KR102134467B1 - Cosmetic composition and preparation method of the same - Google Patents

Abstract

The present invention relates to a cosmetic composition, 4'-hydroxyacetophenone (4'-hydroxyacetophenone) and alkanediol (alkanediol) by containing hexanediol (hexandiol) and octanediol (octandiol) hypoallergenic and broad antibacterial activity to the skin It relates to a cosmetic composition having a and a method for manufacturing the same.

Description

Cosmetic composition and method for manufacturing the same{COSMETIC COMPOSITION AND PREPARATION METHOD OF THE SAME}

The present invention relates to a cosmetic composition having a wide range of antibacterial and antiseptic activity and a method for manufacturing the same.

In general, it kills microorganisms such as bacteria, fungi and yeast belonging to the fungi that cause decay or deterioration, or inhibits their growth.It is a food to prevent spoilage due to microbial growth or unwanted chemical changes and to preserve it for a certain period of time. Preservatives are used in various products such as cosmetics and medicines.

In general, most chemically synthesized artificial substances are used as materials used as a preservative, for example, chloromethylisothiazolinone (CMIT), 3-iodo-2-propynylbutyl carbamate (3- lodo-2-propynylbutylcarbamate (IPBC), Benzalkonium Chloride (BKC), polyhexamethylene guanidine (PHMG), polyhexamethylene biguanide (PHMB), parabens, imidazolidinyl urea, diazolidinyl urea, alcohol (Alchol) and others are used as antibacterial and antiseptic agents.

However, the paraben (Paraben) preservatives have problems such as skin allergy and resistant bacteria. In addition, guadinine-based substances such as PHMG, PHMB and PGH have many problems, such as risks, as a causative agent of acute lung injury symptoms caused by disinfectants for humidifiers.

As described above, the risk of such artificial preservatives has emerged, and recently, the cosmetics and food industry is researched to replace various chemicals used as preservatives as well as parabens as substances with minimal human toxicity. have. However, due to the high price of natural materials and the lack of processing technology for natural materials, natural materials cannot be used as preservatives. In addition, in the case of natural active materials, most of them are not commercialized due to poor color, stability, and antimicrobial properties, problems with formulations, and reproducibility.

Therefore, it is required to develop an antibacterial and antiseptic substance that is not only harmless and persistent to the human body that is capable of substituting the previously used antibacterial and antiseptic substances, and is harmless to the human body or has very low toxicity, and is harmless even when used for a long time. have.

Andrea Counti et al., Contact Dermatitis, 1997, 37; 35-36

The present invention is to solve the problems of the preservatives currently being used as described above, it is harmless to the human body and has no irritation to the skin, and suggests a cosmetic composition having improved antibacterial and antiseptic power against bacteria and fungi and a method for manufacturing the same The purpose.

To achieve the above object, the cosmetic composition of the present invention is 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 5% by weight, hexanediol (hexandiol) 0.001 to 5% by weight, octanediol (octandiol) 0.001 To 5% by weight, and a residual amount of water such that the total weight of the total composition is 100% by weight.

In the cosmetic composition, when the content of the hexanediol (hexandiol) is less than 1% by weight and the octandiol is greater than 0.005% by weight and less than 5% by weight, the 4'-hydroxyacetophenone (4'-hydroxyacetophenone) It is preferable to contain 0.05% by weight or more and 5% by weight or less.

In the cosmetic composition, chlorphenesin (chlorphenesin) and one or more compounds selected from tropolone (tropolone) may further include 1 to 40% by weight based on the total weight of the composition.

The cosmetic composition is Escherichia coli coli ), Staphylococcus aureus ( Staphyloccoccus aureus), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Candida albicans (Candida albicans ) and Aspergillus niger .

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The cosmetic composition of the present invention can be used by additionally adding substances such as moisturizer, ultraviolet absorber, vitamins, whitening agent, astringent, and animal and vegetable extracting ingredients to a conventional cosmetic, as long as the above effects are not impaired.

In addition, the formulation of the cosmetic composition may be any one or more selected from aqueous solutions, emulsions, dispersions, suspensions, and useful solutions, and is not necessarily limited thereto, and may take a wide range of formulations in various cosmetic formulations. .

In addition, in order to achieve the above object, the method of preparing the cosmetic composition of the present invention is 4'-hydroxyacetophenone (4'-hydroxyacetophenone), hexanediol (hexandiol) and octanediol (octandiol) and stirred by It may include the step of preparing a cosmetic composition.

The step of preparing the cosmetic composition comprises 0.001 to 5% by weight of the 4'-hydroxyacetophenone, 0.001 to 5% by weight of hexanediol and octandiol based on 100% by weight of the total composition. ) 0.001 to 5% by weight.

And in the step of preparing the cosmetic composition, any one or more compounds selected from chlorphenesin and tropolone may be added to the cosmetic composition in an amount of 1 to 40% by weight based on the total weight of the composition.

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In the cosmetic composition of the present invention, organic acids such as hexanediol and octandiol are presented as alkanediol, but the present invention is not limited thereto, and organic acids having antibacterial effects known to those skilled in the art It can be used by further including.

The cosmetic composition of the present invention has a wide range of antibacterial or antiseptic activity, including fungi and bacteria, but has low skin irritation and harmlessness to the human body, and thus has high stability, and thus can be usefully used in various cosmetic products as an antibacterial and antiseptic.

Hereinafter, the present invention will be described in more detail through Examples, but these Examples are only examples of cosmetic compositions for the present invention, and the scope of the present invention is not limited to these Examples, and does not depart from the technical spirit of the present invention. It will be apparent to those skilled in the art that various modifications, variations, and changes can be made within the scope of the present invention, and it is obvious that portions easily changeable by those skilled in the art are included in the scope of the present invention.

4'-hydroxyacetophenone (4'-hydroxyacetophenone), hexanediol (hexandiol) and octandiol (octandiol) components and contents as shown in Tables 1 to 7 were added to purified water and stirred with a stirrer to completely dissolve. The cosmetic composition of the example was prepared.

4'-hydroxyacetophenone (4'-hydroxyacetophenone) used in the cosmetic composition of the present invention is a substance designated by the Ministry of Food and Drug Safety as a safe ingredient with antioxidant and skin irritation effects.

Hexanediol is a preservative substance, and 1,2-hexanediol (1,2-hexanediol), 1,6-hexanediol (1,6-hexanediol), 2,5-hexanediol (2,5-hexanediol), etc. It can be used, preferably 1,2-hexanediol (1,2-hexanediol) is used.

And octanediol is one material of a conventional moisturizer or solubilizer, 1,2-octanediol (1,2-octanediol), 3,6-octanediol (3,6-octanediol), and the like can be used, preferably Uses 1,2-octanediol, also called caprylyl glycol.

