KR20170003373A - antiseptic Wet wipes compositions and wet wipes containing the same - Google Patents

Abstract

The present invention relates to an antiseptic composition for moist towelettes and moist towelettes comprising the same, and more specifically, to an antiseptic composition for moist towelettes comprising one or two or more kinds of a) hexamidine diisethionate, or b) dibromohexamidine diisethionate. The moist towelettes prepared according to the present invention, by comprising one or two or more kinds of hexamidine diisethionate or dibromohexamidine diisethionate, shows excellent antiseptic effects against various microorganisms generated during the manufacturing process for moist towelettes. Also, by significantly reducing or completely eliminating the use of quaternary ammoniums such as cetylpyridinium chloride, the present invention can reduce foaming and the occurrence of pop-up problems when using the moist towelettes. Further, the present invention can significantly improve upon problems of dispersion and slimy feel that are typical of conventional moist towelettes produced using antiseptic compositions containing cetylpyridinium chloride.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a wet tissue preservative composition and antiseptic wet wipes compositions and wet wipes containing the same,

The present invention relates to a wet tissue preservative composition and a wet tissue including the same, and more particularly, to a wet tissue preservative composition comprising: a) 0.0001 to 20% by weight of ethyl lauroyl ajinate hydrochloride; b) 0.001 to 10% by weight of hexamedine diisethionate; and c ) Purified water in an amount of 30 to 99.99% by weight, wherein the composition has an antibacterial effect on Burkholderia sp., Which is spread by a wet tissue, and a wet tissue including the same.

Wet tissue refers to a nonwoven fabric (natural pulp, cotton, tencel, natural fiber fabric, nonwoven fabric, synthetic fiber fabric, blend fabric, etc.) that is used to clean the human body. Due to its portability and ease of use, demand for wet tissues is increasing rapidly.

Types of wipes are classified into various types such as oral wet wipes, infant wet wipes, women's wet wipes, sanitary wet wipes, and multi-purpose wet wipes. This product is not a product that is rinsed with water after one use. Therefore, there is a possibility that the preservative contained in the product may remain on the skin, and the use area of the product is sensitive to chemicals such as mouth or hands. It is less irritating to the skin because of direct contact with the skin of the human body, has excellent safety, and has excellent removability against foreign substances and pathogenic microorganisms remaining on the skin.

Cetylpyridinium chloride (CPC), which is the most widely used quaternary ammonia type currently used as a wetting preservative, increases defoaming amount over time and should be used as defoaming agent. In this case, contamination and process trouble It represents various problems. Also, there is a variety of problems such as slippery, a phenomenon in which the popup phenomenon of the wet tissue is increased, and diffusion in the wet tissue is poor and the microorganism is vulnerable to contamination. In addition, during the manufacturing process of the wet tissue, various bacteria are proliferated. Among them, Burkholderia sp. Is infected with the wet tissue by the wet tissue manufacturing facility. Therefore, it is urgent to develop a new preservative for wet tissues that significantly reduces or completely replaces the usage of such quaternary ammonium-based materials such as cetylpyridinium chloride.

As a new wetting agent preservative that significantly reduces or completely replaces the amount of cetylpyridinium chloride is used, the amount of cream barazole, which is often used as a preservative in domestic and overseas cosmetics, is increasing. Climbazole, which is used as a wet tissue preservative, is a white crystalline powder. It is known to be 0 grade in the EWG Skin Deep grades, a non-profit environmental research institute in the US, and has lower irritancy and lower risk than other ingredients. Creambarzole is also known to have an exclusive and persistent germicidal effect on ovarian fungi and tricobacillus, but it is not soluble in water and is a potentially toxic harmful substance.

Gram-negative bacilli are a major cause of hospital infection, and the extent and extent of resistance has recently become more severe, making the choice of empirical antibiotics more difficult. Especially, Gram negative bacillus isolated from Korea is remarkably high in resistance against commonly used antibiotics, and recently, Gram negative bacillus showing resistance to multidrug resistance has also been expanded.

Hexamidine diisethionate (HEXM) is mainly used for oral disinfection, and it is also a safe substance that can be used in cosmetics because it is also registered in the International Cosmetic Ingredient Dictionary (ICID), but it is not known if it is applied to wet tissues.

Dibromohexamidine diisethionate (dHEXM) has also been used as a preservative for a long time and is also a safe substance that can be used in cosmetics because it is also registered in the International Cosmetic Ingredient Dictionary (ICID), but it is not known if it is applied to wet tissues.

