JP6388684B2 - Wet tissue composition with increased diffusivity in wet tissue stock containing lauryl pyridinium chloride and the wet tissue - Google Patents

Description

  The present invention relates to a wet tissue composition having increased diffusibility in a wet tissue stock containing laurylpyridinium chloride as a main component and a wet tissue containing the same.

  Wet wipes are non-woven fabrics containing moisture used to clean the human body. Since the mid-1950s, wet wipes have been used in homes, childcare facilities, welfare facilities for the elderly, restaurants, hospitals, etc. It has been used for various purposes. Early wet tissues were used primarily for travel cleaning applications, but recently infant skin cleaning, makeup and sweat pads, pain relief, personal hygiene, animal care, health care, working in the factory It is used for cleaning contaminants adhering to the skin, and uses are different depending on the components added in the wet tissue (Non-Patent Documents 1 and 2).

  Ingredients added to the wet tissue generally contain functional ingredients according to the purpose, such as moisturizers and fragrances, in purified water, and disinfectants and antiseptics can be stored for a long time when the tissue is wet. A preservative such as a preservative is essentially added. However, since wet tissue is generally not a product that is washed off with water after use, the preservative contained in the product is likely to remain on the skin as it is, and the product use site is sensitive to chemicals such as mouth and hands. Since it is a site, the skin should be less irritating, excellent in stability, and excellent in removing foreign substances and pathogenic microorganisms remaining on the skin.

  At present, cetylpyridinium chloride (CPC), one of the most widely used preservatives, is a quaternary ammonium cation, which has a bactericidal effect on bacteria and microorganisms, and plaque of teeth. ) It is known to be effective in preventing formation and reducing gingivitis, and is used in oral cleansing agents, toothpastes, oral sprays, nasal sprays, and wet tissues. However, cetylpyridinium chloride has a characteristic that a large amount of bubbles are generated and an antifoaming agent must be used together. In this case, contamination in the manufacturing process and problems in the process appear. There is a problem that the frequency of pop-up phenomenon of the tissue increases, the diffusion in the wet tissue base does not improve, and it is vulnerable to microbial contamination.

  Recently, in wet tissues using cetylpyridinium chloride and benzalkonium chloride (BKC) as preservatives, Burkholderia cepacia is a preservative, that is, a wet tissue preservative. It was confirmed that it proliferated in large quantities with acquired resistance to. Therefore, there is a need to develop a new wet tissue preservative that can replace cetylpyridinium chloride and benzalkonium chloride preservative.

  In order to overcome the limitations and disadvantages of cetylpyridinium chloride and benzalkonium chloride, the amount of Climbazole, which is often used in cosmetic preservative ingredients at home and abroad, is increasing. Crimbazole is a white crystalline powder that is known to have a low degree of irritation and risk compared to other ingredients in the EWG Skin Deep Grade, an environmental research non-profit organization in the United States. It is known to have an exclusive and persistent bactericidal effect against nasal fungi and trichophytic bacteria. However, Crimbazole is not soluble in water and is known to be a potentially toxic harmful substance.

  Therefore, there is an urgent need to develop a preservative that can replace cetylpyridinium chloride, benzalkonium chloride, and crimbazole, has excellent antifungal activity, and is harmless to the human body.

  Laurylpyridinium chloride (LPC, dodecylpyridinium chloride) is excellent in antibacterial effect and has low skin irritation. Moreover, it is a preservative suitable for application to wet tissues because of its good solubility in water and excellent diffusibility in the raw tissues when applied to wet tissues.

  Here, in the process of studying wet tissue compositions using lauryl pyridinium chloride as a preservative, the present inventors have demonstrated that the wet tissue composition containing lauryl pyridinium chloride as a main component has excellent antibacterial activity, and wet tissue. The present invention could be completed by confirming that the diffusibility in the raw material was excellent.