4'-hydroxyacetophenone (4'-hydroxyacetophenone), hexanediol (hexandiol) and octandiol (octandiol) as an ingredient contained in the cosmetic composition of the present invention is prepared using a conventionally known method of the present invention It may be included in the cosmetic composition, it is also possible to use a commercially available product in the cosmetic composition of the present invention.

In Tables 1 to 7, "4'-HDP" is 4'-hydroxyacetophenone, "HXD" is 1,2-hexanediol (hexandiol), "OTD" is 1, It means 2 octandiol.

In Examples 1-1 to 1-49 shown in Table 1, the content of 1,2-hexanediol (hexandiol) was 5% by weight, and the remaining 1,2-octandiol and 4'-hydroxy It is a cosmetic composition prepared by putting the components and contents of acetophenone (4'-hydroxyacetophenone) as shown in Table 1 below.

division HXD OTD 4'-HDP Purified water weight% Example 1-1 5 5 5 Remaining amount (to 100) Example 1-2 5 5 3 Remaining amount (to 100) Example 1-3 5 5 One Remaining amount (to 100) Example 1-4 5 5 0.5 Remaining amount (to 100) Example 1-5 5 5 0.1 Remaining amount (to 100) Example 1-6 5 5 0.05 Remaining amount (to 100) Example 1-7 5 5 0.001 Remaining amount (to 100) Example 1-8 5 3 5 Remaining amount (to 100) Example 1-9 5 3 3 Remaining amount (to 100) Example 1-10 5 3 One Remaining amount (to 100) Example 1-11 5 3 0.5 Remaining amount (to 100) Example 1-12 5 3 0.1 Remaining amount (to 100) Example 1-13 5 3 0.05 Remaining amount (to 100) Example 1-14 5 3 0.001 Remaining amount (to 100) Example 1-15 5 One 5 Remaining amount (to 100) Example 1-16 5 One 3 Remaining amount (to 100) Example 1-17 5 One One Remaining amount (to 100) Example 1-18 5 One 0.5 Remaining amount (to 100) Example 1-19 5 One 0.1 Remaining amount (to 100) Example 1-20 5 One 0.05 Remaining amount (to 100) Example 1-21 5 One 0.001 Remaining amount (to 100) Example 1-22 5 0.5 5 Remaining amount (to 100) Example 1-23 5 0.5 3 Remaining amount (to 100) Example 1-24 5 0.5 One Remaining amount (to 100) Example 1-25 5 0.5 0.5 Remaining amount (to 100) Example 1-26 5 0.5 0.1 Remaining amount (to 100) Example 1-27 5 0.5 0.05 Remaining amount (to 100) Example 1-28 5 0.5 0.001 Remaining amount (to 100) Example 1-29 5 0.15 5 Remaining amount (to 100) Example 1-30 5 0.15 3 Remaining amount (to 100) Example 1-31 5 0.15 One Remaining amount (to 100) Example 1-32 5 0.15 0.5 Remaining amount (to 100) Example 1-33 5 0.15 0.1 Remaining amount (to 100) Example 1-34 5 0.15 0.05 Remaining amount (to 100) Example 1-35 5 0.15 0.001 Remaining amount (to 100) Example 1-36 5 0.05 5 Remaining amount (to 100) Example 1-37 5 0.05 3 Remaining amount (to 100) Example 1-38 5 0.05 One Remaining amount (to 100) Example 1-39 5 0.05 0.5 Remaining amount (to 100) Example 1-40 5 0.05 0.1 Remaining amount (to 100) Example 1-41 5 0.05 0.05 Remaining amount (to 100) Example 1-42 5 0.05 0.001 Remaining amount (to 100) Example 1-43 5 0.001 5 Remaining amount (to 100) Example 1-44 5 0.001 3 Remaining amount (to 100) Example 1-45 5 0.001 One Remaining amount (to 100) Example 1-46 5 0.001 0.5 Remaining amount (to 100) Example 1-47 5 0.001 0.1 Remaining amount (to 100) Example 1-48 5 0.001 0.05 Remaining amount (to 100) Example 1-49 5 0.001 0.001 Remaining amount (to 100)

Example 2-1 to Example 2-49 shown in Table 2 is 1,2-hexanediol (hexandiol) content of 3% by weight, the remaining 1,2-octandiol (octandiol) and 4'-hydroxy It is a cosmetic composition prepared by putting the components and contents of acetophenone (4'-hydroxyacetophenone) as shown in Table 2 below.

division HXD OTD 4'-HDP Purified water weight% Example 2-1 3 5 5 Remaining amount (to 100) Example 2-2 3 5 3 Remaining amount (to 100) Example 2-3 3 5 One Remaining amount (to 100) Example 2-4 3 5 0.5 Remaining amount (to 100) Example 2-5 3 5 0.1 Remaining amount (to 100) Example 2-6 3 5 0.05 Remaining amount (to 100) Example 2-7 3 5 0.001 Remaining amount (to 100) Example 2-8 3 3 5 Remaining amount (to 100) Example 2-9 3 3 3 Remaining amount (to 100) Example 2-10 3 3 One Remaining amount (to 100) Example 2-11 3 3 0.5 Remaining amount (to 100) Example 2-12 3 3 0.1 Remaining amount (to 100) Example 2-13 3 3 0.05 Remaining amount (to 100) Example 2-14 3 3 0.001 Remaining amount (to 100) Example 2-15 3 One 5 Remaining amount (to 100) Example 2-16 3 One 3 Remaining amount (to 100) Example 2-17 3 One One Remaining amount (to 100) Example 2-18 3 One 0.5 Remaining amount (to 100) Example 2-19 3 One 0.1 Remaining amount (to 100) Example 2-20 3 One 0.05 Remaining amount (to 100) Example 2-21 3 One 0.001 Remaining amount (to 100) Example 2-22 3 0.5 5 Remaining amount (to 100) Example 2-23 3 0.5 3 Remaining amount (to 100) Example 2-24 3 0.5 One Remaining amount (to 100) Example 2-25 3 0.5 0.5 Remaining amount (to 100) Example 2-26 3 0.5 0.1 Remaining amount (to 100) Example 2-27 3 0.5 0.05 Remaining amount (to 100) Example 2-28 3 0.5 0.001 Remaining amount (to 100) Example 2-29 3 0.15 5 Remaining amount (to 100) Example 2-30 3 0.15 3 Remaining amount (to 100) Example 2-31 3 0.15 One Remaining amount (to 100) Example 2-32 3 0.15 0.5 Remaining amount (to 100) Example 2-33 3 0.15 0.1 Remaining amount (to 100) Example 2-34 3 0.15 0.05 Remaining amount (to 100) Example 2-35 3 0.15 0.001 Remaining amount (to 100) Example 2-36 3 0.05 5 Remaining amount (to 100) Example 2-37 3 0.05 3 Remaining amount (to 100) Example 2-38 3 0.05 One Remaining amount (to 100) Example 2-39 3 0.05 0.5 Remaining amount (to 100) Example 2-40 3 0.05 0.1 Remaining amount (to 100) Example 2-41 3 0.05 0.05 Remaining amount (to 100) Example 2-42 3 0.05 0.001 Remaining amount (to 100) Example 2-43 3 0.001 5 Remaining amount (to 100) Example 2-44 3 0.001 3 Remaining amount (to 100) Example 2-45 3 0.001 One Remaining amount (to 100) Example 2-46 3 0.001 0.5 Remaining amount (to 100) Example 2-47 3 0.001 0.1 Remaining amount (to 100) Example 2-48 3 0.001 0.05 Remaining amount (to 100) Example 2-49 3 0.001 0.001 Remaining amount (to 100)

