KR101856771B1 - Composition for moist towelette containing alkyl-PG-dimonium chloride - Google Patents

Composition for moist towelette containing alkyl-PG-dimonium chloride Download PDF

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KR101856771B1
KR101856771B1 KR1020150079214A KR20150079214A KR101856771B1 KR 101856771 B1 KR101856771 B1 KR 101856771B1 KR 1020150079214 A KR1020150079214 A KR 1020150079214A KR 20150079214 A KR20150079214 A KR 20150079214A KR 101856771 B1 KR101856771 B1 KR 101856771B1
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Prior art keywords
wet tissue
composition
dimonium chloride
alkyl
formula
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KR1020150079214A
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Korean (ko)
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KR20160143098A (en
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김태효
김나래
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주식회사 비제이바이오켐
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    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47K—SANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR; TOILET ACCESSORIES
    • A47K7/00—Body washing or cleaning implements
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47K—SANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR; TOILET ACCESSORIES
    • A47K10/00—Body-drying implements; Toilet paper; Holders therefor
    • A47K10/16—Paper towels; Toilet paper; Holders therefor
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D—TEXTILES; PAPER
    • D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
    • D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
    • D21H17/00—Non-fibrous material added to the pulp, characterised by its constitution; Paper-impregnating material characterised by its constitution
    • D21H17/03—Non-macromolecular organic compounds
    • D21H17/05—Non-macromolecular organic compounds containing elements other than carbon and hydrogen only
    • D21H17/11—Halides

Abstract

The present invention relates to a composition for a wet tissue containing alkyl-PG-dimonium chloride, and more particularly to a composition for a wet tissue exhibiting cleaning and microbial-preventing effects without using any other preservative.

Description

Composition for moist towelette containing alkyl-PG-dimonium chloride < RTI ID = 0.0 >

The present invention relates to a composition for a wet tissue containing alkyl-PG-dimonium chloride, and more particularly to a composition for a wet tissue exhibiting cleaning and microbial-preventing effects without using any other preservative.

Generally, the wet tissue corresponds to a disposable handkerchief formed by absorbing a wet tissue solution on a wet tissue such as a pulp or nonwoven fabric. The wet tissue is used not only for keeping hands and skin clean, , Furniture, tables, and so on. Especially, infants are more likely to contact face and skin, and they are the main means of wiping infant's play equipment. Therefore, the wet tissue should have excellent safety to skin, and it is easy to remove foreign matter or pathogenic microorganisms And should have excellent antimicrobial activity.

In general, a wet tissue contains various organic substances such as natural products, moisturizers, and extracts, and thus is a material capable of propagating microorganisms from the time of manufacture to the time of delivery to consumers, and during use by consumers. In order to suppress the growth of these microorganisms, various means such as drying, heating, sterilization, and individual aseptic packaging have been utilized. However, this is effective in preventing contamination up to the packaging stage. Recently, however, since the wipes are becoming large in quantity, and a large amount of wet tissue is continuously drawn or the products which are to be used for a long time after opening the package are often contaminated during use, Components that inhibit the growth of microorganisms should be essentially contained in the contamination.

To solve these problems, various preservatives which are economical and effective in small amounts have been used. Representative preservatives include isothiazolinone, parabens, imidazolidinyl urea, diazolidinyl urea, sodium benzoate, phenoxyethanol (Phenoxy Ethanol), diazolidinyl urea, Benzalkonium chloride, formaldehyde, etc. These ingredients strongly inhibit the growth of microorganisms, but at the same time, they cause harmful effects on the skin and harmful effects on the human body in the long term. . As a result, some ingredients may be regulated or limited in use. Especially, isothiazolinone is reported to have harmful results in domestic humidifier disinfectant, etc., and also there are controversy about safety at home and abroad, such as daazolydinyl urea and imazapyridinyl urea, which are known as formaldehyde lyerizers, . Even parabens, which are widely used in cosmetics and are known to be relatively safe, are becoming a problem of skin allergy, environmental problems, and resistant bacteria.

Recently, a safer microbial inhibitor replacing preservatives has been proposed as 1,2-Hexanediol, 1,2-Octanediol, Caprylyl Glycol, Ethylhexyl glycerin and the like are used in wet tissues. Although they have the advantage of being safer than conventional preservatives, most of the ingredients except 1,2-hexanediol are insoluble in water, so there are restrictions on their use. Particularly in the case of ethylhexyl glycerin, . In recent years, a variety of mixtures having increased water solubility have also been filed for the improvement of these problems. As a mixture thereof, Application No. 2011-0131086 discloses a technique for improving solubility through the mixing of ethylhexyl glycerin, caprylyl glycol and glycerin , Application No. 2013-0101775 discloses a mixture of caprylyl glyceryl ether, ethylhexyl glycerin and caprylyl glycol.