  Conventionally, as a prior art, Patent Document 1 describes laurylpyridinium chloride as an antibacterial / antifungal agent, but a method for reducing the adsorption rate of the antibacterial / antifungal agent on a wet tissue base and this Since cetylpyridinium chloride is described as an antibacterial and antifungal agent suitable for the above, there is a difference from the wet tissue composition containing laurylpyridinium chloride having the antibacterial effect and diffusibility of the present invention as a main component. Further, Patent Document 2 describes an antiseptic composition containing cetylpyridinium chloride. Therefore, the composition differs from the wet tissue composition containing laurylpyridinium chloride as a main component of the present invention. The antifungal composition produced in the form of a wet tissue is described, but the lauryl pyridinium chloride of the present invention is not described.

Japanese Patent No. 4030633, Method for reducing the amount of antibacterial and fungicidal adsorption, registered on 26 October 2007. Registered Korean Patent No. 1506185, antiseptic composition inhibiting quaternary ammonium compound resistant bacteria, Mar 20, 2015. US Patent No. 9226882, Eco-friendly non-aqueous antimicrobial composition comprising tropolone with 1,3-proranediol and / or sorbitan caprylate, registered on 01.05.2016.

Moo S.C., Bacterial Contamination in Disposable Wet Wipes from General Restaurants, Korean J. Clin. Lab. Sci., 48 (3), 237-241, 2016. Seo J.H., et al., Studies on the antibacterial activity of wet-tissue saturated with electrolytic water of NaCl solution, Journal of Korea TAPPI, 47 (6), 147-153, 2015.

  An object of the present invention is to provide a wet tissue composition having increased diffusibility in a wet tissue stock containing laurylpyridinium chloride as a main component.

  Another object of the present invention is to provide a wet tissue containing a wet tissue composition having increased diffusibility in a wet tissue stock containing lauryl pyridinium chloride as a main component.

  The present invention relates to a) laurylpyridinium chloride; and b) caprylhydroxamic acid, biphenylhydroxamic acid, cinnamoylhydroxamic acid, octanediol, hexanediol. (Hexanediol), propanediol (Propanediol), benzoic acid (Benzoic acid), sodium benzoate (Sodium benzoate), sorbic acid (Sorbic acid), potassium sorbate (Potassium sorbate), dehydroacetic acid (Dehydroacetic acid), dehydroacetic acid Sodium dehydroacetic acid, Propionic acid, Sodium propionate, Formic acid, Sodium formate, Hexamidine diisethionate, Capryloi Glycine (Capryloyl glycine), Undecylenoyl glycine (C12-C14 alkyl diaminoethyl glycine HCl), Lauryl diethylene diamino glycine, Lauryl aminopropyl glycine (Lauryl) The present invention relates to a wet tissue composition having increased diffusibility in a wet tissue stock containing one or more compounds selected from the group consisting of aminopropyl glycine, tropolone, and chlorphenesin.

  The wet tissue composition comprises: a) lauryl pyridinium chloride 0.01-30 wt%; and b) capryl hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, propanediol, benzoic acid, benzoic acid Sodium, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetoate, propionic acid, sodium propionate, formic acid, sodium formate, hexamidine diisethionate, capryloylglycine, undecylenoylglycine, C12-C14 alkyl One or more compounds selected from the group consisting of diaminoethylglycine HCL, lauryldiethylenediaminoglycine, laurylaminopropylglycine, tropolone, and chlorphenesin 0 001-40% by weight; may include.

  The wet tissue composition comprises lauryl pyridinium chloride and capryl hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, propanediol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid , Sodium dehydroacetoate, propionic acid, sodium propionate, formic acid, sodium formate, hexamidine diisethionate, capryloyl glycine, undecylenoyl glycine, C12-C14 alkyl diaminoethyl glycine HCL, lauryl diethylene diamino glycine, lauryl amino The weight ratio of one or more compounds selected from the group consisting of propylglycine, tropolone, and chlorphenesin is 1:10 to 10: 1. It can be mixed.

  The compound is preferably caprylic hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, propanediol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroaceto acid, sodium dehydroacetoate , Propionic acid, sodium propionate, formic acid, sodium formate, and more preferably capryl hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid.

  The wet tissue composition may further include a humectant and a pH adjuster.

  The wet tissue composition comprises Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterobacter hirae, Aspergillus brasiliensis, Candida albicans ), Mycobacterium terrae, and Burkholderia cepacia.

  In still another aspect, the present invention relates to a wet tissue containing the wet tissue composition.

  Hereinafter, the present invention will be described in detail.

