CN106234439B - A kind of superbacteria antibiosis and sterilization agent and its preparation method and application - Google Patents
A kind of superbacteria antibiosis and sterilization agent and its preparation method and application Download PDFInfo
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- CN106234439B CN106234439B CN201610648777.8A CN201610648777A CN106234439B CN 106234439 B CN106234439 B CN 106234439B CN 201610648777 A CN201610648777 A CN 201610648777A CN 106234439 B CN106234439 B CN 106234439B
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- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/26—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/34—Rosaceae [Rose family], e.g. strawberry, hawthorn, plum, cherry, peach, apricot or almond
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Abstract
The present invention provides a kind of superbacteria antibiosis and sterilization agent and its preparation method and application, each component and its content in the antibiosis and sterilization agent are as follows: 1~100g/L of compound ion anti-biotic material, 10~15g/L of dihydroxy polydiphenylsiloxane of ZnO Modified, 1~100g/L of film forming agent, 1~100g/L of thickener, 1~10g/L of plant extract agent, 1~10g/L of solubilizer, 1~10g/L of freshener and surplus are water.Superbacteria antibiosis and sterilization agent provided by the invention can kill methicillin-resistant staphylococcus aureus (superbacteria), Escherichia coli, Legionella, pyococcus, hepatitis virus, Candida albicans and all kinds of epidemic infectious diseases of staphylococcus aureus and bacterial spore etc..Article surface and environment disinfected and epidemic-stricken area suitable for high-speed rail, aircraft, steamer, subway, hospital, school, kindergarten, large-scale stadium, large-scale recreational facilities and other public places sterilize.
Description
Technical field
The invention belongs to medical preparation field, it is related to a kind of antibiosis and sterilization agent and its preparation method and application, more particularly to
A kind of superbacteria antibiosis and sterilization agent of broad-spectrum high efficacy type and its preparation method and application.
Background technique
In recent years, due to the abuse of antibiotic, lead to the appearance of ultra-fine bacterium, at present MRSA (methicillin-resistant staphylococcus
Staphylococcus) one of highest inside-hospital infection pathogen of global incidence is had become, MRSA infection is listed in the world 3 and is most difficult to greatly
The infectious diseases (MRSA, hepatitis B, HIV infection) of solution is the first.Bacterial drug resistance problem is very serious.In flourishing state
Family, has 5~10% inpatient that one or more infection occurred.The patient that nosocomial infection occurs every year for the U.S. is about
2000000, dead 90000 people, economic loss is up to 45~5,700,000,000 dollars.In developing country, the danger that nosocomial infection occurs wants high
2~20 times of developed country out.Chinese Hospitals infection rate is 6% or so, but rate of failing to report is very high, up to 50% or more.2007
1 part of government's survey report of the year U.S.'s " American Journal of Medicine " weekly publication is said, annual to expect to have more than 90,000 people's severe infections
MRSA.Pointed by Dutch National Public Health and Environmental Studies, the whole world may have up to 53,000,000 people with fatal super disease
Bacterium MRSA.2010, statistics display, in the case of India and Pakistan's confirmation infection " superbacteria " up to 150, Britain
Also there are 70, furthermore European Austria, Belgium, Germany, Holland, Norway, Sweden, France, the Canada and the U.S. of North America,
There are confirmation case in varying numbers in the Kenya in Africa, the states such as Japan, the Singapore in Asia.According to incompletely statistics, Japan, bar
West and Britain are respectively because of its lethal 27 people, 18 people and 5 people.Chinese Center for Disease Control and Prevention on October 26 notification three in 2010
The super antibiotic resistant bacterial pathogens case of infection is played, wherein dead 1.2014 CHINET (Chinese bacterial drug resistance monitoring) to the country
The investigation of 18 large hospitals, the first six digits that superbacteria is firmly infected in occupation of clinical bacteria, and the drug resistance of bacterium is year by year
Go up, highest is up to 80% or more.In April, 2015, British government was in newest " national emergency management risk inventory " report middle finger
Out, improper using antibiotic due to doctor, in fact it could happen that " superbacteria " that a variety of pairs of antibiotic develop drug resistance.Once local
Outburst is related to the blood infection event of " superbacteria " on a large scale, it will has 200,000 people impacted, has about 80,000 people in the middle
" may be dead ".In July, 2016, tool " The Beijing News " report, Brazilian Rio Federal University microorganism institute issue a report recently
It accuses and claims, scientific research personnel has found after sample detection by 1 year, and the waters at seabeach exists " super thin at Rio de Janeiro 5
Bacterium ", this kind of bacterium can cause a variety of diseases, and the crowd of especially immunity difference is easy to be infected, this, which undoubtedly gives, to hold
The Rio Olympic Games coverd with one layer of shade.It can thus be seen that superbacteria is ubiquitous, prevention and control are also extremely urgent.
