JPH07330505A - Antimicrobial composition - Google Patents
Antimicrobial compositionInfo
- Publication number
- JPH07330505A JPH07330505A JP12635894A JP12635894A JPH07330505A JP H07330505 A JPH07330505 A JP H07330505A JP 12635894 A JP12635894 A JP 12635894A JP 12635894 A JP12635894 A JP 12635894A JP H07330505 A JPH07330505 A JP H07330505A
- Authority
- JP
- Japan
- Prior art keywords
- antibacterial
- antimicrobial
- substance
- composition
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【0001】[0001]
【産業上の利用分野】この発明は抗菌性組成物に関し、
特には化粧品、医薬品、食品等に好適に用いることがで
きる抗菌性組成物に関する。This invention relates to an antibacterial composition,
In particular, it relates to an antibacterial composition that can be suitably used for cosmetics, pharmaceuticals, foods and the like.
【0002】[0002]
【従来の技術】現在、様々な分野において、微生物が原
因となって発生する製品の汚染もしくは変質を防止し、
製品の保存性を確保するために、種々の殺菌剤や防腐剤
が保存剤(もしくは保存料)として用いられている。こ
のうち、生体に直接適用し、もしくは生体が摂取する製
品分野、特に香粧品、医薬品、食品等の分野において
は、生体の安全性を確保するために、使用可能な保存剤
の種類や適用量が定められていることが多い。例えば、
香粧品の分野では、厚生省告示によって保存剤は安息香
酸( 0.2%)、安息香酸塩類( 1.0%)、サリチル酸
( 0.2%)、サリチル酸塩類( 1.0%)、石炭酸( 0.1
%)、ソルビン酸およびその塩類( 0.5%)、デヒドロ
酢酸およびその塩類( 0.5%)、パラオキシ安息香酸エ
ステル( 1.0%)、パラクロルメタクレゾール( 0.5
%)、ビチオノール( 0.1%)、ヘキサクロロフェン
( 0.1%)、ホウ酸( 0.5%)およびレゾルシン( 0.1
%)に定められており(括弧内は最高使用濃度)、これ
らは表示義務成分でもある。また、医薬品の分野では、
安息香酸、安息香酸ナトリウム、塩化ベンザルコニウ
ム、塩化ベンゼトニウム、クレゾール、クロロブタノー
ル、チモール、パラオキシ安息香酸メチル、パラオキシ
安息香酸エチル、パラオキシ安息香酸プロピル、パラオ
キシ安息香酸ブチル、フェノールおよびベンジルアルコ
ールが保存剤として日本薬局方に収載されている。さら
に、食品分野では毒性を有する物質は用いることができ
ず、保存料として用いられるのは安息香酸およびそのナ
トリウム塩、ソルビン酸およびそのカリウム塩、デヒド
ロ酢酸およびそのナトリウム塩、パラオキシ安息香酸お
よびそのエステル(エチル、プロピル、イソプロピル、
ブチル、イソブチル)、プロピオン酸およびそのナトリ
ウム塩もしくはカルシウム塩、ジフェニル、オルトフェ
ニルフェノール並びにチアベンダゾールにほぼ限られ
る。2. Description of the Related Art Currently, in various fields, prevention of contamination or deterioration of products caused by microorganisms,
Various bactericides and preservatives are used as preservatives (or preservatives) to ensure the storability of products. Among these, in the field of products directly applied to or ingested by the living body, particularly in the fields of cosmetics, pharmaceuticals, foods, etc., in order to ensure the safety of the living body, the types and application amounts of preservatives that can be used Is often set. For example,
In the field of cosmetics, the preservatives are benzoic acid (0.2%), benzoates (1.0%), salicylic acid (0.2%), salicylates (1.0%), carboxylic acid (0.1%) according to the Ministry of Health and Welfare notification.
%), Sorbic acid and its salts (0.5%), dehydroacetic acid and its salts (0.5%), paraoxybenzoic acid ester (1.0%), parachlorometacresol (0.5%)
%), Bithionol (0.1%), hexachlorophene (0.1%), boric acid (0.5%) and resorcinol (0.1%)
%) (The maximum concentration used in parentheses), and these are also mandatory ingredients. In the field of pharmaceuticals,
Benzoic acid, sodium benzoate, benzalkonium chloride, benzethonium chloride, cresol, chlorobutanol, thymol, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, phenol and benzyl alcohol as preservatives It is listed in the Japanese Pharmacopoeia. Further, in the food field, substances having toxicity cannot be used, and benzoic acid and its sodium salt, sorbic acid and its potassium salt, dehydroacetic acid and its sodium salt, paraoxybenzoic acid and its ester are used as preservatives. (Ethyl, propyl, isopropyl,
Butyl, isobutyl), propionic acid and its sodium or calcium salts, diphenyl, orthophenylphenol and thiabendazole.
【0003】しかし、このように種類や使用量を限定し
たとしても、これらの物質の多くは本質的に皮膚や全身
性のアレルギーを引き起こすアレルゲンであり、これら
の物質を適用することによりアレルギーを引き起こす恐
れがある。また、刺激性であったり、毒性を有するもの
も多い。However, even if the kind and the amount used are limited, many of these substances are essentially allergens causing skin and systemic allergies, and application of these substances causes allergies. There is a fear. In addition, many of them are irritating or toxic.
【0004】そこで、このような殺菌剤や防腐剤を用い
ずに抗菌力を持たせる試みが従来なされており、例え
ば、アルコールを配合する方法、フェノキシエタノール
を配合する方法、抗菌性のポリオールを用いる方法、抗
菌性の動植物由来の成分や抽出物を用いる方法などが知
られている。また、一般に、pH 2.5以下の酸性領域と
pH10.5以上のアルカリ性領域では抗菌性が高まること
が知られており、実際、食品等の分野では酸性になるよ
うにpHを調整して防腐能力を高める技術が広く用いら
れている。Therefore, attempts have been made so far to impart antibacterial activity without using such bactericides and preservatives. For example, a method of blending alcohol, a method of blending phenoxyethanol, and a method of using antimicrobial polyol. A method using an antibacterial animal or plant-derived component or extract is known. In addition, it is generally known that the antibacterial property is enhanced in the acidic region of pH 2.5 or lower and the alkaline region of pH 10.5 or higher. Boosting techniques are widely used.