  The wet tissue composition comprises: a) lauryl pyridinium chloride; and b) capryl hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, propanediol, benzoic acid, sodium benzoate, sorbic acid, sorbic acid Potassium, dehydroacetoic acid, sodium dehydroacetoate, propionic acid, sodium propionate, formic acid, sodium formate, hexamidine diisethionate, capryloylglycine, undecylenoylglycine, C12-C14 alkyldiaminoethylglycine HCL, lauryldiethylene One or more compounds selected from the group consisting of diaminoglycine, laurylaminopropylglycine, tropolone, and chlorphenesin can be included.

  The wet tissue composition is based on the total weight of the composition: a) lauryl pyridinium chloride 0.01-30 wt%; and b) capryl hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, Propanediol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetoate, propionic acid, sodium propionate, formic acid, sodium formate, hexamidine diisethionate, capryloylglycine, unde Selected from the group consisting of silenoylglycine, C12-C14 alkyldiaminoethylglycine HCL, lauryldiethylenediaminoglycine, laurylaminopropylglycine, tropolone, and chlorphenesin One or more compounds that may be those mixed in a proportion of 0.001 wt%. Preferably, a) 0.01 to 5% by weight of lauryl pyridinium chloride, and b) one or more compounds in a proportion of 0.005 to 5% by weight, more preferably a) lauryl pyridinium chloride 0.03%. -0.5 wt%, and b) one or more compounds in a proportion of 0.005-1 wt%.

  The lauryl pyridinium chloride has an excellent antibacterial effect against bacteria and fungi, and in particular, Staphylococcus aureus, Escherichia coli, Enterobacter hirae, Pseudomonas aeruginosa The antibacterial effect is excellent. In addition, it has low skin irritation, is suitable for wet tissue production that comes into direct contact with the skin, has good solubility in water, and has excellent diffusibility in the raw silk when applied to wet tissue, It can be easily applied during manufacturing.

  The laurylpyridinium chloride is a compound that can replace cetylpyridinium chloride, which is a preservative currently widely used, and a large amount of bubbles are generated due to the characteristics of cetylpyridinium chloride. Contamination in the process of adding antifoaming agent and sliminess of wet tissue, pop-up phenomenon (a phenomenon in which a large number of wet tissues are subsequently taken out when the wet tissue is pulled out), and difficulty in diffusion in the wet tissue base Can be overcome.

  The laurylpyridinium chloride can replace cetylpyridinium chloride, exhibiting antibacterial activity against Burkholderia cepacia that has acquired resistance to cetylpyridinium chloride.

  The content ratio of the lauryl pyridinium chloride may be 0.01 to 30% by weight based on the total weight of the wet tissue composition. If the proportion of the lauryl pyridinium chloride content is less than 0.01% by weight, the sterilizing power of the wet tissue composition does not reach the standard value of the sterilizing power as a reference when manufacturing the wet tissue, and exceeds 30% by weight. However, there is no great difference in sterilizing power, there is a limit of solubility at the time of dissolution, and additional additives and a heating step are required, which is not economical.

  The compounds can be mixed to increase the antibacterial effect of the lauryl pyridinium chloride, the compounds being hydroxamic acid and its salts, alkanediol, organic acid, hexamidine and the like Hexamidine and its salts, glycine, tropolone, and chlorphenesin can be included.

  The hydroxamic acid and salts thereof are capryl hydroxamic acid, biphenyl hydroxamic acid, and cinnamoyl hydroxamic acid, but are not limited thereto.

  The alkanediol is octanediol, hexanediol, or propanediol, but is not limited thereto.

  The organic acid is benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetoate, propionic acid, sodium propionate, formic acid, sodium formate, but is not limited thereto. .

  The hexamidine and salts thereof are hexamidine diisethionate, but are not limited thereto.

  Examples of the glycines include capryloyl glycine, undecylenoyl glycine, C12-C14 alkyl diaminoethyl glycine HCL, lauryl diethylene diamino glycine, and lauryl aminopropyl glycine, but are not limited thereto.

  The content ratio of the compound is 0.001 to 40% by weight based on the total weight of the wet tissue composition and less than 0.001% by weight. This is not preferable because the sterilizing power does not vary greatly even if it exceeds 40% by weight, which is uneconomical.