In Examples 3-1 to 3-49 shown in Table 2, the content of 1,2-hexanediol (hexandiol) was 1% by weight, and the remaining 1,2-octandiol and 4'-hydroxy It is a cosmetic composition prepared by putting the components and contents of acetophenone (4'-hydroxyacetophenone) as shown in Table 3 below.

division HXD OTD 4'-HDP Purified water weight% Example 3-1 One 5 5 Remaining amount (to 100) Example 3-2 One 5 3 Remaining amount (to 100) Example 3-3 One 5 One Remaining amount (to 100) Example 3-4 One 5 0.5 Remaining amount (to 100) Example 3-5 One 5 0.1 Remaining amount (to 100) Example 3-6 One 5 0.05 Remaining amount (to 100) Example 3-7 One 5 0.001 Remaining amount (to 100) Example 3-8 One 3 5 Remaining amount (to 100) Example 3-9 One 3 3 Remaining amount (to 100) Example 3-10 One 3 One Remaining amount (to 100) Example 3-11 One 3 0.5 Remaining amount (to 100) Example 3-12 One 3 0.1 Remaining amount (to 100) Example 3-13 One 3 0.05 Remaining amount (to 100) Example 3-14 One 3 0.001 Remaining amount (to 100) Example 3-15 One One 5 Remaining amount (to 100) Example 3-16 One One 3 Remaining amount (to 100) Example 3-17 One One One Remaining amount (to 100) Example 3-18 One One 0.5 Remaining amount (to 100) Example 3-19 One One 0.1 Remaining amount (to 100) Example 3-20 One One 0.05 Remaining amount (to 100) Example 3-21 One One 0.001 Remaining amount (to 100) Example 3-22 One 0.5 5 Remaining amount (to 100) Example 3-23 One 0.5 3 Remaining amount (to 100) Example 3-24 One 0.5 One Remaining amount (to 100) Example 3-25 One 0.5 0.5 Remaining amount (to 100) Example 3-26 One 0.5 0.1 Remaining amount (to 100) Example 3-27 One 0.5 0.05 Remaining amount (to 100) Example 3-28 One 0.5 0.001 Remaining amount (to 100) Example 3-29 One 0.15 5 Remaining amount (to 100) Example 3-30 One 0.15 3 Remaining amount (to 100) Example 3-31 One 0.15 One Remaining amount (to 100) Example 3-32 One 0.15 0.5 Remaining amount (to 100) Example 3-33 One 0.15 0.1 Remaining amount (to 100) Example 3-34 One 0.15 0.05 Remaining amount (to 100) Example 3-35 One 0.15 0.001 Remaining amount (to 100) Example 3-36 One 0.05 5 Remaining amount (to 100) Example 3-37 One 0.05 3 Remaining amount (to 100) Example 3-38 One 0.05 One Remaining amount (to 100) Example 3-39 One 0.05 0.5 Remaining amount (to 100) Example 3-40 One 0.05 0.1 Remaining amount (to 100) Example 3-41 One 0.05 0.05 Remaining amount (to 100) Example 3-42 One 0.05 0.001 Remaining amount (to 100) Example 3-43 One 0.001 5 Remaining amount (to 100) Example 3-44 One 0.001 3 Remaining amount (to 100) Example 3-45 One 0.001 One Remaining amount (to 100) Example 3-46 One 0.001 0.5 Remaining amount (to 100) Example 3-47 One 0.001 0.1 Remaining amount (to 100) Example 3-48 One 0.001 0.05 Remaining amount (to 100) Example 3-49 One 0.001 0.001 Remaining amount (to 100)

In Examples 4-1 to 4-49 shown in Table 4, the content of 1,2-hexanediol (hexandiol) was 0.4% by weight, and the remaining 1,2-octandiol and 4'-hydroxy It is a cosmetic composition prepared by putting the components and contents of acetophenone (4'-hydroxyacetophenone) as shown in Table 4 below.

division HXD OTD 4'-HDP Purified water weight% Example 4-1 0.4 5 5 Remaining amount (to 100) Example 4-2 0.4 5 3 Remaining amount (to 100) Example 4-3 0.4 5 One Remaining amount (to 100) Example 4-4 0.4 5 0.5 Remaining amount (to 100) Example 4-5 0.4 5 0.1 Remaining amount (to 100) Example 4-6 0.4 5 0.05 Remaining amount (to 100) Example 4-7 0.4 5 0.001 Remaining amount (to 100) Example 4-8 0.4 3 5 Remaining amount (to 100) Example 4-9 0.4 3 3 Remaining amount (to 100) Example 4-10 0.4 3 One Remaining amount (to 100) Example 4-11 0.4 3 0.5 Remaining amount (to 100) Example 4-12 0.4 3 0.1 Remaining amount (to 100) Example 4-13 0.4 3 0.05 Remaining amount (to 100) Example 4-14 0.4 3 0.001 Remaining amount (to 100) Example 4-15 0.4 One 5 Remaining amount (to 100) Example 4-16 0.4 One 3 Remaining amount (to 100) Example 4-17 0.4 One One Remaining amount (to 100) Example 4-18 0.4 One 0.5 Remaining amount (to 100) Example 4-19 0.4 One 0.1 Remaining amount (to 100) Example 4-20 0.4 One 0.05 Remaining amount (to 100) Example 4-21 0.4 One 0.001 Remaining amount (to 100) Example 4-22 0.4 0.5 5 Remaining amount (to 100) Example 4-23 0.4 0.5 3 Remaining amount (to 100) Example 4-24 0.4 0.5 One Remaining amount (to 100) Example 4-25 0.4 0.5 0.5 Remaining amount (to 100) Example 4-26 0.4 0.5 0.1 Remaining amount (to 100) Example 4-27 0.4 0.5 0.05 Remaining amount (to 100) Example 4-28 0.4 0.5 0.001 Remaining amount (to 100) Example 4-29 0.4 0.15 5 Remaining amount (to 100) Example 4-30 0.4 0.15 3 Remaining amount (to 100) Example 4-31 0.4 0.15 One Remaining amount (to 100) Example 4-32 0.4 0.15 0.5 Remaining amount (to 100) Example 4-33 0.4 0.15 0.1 Remaining amount (to 100) Example 4-34 0.4 0.15 0.05 Remaining amount (to 100) Example 4-35 0.4 0.15 0.001 Remaining amount (to 100) Example 4-36 0.4 0.05 5 Remaining amount (to 100) Example 4-37 0.4 0.05 3 Remaining amount (to 100) Example 4-38 0.4 0.05 One Remaining amount (to 100) Example 4-39 0.4 0.05 0.5 Remaining amount (to 100) Example 4-40 0.4 0.05 0.1 Remaining amount (to 100) Example 4-41 0.4 0.05 0.05 Remaining amount (to 100) Example 4-42 0.4 0.05 0.001 Remaining amount (to 100) Example 4-43 0.4 0.001 5 Remaining amount (to 100) Example 4-44 0.4 0.001 3 Remaining amount (to 100) Example 4-45 0.4 0.001 One Remaining amount (to 100) Example 4-46 0.4 0.001 0.5 Remaining amount (to 100) Example 4-47 0.4 0.001 0.1 Remaining amount (to 100) Example 4-48 0.4 0.001 0.05 Remaining amount (to 100) Example 4-49 0.4 0.001 0.001 Remaining amount (to 100)