【0005】[0005]
【発明が解決しようとする課題】しかしながら、これら
アルコール、フェノキシエタノール、抗菌性ポリオー
ル、抗菌性抽出物等を配合する方法では十分な抗菌力を
得ることはできず、室温では使用途中で腐敗したり、カ
ビが生えたりする。このため、これらの方法を用いて製
造した組成物は、製造時に微生物が混入しないように無
菌製造を行なうと共に、微生物が混入しにくい容器や使
い捨てタイプの小容器に収容したり、開封後の冷蔵保存
や使用期間の短期限定等の方法によって抗菌力の不足に
対応している。However, the method of blending these alcohols, phenoxyethanol, antibacterial polyols, antibacterial extracts and the like cannot obtain sufficient antibacterial activity, and at room temperature, it may rot during use, Mold will grow. Therefore, the composition produced by using these methods, aseptic manufacturing so as not to be mixed with microorganisms at the time of manufacture, and stored in a container or a disposable type small container in which microorganisms are difficult to mix, refrigerated after opening. We cope with the lack of antibacterial activity by methods such as storage and short-term use.
【0006】また、組成物を酸性(pH 2.5以下)やア
ルカリ性(pH10.5以上)とする方法では、組成物に十
分な抗菌力を付与することが可能であるが、このような
組成物は生体、特に皮膚や粘膜に対する刺激が強く、特
殊な用途を除いて一般の組成物に適用することはできな
い。Further, a method of making the composition acidic (pH 2.5 or less) or alkaline (pH 10.5 or more) can impart sufficient antibacterial activity to the composition, but such a composition is It is highly irritating to the living body, especially the skin and mucous membranes, and cannot be applied to general compositions except for special applications.
【0007】したがって、この発明は、毒性や刺激性を
有していたり、アレルギーを引き起こすアレルゲンとな
るような、生体、特に人体に害を及ぼす可能性のある殺
菌剤や防腐剤を用いることなく、これら殺菌剤や防腐剤
を用いた場合と同等かそれ以上の抗菌力を長期間保持し
得る、低アレルギー性、低刺激性かつ低毒性の抗菌性組
成物を提供することを目的とする。Therefore, the present invention does not use a bactericidal agent or an antiseptic agent which is toxic or irritating, or which may be an allergen causing allergies, which may harm the living body, particularly the human body. It is an object of the present invention to provide a hypoallergenic, hypoallergenic, and low-toxicity antibacterial composition capable of retaining an antibacterial activity equivalent to or higher than those obtained by using these fungicides and preservatives for a long period of time.
【0008】[0008]
【課題を解決するための手段】本発明者は、上記事情に
鑑み、鋭意研究の結果、特定のpH条件の下で殺菌剤も
しくは防腐剤以外の抗菌性物質の少なくとも1種類を用
いるか、あるいは殺菌剤もしくは防腐剤以外の抗菌性物
質の少なくとも2種類を組み合わせて用いることにより
実用に足る十分な抗菌力を得ることが可能であることを
見出し、この発明をなすに至った。In view of the above circumstances, the present inventors have made earnest studies and, as a result, have used at least one antibacterial substance other than a bactericide or a preservative under a specific pH condition, or The inventors have found that it is possible to obtain a practically sufficient antibacterial activity by using at least two kinds of antibacterial substances other than bactericides or antiseptics in combination, and completed the present invention.
【0009】すなわち、この発明の一面における抗菌性
組成物は、pH調整剤および抗菌性物質からなる群より
選ばれる少なくとも2種類を含有する組成物であって、
前記pH調整剤は組成物のpHを 2.8ないし 7.0とする
ものであることを特徴とする。ここで用いられる抗菌性
物質は、好ましくはフェノキシエタノールおよび抗菌性
ポリオールである。That is, the antibacterial composition according to one aspect of the present invention is a composition containing at least two kinds selected from the group consisting of a pH adjuster and an antibacterial substance,
The pH adjuster is characterized in that the pH of the composition is 2.8 to 7.0. The antibacterial substances used here are preferably phenoxyethanol and antibacterial polyols.
【0010】また、この発明の他の面における抗菌性組
成物は、少なくとも1種の抗菌性物質を含有し、かつp
Hが 2.8ないし 7.0であることを特徴とする。An antibacterial composition according to another aspect of the present invention contains at least one antibacterial substance, and p
Characterized by H being 2.8 to 7.0.
