KR20170009702A - Wet wipes composition and wet wipes containing the same including the troplone - Google Patents

Abstract

The present invention relates to a wet tissue composition comprising tropolone and a wet tissue comprising the same. The wet tissue according to the present invention uses a wet tissue composition comprising tropolone, and thus shows improved resistance against bacteria and molds. In addition, the wet tissue composition according to the present invention significantly reduces or completely avoids the use of a quaternary ammonium compound, such as cetylpyridinium chloride, and thus reduces generation of bubbles from a wet tissue and significantly decreases generation of a pop-up phenomenon. In addition, it is possible to significantly improve the problems of a slippery feeling and diffusivity occurring in the conventional wet tissue obtained by using a preservative composition for a wet tissue comprising cetylpyridinium chloride. Further, it is possible to improve the resistance of tropolone against bacteria and molds by using tropolone in combination with ethylhexyl glycerin.

Description

[0001] The present invention relates to a preservative composition comprising tropolone and a wetting composition containing the same,

The present invention relates to a wet tissue composition comprising tropolone, and more particularly to a wet tissue composition comprising tropolone, which comprises a) tropolone, b) glycines, an alkanediol, an organic acid, hexamidine and A salt or a quaternary ammonium salt, and c) purified water, characterized in that the bacterium Burkholderia sp. Which is spread by a wet tissue has an antibacterial effect. And more particularly to a wet tissue composition comprising the same.

Wet tissue refers to a nonwoven fabric (natural pulp, cotton, tencel, natural fiber fabric, nonwoven fabric, synthetic fiber fabric, blend fabric, etc.) that is used to clean the human body. Due to its portability and ease of use, demand for wet tissues is increasing rapidly.

Types of wipes are classified into various types such as oral wet wipes, infant wet wipes, women's wet wipes, sanitary wet wipes, and multi-purpose wet wipes. This product is not a product to be washed with water after use, so the preservative contained in the product may remain on the skin, and the site of use of the product is sensitive to chemicals such as mouth and hands. It is less irritating to the skin because of direct contact with the skin of the human body, has excellent safety, and has excellent removability against foreign substances and pathogenic microorganisms remaining on the skin.

Cetylpyridinium chloride (CPC), which is the most widely used quaternary ammonia type currently used as a wetting preservative, increases defoaming amount over time and should be used as defoaming agent. In this case, contamination and process trouble It represents various problems. Also, there is a variety of problems such as slippery, a phenomenon in which the popup phenomenon of the wet tissue is increased, and diffusion in the wet tissue is poor and the microorganism is vulnerable to contamination. In addition, during the manufacturing process of the wet tissue, various bacteria are proliferated. Among them, Burkholderia sp. Is infected with the wet tissue by the wet tissue manufacturing facility. Therefore, it is urgent to develop a new preservative for wet tissues that significantly reduces or completely replaces the usage of such quaternary ammonium-based materials such as cetylpyridinium chloride.

As a new wetting agent preservative that significantly reduces or completely replaces the amount of cetylpyridinium chloride is used, the amount of cream barazole, which is often used as a preservative in domestic and overseas cosmetics, is increasing. Climbazole, which is used as a wet tissue preservative, is a white crystalline powder. It is known to be 0 grade in the EWG Skin Deep grades, a non-profit environmental research institute in the US, and has lower irritancy and lower risk than other ingredients. Creambarzole is also known to have an exclusive and persistent germicidal effect on ovarian fungi and tricobacillus, but it is not soluble in water and is a potentially toxic harmful substance.

Gram-negative bacilli are a major cause of hospital infection, and the extent and extent of resistance has recently become more severe, making the choice of empirical antibiotics more difficult. Especially, Gram negative bacillus isolated from Korea is remarkably high in resistance against commonly used antibiotics, and recently, Gram negative bacillus showing resistance to multidrug resistance has also been expanded.

Korean Patent Registration No. 10-1320599 discloses an antibacterial wetting wet tissue produced by mixing purified water with ethylhexyl glycerin, caprylyl glycol, glycerin, and a surfactant. However, the anti- There is a difference in the construction in which pollen and ethyllauryl alginate hydrochloride are not used, and there is an unsatisfactory effect that the wet tissue produced using the above substance has little effect on the antifungal activity.

In addition, Korean Patent Publication No. 10-1525987 (a wet tissue composition and a wet tissue including the wet tissue composition) of the present invention relates to a wet tissue composition containing ethyllauryl alginate hydrochloride. However, since the antifungal activity is insufficient, .

