KR20230147851A - antimicrobial compositions with improved stability and persistence - Google Patents
antimicrobial compositions with improved stability and persistence Download PDFInfo
- Publication number
- KR20230147851A KR20230147851A KR1020220046699A KR20220046699A KR20230147851A KR 20230147851 A KR20230147851 A KR 20230147851A KR 1020220046699 A KR1020220046699 A KR 1020220046699A KR 20220046699 A KR20220046699 A KR 20220046699A KR 20230147851 A KR20230147851 A KR 20230147851A
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- potassium benzoate
- lauryl pyridinium
- antibacterial composition
- antibacterial
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 230000000845 anti-microbial effect Effects 0.000 title 1
- 230000002688 persistence Effects 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 44
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims abstract description 29
- 229940103091 potassium benzoate Drugs 0.000 claims abstract description 27
- 235000010235 potassium benzoate Nutrition 0.000 claims abstract description 27
- 239000004300 potassium benzoate Substances 0.000 claims abstract description 27
- GKQHIYSTBXDYNQ-UHFFFAOYSA-M 1-dodecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+]1=CC=CC=C1 GKQHIYSTBXDYNQ-UHFFFAOYSA-M 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000008213 purified water Substances 0.000 claims abstract description 4
- FFYRIXSGFSWFAQ-UHFFFAOYSA-N 1-dodecylpyridin-1-ium Chemical compound CCCCCCCCCCCC[N+]1=CC=CC=C1 FFYRIXSGFSWFAQ-UHFFFAOYSA-N 0.000 claims description 20
- 239000004480 active ingredient Substances 0.000 claims description 6
- 239000002537 cosmetic Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 239000003599 detergent Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- VFMHLPNWFWQNRQ-UHFFFAOYSA-L [Cl-].C(CCCCCCCCCCC)[N+]1=CC=CC=C1.[Cl-].C(CCCCCCCCCCC)[N+]1=CC=CC=C1 Chemical compound [Cl-].C(CCCCCCCCCCC)[N+]1=CC=CC=C1.[Cl-].C(CCCCCCCCCCC)[N+]1=CC=CC=C1 VFMHLPNWFWQNRQ-UHFFFAOYSA-L 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 abstract description 9
- 239000002609 medium Substances 0.000 description 21
- 241000894006 Bacteria Species 0.000 description 18
- 239000006150 trypticase soy agar Substances 0.000 description 18
- 239000001965 potato dextrose agar Substances 0.000 description 16
- 239000003755 preservative agent Substances 0.000 description 12
- 241000228245 Aspergillus niger Species 0.000 description 11
- 241000588724 Escherichia coli Species 0.000 description 10
- 239000000126 substance Substances 0.000 description 8
- 241000233866 Fungi Species 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 4
- 229920002413 Polyhexanide Polymers 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 244000265736 Nelumbo pentapetala Species 0.000 description 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- YIWGJFPJRAEKMK-UHFFFAOYSA-N 1-(2H-benzotriazol-5-yl)-3-methyl-8-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione Chemical compound CN1C(=O)N(c2ccc3n[nH]nc3c2)C2(CCN(CC2)C(=O)c2cnc(NCc3cccc(OC(F)(F)F)c3)nc2)C1=O YIWGJFPJRAEKMK-UHFFFAOYSA-N 0.000 description 1
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical group OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241001453380 Burkholderia Species 0.000 description 1
- 241000589513 Burkholderia cepacia Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000197975 Solidago virgaurea Species 0.000 description 1
- 235000000914 Solidago virgaurea Nutrition 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 206010069351 acute lung injury Diseases 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 1
- 229960001083 diazolidinylurea Drugs 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940107702 grapefruit seed extract Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- -1 polyhexamethylene guanidine Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47K—SANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR; TOILET ACCESSORIES
- A47K10/00—Body-drying implements; Toilet paper; Holders therefor
- A47K10/16—Paper towels; Toilet paper; Holders therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pest Control & Pesticides (AREA)
- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
본 발명은 항균 조성물에 관한 것으로서, 전체 100중량%에 대해 라우릴피리디늄클로라이드(cetylpyridinium chloride) 0.005중량% 이상 30중량% 이하와, 포타슘벤조에이트(potassium benzoate) 0.001중량% 이상 30중량% 이하와, 잔량으로서 정제수를 포함하는 것을 특징으로 한다.
상기와 같은 본 발명에 의하면, 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)와, 포타슘벤조에이트(potassium benzoate)를 적정 함량으로 배합하여 안정성 및 지속성이 향상됨에 따라 항균 및 방부가 요구되는 다양한 제품에 유용하게 사용될 수 있다.The present invention relates to an antibacterial composition, which contains 0.005% to 30% by weight of laurylpyridinium chloride and 0.001% to 30% by weight of potassium benzoate based on the total 100% by weight. , characterized in that it contains purified water as the remaining amount.