CN 103891766A discloses a kind of disinfectant, constituent mass percent are as follows: and sym-closene 20~
28%, ethyl alcohol 40~50%, chlorite 1~3%, glycerol 1~2%, essence 1~2%, cosolvent 0.1~0.8% and water 25
~35%.Although the disinfectant has stronger antibacterial and antivirus effect, due to using alcohols material high volatility, make
With the bactericidal effect meeting quick disappearance of ethyl alcohol in the process, do not have bacteriostasis, and superbacteria is imitated without significantly sterilization
Fruit.
Therefore, study a kind of not volatile, persistence is strong, and to superbacteria (such as methicillin-resistant staphylococcus grape ball
Bacterium etc.) the problem of there is the antibiosis and sterilization agent of good bactericidal effect to be urgent need to resolve.
Summary of the invention
Cause bactericidal property to decline for active principle is volatile existing for existing alcohols fungicide, and burning thing easily occurs
Therefore and lead to human skin allergy, the present invention provides a kind of superbacteria antibiosis and sterilization agent and preparation method thereof and
Purposes.Antibiosis and sterilization agent of the present invention can form protecting film in body surface, play the antibacterial effect of sustained anti-microbial；Also,
The antibiosis and sterilization agent is made using the collaboration of compound ion anti-biotic material and the dihydroxy polydiphenylsiloxane of ZnO Modified
With good bactericidal effect being made it have, to methicillin-resistant staphylococcus aureus (superbacteria represents bacterium), large intestine bar
Bacterium, Legionella, pyococcus, hepatitis virus and Candida albicans and all kinds of epidemic infectious diseases and bacterial spore etc. have
Stronger bactericidal effect.
To achieve this purpose, the present invention adopts the following technical scheme:
In a first aspect, the present invention provides a kind of antibiosis and sterilization agent, each component and its content in the antibiosis and sterilization agent are as follows:
Wherein, the content of compound ion anti-biotic material can for 1g/L, 10g/L, 20g/L, 30g/L, 40g/L, 50g/L,
60g/L, 70g/L, 80g/L, 90g/L or 100g/L etc., it is not limited to cited numerical value, other interior numerical value of listed range
It is feasible；The content of the dihydroxy polydiphenylsiloxane of ZnO Modified can 10g/L, 11g/L, 12g/L, 13g/L, 14g/L
Or 15g/L etc., it is not limited to cited numerical value, other interior numerical value of listed range are feasible；The content of film forming agent can be
1g/L, 10g/L, 20g/L, 30g/L, 40g/L, 50g/L, 60g/L, 70g/L, 80g/L, 90g/L or 100g/L etc., but simultaneously not only
It is limited to cited numerical value, other numerical value are feasible in listed range；The content of thickener can for 1g/L, 10g/L, 20g/L,
30g/L, 40g/L, 50g/L, 60g/L, 70g/L, 80g/L, 90g/L or 100g/L etc., it is not limited to cited numerical value,
Other numerical value are feasible in listed range；The content of plant extract agent can for 1g/L, 2g/L, 3g/L, 4g/L, 5g/L, 6g/L,
7g/L, 8g/L, 9g/L or 10g/L etc., it is not limited to cited numerical value, other interior numerical value of listed range are feasible；Increase
The content of solvent can be for 1g/L, 2g/L, 3g/L, 4g/L, 5g/L, 6g/L, 7g/L, 8g/L, 9g/L or 10g/L etc., but simultaneously not only
It is limited to cited numerical value, other numerical value are feasible in listed range；The content of freshener can be 1g/L, 2g/L, 3g/L, 4g/
L, 5g/L, 6g/L, 7g/L, 8g/L, 9g/L or 10g/L etc., it is not limited to cited numerical value, other interior numbers of listed range
It is worth feasible.
In the present invention, the Antibacterial Mechanism of compound ion anti-biotic material be by with microbial cell film surface anion binding
Cell is progressed into, or is reacted with groups such as the sulfydryls of cell surface, the synthesis system of protein and cell membrane is destroyed, is inhibited micro-
The breeding of biology has bacteriostasis.