In Examples 5-1 to 5-5-Examples shown in Table 5, the content of 1,2-hexanediol (hexandiol) was 0.1% by weight, and the remaining 1,2-octandiol and 4'-hydroxy It is a cosmetic composition prepared by putting the components and contents of acetophenone (4'-hydroxyacetophenone) as shown in Table 5 below.

division HXD OTD 4'-HDP Purified water weight% Example 5-1 0.1 5 5 Remaining amount (to 100) Example 5-2 0.1 5 3 Remaining amount (to 100) Example 5-3 0.1 5 One Remaining amount (to 100) Example 5-4 0.1 5 0.5 Remaining amount (to 100) Example 5-5 0.1 5 0.1 Remaining amount (to 100) Example 5-6 0.1 5 0.05 Remaining amount (to 100) Example 5-7 0.1 5 0.001 Remaining amount (to 100) Example 5-8 0.1 3 5 Remaining amount (to 100) Example 5-9 0.1 3 3 Remaining amount (to 100) Example 5-10 0.1 3 One Remaining amount (to 100) Example 5-11 0.1 3 0.5 Remaining amount (to 100) Example 5-12 0.1 3 0.1 Remaining amount (to 100) Example 5-13 0.1 3 0.05 Remaining amount (to 100) Example 5-14 0.1 3 0.001 Remaining amount (to 100) Example 5-15 0.1 One 5 Remaining amount (to 100) Example 5-16 0.1 One 3 Remaining amount (to 100) Example 5-17 0.1 One One Remaining amount (to 100) Example 5-18 0.1 One 0.5 Remaining amount (to 100) Example 5-19 0.1 One 0.1 Remaining amount (to 100) Example 5-20 0.1 One 0.05 Remaining amount (to 100) Example 5-21 0.1 One 0.001 Remaining amount (to 100) Example 5-22 0.1 0.5 5 Remaining amount (to 100) Example 5-23 0.1 0.5 3 Remaining amount (to 100) Example 5-24 0.1 0.5 One Remaining amount (to 100) Example 5-25 0.1 0.5 0.5 Remaining amount (to 100) Example 5-26 0.1 0.5 0.1 Remaining amount (to 100) Example 5-27 0.1 0.5 0.05 Remaining amount (to 100) Example 5-28 0.1 0.5 0.001 Remaining amount (to 100) Example 5-29 0.1 0.15 5 Remaining amount (to 100) Example 5-30 0.1 0.15 3 Remaining amount (to 100) Example 5-31 0.1 0.15 One Remaining amount (to 100) Example 5-32 0.1 0.15 0.5 Remaining amount (to 100) Example 5-33 0.1 0.15 0.1 Remaining amount (to 100) Example 5-34 0.1 0.15 0.05 Remaining amount (to 100) Example 5-35 0.1 0.15 0.001 Remaining amount (to 100) Example 5-36 0.1 0.05 5 Remaining amount (to 100) Example 5-37 0.1 0.05 3 Remaining amount (to 100) Example 5-38 0.1 0.05 One Remaining amount (to 100) Example 5-39 0.1 0.05 0.5 Remaining amount (to 100) Example 5-40 0.1 0.05 0.1 Remaining amount (to 100) Example 5-41 0.1 0.05 0.05 Remaining amount (to 100) Example 5-42 0.1 0.05 0.001 Remaining amount (to 100) Example 5-43 0.1 0.001 5 Remaining amount (to 100) Example 5-44 0.1 0.001 3 Remaining amount (to 100) Example 5-45 0.1 0.001 One Remaining amount (to 100) Example 5-46 0.1 0.001 0.5 Remaining amount (to 100) Example 5-47 0.1 0.001 0.1 Remaining amount (to 100) Example 5-48 0.1 0.001 0.05 Remaining amount (to 100) Example 5-49 0.1 0.001 0.001 Remaining amount (to 100)

In Examples 6-1 to 6-49 shown in Table 6, the content of 1,2-hexanediol (hexandiol) was 3% by weight, and the remaining 1,2-octandiol and 4'-hydroxy It is a cosmetic composition prepared by putting the components and contents of acetophenone (4'-hydroxyacetophenone) as shown in Table 6 below.