【0011】ここで言う「抗菌性物質」とは、従来、香
粧品、医薬品、食品等の分野において広く用いられ、単
独で組成物に十分な抗菌力を付与することが可能ではあ
るものの、毒性や刺激性を有していたり、アレルギーを
引き起こすアレルゲンとなるような、生体、特に人体に
害を及ぼす可能性のある殺菌剤や防腐剤を除く抗菌性の
物質を指す。この発明においては、抗菌性物質は、天然
由来の物質または合成物質のいずれであってもよい。具
体的には、天然由来の抗菌性物質の例として、動物由来
の物質もしくは抽出物としてミツロウ、プロポリス、ロ
ーヤルゼリー、乳精、馬油、ヒドロキシ酢酸、キチン、
キトサン、ペプチド等を挙げることができ、また植物由
来の物質もしくは抽出物としてアロエ、オウゴン、オウ
セイ、オウバク、エンメイソウ、クジン、ゲンノショウ
コウ、サンザシ、サンシン、サンショウ、シコン、シ
ソ、ジュウヤク、ソウハクヒ、トウキ、ニンジン、ニン
ドウ、ニンニク、バクモンドウ、ビャクト、ビワ、モ
モ、ユキノシタ、レンギョウ、ログウッド、アルニカ、
オトギソウ、カミツレ、サルビア、シャクヤク、ショウ
ブ、シラカバ、セイヨウノコギリソウ、センキュウ、タ
イム、トウキンセンカ、ハマメリス、ホップ、ヨモギ、
カワラヨモギ、ラベンダー、レモンおよびローズマリー
の抽出物、カンゾウフラボノイド、α- ビサボロール、
ペプチド等を挙げることができる。また、合成抗菌性物
質の例としては、エタノール、イソプロパノール等の低
級アルコール、1,3-ブチレングリコール、ジプロピレン
グリコール、3-メチル-1,3- ブタンジオール等の抗菌性
ポリオール、フェノキシエタノール、α- ヒドロキシ酸
等を挙げることができる。この発明において好ましい抗
菌性物質は、抗菌性ポリオールまたはフェノキシエタノ
ールである。The term "antibacterial substance" as used herein is conventionally widely used in the fields of cosmetics, pharmaceuticals, foods, etc., and although it is possible to impart sufficient antibacterial activity to the composition by itself, it is toxic. It refers to an antibacterial substance excluding bactericides and preservatives, which have an irritating property or become an allergen that causes allergies, which may harm the living body, especially the human body. In the present invention, the antibacterial substance may be a naturally occurring substance or a synthetic substance. Specifically, as an example of a naturally derived antibacterial substance, beeswax, propolis, royal jelly, milk sperm, horse oil, hydroxyacetic acid, chitin, as an animal-derived substance or extract,
Chitosan, peptides and the like can be mentioned, and as a plant-derived substance or extract, aloe, sardine, eucalyptus, pearl oyster, neem grass, kujin, ginger ginger, hawthorn, sanshin, ginseng, shikon, perilla, sycamore, sowakuhi, touki. , Carrot, nindou, garlic, bakumondo, juniper, loquat, peach, yukinoshita, forsythia, logwood, arnica,
Hypericum, chamomile, salvia, peony, ginger, birch, yarrow, senkyu, thyme, quince, hamamelis, hop, mugwort,
Kawamurawoge, lavender, lemon and rosemary extract, licorice flavonoids, α-bisabolol,
Examples thereof include peptides. Examples of synthetic antibacterial substances include ethanol, lower alcohols such as isopropanol, antibacterial polyols such as 1,3-butylene glycol, dipropylene glycol, and 3-methyl-1,3-butanediol, phenoxyethanol, α- A hydroxy acid etc. can be mentioned. The preferred antibacterial substance in the present invention is an antibacterial polyol or phenoxyethanol.
【0012】これらの抗菌性物質の配合量は組成物の剤
形や処方によって異なり、抗菌力、安全性、感触、外
観、物性等を考慮して決定されるものであって一概に特
定できるものではないが、一般に、用いられる抗菌性物
質の合計で、組成物全体に対して 0.0101 〜 100.0重量
%である。また、個々の抗菌性物質については、組成物
全体に対して、ミツロウでは 0.1〜50.0、好ましくは
0.5〜 5.0重量%、プロポリスでは0.01〜99.9、好まし
くは 0.1〜10.0重量%、ローヤルゼリーでは0.01〜99.
9、好ましくは 0.1〜10.0重量%、乳精では 0.1〜99.
9、好ましくは 0.1〜50.0重量%、馬油では 0.1〜99.
9、 0.1〜99.0重量%、ペプチドでは0.01〜99.9、好ま
しくは 0.1〜99.0重量%、キチンでは0.01〜99.9、好ま
しくは 0.1〜99.0重量%、キトサンでは0.01〜99.9、好
ましくは 0.1〜99.0重量%、植物由来の各種抽出物では
0.01〜99.9、カンゾウフラボノイドでは0.0001〜 5.0、
好ましくは 0.001〜 1.0重量%、α- ビサボロールでは
0.1〜 2.0、好ましくは 0.1〜 1.0重量%、低級アルコ
ールでは 1.0〜99.9、好ましくは 2.0〜50.0重量%、抗
菌性ポリオールでは 1.0〜99.9、好ましくは 2.0〜50.0
重量%、フェノキシエタノールでは 0.1〜 5.0、好まし
くは 0.1〜 1.0重量%、α- ヒドロキシ酸では0.01〜2
0.0、好ましくは 0.01 〜 5.0重量%、pH調整剤では
0.01〜20.0、好ましくは0.01〜 5.0重量%である。The blending amount of these antibacterial substances differs depending on the dosage form and prescription of the composition, and is determined in consideration of antibacterial activity, safety, feel, appearance, physical properties, etc., and can be generally specified. However, the total amount of antibacterial substances used is generally 0.0101 to 100.0% by weight, based on the total composition. Further, for each antibacterial substance, beeswax is 0.1 to 50.0 with respect to the entire composition, preferably
0.5 to 5.0% by weight, 0.01 to 99.9 in propolis, preferably 0.1 to 10.0% by weight, 0.01 to 99 in royal jelly.
9, preferably 0.1-10.0% by weight, for milk semen 0.1-99.
9, preferably 0.1-50.0% by weight, for horse oil 0.1-99.
9, 0.1-99.0 wt%, 0.01-99.9, preferably 0.1-99.0 wt% for peptides, 0.01-99.9, preferably 0.1-99.0 wt% for chitin, 0.01-99.9 for chitosan, preferably 0.1-99.0 wt%, In various plant-derived extracts
0.01-99.9, licorice flavonoids 0.0001-5.0,
Preferably 0.001-1.0% by weight, for α-bisabolol
0.1-2.0, preferably 0.1-1.0 wt%, lower alcohol 1.0-99.9, preferably 2.0-50.0 wt%, antimicrobial polyol 1.0-99.9, preferably 2.0-50.0
% By weight, 0.1-5.0% by weight for phenoxyethanol, preferably 0.1-1.0% by weight, 0.01-2 for α-hydroxy acids.
0.0, preferably 0.01 to 5.0% by weight, for pH adjusters
It is 0.01 to 20.0, preferably 0.01 to 5.0% by weight.
【0013】この発明の抗菌性組成物は、上記抗菌性物
質から選ばれる少なくとも2種類の物質を含有するか、
もしくは上記抗菌性物質から選ばれる少なくとも1種類
の物質をpH 2.8〜 7.0の条件下に含有する。The antibacterial composition of the present invention contains at least two kinds of substances selected from the above antibacterial substances,
Alternatively, it contains at least one substance selected from the above antibacterial substances under the condition of pH 2.8 to 7.0.
