KR102307746B1 - Wet tissue composition and wet tissue comprising the same - Google Patents

Abstract

The present invention relates to a wet wipe composition that is highly effective in killing bacteria, a species of fungi, a species of yeast, and Burkholderia sp., and a wet wipe comprising the same. The wet wipe of the present invention includes a composition having an antibacterial activity, thereby not being denatured when stored for prolonged periods and being harmless to the human body. When manufacturing a wet wipe using the wet wipe composition of the present invention, which has excellent storage stability, productivity is improved, so that a high quality wet wipe can be provided.

Description

Wet tissue composition and wet tissue comprising the same

The present invention relates to a wet tissue composition having an excellent killing rate of bacteria, one fungus, one yeast, and Burkholderia, and a wet tissue comprising the same.

Wet wipes are made by applying a liquid raw material to a fabric that is resistant to moisture, and are also called wet tissues.

These wet wipes are made of pulp or non-woven fabric, which is not easily decomposed despite containing moisture, as a material. At the same time, it is used to detoxify a human body or an object in direct contact with the human body.

In addition, chemical preservatives such as benzene series or carbamate series are mainly used for the disinfection, antibacterial and sterilization components of these wet tissues to prevent the propagation of bacteria and mold in the process of packaging, distribution and use, and to prevent evaporation of moisture for a long period of time. Propylene glycol, which is a moisture evaporation inhibitor, is also used to prevent it.

As described above, even if the amount of chemical preservatives used in wet tissues is less than the legally permitted standard amount, if used for a long time or used frequently or in a large amount at once, skin troubles, hormonal abnormalities, and allergic reactions are harmful to the human body. It has a harmful effect, and in particular, in the case of a child with delicate skin or a patient with a skin disease, it reacts more sensitively to the chemical preservative contained in the wet tissue.

Republic of Korea Patent Registration KR 10-1943522 Republic of Korea Patent Publication KR 10-2017-0014494

The technical problem to be achieved by the present invention is to prepare a composition for wet tissues having excellent antibacterial activity and little or no skin irritation and using the same.

However, the technical problem to be achieved by the present invention is not limited to the above-mentioned problems, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.

In order to solve the above problems, the present invention includes potassium benzoate (Potassium Benzoate) as an active ingredient, sodium anisate, ethylhexylglycerin (Ethylhexylglycerin), levulinic acid (Levulinic Acid), glyceryl caprylate (Glyceryl Caprylate), Caprylyl Glycol, Hexanediol, Pentanediol, Decanediol, Sodium Dehydroacetate, Tetrasodium EDTA ) and lauraminopropylene, and provides a composition for wet tissues, further comprising one or more compounds selected from the group consisting of amines.

In one embodiment of the present invention, the composition may contain 0.1 to 0.2 parts by weight of potassium benzoate.

In another embodiment of the present invention, the composition comprises 0.1 to 0.2 parts by weight of potassium benzoate, sodium anisate 0.5 parts by weight, ethylhexyl glycerin 0.15 parts by weight, levulinic acid 0.25 to 0.5 parts by weight, glyceryl car Prylate 0.125 parts by weight, caprylyl glycol 0.25 to 0.5 parts by weight, hexanediol 1 part by weight, pentanediol 1 part by weight, decanediol 0.01 parts by weight, sodium dehydroacetate 0.125 parts by weight, and tetrasodium EDTA 0.1 to It may further include one or more compounds selected from the group consisting of 0.15 parts by weight.

As another embodiment of the present invention, the composition may further include 0.01 parts by weight of lauraminopropylene and an amine-based composition. Lauraminopropylene and amine-based may be lauraminopropylene glycol, but is not limited thereto.

In another embodiment of the present invention, the composition may include 0.2 parts by weight of potassium benzoate, 0.2 to 0.25 parts by weight of levulinic acid, and 0.1 to 0.15 parts by weight of trasodium EDTA. have.

In another embodiment of the present invention, the composition comprises 0.2 parts by weight of potassium benzoate, 0.15 to 0.2 parts by weight of levulinic acid, 0.1 to 0.15 parts by weight of tetrasodium EDTA, and lauraminopropylene and an amine-based composition. 0.01 parts by weight.

The composition for wet wipes contains 7 types of bacteria (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogins, Krebsiella pneumoniae, Salmonella, Micrococcus luteus), 1 type of fungus (black mold), 1 type of yeast (Candida) albicans), the mortality rate of Burkholderiales may be 99.9% to 100%.

Tetrasodium EDI may be substituted with disodium EDI, and tetrasodium EDI is more preferable in the mixing of raw materials to be mixed with wet tissues, but is not limited thereto.

In the present invention, 7 species (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogins, Krebsiella pneumoniae, Salmonella, Micrococcus ruu Teus), 1 type of fungus (black mold), 1 type of yeast (Candida albicans), and Burkholderiales have a synergistic effect that reaches 100%.

