WO2020138773A1

WO2020138773A1 - Stable liquid composition for preserving cosmetics, containing pca ethyl cocoyl arginate

Info

Publication number: WO2020138773A1
Application number: PCT/KR2019/017490
Authority: WO
Inventors: 동은수; 손가영; 권세나
Original assignee: 주식회사 명진뉴텍
Priority date: 2018-12-28
Filing date: 2019-12-11
Publication date: 2020-07-02
Also published as: CN112566619A; KR102049844B1

Abstract

The present invention relates to a stable liquid composition for preserving cosmetics, containing PCA ethyl cocoyl arginate, and it was confirmed that PCA ethyl cocoyl arginate is homogeneously dissolved in a liquid prepared by adding one or more types selected from the group consisting of a C5-12 polyol and an organic acid to PCA ethyl cocoyl arginate, and the liquid has excellent sterilizing effect on bacteria and fungi while the liquid state is stably sustained, and thus the composition for preserving cosmetics, of the present invention, is expected to be capable of replacing the currently used cosmetic preservatives.

Description

Stable composition for preserving cosmetics in a stable liquid state containing P.C. ethyl cocoyl alginate

The present invention relates to a composition for preserving a cosmetic in a stable liquid state containing PCA ethyl cocoyl arginate, specifically C5 to 12 polyalcohols (polyol) of ethyl ethyl cocoyl alginate, and It relates to a composition for preserving cosmetics comprising at least one compound selected from the group consisting of organic acids.

Cosmetics are products that are used in a similar way, such as "cleaning and beautifying the human body, adding charm, changing the appearance brightly, or applying, rubbing, or spraying on the human body to maintain or promote health of the skin and hair. It is defined as "Minor" (Ministry of Food and Drug Safety, 2012), and thousands of substances are used as components of a complex of various chemicals. Among them, oil and water are the main components, and glycerine or sorbitol, which is a carbon source for microorganisms, and amino acid derivatives and proteins, which are nitrogen sources, are often mixed. There is a possibility (Judeok Kim, et al., 2004). Therefore, a preservative (preservative) is essential for long-term storage of cosmetics from deterioration and deodorization caused by microorganisms due to contamination by microorganisms while using cosmetics.

Preservatives are used in many consumer goods such as food, beverages, pharmaceuticals, and cosmetics to prevent physical and chemical changes such as decay and deterioration caused by the growth of microorganisms. Preservatives are usually used in combination of two or more to enhance their effect (Berke, P.A., et al., 1982; Jackson, E.M., 1995; Berke, P., et al., 1980). In Korea, the sterilizing and preserving agents that can be used in cosmetics are limited to about 50 types, such as parabens and phenoxyethanol, and these sterilizing and preserving ingredients have safety problems such as cytotoxicity and contact allergy. By inhalation, the type and amount of use are regulated by the standard of cosmetic ingredients (Ministry of Food and Drug Safety, 2009; Anselmi, C., et al., 2002).

Preservatives, which are used as the most common antiseptic preservatives, are known to be non-toxic as parabens and have been used for a long time since 1920. However, recently, studies on paraben estrogen have been reported, such as parabens through cosmetic use due to paraben's estrogenicity (Routledge, EJ, et al., 1998; Derbre, PD , et al., 2002) and research reports that parabens tend to cause carcinogenesis by continuous UV exposure (Anhae Sun, et al., 2009). .

Another preservative, phenoxyethanol, is widely used in skin-related products such as cosmetics and various bath products because it exhibits a wide range of preservative action against fungi, bacteria, and insects. However, in some cases, research results have been reported that generating free radicals can cause spots, freckles, and skin irritation and allergies (Byeong-Jo Ha, 2007). Evading.

Therefore, as an alternative to these preservatives, several raw materials are sold in the market under the name of preservative substitutes. A preservative substitute is a substance that has an antiseptic effect without being subject to a raw material item that requires restrictions on the use of cosmetic ingredients prescribed by the Ministry of Food and Drug Safety. A typical example is hexanediol. Hexanediol is currently used most in the preservative market, but it has a disadvantage that the antiseptic effect is remarkably lowered, so that an excessive amount must be added, and the usability and stability of the product are deteriorated due to excessive use. However, there is no substitute for it, and it is being used continuously. Another antiseptic alternative is ethylhexylglycerin, but ethylhexylglycerin can be obtained by using at least 0.1% of the preservative, but is known to cause skin irritation when 0.05% or more is used.

