CN112566619A - Stable liquid composition for preserving cosmetic products containing PCA cocoyl arginine ethyl ester salt - Google Patents
Stable liquid composition for preserving cosmetic products containing PCA cocoyl arginine ethyl ester salt Download PDFInfo
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- CN112566619A CN112566619A CN201980047380.5A CN201980047380A CN112566619A CN 112566619 A CN112566619 A CN 112566619A CN 201980047380 A CN201980047380 A CN 201980047380A CN 112566619 A CN112566619 A CN 112566619A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The present invention relates to a stable liquid composition for preserving cosmetics containing PCA cocoyl arginine ethyl ester salt, and confirms that the PCA cocoyl arginine ethyl ester salt is uniformly dissolved in a liquid prepared by adding one or more selected from C5-12 polyhydric alcohol and organic acid to the PCA cocoyl arginine ethyl ester salt, the composition has an excellent sterilization effect on bacteria and fungi while continuously maintaining a stable liquid state, and thus, the composition for preserving cosmetics of the present invention is expected to be able to replace currently used cosmetic preservatives.
Description
Technical Field
The present invention relates to a stable liquid composition for preserving cosmetics containing PCA cocoyl arginine ethyl ester salt, and more particularly to a composition for preserving cosmetics comprising PCA cocoyl arginine ethyl ester salt and one or more compounds selected from C5-12 polyhydric alcohol and organic acid.
Background
Cosmetics are defined as "products which are applied, scattered or sprayed on the human body or used in a similar way for the purpose of keeping the human body clean, beautifying the human body, enhancing charm, changing the appearance, or maintaining or improving the health of the skin or hair, and have little influence on the human body" (Ministry of Food and Drug Safety, 2012). As a complex of various chemical substances, thousands of substances are used as its components. Among them, in many cases, oil and water are main components, and are mixed with glycerol or sorbitol, etc. which become carbon sources of microorganisms, and amino acid derivatives, proteins, etc. which become nitrogen sources, resulting in rapid propagation of microorganisms, which may cause deterioration of products (KIM, Joodeok, et al, 2004). Therefore, preservatives are essential for long-term storage of cosmetics to prevent deterioration and odor of cosmetics due to microbial contamination during use.
Preservatives are used in many consumer products, such as food, beverages, pharmaceuticals, cosmetics, and the like, to prevent physical, chemical changes such as spoilage and deterioration caused by microbial growth. In order to enhance the effect of preservatives, two or more preservatives are usually used in combination (Berke, P.A., et al., 1982; Jackson, E.M., 1995; Berke, P.E., et al., 1980). Sterilizing agents and preservatives available for cosmetics are limited to about 50 kinds in korea, including parabens, phenoxyethanol, and the like. The type and amount of these sterilizing agents and preservatives are limited by the standards of cosmetic raw materials because these substances are ingredients involved in safety problems such as cytotoxicity and contact allergy, etc. (department of food and drug safety, 2009; Anselmi, c., et al, 2002).
The most common preservative used as a sterilizing preservative is paraben. Parabens are not considered toxic and have been used for a long time since 1920. However, recent studies on the estrogenic properties of parabens have reported that parabens are associated with breast cancer through their use in cosmetics due to their estrogenic properties (Routeridge, E.J., et al, 1998; Derbre, P.D., et al, 2002). In addition, there are studies reporting that parabens tend to cause cancer by continuous exposure to ultraviolet radiation and the like (AN, Heasun, et al, 2009). Therefore, the use of paraben preservatives in cosmetics poses safety problems.
Because another preservative, phenoxyethanol, exhibits a broad preservative effect against molds, bacteria, and insects, phenoxyethanol has been widely used in skin-related products, such as cosmetics and many bath products, among others. However, it HAs been reported that phenoxyethanol produces active oxygen to cause chloasma and freckles in some cases, and that phenoxyethanol may cause skin irritation and allergy (HA, Byoungjo, 2007). In addition, consumers avoid phenoxyethanol due to side effects such as numbness in the skin.