According to the present invention as described above, lauryl pyridinium chloride and potassium benzoate are mixed in an appropriate amount to improve stability and sustainability, making it useful for various products requiring antibacterial and preservative properties. It can be used effectively.
Description
본 발명은 항균 조성물에 관한 것으로서, 보다 상세하게는 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)와, 포타슘벤조에이트(Potassium Benzoate)를 적정 함량으로 배합하여 안정성 및 지속성이 향상된 항균 조성물에 관한 것이다.The present invention relates to an antibacterial composition, and more specifically, to an antibacterial composition with improved stability and sustainability by mixing Lauryl Pyridinium Chloride and Potassium Benzoate in appropriate amounts.
일반적으로 부패나 변패의 원인이 되는 진균류에 속하는 세균, 곰팡이 및 효모 등의 미생물을 사멸시키거나 그 증식을 억제하는 작용으로 미생물 증식이나 원하지 않는 화학적 변화로 인한 부패를 방지하고 일정 기간 보존하고자 식품, 화장품, 의약품 등과 같은 다양한 제품에 항균제 및 방부제가 사용되고 있다.In general, it kills or inhibits the growth of microorganisms such as bacteria, mold, and yeast belonging to the fungus class that cause spoilage or spoilage, preventing spoilage due to microbial growth or unwanted chemical changes and preserving food for a certain period of time. Antibacterial agents and preservatives are used in various products such as cosmetics and pharmaceuticals.
위와 같은 항균제 및 방부제로 사용되고 있는 물질로는 대부분 화학적으로 합성한 인공물질들이 사용되고 있으며 예를 들어, 클로로메틸이소치아졸리논(Chloromethylisothiazolinone, CMIT), 3-요오드-2-프로파이닐부틸카바메이트(3-lodo-2-propynylbutylcarbamate, IPBC), 벤잘코니윰클로라이드(Benzalkonium Chloride, BKC), PHMG(polyhexamethylene guanidine), PHMB(polyhexamethylene biguanide), 파라벤(Paraben)류, 이미다졸리디닐우레아, 디아졸리디닐 우레아, 알코올(Alchol) 등이 있다.Most of the substances used as antibacterial agents and preservatives above are chemically synthesized artificial substances, for example, chloromethylisothiazolinone (CMIT ), 3-iodine-2-propynylbutylcarbamate ( 3-lodo-2-propynylbutylcarbamate, IPBC ), Benzalkonium Chloride ( BKC ), PHMG ( polyhexamethylene guanidine ), PHMB ( polyhexamethylene biguanide ), Parabens, imidazolidinyl urea, diazolidinyl urea , alcohol, etc.
그러나, 상기 파라벤(Paraben)류 방부제는 피부 알르레기(Andrea Counti et al., Contact Dermatitis, 1997, 37; 35-36)와 환경 호르몬으로서의 가능성(Edwin et al., Toxicology and applied pharmacology, 1998, 153; 12-19) 및 내성균 유발 등의 문제점을 가지고 있다. 또한, PHMG, PHMB 및 PGH와 같은 구아디닌계 물질은 가습기용 살균제에 의한 급성폐손상 증후군의 원인물질로 위험성이 이슈화되는 등 많은 문제점이 있다.However, the paraben -type preservatives have the potential to cause skin allergies (Andrea Counti et al., Contact Dermatitis, 1997, 37; 35-36) and as environmental hormones (Edwin et al., Toxicology and applied pharmacology, 1998, 153; 12-19) and has problems such as causing resistant bacteria. In addition, guadinine-based substances such as PHMG, PHMB, and PGH have many problems, such as the risk of being a causative agent of acute lung injury syndrome caused by disinfectants for humidifiers.
