the following steps:
the method comprises the following steps: respectively putting C12-16 alkyl benzyl dimethyl ammonium chloride, dialkyl dimethyl quaternary ammonium salt compound and polyvinyl alcohol into deionized water, stirring for 30 minutes, adding dodecyl dihydroxy ethyl betaine after dissolution, continuously dissolving, adjusting the pH value of the solution to 5.5 by using citric acid, and filtering to remove impurities;
step two: respectively adding nano zinc oxide and chitosan into deionized water, stirring and dissolving, adjusting the pH value of the solution to 5.5 by using citric acid, and filtering to remove impurities;
step three: and (3) fully mixing the mixture obtained in the first step with the mixture obtained in the second step, adjusting the pH to 5.5 by using citric acid, adding essence, and adding a small amount of table salt to adjust the viscosity of the solution to 1.5(pa.s.25 ℃).
Specifically, in the second step, the stirring and dissolving time is 1 h.
Comparative example 3
A composite sterilizing disinfectant comprises the following raw materials in percentage by weight: 12 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 12 wt% of dialkyl dimethyl quaternary ammonium salt compound, 7 wt% of polyvinyl alcohol, 3 wt% of nano zinc oxide, 3 wt% of chitosan, 0.4 wt% of essence and the balance of deionized water.
The alkyl in the dialkyl dimethyl quaternary ammonium salt compound is from saturated or unsaturated alkyl of C6-C18. The saturated or unsaturated alkyl of C6-C18 is animal fat alkyl.
The nonionic surfactant is dodecyl dihydroxyethyl betaine.
The composite sterilizing disinfectant also comprises a biguanide compound, and the ratio of the biguanide compound to the dialkyl dimethyl quaternary ammonium salt compound is 1: 1.
The biguanide compound is chlorhexidine or alexidine.
The preparation method of the composite sterilizing disinfectant has the innovation points that the preparation method comprises the following steps:
the method comprises the following steps: respectively putting C12-16 alkyl benzyl dimethyl ammonium chloride, dialkyl dimethyl quaternary ammonium salt compound and polyvinyl alcohol into deionized water, stirring for 30 minutes, adding dodecyl dihydroxy ethyl betaine after dissolution, continuously dissolving, adjusting the pH value of the solution to 5.5 by using citric acid, and filtering to remove impurities;
step two: respectively adding nano zinc oxide and chitosan into deionized water, stirring and dissolving, adjusting the pH value of the solution to 5.5 by using citric acid, and filtering to remove impurities;
step three: and (3) fully mixing the mixture obtained in the first step with the mixture obtained in the second step, adjusting the pH to 5.5 by using citric acid, adding essence, and adding a small amount of table salt to adjust the viscosity of the solution to 1.5(pa.s.25 ℃).
Specifically, in the second step, the stirring and dissolving time is 1 h.
The results of the performance tests of the examples and comparative examples are set forth below:
testing one: the results of the air microbial cultures 30min before and 60min after sterilization with the disinfectant of the present invention are shown in Table 1.
TABLE 1
| Numbering | Before disinfection (cfu/m)3) | After disinfection (cfu/m)3) | The killing rate of bacteria% |
| Example 1 | 670 | 33 | 95.07 |
| Example 2 | 671 | 32 | 95.23 |
| Example 3 | 666 | 32 | 95.20 |
| Example 4 | 678 | 30 | 95.58 |
| Comparative example 1 | 664 | 114 | 82.83 |
| Comparative example 2 | 675 | 99 | 85.33 |
| Comparative example 3 | 672 | 101 | 84.97 |
The result shows that the compound sterilizing disinfectant has good effect of killing bacteria. It was also found through the experiments that the germicidal sterilant prepared in the examples 1-4 of the present invention has far better disinfection effect than the comparative examples 1 and 2 in which the C12-16 alkyl benzyl dimethyl ammonium chloride or dialkyl dimethyl quaternary ammonium salt compound is omitted and the comparative example 3 in which the nonionic surfactant is omitted.
And (2) testing: the same culture medium was treated with escherichia coli, pseudomonas aeruginosa and staphylococcus aureus, respectively, and then placed in the disinfectant prepared according to the formulations of examples 1-4 and comparative examples 1-3 of the present invention, respectively, for 10 minutes, and the sterilization rates of each formulation on escherichia coli, pseudomonas aeruginosa and staphylococcus aureus were counted and recorded in table 2.
TABLE 2
| Numbering | Escherichia coli | Pseudomonas aeruginosa | Staphylococcus aureus |
| Example 1 | 100％ | 100％ | 100％ |
| Example 2 | 100％ | 100％ | 100％ |
| Example 3 | 100％ | 100％ | 100％ |
| Example 4 | 100％ | 100％ | 99.9 |
| Comparative example 1 | 99.1％ | 99.1％ | 99.0％ |
| Comparative example 2 | 99.5％ | 99.4％ | 99.5％ |
| Comparative example 3 | 99.8％ | 99.8％ | 99.7％ |
As can be seen from the above examples, the omission of C12-16 alkylbenzyldimethylammonium chloride or dialkyldimethylammonium quaternary compound or nonionic surfactant, respectively, affects the bactericidal effect and bactericidal strength in a short time.