Therefore, there are some raw materials on the market under the name substitution of corrosion inhibitors as a substitute for these preservatives. The preservative substitute is a substance having a preservative effect, but is not limited to be used as a raw material for cosmetics as regulated by the department of food and drug safety. A representative example thereof is hexylene glycol. Hexylene glycol is currently the most widely used preservative in the market, but the preservative efficacy is very low, requiring the addition of excess hexylene glycol. Thus, hexanediol has the disadvantage of reducing the usability and stability of the product due to its excessive use. However, since there is no substance that can replace hexylene glycol, hexylene glycol has been used. Another preservative alternative is ethylhexylglycerin (ethylhexylglycerin). Preservative effect can only be obtained when ethylhexyl glycerol is used in an amount of at least 0.1%. However, it is known that when the amount of ethylhexyl glycerin is 0.05% or more, skin irritation is caused.
Burkholderia (Burkholderia) is an aerobic gram-negative bacterium present in soil, water and the like, is resistant to various antibacterial agents, is a very strong bacterium, and can be found even in a bactericidal disinfectant. There are 40 types of burkholderia, each using a different control method. Certain types can form biofilms. Therefore, it is difficult to control Burkholderia. In the united states, there is a case where cosmetic contamination by burkholderia is caused and products are recalled. Therefore, control of burkholderia is considered important for disinfectants, antiseptics, and the like.
PCA cocoyl arginine ethyl ester (CAE) is an amino acid based cationic surfactant derived from L-arginine, DL-pyrrolidone carboxylate (DL-PCA) and fatty acids, which is safe in terms of skin irritation due to its derivation from amino acids. Currently, PCA cocoyl arginine ethyl ester salt is used as a hair conditioner. It is known that the ethyl cocoyl arginine PCA salt has a preservative effect on bacteria, but has little preservative effect on fungi when used alone. In particular, in the case of cosmetics, there is a high possibility that the cosmetic is contaminated not only with bacteria but also with fungi such as mold and yeast. Thus, it is difficult to use PCA cocoyl arginine ethyl ester salt as a preservative.
Meanwhile, the amount of water contained in the cosmetic is from as low as 5% to as high as 80% or more. Therefore, the water solubility of the added ingredients may affect the use feeling, quality, and the like of the cosmetic. In addition, the time for which the additive components can remain in a stable state under various temperature conditions may be an important factor even if they are dissolved. The shelf life of the cosmetic is 3 years, and the user's life may be longer. Therefore, it is obviously understood in the related art that it is important to maintain a stable state of cosmetics for a long time. Particularly in korea, the temperature difference between seasons is large due to seasonal characteristics, so it is more important to consider maintaining the stability of cosmetics.
However, the PCA cocoyl arginine ethyl ester salt is a poorly soluble substance and is therefore difficult to dilute and store. In general, for poorly soluble substances, a diluent is prepared by adding an emulsifier such as polysorbate 80, polyethylene glycol (PEG)40 stearate, cetyl ester 10(ceteth 10), or the like. However, such emulsifiers are not an essential additional ingredient. Furthermore, even with the emulsifier, the solubility of PCA cocoyl arginine ethyl ester salt was less than 0.3%, and it had the property of solidifying at low temperature even with the addition of the emulsifier. Furthermore, even if an aqueous solution is formed upon heating in the manufacture of the PCA cocoyl arginine ethyl ester salt solution, the PCA cocoyl arginine ethyl ester salt becomes an insoluble semi-solid form when cooled to 15 ℃ or less. The insoluble semi-solid form of the PCA cocoyl arginine ethyl ester salt does not revert to a clear liquid at room temperature and melts only after heating to temperatures above 45 ℃, which extends working time and reduces product productivity.
