JP2000273004A - Germicidal disinfectant composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition reduced in irritation to the skin in use and remarkably improved in feeling after use while maintaining its excellent germicidal disinfectant power, by including a quaternary ammonium salt- based germicidal disinfectant or biguanide-based germicidal disinfectant. SOLUTION: This germicidal disinfectant composition is obtained by formulating 0.01-2 wt.% of a polyalkylene glycol or a derivative of an alkylene glycol each having a coagulation point of >=35 deg.C in a lower alcohol solution of a quatentary ammonium salt-based germicidal disinfectant or a biguanide-based germicidal disinfectant. This composition is desirable to be adjusted to pH 4 to 8 using a carboxylic acid or a salt thereof.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a disinfectant composition. More specifically, the present invention provides a quaternary ammonium salt-based disinfectant or a biguanide-based disinfectant that reduces skin irritation during use and significantly improves the feel after use while maintaining excellent disinfectant power. And a disinfectant composition containing the same.

[0002]

2. Description of the Related Art In recent years, a medical institution has been used a preparation obtained by adding a quaternary ammonium salt-based disinfectant or a biguanide-based disinfectant to an aqueous alcohol solution. However, since the alcohol used as a solvent has a high degreasing power, the skin surface has a rough skin, furthermore, skin irritation caused by the disinfectant and disinfectant, and an unpleasant touch such as a sticky feeling and stickiness due to the residual disinfectant on the skin surface. Many have occurred. For this reason, a germicidal disinfectant composition having reduced irritancy to the skin and improved tactile sensation after use while maintaining the excellent germicidal disinfectant of the quaternary ammonium salt-based disinfectant or biguanide-based disinfectant. Is required.

[0003]

DISCLOSURE OF THE INVENTION The present invention provides a quaternary ammonium salt-based disinfectant or disinfectant that has reduced skin irritation during use and markedly improved tactile sensation after use while maintaining excellent disinfectant power. An object of the present invention is to provide a disinfectant composition containing a biguanide disinfectant.

[0004]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to solve the above problems, and as a result, have found that a quaternary ammonium salt-based disinfectant or a biguanide-based disinfectant can be used in a lower alcohol solution. By blending a polyalkylene glycol having a freezing point of 35 ° C. or more or a derivative of an alkylene glycol having a freezing point of 35 ° C. or more, the feel after use is improved, and the pH is adjusted to 4 to 4 using a carboxylic acid or a salt thereof. By adjusting to 8, it was found that irritation to the skin could be reduced, and the present invention was completed based on this finding. That is, the present invention provides (1)
The freezing point of a quaternary ammonium salt disinfectant or biguanide disinfectant in a lower alcohol solution is 3
Polyalkylene glycol having a temperature of 5 ° C. or higher or a freezing point of 35
A derivative of an alkylene glycol having a temperature of at least
% By weight, and (2) a carboxylic acid or a carboxylate,
It is intended to provide the disinfectant composition according to the above (1), wherein the pH is adjusted to 4 to 8. Further, as a preferred embodiment of the present invention, the content of (3) a quaternary ammonium salt-based disinfectant or a biguanide-based disinfectant is 0.01.
The disinfectant / disinfectant composition according to item (1), which is from 1 to 1% by weight,
(4) The lower alcohol solution is a lower alcohol aqueous solution having a lower alcohol concentration of 45 to 95% by weight.
(1) the disinfectant composition according to (1), (5) the disinfectant composition according to (1), wherein the molecular weight of the polyalkylene glycol is 1,000 or more; and (6) carboxylic acid or carboxylic acid. The germicidal disinfectant composition according to item (2), wherein the pH is adjusted to 5.0 to 7.5 with an acid salt.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The disinfectant composition of the present invention contains a quaternary ammonium salt disinfectant or a biguanide disinfectant as an active ingredient. There is no particular limitation on the quaternary ammonium-based disinfectant used in the composition of the present invention, and examples thereof include benzalkonium chloride, cetylpyridinium chloride, benzethonium chloride and the like. The biguanide-based germicidal disinfectant used in the composition of the present invention is not particularly limited, and examples thereof include chlorhexidine gluconate, chlorhexidine hydrochloride, and polyhexamethylene biguanide hydrochloride. In the composition of the present invention, the content of the quaternary ammonium salt-based disinfectant or biguanide-based disinfectant is preferably 0.01 to 1% by weight, and is 0.05 to 0.5% by weight. Is more preferable. When the content of the quaternary ammonium salt-based disinfectant or biguanide-based disinfectant is less than 0.01% by weight, the disinfecting and disinfecting power of the disinfecting and disinfecting composition may be insufficient. If the content of the quaternary ammonium salt-based disinfectant or biguanide-based disinfectant exceeds 1% by weight, an unpleasant touch may occur after use. In the composition of the present invention, the quaternary ammonium salt disinfectant and the biguanide disinfectant can be used alone or in combination. Further, the quaternary ammonium salt-based disinfectant and the biguanide-based disinfectant can be used alone or in combination of two or more. Examples of the lower alcohol used in the composition of the present invention include ethanol and isopropanol. Ethanol and isopropanol are prescribed in the Japanese Pharmacopoeia, so that ethanol or isopropanol is preferably used. In the composition of the present invention, purified water can be further added to the lower alcohol, if necessary, to obtain a lower alcohol aqueous solution. When the solvent is a lower alcohol aqueous solution, the concentration of the lower alcohol in the solvent is preferably 45 to 95% by weight, more preferably 65 to 90% by weight. By using a lower alcohol aqueous solution as the solvent, it is possible to reduce irritation to the skin and improve the feeling of use.

