KR20200085175A - Cosmetic composition and preparation method of the same - Google Patents

Abstract

The present invention relates to a cosmetic composition, and more specifically, to a cosmetic composition which is hypoallergenic to the skin and has broad antibacterial activity by including hydroxyacetophenone (4′-Hydroxyacetophenone) and cetylpyridinium chloride, and a preparation method thereof.

Description

Cosmetic composition and method for manufacturing the same{COSMETIC COMPOSITION AND PREPARATION METHOD OF THE SAME}

The present invention relates to a cosmetic composition having a wide range of antibacterial and antiseptic activity and a method for manufacturing the same.

In general, it kills microorganisms such as bacteria, fungi and yeast belonging to the fungi that cause decay or deterioration, or inhibits their growth.It is a food to prevent spoilage due to microbial growth or unwanted chemical changes and to preserve it for a certain period of time. Preservatives are used in various products such as cosmetics and medicines.

In general, most chemically synthesized artificial substances are used as materials used as a preservative, for example, chloromethylisothiazolinone (CMIT), 3-iodo-2-propynylbutyl carbamate (3- lodo-2-propynylbutylcarbamate (IPBC), Benzalkonium Chloride (BKC), polyhexamethylene guanidine (PHMG), polyhexamethylene biguanide (PHMB), parabens, imidazolidinyl urea, diazolidinyl urea, alcohol (Alchol) and others are used as antibacterial and antiseptic agents.

However, the paraben (Paraben) preservatives have problems such as skin allergy and resistant bacteria. In addition, guadinine-based materials such as PHMG, PHMB and PGH have many problems, such as risk issues as a causative agent of acute lung injury symptoms caused by disinfectants for humidifiers.

As described above, the risk of such artificial preservatives has emerged, and recently, the cosmetics and food industry is researched to replace various chemicals used as preservatives as well as parabens as substances with minimal human toxicity. have. However, due to the high price of natural materials and the lack of processing technology for natural materials, natural materials cannot be used as preservatives. In addition, in the case of natural active materials, most of them are not commercialized due to poor color, stability, and antimicrobial properties, and problems in formulations and reproducibility.

Therefore, it is required to develop an antibacterial and antiseptic substance that is not only harmless and persistent to the human body that is capable of substituting the previously used antibacterial and antiseptic substances, and is harmless to the human body or has very low toxicity, and is harmless even when used for a long time. have.

Andrea Counti et al., Contact Dermatitis, 1997, 37; 35-36

The present invention is to solve the problems of the preservatives currently being used as described above, it is harmless to the human body and has no irritation to the skin, and suggests a cosmetic composition having improved antibacterial and antiseptic power against bacteria and fungi and a method for manufacturing the same The purpose.

To achieve the above object, the cosmetic composition of the present invention is 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight, cetylpyridinium chloride (cetylpyridinium chloride) 0.001 to 30% by weight, and the total composition It may contain a residual amount of water so that the total weight is 100% by weight.

Another cosmetic composition of the present invention is 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight, cetylpyridinium chloride (cetylpyridinium chloride) 0.001 to 30% by weight, sodium dehydroacetate (sodium dehydroacetate), 0.01 to 0.04% by weight of any one compound selected from sodium benzoate, caprylhydroxamic acid and alkanediol, and a balance of 100% by weight of the total composition It may contain water.

In the cosmetic composition, when the content of the 4'-hydroxyacetophenone is 0.1% by weight, the cetylpyridinium chloride is preferably included in an amount of more than 0.001% by weight.

In addition, when the content of the 4'-hydroxyacetophenone in the cosmetic composition is 0.4% by weight or less, it is preferable that the cetylpyridinium chloride is contained in an amount of more than 0.04% by weight and 30% by weight or less.

As the alkanediol, any one or more selected from octandiol, hexanediol and propandiol may be used, and hexanediol may be used.

In the cosmetic composition, chlorphenesin (chlorphenesin) and one or more compounds selected from tropolone (tropolone) may further include 1 to 40% by weight based on the total weight of the composition.

The cosmetic composition is Escherichia coli coli ), Staphylococcus aureus ( Staphyloccoccus aureus), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Candida albicans (Candida albicans ) and Aspergillus niger .

The cosmetic composition is a cosmetic composition, characterized in that the pH is 3.0 to 5.0.

The formulation of the cosmetic composition may be any one or more selected from aqueous solutions, emulsions, dispersions, suspensions, and useful solutions, and is not necessarily limited thereto, and may be used in various cosmetic formulations.

In addition, in order to achieve the above object, the method of preparing the cosmetic composition of the present invention is 4'-hydroxyacetophenone (4'-hydroxyacetophenone) and cetylpyridinium chloride (cetylpyridinium chloride) in water and stirred to prepare the cosmetic composition It may include the step of manufacturing.

In another method of preparing the cosmetic composition of the present invention, 4'-hydroxyacetophenone, 4,-hydroxyacetophenone, cetylpyridinium chloride and sodium dehydroacetate, sodium benzoate ( Sodium benzoate), capryl hydroxamic acid (caprylhydroxamic acid) and alkanediol (alkanediol) may include a step of preparing a cosmetic composition by adding and stirring any one compound selected from.

The step of preparing the cosmetic composition, 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight, cetylpyridinium chloride (cetylpyridinium chloride) 0.001 to 30% by weight, sodium dehydroacetate (sodium dehydroacetate) , 0.01 to 0.04% by weight of any one compound selected from sodium benzoate, caprylhydroxamic acid, and alkanediol, and a residual amount such that the total weight of the total composition is 100% by weight The mixture of water can be stirred to prepare a cosmetic composition.

In the step of preparing the cosmetic composition, if the content of the 4'-hydroxyacetophenone is 0.1% by weight, the cetylpyridinium chloride is preferably included in an amount of more than 0.001% by weight.

In addition, in the cosmetic composition, when the content of the 4'-hydroxyacetophenone is 0.4% by weight or less, the cetylpyridinium chloride is preferably included in an amount of more than 0.04% by weight and 30% by weight or less.

In the step of preparing the cosmetic composition, any one or more compounds selected from chlorphenesin and tropolone may be added to the cosmetic composition in an amount of 1 to 40% by weight based on the total weight of the composition.

After the step of preparing the cosmetic composition, the method may further include adjusting a pH concentration of the cosmetic composition to be 3.0 to 5.0 by adding a pH adjusting agent to the prepared cosmetic composition.

