KR20170130714A - A Cleanser composition containing hypochlorous acid and wet tissue comprising in the same - Google Patents

Abstract

The present invention relates to a cleanser composition containing hypochlorous acid and a wet tissue comprising the same, wherein the cleanser composition contains hypochlorous acid and plant-derived alcohol, thereby exhibiting excellent sterilizing power, being harmless to the human body, and having no skin irritation. Therefore, the cleanser composition can be substituted for cetylpyridinium chloride, which is a commonly used but is a toxic substance.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a cleanser composition using hypochlorous acid and a wet tissue containing the same,

The present invention relates to a detergent composition having excellent sterilizing power and being harmless to the human body and having no skin irritation, and a wet tissue including the detergent composition.

In recent years, income has increased, cleanliness has been emphasized, and as the interest in appearance has increased, the amount of wipes used is increasing. Specifically, the wipes are produced in various forms such as oral wipes, cleaning wet wipes, women's wet wipes, disposable wet wipes, and multipurpose wet wipes depending on the purpose of use. Since the wet wipes are simple and convenient to use, There is a trend.

These wipes are used directly to the skin of the human body, so they are excellent in safety to the skin, have excellent removability against foreign substances and pathogenic microorganisms remaining on the skin, and have a functional effect and efficacy that can improve the skin condition . In addition, since the wet tissue is used for a relatively long period of time after the package is opened, it is necessary to perform a preservative treatment using a preservative because the product tends to be deteriorated due to the characteristics of the product.

Particularly, in recent years, there has been an increasing tendency to place importance on health and wellness, and in order to satisfy such demands, various kinds of wet tissues are manufactured using natural materials.

Thus, conventionally, a certain amount of a synthetic preservative, which is a chemical compound synthesized, is added to the wet tissue to prevent the wet tissue from being deteriorated and corrupted. Although these preservatives are excellent chemical preservatives for wet tissues, they are chemical products made by synthesizing chemical substances. Therefore, it affects the skin of users of wet tissues, and it is naturally arranged with the demands and social trends of users of wet tissues that emphasize health and well- .

More specifically, chloromethylisothiazolinone (CTIM), cetylpyridinium chloride and PHMB (polyhexamethylene biguanide) are used as the presently produced infant and adult wet tissue, and 3-iodo-2-propynyl butyl And 3-lodo-2-propynylbutylcarbamate (IPBC). However, these substances are highly irritating to skin, and PHMG (polyhexamethylene guanidine), PHMB (polyhexamethylene biguanide) and PGH (oligo (2- (2-ethoxy) ethoxyethyl guanidine chloride) Is a guadine-based chemical substance.

In addition, cetylpyridinium chloride is a substance that is designated as a prohibited substance in the future because it is highly toxic to mice, causing respiratory diseases.

In addition, 3-iodo-2-propynylbutylcarbamate is a socially-challenged substance that is regulated by the Ministry of Health, Labor and Welfare as a harmful product for infant products, and development of a wet tissue using a substitute substance is required.

Korean Patent No. 1533195 Korea Patent No. 1476093

It is an object of the present invention to provide a detergent composition which is excellent in sterilizing power, is harmless to the human body and has no skin irritation.

Another object of the present invention is to provide a wet tissue including the detergent composition.

To attain the above object, the detergent composition for a wet tissue of the present invention may contain hypochlorous acid and plant-derived alcohol.

The plant-derived alcohol may be at least one selected from the group consisting of alpha terphenol, menthol, linarol and geraniol.

The detergent composition may comprise from 10 to 100 ppm hypochlorous acid and from 150 to 300 ppm plant-derived alcohol.

The hypochlorous acid and the plant-derived alcohol may be mixed in a weight ratio of 1: 3 to 20.

The detergent composition may further comprise at least one member selected from the group consisting of a moisturizing agent, a surfactant, and a flavoring agent.