Burkholderia is an aerobic gram-negative bacterium present in soil, water, etc., which is resistant to several antibacterial agents and is strong enough to be found in disinfectants that kill bacteria. There are more than 40 varieties of Burkholderia, and control methods are different for each species, and it is difficult to manage because there are some species that form biofilms. In the United States, there is an example in which a recovery action has been taken due to the contamination of cosmetics by Burkholderia, and control of Burkholderia is considered important in disinfectants and preservatives.

PCA ethyl cocoyl arginate (CAE) is derived from L-arginine, DL-pyrrolidone carboxylate (DL-PCA) and fatty acid It is a cationic surfactant based on amino acids, and is safe from skin irritation because it is derived from amino acids. Currently, P.C. ethyl cocoyl alginate is used as a hair conditioning agent, and is known to have a preservative effect on bacteria, but its preservative effect on fungi is weak when used alone. In particular, in the case of cosmetics, it is difficult to use it as a preservative because it is highly likely to be contaminated by fungi such as fungi and yeast as well as bacteria.

On the other hand, since cosmetics contain water from as little as 5% to as much as 80% or more, depending on the solubility of the additive component in water, it may affect the usability and quality of the cosmetic. In addition, even if it dissolves, it can be an important factor for how long it maintains a stable shape under various temperature conditions. Cosmetics have a shelf life of up to three years, and the consumer's expiration date may be longer. Therefore, the importance of maintaining cosmetics in a stable state for a long time is a factor that is obviously accepted in the art. In particular, in Korea, the seasonal temperature difference is very large due to seasonal characteristics, so maintaining the stability of cosmetics is more important.

However, PQ ethyl cocoyl alginate is difficult to store after being diluted with a poorly soluble substance. In general, poorly soluble substances are made by adding emulsifiers such as polysorbate 80, polyethylene glycol (PEG) 40 stearate, and ceteth 10 to make diluents. In addition to being an unnecessary addition component, the P.C. ethyl cocoyl alginate has a solubility of less than 0.3% even when an emulsifier is used, and has the property of solidifying at low temperatures even when an emulsifier is added. In addition, even when the PCA ethyl cocoyl alginate solution is heated and is made into an aqueous solution, when cooled to below 15°C, it becomes an insoluble semi-solid form, and the insoluble semi-solid form AC ethyl cocoyl alginate is transparent again at room temperature. It does not turn into a liquid and can be melted only when heated to 45°C or higher, which increases the working time and decreases product productivity.

Therefore, it is somewhat difficult to add to the cosmetics while maintaining the stable state of P.C.ethyl cocoyl alginate, and P.C.ethyl cocoyl alginate is in the form of fine powder, which may adversely affect health when inhaled by workers. .

Accordingly, the present inventors, in the process of developing a cosmetic preservative containing a main component of P.C.ethyl cocoyl alginate, the P.C.ethyl cocoyl alginate solution made by mixing polyethyl alcohol or organic acids with P.C.ethyl cocoyl alginate continuously While maintaining a stable state, it was possible to complete the present invention by confirming that it is possible to compensate for the low antifungal effect due to the use of P.C. ethyl cocoyl alginate alone.

Korean Patent Publication No. 2003-0017358, which is a prior art, describes the antiseptic and bactericidal properties of N-cocoyl-L-arginine ethyl ester-DL-pyrrolidone carboxylate (PCA ethyl cocoyl alginate). Mixing with a polyhydric alcohol or an organic acid for preparing a solution in a stable state of the poorly soluble substance, P.C. ethyl cocoyl alginate, and the increased antibacterial effect thereof are not described. In addition, Korean Registered Patent No. 1779131 describes a preservative for external preparations for skin containing polyols of diols, but the mixed composition with polyalcohols for preparing a stable solution of PC ethyl ethyl cocoyl alginate Not stated and implied at all.

An object of the present invention is to provide a composition for preserving a cosmetic in a stable liquid state containing PCA ethyl cocoyl arginate.