As the pH adjusting agent, those well known in the art may be used as a pH adjusting agent for cosmetics, and for example, an acid such as hydrochloric acid (HCl) may be used as the pH adjusting agent, but is not limited thereto.

In the cosmetic composition of the present invention, sodium dehydroacetate, sodium benzoate, caprylhydroxamic acid, and alkanediol organic acid are presented, but are not limited thereto. Organic acids, etc., which exhibit antibacterial effects known to those skilled in the art can be used.

The cosmetic composition of the present invention has a wide range of antibacterial or antiseptic activity, including fungi and bacteria, but has low skin irritation and harmlessness to the human body, and thus has high stability, and thus can be usefully used in various cosmetic products as an antibacterial and antiseptic.

Hereinafter, the present invention will be described in more detail through Examples, but these Examples are only examples of cosmetic compositions for the present invention, and the scope of the present invention is not limited to these Examples, and does not depart from the technical spirit of the present invention. It will be apparent to those skilled in the art that various modifications, variations, and changes can be made within the scope of the present invention, and it is obvious that portions easily changeable by those skilled in the art are included in the scope of the present invention.

4'-hydroxyacetophenone (4'-hydroxyacetophenone), cetylpyridinium chloride and sodium dehydroacetate, sodium benzoate, as shown in Tables 1 to 4 below, The components and contents of any one compound selected from caprylhydroxamic acid and 1,2-hexanediol (hexandiol) were added to purified water and stirred with a stirrer to completely dissolve to prepare a cosmetic composition of the example.

In Tables 1 to 4, "4'-HDP" is 4'-hydroxyacetophenone, "CPC" is cetylpyridinium chloride, and "SDA" is sodium dehydro. Acetate (sodium dehydroacetate), “CHA” is caprylhydroxamic acid, “SBA” is sodium benzoate, and “HXD” is 1,2-hexanediol (1,2- hexandiol).

Examples 1-1 to 1-75 shown in Table 1 are 4'-hydroxyacetophenone, cetylpyridinium chloride, and organic acid as sodium dehydroacetate. It is a cosmetic composition prepared by putting the ingredients and contents as shown in Table 1 below.

division 4'-HDP CPC SDA Purified water weight% Example 1-1 30 30 0.04 Remaining amount (to 100) Example 1-2 30 30 0.02 Remaining amount (to 100) Example 1-3 30 30 0.01 Remaining amount (to 100) Example 1-4 30 0.5 0.04 Remaining amount (to 100) Example 1-5 30 0.5 0.02 Remaining amount (to 100) Example 1-6 30 0.5 0.01 Remaining amount (to 100) Example 1-7 30 0.1 0.04 Remaining amount (to 100) Example 1-8 30 0.1 0.02 Remaining amount (to 100) Example 1-9 30 0.1 0.01 Remaining amount (to 100) Example 1-10 30 0.04 0.04 Remaining amount (to 100) Example 1-11 30 0.04 0.02 Remaining amount (to 100) Example 1-12 30 0.04 0.01 Remaining amount (to 100) Example 1-13 30 0.001 0.04 Remaining amount (to 100) Example 1-14 30 0.001 0.02 Remaining amount (to 100) Example 1-15 30 0.001 0.01 Remaining amount (to 100) Example 1-16 0.5 30 0.04 Remaining amount (to 100) Example 1-17 0.5 30 0.02 Remaining amount (to 100) Example 1-18 0.5 30 0.01 Remaining amount (to 100) Example 1-19 0.5 0.5 0.04 Remaining amount (to 100) Example 1-20 0.5 0.5 0.02 Remaining amount (to 100) Example 1-21 0.5 0.5 0.01 Remaining amount (to 100) Example 1-22 0.5 0.1 0.04 Remaining amount (to 100) Example 1-23 0.5 0.1 0.02 Remaining amount (to 100) Example 1-24 0.5 0.1 0.01 Remaining amount (to 100) Example 1-25 0.5 0.04 0.04 Remaining amount (to 100) Example 1-26 0.5 0.04 0.02 Remaining amount (to 100) Example 1-27 0.5 0.04 0.01 Remaining amount (to 100) Example 1-28 0.5 0.001 0.04 Remaining amount (to 100) Example 1-29 0.5 0.001 0.02 Remaining amount (to 100) Example 1-30 0.5 0.001 0.01 Remaining amount (to 100) Example 1-31 0.1 30 0.04 Remaining amount (to 100) Example 1-32 0.1 30 0.02 Remaining amount (to 100) Example 1-33 0.1 30 0.01 Remaining amount (to 100) Example 1-34 0.1 0.5 0.04 Remaining amount (to 100) Example 1-35 0.1 0.5 0.02 Remaining amount (to 100) Example 1-36 0.1 0.5 0.01 Remaining amount (to 100) Example 1-37 0.1 0.1 0.04 Remaining amount (to 100) Example 1-38 0.1 0.1 0.02 Remaining amount (to 100) Example 1-39 0.1 0.1 0.01 Remaining amount (to 100) Example 1-40 0.1 0.04 0.04 Remaining amount (to 100) Example 1-41 0.1 0.04 0.02 Remaining amount (to 100) Example 1-42 0.1 0.04 0.01 Remaining amount (to 100) Example 1-43 0.1 0.001 0.04 Remaining amount (to 100) Example 1-44 0.1 0.001 0.02 Remaining amount (to 100) Example 1-45 0.1 0.001 0.01 Remaining amount (to 100) Example 1-46 0.04 30 0.04 Remaining amount (to 100) Example 1-47 0.04 30 0.02 Remaining amount (to 100) Example 1-48 0.04 30 0.01 Remaining amount (to 100) Example 1-49 0.04 0.5 0.04 Remaining amount (to 100) Example 1-50 0.04 0.5 0.02 Remaining amount (to 100) Example 1-51 0.04 0.5 0.01 Remaining amount (to 100) Example 1-52 0.04 0.1 0.04 Remaining amount (to 100) Example 1-53 0.04 0.1 0.02 Remaining amount (to 100) Example 1-54 0.04 0.1 0.01 Remaining amount (to 100) Example 1-55 0.04 0.04 0.04 Remaining amount (to 100) Example 1-56 0.04 0.04 0.02 Remaining amount (to 100) Example 1-57 0.04 0.04 0.01 Remaining amount (to 100) Example 1-58 0.04 0.001 0.04 Remaining amount (to 100) Example 1-59 0.04 0.001 0.02 Remaining amount (to 100) Example 1-60 0.04 0.001 0.01 Remaining amount (to 100) Example 1-61 0.001 30 0.04 Remaining amount (to 100) Example 1-62 0.001 30 0.02 Remaining amount (to 100) Example 1-63 0.001 30 0.01 Remaining amount (to 100) Example 1-64 0.001 0.5 0.04 Remaining amount (to 100) Example 1-65 0.001 0.5 0.02 Remaining amount (to 100) Example 1-66 0.001 0.5 0.01 Remaining amount (to 100) Example 1-67 0.001 0.1 0.04 Remaining amount (to 100) Example 1-68 0.001 0.1 0.02 Remaining amount (to 100) Example 1-69 0.001 0.1 0.01 Remaining amount (to 100) Example 1-70 0.001 0.04 0.04 Remaining amount (to 100) Example 1-71 0.001 0.04 0.02 Remaining amount (to 100) Example 1-72 0.001 0.04 0.01 Remaining amount (to 100) Example 1-73 0.001 0.001 0.04 Remaining amount (to 100) Example 1-74 0.001 0.001 0.02 Remaining amount (to 100) Example 1-75 0.001 0.001 0.01 Remaining amount (to 100)