  The wet tissue composition comprises lauryl pyridinium chloride and capryl hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, propanediol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid , Sodium dehydroacetoate, propionic acid, sodium propionate, formic acid, sodium formate, hexamidine diisethionate, capryloyl glycine, undecylenoyl glycine, C12-C14 alkyl diaminoethyl glycine HCL, lauryl diethylene diamino glycine, lauryl amino The weight of one or more compounds selected from the group consisting of propylglycine, tropolone, and chlorphenesin is from 1: 4000 to 10: 1. It may be those mixed in a total. The weight ratio is preferably 1: 100 to 10: 1, and more preferably 1:10 to 10: 1.

  The diffusibility means the extent to which the wet tissue composition is absorbed and spread in the wet tissue base, and if the diffusibility is low, the preservative composition does not spread evenly in the wet tissue base. Microorganisms may grow in areas that do not contain the composition, which may cause strange odors, discoloration, and skin problems due to microbial by-products.

  The wet tissue composition has an excellent bactericidal and fungicidal effect, in particular, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterobacter hirae, black mold ( The best bactericidal effect on Aspergillus brasiliensis, Candida albicans, Mycobacterium terrae, and Burkholderia cepacia.

  The wet tissue composition can be used as it is or diluted with purified water.

  The wet tissue composition may be diluted 1 to 1000 times based on the total weight of the diluent, but this may vary depending on the judgment of those skilled in the art.

  The wet tissue composition comprises the lauryl pyridinium chloride and capryl hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, propanediol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetate Acid, sodium dehydroacetoate, propionic acid, sodium propionate, formic acid, sodium formate, hexamidine diisethionate, capryloylglycine, undecylenoylglycine, C12-C14 alkyldiaminoethylglycine HCL, lauryldiethylenediaminoglycine, lauryl In addition to one or more compounds selected from the group consisting of aminopropyl glycine, tropolone, and chlorphenesine, It can be.

  Examples of the additive include a moisturizer, a pH regulator, a thickener, a stabilizer, a perfume, a dispersant, and a coloring substance. Of these, humectants and pH adjusters are preferred.

  Examples of the humectant include propylene glycol, hexylene glycol, butylene glycol, glycerin, and methylpropanediol, preferably propylene glycol, Xylene glycol and butylene glycol are not limited thereto.

  The pH adjuster is citric acid, sodium citrate, EDTA (Ethylenediaminetetraacetic acid) -2NA, EDTA-4NA, KOH, etc., preferably citric acid, EDTA-2NA, However, the present invention is not limited to this.

  The present invention also relates to a wet tissue containing the wet tissue composition.

  The wet tissue includes 0.01 to 30% by weight of lauryl pyridinium chloride in a wet tissue raw material, and capryl hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, propanediol, benzoic acid, sodium benzoate Sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetoate, propionic acid, sodium propionate, formic acid, sodium formate, hexamidine diisethionate, capryloylglycine, undecylenoylglycine, C12-C14 alkyldiamino One or more selected from the group consisting of ethylglycine HCL, lauryldiethylenediaminoglycine, laurylaminopropylglycine, tropolone, and chlorphenesin Compound can be prepared by impregnating the wet tissue composition contains 0.001% by weight. Preferably, it can be produced by impregnating a wet tissue composition containing 0.01 to 5% by weight of laurylpyridinium chloride and 0.005 to 5% by weight of the one or more compounds, more preferably Can be prepared by impregnating a wet tissue composition containing 0.03 to 0.5% by weight of laurylpyridinium chloride and 0.005 to 1% by weight of the one or more compounds. May vary depending on the judgment of those skilled in the art.

  The wet tissue has an excellent bactericidal effect due to the inclusion of the wet tissue composition, and can reduce the wetness of the wet tissue and the pop-up phenomenon of the wet tissue.

  The wet tissue includes the wet tissue composition, and may include all wet tissues manufactured by a known manufacturing method existing in the art.