Thus, it is difficult to add the PCA cocoyl arginine ethyl ester salt to cosmetics while maintaining the stable state of the PCA cocoyl arginine ethyl ester salt. In addition, the PCA cocoyl arginine ethyl ester salt is in the form of a fine powder, and thus, if a worker inhales the powder, it may have an adverse effect on the health of the worker.
Accordingly, the present inventors completed the present invention by confirming that a PCA cocoyl arginine ethyl ester salt solution prepared by mixing PCA cocoyl arginine ethyl ester salt with a polyhydric alcohol or an organic acid can compensate for the low antifungal effect caused by the single use of PCA cocoyl arginine ethyl ester salt while continuously maintaining a stable state in the process of developing a cosmetic preservative containing PCA cocoyl arginine ethyl ester salt as a main ingredient.
Korean laid-open patent No. 2003-0017358 discloses the preservative and sterilization properties of N-cocoyl-L-arginine ethyl ester-DL-pyrrolidone carboxylate (PCA-cocoyl arginine ethyl ester salt). However, the prior art references do not disclose the combination of the PCA cocoyl arginine ethyl ester salt of the present invention with a polyol or organic acid to prepare a stable solution of the poorly soluble substance PCA cocoyl arginine ethyl ester salt, thus improving the antibacterial effect. Further, korean patent No. 1779131 discloses a preservative for skin external preparations, which contains polyhydric alcohols of glycol type. However, the prior art references do not disclose or suggest the inventive combination of PCA cocoyl arginine ethyl ester salt with a polyol to prepare a stable solution of PCA cocoyl arginine ethyl ester salt.
Disclosure of Invention
Technical purpose
It is an object of the present invention to provide a stable liquid composition for preserving cosmetics comprising PCA cocoyl arginine ethyl ester (PCA ethyl cocoyl argentate).
Means for solving the problems
The present invention relates to a composition for preserving cosmetics, comprising: a) PCA cocoyl arginine ethyl ester salt; b) a compound selected from one or more of a C5-12 polyol and an organic acid.
The composition for preserving cosmetics may comprise: a) 0.001-10% by weight of PCA cocoyl arginine ethyl ester salt; b)0.01-40 wt% of one or more compounds selected from C5-12 polyhydric alcohol and organic acid.
In a composition for preserving cosmetics, a) a PCA cocoyl arginine ethyl ester salt; and b) one or more compounds selected from the group consisting of C5-12 polyhydric alcohols and organic acids may be mixed in a weight ratio of 1:1 to 1000.
The C5-12 polyol may preferably be one or more selected from C6-10 polyols.
The organic acid may be one or more selected from ferulic acid, anisic acid, sodium anisate, levulinic acid, sodium levulinate, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, propionic acid, sodium propionate, formic acid, and sodium formate.
In a composition for preserving cosmetics, the PCA cocoyl arginine ethyl ester salt can be uniformly dissolved at 20-25 deg.C, and thus can be kept in a liquid state.
The composition for preserving cosmetics may have a sterilizing effect on Staphylococcus aureus (Staphylococcus aureus), Escherichia coli (Escherichia coli), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Aspergillus brasiliensis (Aspergillus brasiliensis), Candida albicans (Candida albicans), Burkholderia gladioli, Burkholderia lata (Burkholderia gladioli) and Burkholderia cepacia (Burkholderia Contaminans).
Further, the present invention provides a cosmetic comprising the composition for preserving a cosmetic.
The cosmetic may be formed into one or more formulations selected from the group consisting of lotions, skin softeners, skin fresheners, astringents, creams, foundations, essences, masks, soaps, bath gels, cleansing foams, shampoos, hair conditioners, hair treatment ointments, hair mousses, hair dyes, and cosmetic products.
Hereinafter, the present invention will be described in detail.
The present invention relates to a composition for preserving cosmetics, comprising: a) PCA cocoyl arginine ethyl ester salt; b) a compound selected from one or more of a C5-12 polyol and an organic acid.