Examples 2-1 to 2-75 shown in Table 2 are components of 4'-hydroxyacetophenone, cetylpyridinium chloride, and caprylhydroxamic acid And it is a cosmetic composition prepared by putting the content as shown in Table 2.

division 4'-HDP CPC CHA Purified water weight% Example 2-1 30 30 0.04 Remaining amount (to 100) Example 2-2 30 30 0.02 Remaining amount (to 100) Example 2-3 30 30 0.01 Remaining amount (to 100) Example 2-4 30 0.5 0.04 Remaining amount (to 100) Example 2-5 30 0.5 0.02 Remaining amount (to 100) Example 2-6 30 0.5 0.01 Remaining amount (to 100) Example 2-7 30 0.1 0.04 Remaining amount (to 100) Example 2-8 30 0.1 0.02 Remaining amount (to 100) Example 2-9 30 0.1 0.01 Remaining amount (to 100) Example 2-10 30 0.04 0.04 Remaining amount (to 100) Example 2-11 30 0.04 0.02 Remaining amount (to 100) Example 2-12 30 0.04 0.01 Remaining amount (to 100) Example 2-13 30 0.001 0.04 Remaining amount (to 100) Example 2-14 30 0.001 0.02 Remaining amount (to 100) Example 2-15 30 0.001 0.01 Remaining amount (to 100) Example 2-16 0.5 30 0.04 Remaining amount (to 100) Example 2-17 0.5 30 0.02 Remaining amount (to 100) Example 2-18 0.5 30 0.01 Remaining amount (to 100) Example 2-19 0.5 0.5 0.04 Remaining amount (to 100) Example 2-20 0.5 0.5 0.02 Remaining amount (to 100) Example 2-21 0.5 0.5 0.01 Remaining amount (to 100) Example 2-22 0.5 0.1 0.04 Remaining amount (to 100) Example 2-23 0.5 0.1 0.02 Remaining amount (to 100) Example 2-24 0.5 0.1 0.01 Remaining amount (to 100) Example 2-25 0.5 0.04 0.04 Remaining amount (to 100) Example 2-26 0.5 0.04 0.02 Remaining amount (to 100) Example 2-27 0.5 0.04 0.01 Remaining amount (to 100) Example 2-28 0.5 0.001 0.04 Remaining amount (to 100) Example 2-29 0.5 0.001 0.02 Remaining amount (to 100) Example 2-30 0.5 0.001 0.01 Remaining amount (to 100) Example 2-31 0.1 30 0.04 Remaining amount (to 100) Example 2-32 0.1 30 0.02 Remaining amount (to 100) Example 2-33 0.1 30 0.01 Remaining amount (to 100) Example 2-34 0.1 0.5 0.04 Remaining amount (to 100) Example 2-35 0.1 0.5 0.02 Remaining amount (to 100) Example 2-36 0.1 0.5 0.01 Remaining amount (to 100) Example 2-37 0.1 0.1 0.04 Remaining amount (to 100) Example 2-38 0.1 0.1 0.02 Remaining amount (to 100) Example 2-39 0.1 0.1 0.01 Remaining amount (to 100) Example 2-40 0.1 0.04 0.04 Remaining amount (to 100) Example 2-41 0.1 0.04 0.02 Remaining amount (to 100) Example 2-42 0.1 0.04 0.01 Remaining amount (to 100) Example 2-43 0.1 0.001 0.04 Remaining amount (to 100) Example 2-44 0.1 0.001 0.02 Remaining amount (to 100) Example 2-45 0.1 0.001 0.01 Remaining amount (to 100) Example 2-46 0.04 30 0.04 Remaining amount (to 100) Example 2-47 0.04 30 0.02 Remaining amount (to 100) Example 2-48 0.04 30 0.01 Remaining amount (to 100) Example 2-49 0.04 0.5 0.04 Remaining amount (to 100) Example 2-50 0.04 0.5 0.02 Remaining amount (to 100) Example 2-51 0.04 0.5 0.01 Remaining amount (to 100) Example 2-52 0.04 0.1 0.04 Remaining amount (to 100) Example 2-53 0.04 0.1 0.02 Remaining amount (to 100) Example 2-54 0.04 0.1 0.01 Remaining amount (to 100) Example 2-55 0.04 0.04 0.04 Remaining amount (to 100) Example 2-56 0.04 0.04 0.02 Remaining amount (to 100) Example 2-57 0.04 0.04 0.01 Remaining amount (to 100) Example 2-58 0.04 0.001 0.04 Remaining amount (to 100) Example 2-59 0.04 0.001 0.02 Remaining amount (to 100) Example 2-60 0.04 0.001 0.01 Remaining amount (to 100) Example 2-61 0.001 30 0.04 Remaining amount (to 100) Example 2-62 0.001 30 0.02 Remaining amount (to 100) Example 2-63 0.001 30 0.01 Remaining amount (to 100) Example 2-64 0.001 0.5 0.04 Remaining amount (to 100) Example 2-65 0.001 0.5 0.02 Remaining amount (to 100) Example 2-66 0.001 0.5 0.01 Remaining amount (to 100) Example 2-67 0.001 0.1 0.04 Remaining amount (to 100) Example 2-68 0.001 0.1 0.02 Remaining amount (to 100) Example 2-69 0.001 0.1 0.01 Remaining amount (to 100) Example 2-70 0.001 0.04 0.04 Remaining amount (to 100) Example 2-71 0.001 0.04 0.02 Remaining amount (to 100) Example 2-72 0.001 0.04 0.01 Remaining amount (to 100) Example 2-73 0.001 0.001 0.04 Remaining amount (to 100) Example 2-74 0.001 0.001 0.02 Remaining amount (to 100) Example 2-75 0.001 0.001 0.01 Remaining amount (to 100)