  The present invention relates to a wet tissue composition having increased diffusibility containing laurylpyridinium chloride as a main component and a wet tissue containing the same, and more particularly, lauryl pyridinium chloride, hydroxamic acid and salts thereof, Wet tissue composition with increased diffusibility comprising one or more compounds selected from the group consisting of alkanediol, organic acid, hexamidine and its salts, glycines, tropolone and chlorphenesin, and wet tissue containing the same About.

  It was confirmed that the wet tissue composition had excellent bacteria and fungicidal sterilization power, excellent wet tissue diffusibility, easy wet tissue production, and excellent quality of the produced wet tissue.

  Through this, the wet tissue composition having increased diffusibility containing laurylpyridinium chloride as a main component of the present invention can be replaced with an existing preservative composition containing cetylpyridinium chloride.

Photo of the results of confirming the antibacterial activity of the wet tissue composition of the present invention against bacteria, fungi, and Burkholderia

  Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein, and may be embodied in other forms. It should be noted that the contents introduced here are thorough and complete, and are provided to fully convey the idea of the present invention to those skilled in the art.

<Example 1. Production of Wet Tissue Composition Containing Laurylpyridinium Chloride and One Compound>
A wet tissue composition comprising lauryl pyridinium chloride of the present invention containing lauryl pyridinium chloride and one compound as a main component is produced. At this time, substances corresponding to the components and contents in the following <Table 1> are used in purified water. It was mixed and manufactured.

<Example 2. Production of Wet Tissue Composition Containing Laurylpyridinium Chloride and Two Compounds>
A wet tissue composition comprising lauryl pyridinium chloride of the present invention containing lauryl pyridinium chloride and two kinds of compounds as a main component is produced. At this time, substances corresponding to the components and contents in the following <Table 2> are used in purified water. It was mixed and manufactured.

<Example 3. Production of Wet Tissue Composition Containing Laurylpyridinium Chloride and Three or More Compounds>
A wet tissue composition mainly comprising lauryl pyridinium chloride of the present invention containing lauryl pyridinium chloride and three or more compounds is produced. At this time, a substance corresponding to the components and contents in the following <Table 3> is purified water. And mixed to produce.

<Comparative Examples 1 to 21. Manufacture of wet tissue composition for comparison>
Substances corresponding to the components and contents of <Table 4> below were placed in purified water and mixed to prepare a wet tissue composition for comparison.

<Experimental Example 1. Confirmation of antibacterial activity of wet tissue composition>
The antibacterial activity was confirmed using the wet tissue compositions of Examples 1 to 3 and Comparative Example. At this time, the bacteria were Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa ( Antifungal activity was confirmed using fungi and fungi mixed with Pseudomonas aeruginosa and fungi mixed with black mold (Aspergillus brasiliensis), fungi mixed with Candida albicans, and Burkholderia cepacia.

The antibacterial activity experiment was performed according to US Pharmacopoeia standards. Specifically, in order to confirm the decrease and killing rate of the bacteria, an experiment was conducted by a plate culture method, and the wet tissue composition was mixed with a bacterial mixture (bacteria 10 ⁶ to 10 ⁷ CFU / ml, fungus 10 ⁵ to 10 ⁶ CFU / ml). ml, Burkholderia 10 < ⁶ > to 10 < ⁷ > CFU / ml), and applied to a plate medium, then bacteria are 30-35 [deg.] C. for 24 hours, fungi are 25 [deg.] C. for 72 hours, Burkholderia is 30 The cells were cultured at ˜35 ° C. for 48 hours. At this time, a bacterial mixture not treated with the wet tissue composition was used for the control group. After culturing each bacterium, the number of colonies of the bacterium produced on the plate medium was counted, and then the mortality of the bacterium was calculated using the following <Equation 1>. And shown in FIG.

<Formula 1>
Bacterial death rate = ((number of inoculated bacteria in control group−number of remaining bacteria in wet tissue) / number of inoculated bacteria in control group) × 100

  The standard of the kill rate of the bacteria that can be used in the wet tissue composition is 99.9% or more, and if it is less than 99.9%, it is not suitable for wet tissue production.