The composition for preserving cosmetics may comprise, relative to the total weight of the composition: a) 0.001-10% by weight of PCA cocoyl arginine ethyl ester salt; b)0.01-40 wt% of one or more compounds selected from C5-12 polyhydric alcohol and organic acid.
In a composition for preserving cosmetics, a) a PCA cocoyl arginine ethyl ester salt; and b) one or more compounds selected from the group consisting of C5-12 polyhydric alcohols and organic acids may be mixed in a weight ratio of 1:1 to 1000, preferably 1:1 to 100, more preferably 1:1 to 10. When b) a compound selected from one or more of C5-12 polyol and organic acid is included in an amount of less than 1 times a) the PCA cocoyl arginine ethyl ester salt, the PCA cocoyl arginine ethyl ester salt is not completely dissolved and is therefore not preferred. When b) a compound selected from one or more of C5-12 polyol and organic acid is contained in an amount of more than 1000 times that of a) PCA cocoyl arginine ethyl ester salt, its antibacterial activity and stability are similar to those when used in an amount of 1000 times, which is not preferable in terms of manufacturing cost.
In the present invention, the "PCA cocoyl arginine ethyl ester salt" is an amino acid-based cationic surfactant derived from L-arginine (L-arginine), DL-pyrrolidone carboxylate (DL-PCA), and fatty acid, is safe in terms of skin irritation, and has an excellent antibacterial effect on bacteria, but has a low antibacterial effect on fungi. Also, cocoyl arginine ethyl PCA is a poorly soluble substance, which, even when dissolved with an emulsifier, has a solubility of less than 0.3%, may solidify if the temperature drops during storage, and becomes insoluble in a semi-solid form when cooled to below 15℃, and thus should be heated to above 45℃ to become liquid. Thus, it is somewhat difficult to add PCA cocoyl arginine ethyl ester salt to cosmetics.
In the present invention, "polyol" means an aliphatic compound having two or more hydroxyl groups (-OH), for example, a divalent alcohol having two hydroxyl groups and a trivalent alcohol having three hydroxyl groups. Divalent alcohols are called diols or diols. Representative examples of divalent alcohols are ethylene glycol, propylene glycol, and the like. Trivalent alcohols are known as glycerol. Representative examples of trivalent alcohols are glycerin (glycerol), trimethylolpropane (trimethylolpropane), hexanetriol (hexane triol), and the like.
The C5-12 polyol may be one or more selected from pentanediol (C5), hexanediol (C6), heptanediol (C7), octanediol (C8), nonanediol (C9), decanediol (C10), undecanediol (C11), and dodecanediol (C12). Preferably, the C5-12 polyol is one or more selected from C6-C10 polyols, such as one or more selected from the group consisting of hexanediol, heptanediol, octanediol, nonanediol, and decanediol, but is not limited thereto.
The hexanediol may be 1, 2-hexanediol or 1, 6-hexanediol, but is not limited thereto.
The heptanediol may be 1, 7-heptanediol, but is not limited thereto.
The octanediol may be 1, 2-octanediol or 1, 8-octanediol, but is not limited thereto.
The nonanediol may be 1, 2-nonanediol, 1, 5-nonanediol or 1, 9-nonanediol, but is not limited thereto.
The decanediol may be 1, 1-decanediol, 1, 2-decanediol or 1, 10-decanediol, but is not limited thereto.
In the present invention, "organic acid" means an acid as an organic compound, which has various types, such as tartaric acid, citric acid, lactic acid, and the like, and is used as a food additive, such as an acidulant, a seasoning, a stabilizer, a reinforcing agent, a preservative, and the like, and a cosmetic ingredient, and is used in pharmaceutical drugs.
The organic acid may be one or more selected from ferulic acid, anisic acid, sodium anisate, levulinic acid, sodium levulinate, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, propionic acid, sodium propionate, formic acid, and sodium formate. Preferably, the organic acid is one or more selected from the group consisting of levulinic acid, sodium levulinate, anisic acid, sodium anisate, benzoic acid, and sodium benzoate, but is not limited thereto.