Korean Patent Publication No. 10-1525987 (a wet tissue composition and a wet tissue including the same) of the present invention relates to the production of a wet tissue composition containing ethyllauryl alginate hydrochloride. However, the antifungal activity is insufficient, there was.

KR 10-1525987 B1 (2015.05.29)

In order to solve the above problems, the present invention provides a wet tissue preservative composition comprising at least one of hexamethine diisethionate or dibromohexamedine diisethionate, Which is capable of replacing the wet tissue preservative composition of the present invention.

It is another object of the present invention to provide a wet tissue preservative composition using one or more of hexamethine diisethionate or dibromohexamethine diisethionate to exhibit resistance to bacteria and fungi.

In order to achieve the above object, the wet tissue preservative composition according to the present invention comprises a) 0.0001 to 20% by weight of ethyllauryl azide hydrochloride, b) 0.001 to 10% by weight of hexamedine diisethionate, and c) Wherein the composition has an antibacterial effect on Burkholderia sp. Which is spread by a wet tissue.

The wet tissue preservative composition may further include one or more of glycols, organic acids or glycines.

The wet tissue produced according to the present invention may be prepared by mixing one or more of hexamethine diisethionate or dibromohexamedine diisethionate to prepare a wet tissue preservative composition, It has the advantage of excellent preservative effect.

Further, the wipes composition according to the present invention significantly reduces or completely eliminates the use amount of quaternary ammonium such as cetylpyridinium chloride chloride, thereby reducing the amount of foaming of the wet tissue and significantly reducing the occurrence of pop-up phenomenon.

Also, there is an effect that the problem of slipperiness and diffusibility which have occurred in the wet tissue produced by using the preservative composition for wet tissues containing cetylpyridinium chloride chloride is remarkably improved.

The present invention relates to a wet tissue preservative composition and a wet tissue containing the same.

The inventors of the present invention have made extensive efforts to develop a wet tissue preservative composition having excellent germicidal effect and a wet tissue including the same, and as a result, they have found a wet tissue composition according to the present invention.

The wet tissue preservative composition according to the present invention comprises: a) 0.0001 to 20% by weight of ethyllauryl azide hydrochloride; b) 0.001 to 10% by weight of hexamethine diisethionate; and c) 30 to 99.99% by weight of purified water Preferably, the composition has an antibacterial effect on Burkholderia sp., Which is spread by a wet tissue.

Further, the wet tissue preservative composition preferably further comprises one or more of glycols, organic acids, or glycines.

Also, the wet tissue containing the wet tissue preservative composition is preferably a wet tissue.

The glycols contained in the wet tissue preservative composition may be one or more selected from the group consisting of octanediol, hexanediol, caprylyl glycoll, glyceryl caprylate, and ethylhexyl glycerin. And it is preferable that it contains 0.0001 to 20% by weight of one or more kinds of glycols composed of octanediol, hexanediol, caprylyl glycols, glyceryl caprylate or ethylhexyl glycerin.

In addition, the organic acids contained in the wet tissue preservative composition may include one or more organic acids composed of levulinic acid, p-anionic acid, or sodium dehydroacetate, It is preferable to include 0.0001 to 20% by weight of one or more kinds of organic acids composed of acide, p-anisoacid or sodium dehydroacetate.

The glycine to be contained in the wet tissue preservative composition may include one or more glycines selected from undecylenoyl glycine or capryloyl glycine, and the undecylenoyl glycine or glycine And 0.0001 to 20% by weight of one or more glycines composed of capryloylglycine.

When the wet tissue composition is prepared at less than the content of each of the wet tissue compositions, the effect of the wet tissue composition is insufficient, which may cause the growth of microorganisms, which is undesirable. , The difference in the effect of the wet tissue composition is not large, which is uneconomical and therefore undesirable.

The diluted ratio of the wet tissue preservative composition is preferably in the range of 98.9 to 99.7% by weight of distilled water or purified water of 0.3 to 1.1% by weight of the wet tissue preservative composition, To prepare a wet tissue liquid, and then to prepare a wet tissue including the wet tissue liquid. More preferably, a wet tissue liquid is prepared by mixing 99.6% by weight of purified water with 0.4% by weight of a wet tissue preservative composition.