  As shown in FIG. 1 and <Table 5>, in the case of the wet tissue compositions of Examples 1 to 3, the bacterial killing rate against bacteria, fungi, and Burkholderia was 99.9% or more, In the case where only one each of lauryl pyridinium chloride and compound is included as in Comparative Examples 1 to 8, or the content of lauryl pyridinium chloride and compound as in Comparative Example 9 and Comparative Example 10 is greater than the content of the present invention. When it was contained at a low level, it was confirmed that the killing rate against bacteria, fungi, and Burkholderia was less than 99.9%.

  In the case of a wet tissue composition (Comparative Example 12 to Comparative Example 21) containing cetylpyridinium chloride instead of laurylpyridinium chloride of the present invention, some compositions (Comparative Example 12, Comparative Example 14, Comparative Example) 16, Comparative Example 17 and Comparative Example 19) have a bacterial kill rate of less than 99.9% against Burkholderia, so that there are those that do not exceed the standard value as a wet tissue composition, and the bacterial kill rate is higher than the standard value. Even so, it was found that the diffusibility in the raw material diffusibility of Experimental Example 2 below was low, and there was a limit point when used in the wet tissue composition.

  Through this, in the case of the wet tissue composition containing the lauryl pyridinium chloride of the present invention as a main component, the fungus killing rate against bacteria, fungi, and Burkholderia is high, and in particular, the cetyl pyridinium chloride currently used mainly. Compared with this, it can be seen that the bacterium killing rate against Burkholderia is superior, so that it is expected to be used in a wet tissue composition that can replace cetylpyridinium chloride.

<Experimental example 2. Confirmation of diffusivity of wet tissue composition>
During the production of wet tissue, the wet tissue composition will be sown in the center of the wet tissue base, but if the diffusibility falls, there will be a problem that the edge of the raw tissue is not impregnated with the wet tissue composition, This provides an environment in which microorganisms can grow and can cause wet tissue contamination. Therefore, there is a complaint that an additional nozzle is installed on both sides of the wet tissue base during the process of manufacturing the wet tissue using a low diffusive wet tissue composition, which leads to consumption of the wet tissue composition. The amount also increases.

  The criteria for the diffusing power of the wet tissue composition is that 0.5 ml or 1 ml of the wet tissue composition is dropped on the wet tissue base having a diameter of 10 cm and left in the center of the raw base for 1 hour, and then the diffused diameter is measured. The size was measured. At this time, when the diameter of the wet tissue composition diffused is 0.5 ml when the wet tissue composition is dropped, the average is 3.0 cm or more, and when 1 ml is dropped, the average size is 6.0 cm or more. Since the wet tissue composition can be sufficiently impregnated to the edge of the wet tissue at the time of manufacturing the wet tissue, it can be determined that the diffusibility of the wet tissue composition is excellent based on this.

  Thereby, the diffusibility in the wet tissue raw material was confirmed using the wet tissue compositions of Examples 1 to 3 and Comparative Example.

  Each wet tissue composition 0.5ml or 1ml is dropped into a non-woven fabric mixed with rayon and polyethylene mainly used in wet tissue base at a ratio of 6: 4, and the size of the absorbed diameter is measured. Table 6> shows.

  As shown in <Table 6>, the lauryl pyridinium of the present invention is used as in Examples 1 to 3 as compared with wet tissue compositions containing cetyl pyridinium chloride as in Comparative Examples 12 to 21. It was found that the wet tissue composition containing chloride as a main component has a wide diffusion range in the wet tissue base.

  In addition, it was confirmed that as the total weight percent of laurylpyridinium chloride and compound increased, the diffusivity decreased somewhat due to the high content of laurylpyridinium chloride and compound. However, instead of laurylpyridinium chloride, the same weight percent of cetylpyridinium chloride was added It was confirmed that the wet tissue composition containing lauryl pyridinium chloride had higher diffusibility when compared with the case of containing.

  Furthermore, in the case of the wet tissue compositions of Comparative Examples 2 to 10, the diffusibility in the raw silkworm is high, but the antibacterial activity result of the wet tissue composition of Experimental Example 1 shows that the wet tissue composition It has been found that it is below the baseline value of antimicrobial activity that can be used and is not suitable for wet tissue compositions.

  Through this, it was found that the wet tissue composition containing laurylpyridinium chloride of the present invention as a main component has excellent diffusibility and can be easily used for wet tissue production.