Examples 3-1 to 3-75 shown in Table 3 are components of 4'-hydroxyacetophenone, cetylpyridinium chloride and organic acid as sodium benzoate And it is a cosmetic composition prepared by putting the content as shown in Table 3.

division 4'-HDP CPC SBA Purified water weight% Example 3-1 30 30 0.04 Remaining amount (to 100) Example 3-2 30 30 0.02 Remaining amount (to 100) Example 3-3 30 30 0.01 Remaining amount (to 100) Example 3-4 30 0.5 0.04 Remaining amount (to 100) Example 3-5 30 0.5 0.02 Remaining amount (to 100) Example 3-6 30 0.5 0.01 Remaining amount (to 100) Example 3-7 30 0.1 0.04 Remaining amount (to 100) Example 3-8 30 0.1 0.02 Remaining amount (to 100) Example 3-9 30 0.1 0.01 Remaining amount (to 100) Example 3-10 30 0.04 0.04 Remaining amount (to 100) Example 3-11 30 0.04 0.02 Remaining amount (to 100) Example 3-12 30 0.04 0.01 Remaining amount (to 100) Example 3-13 30 0.001 0.04 Remaining amount (to 100) Example 3-14 30 0.001 0.02 Remaining amount (to 100) Example 3-15 30 0.001 0.01 Remaining amount (to 100) Example 3-16 0.5 30 0.04 Remaining amount (to 100) Example 3-17 0.5 30 0.02 Remaining amount (to 100) Example 3-18 0.5 30 0.01 Remaining amount (to 100) Example 3-19 0.5 0.5 0.04 Remaining amount (to 100) Example 3-20 0.5 0.5 0.02 Remaining amount (to 100) Example 3-21 0.5 0.5 0.01 Remaining amount (to 100) Example 3-22 0.5 0.1 0.04 Remaining amount (to 100) Example 3-23 0.5 0.1 0.02 Remaining amount (to 100) Example 3-24 0.5 0.1 0.01 Remaining amount (to 100) Example 3-25 0.5 0.04 0.04 Remaining amount (to 100) Example 3-26 0.5 0.04 0.02 Remaining amount (to 100) Example 3-27 0.5 0.04 0.01 Remaining amount (to 100) Example 3-28 0.5 0.001 0.04 Remaining amount (to 100) Example 3-29 0.5 0.001 0.02 Remaining amount (to 100) Example 3-30 0.5 0.001 0.01 Remaining amount (to 100) Example 3-31 0.1 30 0.04 Remaining amount (to 100) Example 3-32 0.1 30 0.02 Remaining amount (to 100) Example 3-33 0.1 30 0.01 Remaining amount (to 100) Example 3-34 0.1 0.5 0.04 Remaining amount (to 100) Example 3-35 0.1 0.5 0.02 Remaining amount (to 100) Example 3-36 0.1 0.5 0.01 Remaining amount (to 100) Example 3-37 0.1 0.1 0.04 Remaining amount (to 100) Example 3-38 0.1 0.1 0.02 Remaining amount (to 100) Example 3-39 0.1 0.1 0.01 Remaining amount (to 100) Example 3-40 0.1 0.04 0.04 Remaining amount (to 100) Example 3-41 0.1 0.04 0.02 Remaining amount (to 100) Example 3-42 0.1 0.04 0.01 Remaining amount (to 100) Example 3-43 0.1 0.001 0.04 Remaining amount (to 100) Example 3-44 0.1 0.001 0.02 Remaining amount (to 100) Example 3-45 0.1 0.001 0.01 Remaining amount (to 100) Example 3-46 0.04 30 0.04 Remaining amount (to 100) Example 3-47 0.04 30 0.02 Remaining amount (to 100) Example 3-48 0.04 30 0.01 Remaining amount (to 100) Example 3-49 0.04 0.5 0.04 Remaining amount (to 100) Example 3-50 0.04 0.5 0.02 Remaining amount (to 100) Example 3-51 0.04 0.5 0.01 Remaining amount (to 100) Example 3-52 0.04 0.1 0.04 Remaining amount (to 100) Example 3-53 0.04 0.1 0.02 Remaining amount (to 100) Example 3-54 0.04 0.1 0.01 Remaining amount (to 100) Example 3-55 0.04 0.04 0.04 Remaining amount (to 100) Example 3-56 0.04 0.04 0.02 Remaining amount (to 100) Example 3-57 0.04 0.04 0.01 Remaining amount (to 100) Example 3-58 0.04 0.001 0.04 Remaining amount (to 100) Example 3-59 0.04 0.001 0.02 Remaining amount (to 100) Example 3-60 0.04 0.001 0.01 Remaining amount (to 100) Example 3-61 0.001 30 0.04 Remaining amount (to 100) Example 3-62 0.001 30 0.02 Remaining amount (to 100) Example 3-63 0.001 30 0.01 Remaining amount (to 100) Example 3-64 0.001 0.5 0.04 Remaining amount (to 100) Example 3-65 0.001 0.5 0.02 Remaining amount (to 100) Example 3-66 0.001 0.5 0.01 Remaining amount (to 100) Example 3-67 0.001 0.1 0.04 Remaining amount (to 100) Example 3-68 0.001 0.1 0.02 Remaining amount (to 100) Example 3-69 0.001 0.1 0.01 Remaining amount (to 100) Example 3-70 0.001 0.04 0.04 Remaining amount (to 100) Example 3-71 0.001 0.04 0.02 Remaining amount (to 100) Example 3-72 0.001 0.04 0.01 Remaining amount (to 100) Example 3-73 0.001 0.001 0.04 Remaining amount (to 100) Example 3-74 0.001 0.001 0.02 Remaining amount (to 100) Example 3-75 0.001 0.001 0.01 Remaining amount (to 100)

Examples 4-1 to Examples 4-75 shown in Table 4 are 4'-hydroxyacetophenone, cetylpyridinium chloride and 1,2-hexanediol (1,2- hexandiol) is a cosmetic composition prepared by putting the ingredients and contents as shown in Table 4 below.