division HXD OTD 4'-HDP Purified water weight% Example 6-1 0.05 5 5 Remaining amount (to 100) Example 6-2 0.05 5 3 Remaining amount (to 100) Example 6-3 0.05 5 One Remaining amount (to 100) Example 6-4 0.05 5 0.5 Remaining amount (to 100) Example 6-5 0.05 5 0.1 Remaining amount (to 100) Example 6-6 0.05 5 0.05 Remaining amount (to 100) Example 6-7 0.05 5 0.001 Remaining amount (to 100) Example 6-8 0.05 3 5 Remaining amount (to 100) Example 6-9 0.05 3 3 Remaining amount (to 100) Example 6-10 0.05 3 One Remaining amount (to 100) Example 6-11 0.05 3 0.5 Remaining amount (to 100) Example 6-12 0.05 3 0.1 Remaining amount (to 100) Example 6-13 0.05 3 0.05 Remaining amount (to 100) Example 6-14 0.05 3 0.001 Remaining amount (to 100) Example 6-15 0.05 One 5 Remaining amount (to 100) Example 6-16 0.05 One 3 Remaining amount (to 100) Example 6-17 0.05 One One Remaining amount (to 100) Example 6-18 0.05 One 0.5 Remaining amount (to 100) Example 6-19 0.05 One 0.1 Remaining amount (to 100) Example 6-20 0.05 One 0.05 Remaining amount (to 100) Example 6-21 0.05 One 0.001 Remaining amount (to 100) Example 6-22 0.05 0.5 5 Remaining amount (to 100) Example 6-23 0.05 0.5 3 Remaining amount (to 100) Example 6-24 0.05 0.5 One Remaining amount (to 100) Example 6-25 0.05 0.5 0.5 Remaining amount (to 100) Example 6-26 0.05 0.5 0.1 Remaining amount (to 100) Example 6-27 0.05 0.5 0.05 Remaining amount (to 100) Example 6-28 0.05 0.5 0.001 Remaining amount (to 100) Example 6-29 0.05 0.15 5 Remaining amount (to 100) Example 6-30 0.05 0.15 3 Remaining amount (to 100) Example 6-31 0.05 0.15 One Remaining amount (to 100) Example 6-32 0.05 0.15 0.5 Remaining amount (to 100) Example 6-33 0.05 0.15 0.1 Remaining amount (to 100) Example 6-34 0.05 0.15 0.05 Remaining amount (to 100) Example 6-35 0.05 0.15 0.001 Remaining amount (to 100) Example 6-36 0.05 0.05 5 Remaining amount (to 100) Example 6-37 0.05 0.05 3 Remaining amount (to 100) Example 6-38 0.05 0.05 One Remaining amount (to 100) Example 6-39 0.05 0.05 0.5 Remaining amount (to 100) Example 6-40 0.05 0.05 0.1 Remaining amount (to 100) Example 6-41 0.05 0.05 0.05 Remaining amount (to 100) Example 6-42 0.05 0.05 0.001 Remaining amount (to 100) Example 6-43 0.05 0.001 5 Remaining amount (to 100) Example 6-44 0.05 0.001 3 Remaining amount (to 100) Example 6-45 0.05 0.001 One Remaining amount (to 100) Example 6-46 0.05 0.001 0.5 Remaining amount (to 100) Example 6-47 0.05 0.001 0.1 Remaining amount (to 100) Example 6-48 0.05 0.001 0.05 Remaining amount (to 100) Example 6-49 0.05 0.001 0.001 Remaining amount (to 100)

Example 2-1 to Example 2-49 shown in Table 7 is 1,2-hexanediol (hexandiol) content of 3% by weight, the remaining 1,2-octandiol (octandiol) and 4'-hydroxy It is a cosmetic composition prepared by putting the components and contents of acetophenone (4'-hydroxyacetophenone) as shown in Table 7 below.

division HXD OTD 4'-HDP Purified water weight% Example 7-1 0.001 5 5 Remaining amount (to 100) Example 7-2 0.001 5 3 Remaining amount (to 100) Example 7-3 0.001 5 One Remaining amount (to 100) Example 7-4 0.001 5 0.5 Remaining amount (to 100) Example 7-5 0.001 5 0.1 Remaining amount (to 100) Example 7-6 0.001 5 0.05 Remaining amount (to 100) Example 7-7 0.001 5 0.001 Remaining amount (to 100) Example 7-8 0.001 3 5 Remaining amount (to 100) Example 7-9 0.001 3 3 Remaining amount (to 100) Example 7-10 0.001 3 One Remaining amount (to 100) Example 7-11 0.001 3 0.5 Remaining amount (to 100) Example 7-12 0.001 3 0.1 Remaining amount (to 100) Example 7-13 0.001 3 0.05 Remaining amount (to 100) Example 7-14 0.001 3 0.001 Remaining amount (to 100) Example 7-15 0.001 One 5 Remaining amount (to 100) Example 7-16 0.001 One 3 Remaining amount (to 100) Example 7-17 0.001 One One Remaining amount (to 100) Example 7-18 0.001 One 0.5 Remaining amount (to 100) Example 7-19 0.001 One 0.1 Remaining amount (to 100) Example 7-20 0.001 One 0.05 Remaining amount (to 100) Example 7-21 0.001 One 0.001 Remaining amount (to 100) Example 7-22 0.001 0.5 5 Remaining amount (to 100) Example 7-23 0.001 0.5 3 Remaining amount (to 100) Example 7-24 0.001 0.5 One Remaining amount (to 100) Example 7-25 0.001 0.5 0.5 Remaining amount (to 100) Example 7-26 0.001 0.5 0.1 Remaining amount (to 100) Example 7-27 0.001 0.5 0.05 Remaining amount (to 100) Example 7-28 0.001 0.5 0.001 Remaining amount (to 100) Example 7-29 0.001 0.15 5 Remaining amount (to 100) Example 7-30 0.001 0.15 3 Remaining amount (to 100) Example 7-31 0.001 0.15 One Remaining amount (to 100) Example 7-32 0.001 0.15 0.5 Remaining amount (to 100) Example 7-33 0.001 0.15 0.1 Remaining amount (to 100) Example 7-34 0.001 0.15 0.05 Remaining amount (to 100) Example 7-35 0.001 0.15 0.001 Remaining amount (to 100) Example 7-36 0.001 0.05 5 Remaining amount (to 100) Example 7-37 0.001 0.05 3 Remaining amount (to 100) Example 7-38 0.001 0.05 One Remaining amount (to 100) Example 7-39 0.001 0.05 0.5 Remaining amount (to 100) Example 7-40 0.001 0.05 0.1 Remaining amount (to 100) Example 7-41 0.001 0.05 0.05 Remaining amount (to 100) Example 7-42 0.001 0.05 0.001 Remaining amount (to 100) Example 7-43 0.001 0.001 5 Remaining amount (to 100) Example 7-44 0.001 0.001 3 Remaining amount (to 100) Example 7-45 0.001 0.001 One Remaining amount (to 100) Examples 7-46 0.001 0.001 0.5 Remaining amount (to 100) Example 7-47 0.001 0.001 0.1 Remaining amount (to 100) Example 7-48 0.001 0.001 0.05 Remaining amount (to 100) Example 7-49 0.001 0.001 0.001 Remaining amount (to 100)

The antibacterial activity of the cosmetic composition prepared in the above Example was confirmed, and the results are shown in Tables 8 to 14 below.

Specifically, the antibacterial activity experiment of the cosmetic composition of the present invention was performed according to the U. S. Pharmacopoeia standard, and tested by a plate culture method to confirm the reduction and killing of bacteria.

The bacteria and fungi used for antibacterial activity were pre-sold by the Korea Research Institute of Bioscience and Biotechnology (KCTC) and the bacteria were Escherichia coli ; Strain No. 2571), Staphylococcus aureus (Staphylococcus aureus; Strain No. 3881), Pseudomonas aeruginosa (Pseudomonas aeruginosa ; Strain No. 2513) are using the mixed bacteria, fungi Candida albicans (Candida albicans; and strain number 7965), bacteria, fungus Aspergillus and this (Aspergillus niger; strain No. 6089) antimicrobial activity using the fungus Was confirmed.