While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.
Claims (10)
1. The composite sterilizing disinfectant is characterized by comprising the following raw materials in percentage by weight: 5-20 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 5-20 wt% of dialkyl dimethyl quaternary ammonium salt compound, 5-10 wt% of polyvinyl alcohol, 5-20 wt% of nonionic surfactant, 1-5 wt% of nano zinc oxide, 1-5 wt% of chitosan, 0.2-0.6 wt% of essence and the balance of deionized water.
2. The composite bactericidal disinfectant as claimed in claim 1, which is characterized by comprising the following raw materials in percentage by weight: 10-15 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 10-15 wt% of dialkyl dimethyl quaternary ammonium salt compound, 6-8 wt% of polyvinyl alcohol, 10-15 wt% of nonionic surfactant, 2-3 wt% of nano zinc oxide, 2-3 wt% of chitosan, 0.3-0.5 wt% of essence and the balance of deionized water.
3. The composite bactericidal disinfectant as claimed in claim 1 or 2, which is characterized by comprising the following raw materials in percentage by weight: 12 wt% of C12-16 alkyl benzyl dimethyl ammonium chloride, 12 wt% of dialkyl dimethyl quaternary ammonium salt compound, 7 wt% of polyvinyl alcohol, 12 wt% of nonionic surfactant, 3 wt% of nano zinc oxide, 3 wt% of chitosan, 0.4 wt% of essence and the balance of deionized water.
4. The compound disinfectant as claimed in claim 1, wherein the alkyl group of said dialkyl dimethyl quaternary ammonium salt compound is derived from saturated or unsaturated alkyl groups having C6-C18.
5. The composite bactericidal disinfectant of claim 4, wherein the saturated or unsaturated alkyl of C6-C18 is one or a mixture of any two of animal fat alkyl, coconut oil alkyl and soybean oil alkyl.
6. The composite germicidal disinfectant as claimed in claim 1, wherein said non-ionic surfactant is dodecyl dihydroxy ethyl betaine.
7. The composite bactericidal disinfectant according to claim 1, further comprising a biguanide compound, wherein the ratio of the biguanide compound to the dialkyl dimethyl quaternary ammonium salt compound is 1: 1-2.
8. The composite bactericidal disinfectant of claim 7, wherein said biguanide compound is chlorhexidine or alexidine.
9. A method for preparing the composite germicidal disinfectant as claimed in claim 1, characterized in that it comprises the following steps:
the method comprises the following steps: respectively putting C12-16 alkyl benzyl dimethyl ammonium chloride, dialkyl dimethyl quaternary ammonium salt compound and polyvinyl alcohol into deionized water, stirring for 30-60 minutes, adding dodecyl dihydroxy ethyl betaine after dissolution, continuously dissolving, adjusting the pH value of the solution to 5.5-6.5 by using citric acid, and filtering to remove impurities;
step two: respectively adding nano zinc oxide and chitosan into deionized water, stirring and dissolving, adjusting the pH value of the solution to 5.5-6.7 by using citric acid, and filtering to remove impurities;
step three: and (3) fully mixing the mixture in the step one and the mixture in the step two, adjusting the pH to 5.5-6.7 by using citric acid, then adding essence, and adding a small amount of table salt to adjust the viscosity of the solution to 1.5-2(pa.s.25 ℃).