division 4'-HDP CPC HXD Purified water weight% Example 4-1 30 30 0.04 Remaining amount (to 100) Example 4-2 30 30 0.02 Remaining amount (to 100) Example 4-3 30 30 0.01 Remaining amount (to 100) Example 4-4 30 0.5 0.04 Remaining amount (to 100) Example 4-5 30 0.5 0.02 Remaining amount (to 100) Example 4-6 30 0.5 0.01 Remaining amount (to 100) Example 4-7 30 0.1 0.04 Remaining amount (to 100) Example 4-8 30 0.1 0.02 Remaining amount (to 100) Example 4-9 30 0.1 0.01 Remaining amount (to 100) Example 4-10 30 0.04 0.04 Remaining amount (to 100) Example 4-11 30 0.04 0.02 Remaining amount (to 100) Example 4-12 30 0.04 0.01 Remaining amount (to 100) Example 4-13 30 0.001 0.04 Remaining amount (to 100) Example 4-14 30 0.001 0.02 Remaining amount (to 100) Example 4-15 30 0.001 0.01 Remaining amount (to 100) Example 4-16 0.5 30 0.04 Remaining amount (to 100) Example 4-17 0.5 30 0.02 Remaining amount (to 100) Example 4-18 0.5 30 0.01 Remaining amount (to 100) Example 4-19 0.5 0.5 0.04 Remaining amount (to 100) Example 4-20 0.5 0.5 0.02 Remaining amount (to 100) Example 4-21 0.5 0.5 0.01 Remaining amount (to 100) Example 4-22 0.5 0.1 0.04 Remaining amount (to 100) Example 4-23 0.5 0.1 0.02 Remaining amount (to 100) Example 4-24 0.5 0.1 0.01 Remaining amount (to 100) Example 4-25 0.5 0.04 0.04 Remaining amount (to 100) Example 4-26 0.5 0.04 0.02 Remaining amount (to 100) Example 4-27 0.5 0.04 0.01 Remaining amount (to 100) Example 4-28 0.5 0.001 0.04 Remaining amount (to 100) Example 4-29 0.5 0.001 0.02 Remaining amount (to 100) Example 4-30 0.5 0.001 0.01 Remaining amount (to 100) Example 4-31 0.1 30 0.04 Remaining amount (to 100) Example 4-32 0.1 30 0.02 Remaining amount (to 100) Example 4-33 0.1 30 0.01 Remaining amount (to 100) Example 4-34 0.1 0.5 0.04 Remaining amount (to 100) Example 4-35 0.1 0.5 0.02 Remaining amount (to 100) Example 4-36 0.1 0.5 0.01 Remaining amount (to 100) Example 4-37 0.1 0.1 0.04 Remaining amount (to 100) Example 4-38 0.1 0.1 0.02 Remaining amount (to 100) Example 4-39 0.1 0.1 0.01 Remaining amount (to 100) Example 4-40 0.1 0.04 0.04 Remaining amount (to 100) Example 4-41 0.1 0.04 0.02 Remaining amount (to 100) Example 4-42 0.1 0.04 0.01 Remaining amount (to 100) Example 4-43 0.1 0.001 0.04 Remaining amount (to 100) Example 4-44 0.1 0.001 0.02 Remaining amount (to 100) Example 4-45 0.1 0.001 0.01 Remaining amount (to 100) Example 4-46 0.04 30 0.04 Remaining amount (to 100) Example 4-47 0.04 30 0.02 Remaining amount (to 100) Example 4-48 0.04 30 0.01 Remaining amount (to 100) Example 4-49 0.04 0.5 0.04 Remaining amount (to 100) Example 4-50 0.04 0.5 0.02 Remaining amount (to 100) Example 4-51 0.04 0.5 0.01 Remaining amount (to 100) Example 4-52 0.04 0.1 0.04 Remaining amount (to 100) Example 4-53 0.04 0.1 0.02 Remaining amount (to 100) Example 4-54 0.04 0.1 0.01 Remaining amount (to 100) Example 4-55 0.04 0.04 0.04 Remaining amount (to 100) Example 4-56 0.04 0.04 0.02 Remaining amount (to 100) Example 4-57 0.04 0.04 0.01 Remaining amount (to 100) Example 4-58 0.04 0.001 0.04 Remaining amount (to 100) Example 4-59 0.04 0.001 0.02 Remaining amount (to 100) Example 4-60 0.04 0.001 0.01 Remaining amount (to 100) Example 4-61 0.001 30 0.04 Remaining amount (to 100) Example 4-62 0.001 30 0.02 Remaining amount (to 100) Example 4-63 0.001 30 0.01 Remaining amount (to 100) Example 4-64 0.001 0.5 0.04 Remaining amount (to 100) Example 4-65 0.001 0.5 0.02 Remaining amount (to 100) Example 4-66 0.001 0.5 0.01 Remaining amount (to 100) Example 4-67 0.001 0.1 0.04 Remaining amount (to 100) Example 4-68 0.001 0.1 0.02 Remaining amount (to 100) Example 4-69 0.001 0.1 0.01 Remaining amount (to 100) Example 4-70 0.001 0.04 0.04 Remaining amount (to 100) Example 4-71 0.001 0.04 0.02 Remaining amount (to 100) Example 4-72 0.001 0.04 0.01 Remaining amount (to 100) Example 4-73 0.001 0.001 0.04 Remaining amount (to 100) Example 4-74 0.001 0.001 0.02 Remaining amount (to 100) Example 4-75 0.001 0.001 0.01 Remaining amount (to 100)

The antibacterial activity of the cosmetic composition prepared in the above Example was confirmed, and the results are shown in Tables 5 to 8 below.

Specifically, the antibacterial activity experiment of the cosmetic composition of the present invention was performed according to the U. S. Pharmacopoeia standard, and tested by a plate culture method to confirm the reduction and killing of bacteria.

The bacteria and fungi used for antibacterial activity were pre-sold by the Korea Research Institute of Bioscience and Biotechnology (KCTC) and the bacteria were Escherichia coli ; Strain No. 2571), Staphylococcus aureus (Staphylococcus aureus; Strain No. 3881), Pseudomonas aeruginosa (Pseudomonas aeruginosa ; Strain No. 2513) are using the mixed bacteria, fungi Candida albicans (Candida albicans; and strain number 7965), bacteria, fungus Aspergillus and this (Aspergillus niger; strain No. 6089) antimicrobial activity using the fungus Was confirmed.

Each of the fungal cultures was inoculated into the cosmetic composition prepared in the above Example, and the bacteria were cultured on a TSA (Tryptic Soy Agar) plate exclusion, and the fungus Candida albicans and the fungus Aspergillus niger were PDAs (Potato Dextrose Agar). ) After being applied to the plate medium, cultured in an incubator at a temperature of 30°C to 35°C, and then cultured.