Each of the fungal cultures was inoculated into the cosmetic composition prepared in the above Example, and the bacteria were cultured on a TSA (Tryptic Soy Agar) plate exclusion, and the fungus Candida albicans and the fungus Aspergillus niger were PDAs (Potato Dextrose Agar). ) After being applied to the plate medium, cultured in an incubator at a temperature of 30°C to 35°C, and then cultured.

'○' and'X' in Table 6 below indicate whether or not the bacteria were killed, and compared with the number of inoculated bacteria in the control group, the calculated bacteria as shown in Formula 1 below is represented by'○', If the mortality rate of the bacteria is less than 99.9%, it is represented by'X'. Here, the control group is inoculated with the bacterial culture solution in distilled water instead of the cosmetic composition of the embodiment.

[Calculation formula 1]

Killing rate of bacteria (%) = ((number of inoculation bacteria in the control group-number of remaining bacteria in the example) / number of inoculation bacteria in the control group) × 100

Composition Germ Fungi mold Composition Germ Fungi mold Example 1-1 ○ ○ ○ Example 1-26 ○ ○ ○ Example 1-2 ○ ○ ○ Example 1-27 ○ ○ ○ Example 1-3 ○ ○ ○ Example 1-28 ○ ○ ○ Example 1-4 ○ ○ ○ Example 1-29 ○ ○ ○ Example 1-5 ○ ○ ○ Example 1-30 ○ ○ ○ Example 1-6 ○ ○ ○ Example 1-31 ○ ○ ○ Example 1-7 ○ ○ ○ Example 1-32 ○ ○ ○ Example 1-8 ○ ○ ○ Example 1-33 ○ ○ ○ Example 1-9 ○ ○ ○ Example 1-34 ○ ○ ○ Example 1-10 ○ ○ ○ Example 1-35 ○ ○ ○ Example 1-11 ○ ○ ○ Example 1-36 ○ ○ ○ Example 1-12 ○ ○ ○ Example 1-37 ○ ○ ○ Example 1-13 ○ ○ ○ Example 1-38 ○ ○ ○ Example 1-14 ○ ○ ○ Example 1-39 ○ ○ ○ Example 1-15 ○ ○ ○ Example 1-40 ○ ○ ○ Example 1-16 ○ ○ ○ Example 1-41 ○ ○ ○ Example 1-17 ○ ○ ○ Example 1-42 ○ ○ ○ Example 1-18 ○ ○ ○ Example 1-43 ○ ○ ○ Example 1-19 ○ ○ ○ Example 1-44 ○ ○ ○ Example 1-20 ○ ○ ○ Example 1-45 ○ ○ ○ Example 1-21 ○ ○ ○ Example 1-46 ○ ○ ○ Example 1-22 ○ ○ ○ Example 1-47 ○ ○ ○ Example 1-23 ○ ○ ○ Example 1-48 ○ ○ ○ Example 1-24 ○ ○ ○ Example 1-49 ○ ○ ○ Example 1-25 ○ ○ ○

As shown in Table 8, in the cosmetic composition of Examples 1-1 to 1-49 containing the content of 1,2-hexanediol (hexandiol) in 5% by weight, killing of bacteria in both bacteria, fungi and mold Since the rate is 99.9% or more, it can be seen that it has an antibacterial effect.

Composition Germ Fungi mold Composition Germ Fungi mold Example 2-1 ○ ○ ○ Example 2-26 ○ ○ ○ Example 2-2 ○ ○ ○ Example 2-27 ○ ○ ○ Example 2-3 ○ ○ ○ Example 2-28 ○ ○ ○ Example 2-4 ○ ○ ○ Example 2-29 ○ ○ ○ Example 2-5 ○ ○ ○ Example 2-30 ○ ○ ○ Example 2-6 ○ ○ ○ Example 2-31 ○ ○ ○ Example 2-7 ○ ○ ○ Example 2-32 ○ ○ ○ Example 2-8 ○ ○ ○ Example 2-33 ○ ○ ○ Example 2-9 ○ ○ ○ Example 2-34 ○ ○ ○ Example 2-10 ○ ○ ○ Example 2-35 ○ ○ ○ Example 2-11 ○ ○ ○ Example 2-36 ○ ○ ○ Example 2-12 ○ ○ ○ Example 2-37 ○ ○ ○ Example 2-13 ○ ○ ○ Example 2-38 ○ ○ ○ Example 2-14 ○ ○ ○ Example 2-39 ○ ○ ○ Example 2-15 ○ ○ ○ Example 2-40 ○ ○ ○ Example 2-16 ○ ○ ○ Example 2-41 ○ ○ ○ Example 2-17 ○ ○ ○ Example 2-42 ○ ○ ○ Example 2-18 ○ ○ ○ Example 2-43 ○ ○ ○ Example 2-19 ○ ○ ○ Example 2-44 ○ ○ ○ Example 2-20 ○ ○ ○ Example 2-45 ○ ○ ○ Example 2-21 ○ ○ ○ Example 2-46 ○ ○ ○ Example 2-22 ○ ○ ○ Example 2-47 ○ ○ ○ Example 2-23 ○ ○ ○ Example 2-48 ○ ○ ○ Example 2-24 ○ ○ ○ Example 2-49 ○ ○ ○ Example 2-25 ○ ○ ○

As in Table 9, even in the case of the cosmetic composition of Examples 2-1 to 2-49 containing the content of 1,2-hexanediol (hexandiol) in 3% by weight, the 1,2-hexanediol (hexandiol) ), as shown in Examples 1-1 to 1-49 containing the content of 5% by weight, the killing rate of the bacteria is 99.9% or more in both bacteria, fungi, and fungi, indicating that it has an antibacterial effect.

Composition Germ Fungi mold Composition Germ Fungi mold Example 3-1 ○ ○ ○ Example 3-26 ○ ○ ○ Example 3-2 ○ ○ ○ Example 3-27 X X ○ Example 3-3 ○ ○ ○ Example 3-28 X X ○ Example 3-4 ○ ○ ○ Example 3-29 ○ ○ ○ Example 3-5 ○ ○ ○ Example 3-30 ○ ○ ○ Example 3-6 X X ○ Example 3-31 ○ ○ ○ Example 3-7 X X ○ Example 3-32 ○ ○ ○ Example 3-8 ○ ○ ○ Example 3-33 ○ ○ ○ Example 3-9 ○ ○ ○ Example 3-34 X X ○ Example 3-10 ○ ○ ○ Example 3-35 X X ○ Example 3-11 ○ ○ ○ Example 3-36 ○ ○ ○ Example 3-12 ○ ○ ○ Example 3-37 ○ ○ ○ Example 3-13 X X ○ Example 3-38 ○ ○ ○ Example 3-14 X X ○ Example 3-39 X X ○ Example 3-15 ○ ○ ○ Example 3-40 X X ○ Example 3-16 ○ ○ ○ Example 3-41 X X ○ Example 3-17 ○ ○ ○ Example 3-42 X X ○ Example 3-18 ○ ○ ○ Example 3-43 ○ ○ ○ Example 3-19 ○ ○ ○ Example 3-44 ○ ○ ○ Example 3-20 X X ○ Example 3-45 ○ ○ ○ Example 3-21 X X ○ Example 3-46 X X ○ Example 3-22 ○ ○ ○ Example 3-47 X X ○ Example 3-23 ○ ○ ○ Example 3-48 X X ○ Example 3-24 ○ ○ ○ Example 3-49 X X ○ Example 3-25 ○ ○ ○