The present invention a) PCA ethyl cocoyl alginate (PCA ethyl cocoyl arginate); b) at least one compound selected from the group consisting of C5-12 polyhydric alcohols and organic acids; It relates to a composition for preserving cosmetic comprising a.

The cosmetic composition for preservation is a) P.C. ethyl cocoyl alginate 0.001 ~ 10% by weight; And b) 0.01 to 40% by weight of at least one compound selected from the group consisting of polyhydric alcohols of C5 to 12 and organic acids.

The cosmetic composition for preservation is a) PC ethyl cocoyl alginate; And b) at least one compound selected from the group consisting of polyhydric alcohols of C5 to 12 and organic acids; these may be mixed at a weight ratio of 1:1 to 1000.

The polyhydric alcohols of C5 to 12 may preferably be one or more kinds selected from the group consisting of polyhydric alcohols of C6 to 10.

The organic acid is ferulic acid, anisic acid, sodium anisate, levulinic acid, sodium levulinate, benzoic acid, sodium benzoate (sodium benzoate), sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, propionic acid, sodium propionate, formic acid ( It may be one or more selected from the group consisting of formic acid and sodium formate.

The cosmetic preservation composition may maintain a liquid state by uniformly dissolving PCA ethyl cocoyl alginate at 20-25°C.

The cosmetic preservation composition is Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Aspergillus brasiliensis, Candida albicans, Burkholderia gladioli , Burkholderia lata and Burkholderia contaminans .

In addition, the present invention provides a cosmetic composition containing the cosmetic composition for preservation.

The cosmetics are made of lotion, skin softener, skin toner, astrigent, cream, foundation, essence, pack, soap, body cleanser, cleansing foam, shampoo, conditioner, hair treatment, hair mousse, hair colorase and makeup products It may consist of one or more formulations selected from the group.

Hereinafter, the present invention will be described in detail.

The present invention is a) PC ethyl cocoyl alginate; And b) at least one compound selected from the group consisting of polyhydric alcohols of C5 to 12 and organic acids; and to a composition for preserving cosmetic.

The cosmetic composition for preservation is based on the total weight of the composition a) PC ethyl ethyl cocoyl alginate 0.001 to 10% by weight; And b) 0.01 to 40% by weight of at least one compound selected from the group consisting of polyhydric alcohols of C5 to 12 and organic acids.

The cosmetic composition for preservation is a) PC ethyl cocoyl alginate; And b) at least one compound selected from the group consisting of polyhydric alcohols of C5 to 12 and organic acids; these may be mixed at a weight ratio of 1:1 to 1000. It is preferably mixed at a weight ratio of 1:1 to 100, and more preferably mixed at a weight ratio of 1:1 to 10. If a) at least one compound selected from the group consisting of polyhydric alcohols and organic acids of C5 to 12 is contained in an amount of less than one-fold based on a) ethyl ethyl cocoyl alginate, the PC ethyl ethyl cocoyl alginate is completely dissolved. It is not desirable. On the other hand, when a) more than 1000 times selected from the group consisting of polyhydric alcohols and organic acids of C5-12 based on a) ethyl cocoyl alginate, the antibacterial activity and stability are similar to 1000 times. Therefore, it is not preferable in terms of manufacturing cost.

In the present invention, "PCA ethyl cocoyl alginate (PCA ethyl cocoyl arginate)" L-arginine (L-arginine), DL-pyrrolidone carboxylate (DL-pyrrolidone carboxylate, DL-PCA) and fatty acids ( fatty acid-derived amino acid-based cationic surfactant, which is safe for skin irritation, has excellent antibacterial effects on bacteria, but has low antibacterial effects on fungi. In addition, PCA ethyl cocoyl alginate is a poorly soluble substance, and even when dissolved with an emulsifier, its solubility is less than 0.3%, and may be solidified when the temperature decreases during storage, and when cooled below 15°C, insoluble semi-solid form It is converted to a liquid state only when it is heated to 45°C or higher, which makes it somewhat difficult to add it to cosmetics.