【0014】この発明においては、組成物のpHを 2.8
〜 7.0とするために、pH調整剤を用いることができ
る。用いられるpH調整剤は、組成物のpHを 2.8〜
7.0、好ましくはpH 3.5〜 6.5に調整し得るものであ
ればどのようなものでもよく、各分野において通常用い
られるものを使用することができる。組成物のpHは上
記範囲内に収まっていればよいが、抗菌性の点からはよ
り低いほうが好ましい。この発明において用いられるp
H調整剤は、好ましくは無機酸もしくは有機酸またはそ
れらの塩であり、有機酸の例としてはクエン酸、グリコ
ール酸、コハク酸、酒石酸、乳酸、リンゴ酸、酪酸およ
びシュウ酸を、また無機酸の例としてはリン酸および塩
酸をそれぞれ挙げることができ、さらにこれらの酸のナ
トリウム塩、カリウム塩、カルシウム塩等を好適に用い
ることができる。特に好ましくは、pH調整剤はクエン
酸またはその塩である。In the present invention, the pH of the composition is 2.8.
A pH adjuster can be used to achieve ~ 7.0. The pH adjuster used has a composition pH of 2.8 to
Any one can be used as long as it can be adjusted to 7.0, preferably pH 3.5 to 6.5, and those usually used in each field can be used. The composition may have a pH within the above range, but it is preferably lower from the viewpoint of antibacterial property. P used in this invention
The H-adjusting agent is preferably an inorganic acid or an organic acid or a salt thereof, and examples of the organic acid include citric acid, glycolic acid, succinic acid, tartaric acid, lactic acid, malic acid, butyric acid and oxalic acid, and inorganic acid. Examples thereof include phosphoric acid and hydrochloric acid, and sodium salts, potassium salts, calcium salts and the like of these acids can be preferably used. Particularly preferably, the pH adjusting agent is citric acid or a salt thereof.
【0015】なお、上記抗菌性物質または組成物の処方
構成成分により組成物のpHが必然的に上記範囲内に収
まる場合には、特にpH調整剤を用いる必要はない。When the pH of the composition inevitably falls within the above range due to the antibacterial substance or the formulation constituents of the composition, it is not necessary to use a pH adjuster.
【0016】これらpH調整剤の配合量は、組成物のp
Hを 2.8〜 7.0に調整するに十分な量であればよく、組
成物の剤形、処方によって最適の配合量が決定される。
したがって、一概に特定できるものではないが、通常、
組成物全体に対して0.01〜 5.0重量%である。The blending amount of these pH adjusting agents is the p of the composition.
The amount may be a sufficient amount to adjust H to 2.8 to 7.0, and the optimum compounding amount is determined by the dosage form and formulation of the composition.
Therefore, although it cannot be specified unconditionally,
It is 0.01 to 5.0% by weight with respect to the entire composition.
【0017】この発明による抗菌性組成物においては、
上記成分のほかに、各分野で通常用いられるいかなる添
加物も添加することができるが、微生物の増殖を助長す
る成分は、組成物の抗菌力を損なわない程度にまで制限
することが好ましい。In the antibacterial composition according to the present invention,
In addition to the above-mentioned components, any additives usually used in each field can be added, but components that promote the growth of microorganisms are preferably limited to the extent that the antibacterial activity of the composition is not impaired.
【0018】この発明による抗菌性組成物の形態として
は、含水タイプ、粉末タイプ、固形粉末タイプ、オイル
タイプなどを挙げることができる。含水タイプの組成物
は、水を含むものであればどのようなものでもよく、例
えば、乳化タイプ、可溶化タイプ、溶液タイプ、分散タ
イプ、ゲルタイプを挙げることができる。Examples of the form of the antibacterial composition according to the present invention include water-containing type, powder type, solid powder type and oil type. The water-containing composition may be any composition as long as it contains water, and examples thereof include an emulsification type, a solubilization type, a solution type, a dispersion type and a gel type.
【0019】この発明による抗菌性組成物はいかなる分
野においても用いることができるが、特に香粧品、医薬
品、食品等の分野において、例えば基材や担体として好
適に用いることができる。また、微生物やアレルギーが
関与する疾患、例えば、ニキビ、フケ、ワキガ、炎症、
水虫、アトピー等の症状の改善に用いることもできる。
さらに、消毒や殺菌に用いることも可能である。The antibacterial composition according to the present invention can be used in any field, but particularly in the fields of cosmetics, pharmaceuticals, foods, etc., it can be preferably used as a base material or carrier. In addition, diseases related to microorganisms and allergies, such as acne, dandruff, armpits, inflammation,
It can also be used to improve symptoms such as athlete's foot and atopy.
Further, it can be used for disinfection and sterilization.
【0020】[0020]
【実施例】以下、この発明による抗菌性組成物を、実施
例に基づいてより詳細に説明する。EXAMPLES Hereinafter, the antibacterial composition according to the present invention will be described in more detail with reference to Examples.
【0021】実施例1〜5および比較例1〜3 下記表1に示す各組成のローションを下記A)に記す製
法に従って調製した。次に、得られたローションの抗菌
力を、大腸菌および黒コウジカビを用い、下記B)に記
す方法により測定した。その結果を表1に併記する。Examples 1 to 5 and Comparative Examples 1 to 3 Lotions having the respective compositions shown in Table 1 below were prepared according to the production method described in A) below. Next, the antibacterial activity of the obtained lotion was measured using E. coli and Aspergillus niger by the method described in B) below. The results are also shown in Table 1.
【0022】A)製法 表1に示す各組成の全成分を秤量し、約80℃に加熱して
均一に混合した後、冷却して検体とした。なお、操作は
無菌的に行なった。A) Manufacturing method All components of each composition shown in Table 1 were weighed, heated to about 80 ° C. and uniformly mixed, and then cooled to obtain a sample. The operation was performed aseptically.
【0023】B)抗菌力測定方法 (1) 大腸菌を用いた試験 前々培養36時間、前培養24時間および本培養 5時間を行
なうことにより 1コロニーから均質な菌体を得た。次い
で、この菌体を遠沈洗浄し、リン酸緩衝生理食塩水で 7
×108 [CFU]に調整して接種菌液とした。その後、
この接種菌液を上記A)で調製した各検体に 1%添加
し、37℃の水槽に保持して生菌数を経時的に測定した。B) Method for measuring antibacterial activity (1) Test using Escherichia coli Homogeneous cells were obtained from one colony by pre-preculture 36 hours, preculture 24 hours and main culture 5 hours. Then, the cells were washed by centrifugation and washed with phosphate buffered saline.