In addition, the present invention provides a wet tissue impregnated with the composition. Impregnation of the composition may be performed by spraying the composition on fibers such as a general nonwoven fabric used for manufacturing wet tissues, or by supporting the fibers in the composition.

The wet tissue of the present invention, including the composition having antibacterial activity, is not denatured and harmless to the human body even when stored for a long period of time. There will be.

Hereinafter, the present invention will be described in detail.

<Example 1> Bacterial death rate measurement method

To check the antibacterial and antifungal properties of the wet tissue, 7 types of bacteria (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogins, Krebsiella pneumoniae, Salmonella, Micrococcus luteus), 1 type of fungus (black mold), The mortality rate of one yeast species (Candida albicans), Burkholderiales was investigated.

Specifically, the method of measuring the number of viable cells for the wet tissue composition was carried out by the plate culture method. In order to check the reduction and death rate of bacteria, the bacterial mixture is inoculated into the wet tissue composition, and the inoculated sample is stored in an incubator at 25-30° C. for more than 60 minutes. After that, the sample inoculated with the bacteria was applied to the plate medium, and the bacteria and Burkholderia were cultured at 30~35℃ for 48 hours, and the fungi and yeast at 20~25℃ for 120 hours. At this time, the inoculated bacterial mixture was 10 ⁵ ~ 10 ⁶ CFU/ml for ^{7 types of bacteria, 10 6} ~ 10 ^{7 CFU/ml for Burkholderia, and 10 5} ~ 10 ⁶ CFU/ml for 1 type of fungus and 1 type of yeast. , as a control, was carried out with a bacterial mixture that was not treated with the wet tissue composition.

After culturing each bacteria, the number of colonies of the bacteria was counted in the pyeonpan medium, and the survival inhibition rate of the bacteria was calculated to calculate the value.

Survival inhibition rate (death rate) = ((number of inoculated cells in control group - number of colonies in wet tissue composition)/number of inoculated cells in control) X 100

When the mortality value is 99.9% or more, it can be used as a wet tissue composition.

<Example 2> Analysis of wet tissue composition with antibacterial activity

<2-1> Analysis of primary antimicrobial substances and combinations

The present inventors have completed the present invention by intensively researching for the development of wet wipes with excellent antibacterial activity and little or no skin irritation.

Accordingly, potassium benzoate, sodium anisate, ethylhexylglycerin, levulinic acid, glyceryl caprylate, caprylyl glycol, hexanediol, pentanediol, decanediol, sodium dehydroacetate, and tetrasodium EDTA The antibacterial activity was confirmed by mixing by combination and content.

In the present invention, sodium anisate is widely used as an additive to control the pH of cosmetics and has a conditioning effect, and ethylhexylglycerin is a multi-purpose multifunctional additive that inhibits the growth of anaerobic bacteria and is a deodorant. is being used as In addition, levulinic acid, glyceryl caprylate, caprylyl glycol, hexanediol, pentanediol, decanediol, sodium dehydro Acetate (Sodium Dehydroacetate), and Tetrasodium EDTA (Tetrasodium EDTA) are commonly used as preservatives in cosmetics and are harmless to the human body and their safety is guaranteed. Therefore, as shown in Table 1 below, the present inventors have prepared potassium benzoate and sodium anisate, ethylhexyl glycerin, levulinic acid, glyceryl caprylate, caprylyl glycol, hexanediol, pentanediol, decanediol, sodium dehydroacetate, and One type of compound selected from the group consisting of tetrasodium EDTA was mixed with distilled water, and the survival inhibition rate of 7 types of bacteria, 1 type of fungus, 1 type of yeast, and Burkholderia was confirmed by the method of Example 1. .

As a result, as shown in Table 1 below, the mortality rate was 99.9% in all combinations, and in particular, when the content of potassium benzoate was 0.2% of the total weight and 0.25% of levulinic acid, 7 types of bacteria and 1 type of fungi, 1 type of yeast, and burke It was confirmed that the death rate of Holderia was 100%.

number Potassium Benzoate Sodium anisate Ethylhexylglycerin levulinic acid Glyceryl Caprylate caprylyl glycol hexanediol pentanediol Decanediol Sodium Dehydroacetate Tetrasodium EDITA Purified water 7 types of bacteria 1 type of fungus, 1 type of yeast Burkholderia weight(%) mortality to
100 99.9 99.9 99.9 1-1 0.125 One to
100 99.9 99.9 100 1-2 0.125 0.5 to
100 99.9 99.9 100 1-3 0.125 0.125 to
100 100 100 100 1-4 0.125 0.5 to
100 99.9 99.9 100 1-5 0.125 One 0.01 to
100 99.9 99.9 100 1-6 0.125 0.5 to
100 99.9 99.9 100 1-7 0.1 0.25 to
100 99.9 99.9 100 1-8 0.15 0.125 to
100 99.9 99.9 100 1-9 0.15 to
100 99.9 99.9 99.9 1-10 0.2 0.1 to
100 99.9 99.9 99.9 1-11 0.2 0.15 to
100 99.9 99.9 99.9 1-12 0.2 0.25 to
100 100 100 100