A composition for preserving cosmetics comprising: a) PCA cocoyl arginine ethyl ester salt; b) a compound selected from one or more of C5-12 polyol and organic acid, which continuously maintains a uniform liquid state at a temperature above 15 ℃ and solidifies in a semi-solid state at less than 15 ℃, but returns to a uniform liquid state when left at above 25 ℃, which may increase stability.
The composition for preserving cosmetics may have a sterilizing effect against staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, aspergillus brasiliensis, candida albicans, burkholderia gladioli, burkholderia lata and burkholderia cepacia, but is not limited thereto.
The composition for preserving cosmetics may be used as it is or by dilution in cosmetic water.
The composition for preserving cosmetics may be diluted 1-1000 times based on the total weight of the diluent, but the dilution may be varied according to the judgment of those skilled in the art.
Further, the present invention provides a cosmetic comprising the composition for preserving a cosmetic.
The cosmetic may contain the composition for preserving the cosmetic in an amount of 0.1 to 10% by weight, preferably 0.1 to 5% by weight, relative to the total weight of the cosmetic, but is not limited thereto.
The cosmetics may be formed into one or more formulations selected from the group consisting of lotions, skin softeners, skin fresheners, astringents, creams, foundations, essences, masks, mask packs, soaps, body washes, cleansing foams, shampoos, conditioners, hair treatment ointments, hair mousses, hair dyes, and cosmetic products, but are not limited thereto.
The sheet used in the mask sheet may use fibers selected from one or more of cotton, rayon, polyester (polyester), viscose rayon, nylon, polypropylene, polyester, tencel, acrylon, vinylon, casein (casein), glass fiber, pulp, hydrogel, and bio-cellulose.
Effects of the invention
The present invention relates to a stable liquid composition for preserving cosmetics comprising PCA cocoyl arginine ethyl ester salt, and confirming uniform dissolution of the PCA cocoyl arginine ethyl ester salt in a liquid prepared by adding one or more selected from C5-12 polyhydric alcohol and organic acid to the PCA cocoyl arginine ethyl ester salt, the composition having excellent sterilizing effect against bacteria and fungi while continuously maintaining the liquid in a stable state.
Therefore, it is expected that the composition for preserving cosmetics of the present invention can replace currently used cosmetic preservatives.
Drawings
Fig. 1 shows the results of confirming the stability of the composition for preserving cosmetics of the present invention in a liquid state.
Fig. 2 shows the results of confirming the antibacterial activity of the composition for preserving cosmetics of the present invention.
Fig. 3 shows the results of confirming the stability of the cosmetic comprising the composition for preserving cosmetics of the present invention.
Detailed Description
Hereinafter, preferred embodiments of the present invention are described in detail. However, the present invention is not limited to the examples described below, but may be implemented in different embodiments. The embodiments are provided to complete and implement the invention herein and to fully convey the spirit of the invention to those skilled in the art.
Example 1 preparation of a composition for preserving cosmetics
The compositions for preserving cosmetics according to the present invention were prepared by putting materials corresponding to the ingredients and contents of table 1 below in purified water passed through an ion exchange resin and mixing.
[ Table 1]
Comparative example 1 preparation of composition for preserving cosmetics for comparison
The substances corresponding to the ingredients and contents of table 2 below were put into purified water passed through an ion exchange resin and mixed, thereby preparing a composition for preserving cosmetics for comparison.
[ Table 2]
Experimental example 1 confirmation of stability of composition for preserving cosmetic in liquid state
PCA cocoyl arginine ethyl ester is a poorly soluble substance and therefore it is difficult to store and use PCA cocoyl arginine ethyl ester in liquid form. Furthermore, even when heated to a liquid state, the PCA cocoyl arginine ethyl ester salt became an insoluble semi-solid when the temperature dropped below 15 ℃ during storage and only returned to a liquid state after heating to above 45 ℃. Accordingly, the stability of the composition for preserving cosmetics of the present invention in a liquid state was confirmed.