상기한 바와 같이, 이러한 인공방부제의 위험성이 대두되고 있어 최근 화장품 및 식품 업계는 인체 독성이 최소화된 물질로서 파라벤 뿐만 아니라 방부제를 사용하고 있는 각종 화학물질들을 천연 소재 물질 등으로 대체하는 연구가 대두되고 있으며, 이러한 기술의 일 예로 한국등록특허 제10-0762303호에는 황금 추출물 10 내지 40 중량부, 목단피 추출물 10 내지 30 중량부 및 자몽종자 추출물 15 내지 40 중량부를 포함하는 천연 방부제 조성물이 개시되어 있고, 한국등록특허 제10-1525976호에는 용아초 추출물, 황련 추출물 및 용정자 추출물의 혼합물을 유효성분으로 함유하는 항균용 천연 복합 방부제 조성물로서, 상기 용아초 추출물 : 상기 황련 추출물 : 상기 용정차 추출물의 중량비는 2:1:2인 천연 복합 방부제 조성물에 대해 개시되어 있다.As mentioned above, the dangers of these artificial preservatives are rising, and recently, the cosmetics and food industries are conducting research to replace not only parabens but also various chemicals used as preservatives with natural materials as substances with minimal human toxicity. As an example of this technology, Korean Patent No. 10-0762303 discloses a natural preservative composition containing 10 to 40 parts by weight of goldenrod extract, 10 to 30 parts by weight of wood bark extract, and 15 to 40 parts by weight of grapefruit seed extract, Korean Patent No. 10-1525976 discloses an antibacterial natural complex preservative composition containing a mixture of Yongjaweed extract, Yellow lotus extract, and Yongseong tea extract as active ingredients, wherein the weight ratio of the Yongweed extract: The yellow lotus extract: The Yongjeong tea extract is A natural complex preservative composition of 2:1:2 is disclosed.
그러나, 상기한 천연 방부제 조성물은 천연 소재의 비싼 가격과 추출과정의 번잡함 및 천연 소재에 대한 가공 기술력의 미비 등으로 방부력이 저하된다는 문제가 있어 쉽게 사용하지 못하고 있는 실정이다.However, the natural preservative composition described above is not easily used due to the problem of reduced preservative power due to the high price of natural materials, the complexity of the extraction process, and lack of processing technology for natural materials.
또한, 천연활성 물질들의 경우, 대부분, 색취, 안정성 저하, 항균성이 떨어지며, 제형상의 문제점, 재연성 등으로 인하여 상용화되지 못하고 있다.In addition, in the case of natural active substances, most of them have poor color, poor stability, poor antibacterial properties, and are not commercialized due to problems in formulation, reproducibility, etc.
따라서 인체에 무해하거나 독성이 아주 낮아 장기적으로 사용하였을 때에도 전혀 해가 없어 안정적일 뿐 아니라 미생물에 대한 항균 작용이 강하고 지속적이여서 기존 사용하던 항균 및 방부 물질을 대체할 수 있는 항균 및 방부 물질의 개발이 절실하게 요구되고 있는 실정이다.Therefore, the development of antibacterial and preservative substances that are harmless to the human body or have very low toxicity is not only stable when used for a long period of time, but also has a strong and persistent antibacterial effect on microorganisms, so that it can replace existing antibacterial and preservative substances. It is urgently needed.
본 발명은 상기와 같은 문제점을 해결하기 위해 안출된 것으로서, 본 발명의 목적은 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)와, 포타슘벤조에이트(Potassium Benzoate)를 적정 함량으로 배합하여 안정성 및 지속성이 향상된 항균 조성물을 제공함에 있다.The present invention was devised to solve the above problems, and the purpose of the present invention is to improve stability and sustainability by combining Lauryl Pyridinium Cholride and Potassium Benzoate in appropriate amounts. To provide an antibacterial composition.
상기 목적을 달성하기 위한 본 발명에 따르면, 전체 100중량%에 대해 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride) 0.001중량% 이상 30중량% 이하와, 포타슘벤조에이트(Potassium Benzoate) 0.001중량% 이상 30중량% 이하와, 잔량으로서 정제수를 포함하되, 상기 포타슘벤조에이트(Potassium Benzoate)가 0.005중량% 이상인 경우 상기 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)는 0.001중량% 이상이고, 상기 포타슘벤조에이트(Potassium Benzoate)가 0.005중량% 미만인 경우 상기 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)는 0.005중량% 이상인 것을 특징으로 하는 안정성 및 지속성이 향상된 항균 조성물이 제공된다.According to the present invention for achieving the above object, 0.001% by weight to 30% by weight of Lauryl Pyridinium Chloride and 0.001% by weight to 30% by weight of Potassium Benzoate based on the total 100% by weight. % or less and the remaining amount includes purified water, but when the potassium benzoate is 0.005% by weight or more, the lauryl pyridinium chloride ( Lauryl Pyridinium Cholride ) is 0.001% by weight or more, and the potassium benzoate ( Potassium Benzoate) ) is less than 0.005% by weight, the lauryl pyridinium chloride ( Lauryl Pyridinium Cholride ) is provided as an antibacterial composition with improved stability and sustainability, characterized in that it is 0.005% by weight or more.
그리고, 상기 항균 조성물을 유효성분으로 포함하는 화장품, 동물용 의약외품, 물 티슈 및 세정제가 제공된다.Additionally, cosmetics, quasi-drugs for animals, wet tissues, and detergents containing the antibacterial composition as an active ingredient are provided.