The above-mentioned hexamidine diisethionate (HEXM) or dibromohexamethine diisethionate dibromohexamidine diisethionate (dHEXM) is a conventional cetylpyridine compound used in a preservative composition for a wet tissue, It is a preservative composition which can be used as a preservative composition by replacing quaternary ammonium-based materials such as sodium chloride, and is a preservative composition capable of replacing the recently used cream barazole.

In addition, hexamethine diisethionate or dibromohexamethine diisethionate is a safe substance used for cosmetic use, but it is extremely rare when it is applied to a wet tissue.

Hexamidine diisethionate (HEXM) is mainly used for oral disinfection, and it is also a safe substance which can be used in cosmetics because it is also registered in International Cosmetic Ingredient Dictionary (ICID). However, it is not known that it is applied to wet tissues. The hexamedine diisethionate may be represented by the following general formula (1).

The dibromohexamidine diisethionate (dHEXM) has been used as a preservative for a long time and it is also a safe substance which can be used in cosmetics because it is also registered in the International Cosmetic Ingredient Dictionary (ICID). However, it is not known that it is applied to a wet tissue. The dibromohexamedine diisethionate may be represented by the following general formula (2).

The wet tissue composition prepared using the above materials may be prepared by mixing one or more of hexamidine diisethionate (HEXM) or dibromohexamedine diisethionate to prepare a wet tissue preservative composition It has an effect of improving the resistance to mold.

Also, by producing the wet tissue liquid using the above-mentioned materials, the antimicrobial effect is enhanced and the synergistic effect is imparted, thereby effectively suppressing major microorganisms such as fungi and bacteria.

Hereinafter, preferred embodiments, comparative examples, and experimental examples are provided to facilitate understanding of the present invention. It should be understood, however, that the following examples, comparative examples and experimental examples are provided only to facilitate understanding of the present invention, and that the present invention is not limited to the following examples, comparative examples and experimental examples.

Experimental Example 1: Microbial minimum inhibitory concentration

The antimicrobial effect of each substance used in the present invention on bacteria and fungi was measured by MIC (Minimum inhibition concentration: 2-fold dilution method) and the results are shown in Table 1 below. A test organism is Staphylococcus aureus (Staphylococcus aureus), Pseudomonas aeruginosa (Pseudomonas aeruginosa), E. coli (Escherichia coli), Candida albicans (Candida albicans , Burkholderia cepacia and Aspergillus niger were tested.

Minimum inhibitory concentration (MIC) Staphylococcus P. aeruginosa Escherichia coli Candida
Albikans Burg Helderia Sepassia Black mold Hexamethine
Diisethionate 80 40 20 20 10 10 Dibromohexamidine
Diisethionate 80 40 40 40 20 20

Unit: ppm

Hexahydro medin diimide three Fuck carbonate or dibromo-hexahydro medin diimide three Fuck Nate staphylococci (Staphylococcus aureus) As shown in Table 1, Pseudomonas aeruginosa (Pseudomonas aeruginosa), E. coli (Escherichia The MIC values of E. coli and Candida albicans were 20 to 80 ppm and the antifungal activities of Burkholderia cepacia and Aspergillus niger were 10 to 20 ppm Can be confirmed.

As a result of Experimental Example 1, it was confirmed that hexamethine diisethionate or dibromohexamedine diisethionate could be contained in the wet tissue preservative solution to enhance the antimicrobial and antifungal effect of the wet tissue preservative solution and to give a synergistic effect .

Experimental Example 2: Preparation of a wet tissue preservative composition

The wet tissue preservative composition was prepared by mixing each composition as shown in the following Table 1, and then 0.4 wt% of the prepared wet tissue preservative composition was diluted to 99.6 wt% of distilled water.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Hexamedine diisethionate 3 wt% - 3 wt% - - - - - Dibromohexamedine diisethionate - 3 wt% - 3 wt% - - - - Hexylene glycol 5 wt% 5 wt% 5 wt% 5 wt% - 10 wt% 5 wt% 10 wt% Ethyl Lauroyl Alginate Hydrochloride - - 5 wt% 5 wt% - - 5 wt% - Cetylpyridinium chloride - - - - 15 wt% 10 wt% 15 wt% 10 wt% Caprylic clicol 5 wt% 5 wt% - - - 5 wt% - - Sodium benzoate - - 3 wt% 3 wt% 10 wt% - - 10 wt%

Example

Example 1

3% by weight of hexamidine diisethionate (HEXM), 5% by weight of hexylene glycol, 5% by weight of caprylyl glycol and 87% by weight of purified water To prepare a preservative composition for a wet tissue.