In the present invention, "polyhydric alcohol (polyol)" is an aliphatic compound having two or more hydroxyl groups (-OH). If the hydroxyl group is two, it is called a dihydric alcohol, and if it is three, it is called a trihydric alcohol. The dihydric alcohol is called glycol or diol, and typical dihydric alcohols include ethylene glycol and propylene glycol. The trihydric alcohol is called glycerol, and representative examples thereof include glycerin, trimethylol propane, and hexane triol.

The polyhydric alcohols of C5 to 12 are pentanediol (C5), hexanediol (C6), heptanediol (C7), octanediol (C8), nonanediol (C9), decanediol It may be one or more selected from the group consisting of (decanediol, C10), undecanediol (C11), and dodecanediol (C12). Preferably, it is at least one selected from the group consisting of C6 to C10 polyhydric alcohols, such as hexanediol, heptanediol, octanediol, nonanediol and decandiol. However, it is not limited thereto.

The hexanediol may be 1,2-hexanediol or 1,6-hexanediol, but is not limited thereto.

The heptanediol may be 1,7-heptanediol, but is not limited thereto.

The octanediol may be 1,2-octanediol or 1,8-octanediol, but is not limited thereto.

The nonanediol may be 1,2-nonanediol, 1,5-nonanediol or 1,9-nonanediol, but is not limited thereto.

The decanediol may be 1,1-decanediol, 1,2-decanediol or 1,10-decanediol, but is not limited thereto.

In the present invention, "organic acid (organic acid)" refers to an acid that is an organic compound, a variety of varieties such as tartaric acid, citric acid, lactic acid, food additives such as acidulants, seasonings, stabilizers, strengthening agents, preservatives, cosmetic ingredients and It is used for medicinal purposes.

The organic acid is ferulic acid, anisic acid, sodium anisate, levulinic acid, sodium levulinate, benzoic acid, sodium benzoate (sodium benzoate), sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, propionic acid, sodium propionate, formic acid ( It may be one or more selected from the group consisting of formic acid and sodium formate. It is preferably one or more selected from the group consisting of levulinic acid, sodium levulinate, anise acid, sodium aniseate, benzoic acid and sodium benzoate. However, it is not limited thereto.

The a) PC ethyl cocoyl alginate; And b) at least one compound selected from the group consisting of polyhydric alcohols of C5 to 12 and organic acids; the composition for preserving a cosmetic comprising 15° C. or higher while maintaining a homogeneous liquid state continuously, at less than 15° C. It solidifies in a semi-solid state, but when left at 25°C or higher, becomes a homogeneous liquid state again, and may have increased stability.

The cosmetic preservation composition is Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Aspergillus brasiliensis, Candida albicans, Burkholderia gladioli , Burkholderia lata and Burkholderia contaminans. However, it is not limited thereto.

The composition for preserving cosmetics may be used as it is or diluted with a lotion.

Dilution of the composition for preserving the cosmetic may be diluted 1 to 1000 times based on the total weight of the diluent, but this may vary according to the judgment of those skilled in the art.

The cosmetic composition may contain 0.1 to 10% by weight based on the total weight of the cosmetic composition. It is preferably 0.1 to 5% by weight. However, it is not limited thereto.

The cosmetics are for lotions, skin softeners, skin toners, astrigents, creams, foundations, essences, packs, mask packs, soaps, body cleansers, cleansing foams, shampoos, conditioners, hair treatments, hair mousses, hair colorases and makeup It may be made of one or more formulations selected from the group consisting of products, but is not limited thereto.

The sheet used in the mask pack is a group consisting of cotton, rayon, polyester, viscose rayon, nylon, polypropylene, polyester, tencel, acrylic, vinylon, casein glass fiber, pulp, hydrogel and virocellulose One or more fibers selected from can be used.

The present invention relates to a composition for the preservation of a cosmetic in a stable liquid state containing PCA ethyl cocoyl arginate, consisting of C5 to 12 polyalcohols (polyol) and organic acids in PC ethyl ethyl cocoyl alginate It was confirmed that P.C. ethyl cocoyl alginate is homogeneously dissolved in a liquid prepared by adding one or more selected from the group, and that the liquid state has excellent sterilizing ability against bacteria and fungi while maintaining a stable state.

Through this, it is expected that the cosmetic preservation composition of the present invention can replace the cosmetic preservative currently used.