상기와 같은 본 발명에 의하면, 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)와, 포타슘벤조에이트(Potassium Benzoate)를 적정 함량으로 배합하여 안정성 및 지속성이 향상됨에 따라 항균 및 방부가 요구되는 다양한 제품에 유용하게 사용될 수 있다.According to the present invention as described above, stability and sustainability are improved by mixing Lauryl Pyridinium Cholride and Potassium Benzoate in an appropriate amount, making it useful for various products requiring antibacterial and preservative properties. It can be used effectively.
도 1은 본 발명의 항균 조성물을 처리하지 않았을 경우, Tryptic Soy Agar(TSA) 배지에서 배양된 대장균(Escherichia coli)의 모습.
도 2는 본 발명의 항균 조성물을 처리하지 않았을 경우, Potato Dextrose Agar(PDA) 배지에서 배양된 아스퍼질러스 니거(Aspergillus niger)의 모습.
도 3은 포타슘벤조에이트(Potassium Benzoate)를 단독 사용한 본 발명의 항균 조성물을 처리한 경우, Tryptic Soy Agar(TSA) 배지에서 배양된 대장균(Escherichia coli)의 모습.
도 4는 포타슘벤조에이트(Potassium Benzoate)를 단독 사용한 본 발명의 항균 조성물을 처리한 경우, Potato Dextrose Agar(PDA) 배지에서 배양된 아스퍼질러스 니거(Aspergillus niger)의 모습.
도 5는 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)를 단독 사용한 본 발명의 항균 조성물을 처리한 경우, Tryptic Soy Agar(TSA) 배지에서 배양된 대장균(Escherichia coli)의 모습.
도 6은 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)를 단독 사용한 본 발명의 항균 조성물을 처리한 경우, Potato Dextrose Agar(PDA) 배지에서 배양된 아스퍼질러스 니거(Aspergillus niger)의 모습.
도 7은 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)와 포타슘벤조에이트(Potassium Benzoate)를 병행 사용한 본 발명의 항균 조성물을 처리한 경우, Tryptic Soy Agar(TSA) 배지에서 배양된 대장균(Escherichia coli)의 모습.
도 8은 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)와 포타슘벤조에이트(Potassium Benzoate)를 병행 사용한 본 발명의 항균 조성물을 처리한 경우, Potato Dextrose Agar(PDA) 배지에서 배양된 아스퍼질러스 니거(Aspergillus niger)의 모습.Figure 1 shows Escherichia coli cultured in Tryptic Soy Agar (TSA) medium when not treated with the antibacterial composition of the present invention.
Figure 2 shows Aspergillus niger cultured in Potato Dextrose Agar (PDA) medium when not treated with the antibacterial composition of the present invention.
Figure 3 shows Escherichia coli cultured in Tryptic Soy Agar (TSA) medium when treated with the antibacterial composition of the present invention using only potassium benzoate .
Figure 4 shows Aspergillus niger cultured in Potato Dextrose Agar (PDA) medium when treated with the antibacterial composition of the present invention using only potassium benzoate .
Figure 5 shows Escherichia coli cultured in Tryptic Soy Agar (TSA) medium when treated with the antibacterial composition of the present invention using Lauryl Pyridinium Cholride alone.
Figure 6 shows Aspergillus niger cultured in Potato Dextrose Agar (PDA) medium when treated with the antibacterial composition of the present invention using Lauryl Pyridinium Cholride alone.
Figure 7 shows the results of Escherichia coli cultured in Tryptic Soy Agar (TSA) medium when treated with the antibacterial composition of the present invention using Lauryl Pyridinium Cholride and Potassium Benzoate in combination. figure.
Figure 8 shows Aspergillus niger cultured in Potato Dextrose Agar (PDA) medium when treated with the antibacterial composition of the present invention using Lauryl Pyridinium Cholride and Potassium Benzoate in combination. niger ) appearance.
이하에서는 도면을 참조하여 본 발명을 보다 상세하게 설명한다. 도면들 중 동일한 구성요소들은 가능한 어느 곳에서든지 동일한 부호들로 나타내고 있음에 유의해야 한다. 또한 발명의 요지를 불필요하게 흐릴 수 있는 공지기능 및 구성에 대한 상세한 설명은 생략한다.Hereinafter, the present invention will be described in more detail with reference to the drawings. It should be noted that like elements in the drawings are represented by like symbols wherever possible. Additionally, detailed descriptions of known functions and configurations that may unnecessarily obscure the gist of the invention are omitted.
다음 표1에 기재된 바와 같은 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride) 및 포타슘벤조에이트(Potassium Benzoate) 화합물의 함량을 정제수에 넣고 완전히 용해되도록 교반기로 교반하여 본 발명의 제1실시예에 따른 항균 조성물을 제조하였다.The contents of Lauryl Pyridinium Chloride and Potassium Benzoate compounds as shown in Table 1 below were added to purified water and stirred with a stirrer to completely dissolve the antibacterial composition according to the first embodiment of the present invention. was manufactured.