According to another aspect of the present invention, there is provided a wet tissue of the present invention, wherein the cleaning composition is absorbed in an absorbent sheet.

The wet tissue may comprise from 1 to 99% by weight of a detergent composition.

The detergent composition of the present invention is excellent in sterilizing power and can reduce 95% or more of germs harmful to human body such as E. coli, is harmless to human body, and does not cause skin irritation because it does not cause rash or galling.

Also, since the detergent composition of the present invention satisfies the pH 5 to 6.5 similar to the pH of the skin, it is not necessary to perform a separate pH control process, and the manufacturing process is simple and economical.

The present invention relates to a detergent composition having excellent sterilizing power and being harmless to the human body and having no skin irritation, and a wet tissue including the detergent composition.

Conventionally, chemical agents such as cetylpyridizyl chloride, which is excellent in sterilizing power and sterilization persistence, are often used in a detergent composition for wet tissues. However, since most of the chemical substances are toxic, they are used as a substitute for a composition containing a toxic chemical substance The inventive cleaning composition was prepared.

Generally, a detergent composition for a wet tissue should be soluble in a solvent that does not give skin irritation, for example, water, 2) have a pH of 5 to 6.5 (weakly acidic) similar to the skin itself, and 3) Should be excellent, 4) it should not be toxic to human body, and 5) it should be excellent in sterilization persistence that does not decay at room temperature. "The detergent composition of the present invention satisfies all of the above five conditions do.

Hereinafter, the present invention will be described in detail.

The detergent compositions of the present invention include hypochlorous acid (HClO), plant derived alcohols and solvents.

The hypochlorous acid is a sterilizing agent which sterilizes water, food, tableware and the like for pharmaceutical use, releases unstable oxygen, decomposes, and produces hydrochloric acid and chloric acid. Since hypochlorous acid is unstable, it must be stored at -20 占 폚 for a few days to be stored, so that it is not suitable to be applied to a wet tissue which must be stored at room temperature by absorbing a cleaning agent composition on an absorbent sheet.

 Therefore, a plant-derived alcohol is used in order to have a high chemical stability against the hypochlorous acid. When the plant-derived alcohol is used, the hypochlorous acid of hypochlorous acid and the positive charge of the plant-derived alcohol electrically act to stabilize hypochlorous acid, and thus it is possible to store hypochlorous acid even at room temperature for several days. Further, when hypochlorous acid is used together with hypochlorous acid and plant-derived alcohol, the sterilizing activity and the sterilization continuing power are further enhanced.

The plant-derived alcohol may be at least one selected from the group consisting of alpha-terphenol, menthol, linarol, and geraniol, and the alcohols obtained by fractional extraction of plants are preferably alpha-terphenol .

The hypochlorous acid is used in an amount of 10 to 100 ppm, preferably 30 to 60 ppm. When the content of hypochlorous acid is less than the lower limit, the sterilizing activity and the sterilization sustaining power may be lowered. If the content is above the upper limit, toxicity may be induced and the manufacturing cost may increase.

The plant-derived alcohol is used in an amount of 150 to 300 ppm, preferably 200 to 250 ppm. If the content of the plant-derived alcohol is less than the above lower limit, storage at normal temperature is impossible and the bactericidal activity is lowered. If the content of the plant-derived alcohol is higher than the upper limit, sterilization persistence may be lowered.

The hypochlorous acid and the plant-derived alcohol are mixed at a weight ratio of 1: 3 to 20, preferably 1: 4 to 10. Hypochlorous acid may not be stabilized if the content of plant-derived alcohol is lower than the lower limit based on hypochlorous acid, and if the content is above the upper limit, sterilization persistence may be lowered and the manufacturing cost may be increased.

The solvent may be purified water, such as pure water, ultrapure water or purified water.

Conventional detergent compositions for wet tissues use citric acid, triethanolamine or the like which may cause skin irritation for pH control. However, the detergent composition for wet tissues of the present invention has a pH of 5 to 6.5 by using hypochlorous acid and a plant- Therefore, it is not necessary to use a pH adjusting agent separately.