In addition, there is a patent (registration number KR-200406695) using olive, cinnamon, ginger, pine, gibbous spearmint, spearmint or the like (registration number KR 100824609) and grapefruit seed extract as natural products.

However, these patents are also accompanied by a problem of narrow antibacterial spectrum, excessive usage. 1,2-hexanediol is required to be used in an excess amount of 2% or more, and 1,2-octanediol, glyceryl caprylate, and ethylhexyl glycerin are low in solubility in water, An emulsifier or a solubilizing agent must be included in the solution, which eventually leads to an increase in the amount of chemical used. Sometimes, the emulsifier or solubilizer used at this time is a cause of irritation, and the problem is that these kinds of ingredients are difficult to control the fungus.

In addition, there is a problem that the natural preservatives are required to be used much more than the synthetic preservatives, and that they are not economical to use for general purpose wet tissues due to their high price.

DISCLOSURE OF THE INVENTION It is, therefore, an object of the present invention to provide a composition for a wet tissue capable of controlling microbial growth with a small amount of skin irritation, excellent solubility in water, We aim.

In order to solve the above problems, the inventors of the present invention have found that a coconut oil surfactant having no skin irritation is excellent in solubility in water and is easy to use, and can provide an effect of cleaning and microbial control simultaneously with a small amount of alkyl-PG-dimonium chloride The compound was found and applied to the wet tissue. This compound has a cation in the molecule and is excellent in the adsorption ability to the cellulose structure of the nonwoven fabric.

The present invention relates to a wet tissue comprising essentially an alkyl-PG-dimonium chloride (also referred to as "alkamidopropyl-PG-dimonium chloride") compound of formula 1, which originates from coconut oil or palm kernel oil, ≪ / RTI >

Figure 112015054049844-pat00001

In the above formula (1), R is at least one alkyl group selected from the group consisting of C 6 -C 18 alkyl, alkenyl, alkylamidopropyl, and hydroxyalkyl groups. That is, a mixture of at least two alkyl-PG-dimonium chloride having a single R group or alkyl-PG-dimonium chloride having various alkyl groups above may be used in the wet tissue.

The present invention essentially contains 0.01 wt% to 5.0 wt%, preferably 0.1 wt% to 1.0 wt% of the compound of Formula 1 as a composition for a wet tissue. The compound represented by the above-mentioned formula (1) may be a compound having a constituent such as 1,2-hexanediol, 1,2-octanediol, butylglycerin, hexylglycerin, octylglycerin, ethylhexyl glycerin, glyceryl caprylate Can be used in combination with the compound of the formula (1) to improve the performance thereof. By adding 0.01 to 5.0% by weight of the compound of the formula (1), water-insoluble 1,2-octanediol, hexylglycerin, octylglycerin, ethylhexylglycerin, The solubility in water such as water and the like can be increased.

The present invention also relates to a wet tissue containing the composition for a wet tissue.

The wet tissue according to the present invention exhibits antiseptic activity and antimicrobial activity without addition of an additional preservative or an antimicrobial agent, and skin side effects due to preservatives, antibacterial agents, and other disinfecting agents can be prevented. In the purified water, the alkyl-PG- Chloride chloride component. The alkyl-PG-dimonium chloride of Formula 1 may be used alone or in combination with other preservatives such as 1,2-hexanediol, 1,2-octanediol, butylglycerin, hexylglycerin, octylglycerin, ethylhexylglycerin Ethylhexyl glycerin, and glyceryl caprylate; or food preservatives such as sorbic acid, potassium sorbate, benzoic acid, sodium benzoate, lactic acid, and glycerin fatty acid esters, and preservatives such as propylene glycol, hexylene glycol, glycerin, Glycols, dipropylene glycol, and the like.

The wet tissue fabric is preferably made of pulp material or nonwoven fabric, but may also be made of a fiber material or a cotton mixture such as cotton, if necessary. The liquid composition for a wet tissue, which is added to a wet tissue, exhibits hygienic activity such as sterilization, antibacterial, and moisturizing at the time of skin contact while keeping the wet tissue absorbed in the wet tissue, To 3% by weight of a compound of formula 1, preferably 0.1% to 1.0% by weight, of an alkyl-PG-dimonium chloride compound.

As the auxiliary microbial control component, 1,2-octanediol, butylglycerin, hexylglycerin, octylglycerin, ethylhexyl glycerin, glyceryl caprylate and the like can be used in the wet tissue composition, Glycols such as glycerin, propylene glycol and dipropylene glycol may be used.