하기 표1에서 “LPC”는 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride), “PBA”는 포타슘벤조에이트(Potassium Benzoate)를 의미한다.In Table 1 below, “LPC” refers to Lauryl Pyridinium Cholride and “PBA” refers to Potassium Benzoate .
표1에 나타낸 실시예 1-1 내지 1-64는 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride) 및 포타슘벤조에이트(Potassium Benzoate) 화합물의 함량을 표1과 같이 넣어 제조된 항균 조성물이다.Examples 1-1 to 1-64 shown in Table 1 are antibacterial compositions prepared by adding the contents of Lauryl Pyridinium Cholride and Potassium Benzoate compounds as shown in Table 1.
<표1><Table 1>
상기 실시예1에 따라 제조된 항균 조성물의 항균 활성을 확인하였으며, 그 결과는 표1에 나타내었다.The antibacterial activity of the antibacterial composition prepared according to Example 1 was confirmed, and the results are shown in Table 1.
구체적으로 본 발명에 따른 항균 조성물의 항균 활성 실험은 U.S.Pharmacopoeia 기준에 따라 수행하였으며, 균의 감소 및 사멸 정도를 확인하기 위해 평판 배양법으로 실험하였다.Specifically, the antibacterial activity test of the antibacterial composition according to the present invention was conducted according to the U.S. Pharmacopoeia standards, and was tested using a plate culture method to confirm the degree of reduction and death of bacteria.
항균 활성에 사용된 세균, 진균, 곰팡이는 한국생명공학연구원 생물자원센터(KCTC)로부터 분양 받았으며, 세균은 대장균(Escherichia coli), 황색포도상구균(Staphylococcus aureus), 녹농균(Pseudomonas aeruginosa), 부르크홀데리아(Burkholderia cepacia), 바실러스(Bacilus subtilis)가 혼합된 균을 이용하고, 진균은 칸디다 알비칸스(Candida albicans)균이며, 곰팡이는 아스페르질루스 나이거(Aspergillus niger) 균을 이용하여 항균 활성을 확인하였다.The bacteria, fungi, and mold used for antibacterial activity were distributed from the Korea Research Institute of Bioscience and Biotechnology Biological Resources Center (KCTC), and the bacteria were Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , and Burkholderia. Antibacterial activity was confirmed using a mixture of ( Burkholderia cepacia ) and Bacillus ( Bacillus subtilis ), the fungus being Candida albicans, and the mold being Aspergillus niger . did.
상기 실시예1에 따라 제조된 항균 조성물에 각각 균 배양액을 접종하고, 세균은 TSA(Tryptic Soy Agar) 평판 배지에 도포하고, 진균인 칸디다 알비칸스와 곰팡이인 아스페르질루스 나이거는 PDA(Patato Dextrose Agar) 평판 배지에 도포한 후, 30℃내지 35℃ 온도의 배양기(incubator)에서 배양하였다.Each bacterial culture was inoculated into the antibacterial composition prepared according to Example 1, the bacteria were applied to a TSA (Tryptic Soy Agar) plate medium, and the fungus Candida albicans and the mold Aspergillus niger were incubated with PDA (Patato Dextrose). Agar) plate medium and then cultured in an incubator at a temperature of 30°C to 35°C.
하기 표2에 기재된 ‘○’와‘Ⅹ’는 균의 사멸 여부를 표시한 것으로 대조군의 접종균수와 비교하여 아래 계산식1과 같이 계산된 균의 사멸율이 99.9% 이상이면 ‘○’로 나타내고, 균의 사멸율이 99.9% 미만이면 ‘Ⅹ’로 나타내었다. 여기서 대조군이란 상기 실시예1에 따라 제조된 항균 조성물 대신에 증류수에 균 배양액을 접종한 것이다.'○' and ' If the death rate of bacteria is less than 99.9%, it is indicated as 'Ⅹ'. Here, the control group refers to a bacterial culture inoculated into distilled water instead of the antibacterial composition prepared according to Example 1.