Example 2

3% by weight of dibromohexamidine diisethionate (dHEXM), 5% by weight of hexylene glycol, 5% by weight of caprylryl glycol and 87% by weight of purified water, To prepare a wet tissue preservative composition.

Example 3

3% by weight of hexamidine diisethionate (HEXM), 5% by weight of hexylene glycol, 5% by weight of ethyl lauroyl arginate HCl (LAE), sodium benzoate 3% by weight of sodium benzoate (SB) and 84% by weight of purified water to prepare a preservative composition for a wet tissue.

Example 4

3 wt% of dibromohexamidine diisethionate (dHEXM), 5 wt% of hexylene glycol, 5 wt% of ethyl lauroyl arginate HCl (LAE) , 3% by weight of sodium benzoate (SB) and 84% by weight of purified water, to prepare a preservative composition for a wet tissue.

Comparative Example

Comparative Example 1

15% by weight of cetyl pyridinium chloride, 10% by weight of sodium benzoate (SB) and 75% by weight of purified water were mixed to prepare a preservative composition for a wet tissue.

Comparative Example 2

10% by weight of cetyl pyridinium chloride, 10% by weight of hexylene glycol, 5% by weight of caprylryl glycol and 75% by weight of purified water, A preservative composition for a wet tissue was prepared.

Comparative Example 3

15% by weight of cetyl pyridinium chloride, 5% by weight of ethyl lauroyl arginate HCl (LAE), 5% by weight of hexylene glycol and 75% by weight of purified water, To prepare a wet tissue preservative composition.

Comparative Example 4

10% by weight of cetyl pyridinium chloride, 10% by weight of hexylene glycol, 10% by weight of sodium benzoate (SB) and 70% by weight of purified water, A preservative composition was prepared.

Experimental Example 3: Antibacterial and antifungal activity evaluation of a wet tissue preservative composition

The shaking flask method was used as a method for evaluating the antibacterial and antifungal test of the wet tissue preservative compositions according to Examples 1 to 4 and Comparative Examples 1 to 4.

It was placed in a specifically sterilizing wipes each one 100㎖ enough saline solution to elute the tissue, Staphylococcus aureus (Staphylococcus aureus), Pseudomonas aeruginosa (Pseudomonas aeruginosa), E. coli (Escherichia coli ), Candida albicans ( Candida albicans , Burkholderia cepacia), and the black mold (Aspergillus niger) for each 10 ⁵ to 10 ⁸ After CFU / ㎖ inoculation, and then counting the number of colonies to test the plate culture method to determine the reduction of the bacteria and the mortality rate was measured mortality rate .

Dead rate (reduction rate) = (number of control - number of samples) / number of control × 100

The results measured according to the above-mentioned mortality rate calculation equations are shown in Table 3 below.

division Staphylococcus P. aeruginosa Escherichia coli Candida
Albikans Burg Helderia Sepassia Black mold Example 1 99.9% 98.3% 99.9% 96.7% 93.1% 99.9% Example 2 99.9% 93.2% 99.9% 91.8% 90.5% 97.4% Example 3 92.4% 92.7% 96.2% 91.2% 91.8% 92.4% Example 4 92.6% 90.6% 95.3% 90.5% 90.3% 90.1% Comparative Example 1 75.5% 80.1% 75.2% 72.2% 0% 69.4% Comparative Example 2 76.4% 82.4% 81.4% 72.1% 0% 69.5% Comparative Example 3 80.2% 83.3% 85.3% 75.2% 0% 72.3% Comparative Example 4 82.9% 84.5% 86.1% 80.3% 0% 71.4%

As shown in Table 3, it can be seen that Comparative Examples 1 to 4 exhibited a significantly lower mortality than Examples 1 to 4 in antibacterial and antifungal activity.

In Examples 1 to 4, it was confirmed that the antiseptic effect against bacteria and fungi was excellent, and that the bacteria control effect against Burkholderia sp. Caused by the wet tissue manufacturing facility and spread to the wet tissue .

The content of the cetylpyridinium chloride chloride contained in Comparative Examples 1 to 4 was the same as that of the hexamethine diisethionate contained in Example 1 and Example 2 and the content of dibromohexaene contained in Example 3 and Example 4 But the antimicrobial and antifungal effect of Staphylococcus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, or Black mold, which can be propagated in the wipes used by consumers, is lower than that of mesine diisethionate.