<2-2> Analysis of secondary antimicrobial substances and combinations

If the complete killing of microorganisms is not guaranteed, it is difficult to ensure safety for human use due to proliferation during the storage period of wet tissues. Therefore, for more complete bacterial control, the content of potassium benzoate is 0.2% of the total weight, and sodium anisate, ethylhexyl glycerin, levulinic acid, glyceryl caprylate, caprylyl glycol, hexanediol, pentanediol, By mixing the contents of two types of compounds selected from the group consisting of decanediol, sodium dehydroacetate, and tetrasodium EDTA as shown in Table 2 below, according to the method of Example 1, 7 types of bacteria and 1 type of fungus; One type of yeast and the survival inhibition rate of Burkholderia were confirmed.

As a result, as shown in Table 2 below, all exhibited high antibacterial activity, and in particular, 7 in the compositions (2-1 to 2-3) containing a mixture of potassium benzoate, levulinic acid, and tetrasodium EDTA at a specific mixing ratio. It was confirmed that the mortality rate of species bacteria, one fungus, one yeast, and Burkholderia was 100%.

number Potassium Benzoate Sodium anisate Ethylhexylglycerin levulinic acid Glyceryl Caprylate caprylyl glycol hexanediol pentanediol Decanediol Sodium Dehydroacetate Tetrasodium EDITA Purified water 7 types of bacteria 1 type of fungus, 1 type of yeast Burkholderia weight(%) mortality 2-1 0.2 0.25 0.15 to
100 100 100 100 2-2 0.2 0.25 0.1 to
100 100 100 100 2-3 0.2 0.2 0.15 to
100 100 100 100 2-4 0.2 0.2 0.1 to
100 99.9 99.9 100 2-5 0.2 0.05 0.05 to
100 99.9 99.9 99.9 2-6 0.2 0.025 0.1 to
100 99.9 99.9 99.9 2-7 0.2 0.15 0.01 to
100 99.9 99.9 99.9 2-8 0.2 0.5 0.05 to
100 99.9 99.9 99.9 2-9 0.2 0.1 0.1 to
100 99.9 99.9 99.9 2-10 0.2 0.1 0.08 to
100 99.9 99.9 99.9 2-11 0.2 0.08 0.12 to
100 99.9 99.9 99.9 2-12 0.2 0.12 0.12 to
100 99.9 99.9 99.9

<2-3> Analysis of tertiary antimicrobial substances and combinations

The antibacterial wet tissue composition of the present invention may further contain lauraminopropylene glycol, and the content of potassium benzoate is 0.2% of the total weight, and levulinic acid, tetrasodium EDTA and lauraminopropylene glycol The content of the compound of chol (Lauramino Propylene Glycol) was mixed as shown in Table 2 below, and the survival inhibition rate of 7 types of bacteria, 1 type of fungus, 1 type of yeast, and Burkholderia was confirmed by the method of Example 1.

As a result, as shown in Table 3 below, by mixing 0.2% of potassium benzoate, 0.15% to 0.2% of levulinic acid, 0.1% to 0.15% of tetrasodium EDTA, and 0.01% of laminopropylene glycol. It was confirmed that the mortality rate of bacteria and fungi 1 type, yeast 1 type, and Burkholderia was more than 99.9%, and 7 types of bacteria, 1 type of fungus, and 1 type of yeast were confirmed in the composition (3-1 to 3-3) containing a specific mixing ratio It was confirmed that the death rate of species and Burkholderia was 100%, and a synergistic effect in bacterial control could be obtained by adding 0.01% of laminopropylene glycol.

No. Potassium Benzoate levulinic acid Tetrasodium EDITA Lauraminopropylene glycol Purified water 7 types of bacteria 1 type of fungus, 1 type of yeast Burkholderia weight% mortality 3-1 0.2 0.2 0.15 0.01 to 100 100 100 100 3-2 0.2 0.2 0.1 0.01 to 100 100 100 100 3-3 0.2 0.15 0.15 0.01 to 100 100 100 100 3-4 0.2 0.15 0.1 0.01 to 100 100 99.9 100

As described above in detail a specific part of the present invention, for those of ordinary skill in the art, it is clear that this specific description is only a preferred embodiment, and the scope of the present invention is not limited thereby. something to do. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (7)

Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterobacter aureus containing 0.2 parts by weight of potassium benzoate, 0.2 to 0.25 parts by weight of levulinic acid, and 0.1 to 0.15 parts by weight of tetrasodium EDTA. Ginseng, Krebsiella pneumoniae, Salmonella, Micrococcus luteus, black mold, Candida albicans and a composition for wipes that kill Burkholderia. The method of claim 1,
When the composition further comprises 0.01 parts by weight of lauraminopropylene, the composition for wet tissues comprising 0.15 to 0.2 parts by weight of levulinic acid. A wet tissue comprising the composition of claim 1 .
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