<계산식1><Calculation formula 1>
균의 사멸율(%)=((대조균의 접종균수-실시예의 잔존균수)/대조군의 접종균수)×100Bacterial death rate (%) = ((number of inoculum bacteria in control group - number of remaining bacteria in the example)/number of inoculum bacteria in control group) x 100
<표2><Table 2>
상기 표2에서 보는 바와 같이, 본 발명의 제1실시예에 따른 항균 조성물은 실시예1-8, 실시예1-16, 실시예1-24, 실시예1-32, 실시예1-40, 실시예1-48 및 실시예1-56과 같이 포타슘벤조에이트(Potassium Benzoate)를 단독으로 사용하는 경우와, 실시예1-55와 같이 포타슘벤조에이트(Potassium Benzoate) 함량이 0.001중량% 이상 0.005중량% 미만이면서 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)의 함량이 0.005중량% 미만인 경우와, 실시예1-57 내지 실시예1-63과 같이 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)을 단독으로 사용하는 경우에, 세균, 진균 및 곰팡이 중 적어도 하나에서 균의 사멸율이 99.9% 미만으로 항균 효율을 만족하지 못하는 것을 알 수 있다.As shown in Table 2, the antibacterial composition according to the first embodiment of the present invention is Examples 1-8, Examples 1-16, Examples 1-24, Examples 1-32, Examples 1-40, In the case of using potassium benzoate alone as in Examples 1-48 and 1-56, and in the case of using potassium benzoate alone as in Example 1-55, the potassium benzoate content is 0.001% by weight or more and 0.005% by weight. % and the content of Lauryl Pyridinium Cholride is less than 0.005% by weight, and Lauryl Pyridinium Cholride is used alone as in Examples 1-57 to 1-63. In this case, it can be seen that the death rate of bacteria in at least one of bacteria, fungi, and mold is less than 99.9%, which does not satisfy the antibacterial efficiency.
도1 및 도2는 본 발명의 제1실시예에 따른 항균 조성물을 처리하지 않았을 경우인 대조군으로 Tryptic Soy Agar(TSA) 배지에서 배양된 대장균(Escherichia coli) 및 Potato Dextrose Agar(PDA) 배지에서 배양된 아스퍼질러스 니거(Aspergillus niger)의 모습으로, 각각의 도1 및 도2에 도시된 바와 같이 평판 배지 전면에 걸쳐 균이 배양된 모습을 관찰할 수 있다.Figures 1 and 2 show Escherichia coli cultured in Tryptic Soy Agar (TSA) medium and Potato Dextrose Agar (PDA) medium as a control group when not treated with the antibacterial composition according to the first embodiment of the present invention. As the appearance of Aspergillus niger , it can be observed that the bacteria are cultured all over the plate medium, as shown in Figures 1 and 2, respectively.
그리고, 도3 및 도4는 포타슘벤조에이트(Potassium Benzoate)를 단독으로 사용한 본 발명의 제1실시예에 따른 항균 조성물을 처리한 Tryptic Soy Agar(TSA) 배지에서 배양된 대장균(Escherichia coli) 및 Potato Dextrose Agar(PDA) 배지에서 배양된 아스퍼질러스 니거(Aspergillus niger)의 모습으로, 실시예1-8, 실시예1-16, 실시예1-24, 실시예1-32, 실시예1-40, 실시예1-48 및 실시예1-56의 실험결과와, 각각의 도3 및 도4에 도시된 바와 같이 평판 배지 전면에 걸쳐 균이 배양된 모습을 관찰할 수 있다.And, Figures 3 and 4 show Escherichia coli and Potato cultured on Tryptic Soy Agar (TSA) medium treated with the antibacterial composition according to the first embodiment of the present invention using potassium benzoate alone. Aspergillus niger cultured in Dextrose Agar (PDA) medium, Examples 1-8, Examples 1-16, Examples 1-24, Examples 1-32, and Examples 1-40 , the experimental results of Examples 1-48 and 1-56, and as shown in Figures 3 and 4, respectively, the appearance of bacteria cultured over the entire plate medium can be observed.
또한, 도5 및 도6은 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)를 단독으로 사용한 본 발명의 제1실시예에 따른 항균 조성물을 처리한 Tryptic Soy Agar(TSA) 배지에서 배양된 대장균(Escherichia coli) 및 Potato Dextrose Agar(PDA) 배지에서 배양된 아스퍼질러스 니거(Aspergillus niger)의 모습으로, 아스퍼질러스 니거(Aspergillus niger)의 경우, 실시예1-57 내지 실시예1-60의 실험결과와, 도6에 도시된 바와 같이 배양 후에도 균이 사멸된 모습이 관찰된 것을 확인할 수 있으나, 대장균(Escherichia coli)의 경우, 실시예1-57 내지 실시예1-63의 실험결과와, 도5에 도시된 바와 같이 평판 배지 전면에 걸쳐 균이 배양된 모습이 관촬되는 것을 볼 때, 항균 효율을 만족하기 못하는 것을 알 수 있다.In addition, Figures 5 and 6 show Escherichia coli cultured in Tryptic Soy Agar (TSA) medium treated with the antibacterial composition according to the first embodiment of the present invention using Lauryl Pyridinium Cholride alone. ) and Aspergillus niger cultured in Potato Dextrose Agar (PDA) medium. In the case of Aspergillus niger , the experimental results of Examples 1-57 to 1-60 and , as shown in Figure 6, it can be confirmed that the bacteria were observed to be dead even after culturing. However, in the case of Escherichia coli , the experimental results of Examples 1-57 to 1-63 and Figure 5 As shown, when the bacteria are cultured all over the plate medium, it can be seen that the antibacterial efficiency is not satisfied.