Experimental Example 4: Measurement of bubble generation amount

The wet tissue liquid containing the wet tissue preservative compositions according to Examples 1 to 4 and Comparative Examples 1 to 4 was prepared and the present experiment was conducted.

The wet tissue solution was prepared by diluting 0.4% by weight of the wet tissue preservative compositions of Examples 1 to 4 and Comparative Examples 1 to 4 with purified water to prepare a wet tissue solution.

The wet tissue solution containing each of the preservative compositions prepared above was mixed into the mixer at 500 rpm for 1 minute and the amount of the remaining foam was measured after 5 minutes.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Bubble height
(Cm) 0.1 0.1 0.8 One 6.5 5.2 3.5 4.3 Foaming time (minutes) One One 5 7 30 25 20 25

As shown in Table 4, it can be seen that the bubble generation amount of Examples 1 to 4 was significantly smaller than that of Comparative Examples 1 to 4.

Also, it can be seen from Examples 1 to 4 that bubbles are not generated as much as possible in the process of manufacturing the wet tissue.

Experimental Example 5: Measurement of the number of occurrences of pop-up phenomenon

The wet tissue liquid containing the wet tissue preservative composition according to Examples 1 to 4 and Comparative Examples 1 to 4 was prepared and the present experiment was conducted.

The wet tissue solution was prepared by diluting 0.4% by weight of the wet tissue preservative compositions of Examples 1 to 4 and Comparative Examples 1 to 4 with purified water to prepare a wet tissue solution.

Each of the wet tissues prepared as described above was impregnated with 100 pieces of fabric, and each wet tissue product was manufactured with the same. Then, the wet tissue was pulled out at the same speed as the same force. At the same time, , That is, the number of pop-up phenomena was measured. The experiment was repeated 10 times and the average value was recorded.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Number of popups - - - 2 60 40 20 48

As shown in Table 5, it can be seen that the pop-up phenomenon is remarkably reduced in the case of Examples 1 to 4 compared to the case of Comparative Examples 1 to 4. [

As a result of Table 5, it can be seen that the preservative composition for wet tissues of Examples 1 to 4 prepared according to the present invention is suitable for use in a wet tissue.

Experimental Example 6: Diffusion Force Measurement

The wet tissue liquid containing the wet tissue preservative compositions according to Examples 1 to 4 and Comparative Examples 1 to 4 was prepared and the present experiment was conducted.

The wet tissue solution was prepared by diluting 0.4% by weight of the wet tissue preservative compositions of Examples 1 to 4 and Comparative Examples 1 to 4 with purified water to prepare a wet tissue solution.

30 ml of each nonwoven fabric (15 cm x 15 cm) was stacked on each wettable liquid prepared as described above by dropping, and 2 ml of the solution was dropped in the center. After sealing for 5 minutes, the degree of diffusion was determined by the diffusion diameter Diffusion diameters of the bottom field were measured and compared. The experiment was repeated 10 times and the average value was recorded.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Top
Diameter (cm) 11.2 10.9 9.2 9.1 6.0 5.5 5.0 5.0 Bottom
Diameter (cm) 9.0 8.8 8.5 8.0 3.2 3.3 2.1 1.8

As shown in Table 6, it can be seen that the diffusing power of Examples 1 to 4 is higher than that of Comparative Examples 1 to 4.

As the spreading power is high, the amount of the solution used in the production of the wet tissue is significantly reduced, which is economical.

Experimental Example 7: Preservative composition safety

The safety test of the antiseptic composition for wet tissues according to Examples 1 to 4 and Comparative Examples 1 to 4 was conducted.

The composition containing each of the preservative compositions prepared above was allowed to stand in a 60 ° C incubator for 30 days to confirm the phase separation and physical properties of the composition.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Whether phase separation Not phase separated Not phase separated Not phase separated Not phase separated Phase separation Phase separation Phase separation Phase separation

As shown in Table 7, it can be seen that Examples 1 to 4 have higher preservative composition safety than Comparative Examples 1 to 4.

While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. Do.

Claims (2)

In the wet tissue preservative composition,
The wet tissue preservative composition
a) 0.0001 to 20% by weight of ethyl lauroyl anginate hydrochloride;
b) 0.001 to 10% by weight of hexamedine diisethionate; And
c) from 30 to 99.99% by weight of purified water,
Wherein the composition has an antibacterial effect on a Burkholderia sp. Strain infected with a wet tissue.
The method according to claim 1,
Wherein the wet tissue preservative composition further comprises one or more of glycols, organic acids, or glycines.