  Through the results of Experimental Example 1 and Experimental Example 2, the wet tissue composition containing laurylpyridinium chloride of the present invention as a main component is more effective than the cetylpyridinium chloride currently used, and the fungal killing rate and the wet tissue raw material. It can be seen that the wet tissue composition is excellent in diffusibility and can replace cetylpyridinium chloride.

<Experimental Example 3. Confirming antibacterial activity according to diffusibility of wet tissue composition>
Experiments were conducted to compare antifungal activity according to the diffusibility of the wet tissue compositions of Examples 1 to 3 and Comparative Example.

  Comparative Example 13 and Comparative Example 20 containing cetylpyridinium chloride instead of the wet tissue compositions of Example 1-2, Example 2-1 and Example 3-1, and lauryl pyridinium chloride of Example, And the wet tissue raw material (nonwoven fabric in which rayon and polyethylene are mixed in a ratio of 6: 4) slid onto the wet tissue composition of Comparative Example 21 is 2.5 times the weight of the original raw material at the center portion on the top of the five sheets. After pouring the position, an article weighing about 5 kg was placed for 1 hour. Thereafter, the antibacterial activity was confirmed using the first and last wet tissue sheets.

  The first and last wet tissue stocks were placed in 100 ml of sterilized physiological saline to sufficiently swell the wet tissue composition, and then the same as in Experimental Example 2 using the swelled wet tissue composition. If the mortality rate of the bacteria is 99.9% or more, antibacterial activity is present, and if it is less than 99.9%, there is no antibacterial activity. The results are shown in Table 7.

  As can be seen from <Table 7>, in the case of the wet tissue compositions of Example 1-2, Example 2-1, and Example 3-1, all of the first and last wet tissue sheets were used. While the antibacterial effect exceeds the usable standard value of the wet tissue composition, the wet tissue composition containing cetylpyridinium chloride as a main component as in the wet tissue compositions of Comparative Example 13, Comparative Example 20, and Comparative Example 21 In this case, it was confirmed that the antibacterial effect of the last sheet of the wet tissue base did not exceed the usable standard value of the wet tissue composition, which was the wet tissue composition of Comparative Example 13, Comparative Example 20, and Comparative Example 21. It was expected that the diffusibility of the material in the raw wet tissue was low and not fully impregnated until the last sheet.

  As a result, it has been found that the wet tissue composition containing laurylpyridinium chloride of the present invention as a main component can replace the wet tissue composition containing cetylpyridinium chloride which has been mainly used.

<Production Example 1. Production of Wet Tissue Containing Invention Wet Tissue Composition>
The wet tissue compositions of Examples 1 to 3 and Comparative Example were impregnated into 80 wet tissue stocks for each wet tissue composition to produce wet tissue products.

<Experimental Example 4. Confirming antibacterial activity of wet tissue>
Antibacterial activity was confirmed using the wet tissue produced in Production Example 1.

  One wet tissue is placed in 100 ml of sterilized physiological saline to sufficiently swell the wet tissue composition, and then the experiment is performed by the same method as in Experimental Example 2 using the swelled wet tissue composition. The fungus kill rate is confirmed, and if the fungus kill rate is 99.9% or more, it is determined that there is antifungal activity, and if it is less than 99.9%, it is determined that there is no antifungal activity. The results are shown in <Table 8>.

  As shown in the above <Table 8>, in the case of the wet tissue manufactured with the wet tissue composition of Example 1 to Example 3, the antibacterial effect on bacteria, fungi, and Burkholderia all exceeded the standard value, When only one lauryl pyridinium chloride and a compound are included as in Comparative Examples 1 to 8, or the content of lauryl pyridinium chloride and a compound is lower than the content of the present invention as in Comparative Examples 9 and 10. When included, it was confirmed that some antibacterial activities against bacteria, fungi, and Burkholderia were less than the standard values. In addition, in the case of the wet tissue compositions of Comparative Examples 12 to 21 containing cetylpyridinium chloride instead of laurylpyridinium chloride of the present invention, the bacterial killing rate against Burkholderia may not exceed the standard value. I understood.

  Through this, it was found that the wet tissue produced using the wet tissue composition containing laurylpyridinium chloride as the main component of the present invention has excellent antibacterial activity.