이와는 달리, 도7 및 도8은 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)와 포타슘벤조에이트(Potassium Benzoate)를 병행 사용하되, 포타슘벤조에이트(Potassium Benzoate) 0.005중량% 이상이면서 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride) 0.001중량% 이상이거나, 포타슘벤조에이트(Potassium Benzoate) 0.001중량% 이상 0.005중량% 미만이면서 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride) 0.005중량% 이상을 사용한 본 발명의 제1실시예에 따른 항균 조성물을 처리한 Tryptic Soy Agar(TSA) 배지에서 배양된 대장균(Escherichia coli) 및 Potato Dextrose Agar(PDA) 배지에서 배양된 아스퍼질러스 니거(Aspergillus niger)의 모습으로, 실시예1-1 내지 실시예1-7, 실시예1-9 내지 실시예1-15, 실시예1-17 내지 실시예1-23, 실시예1-25 내지 실시예1-31, 실시예1-33 내지 실시예 1-39, 실시예1-41 내지 실시예1-47 및 실시예1-49 내지 실시예1-54의 실험결과와, 각각의 도7 및 도8에 도시된 바와 같이, 배양된 후에도 균이 사멸된 모습이 관찰된 것을 확인할 수 있다.On the other hand, Figures 7 and 8 show the use of Lauryl Pyridinium Cholride and Potassium Benzoate in parallel, but with 0.005% by weight or more of Potassium Benzoate and Lauryl Pyridinium Chloride ( In the first embodiment of the present invention, more than 0.001% by weight of Lauryl Pyridinium Cholride, or more than 0.001% by weight but less than 0.005% by weight of Potassium Benzoate and more than 0.005% by weight of Lauryl Pyridinium Cholride are used. Escherichia coli cultured in Tryptic Soy Agar (TSA) medium treated with the following antibacterial composition and Aspergillus niger cultured in Potato Dextrose Agar (PDA) medium, Examples 1-1 to 1. Example 1-7, Example 1-9 to Example 1-15, Example 1-17 to Example 1-23, Example 1-25 to Example 1-31, Example 1-33 to Example As shown in the experimental results of 1-39, Examples 1-41 to 1-47, and Examples 1-49 to 1-54, and in Figures 7 and 8, respectively, the bacteria remained even after culture. It can be confirmed that the dead body has been observed.
그러므로 본 발명의 제1실시예에 따른 항균 조성물이 세균, 진균 및 곰팡이 모두에 대해 99.9% 이상의 균 사멸율을 갖기 위해서는 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)와 포타슘벤조에이트(Potassium Benzoate)를 병행 사용하되, 포타슘벤조에이트(Potassium Benzoate) 0.005중량% 이상이면서 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride) 0.001중량% 이상이거나, 포타슘벤조에이트(Potassium Benzoate) 0.001중량% 이상 0.005중량% 미만이면서 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride) 0.005중량% 이상을 사용하는 것이 바람직하다.Therefore, in order for the antibacterial composition according to the first embodiment of the present invention to have a bacterial killing rate of more than 99.9% for all bacteria, fungi, and mold , Lauryl Pyridinium Cholride and Potassium Benzoate must be combined. When used, it contains more than 0.005% by weight of Potassium Benzoate and more than 0.001% by weight of Lauryl Pyridinium Cholride, or more than 0.001% by weight but less than 0.005% by weight of Potassium Benzoate and less than 0.005% by weight of Lauryl Pyridinium Chloride. It is preferable to use 0.005% by weight or more of Lauryl Pyridinium Cholride .
비록 본 발명이 상기 바람직한 실시 예들과 관련하여 설명되어졌지만, 발명의 요지와 범위로부터 벗어남이 없이 다양한 수정이나 변형을 하는 것이 가능하다. 따라서, 첨부된 특허 청구범위는 본 발명의 요지에 속하는 이러한 수정이나 변형을 포함할 것이다.Although the present invention has been described in relation to the above preferred embodiments, various modifications and variations can be made without departing from the gist and scope of the invention. Accordingly, the appended patent claims are intended to cover such modifications or variations as fall within the subject matter of the present invention.