The compositions for preserving cosmetics of example 1 and comparative example 1 were prepared, preserved at 2 ℃ for 3 days, then moved to 25 ℃ and preserved for 3 days, and then it was confirmed whether or not the PCA cocoyl arginine ethyl ester salt was dissolved. The results are shown in fig. 1 and table 3 below. Here, it was judged whether or not the PCA cocoyl arginine ethyl ester salt was dissolved based on whether or not the PCA cocoyl arginine ethyl ester salt was precipitated.
[ Table 3]
As can be seen from fig. 1 and table 3 above, it was confirmed that when the composition for preserving cosmetics of example 1 was preserved at 2 ℃ and then moved to 25 ℃ for preservation, no PCA cocoyl arginine ethyl ester salt was precipitated, and the composition was maintained in a uniform liquid state. In contrast, it was confirmed that in the case of the compositions for preserving cosmetics of comparative example 1-1, comparative example 1-4 to comparative example 1-8, and comparative example 1-10 to comparative example 1-13, the PCA cocoyl arginine ethyl ester salt precipitated and precipitated.
Therefore, it can be understood that the composition for preserving cosmetics according to the present invention does not precipitate PCA cocoyl arginine ethyl ester salt even if the composition is stored in a liquid state at a low temperature, and thus maintains a stable liquid state.
Experimental example 2 confirmation of antibacterial Activity of composition for preserving cosmetic
When the PCA cocoyl arginine ethyl ester salt is used as a preservative, it is difficult to use the PCA cocoyl arginine ethyl ester salt as a preservative for cosmetics which are easily contaminated not only with bacteria but also with fungi such as mold, yeast and the like, since it has an antibacterial effect against bacteria but also has a low antibacterial effect against fungi. Therefore, the antibacterial activity against bacteria, fungi and the like of the composition for preserving cosmetics of the present invention was confirmed.
Antibacterial activity was confirmed using the compositions for preserving cosmetics of example 1 and comparative example 1. Here, for the bacteria, a mixture of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, for Burkholderia gladioli, Burkholderia latanova and Burkholderia cepacia, and for the fungi, a mixture of Aspergillus brazii and Candida albicans were used.
The antimicrobial activity test was performed according to the usp standards. Specifically, the test was performed using a plate culture method to confirm the reduction of bacteria and the mortality thereof. Will 107-8Bacteria mixture of CFU/ml, 105-6CFU/ml fungal cocktail or 107 -8A mixture of CFU/ml Burkholderia was inoculated into each of the compositions for preserving cosmetics of example 1 and comparative example 1, and spread on a plating medium. Thereafter, the bacteria were cultured at 30-35 ℃ for 24 hours; culturing Burkholderia at 30-35 deg.C for 48 hr; and the fungus was cultured at 27 ℃ for 5 days. Here, as a control group, a mixed bacterium of bacteria, a mixed bacterium of fungi, or a mixed bacterium of burkholderia, which was not treated with the composition for preserving cosmetics, was used. Each of the bacteria was cultured, the number of colonies of the bacteria grown on the plate medium was counted, and the mortality of the bacteria was calculated using the following formula 1. The results are shown in fig. 2 and table 4 below.
[ formula 1]
The mortality of the bacteria was ((number of inoculated bacteria in control group-number of viable bacteria present in sample-treated group)/number of inoculated bacteria in control group) × 100
The standard of the mortality of bacteria of the composition for preserving cosmetics to be used is 99.9% or more. At less than 99.9%, it is not suitable for use as a composition for preserving cosmetics.