The present invention is characterized in that an alkyl-PG-dimonium chloride component represented by the general formula (1) is added as a wet tissue composition in place of a preservative, and it is possible to constitute a free-flowing product having antimicrobial activity without a preservative. It also has the advantage of being safe because it shows skin conditioning effect and decontamination effect at the same time. Even if it is sensitive to chemical components, it has less side effect when it is adsorbed to fiber because of less amount of elution with water.

1 shows the results of a test for maintaining the antibacterial activity of a lauryl PG-dimonium chloride composition.
Figure 2 shows the results of a test for maintaining the antibacterial activity of the cocamidopropyl PG-dimonium chloride composition.
3 shows the results of the test for maintaining the antibacterial activity of the 1,2-hexanediol composition.
4 shows the results of the test for maintaining the antibacterial activity of the 1,2-butanediol composition.
Fig. 5 shows the result of the test for maintaining the antibacterial activity of the 1,2-octanediol composition.
6 shows the results of the test for maintaining the antibacterial activity of the glyceryl caprylate composition.
Figure 7 is a parallel streak test test result of the microbial control composition.

Hereinafter, the configuration of the present invention will be described in more detail with reference to embodiments. The following examples are provided to illustrate the present invention and are intended to be illustrative of the invention so as to enable those skilled in the art to easily carry out the invention. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims, Do.

In order to examine the performance of the alkyl-PG-dimonium chloride component of the formula (1) applied to the composition for wet tissues according to the present invention, the comparison was made through the examples. Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger were used as the bacteria used in this study.

≪ Examples 1 to 5 >

The microbial control components were diluted according to the compositions of Examples 1 to 5 according to Table 1 below and then stirred at room temperature.

Example 1 Example 2 Example 3 Example 4 Example 5 Lauryl PG-dimonium chloride 0.5% 0.3% 0.3% Cocamidopropyl PG-dimonium chloride 0.5% Cocoyl PG-dimonium chloride 0.5% 1,2-hexanediol 1.0% 1,2-butylglycerin 1.0%

≪ Comparative Examples 1 to 4 >

The microbial control components were diluted according to the compositions of Comparative Examples 1 to 4 according to Table 2 below, and then stirred at room temperature. At this time, 1,2-octanediol and glyceryl caprylate having low solubility in water were first mixed with dipropylene glycol and diluted with water before dilution with water.

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 1,2-hexanediol 2.0% 1,2-butylglycerin 2.0% 1,2-octanediol 0.7% Glyceryl caprylate 0.7% Dipropylene glycol 2.0% 2.0%

≪ Test Example 1 >

The wet tissue compositions of Examples 1 to 5 were placed in a test tube and further added with 10 ml of water. The water-insoluble components were first added to the dipropylene glycol and then added.

10 ml of water was added to another test tube and 5 ml of each strain including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and fungus Aspergillus niger Were mixed and cultured to prepare a mixed solution. 0.1 ml each of the prepared test mixture was added to the test tubes prepared by diluting the compositions of Examples 1 to 5. Samples prepared as described above were immediately inoculated into NA (Nutrient agar) medium and PDA (Potato dextrose agar) medium, and cultured in an incubator at 30 ° C for 24 hours to measure initial number of bacteria.

The colonies were counted by inoculating the NA and PDA media in the same manner as described above and culturing in an incubator at 30 ° C for 24 hours, In the case of the composition for a wet tissue containing the alkyl-PG-dimonium chloride represented by the formula (1) of the present invention, 0.3% concentration was applied and the other components were applied at the commercial concentration. The test results are shown in Table 3 (results of antibacterial activity test).

Example 1 Example 2 Example 3 Example 4 Example 5 Initial cfu (cfu) Not measurable One day of politics (NA medium) <10 <10 <10 <10 <10 One-day politics (PDA badge) <10 <10 <10 <10 <10

As shown in Table 3, although the initial number of bacteria was not measurable for each group, the microorganism count was observed to be less than 10 in the whole composition containing lauryl PG-dimonium chloride or cocamidopropyl PG-dimonium chloride of the present invention, Was 99.99% or more.

&Lt; Test Example 2 >

For each of the compositions for wet tissues of Examples 1 and 2 and Comparative Examples 1 to 4, 10 ml of water was added to each of 5 test tubes and the composition for wet tissue was added. The water-insoluble components were first added to the dipropylene glycol and then added.

Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida Albicans and fungus Aspergillus niger were added to each of the five test tubes (about 10 &lt; 6 &gt; 10 7 cfu).