But simple addition compound ion anti-biotic material is not able to satisfy antibiosis and sterilization agent and wants on Durability of antimicrobial effect
It asks, the present invention improves the wetting of compound ion anti-biotic material by the dihydroxy polydiphenylsiloxane of addition ZnO Modified
Property and affinity, while exciting the anti-microbial property of compound ion anti-biotic material.The present invention using compound ion anti-biotic material and receives
The synergistic effect of rice ZnO modified dihydroxy polydiphenylsiloxane makes antibiosis and sterilization agent obtained have both good antibiotic property
Energy and persistence.
In the present invention, the content of the dihydroxy polydiphenylsiloxane of ZnO Modified need to be kept in a certain range, if
The content of the dihydroxy polydiphenylsiloxane of ZnO Modified is more than 10~15g/L, is unable to reach required effect.
In the present invention, the dihydroxy polydiphenylsiloxane of the ZnO Modified is with nano-ZnO in dihydroxy poly- two
What the growth grafting of phenyl siloxane surface obtained, preparation method are as follows:
Firstly, dispersing nano-ZnO in dihydroxy polydiphenylsiloxane lotion, 1~2h of ultrasonic disperse, dispersion is made
Liquid；Dispersion liquid is added in the closed container with reflux condenser and blender again, 40~50 DEG C is then heated to, stirs back
5~8h is flowed, the dihydroxy polydiphenylsiloxane of ZnO Modified is obtained；Wherein, the nano-ZnO and the poly- hexichol of dihydroxy
The mass ratio of radical siloxane lotion is 1:(5~8).
In the present invention, essence and moisturizer can be also added into antibiosis and sterilization agent.
It is used as currently preferred technical solution below, but not as the limitation of technical solution provided by the invention, passes through
Following technical scheme can preferably reach and realize technical purpose and beneficial effect of the invention.
As currently preferred technical solution, each component and its content in the antibiosis and sterilization agent are as follows:
Preferably, each component and its content in the antibiosis and sterilization agent are as follows:
As currently preferred technical solution, the compound ion anti-biotic material is by ionic liquid and inorganic nano stratification
The progress intercalation assembling of object alpha-phosphate hydrogen zirconium is closed to be prepared；The preparation method of the compound ion anti-biotic material is CN
Preparation method described in 102113484A under normal pressure mixes ionic liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
It closes stirring and ion-exchange reactions occurs, be then centrifuged for separating, wash, be dried to obtain compound ion anti-biotic material.
Preferably, the ionic liquid be quaternary ammonium ion liquid and/or quaternary phosphonium ion liquid, further preferably quaternary ammonium from
Sub- liquid；In the present invention, the compound ion that is prepared with quaternary ammonium ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
The effect that the synergistic effect of anti-biotic material and the dihydroxy polydiphenylsiloxane of ZnO Modified reaches is best.
Preferably, the molar ratio of the ionic liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium is 1:(2~5), example
Such as 1:2,1:3,1:4 or 1:5, it is not limited to cited numerical value, other interior numerical value of listed range are feasible.Experiment card
It is anti-that the molar ratio of bright ionic liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium can be obtained compound ion within this range
Bacterium material has more excellent anti-microbial property, further preferably 1:3.
Preferably, the quality of the compound ion anti-biotic material and the dihydroxy polydiphenylsiloxane of ZnO Modified
Than for 4:1.In the present invention, with the quality of compound ion anti-biotic material and the dihydroxy polydiphenylsiloxane of ZnO Modified
Than for antibiosis and sterilization agent best performance made from 4:1.
As currently preferred technical solution, the film forming agent is polyvinyl alcohol, 2,2,4- trimethyl -1,3- pentanediols
Any one in mono isobutyrate, propandiol butyl ether, propylene glycol methyl ether acetate, diacetone alcohol or dimethyl ether or extremely
Few two kinds of combination, the combination is typical but non-limiting example has: polyvinyl alcohol and 2,2,4- trimethyl -1,3- pentanediol lists
The combination of the combination of isobutyrate, propandiol butyl ether and propylene glycol methyl ether acetate, diacetone alcohol and dimethyl ether
Combination, polyvinyl alcohol, 2, the combination of 2,4- trimethyl -1,3- pentanediol mono isobutyrates and propandiol butyl ether, polyvinyl alcohol, 2,
2,4- trimethyl -1,3- pentanediol mono isobutyrate, propandiol butyl ether, propylene glycol methyl ether acetate, diacetone alcohol and dipropyl two
The combination etc. of diethylene glycol dimethyl ether, further preferably 2,2,4- trimethyl -1,3- pentanediol mono isobutyrates.