KR 10-1320599 B1 (October 13, 2013) KR 10-1525987 B1 (2015.05.29)

In order to solve the above problems, it is an object of the present invention to provide a wet tissue composition containing tropolone, which can exhibit resistance to various microorganisms occurring in a wet tissue manufacturing process.

Also, it is an object of the present invention to provide a wet tissue composition prepared by mixing tropolone and ethylhexyl glycerin to a wet tissue to improve the resistance to bacterium and fungus possessed by troponin, thereby exhibiting a synergistic effect.

In order to achieve the above object, the present invention provides a wet tissue composition comprising tropolone, which comprises a) tropolone, b) one or more of glycines, alkanediols, organic acids, hexamidine and salts thereof or quaternary ammonium, and c) And purifying water, and is characterized in that it has an antibacterial effect on Burkholderia sp., Which is spread by a wet tissue.

The wipes composition may further comprise: a) from 0.001 to 20% by weight of tropolone; b) from 0.0001 to 20% by weight of one or more of glycines, alkanediols, organic acids, ethyllauryl alginate hydrochloride or quaternary ammonium; and c) To 99.99% by weight.

The wet tissue produced according to the present invention has an effect of improving resistance to bacteria and fungi by producing a wipes composition containing tropolon.

Further, the wipes composition according to the present invention significantly reduces or completely eliminates the use amount of quaternary ammonium such as cetylpyridinium chloride chloride, thereby reducing the amount of bubbles generated in the wet tissue and significantly reducing the occurrence of pop-up phenomenon.

In addition, there is an effect that the problem of slipperiness and diffusibility which have conventionally occurred in the wet tissue produced using the preservative composition for wet tissues containing cetylpyridinium chloride chloride is remarkably improved.

Also, when used in combination with ethylhexyl glycerin, the effect of resistance to bacteria and fungus of tropolone is improved.

The present invention relates to a wet tissue composition comprising tropolone and a wet tissue comprising the same.

The present inventors have intensively studied to develop a wet tissue composition having excellent sterilizing effect and a wet tissue containing the same, and as a result, discovered the wet tissue composition according to the present invention and completed the present invention.

The wet tissue composition comprising tropolone according to the present invention comprises a) tropolone, b) one or more of glycines, alkanediols, organic acids, hexamidine or its salts or quaternary ammonium, and c) purified water , And it is preferable that the bacteria of the genus Burkholderia sp. Infecting the wipes have an antibacterial effect.

The wipes composition may further comprise: a) from 0.001 to 20% by weight of tropolone; b) from 0.0001 to 20% by weight of one or more of glycines, alkanediols, organic acids, hexamidine and salts thereof or quaternary ammonium; and c) Preferably 99.99% by weight.

It is also preferable to prepare a wet tissue containing the above wet tissue composition.

When the wet tissue composition is prepared at less than the content of each of the wet tissue compositions, the effect of the wet tissue composition is insufficient, which may cause the growth of microorganisms, which is undesirable. , The difference in the effect of the wet tissue composition is not large, which is uneconomical and therefore undesirable.

Also, it is preferable that the wettable composition prepared as described above is diluted with distilled water or purified water when preparing the wettable liquid, and the dilution ratio of the wettable composition is from 98.9 to 99.7% by weight of purified water or 0.3 to 1.1% To prepare a wet tissue liquid, and then to prepare a wet tissue including the wet tissue liquid. More preferably, the wet tissue liquid is prepared by mixing 99.6% by weight of purified water with 0.4% by weight of the wet tissue composition.

The Tropolne is registered as a cosmetic raw material and is a safe ingredient with a risk index of 0 in the cosmetic ingredient safety check by EWG, a non-profit environmental NGO in Washington, USA. In addition, tropolone is a preservative, which acts to prevent the degradation or decay of the product due to the growth of microorganisms in cosmetics, and is particularly effective in inhibiting fungi. The tropolone may be represented by the following general formula (1).

Ethylhexyl glycerin is a kind of vegetable glycerin. It is excellent in antibacterial activity against fungi, has excellent moisturizing effect, and has little irritation on the skin, so that it does not cause side effects such as allergies and skin troubles. Ethylhexyl glycerin is also known to have excellent deodorizing effect on skin, and it is widely used in cosmetics.

Also, the ethyl lauroyl arginate HCl (LAE) is a substance that can be used as a preservative composition by replacing quaternary ammonium-based materials such as conventional cetylpyridinium chloride used in a preservative composition for a wet tissue , And as a safe preservative used as a food preservative. Although it is a safe substance used for cosmetics, it is not known if it is applied to wet tissues at a high price. The ethyllauryl alginate hydrochloride may be represented by the following formula (2).