'○' and'X' shown in Tables 5 to 8 below indicate whether or not the bacteria are killed. It is represented by, and if the mortality rate of the bacteria is less than 99.9%, it is represented by'X'. Here, the control group is inoculated with the bacterial culture solution in distilled water instead of the cosmetic composition of the embodiment.

[Calculation formula 1]

Killing rate of bacteria (%) = ((number of inoculation bacteria in the control group-number of remaining bacteria in the example) / number of inoculation bacteria in the control group) × 100

Composition Germ Fungi mold Composition Germ Fungi mold Example 1-1 ○ ○ ○ Example 1-39 ○ ○ ○ Example 1-2 ○ ○ ○ Example 1-40 ○ ○ ○ Example 1-3 ○ ○ ○ Example 1-41 ○ ○ ○ Example 1-4 ○ ○ ○ Example 1-42 ○ ○ ○ Example 1-5 ○ ○ ○ Example 1-43 X X X Example 1-6 ○ ○ ○ Example 1-44 X X X Example 1-7 ○ ○ ○ Example 1-45 X X X Example 1-8 ○ ○ ○ Example 1-46 ○ ○ ○ Example 1-9 ○ ○ ○ Example 1-47 ○ ○ ○ Example 1-10 ○ ○ ○ Example 1-48 ○ ○ ○ Example 1-11 ○ ○ ○ Example 1-49 ○ ○ ○ Example 1-12 ○ ○ ○ Example 1-50 ○ ○ ○ Example 1-13 ○ ○ ○ Example 1-51 ○ ○ ○ Example 1-14 ○ ○ ○ Example 1-52 ○ ○ ○ Example 1-15 ○ ○ ○ Example 1-53 ○ ○ ○ Example 1-16 ○ ○ ○ Example 1-54 ○ ○ ○ Example 1-17 ○ ○ ○ Example 1-55 X X X Example 1-18 ○ ○ ○ Example 1-56 X X X Example 1-19 ○ ○ ○ Example 1-57 X X X Example 1-20 ○ ○ ○ Example 1-58 X X X Example 1-21 ○ ○ ○ Example 1-59 X X X Example 1-22 ○ ○ ○ Example 1-60 X X X Example 1-23 ○ ○ ○ Example 1-61 ○ ○ ○ Example 1-24 ○ ○ ○ Example 1-62 ○ ○ ○ Example 1-25 ○ ○ ○ Example 1-63 ○ ○ ○ Example 1-26 ○ ○ ○ Example 1-64 ○ ○ ○ Example 1-27 ○ ○ ○ Example 1-65 ○ ○ ○ Example 1-28 ○ ○ ○ Example 1-66 ○ ○ ○ Example 1-29 ○ ○ ○ Example 1-67 ○ ○ ○ Example 1-30 ○ ○ ○ Example 1-68 ○ ○ ○ Example 1-31 ○ ○ ○ Example 1-69 ○ ○ ○ Example 1-32 ○ ○ ○ Example 1-70 X X X Example 1-33 ○ ○ ○ Example 1-71 X X X Example 1-34 ○ ○ ○ Example 1-72 X X X Example 1-35 ○ ○ ○ Example 1-73 X X X Example 1-36 ○ ○ ○ Example 1-74 X X X Example 1-37 ○ ○ ○ Example 1-75 X X X Example 1-38 ○ ○ ○

As shown in Table 5, the content of 4'-hydroxyacetophenone in the cosmetic composition as in Examples 1-43 to 1-45 as a cosmetic composition containing sodium dehydroacetate as an organic acid is 0.1 wt. %, and when the content of cetylpyridinium chloride is 0.001% by weight, and 4'-hydroxyaceto as in Examples 1-55 to 1-60, Examples 1-70 to 1-75 When the content of phenone (4'-hydroxyacetophenone) is 0.04% by weight and 0.001% by weight, and when cetylpyridinium chloride is contained by 0.04% and 0.001% by weight, respectively, bacteria are present in both bacteria, fungi, and fungi. It can be seen that the anti-bacterial efficiency is not satisfied because the mortality rate of is less than 99.9%.

Composition Germ Fungi mold Composition Germ Fungi mold Example 2-1 ○ ○ ○ Example 2-39 ○ ○ ○ Example 2-2 ○ ○ ○ Example 2-40 ○ ○ ○ Example 2-3 ○ ○ ○ Example 2-41 ○ ○ ○ Example 2-4 ○ ○ ○ Example 2-42 ○ ○ ○ Example 2-5 ○ ○ ○ Example 2-43 X X X Example 2-6 ○ ○ ○ Example 2-44 X X X Example 2-7 ○ ○ ○ Example 2-45 X X X Example 2-8 ○ ○ ○ Example 2-46 ○ ○ ○ Example 2-9 ○ ○ ○ Example 2-47 ○ ○ ○ Example 2-10 ○ ○ ○ Example 2-48 ○ ○ ○ Example 2-11 ○ ○ ○ Example 2-49 ○ ○ ○ Example 2-12 ○ ○ ○ Example 2-50 ○ ○ ○ Example 2-13 ○ ○ ○ Example 2-51 ○ ○ ○ Example 2-14 ○ ○ ○ Example 2-52 ○ ○ ○ Example 2-15 ○ ○ ○ Example 2-53 ○ ○ ○ Example 2-16 ○ ○ ○ Example 2-54 ○ ○ ○ Example 2-17 ○ ○ ○ Example 2-55 X X X Example 2-18 ○ ○ ○ Example 2-56 X X X Example 2-19 ○ ○ ○ Example 2-57 X X X Example 2-20 ○ ○ ○ Example 2-58 X X X Example 2-21 ○ ○ ○ Example 2-59 X X X Example 2-22 ○ ○ ○ Example 2-60 X X X Example 2-23 ○ ○ ○ Example 2-61 ○ ○ ○ Example 2-24 ○ ○ ○ Example 2-62 ○ ○ ○ Example 2-25 ○ ○ ○ Example 2-63 ○ ○ ○ Example 2-26 ○ ○ ○ Example 2-64 ○ ○ ○ Example 2-27 ○ ○ ○ Example 2-65 ○ ○ ○ Example 2-28 ○ ○ ○ Example 2-66 ○ ○ ○ Example 2-29 ○ ○ ○ Example 2-67 ○ ○ ○ Example 2-30 ○ ○ ○ Example 2-68 ○ ○ ○ Example 2-31 ○ ○ ○ Example 2-69 ○ ○ ○ Example 2-32 ○ ○ ○ Example 2-70 X X X Example 2-33 ○ ○ ○ Example 2-71 X X X Example 2-34 ○ ○ ○ Example 2-72 X X X Example 2-35 ○ ○ ○ Example 2-73 X X X Example 2-36 ○ ○ ○ Example 2-74 X X X Example 2-37 ○ ○ ○ Example 2-75 X X X Example 2-38 ○ ○ ○