It was adjusted to × 10 8 [CFU] to give an inoculum solution. afterwards,
This inoculum solution was added to each sample prepared in A) above in an amount of 1% and kept in a water bath at 37 ° C to measure the viable cell count over time.
【0024】実施条件 前々培養・前培養 : SCDアガー、37℃ 本培養 : SCDブイヨン、50rpm rec
iprocal 、37℃ 供試菌株 : Escherichia coli IAM 12119 生菌数測定用培地 : SCDLPアガー 抗菌力の判定は、殺菌・防腐剤が配合された市販品のロ
ーション(複数)を基準とし、以下の通りに行なった。Preconditions Pre-preculture / preculture: SCD agar, 37 ° C main culture: SCD broth, 50 rpm rec
iprocal, 37 ° C Test strain: Escherichia coli IAM 12119 Viable count medium: SCDLP agar The antibacterial activity is determined based on the lotion (several) of a commercially available product containing a bactericidal / preservative agent as follows. I did.
【0025】 市販品と同等以上の抗菌力 : ◎ 市販品と同等の抗菌力 : ○ 市販品より低い抗菌力または菌が増殖するもの : × (2) 黒コウジカビを用いた試験 7日間の培養で得られた分生胞子を収穫し、0.01% Twee
n 80 添加生理食塩水中に分散した後濾過して 3×107
spore/mlに調整したものを接種菌液とした。この接
種菌液を上記A)で調製した各検体に 1%添加し、27℃
インキュベーターに保持して生菌数を経時的に測定する
と共に菌糸の繁殖を観察した。Antibacterial activity equal to or higher than that of the commercial product: ◎ Antibacterial activity equivalent to that of the commercial product: ○ Antibacterial activity lower than that of the commercial product or bacteria growing: × (2) Test using black mold The conidia obtained are harvested and 0.01% Twee
n 80 3 Dispersed in physiological saline, filtered, and filtered 3 × 10 7
The inoculum solution was adjusted to spore / ml. Add 1% of this inoculum to each sample prepared in A) above,
The cells were kept in an incubator to measure the viable cell count over time and the growth of hyphae was observed.
【0026】実施条件 胞子形成培地 : MY培地 供試菌株 : Aspergillus niger IFO 4407 生菌数測定用培地 : GPLPアガー 抗菌力の判定は、殺菌・防腐剤が配合された市販品のロ
ーション(複数)を基準とし、以下の通りに行なった。Implementation conditions Sporulation medium: MY medium Test strain: Aspergillus niger IFO 4407 Medium for viable cell count: GPLP agar To determine the antibacterial activity, use lotion (s) of a commercial product containing a bactericidal / preservative agent. As a reference, the procedure was as follows.
【0027】 市販品と同等以上の抗菌力 : ◎ 市販品と同等の抗菌力 : ○ 抗菌性はあるが、市販品より劣るもの : △ 抗菌性がなく、菌が発芽・増殖するもの : ×Antibacterial activity equal to or higher than commercial products: ◎ Antibacterial activity equivalent to commercial products: ○ Antibacterial properties, but inferior to commercial products: △ No antibacterial properties, germs germinate and multiply: ×
【表1】 表1から明らかなように、この発明による抗菌性組成物
は、大腸菌および黒コウジカビのいずれに対しても殺菌
・防腐剤が配合された市販品と同等以上の優れた抗菌力
を示している。これに対し、比較例の組成物はいずれも
十分な抗菌力が得られず、市販に耐え得るレベルのもの
ではなかった。[Table 1] As is clear from Table 1, the antibacterial composition according to the present invention exhibits superior antibacterial activity to both E. coli and Aspergillus niger, which is equal to or higher than that of a commercial product containing a bactericidal / preservative. On the other hand, none of the compositions of Comparative Examples had a sufficient antibacterial activity and were not at a level that could withstand commercial use.
【0028】実施例6 下記処方のクリームを下記製法に従って調製した。Example 6 A cream having the following formulation was prepared according to the following production method.
【0029】 処 方 配合量 (重量%) −−−−−−−−−−−−−−−−−−−−−−−− −−−−− (1) ミツロウ 5.0 (2) ベヘニルアルコール 4.0 (3) 流動パラフィン 20.0 (4) モノステアリン酸グリセリン 5.0 (5) ポリオキシエチレンモノステアリン酸ソルビタン 3.0 (6) フェノキシエタノール 0.5 (7) クエン酸 0.02 (8) 1,3-ブチレングリコール 7.0 (9) 精製水 55.48 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− pH 3.8 製法) (i) 上記処方の (1)〜 (6)を75℃で加熱溶解する。Treatment Mixing amount (% by weight) ------------------------------ (1) Beeswax 5.0 (2) Behenyl alcohol 4.0 (3) Liquid paraffin 20.0 (4) Glycerin monostearate 5.0 (5) Polyoxyethylene sorbitan monostearate 3.0 (6) Phenoxyethanol 0.5 (7) Citric acid 0.02 (8) 1,3-Butylene glycol 7.0 (9) Purified water 55.48 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− --- pH 3.8 manufacturing method) (i) (1) to (6) of the above formulation are heated and dissolved at 75 ° C.
【0030】(ii) (i) とは別に上記処方の (7)〜 (9)
を75℃で加熱溶解する。(Ii) (7) to (9) of the above formulation separately from (i)
Is melted by heating at 75 ° C.
【0031】(iii) 上記 (i)の調製物に (ii) の調製物
を加えて乳化・冷却する。(Iii) The preparation of (ii) is added to the preparation of (i) above, and the mixture is emulsified and cooled.
【0032】実施例7 下記処方の美容液を下記製法に従って調製た。Example 7 A beauty essence having the following formulation was prepared according to the following production method.