In the case where the content of 1,2-hexanediol (hexandiol) as 1% by weight as shown in Table 10, Examples 3-6, 3-7, 3-13, 3-14, 3-20, 3 The contents of 1,2-octanediol are 5 wt%, 3 wt%, 1 wt%, 0.5 wt% and 0.15 wt%, respectively, as in -21, 3-27, 3-28, 3-34 and 3-35 In the case where the content of 4'-hydroxyacetophenone is 0.05 wt% and 0.001 wt%, the mortality rate against fungi is 99.9% or more, but the antibacterial effect is 99.9%. It can be seen that the antibacterial efficiency is not satisfied.

And as in Examples 3-39 to 3-42 and 3-46 to 3-49, the content of 1,2-octanediol is contained in 0.05% by weight and 0.001% by weight, and the content of 4'-hydroxyacetophenone is 0.5. Even when included in weight%, 0.1%, 0.05%, and 0.001% by weight, the killing rate against fungi is more than 99.9%, and the antibacterial effect is less than 99.9%. You can see that you are not satisfied.

Composition Germ Fungi mold Composition Germ Fungi mold Example 4-1 ○ ○ ○ Example 4-26 ○ ○ ○ Example 4-2 ○ ○ ○ Example 4-27 X X X Example 4-3 ○ ○ ○ Example 4-28 X X X Example 4-4 ○ ○ ○ Example 4-29 ○ ○ ○ Example 4-5 ○ ○ ○ Example 4-30 ○ ○ ○ Example 4-6 X X X Example 4-31 ○ ○ ○ Example 4-7 X X X Example 4-32 ○ ○ ○ Example 4-8 ○ ○ ○ Example 4-33 ○ ○ ○ Example 4-9 ○ ○ ○ Example 4-34 X X X Example 4-10 ○ ○ ○ Example 4-35 X X X Example 4-11 ○ ○ ○ Example 4-36 X X X Example 4-12 ○ ○ ○ Example 4-37 X X X Example 4-13 X X X Example 4-38 X X X Example 4-14 X X X Example 4-39 X X X Example 4-15 ○ ○ ○ Example 4-40 X X X Example 4-16 ○ ○ ○ Example 4-41 X X X Example 4-17 ○ ○ ○ Example 4-42 X X X Example 4-18 ○ ○ ○ Example 4-43 X X X Example 4-19 ○ ○ ○ Example 4-44 X X X Example 4-20 X X X Example 4-45 X X X Example 4-21 X X X Example 4-46 X X X Example 4-22 ○ ○ ○ Example 4-47 X X X Example 4-23 ○ ○ ○ Example 4-48 X X X Example 4-24 ○ ○ ○ Example 4-49 X X X Example 4-25 ○ ○ ○

As in Table 11, when the content of 1,2-hexanediol (hexandiol) is included in 0.4% by weight, Examples 4-6, 4-7, 4-13, 4-14, 4-20, 3 The contents of 1,2-octanediol are 5 wt%, 3 wt%, 1 wt%, 0.5 wt% and 0.15 wt%, respectively, as in -21, 4-27, 4-28, 4-34 and 4-35. In the case where the content of 4'-hydroxyacetophenone was 0.05% by weight and 0.001% by weight, the killing rate of the bacteria was less than 99.9% in both bacteria, fungi, and fungi, so it was found that the antibacterial efficiency was not satisfied. .

And, as in Examples 4-36 to 4-49, when the content of 1,2-octanediol is 0.05% by weight and 0.001% by weight in 0.4% by weight of 1,2-hexanediol (hexandiol), bacteria, fungi, and It can be seen that in all the fungi, the killing rate of the bacteria is less than 99.9%, so the antibacterial efficiency is not satisfied.

Composition Germ Fungi mold Composition Germ Fungi mold Example 5-1 ○ ○ ○ Example 5-26 X X X Example 5-2 ○ ○ ○ Example 5-27 X X X Example 5-3 ○ ○ ○ Example 5-28 X X X Example 5-4 X X X Example 5-29 X X X Example 5-5 X X X Example 5-30 X X X Example 5-6 X X X Example 5-31 X X X Example 5-7 X X X Example 5-32 X X X Example 5-8 ○ ○ ○ Example 5-33 X X X Example 5-9 ○ ○ ○ Example 5-34 X X X Example 5-10 ○ ○ ○ Example 5-35 X X X Example 5-11 X X X Example 5-36 X X X Example 5-12 X X X Example 5-37 X X X Example 5-13 X X X Example 5-38 X X X Example 5-14 X X X Example 5-39 X X X Example 5-15 X X X Example 5-40 X X X Example 5-16 X X X Example 5-41 X X X Example 5-17 X X X Example 5-42 X X X Example 5-18 X X X Example 5-43 X X X Example 5-19 X X X Example 5-44 X X X Example 5-20 X X X Example 5-45 X X X Example 5-21 X X X Example 5-46 X X X Example 5-22 X X X Example 5-47 X X X Example 5-23 X X X Example 5-48 X X X Example 5-24 X X X Example 5-49 X X X Example 5-25 X X X

As in Table 12, when the content of 1,2-hexanediol (hexandiol) is included in 0.1% by weight, 1,2 as in Examples 5-4 to 5-7, 5-11 to 5-14 -When the content of octanediol is 5% by weight and 3% by weight, respectively, and the content of 4'-hydroxyacetophenone is 1% by weight, 0.5% by weight, 0.1% by weight, 0.05% by weight, and 0.001% by weight In the bacteria, fungi and fungi, the killing rate of the bacteria is less than 99.9%, so it can be seen that the antibacterial efficiency is not satisfied.

And as in Examples 5-15 to 5-49, 1,2-hexanediol (hexandiol) content of 1,2-octanediol from 0.1% by weight is 1% by weight, 0.5% by weight, 0.15% by weight, 0.05% by weight, and 0.001 When included as a weight percent, it can be seen that the killing rate of the bacteria is less than 99.9% in both bacteria, fungi, and fungi, and thus it is found that the antibacterial efficiency is not satisfied.