As currently preferred technical solution, the thickener is sodium carboxymethylcellulose, propylene glycol alginate, card
Any one in wave nurse, starch phosphate sodium, chitin, tamarind gum or hydroxypropyl starch ether or at least two combination, institute
It states combination typical case but non-limiting example has: the combination of sodium carboxymethylcellulose and propylene glycol alginate, carbomer, starch phosphorus
The combination of acid esters sodium and chitin, the combination of chitin, tamarind gum and hydroxypropyl starch ether, sodium carboxymethylcellulose, seaweed
The combination of acid propylene glycol ester, carbomer, starch phosphate sodium and chitin, carbomer, starch phosphate sodium, chitin, Luo Wang
The combination of sub- glue and hydroxypropyl starch ether, sodium carboxymethylcellulose, propylene glycol alginate, carbomer, starch phosphate sodium, first
Shell element, tamarind gum and combination of hydroxypropyl starch ether etc., further preferably sodium carboxymethylcellulose.
As currently preferred technical solution, the plant extract agent is grape seed extract, cherry extract, aloe
Any one in extract, ginkgo biloba p.e, Lotus Plumule P.E. or wolfberry fruit extract or at least two combination, the combination
Typical but non-limiting example has: the combination of grape seed extract and cherry extract, cherry extract and aloe extract
Combination, the combination of aloe extract, ginkgo biloba p.e and Lotus Plumule P.E., aloe extract, ginkgo biloba p.e, lotus seeds
The combination of heart extract and wolfberry fruit extract, grape seed extract, cherry extract, aloe extract, ginkgo biloba p.e, lotus
Sub- heart extract and the combination of wolfberry fruit extract etc., further preferably grape seed extract.
As currently preferred technical solution, the solubilizer is polyoxyethylene hardened castor oil, polyoxyethylene caster
Oil, fatty alcohol polyoxyethylene ether, aliphatic alcohol polyethenoxy-polyethenoxy ether, polyoxyethylene sorbitan fatty acid ester or poly-
Any one in fatty acid glyceride or at least two combination, the combination is typical but non-limiting example has: polyoxyethylene
The combination of hardened castor oil and Emulsifier EL-60, fatty alcohol polyoxyethylene ether and aliphatic alcohol polyethenoxy-polyethenoxy ether
Combination, the combination of polyoxyethylene sorbitan fatty acid ester and polyglyceryl fatty acid ester is polyoxyethylene hardened castor oil, poly-
The combination of ethylene oxide castor oil and fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, aliphatic alcohol polyethenoxy-polyoxypropylene
The combination of ether and polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hardened castor oil, Emulsifier EL-60, fatty alcohol
Polyoxyethylene ether, aliphatic alcohol polyethenoxy-polyethenoxy ether, polyoxyethylene sorbitan fatty acid ester and polyglycerol fatty acid
The combination etc. of ester, further preferably polyoxyethylene hardened castor oil.
Preferably, the freshener is menthol, menthyl lactate, N-Ethyl-p-menthane-3-carboxamide, menthyl succinate, N- ethyl-right
Any one in menthyl -3- formamide or 2-Isopropyl-N,2,3-trimethylbutyramide or at least two combination, described group
Closing typical but non-limiting example has: the combination of the combination of menthol and menthyl lactate, N-Ethyl-p-menthane-3-carboxamide and menthyl succinate,
Combination of the N- ethyl-to menthyl -3- formamide and 2-Isopropyl-N,2,3-trimethylbutyramide, menthol, lactic acid peppermint
The combination of ester, N-Ethyl-p-menthane-3-carboxamide and menthyl succinate, menthyl succinate, N- ethyl-are to menthyl -3- formamide and 2- isopropyl
Base-N, the combination of 2,3- trimethylbutyramides, menthol, menthyl lactate, N-Ethyl-p-menthane-3-carboxamide, menthyl succinate, N- ethyl-right
Menthyl -3- formamide and the combination of 2-Isopropyl-N,2,3-trimethylbutyramide etc., further preferably menthyl lactate.
As currently preferred technical solution, each component and its content in the antibiosis and sterilization agent are as follows:
Wherein, compound ion anti-biotic material is carried out by quaternary ammonium ion liquid with inorganic nano layer compound alpha-phosphate hydrogen zirconium slotting
Layer assembling is prepared；The mass ratio of compound ion anti-biotic material and the dihydroxy polydiphenylsiloxane of ZnO Modified is
4:1。
In the present invention, the bactericidal effect of obtained antibiosis and sterilization agent and the protection of formation are prepared with above-mentioned each substance and proportion
Film it is optimal at film persistence.