Bacteria were inoculated into NA (Nutrient agar) medium, and fungi were inoculated into PDA (Potato dextrose agar) medium and cultured in an incubator at 30 ° C for 24 hours. After the samples of the compositions for wet tissues, that is, the samples of the compositions of Examples 1 to 2 and Comparative Examples 1 to 4 were allowed to stand for 3 days, they were inoculated into the NA medium and the PDA medium in the same manner as above, And the number of colonies was measured. And the maintenance of the sterilizing power of the composition for wet tissue was confirmed in the same manner in units of 7 days, 14 days and 28 days.

At this time, the test concentrations were 0.3% and 0.3%, respectively, for the wet tissue composition of the present invention and the recommended concentrations for the other components were respectively applied.

The test results are shown in Figs. 1 to 6. 1 to 6, the compositions of the present invention, lauryl PG-dimonium chloride or cocamidopropyl PG-dimonium chloride, are commercially available products, such as 1,2-hexanediol, 1,2-octane Diol, butyl glycerin, glyceryl caprylate and the like, and it is confirmed that the continuous microbial reduction effect is also effective in a relatively short period of time.

<Test Example 3> Parallel streak test

Four kinds of compositions were diluted by the proportions as in Example 1, Comparative Example 1, Comparative Example 3, and Comparative Example 4, and added to the wet tissue so that the antiseptic composition contained 0.3% by weight in the wet tissue and then cut into strips, Were prepared. In addition, 10 ml of water is added to a test tube, 10 ml of water is added to a test tube, and a mixture of bacteria, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, which is a bacterium, and Candida albicans, which is a fungus, (About 10 &lt; 6 &gt; to 10 &lt; 7 &gt; cfu).

The bacterial mixed solution was applied to the NA medium three times so as to have a length of 60 mm at intervals of 10 mm, and the fungus mixture was inoculated into the PDA medium in the same manner. The above wet tissue specimen was gently placed on each surface of the medium to be inoculated, and gently pressed with a sterilizing rod, followed by incubation in an incubator at 30 ° C to observe microorganism death.

FIG. 7 shows the appearance of the medium after 24 hours of inoculation. In the NA medium inoculated with the bacterial mixed solution, no microbial low zone was formed, but the microbial low zone was not proliferated in the wet tissue specimen. In the PDA medium inoculated with the fungal mixture, And thus the flushing force of the composition for wet tissues according to the present invention can be confirmed.

As described above, the composition for a wet tissue of the present invention exhibits excellent antimicrobial effect against various microorganisms such as bacteria, yeast, fungus and the like, and the microbial inhibitory effect is continuously exhibited.

Claims (5)

A preservative composition for a wet tissue containing an alkyl-PG-dimonium chloride compound of the following formula (1).
&Lt; Formula 1 >
Figure 112017116295219-pat00002

(Wherein R in Formula 1 is at least one selected from the group consisting of alkyl, alkenyl, alkylamidopropyl, and hydroxyalkyl groups having from 6 to 18 carbon atoms).
The method according to claim 1,
Wherein the alkyl-PG-dimonium chloride compound of Formula 1 comprises 0.01% to 5.0% by weight of the alkyl-PG-dimonium chloride compound.
The method according to claim 1,
Wherein the composition is selected from the group consisting of 1,2-hexanediol, 1,2-octanediol, butylglycerin, hexylglycerin, octylglycerin, ethylhexyl glycerin, glyceryl caprylate, sorbic acid, potassium sorbate, Wherein the preservative composition further comprises at least one of sodium benzoate, lactic acid, and glycerin fatty acid ester.
The method according to claim 1,
-PG- alkyl dimonium chloride compound of the formula (1) Escherichia coli (Escherichia Coli), Staphylococcus aureus (Staphylococcus Aureus), Pseudomonas aeruginosa (Pseudomonas Aeruginosa), Candida (Candida Albicans), and black from the group consisting of Aspergillus (Aspergillus niger) Wherein the preservative composition has antiseptic activity against at least one strain selected.
A wet tissue containing the preservative composition for a wet tissue according to any one of claims 1 to 4.
KR1020150079214A 2015-06-04 2015-06-04 Composition for moist towelette containing alkyl-PG-dimonium chloride KR101856771B1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210059237A (en) * 2019-11-15 2021-05-25 (주)다사요윙윙 Cleaning tissue based on anti ammonia composition, and manufacturing method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102405175B1 (en) * 2021-11-30 2022-06-07 한국콜마주식회사 Antiseptic system with antiseptic synergistic effect

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210059237A (en) * 2019-11-15 2021-05-25 (주)다사요윙윙 Cleaning tissue based on anti ammonia composition, and manufacturing method thereof
KR102348332B1 (en) * 2019-11-15 2022-01-06 (주)다사요윙윙 Cleaning tissue based on anti ammonia composition, and manufacturing method thereof

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