The detergent composition for wet tissues of the present invention may further contain at least one selected from the group consisting of moisturizers, surfactants, and fragrances in an amount of 200 to 500 ppm, if necessary.

Examples of the moisturizing agent include at least one selected from the group consisting of propylene glycol, natural extract, glycerol and sorbitol; Examples of the surfactant include at least one selected from the group consisting of benzalkonium chloride, sodium phosphate, ethanol (emulsifier), and polyethylene glycol; As the fragrance, natural fragrance or synthetic fragrance may be used.

The present invention also provides a wet tissue including the detergent composition.

The wet tissue of the present invention can be prepared by soaking the absorbent sheet in the detergent composition or by spraying the detergent composition onto the absorbent sheet.

The absorbent sheet may be a nonwoven fabric or a pulp.

The nonwoven fabric is formed in the same shape as a nonwoven fabric made of cotton, cellulose, synthetic fiber or the like. Specifically, the nonwoven fabric may be a rayon series such as span lace, air laid, chemical bonding, meltblown, , And is preferably a span lace or an air laid having a good texture.

As the pulp, natural pulp or the like may be used.

The wipes may contain 1 to 99% by weight of the detergent composition in the absorbent sheet.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the present invention. Such variations and modifications are intended to be within the scope of the appended claims.

<Production Example>

Production Example 1. Preparation of hypochlorous acid

A hypochlorous acid aqueous solution having a hypochlorous acid content of 50 ppm was prepared by electrolytically decomposing a mixed water containing purified water and hydrochloric acid for food addition by a septum membrane having a mesh electrode.

&Lt; Examples and Comparative Examples &

Example 1. Hypochlorous acid + alpha terphenol

A detergent composition was prepared by adding 230 ppm of alpha terphenol (Sigma Aldrich) to the hypochlorous acid aqueous solution prepared in Preparation Example 1.

Example 2. Hypochlorous acid + menthol

A cleaning composition was prepared in the same manner as in Example 1 except that menthol was used instead of alpha terphenol.

Comparative Example 1. Hypochlorous acid alone

An aqueous hypochlorous acid solution prepared according to Preparation Example 1 was used.

Comparative Example  2. Alpha terphenol  Exclusive

Alpha terphenol was used.

Comparative Example 3 Hypochlorous acid + alpha terphenol

A hypochlorous acid aqueous solution was used in the same manner as in Example 1 except that the amount of alpha terphenol was changed to 100 ppm.

< Test Example >

Test Example  1. Measurement of cell proliferation effect using cell culture

In order to confirm cell proliferation and toxicity, the detergent compositions prepared according to Examples and Comparative Examples were tested.

1) Experimental method

The cytotoxicity and proliferation experiments were carried out in the following manner. The cultured cells (5roblast, 3T3) were seeded in a 96-well microplate at 5,000 cells / well, cultured in a thermostat for 30 minutes, and cultured for 72 hours. Thiazoline blue was added and the cells were further cultured for 4 hours. The culture medium was discarded, and the reaction suspension was added to each well of the microplate. After stirring for 5 minutes, the absorbance at 570 nm was measured. The control group was co-cultured with 10% Fetal Bovine Serum (FBS) medium as the optimal condition for cell growth, and the cell proliferation rate of the test sample was calculated with the cell proliferation of the control group as 100% .

2) Experimental results

The cell proliferation effect was calculated by the following equation (1), and the results are shown in Table 1 below.

[Equation 1]

division Control group Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Cell proliferation rate
(%) 0 98.4 94.8 30.1 80.8 88.6

As shown in Table 1, it was confirmed that the detergent compositions prepared according to Examples 1 and 2 of the present invention had better cell proliferation effects than Comparative Examples 1 to 3. This means that the detergent compositions prepared according to Examples 1 and 2 are harmless to the human body since they are not toxic.