【0033】 処 方 配合量 (重量%) −−−−−−−−−−−−− −−−−− (1) 植物抽出液 1.0 (2) ソルビット 3.0 (3) グリセリン 3.0 (4) ヒアルロン酸ナトリウム 0.03 (5) キサンタンガム 1.0 (6) フェノキシエタノール 0.4 (7) クエン酸 0.2 (8) 1,3-ブチレングリコール 10.0 (9) 精製水 81.37 −−−−−−−−−−−−−−−−−−−−−−−−−− pH 4.8 製法) (i) 上記処方の (1)〜 (3)および (6)〜 (9)を70℃で
加熱・溶解する。Treatment Mixing amount (% by weight) ----------------------- (1) Plant extract 1.0 (2) Sorbit 3.0 (3) Glycerin 3 .0 (4) sodium hyaluronate 0.03 (5) xanthan gum 1.0 (6) phenoxyethanol 0.4 (7) citric acid 0.2 (8) 1,3-butylene glycol 10.0 (9) purified water 81.37 −−−−−−−−−−−−−−−−−−−−−−−−−− pH 4.8 Manufacturing method) (i) (1) to (3) and (3) of the above formulation. 6)-(9) are heated and melted at 70 ℃.
【0034】(ii) 上記処方の (4)および (5)を撹拌し
ながら (i)の調製物に加えて均一に溶解し、冷却する。(Ii) (4) and (5) of the above formulation are added to the preparation of (i) with stirring, uniformly dissolved, and cooled.
【0035】実施例8 下記処方の洗浄料を下記製法に従って調製した。Example 8 A cleaning agent having the following formulation was prepared according to the following production method.
【0036】 処 方 配合量 (重量%) −−−−−−−−−−−−−−−−−−−−−− −−−−− (1) ラウロイル-L- グルタミン酸トリエタノール 60.0 (2) ヤシ油脂肪酸アミドプロピルベタイン 10.0 (3) アラントイン 0.1 (4) クエン酸 0.3 (5) フェノキシエタノール 0.5 (6) 精製水 29.1 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−− pH 5.3 製法)上記処方の (1)〜 (7)を室温で撹拌して均一に溶
解する。Method Blending amount (% by weight) --------------------------- (1) Lauroyl-L-Glutamic acid triethanol 60. 0 (2) Coconut oil fatty acid amide propyl betaine 10.0 (3) Allantoin 0.1 (4) Citric acid 0.3 (5) Phenoxyethanol 0.5 (6) Purified water 29.1 -------- -------------------------------- pH 5.3 Manufacturing method) (1) to (7) of the above formulation are stirred at room temperature to uniformly dissolve.
【0037】実施例9 下記処方のジェルを下記製法に従って調製した。Example 9 A gel having the following formulation was prepared according to the following production method.
【0038】 処 方 配合量 (重量%) −−−−−−−−−−−−−−−−−−−− −−−−− (1) カルボキシビニルポリマー( 1% aq.) 60.0 (2) コラーゲン( 0.3%) 2.0 (3) ヒアルロン酸ナトリウム( 1%) 5.0 (4) アラントイン 0.1 (5) 植物抽出液 3.0 (6) フェノキシエタノール 0.4 (7) 1,3-ブチレングリコール 10.0 (8) 精製水 19.5 −−−−−−−−−−−−−−−−−−−−−−−−−−−−− pH 6.3 製法)上記処方の (1)〜 (8)を撹拌して均一に溶解す
る。Method Mixing amount (% by weight) ------------------ (1) Carboxyvinyl polymer (1% aq.) 60. 0 (2) Collagen (0.3%) 2.0 (3) Sodium hyaluronate (1%) 5.0 (4) Allantoin 0.1 (5) Plant extract 3.0 (6) Phenoxyethanol 0.4 (7) ) 1,3-Butylene glycol 10.0 (8) Purified water 19.5 ------------------------------ pH 6. 3 Manufacturing method) (1) to (8) of the above formulation are stirred and uniformly dissolved.
【0039】実施例10 下記処方のクリームを下記製法に従って調製した。Example 10 A cream having the following formulation was prepared according to the following production method.
【0040】 処 方 配合量 (重量%) −−−−−−−−−−−−−−−−−−−−−−−− −−−−− (1) ミツロウ 5.0 (2) ベヘニルアルコール 4.0 (3) 吸着精製ラノリン 15.0 (4) 流動パラフィン 25.0 (5) ステアリン酸ナトリウム 5.0 (6) ポリオキシエチレンモノステアリン酸ソルビタン 3.0 (7) 1,3-ブチレングリコール 7.0 (8) 精製水 36.0 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− pH 4.0 製法) (i) 上記処方の (1)〜 (6)を75℃で加熱溶解する。Treatment Mixing amount (% by weight) ------------------------------------- (1) Beeswax 5.0 (2) Behenyl alcohol 4.0 (3) Adsorption purified lanolin 15.0 (4) Liquid paraffin 25.0 (5) Sodium stearate 5.0 (6) Polyoxyethylene sorbitan monostearate 3.0 (7) 1,3- Butylene glycol 7.0 (8) Purified water 36.0 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−− pH 4.0 Manufacturing method (I) (1) to (6) of the above formulation are heated and dissolved at 75 ° C.
【0041】(ii) (i) とは別に上記処方の (7)および
(8)を75℃で加熱溶解する。(Ii) Apart from (i), (7) and
(8) is melted by heating at 75 ° C.
【0042】(iii) (i) の調製物に (ii) の調製物を加
えて乳化、冷却する。(Iii) The preparation of (ii) is added to the preparation of (i), and the mixture is emulsified and cooled.
【0043】実施例11 下記処方のミルクローションを下記製法に従って調製し
た。Example 11 A milk lotion having the following formulation was prepared according to the following method.