<Experimental Example 5. Check physical properties of wet tissue>
Using the wet tissue produced in Production Example 1, physical properties such as a wet tissue pop-up phenomenon and sliminess were confirmed.

  In the case of the pop-up phenomenon, the wet tissue is pulled out with the same force and speed, and the number of times when two or more sheets are pulled out at a time in the process of pulling out is measured, and the result is shown in <Table 9>.

  As shown in <Table 9>, in the case of wet tissues manufactured using a wet tissue composition containing lauryl pyridinium chloride as a main component as in Examples 1 to 3, Comparative Examples 13 to 21 Thus, it was confirmed that the pop-up phenomenon occurred less than the wet tissue manufactured using the wet tissue composition containing cetylpyridinium chloride as a main component.

  In addition, even in the case where the wet tissue is slimy and bubbles are generated, the wet tissue produced using the wet tissue composition containing lauryl pyridinium chloride as a main component of the present invention contains cetyl pyridinium chloride as a main component. It was confirmed that there was little sliminess and low bubble generation compared to the wet tissue produced with the use of.

  Through this, it was found that the quality of the wet tissue manufactured with the wet tissue composition containing lauryl pyridinium chloride of the present invention as a main component was excellent.

Claims (8)

a) Laurylpyridinium chloride 0.01% to less than 5% by weight ;
b) Caprylhydroxamic acid, Biphenylhydroxamic acid, Cinnamoylhydroxamic acid, Octanediol, Hexanediol, Propanediol, Benzoic acid ), Sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetic acid, propionic acid, Sodium propionate, formic acid, sodium formate, hexamidine diisethionate, capryloyl glycine, undecylenoyl glycine C12-C14 alkyl diaminoethyl glycine HCl, Lauryl diethylene diamino glycine, Lauryl aminopropyl glycine, Tropolone, and Chlorphenesin 1) one or more compounds selected from the group consisting of 0.005 and less than 5% by weight . A wet tissue composition having increased diffusibility in a wet tissue stock. The wet tissue composition is
a) Laurylpyridinium chloride 0.03 or more and less than 0.5 % by weight;
b) capryl hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, propanediol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetoate, propionic acid, Sodium propionate, formic acid, sodium formate, hexamidine diisethionate, capryloyl glycine, undecylenoyl glycine, C12-C14 alkyl diaminoethyl glycine HCL, lauryl diethylene diamino glycine, lauryl aminopropyl glycine, tropolone and chlorphenesin 2 or more and less than 1 % by weight of at least one compound selected from the group consisting of: Wet tissue composition. The wet tissue composition is
Lauryl pyridinium chloride and capryl hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, propanediol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetoate, propion Acid, sodium propionate, formic acid, sodium formate, hexamidine diisethionate, capryloyl glycine, undecylenoyl glycine, C12-C14 alkyl diaminoethyl glycine HCL, lauryl diethylene diamino glycine, lauryl aminopropyl glycine, tropolone, and chlor 2. One or more compounds selected from the group consisting of phenesin are mixed in a weight ratio of 1:10 to 10: 1. Or a wet tissue composition having increased diffusibility in the wet tissue base as described in 2. The compounds are caprylic hydroxamic acid, biphenyl hydroxamic acid, cinnamoyl hydroxamic acid, octanediol, hexanediol, propanediol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetoate, propion It is an acid, sodium propionate, formic acid, sodium formate, The wet tissue composition with which the diffusibility in the wet tissue raw material of Claim 1 or 2 increased. 5. The wet tissue composition with increased diffusibility in a wet tissue stock according to claim 4, wherein the compound is capryl hydroxamic acid, biphenyl hydroxamic acid, and cinnamoyl hydroxamic acid. The wet tissue composition according to claim 1 or 2, wherein the wet tissue composition further includes a humectant and a pH adjuster. The wet tissue composition comprises Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterobacter hirae, Aspergillus brasiliensis, Candida albicans ), Mycobacterium terrae, and Burkholderia cepacia have a bactericidal power. The wet tissue composition having increased diffusibility in a wet tissue stock according to claim 1 or 2. A wet tissue comprising the wet tissue composition according to claim 1 or 2.

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