Figure 1 shows the results of confirming the stability in the liquid state of the cosmetic composition for preservation of the present invention.

Figure 2 shows the results confirming the antimicrobial activity of the cosmetic composition for preservation of the present invention.

Figure 3 shows the results confirming the stability of the cosmetic composition containing the cosmetic composition for preservation of the present invention.

Hereinafter, a preferred embodiment of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the contents introduced herein are thorough and complete, and are provided to sufficiently convey the spirit of the present invention to those skilled in the art.

The materials corresponding to the components and contents of Table 1 were put in purified water passed through an ion exchange resin and mixed to prepare a composition for preserving the cosmetic composition of the present invention.

A composition for preservation of a cosmetic composition for comparison was prepared by mixing substances corresponding to the components and contents of Table 2 below into purified water passed through an ion exchange resin and mixing them.

PS ethyl cocoyl alginate is a poorly soluble substance, and is difficult to store and use in a liquid state. Moreover, even if it is heated to form a liquid state, if the temperature during storage falls below 15°C, it becomes an insoluble semi-solid, and it must be heated to 45°C or more to make it a liquid state again. Thus, the stability in the liquid state of the composition for preserving the cosmetic of the present invention was confirmed.

The compositions for preserving the cosmetic compositions of Example 1 and Comparative Example 1 were prepared and stored at 2°C for 3 days, then transferred to 25°C for 3 days, and then the presence or absence of dissolution of P.C. ethyl cocoyl alginate was confirmed. The results are shown in Figure 1 and Table 3 below. At this time, whether or not the dissolution of P.C. ethyl cocoyl alginate was determined by the precipitation of P.C.ethyl cocoyl alginate.

As shown in Fig. 1 and Table 3, when the composition for preserving the cosmetic composition of Example 1 was stored at 2° C. and transferred to 25° C., PK ethyl cocoyl alginate did not precipitate, and maintained a uniform liquid state. On the other hand, in the case of the composition for cosmetic preservation of Comparative Examples 1-1, 1-4 to 1-8, and 1-10 to 1-13, it was confirmed that PC ethyl ethyl cocoyl alginate precipitated and precipitated.

Through this, it can be seen that the composition for preserving the cosmetic composition of the present invention maintains a stable liquid state because P.C.ethyl cocoyl alginate does not precipitate even when stored at a low temperature in a liquid state.

When PCA ethyl cocoyl alginate is used as a preservative, it has an antibacterial effect on bacteria, but has a low antibacterial effect on fungi, so it is not only used as a preservative for cosmetics that are highly likely to be contaminated by fungi such as fungi, yeast, etc., as well as bacteria. There are difficulties. Thus, the antibacterial activity of the composition for preservation of cosmetics of the present invention against bacteria and fungi was confirmed.

The antimicrobial activity was confirmed using the cosmetic preservation compositions of Example 1 and Comparative Example 1, wherein the bacteria used a mixture of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Burkholderia gladioli, Burkholderia lata, Burkholderia contaminans as a fungus, and black fungus ( Aspergillus brasiliensis) as a fungus. And Candida albicans mixed bacteria.

The antibacterial activity experiment was performed according to US Pharmacopoeia standards. Specifically, in order to confirm the reduction and killing rate of the bacteria, the experiment was conducted by a plate culture method, and 10 ^7-8 CFU/mL of the bacterial mixed bacteria in the cosmetic preservative composition of Example 1 and Comparative Example 1, 10 ^5-6 CFU/ After inoculating each of the ㎖ fungi mixed bacteria or 10 ^7-8 CFU/ml of Burkholderia mixed bacteria and applying them to the plate medium, the bacteria were cultivated at 30-35° C. for 24 hours, and the Burkholderia bacteria were 30-35° C. At 48 hours, the fungus was cultured at 27°C for 5 days. At this time, as a control group, a bacterial mixed bacterium, a fungal mixed bacterium, or a Burkholderia mixed bacterium not treated with a cosmetic preservative composition was used. After culturing each bacteria, after counting the number of colonies of bacteria produced on the plate medium, the mortality rate of the bacteria was calculated using the following Equation 1, and the results are shown in FIG. 2 and Table 4 below. Did.