【0044】 処 方 配合量 (重量%) −−−−−−−−−−−−−−−−−−−−−−−− −−−−− (1) ステアリン酸 4.0 (2) ベヘニルアルコール 4.0 (3) 流動パラフィン 5.0 (4) ステアリン酸モノグリセリン 4.0 (5) ポリオキシエチレンモノステアリン酸ソルビタン 2.0 (6) フェノキシエタノール 0.3 (7) クエン酸 0.1 (8) クエン酸ナトリウム 0.1 (9) 1,3-ブチレングリコール 6.0 (10)精製水 74.5 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− pH 4.6 製法) (i) 上記処方の (1)〜 (6)を75℃で加熱溶解する。Treatment Mixing amount (% by weight) ------------------------------ (1) Stearic acid 4.0 (2) ) Behenyl alcohol 4.0 (3) Liquid paraffin 5.0 (4) Monoglycerin stearate 4.0 (5) Polyoxyethylene sorbitan monostearate 2.0 (6) Phenoxyethanol 0.3 (7) Citric acid 0.0. 1 (8) Sodium citrate 0.1 (9) 1,3-butylene glycol 6.0 (10) Purified water 74.5 −−−−−−−−−−−−−−−−−−−−−− --------------- pH 4.6 Manufacturing Method) (i) (1) to (6) of the above formulation are heated and dissolved at 75 ° C.
【0045】(ii) (i) とは別に、上記処方の (7)〜(1
0)を75℃で加熱溶解する。(Ii) In addition to (i), (7) to (1
0) is heated and melted at 75 ° C.
【0046】(iii) (i) の調製物に (ii) の調製物を加
えて乳化、冷却する。(Iii) The preparation of (ii) is added to the preparation of (i), and the mixture is emulsified and cooled.
【0047】上記実施例6〜11において調製した美容
液、洗浄料、ジェル、クリームおよびミルクローション
の抗菌力を、上記実施例1および2と同様の方法で判定
した。その結果を下記表2に示す。The antibacterial activity of the beauty essences, detergents, gels, creams and milk lotions prepared in Examples 6 to 11 was determined in the same manner as in Examples 1 and 2 above. The results are shown in Table 2 below.
【0048】 表 2 実 施 例 −−−−−−−−−−−−−−−−−− 6 7 8 9 10 11 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 大腸菌に対する抗菌力 ○ ◎ ○ ○ ○ ◎ 黒コウジカビに対する抗菌力 ◎ ◎ ◎ ◎ ○ ◎ 表2より明らかなように、この発明による抗菌性組成物
は、大腸菌および黒コウジカビのいずれに対しても殺菌
・防腐剤が配合された市販品と同等以上の優れた抗菌力
を示す。また、これらの組成物は、この他にも緑膿菌、
黄色ブドウ球菌および枯草菌に対しても優れた抗菌力を
示す。Table 2 Actual Example -------------------------------- 6 7 8 9 10 11 -------------------- −−−−−−−−−−−−−−− Antibacterial activity against E. coli ○ ◎ ○ ○ ○ ◎ Antibacterial activity against Aspergillus niger ◎ ◎ ◎ ◎ ○ ○ ◎ As is clear from Table 2, the antibacterial composition according to the present invention. The product shows excellent antibacterial activity equivalent to or higher than that of a commercial product containing a sterilizing / preservative agent against both Escherichia coli and Aspergillus niger. In addition, these compositions also include Pseudomonas aeruginosa,
Excellent antibacterial activity against Staphylococcus aureus and Bacillus subtilis.
【0049】[0049]
【発明の効果】以上のように、この発明によると、低ア
レルギー、低刺激性かつ低毒性の抗菌性組成物が提供さ
れる。この抗菌性組成物は、毒性や刺激性を有していた
り、アレルギーを引き起こすアレルゲンとなるような、
生体に害を及ぼす可能性のある従来の殺菌剤や防腐剤を
用いることなく、十分な抗菌力を発揮する。As described above, according to the present invention, a hypoallergenic, hypoallergenic and low-toxicity antibacterial composition is provided. This antibacterial composition has toxicity or irritation, or becomes an allergen that causes allergies,
It exerts sufficient antibacterial activity without the use of conventional bactericides and preservatives that may harm the living body.
【0050】この発明による抗菌性組成物は、香粧品、
医薬品、食品等に好適に用いることができ、特に香粧品
に用いた場合には、厚生省告示によって定められ、かつ
表示義務を有する殺菌・防腐剤を含有せずに十分な抗菌
力を得ることができるため、「無添加化粧品」と称する
ことが可能であり、しかも使用期限、用いる容器、冷蔵
保存の必要性など無添加に伴う制約を受けることがな
い。The antibacterial composition according to the present invention is a cosmetic product,
It can be suitably used for medicines, foods, etc., and particularly when used for cosmetics, it is possible to obtain sufficient antibacterial activity without containing a sterilizing / preservative agent that is stipulated by the Ministry of Health and Welfare notification and has a labeling obligation. Therefore, it can be referred to as "additive-free cosmetics", and is not subject to restrictions such as expiration date, container to be used, need for refrigerated storage, and the like.
Claims (3)
り選ばれる少なくとも2種類の物質を含有する抗菌性組
成物であって、該pH調整剤は該組成物のpHを 2.8な
いし7.0とするものである抗菌性組成物。1. An antibacterial composition containing at least two kinds of substances selected from the group consisting of a pH adjusting agent and an antibacterial substance, wherein the pH adjusting agent adjusts the pH of the composition to 2.8 to 7.0. An antibacterial composition which is
つそのpHが 2.8ないし 7.0である抗菌性組成物。2. An antibacterial composition containing at least one antibacterial substance and having a pH of 2.8 to 7.0.
抗菌性ポリオールからなる群より選ばれる少なくとも2
種類の物質を含有する抗菌性組成物であって、該pH調
整剤は該組成物のpHを 2.8ないし 7.0とするものであ
る抗菌性組成物。3. At least 2 selected from the group consisting of pH adjusters, phenoxyethanol and antibacterial polyols.