The wet tissue composition prepared according to the present invention has an effect of improving resistance to bacteria and fungi in a wet tissue composition containing tropolone.

In addition, by using the wet tissue composition prepared above, a wet tissue liquid is produced to enhance the antimicrobial effect, and a wet tissue composition containing ethylhexyl glycerin is produced to give a synergistic effect to effectively inhibit major microorganisms such as fungi and bacteria .

Also, it is preferable to mix one or more of glycine systems composed of undecylenolyl glycine or capryloylglycine with the tropolone to prepare a wet tissue composition, and the glycine system preferably contains 0.0001 to 20 wt% . Among the above-mentioned glycine compounds, the undecylenoylglycine is an acylate of glycine and undecylenic acid chloride, and the capryloylglycine is a substance which acylates glycine with caprylic acid chloride.

Also, it is preferable to mix one or more of the alkane diols composed of the octanediol or hexanediol with the tropolone to prepare the wet tissue composition, and the alkane diol preferably contains 0.0001 to 20 wt%. The hexanediol is widely used as a substitute for parabens, and is widely used as a preservative for various cosmetics or extracts because of its excellent moisturizing and antibacterial properties. It has little irritation as compared with antibacterial activity and is known to have excellent usability such as water and alcohol.

It is also preferable to mix one or more of quaternary ammoniums composed of alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride or alkyldimethylmethlamylammonium chloride with tropolone to prepare a wet tissue composition, and the quaternary ammonium Is preferably 0.0001 to 20% by weight. The quaternary ammonium has a wide range of disinfecting power for bacteria, viruses, fungi, protozoa and algae, and is characterized by its surface activating action. The quaternary ammonium exhibits a positive charge and has an effect of colliding with a bacteria or a virus showing a negative charge by an electric suction force, has no corrosiveness, and has little influence on temperature and pH.

Hereinafter, preferred embodiments, comparative examples, and experimental examples are provided to facilitate understanding of the present invention. It should be understood, however, that the following examples, comparative examples and experimental examples are provided only to facilitate understanding of the present invention, and that the present invention is not limited to the following examples, comparative examples and experimental examples.

Experimental Example 1: Microbial minimum inhibitory concentration

The antimicrobial effect of each substance used in the present invention on bacteria and fungi was measured by MIC (Minimum inhibition concentration: 2-fold dilution method) and the results are shown in Table 1 below. A test organism is Staphylococcus aureus (Staphylococcus aureus), Pseudomonas aeruginosa (Pseudomonas aeruginosa), E. coli (Escherichia coli), Candida albicans (Candida albicans , Burkholderia cepacia and Aspergillus niger were tested.

Minimum inhibitory concentration (MIC) Staphylococcus P. aeruginosa Escherichia coli Candida
Albikans Burg Helderia Sepassia Black mold Troponone 160 160 40 160 160 20

unit; ppm

Trojan polron is Staphylococcus aureus (Staphylococcus aureus) As shown in Table 1, Pseudomonas aeruginosa (Pseudomonas aeruginosa , Escherichia coli), Candida albicans (Candida albicans) and Burkholderia Sefar Asia (Burkholderia The antimicrobial and antifungal activity of cepacia was 40 ~ 160ppm, but the antifungal activity of Aspergillus niger was 20ppm.

As a result, tropolone was contained in the wet tissue preservative to enhance the antimicrobial and antifungal effect of the wet tissue preservative, and to use synergistic effect by using ethylhexyl glycerin together.

Experimental Example 2: Preparation of Wet Tissue Composition

The wet tissue composition was prepared by mixing each composition as shown in the following Table 1, and then 0.4 wt% of the prepared wet tissue preservative composition was diluted to 99.6 wt% of distilled water.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Troponone 10 wt% 10 wt% 10 wt% 10 wt% - - - - Ethylhexyl glycerin 15 wt% 15 wt% 15 wt% 15 wt% - - - - Hexylene glycol 30 wt% 30 wt% 30 wt% 30 wt% - 10 wt% 5 wt% 10 wt% Ethyl Lauroyl Alginate Hydrochloride - - 5 wt% - - - 5 wt% - Cetylpyridinium chloride - - - - 15 wt% 10 wt% 15 wt% 10 wt% Caprylyl glycoll 5 wt% - - 5 wt% - 5 wt% - - Sodium benzoate - - - 10 wt% 10 wt% - - 10 wt%

Example

Example 1

10% by weight of Tropolone (TP), 15% by weight of ethylhexyl glycerin, 30% by weight of hexylene glycol, 5% by weight of caprylryl glycol, 40% by weight to prepare a preservative composition for a wet tissue.