Second aspect, the present invention provides the preparation method of above-mentioned antibiosis and sterilization agent, the antibiosis and sterilization agent is by with lower section
Method is prepared:
By the compound ion anti-biotic material of formula ratio, the dihydroxy polydiphenylsiloxane of ZnO Modified, film forming agent,
Thickener, plant extract agent, solubilizer, freshener and water are added to the container, and 3~5h is stirred at 100~150 DEG C, system
Obtain antibiosis and sterilization agent.
Wherein, whipping temp can be 100 DEG C, 110 DEG C, 120 DEG C, 130 DEG C, 140 DEG C or 150 DEG C etc., it is not limited to
Cited numerical value, other interior numerical value of listed range are feasible；Mixing time can be 3h, 4h or 5h etc., it is not limited to institute
The numerical value enumerated, other interior numerical value of listed range are feasible.
The third aspect, the present invention provides the purposes of above-mentioned antibiosis and sterilization agent, and antibiosis and sterilization agent is sprayed on wait remove fungus
Body surface face forms protecting film.
Compared with prior art, the invention has the following advantages:
(1) antibiosis and sterilization agent of the present invention can form protection film in body surface, and it is antibacterial to play sustained anti-microbial
Effect；The present invention utilizes the synergistic effect of the dihydroxy polydiphenylsiloxane of compound ion anti-biotic material and ZnO Modified,
Good bactericidal effect is made it have, methicillin-resistant staphylococcus aureus (superbacteria represents bacterium), large intestine bar can be killed
Bacterium, Legionella, pyococcus, hepatitis virus, Candida albicans, all kinds of epidemic infectious diseases and bacterial spore etc., sterilizing rate
95% or more.
(2) the compound ion anti-biotic material in antibiosis and sterilization agent of the present invention is a kind of cheap, environmental-friendly
The compatibility of anti-biotic material and organic material is good；And the antibiosis and sterilization agent is free of toxic component, and non-corrosive, to stainless
The materials such as steel, carbon steel, copper are almost corrosion-free.
(3) antibiosis and sterilization agent of the present invention can replace ethanol disinfection liquid, and Disinfection Effect at low cost is good, have concurrently good
Bacteriostasis.
(4) object of the antibiosis and sterilization agent of the present invention suitable for high-speed rail, aircraft, steamer, subway, automobile and hospital etc.
Product and environment disinfected and epidemic-stricken area disinfection.
Specific embodiment
In order to better illustrate the present invention, it is easy to understand technical solution of the present invention, below further specifically to the present invention
It is bright.But following embodiments is only simple example of the invention, does not represent or limit the scope of the present invention, this
Invention protection scope is subject to claims.
Embodiment 1:
Present embodiments provide a kind of antibiosis and sterilization agent, contain following components in every liter of antibiosis and sterilization agent: compound ion is anti-
Bacterium material 48g, the dihydroxy polydiphenylsiloxane 12g of ZnO Modified, film forming agent 2,2,4- trimethyl -1,3- pentanediol
Mono isobutyrate 45g, thickener sodium carboxymethylcellulose 45g, plant extract agent grape seed extract 6g, solubilizer polyoxyethylene
Hardened castor oil 5g and freshener menthyl lactate 5g, surplus are pure water.
Wherein, compound ion anti-biotic material is carried out using quaternary ammonium ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
Intercalation assembling is prepared, and the molar ratio of quaternary ammonium ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium is 1:3.
Embodiment 2:
Present embodiments provide a kind of antibiosis and sterilization agent, contain following components in every liter of antibiosis and sterilization agent: compound ion is anti-
Bacterium material 20 g, the dihydroxy polydiphenylsiloxane 13g of ZnO Modified, film forming agent propandiol butyl ether 3g, thickener seaweed
Acid propylene glycol ester 6g, plant extract agent cherry extract 3g, solubilizer fatty alcohol polyoxyethylene ether 2g, freshener menthyl lactate
2g and essence 6g, surplus are pure water.
Wherein, compound ion anti-biotic material is carried out using quaternary ammonium ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
Intercalation assembling is prepared, and the molar ratio of quaternary ammonium ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium is 1:2.
Embodiment 3:
Present embodiments provide a kind of antibiosis and sterilization agent, contain following components in every liter of antibiosis and sterilization agent: compound ion is anti-
Bacterium material 40g, the dihydroxy polydiphenylsiloxane 14g of ZnO Modified, film forming agent polyvinyl alcohol 50g, thickener carbomer
20g, plant extract agent cherry extract 4g, solubilizer polyoxyethylene hardened castor oil 3g, freshener menthyl lactate 3g and perfume (or spice)
Smart 3g, surplus are pure water.