[Equation 1]

The criterion for mortality of bacteria for use as a composition for preserving cosmetics is 99.9% or more, and in the case of less than 99.9%, it is not suitable for application to a composition for preserving cosmetics.

As shown in Figure 2, in the case of the composition for cosmetic preservation of Example 1-1, some bacteria form colonies in a plate medium coated with bacteria, bacteria, or fungi, but compared with a control group without preservative treatment Thus, more than 99.9% of the bacteria were killed, and Examples 1-4 and 1-24 confirmed that the bacteria did not grow at all.

As shown in Table 4 above, which shows the mortality rate of these bacteria as a numerical value, in the case of the composition for preserving the cosmetic composition of Example 1, all of the bacterial, bacterial, and fungal mortality rates of the bacteria were 99.9% or higher. In the case of the composition for preserving the cosmetic composition of Comparative Example 1, it was confirmed that the mortality rate for each or all of bacteria, Burkholderia or fungi was less than 99.9%.

Furthermore, when looking at the results of the stability confirmation of the composition for preserving the cosmetic of Experimental Example 1 and the antibacterial effect, among the compositions for preserving the cosmetic of Comparative Example 1, of Comparative Examples 1-4 to 1-8, 1-12, 1-13 In the case, although the mortality rate for all the bacteria was 99.9% or more, it was confirmed that during the storage, PCA ethyl cocoyl alginate precipitated and the stability was poor.

Through this, in the case of the composition for preserving the cosmetic composition of the present invention, the preservation activity was significantly increased by increasing the low antibacterial activity against bacteria and Burkholderia as well as fungi caused by the use of P. ethyl ethyl cocoyl alginate alone, and It was also found that stability increased.

To confirm the stability of the cosmetic product containing the composition for preserving the cosmetic composition of the present invention, an essence solution for a mask sheet was prepared according to Table 5 below. After the prepared essence solution was left in a refrigerator at 2° C. for 24 hours, the formation or precipitation of precipitates in the solution was observed, and the results are shown in FIG. 3.

As shown in Fig. 3, in the case of the essence for the mask sheet containing the compositions for preserving the cosmetics of Examples 1-4 and 1-24, no precipitates or precipitates were observed, whereas Comparative Examples 1-1 and 1-5 In the case of the essence for the mask sheet containing the composition for preserving the cosmetic, fine needle-like precipitates in the form of needles were observed as indicated by the arrows.

Through this, it was found that when a cosmetic product is prepared using the cosmetic composition for preservation of the present invention, sediment or precipitate is not generated, and stability of the cosmetic product is maintained.

Claims

a) 0.001-10% by weight of PCA ethyl cocoyl arginate; And

b) pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, decanediol, undecanediol, dodecanediol ), 0.01 to 40% by weight of at least one compound selected from the group consisting of sodium anisate and sodium levulinate;

Including, a) and b) is a 1:1 to 1000 weight ratio, characterized in that the PCA ethyl cocoyl alginate is uniformly dissolved at 20 to 25 ℃ to maintain the liquid state continuously, 15 Even if it solidifies in a semi-solid state at less than ℃ ℃, it becomes a homogeneous liquid state when left at more than 25 ℃, Burkholderia gladioli, Burkholderia lata and Burkholderia contaminans The composition for preserving cosmetics having a sterilizing power of 99.9% or more.
According to claim 1,

The cosmetic preservation composition is characterized by having a sterilizing power of 99.9% or more in Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Aspergillus brasiliensis and Candida albicans At 20~25℃, the AC ethyl cocoyl alginate is uniformly dissolved to maintain the liquid state continuously, and even if it solidifies in a semi-solid state at less than 15℃, it becomes a homogeneous liquid state if left at 25℃ or higher. A composition for preserving cosmetics having a sterilizing power of 99.9% or more in Gladioli, Burgholderia rata and Burgholderia contaminans.
A cosmetic containing the composition for preserving the cosmetic of claim 1.
According to claim 3,

The cosmetics consist of lotion, skin softener, skin toner, astrigent, cream, foundation, essence, pack, soap, body cleanser, cleansing foam, shampoo, conditioner, hair treatment, hair mousse, hair colorase and makeup products Cosmetics characterized by consisting of one or more formulations selected from the group.