부호없음No sign
Claims (5)
상기 포타슘벤조에이트(Potassium Benzoate)가 0.005중량% 이상인 경우 상기 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)는 0.001중량% 이상이고, 상기 포타슘벤조에이트(Potassium Benzoate)가 0.005중량% 미만인 경우 상기 라우릴피리디늄클로라이드(Lauryl Pyridinium Cholride)는 0.005중량% 이상인 것을 특징으로 하는 안정성 및 지속성이 향상된 항균 조성물.
Based on the total 100% by weight, it includes 0.001% to 30% by weight of Lauryl Pyridinium Chloride, 0.001% to 30% by weight of Potassium Benzoate, and purified water as the balance,
When the potassium benzoate is 0.005% by weight or more, the lauryl pyridinium chloride ( Lauryl Pyridinium Cholride ) is 0.001% by weight or more, and when the potassium benzoate is less than 0.005% by weight, the lauryl pyridinium chloride Lauryl Pyridinium Cholride is an antibacterial composition with improved stability and sustainability, characterized in that it contains 0.005% by weight or more.
A cosmetic comprising the antibacterial composition of claim 1 as an active ingredient.
A quasi-drug containing the antibacterial composition of claim 1 as an active ingredient.
A wet tissue containing the antibacterial composition of claim 1 as an active ingredient.
A detergent comprising the antibacterial composition of claim 1 as an active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020220046699A KR20230147851A (en) | 2022-04-15 | 2022-04-15 | antimicrobial compositions with improved stability and persistence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020220046699A KR20230147851A (en) | 2022-04-15 | 2022-04-15 | antimicrobial compositions with improved stability and persistence |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230147851A true KR20230147851A (en) | 2023-10-24 |
Family
ID=88515267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020220046699A KR20230147851A (en) | 2022-04-15 | 2022-04-15 | antimicrobial compositions with improved stability and persistence |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR20230147851A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100762303B1 (en) | 2007-06-07 | 2007-10-04 | 박병화 | Composition of natural preservatives and pharmaceutical composition the same |
| KR101525976B1 (en) | 2014-06-13 | 2015-06-05 | (주)모아캠 | Natural preservative composition containing Agrimonia Pilosa Extract, Coptis Chinensis Root Extract and Green Tea Extract |
-
2022
- 2022-04-15 KR KR1020220046699A patent/KR20230147851A/en not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100762303B1 (en) | 2007-06-07 | 2007-10-04 | 박병화 | Composition of natural preservatives and pharmaceutical composition the same |
| KR101525976B1 (en) | 2014-06-13 | 2015-06-05 | (주)모아캠 | Natural preservative composition containing Agrimonia Pilosa Extract, Coptis Chinensis Root Extract and Green Tea Extract |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Aiemsaard et al. | The effect of lemongrass oil and its major components on clinical isolate mastitis pathogens and their mechanisms of action on Staphylococcus aureus DMST 4745 | |
| CN100508963C (en) | Antimicrobial compositions | |
| KR101140473B1 (en) | Antimicrobial compositions | |
| EP3288380B1 (en) | Synergistic preservative compositions | |
| McCarthy et al. | The antimicrobial action of zinc ion/antioxidant combinations | |
| CN101557707B (en) | Compositions | |
| US20090176887A1 (en) | Biocidal Compositions and Methods | |
| CN101291581A (en) | Antimicrobial composition and method | |
| WO2019090098A1 (en) | Boosters for antimicrobial, preservative and biocidal applications | |
| EP1769678A2 (en) | Preservative blends containing quaternary ammonium compounds | |
| US8147877B2 (en) | Essential oils based disinfecting compositions having tuberculocidal and fungicidal efficacies | |
| Nostro et al. | Efficiency of Calamintha officinalis essential oil as preservative in two topical product types | |
| US6447793B2 (en) | Water soluble, broad spectrum preservative system | |
| MX2007001763A (en) | Synergistic preservative systems and their use in cosmetic compositions. | |
| CN106413404A (en) | Improved biocide compositions based on calcium fluoride as well as uses thereof | |
| Narayanan et al. | Self‐preserving personal care products | |
| CN105875592A (en) | Composite medicine for killing neurospore crassa | |
| KR20230147851A (en) | antimicrobial compositions with improved stability and persistence | |
| US20090227675A1 (en) | Antimicrobial Compositions | |
| CN106794122B (en) | Compositions containing meso-2, 3-butanediol | |
| KR20160046638A (en) | Antibacterial Composition containing meso-2,3-butanediol | |
| KR102394120B1 (en) | Antimicrobial composition comprising alkanediol and reuterin and use thereof | |
| KR102591676B1 (en) | Quaternary amine formulations and their uses | |
| CN100560071C (en) | Bactericidal composition | |
| CN111000743B (en) | Cocoamidopropyl PG-dimethyl ammonium chloride and polyalcohol compound and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E902 | Notification of reason for refusal |