As shown in Table 6, the cosmetic composition containing caprylhydroxamic acid is 4%-hydroxyacetophenone in the cosmetic composition as in Example 2-43 to Example 2-45. 4'-hydroxyacetophenone as shown in Examples 2-55 to Example 2-60, Examples 2-70 to Examples 2-75, and the content of cetylpyridinium chloride as 0.001% by weight. When the content of (4'-hydroxyacetophenone) is 0.04% by weight and 0.001% by weight and cetylpyridinium chloride is contained by 0.04% and 0.001% by weight, respectively, bacteria, fungi and fungi It can be seen that the mortality rate is less than 99.9%, so that the antibacterial efficiency is not satisfied.

Composition Germ Fungi mold Composition Germ Fungi mold Example 3-1 ○ ○ ○ Example 3-39 ○ ○ ○ Example 3-2 ○ ○ ○ Example 3-40 ○ ○ ○ Example 3-3 ○ ○ ○ Example 3-41 ○ ○ ○ Example 3-4 ○ ○ ○ Example 3-42 ○ ○ ○ Example 3-5 ○ ○ ○ Example 3-43 X X X Example 3-6 ○ ○ ○ Example 3-44 X X X Example 3-7 ○ ○ ○ Example 3-45 X X X Example 3-8 ○ ○ ○ Example 3-46 ○ ○ ○ Example 3-9 ○ ○ ○ Example 3-47 ○ ○ ○ Example 3-10 ○ ○ ○ Example 3-48 ○ ○ ○ Example 3-11 ○ ○ ○ Example 3-49 ○ ○ ○ Example 3-12 ○ ○ ○ Example 3-50 ○ ○ ○ Example 3-13 ○ ○ ○ Example 3-51 ○ ○ ○ Example 3-14 ○ ○ ○ Example 3-52 ○ ○ ○ Example 3-15 ○ ○ ○ Example 3-53 ○ ○ ○ Example 3-16 ○ ○ ○ Example 3-54 ○ ○ ○ Example 3-17 ○ ○ ○ Example 3-55 X X X Example 3-18 ○ ○ ○ Example 3-56 X X X Example 3-19 ○ ○ ○ Example 3-57 X X X Example 3-20 ○ ○ ○ Example 3-58 X X X Example 3-21 ○ ○ ○ Example 3-59 X X X Example 3-22 ○ ○ ○ Example 3-60 X X X Example 3-23 ○ ○ ○ Example 3-61 ○ ○ ○ Example 3-24 ○ ○ ○ Example 3-62 ○ ○ ○ Example 3-25 ○ ○ ○ Example 3-63 ○ ○ ○ Example 3-26 ○ ○ ○ Example 3-64 ○ ○ ○ Example 3-27 ○ ○ ○ Example 3-65 ○ ○ ○ Example 3-28 ○ ○ ○ Example 3-66 ○ ○ ○ Example 3-29 ○ ○ ○ Example 3-67 ○ ○ ○ Example 3-30 ○ ○ ○ Example 3-68 ○ ○ ○ Example 3-31 ○ ○ ○ Example 3-69 ○ ○ ○ Example 3-32 ○ ○ ○ Example 3-70 X X X Example 3-33 ○ ○ ○ Example 3-71 X X X Example 3-34 ○ ○ ○ Example 3-72 X X X Example 3-35 ○ ○ ○ Example 3-73 X X X Example 3-36 ○ ○ ○ Example 3-74 X X X Example 3-37 ○ ○ ○ Example 3-75 X X X Example 3-38 ○ ○ ○

As shown in Table 7, the cosmetic composition containing sodium benzoate (sodium benzoate) as an organic acid, the content of 4'-hydroxyacetophenone in the cosmetic composition as in Examples 3-43 to Example 3-45 is 0.1% by weight 4'-hydroxyacetophenone as shown in Examples 3-55 to Example 3-60, Examples 3-70 to Example 3-75, and the content of cetylpyridinium chloride as 0.001% by weight. When the content of (4'-hydroxyacetophenone) is 0.04% by weight and 0.001% by weight and cetylpyridinium chloride is contained by 0.04% and 0.001% by weight, respectively, bacteria, fungi and fungi It can be seen that the anti-microbial efficiency is not satisfied because the mortality rate is less than 99.9%.

Composition Germ Fungi mold Composition Germ Fungi mold Example 4-1 ○ ○ ○ Example 4-39 ○ ○ ○ Example 4-2 ○ ○ ○ Example 4-40 ○ ○ ○ Example 4-3 ○ ○ ○ Example 4-41 ○ ○ ○ Example 4-4 ○ ○ ○ Example 4-42 ○ ○ ○ Example 4-5 ○ ○ ○ Example 4-43 X X X Example 4-6 ○ ○ ○ Example 4-44 X X X Example 4-7 ○ ○ ○ Example 4-45 X X X Example 4-8 ○ ○ ○ Example 4-46 ○ ○ ○ Example 4-9 ○ ○ ○ Example 4-47 ○ ○ ○ Example 4-10 ○ ○ ○ Example 4-48 ○ ○ ○ Example 4-11 ○ ○ ○ Example 4-49 ○ ○ ○ Example 4-12 ○ ○ ○ Example 4-50 ○ ○ ○ Example 4-13 ○ ○ ○ Example 4-51 ○ ○ ○ Example 4-14 ○ ○ ○ Example 4-52 ○ ○ ○ Example 4-15 ○ ○ ○ Example 4-53 ○ ○ ○ Example 4-16 ○ ○ ○ Example 4-54 ○ ○ ○ Example 4-17 ○ ○ ○ Example 4-55 X X X Example 4-18 ○ ○ ○ Example 4-56 X X X Example 4-19 ○ ○ ○ Example 4-57 X X X Example 4-20 ○ ○ ○ Example 4-58 X X X Example 4-21 ○ ○ ○ Example 4-59 X X X Example 4-22 ○ ○ ○ Example 4-60 X X X Example 4-23 ○ ○ ○ Example 4-61 ○ ○ ○ Example 4-24 ○ ○ ○ Example 4-62 ○ ○ ○ Example 4-25 ○ ○ ○ Example 4-63 ○ ○ ○ Example 4-26 ○ ○ ○ Example 4-64 ○ ○ ○ Example 4-27 ○ ○ ○ Example 4-65 ○ ○ ○ Example 4-28 ○ ○ ○ Example 4-66 ○ ○ ○ Example 4-29 ○ ○ ○ Example 4-67 ○ ○ ○ Example 4-30 ○ ○ ○ Example 4-68 ○ ○ ○ Example 4-31 ○ ○ ○ Example 4-69 ○ ○ ○ Example 4-32 ○ ○ ○ Example 4-70 X X X Example 4-33 ○ ○ ○ Example 4-71 X X X Example 4-34 ○ ○ ○ Example 4-72 X X X Example 4-35 ○ ○ ○ Example 4-73 X X X Example 4-36 ○ ○ ○ Example 4-74 X X X Example 4-37 ○ ○ ○ Example 4-75 X X X Example 4-38 ○ ○ ○