An antibacterial composition containing different types of substances, wherein the pH adjuster adjusts the pH of the composition to 2.8 to 7.0.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12635894A JPH07330505A (en) | 1994-06-08 | 1994-06-08 | Antimicrobial composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12635894A JPH07330505A (en) | 1994-06-08 | 1994-06-08 | Antimicrobial composition |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH07330505A true JPH07330505A (en) | 1995-12-19 |
Family
ID=14933211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12635894A Pending JPH07330505A (en) | 1994-06-08 | 1994-06-08 | Antimicrobial composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH07330505A (en) |
Cited By (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0920630A (en) * | 1995-07-06 | 1997-01-21 | Nippon Zetotsuku Kk | Cosmetic material |
JPH0952814A (en) * | 1995-08-09 | 1997-02-25 | Sunstar Inc | Skin cosmetic composition |
JPH09255518A (en) * | 1996-03-19 | 1997-09-30 | Noevir Co Ltd | Antibacterial low irritating cosmetic material |
JPH09255519A (en) * | 1996-03-19 | 1997-09-30 | Noevir Co Ltd | Antibacterial low irritating cosmetic material |
JPH09255517A (en) * | 1996-03-19 | 1997-09-30 | Noevir Co Ltd | Antibacterial low irritating cosmetic material |
JPH1045562A (en) * | 1996-08-08 | 1998-02-17 | Noevir Co Ltd | Antimicrobial and low-irritant cosmetic |
JPH1045556A (en) * | 1996-08-02 | 1998-02-17 | Noevir Co Ltd | Antimicrobial and low-irritant cosmetic |
JPH1053510A (en) * | 1996-05-27 | 1998-02-24 | Shiseido Co Ltd | Composition for external use |
JPH10139601A (en) * | 1996-11-13 | 1998-05-26 | Noevir Co Ltd | Antimicrobial and antimicrobial cosmetic material containing the same |
JPH10175842A (en) * | 1996-12-13 | 1998-06-30 | Noevir Co Ltd | Skin preparation for external use |
JPH10194948A (en) * | 1997-01-17 | 1998-07-28 | Nippon Shizen Shokuhin Kk | Skin lotion |
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JPH1180781A (en) * | 1997-09-11 | 1999-03-26 | Narisu Keshohin:Kk | Detergent composition for atopic dermatitis |
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JPH11228325A (en) * | 1998-02-17 | 1999-08-24 | Hiromi Nishii | Liquid agent composition compounded with plant extract |
JPH11279023A (en) * | 1998-03-30 | 1999-10-12 | Shiseido Co Ltd | Composition for external use |
JPH11302147A (en) * | 1998-04-17 | 1999-11-02 | Nippon Zetokku Kk | Cosmetic |
JPH11335258A (en) * | 1998-05-19 | 1999-12-07 | Fancl Corp | Cosmetic |
JP2000273004A (en) * | 1999-03-19 | 2000-10-03 | Nicca Chemical Co Ltd | Germicidal disinfectant composition |
JP2001048800A (en) * | 1999-08-05 | 2001-02-20 | Mitsui Norin Co Ltd | Antifungal agent effective to fungus resistant to medicine and low acidic drink containing the same and method for producing the drink |
JP2001206816A (en) * | 1999-11-19 | 2001-07-31 | Frontier:Kk | Milky lotion having skin-softening property and antimicrobial activity, cosmetic preparation and skin- cleansing article |
JP2002504114A (en) * | 1997-06-04 | 2002-02-05 | ザ、プロクター、エンド、ギャンブル、カンパニー | Antibacterial, mild rinse-off liquid cleaning composition |
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-
1994
- 1994-06-08 JP JP12635894A patent/JPH07330505A/en active Pending
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JPH10203991A (en) * | 1997-01-20 | 1998-08-04 | Noevir Co Ltd | Preparation for external use for skin |
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JP2002504114A (en) * | 1997-06-04 | 2002-02-05 | ザ、プロクター、エンド、ギャンブル、カンパニー | Antibacterial, mild rinse-off liquid cleaning composition |
JPH1180781A (en) * | 1997-09-11 | 1999-03-26 | Narisu Keshohin:Kk | Detergent composition for atopic dermatitis |
JPH11217211A (en) * | 1998-01-30 | 1999-08-10 | Shiseido Co Ltd | Sol composition |
JPH11228325A (en) * | 1998-02-17 | 1999-08-24 | Hiromi Nishii | Liquid agent composition compounded with plant extract |
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JPH11335258A (en) * | 1998-05-19 | 1999-12-07 | Fancl Corp | Cosmetic |
JP2000273004A (en) * | 1999-03-19 | 2000-10-03 | Nicca Chemical Co Ltd | Germicidal disinfectant composition |
JP2001048800A (en) * | 1999-08-05 | 2001-02-20 | Mitsui Norin Co Ltd | Antifungal agent effective to fungus resistant to medicine and low acidic drink containing the same and method for producing the drink |
JP2001206816A (en) * | 1999-11-19 | 2001-07-31 | Frontier:Kk | Milky lotion having skin-softening property and antimicrobial activity, cosmetic preparation and skin- cleansing article |
JP2002316922A (en) * | 2001-04-16 | 2002-10-31 | Magunooru:Kk | Skin cleansing agent containing extract from aralia cordata |
JP2003081759A (en) * | 2001-09-13 | 2003-03-19 | Shiseido Co Ltd | Water-in-oil emulsified composition |
JP2002223734A (en) * | 2002-01-21 | 2002-08-13 | Mitsui Norin Co Ltd | Low-acid drink containing antifungal agent effective on drug-resistant eumycetes and method for producing the same |
WO2006067875A1 (en) * | 2004-12-22 | 2006-06-29 | Yamachu Co., Ltd. | Anti-uv aqueous cosmetic composition |
JP2006249049A (en) * | 2005-03-14 | 2006-09-21 | Shiseido Co Ltd | Skin care composition |
JPWO2007015453A1 (en) * | 2005-08-01 | 2009-02-19 | マルホ株式会社 | Lotion containing a pyridonecarboxylic acid derivative |
US8778965B2 (en) | 2005-08-01 | 2014-07-15 | Maruho Co., Ltd. | Lotion preparation containing pyridonecarboxylic acid derivative |
JP2008100923A (en) * | 2006-10-17 | 2008-05-01 | Kao Corp | Antiseptic germicide and skin care external composition |
WO2008065734A1 (en) * | 2006-11-27 | 2008-06-05 | Oct Incorporated | Aqueous composition |
KR20100051450A (en) * | 2008-11-07 | 2010-05-17 | (주)아모레퍼시픽 | Mild composition for skin external application under the weak acid conditions |
KR20160058780A (en) | 2013-09-25 | 2016-05-25 | 다이헤이요 세멘토 가부시키가이샤 | Method for producing metal hydride |
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