Test Example 2: Antibacterial test with Escherichia coli

In order to confirm the antibacterial activity against Escherichia coli, the detergent compositions prepared according to Examples and Comparative Examples were tested.

1) Experimental method

Escherichia coli (ATCC 25922) was used for the antimicrobial test against Escherichia coli according to the KFIA-FI-1002 test method.

2) Experimental results

The bacteriostatic reduction rate against Escherichia coli after 24 hours is shown in Table 2 below.

division Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Bacteriostatic reduction rate
(%) 99.9 96.4 40.7 23.5 75.1

As shown in Table 2, the detergent compositions prepared according to Examples 1 and 2 of the present invention were found to be superior in fungicidal activity because the reduction rate of E. coli was very high as compared with Comparative Examples 1 to 3.

Test Example 3. Investigation of the degree of dermatitis

Spatters were dipped in a detergent composition prepared according to the examples and comparative examples for 30 seconds, respectively. The wipes were used for 20 months for 1 month, and the degree of rash and dermatitis were examined. The method of use is to observe the skin condition of the used area at 5 grade after each use for 1 month for removal of foreign matter. The fifth grade of skin condition is shown in Table 3 below.

0: No visible abnormality of the skin

1: Weak redness and skin changes at the site of use

2: The redness of the used site and weak barking

3: Swelling and galling of the used site

4: Significant redness and galling of the used area

division Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Skin rating 0 18 13 0 15 12 One 2 6 2 2 4 2 0 One One 3 4 3 0 0 4 0 0 4 0 0 13 0 0 More than 0 grade%
(clear) 90 65 0 75 60

As shown in Table 3, it was confirmed that the wet tissue produced with the detergent composition prepared according to Examples 1 and 2 of the present invention is superior in the effect of suppressing rash or barking as compared with Comparative Examples 1 and 3. Particularly, it was confirmed that Example 1 exhibited an excellent effect as compared with Example 2.

The alpha-terphenol of Comparative Example 2 was derived from plants and was widely used in aroma oils, and it was confirmed that no stimulation was given to the skin.

Test Example  4. Identification of hazardous substances

Hazardous substances were identified with the detergent composition prepared according to Example 1, and this was carried out by the Korean Institute of Industrial Technology.

division Hazardous Substances Example 1 Reference value Test Methods Heavy metal content (mg / kg) Lead (Pb) 3.0 20 or less KSK 0852 Mercury (Hg) 0.5 20 or less Arsenic (As) 0.5 20 or less Cadmium (Cd) 0.5 20 or less Chromium (Cr) 0.5 20 or less Fluorescent whitening agent (mg / kg) Non-detection Not to be detected KSM 2709 Formaldehyde (mg / kg) 10 20 or less ISO 17226-1

As shown in Table 4, it was confirmed that the detergent compositions prepared according to Example 1 of the present invention had both heavy metals, fluorescent whitening agents and formaldehyde measured below the standard values.

This means that the detergent composition prepared according to Example 1 is a harmless substance to the human body.

Claims (7)

Wherein the detergent composition comprises hypochlorous acid and plant-derived alcohol. The detergent composition according to claim 1, wherein the plant-derived alcohol is at least one selected from the group consisting of alpha terphenol, menthol, linarol, and geraniol. The detergent composition of claim 1, wherein the detergent composition comprises 10 to 100 ppm of hypochlorous acid and 150 to 300 ppm of a plant-derived alcohol. The detergent composition according to claim 1, wherein the hypochlorous acid and the plant-derived alcohol are mixed in a weight ratio of 1: 3 to 20. The detergent composition according to claim 1, wherein the detergent composition further comprises at least one member selected from the group consisting of a moisturizer, a surfactant, and a dye. A wet tissue comprising the detergent composition of any one of claims 1 to 5. 7. The wet tissue according to claim 6, which comprises 1 to 99% by weight of the detergent composition.