10. The method for preparing the composite germicidal disinfectant as claimed in claim 9, wherein in the second step, the time for stirring and dissolving is 1-1.5 h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911380351.9A CN111109259A (en) | 2019-12-27 | 2019-12-27 | Composite sterilizing disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911380351.9A CN111109259A (en) | 2019-12-27 | 2019-12-27 | Composite sterilizing disinfectant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111109259A true CN111109259A (en) | 2020-05-08 |
Family
ID=70504553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911380351.9A Pending CN111109259A (en) | 2019-12-27 | 2019-12-27 | Composite sterilizing disinfectant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111109259A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112106785A (en) * | 2020-09-10 | 2020-12-22 | 浠昏蕉 | Formula of nano physical composite bactericidal and bacteriostatic agent and preparation method thereof |
| CN115226708A (en) * | 2022-06-01 | 2022-10-25 | 珠海量致科技有限公司 | Zinc oxide dispersion liquid for antibiosis, preparation method and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1277403A1 (en) * | 2001-07-17 | 2003-01-22 | Bode Chemie GmbH & Co. | Disinfectant concentrate based on quaternary ammonium compounds and its use for automated instrument disinfection |
| DE102006051559A1 (en) * | 2006-11-02 | 2008-05-08 | Merz Pharma Gmbh & Co. Kgaa | Cleaning- and disinfectant- concentrate, useful in hygienic surfaces and medical area, preferably medical instruments and composite materials, comprises water, cationic biocidal active agents, amines and heterocyclic components |
| CN101352164A (en) * | 2008-08-15 | 2009-01-28 | 陈波 | Novel compound quaternary ammonium salt disinfectant and preparation method |
| CN101492632A (en) * | 2009-03-02 | 2009-07-29 | 上海九誉生物科技有限公司 | Composite disinfection detergent |
| US20100323895A1 (en) * | 2008-03-16 | 2010-12-23 | Garner Goerge V | Cleaning, sanitising and sterilising preparations |
| GB2474017A (en) * | 2009-09-29 | 2011-04-06 | Europ First Aid Ltd | Biocidal solution |
| US20150282480A1 (en) * | 2014-04-08 | 2015-10-08 | Lonza, Inc. | Fast acting disinfection composition |
-
2019
- 2019-12-27 CN CN201911380351.9A patent/CN111109259A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1277403A1 (en) * | 2001-07-17 | 2003-01-22 | Bode Chemie GmbH & Co. | Disinfectant concentrate based on quaternary ammonium compounds and its use for automated instrument disinfection |
| DE102006051559A1 (en) * | 2006-11-02 | 2008-05-08 | Merz Pharma Gmbh & Co. Kgaa | Cleaning- and disinfectant- concentrate, useful in hygienic surfaces and medical area, preferably medical instruments and composite materials, comprises water, cationic biocidal active agents, amines and heterocyclic components |
| US20100323895A1 (en) * | 2008-03-16 | 2010-12-23 | Garner Goerge V | Cleaning, sanitising and sterilising preparations |
| CN101352164A (en) * | 2008-08-15 | 2009-01-28 | 陈波 | Novel compound quaternary ammonium salt disinfectant and preparation method |
| CN101492632A (en) * | 2009-03-02 | 2009-07-29 | 上海九誉生物科技有限公司 | Composite disinfection detergent |
| US20100222433A1 (en) * | 2009-03-02 | 2010-09-02 | Jialu Xue | Composite Disinfectant Cleaner |
| GB2474017A (en) * | 2009-09-29 | 2011-04-06 | Europ First Aid Ltd | Biocidal solution |
| US20150282480A1 (en) * | 2014-04-08 | 2015-10-08 | Lonza, Inc. | Fast acting disinfection composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112106785A (en) * | 2020-09-10 | 2020-12-22 | 浠昏蕉 | Formula of nano physical composite bactericidal and bacteriostatic agent and preparation method thereof |
| CN115226708A (en) * | 2022-06-01 | 2022-10-25 | 珠海量致科技有限公司 | Zinc oxide dispersion liquid for antibiosis, preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6921745B2 (en) | Bactericidal composition comprising polylysine and a plant essential oil | |
| US20070190177A1 (en) | Zinc composition and their use in anti-microbial applications | |
| EP3500102B1 (en) | Anti-microbial composition | |
| CN111449093A (en) | Natural essential oil composition with antibacterial and disinfecting effects and application thereof | |
| EP2346324A2 (en) | Antimicrobial composition and methods of making and using same | |
| JP6025262B2 (en) | Synergistic disinfecting composition comprising essential oil | |
| CN113491709B (en) | Multifunctional high-efficiency compound disinfectant and preparation method thereof | |
| US11553714B2 (en) | Anti-microbial compositions comprising quaternary organosilane compounds | |
| US20210000107A1 (en) | Antimicrobial composition | |
| CN111109259A (en) | Composite sterilizing disinfectant | |
| CN102318625A (en) | Preparation of leather composite bactericidal mould inhibitor | |
| CN113694082A (en) | Hypochlorous acid disinfectant and preparation method thereof | |
| CN110839643A (en) | Pesticide composition for preventing and treating plant diseases and preparation method thereof | |
| CN111328811B (en) | Low-concentration alcohol sterilization disinfectant and application thereof | |
| CN108728261B (en) | Environment-friendly physical bacteriostatic lotion and application thereof | |
| CN112931542A (en) | Pure plant disinfectant and preparation method thereof | |
| CN111838203A (en) | Cloud rose aromatherapy disinfection spray and preparation method thereof | |
| KR101859924B1 (en) | A cleaning composition containing glyceryl monodecenoate | |
| CN110506738A (en) | A kind of efficient sterilizing air cleaning spray | |
| KR20200108377A (en) | Antiseptic Composition and wet wipes comprising the same | |
| US20210251260A1 (en) | Methanoic acid composition and its uses thereof | |
| KR20200001047A (en) | Composition of natural-borne antifungals and moisturizers | |
| CN110352985B (en) | Composition containing bacillus subtilis and prochloraz and application thereof | |
| CN107714497A (en) | A kind of no added preservative used for cosmetic | |
| CN106577797A (en) | Preparation method of plant disinfectant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200508 |