As shown in Table 8, the content of 4'-hydroxyacetophenone in the cosmetic composition as in Examples 4-43 to Example 4-45 as a cosmetic composition comprising 1,2-hexanediol (hexandiol) as an alkyndiol. 4'-hydro as in Examples 4-55 to Examples 4-60 and Examples 4-70 to Examples 4-75, when 0.1 wt% is included and the content of cetylpyridinium chloride is 0.001 wt%. Bacteria, fungi, and fungi are all included when the content of roxiacetophenone (4'-hydroxyacetophenone) is 0.04% and 0.001% by weight, while cetylpyridinium chloride is 0.04% and 0.001% by weight, respectively. It can be seen that the killing rate of the bacteria is less than 99.9%, so the antibacterial efficiency is not satisfied.

Therefore, in order to have an antibacterial activity having a bactericidal rate of 99.9% or more against all bacteria, fungi, and fungi, the cosmetic composition of the present invention, if the content of 4'-hydroxyacetophenone is 0.1% by weight, the cetylpyridinium chloride is 0.001 It is preferable that the content is more than 0.001% by weight and 30% by weight or less, and if the content of 4'-hydroxyacetophenone is 0.4% by weight or less, the cetylpyridinium chloride exceeds 0.04% by weight. It is preferably included in an amount of more than 30% by weight or more.

Meanwhile, technical terms used in the present invention should be interpreted as meanings generally understood by a person having ordinary knowledge in the technical field to which the present invention pertains, unless otherwise defined in the present invention. It should not be interpreted as a meaning or an excessively reduced meaning. In addition, the general terms used in the present invention should be interpreted as defined in the dictionary or in context before and after.

In addition, the singular expression used in the present invention includes a plural expression unless the context clearly indicates otherwise. In the present specification, terms such as'consisting of','consisting of' or'comprising' are not to be construed as including all of the various elements or various steps described in the specification, and some of them. Or it should be construed that some steps may not be included, or may further include additional components or steps.

Claims (16)

4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight;
Cetylpyridinium chloride 0.001 to 30% by weight; And
Cosmetic composition, characterized in that it comprises; the remaining amount of water so that the total weight of the total composition is 100% by weight. 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight;
Cetylpyridinium chloride 0.001 to 30% by weight;
0.01 to 0.04% by weight of any one compound selected from sodium dehydroacetate, sodium benzoate, caprylhydroxamic acid and alkanediol; And
Cosmetic composition, characterized in that it comprises; the remaining amount of water so that the total weight of the total composition is 100% by weight. According to claim 2,
The cosmetic composition,
If the content of the 4'-hydroxyacetophenone is 0.1% by weight, the cetylpyridinium chloride is a cosmetic composition characterized in that it contains more than 0.001% by weight. According to claim 2,
The cosmetic composition,
When the content of the 4'-hydroxyacetophenone is 0.4% by weight or less, the cosmetic composition characterized in that the cetylpyridinium chloride is contained in more than 0.04% by weight and 30% by weight or less. According to claim 2,
The alkanediol cosmetic composition, characterized in that at least one selected from octadiol (octandiol), hexanediol (hexandiol) and propanediol (propandiol). The method according to claim 1 or 2,
The cosmetic composition,
Cosmetic composition comprising at least one compound selected from chlorphenesin and tropolone. The method of claim 6,
The chlorphenesin (chlorphenesin) and any one or more compounds selected from tropolone (tropolone) cosmetic composition, characterized in that 1 to 40% by weight based on the total weight of the composition. The method according to claim 1 or 2,
The cosmetic composition is Escherichia coli coli ), Staphylococcus aureus ( Staphyloccoccus aureus ), Pseudomonas aeruginosa , Candida albicans and cosmetic composition characterized by having antibacterial properties to both Aspergillus niger . The method according to claim 1 or 2,
The cosmetic composition is a cosmetic composition, characterized in that the pH is 3.0 to 5.0. 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight; Cetylpyridinium chloride 0.001 to 30% by weight; And preparing a cosmetic composition by adding and stirring the remaining amount of water so that the total weight of the total composition is 100% by weight. 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight; Cetylpyridinium chloride 0.001 to 30% by weight; 0.01 to 0.04% by weight of any one compound selected from sodium dehydroacetate, sodium benzoate, caprylhydroxamic acid and alkanediol; And preparing a cosmetic composition by adding and stirring the remaining amount of water so that the total weight of the total composition is 100% by weight. The method of claim 10 or 11,
If the content of the 4'-hydroxyacetophenone in the cosmetic composition is 0.1% by weight, the cetylpyridinium chloride is 0.001% by weight of the cosmetic composition manufacturing method characterized in that it is included. The method of claim 10 or 11,
If the content of the 4'-hydroxyacetophenone in the cosmetic composition is 0.4% by weight or less, the cetylpyridinium chloride is 0.04% by weight or more and 30% by weight or less cosmetic composition manufacturing method comprising. The method of claim 11,
The alkanediol (alkanediol) is an octanediol (octandiol), hexanediol (hexandiol) and propanediol (propandiol) selected from any one or more cosmetic composition manufacturing method characterized in that. The method of claim 10 or 11,
The step of preparing the cosmetic composition,
Method for producing a cosmetic composition, characterized in that 1 to 40% by weight based on the total weight of the composition of any one or more compounds selected from chlorphenesin (chlorphenesin) and tropolone (tropolone) to the cosmetic composition. The method of claim 10 or 11,
And adjusting the pH concentration of the prepared cosmetic composition to be 3.0 to 5.0 after the step of preparing the cosmetic composition.