[ Table 4]
As can be seen from fig. 2, in the case of the composition for preserving cosmetics of example 1-1, although some bacteria formed colonies in the plate medium coated with bacteria, burkholderia or fungi, more than 99.9% of the bacteria died, and no bacteria grew in examples 1-4 and 1-24, compared to the control group which was not treated with the preservative.
As can be seen from table 4 above, which shows the bacterial mortality as a numerical value, it was confirmed that the bacterial mortality of all the compositions for the bacteria, burkholderia or fungi reached 99.9% or more in the case of the composition for preserving cosmetics of example 1, while the bacterial mortality of the composition for each or all the bacteria, burkholderia or fungi was less than 99.9% in the case of the composition for preserving cosmetics of comparative example 1.
Further, from the results of confirmation of the stability of the composition for preserving cosmetics of the above experimental example 1 and the above antibacterial effect, it was confirmed that in the case of comparative examples 1-4 to 1-8, 1-12 and 1-13 among the composition for preserving cosmetics of comparative example 1, the composition had a mortality of 99.9% or more for all bacteria, but PCA cocoyl arginine ethyl ester salt precipitated during storage, and thus the stability of the composition was lowered.
Therefore, it is understood that in the case of the composition for preserving cosmetics of the present invention, by increasing the low antibacterial activity against fungi and the low antibacterial activity against bacteria and burkholderia caused by the use of the PCA cocoyl arginine ethyl ester salt alone, the preservative activity can be significantly improved, and the stability in storage is also improved.
Experimental example 3. confirmation of cosmetic containing composition for preserving cosmetic and stability thereof
In order to confirm the stability of the cosmetic containing the composition for preserving cosmetics of the present invention, the essence solution for a mask sheet was prepared according to the following table 5. The prepared essence solution was left in a refrigerator at 2 ℃ for 24 hours, and then generation or precipitation of precipitates and the like in the solution were observed. The results are shown in FIG. 3.
[ Table 5]
As can be seen from fig. 3, in the case of the essence for a facial mask sheet comprising the compositions for preserving cosmetics of examples 1 to 4 and examples 1 to 24, no precipitate or precipitate was observed. In contrast, in the case of the essence for a facial mask sheet comprising the compositions for preserving cosmetics of comparative examples 1-1 and comparative examples 1-5, fine needle-like precipitates were observed as indicated by arrows.
Therefore, it is understood that, in the case of manufacturing a cosmetic using the composition for preserving a cosmetic of the present invention, no precipitate, or the like is generated and the stability of the cosmetic is maintained.
Claims (4)
1. A composition for preserving cosmetics comprising:
a) 0.001-10% by weight of PCA cocoyl arginine ethyl ester salt; and
b)0.01 to 40% by weight of one or more compounds selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol, sodium anisate, and sodium levulinate,
characterized in that a) and b) are mixed in a ratio of 1:1 to 1000 by weight percent of the mixture,
wherein the PCA cocoylarginine ethyl ester salt is uniformly dissolved at 20-25 deg.C to continuously maintain a liquid state, solidifies in a semi-solid state at less than 15 deg.C, becomes a uniform liquid state when left at 25 deg.C or more, and has a sterilizing effect of 99.9% or more against Burkholderia gladioli (Burkholderia gladioli), Burkholderia lata (Burkholderia lata) and Burkholderia cepacia (Burkholderia Contamines).
2. The composition for preserving cosmetics according to claim 1, characterized by having sterilization effects of 99.9% or more against Staphylococcus aureus (Staphylococcus aureus), Escherichia coli (Escherichia coli), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Aspergillus brasiliensis (Aspergillus brasiliensis) and Candida albicans (Candida albicans), wherein PCA cocoyl arginine ethyl ester salt is uniformly dissolved at 20-25 ℃ to continuously maintain a liquid state, the composition becomes a uniform liquid state when left to stand at 25 ℃ or more even at below 15 ℃ in a semi-solid state, and the composition has sterilization effects of 99.9% or more against gladiobolus gladiolus, holbath lata and burkholderia cepacia.