Example 2

10 parts by weight of tropolone (TP), 15 parts by weight of ethylhexyl glycerin, 30 parts by weight of hexylene glycol and 45 parts by weight of purified water were mixed to prepare a preservative composition for a wet tissue Respectively.

Example 3

10 wt% of Tropolone (TP), 15 wt% of Ethylhexyl glycerin, 30 wt% of Hexylene glycol, Ethyl lauroyl arginate HCl (LAE) 5% by weight and purified water 40% by weight to prepare a preservative composition for a wet tissue.

Example 4

10% by weight of Tropolone (TP), 15% by weight of ethylhexyl glycerin, 30% by weight of hexylene glycol, 5% by weight of caprylryl glycol, 10% by weight of sodium benzoate (SB) and 30% by weight of purified water to prepare a preservative composition for a wet tissue.

Comparative Example

Comparative Example 1

15% by weight of hexylene glycol, 10% by weight of sodium benzoate (SB) and 75% by weight of purified water were mixed to prepare a preservative composition for a wet tissue.

Comparative Example 2

10% by weight of cetyl pyridinium chloride, 10% by weight of hexylene glycol, 5% by weight of caprylryl glycol and 75% by weight of purified water, A preservative composition for a wet tissue was prepared.

Comparative Example 3

15% by weight of cetyl pyridinium chloride, 5% by weight of ethyl lauroyl arginate HCl (LAE), 5% by weight of hexylene glycol, and 75% by weight of purified water By weight to prepare a preservative composition for a wet tissue.

Comparative Example 4

10% by weight of cetyl pyridinium chloride, 10% by weight of hexylene glycol, 10% by weight of sodium benzoate (SB) and 70% by weight of purified water, A preservative composition was prepared.

Experimental Example 3: Measurement of microorganism retention capacity of wet tissue

The shaking flask method was used for the antibacterial and antifungal test of the wet tissue compositions according to Examples 1 to 4 and Comparative Examples 1 to 4.

It was placed in a specifically sterilizing wipes each one 100㎖ enough saline solution to elute the tissue, Staphylococcus aureus (Staphylococcus aureus), Pseudomonas aeruginosa (Pseudomonas aeruginosa), E. coli (Escherichia coli ), Candida albicans ( Candida albicans , Burkholderia cepacia), and the black mold (Aspergillus niger), respectively 105-108 and then CFU / ㎖ inoculated to plate culture experiment to determine the loss and death rate of bacteria and then counting the number of colonies was measured mortality rate.

Dead rate (reduction rate) = (number of controls - number of samples) / number of controls × 100

The results measured according to the calculation of the mortality rate are shown in Table 3 below.

division Staphylococcus P. aeruginosa Escherichia coli Candida
Albikans Burg Helderia Sepassia Black mold Example 1 99.9% 99.3% 99.9% 95.7% 92.4% 99.9% Example 2 99.9% 99.8% 99.9% 97.8% 90.3% 99.9% Example 3 90.6% 91.4% 90.4% 90.1% 91.4% 90.3% Example 4 91.5% 90.7% 91.2% 90.2% 90.1% 90.4% Comparative Example 1 74.7% 79.1% 72.9% 69.3% 0% 66.7% Comparative Example 2 73.5% 81.6% 80.8% 70.0% 0% 65.9% Comparative Example 3 79.1% 82.4% 85.4% 80.1% 0% 65.3% Comparative Example 4 78.9% 80.2% 87.1% 84.4% 0% 66.4%

As shown in Table 3, it can be seen that Comparative Examples 1 to 4 exhibited a significantly lower mortality than Examples 1 to 4 in antibacterial and antifungal activity.

In addition, it can be seen that Examples 1 to 4 have high antiseptic effect against bacteria and fungi. In addition, the bacteria controlling effect of Burkholderia sp. .

The content of cetylpyridinium chloride chloride contained in Comparative Examples 1 to 4 was higher than that of troponone contained in Examples 1 to 4, but the amount of cetylpyridinium chloride contained in Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and black fungus have low antibacterial and antifungal effect.

Experimental Example 4: Measurement of bubble generation amount

The wet tissue liquid containing the wet tissue composition according to Examples 1 to 4 and Comparative Examples 1 to 4 was prepared and the present experiment was conducted.