Wherein, compound ion anti-biotic material is carried out using quaternary phosphonium ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
Intercalation assembling is prepared, and the molar ratio of quaternary phosphonium ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium is 1:5.
Embodiment 4:
Present embodiments provide a kind of antibiosis and sterilization agent, contain following components in every liter of antibiosis and sterilization agent: compound ion is anti-
Bacterium material 15g, the dihydroxy polydiphenylsiloxane 10g of ZnO Modified, film forming agent propylene glycol methyl ether acetate 2g, thickening
Agent chitin 5g, plant extract agent ginkgo biloba p.e 4g, solubilizer fatty alcohol polyoxyethylene ether 7g, freshener n-ethyl-p-menthane-3-carboxamide
7g, moisturizer vitamin E 20g and essence 2g, surplus are pure water.
The preparation method and materials of the compound ion anti-biotic material are in the same manner as in Example 1.
Embodiment 5:
Present embodiments provide a kind of antibiosis and sterilization agent, contain following components in every liter of antibiosis and sterilization agent: compound ion is anti-
Bacterium material 30g, the dihydroxy polydiphenylsiloxane 15g of ZnO Modified, film forming agent diacetone alcohol 6g, thickener hydroxypropyl
Starch ether 7g, plant extract agent ginkgo biloba p.e 4g, solubilizer fatty alcohol polyoxyethylene ether 10g, freshener n-ethyl-p-menthane-3-carboxamide 1g
With essence 7g, surplus is pure water.
The preparation method and materials of the compound ion anti-biotic material are in the same manner as in Example 1.
Embodiment 6:
Present embodiments provide a kind of antibiosis and sterilization agent, contain following components in every liter of antibiosis and sterilization agent: compound ion is anti-
Bacterium material 60g, the dihydroxy polydiphenylsiloxane 15g of ZnO Modified, film forming agent dimethyl ether 40g, thickener
Hydroxypropyl starch ether 40g, plant extract agent ginkgo biloba p.e 8g, solubilizer fatty alcohol polyoxyethylene ether 3g, freshener n-ethyl-p-menthane-3
Amide 4g and essence 5g, surplus are pure water.
The preparation method and materials of the compound ion anti-biotic material are in the same manner as in Example 1.
Embodiment 7:
Present embodiments provide a kind of antibiosis and sterilization agent, contain following components in every liter of antibiosis and sterilization agent: compound ion is anti-
Bacterium material 60g, the dihydroxy polydiphenylsiloxane 15g of ZnO Modified, film forming agent dimethyl ether 40g, thickener
Hydroxypropyl starch ether 50g, plant extract agent ginkgo biloba p.e 8g, solubilizer fatty alcohol polyoxyethylene ether 3g, freshener n-ethyl-p-menthane-3
Amide 4g and essence 5g, surplus are pure water.
The preparation method and materials of the compound ion anti-biotic material are in the same manner as in Example 1.
Embodiment 8:
The preparation method of antibiosis and sterilization agent in above-described embodiment 1-7 is present embodiments provided, the method is as follows:
By the compound ion anti-biotic material of formula ratio, the dihydroxy polydiphenylsiloxane of ZnO Modified, film forming agent,
Thickener, plant extract agent, solubilizer, freshener and water are added to the container, and 4h is stirred at 130 DEG C, and obtained antibacterial disappears
Toxic agent.
Embodiment 9:
The preparation method of antibiosis and sterilization agent in above-described embodiment 1-7 is present embodiments provided, the method is as follows:
In addition to the temperature being stirred is 100 DEG C, the time being stirred is unclassified stores dosage and preparation step outside 3h
It is in the same manner as in Example 8.
Embodiment 10:
The preparation method of antibiosis and sterilization agent in above-described embodiment 1-7 is present embodiments provided, the method is as follows:
In addition to the temperature being stirred is 150 DEG C, the time being stirred is unclassified stores dosage and preparation step outside 5h
It is in the same manner as in Example 8.
Comparative example 1:
This comparative example provides a kind of antibiosis and sterilization agent, forms the poly- hexichol of dihydroxy in addition to being free of ZnO Modified
Outside radical siloxane, other composition contents are in the same manner as in Example 1.
Comparative example 2:
This comparative example provides a kind of antibiosis and sterilization agent, in addition to the dihydroxy containing ZnO Modified in every liter of antibiosis and sterilization agent
Base polydiphenylsiloxane 5g outer (i.e. dosage is 5g/L), other composition contents are in the same manner as in Example 1.