3. A cosmetic comprising the composition for preserving cosmetics of claim 1.
4. The cosmetic according to claim 3, wherein the cosmetic is formed into one or more formulations selected from the group consisting of lotions, skin softeners, skin fresheners, astringents, creams, foundations, essences, masks, soaps, shower gels, cleansing foams, shampoos, conditioners, hair treatment ointments, hair mousses, hair dyes, and cosmetic products.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2018-0171910 | 2018-12-28 | ||
| KR1020180171910A KR102049844B1 (en) | 2018-12-28 | 2018-12-28 | Stable liquid composition for preserve of cosmetic comprising PCA ethyl cocoyl arginate |
| PCT/KR2019/017490 WO2020138773A1 (en) | 2018-12-28 | 2019-12-11 | Stable liquid composition for preserving cosmetics, containing pca ethyl cocoyl arginate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112566619A true CN112566619A (en) | 2021-03-26 |
Family
ID=68730293
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980047380.5A Withdrawn CN112566619A (en) | 2018-12-28 | 2019-12-11 | Stable liquid composition for preserving cosmetic products containing PCA cocoyl arginine ethyl ester salt |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR102049844B1 (en) |
| CN (1) | CN112566619A (en) |
| WO (1) | WO2020138773A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102049844B1 (en) * | 2018-12-28 | 2019-11-28 | 주식회사 명진뉴텍 | Stable liquid composition for preserve of cosmetic comprising PCA ethyl cocoyl arginate |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030162838A1 (en) * | 2001-08-21 | 2003-08-28 | Ajinomoto Co., Inc. | Bactericide, antiseptic, dermally applicable composition, washing composition, antibacterial fiber aggregate, method for eradicating a microorganism, and method for inhibiting the proliferation of a microorgamism |
| JP2004196712A (en) * | 2002-12-19 | 2004-07-15 | Noevir Co Ltd | Oil-in-water type emulsified composition |
| JP2005068095A (en) * | 2003-08-26 | 2005-03-17 | Mandom Corp | Antiseptic fungicide and cosmetic, medicine and food compounded with antiseptic fungicide |
| WO2010113683A1 (en) * | 2009-03-31 | 2010-10-07 | ライオン株式会社 | Sheet-like cosmetic |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170009702A (en) * | 2016-03-02 | 2017-01-25 | 주식회사 명진뉴텍 | Wet wipes composition and wet wipes containing the same including the troplone |
| KR102049844B1 (en) * | 2018-12-28 | 2019-11-28 | 주식회사 명진뉴텍 | Stable liquid composition for preserve of cosmetic comprising PCA ethyl cocoyl arginate |
-
2018
- 2018-12-28 KR KR1020180171910A patent/KR102049844B1/en active IP Right Grant
-
2019
- 2019-12-11 WO PCT/KR2019/017490 patent/WO2020138773A1/en active Application Filing
- 2019-12-11 CN CN201980047380.5A patent/CN112566619A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030162838A1 (en) * | 2001-08-21 | 2003-08-28 | Ajinomoto Co., Inc. | Bactericide, antiseptic, dermally applicable composition, washing composition, antibacterial fiber aggregate, method for eradicating a microorganism, and method for inhibiting the proliferation of a microorgamism |
| JP2004196712A (en) * | 2002-12-19 | 2004-07-15 | Noevir Co Ltd | Oil-in-water type emulsified composition |
| JP2005068095A (en) * | 2003-08-26 | 2005-03-17 | Mandom Corp | Antiseptic fungicide and cosmetic, medicine and food compounded with antiseptic fungicide |
| WO2010113683A1 (en) * | 2009-03-31 | 2010-10-07 | ライオン株式会社 | Sheet-like cosmetic |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102049844B1 (en) | 2019-11-28 |
| WO2020138773A1 (en) | 2020-07-02 |
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