The wet tissue solution was prepared by diluting 0.4% by weight of the wet tissue compositions of Examples 1 to 4 and Comparative Examples 1 to 4 with purified water to prepare a wet tissue solution.

The wet tissue solution containing each of the prepared preservative compositions was mixed in a mixer at 500 rpm for 1 minute and the amount of the remaining foam was measured after 5 minutes.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Bubble height (cm) 0.1 0.1 1.0 1.6 6.5 5.2 3.5 4.3 Foaming time (minutes) One 0.5 3 8 30 25 20 25

As shown in Table 4, it can be seen that the bubble generation amount of Examples 1 to 4 is smaller than that of Comparative Examples 1 to 4.

Also, it can be seen from Examples 1 to 4 that bubbles are not generated as much as possible in the process of manufacturing the wet tissue.

Experimental Example 5: Measurement of the number of occurrences of pop-up phenomenon

The wet tissue liquid containing the wet tissue composition according to Examples 1 to 4 and Comparative Examples 1 to 4 was prepared and the present experiment was conducted.

The wet tissue solution was prepared by diluting 0.4% by weight of the wet tissue compositions of Examples 1 to 4 and Comparative Examples 1 to 4 with purified water to prepare a wet tissue solution.

Each of the wet tissues prepared as described above was impregnated with 100 pieces of fabric, and each wet tissue product was manufactured with the same. Then, the wet tissue was pulled out at the same speed as the same force. At the same time, , That is, the number of pop-up phenomena was measured. The experiment was repeated 10 times and the average value was recorded.

division Example 1 Example 2 Example 3 Implementation 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 pop-up
Number of times - - One 3 60 40 20 48

As shown in Table 5, it can be seen that the pop-up phenomenon is significantly reduced in Examples 1 to 4 compared to Comparative Examples 1 to 4.

As a result of Table 5, it can be confirmed that the composition is suitable as a preservative composition for wet tissues of Examples 1 to 4 prepared according to the present invention.

Experimental Example 6: Diffusion Force Measurement

The wet tissue liquid containing the wet tissue composition according to Examples 1 to 4 and Comparative Examples 1 to 4 was prepared and the present experiment was conducted.

The wet tissue solution was prepared by diluting 0.4% by weight of the wet tissue compositions of Examples 1 to 4 and Comparative Examples 1 to 4 with purified water to prepare a wet tissue solution.

Each of the wet wipes thus prepared was dropped into the center of a stack of 30 sheets of nonwoven fabric (15 cm x 15 cm) using a syringe and left to stand for 5 minutes. The degree of diffusion was measured, and the spread The diameter and the diffusion diameter of the bottom field were measured and compared. The experiment was repeated 10 times and the average value was recorded.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Top
Diameter (cm) 12.0 11.4 10.1 10.0 6.3 6.5 5.3 5.4 Bottom
Diameter (cm) 9.7 9.2 9.0 8.8 3.6 4.0 2.3 2.1

As shown in Table 6, it can be seen that the diffusing power of Examples 1 to 4 is higher than that of Comparative Examples 1 to 4.

Experimental Example 7: Antiseptic composition safety

Experiments to measure the safety of the wet tissue compositions according to Examples 1 to 4 and Comparative Examples 1 to 4 were conducted.

The wet tissue composition containing each of the preservative compositions prepared above was allowed to stand for 30 days in an incubator at 60 캜 to confirm the phase separation and physical properties of the composition.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Whether phase separation Not phase separated Not phase separated Not phase separated Not phase separated Phase separation Phase separation Phase separation Phase separation

As shown in Table 7, it can be seen that Examples 1 to 4 have higher preservative composition safety than Comparative Examples 1 to 4.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, Of course.

Claims (3)

In a preservative composition comprising tropolone,
The wet tissue composition comprises: a) tropolone;
b) one or two or more of glycines, alkanediols, organic acids, hexamidine and salts thereof or quaternary ammonium; And
c) purified water;
A preservative composition comprising tropolone, which is characterized in that it has an antibacterial effect on Burkholderia sp.
The method according to claim 1,
Said wipe tissue composition comprising: a) from 0.001 to 20% by weight of tropolone;
b) 0.0001 to 20% by weight of one or more of glycines, alkanediols, organic acids, hexamidine and its salts or quaternary ammonium;
c) from 60 to 99.99% by weight of purified water.
A wet tissue comprising a preservative composition produced by any one of claims 1 to 2.