Comparative example 3:
This comparative example provides a kind of antibiosis and sterilization agent, in addition to the dihydroxy containing ZnO Modified in every liter of antibiosis and sterilization agent
Base polydiphenylsiloxane 20g outer (i.e. dosage is 20g/L), other composition contents are in the same manner as in Example 1.
Antibiosis and sterilization agent in above-described embodiment 1-7 and comparative example 1-3 is tested for the property, tests it to super thin
The bactericidal effect of bacterium methicillin-resistant staphylococcus aureus (MRSA), through Guangdong Province's microbiological analysis Spot detection, test
Results of property is as shown in table 1.
Table 1: antibiosis and sterilization agent performance test table described in embodiment 1-7 and comparative example 1-3
The result of integrated embodiment 1-7 and comparative example 1-3 can be seen that antibiosis and sterilization agent of the present invention can be in object
Surface forms protection film, plays the antibacterial effect of sustained anti-microbial；The present invention is changed using compound ion anti-biotic material and nano-ZnO
Property dihydroxy polydiphenylsiloxane synergistic effect, make it have good bactericidal effect, can kill methicillin-resistant gold
Staphylococcus aureus (superbacteria represents bacterium), Escherichia coli, Legionella, pyococcus, hepatitis virus, Candida albicans,
All kinds of epidemic infectious diseases and bacterial spore etc., sterilizing rate is 95% or more.Meanwhile answering in antibiosis and sterilization agent of the present invention
Conjunction ion antibacterial material is that the compatibility of a kind of cheap, environmental-friendly anti-biotic material and organic material is good；And it is described anti-
Bacterium disinfectant is free of toxic component, and non-corrosive, almost corrosion-free to materials such as stainless steel, carbon steel, copper.
The Applicant declares that the present invention is explained by the above embodiments method detailed of the invention, but the present invention not office
Be limited to above-mentioned method detailed, that is, do not mean that the invention must rely on the above detailed methods to implement.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., all of which fall within the scope of protection and disclosure of the present invention.
Claims (19)
1. a kind of antibiosis and sterilization agent, which is characterized in that each component and its content in the antibiosis and sterilization agent are as follows:
Wherein, the mass ratio of the compound ion anti-biotic material and the dihydroxy polydiphenylsiloxane of ZnO Modified is 4:
1；The compound ion anti-biotic material carries out intercalation assembling by ionic liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium and prepares
It obtains；The ionic liquid is quaternary ammonium ion liquid and/or quaternary phosphonium ion liquid.
2. antibiosis and sterilization agent according to claim 1, which is characterized in that each component and its content in the antibiosis and sterilization agent
Are as follows:
3. antibiosis and sterilization agent according to claim 1 or 2, which is characterized in that in the antibiosis and sterilization agent each component and its
Content are as follows:
4. antibiosis and sterilization agent according to claim 1, which is characterized in that the ionic liquid is quaternary ammonium ion liquid.
5. antibiosis and sterilization agent according to claim 1, which is characterized in that the ionic liquid and inorganic nano layer compound
The molar ratio of alpha-phosphate hydrogen zirconium is 1:(2~5).
6. antibiosis and sterilization agent according to claim 1, which is characterized in that the ionic liquid and inorganic nano layer compound
The molar ratio of alpha-phosphate hydrogen zirconium is 1:3.
7. antibiosis and sterilization agent according to claim 1 or 2, which is characterized in that the film forming agent is polyvinyl alcohol, 2,2,4-
Trimethyl -1,3- pentanediol mono isobutyrate, propandiol butyl ether, propylene glycol methyl ether acetate, diacetone alcohol or dipropylene glycol two
Any one in methyl ether or at least two combination.
8. antibiosis and sterilization agent according to claim 7, which is characterized in that the film forming agent is 2,2,4- trimethyls -1,3-
Pentanediol mono isobutyrate.
9. antibiosis and sterilization agent according to claim 1 or 2, which is characterized in that the thickener be sodium carboxymethylcellulose,
Any one in propylene glycol alginate, carbomer, starch phosphate sodium, chitin, tamarind gum or hydroxypropyl starch ether or
At least two combination.
10. antibiosis and sterilization agent according to claim 9, which is characterized in that the thickener is sodium carboxymethylcellulose.
11. antibiosis and sterilization agent according to claim 1 or 2, which is characterized in that the plant extract agent is grape pip extraction
Any one in object, cherry extract, aloe extract, ginkgo biloba p.e, Lotus Plumule P.E. or wolfberry fruit extract or extremely
Few two kinds of combination.