Composition Germ Fungi mold Composition Germ Fungi mold Example 6-1 X X X Example 6-26 X X X Example 6-2 X X X Example 6-27 X X X Example 6-3 X X X Example 6-28 X X X Example 6-4 X X X Example 6-29 X X X Example 6-5 X X X Example 6-30 X X X Example 6-6 X X X Example 6-31 X X X Example 6-7 X X X Example 6-32 X X X Example 6-8 X X X Example 6-33 X X X Example 6-9 X X X Example 6-34 X X X Example 6-10 X X X Example 6-35 X X X Example 6-11 X X X Example 6-36 X X X Example 6-12 X X X Example 6-37 X X X Example 6-13 X X X Example 6-38 X X X Example 6-14 X X X Example 6-39 X X X Example 6-15 X X X Example 6-40 X X X Example 6-16 X X X Example 6-41 X X X Example 6-17 X X X Example 6-42 X X X Example 6-18 X X X Example 6-43 X X X Example 6-19 X X X Example 6-44 X X X Example 6-20 X X X Example 6-45 X X X Example 6-21 X X X Example 6-46 X X X Example 6-22 X X X Example 6-47 X X X Example 6-23 X X X Example 6-48 X X X Example 6-24 X X X Example 6-49 X X X Example 6-25 X X X

As shown in Table 13, in the case of the cosmetic composition of Example 6-1 to Example 6-49 containing the content of 1,2-hexanediol (hexandiol) in 0.05% by weight, the killing of the bacteria in both bacteria, fungi and mold Since the rate is less than 99.9%, it can be seen that the antibacterial efficiency is not satisfied.

Composition Germ Fungi mold Composition Germ Fungi mold Example 7-1 X X X Example 7-26 X X X Example 7-2 X X X Example 7-27 X X X Example 7-3 X X X Example 7-28 X X X Example 7-4 X X X Example 7-29 X X X Example 7-5 X X X Example 7-30 X X X Example 7-6 X X X Example 7-31 X X X Example 7-7 X X X Example 7-32 X X X Example 7-8 X X X Example 7-33 X X X Example 7-9 X X X Example 7-34 X X X Example 7-10 X X X Example 7-35 X X X Example 7-11 X X X Example 7-36 X X X Example 7-12 X X X Example 7-37 X X X Example 7-13 X X X Example 7-38 X X X Example 7-14 X X X Example 7-39 X X X Example 7-15 X X X Example 7-40 X X X Example 7-16 X X X Example 7-41 X X X Example 7-17 X X X Example 7-42 X X X Example 7-18 X X X Example 7-43 X X X Example 7-19 X X X Example 7-44 X X X Example 7-20 X X X Example 7-45 X X X Example 7-21 X X X Examples 7-46 X X X Example 7-22 X X X Example 7-47 X X X Example 7-23 X X X Example 7-48 X X X Example 7-24 X X X Example 7-49 X X X Example 7-25 X X X

Even in the case of the cosmetic compositions of Examples 7-1 to 7-49 containing the content of 1,2-hexanediol (hexandiol) as 0.001% by weight, as in Table 14, the 1,2-hexanediol (hexandiol) ) Content of 0.05% by weight, as in Examples 6-1 to 6-49, the killing rate of the bacteria is less than 99.9% in both bacteria, fungi, and fungi, so it can be seen that the antibacterial efficiency is not satisfied. .

Through the results of such antibacterial effects, the cosmetic composition of the present invention has an hexanediol (hexandiol) content of 1% by weight or less in order to have an antibacterial activity having a bactericidal rate of 99.9% or more against all bacteria, fungi and fungi. If octandiol) is more than 0.005% by weight and 5% by weight or less, it is preferable that the 4'-hydroxyacetophenone (4'-hydroxyacetophenone) contains more than 0.05% by weight and 5% by weight or less, and the hexanediol (hexandiol) When the content of) is 1% by weight or less and the octandiol is 0.005% by weight or less, the 4'-hydroxyacetophenone is preferably contained in an amount of more than 0.5% by weight and 5% by weight or less. Do.

As described in the above embodiment, the cosmetic composition comprising 4'-hydroxyacetophenone (4'-hydroxyacetophenone), hexanediol (hexandiol) and octandiol of the present invention is the same as conventional parabens. It can be seen that it has excellent antiseptic power without using a chemical preservative, and at the same time, has less skin irritation and excellent stability.

Meanwhile, technical terms used in the present invention should be interpreted as meanings generally understood by a person having ordinary knowledge in the technical field to which the present invention pertains, unless otherwise defined in the present invention. It should not be interpreted as a meaning or an excessively reduced meaning. In addition, the general terms used in the present invention should be interpreted as defined in the dictionary or in context before and after.

In addition, the singular expression used in the present invention includes a plural expression unless the context clearly indicates otherwise. In the present specification, terms such as'consisting of','consisting of' or'comprising' are not to be construed as including all of the various elements or various steps described in the specification, and some of them. Or it should be construed that some steps may not be included, or may further include additional components or steps.

Claims (12)

4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 5% by weight;
Hexanediol (hexandiol) 0.001 to 5% by weight;
Octandiol 0.001 to 5% by weight; And
Including the remaining amount of water so that the total weight of the total composition is 100% by weight,
When the content of the hexanediol (hexandiol) is less than 1% by weight and the octandiol exceeds 0.005% by weight and less than 5% by weight, the 4'-hydroxyacetophenone is 0.05% by weight Exceeds 5% by weight,
When the content of the hexanediol (hexandiol) is 1 wt% or less and the octandiol is 0.005 wt% or less, the 4'-hydroxyacetophenone exceeds 0.5 wt% and 5 wt% Cosmetic composition comprising the following. delete delete According to claim 1,
The cosmetic composition,
Cosmetic composition comprising at least one compound selected from chlorphenesin and tropolone. According to claim 4,
The chlorphenesin (chlorphenesin) and any one or more compounds selected from tropolone (tropolone) cosmetic composition, characterized in that 1 to 40% by weight based on the total weight of the composition. According to claim 1,
The cosmetic composition is characterized by having antimicrobial activity against Escherichia coli, Staphyloccoccus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger Composition. delete 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 5% by weight; Hexanediol (hexandiol) 0.001 to 5% by weight; Octandiol 0.001 to 5% by weight; And preparing a cosmetic composition by adding and stirring the remaining amount of water so that the total weight of the total composition is 100% by weight.
In the cosmetic composition, if the content of the hexanediol (hexandiol) is 1 wt% or less and the octandiol exceeds 0.005 wt% and is 5 wt% or less, the 4'-hydroxyacetophenone (4'-hydroxyacetophenone) ) Exceeds 0.05% by weight and contains 5% by weight or less,
When the content of the hexanediol (hexandiol) is 1% by weight or less and the octandiol is 0.005% by weight or less, the 4'-hydroxyacetophenone is more than 0.5% by weight and 5% by weight or less Method for producing a cosmetic composition comprising a. delete delete The method of claim 8,
The step of preparing the cosmetic composition,
Method for producing a cosmetic composition, characterized in that 1 to 40% by weight based on the total weight of the composition of any one or more compounds selected from chlorphenesin (chlorphenesin) and tropolone (tropolone) to the cosmetic composition. delete