12. antibiosis and sterilization agent according to claim 11, which is characterized in that the plant extract agent is grape pip extraction
Object.
13. antibiosis and sterilization agent according to claim 1 or 2, which is characterized in that the solubilizer is polyoxyethylene hardened castor
Sesame oil, Emulsifier EL-60, fatty alcohol polyoxyethylene ether, aliphatic alcohol polyethenoxy-polyethenoxy ether, polyoxyethylene sorbitan mountain
Any one in pears alcohol fatty acid ester or polyglyceryl fatty acid ester or at least two combination.
14. antibiosis and sterilization agent according to claim 13, which is characterized in that the solubilizer is polyoxyethylene hardened castor-oil plant
Oil.
15. antibiosis and sterilization agent according to claim 1 or 2, which is characterized in that the freshener is menthol, lactic acid is thin
Lotus ester, N-Ethyl-p-menthane-3-carboxamide, menthyl succinate, N- ethyl-are to menthyl -3- formamide or 2- isopropyl-N, 2,3- trimethyl fourth
Any one in amide or at least two combination.
16. antibiosis and sterilization agent according to claim 15, which is characterized in that the freshener is menthyl lactate.
17. antibiosis and sterilization agent according to claim 1 or 2, which is characterized in that in the antibiosis and sterilization agent each component and its
Content are as follows:
Wherein, compound ion anti-biotic material carries out intercalation group by quaternary ammonium ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
Dress is prepared；The mass ratio of compound ion anti-biotic material and the dihydroxy polydiphenylsiloxane of ZnO Modified is 4:1.
18. the preparation method of -17 described in any item antibiosis and sterilization agents according to claim 1, which is characterized in that the antibacterial disappears
Toxic agent is prepared by following methods:
By the compound ion anti-biotic material, the dihydroxy polydiphenylsiloxane of ZnO Modified, film forming agent, thickening of formula ratio
Agent, plant extract agent, solubilizer, freshener and water are added to the container, and are stirred 3~5h at 100~150 DEG C, are made anti-
Bacterium disinfectant.
19. the purposes of -18 described in any item antibiosis and sterilization agents according to claim 1, which is characterized in that spray antibiosis and sterilization agent
It spills in degerming body surface formation protecting film.
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| CN108077311A (en) * | 2016-11-22 | 2018-05-29 | 北京中科艾利特科技有限公司 | A kind of antimicrobial spray of haze and its preparation method and application |
| CN108078959A (en) * | 2016-11-22 | 2018-05-29 | 北京赛特瑞科技发展有限公司 | A kind of antibacterial and protective film and its preparation method and application |
| CN107788229A (en) * | 2017-07-27 | 2018-03-13 | 浦江县合洪园艺研发有限公司 | A kind of purposes of plant-based bacteriostat |
| CN107410290A (en) * | 2017-09-02 | 2017-12-01 | 惠州市锦恒工业模具设计合伙企业(普通合伙) | A kind of agricultural composite medicine fresh-keeping for lily cut flowers |
| CN109464621A (en) * | 2018-11-23 | 2019-03-15 | 广西信业生物技术有限公司 | A kind of external preparation and preparation method thereof for treating eczema |
| CN111084183A (en) * | 2019-12-30 | 2020-05-01 | 江苏神涛环保科技有限公司 | Fabric surface antibacterial disinfectant and preparation method thereof |
| ES2971183A1 (en) * | 2023-12-20 | 2024-06-03 | Univ Santiago Compostela | WHITE GRAPE EXTRACT, TOPICAL ANTIBACTERIAL FORMULATION THAT CONTAINS IT, OBTAINING PROCEDURE AND USES OF THE SAME |
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| CN102113484A (en) * | 2010-10-29 | 2011-07-06 | 中国科学院过程工程研究所 | Preparation method of composite anti-bacterium material |
| CN105085857A (en) * | 2015-09-07 | 2015-11-25 | 东莞市吉鑫高分子科技有限公司 | Waterproof breathable antibacterial thermoplastic polyurethane elastomer and preparation method thereof |
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| CN102113484A (en) * | 2010-10-29 | 2011-07-06 | 中国科学院过程工程研究所 | Preparation method of composite anti-bacterium material |
| CN105085857A (en) * | 2015-09-07 | 2015-11-25 | 东莞市吉鑫高分子科技有限公司 | Waterproof breathable antibacterial thermoplastic polyurethane elastomer and preparation method thereof |
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