In the composition of the present invention, a polyalkylene glycol having a freezing point of 35 ° C. or higher or an alkylene glycol having a freezing point of 35 ° C. or higher is used in a lower alcohol solution of a quaternary ammonium salt-based disinfectant or a biguanide-based disinfectant. A glycol derivative is incorporated in an amount of 0.01 to 2% by weight, more preferably 0.05 to 1% by weight. As the polyalkylene glycol to be blended, for example, polyethylene glycol (coagulation point 35-100 ° C.), polyoxyethylene polyoxypropylene glycol (coagulation point 35-10
0 ° C.) and polyoxyethylene polyoxytetramethylene glycol (freezing point 35-100 ° C.). The alkylene glycol derivative to be blended in the composition of the present invention is a compound having a residue such as a monomer, dimer, trimer, oligomer, or polymer of alkylene glycol, and is not particularly limited as long as its freezing point is 35 ° C. or higher. Such derivatives include higher alkyl ethers such as stearyl alcohol, higher alkenyl ethers such as oleyl alcohol, ethers with polyhydric alcohols such as glycerin and sorbitol, lower alkyl ethers such as methanol, and sterol ethers such as cholesterol. Type compounds, monoesters or diesters of higher fatty acids, monoesters or diesters of lower fatty acids such as acetic acid, ether ester type compounds such as monoesters or diesters of alkenyl fatty acids, ester compounds of the above ether type compounds with lower or higher fatty acids , Alkyl carboxy glyceryl ethers or polyalkylene glyceryl alkylates of polyalkylene glycols, such as polyalkylene glycol adducts of hydrogenated castor oil Such as theft acids can be mentioned. For lower alcohol solutions of quaternary ammonium salt disinfectants or biguanide disinfectants,
By blending a polyalkylene glycol having a freezing point of 35 ° C. or higher or a derivative of an alkylene glycol having a freezing point of 35 ° C. or higher, when using a germicidal disinfectant composition,
No irritating skin irritation, no unpleasant tactile sensation after use
A very good feeling of smoothness can be obtained.
If the freezing point of the polyalkylene glycol or the derivative of the alkylene glycol to be blended is lower than 35 ° C., a sticky feeling or a sticky feeling may occur after use. When the blending amount of the polyalkylene glycol or the derivative of the alkylene glycol is less than 0.01% by weight, a feeling of niche may occur after use. If the amount of the polyalkylene glycol or the derivative of the alkylene glycol exceeds 2% by weight, a slimy feeling may be caused after use.

[0007] The composition of the present invention is preferably adjusted to a pH of 4 to 8 with a carboxylic acid or a carboxylate, and more preferably adjusted to a pH of 5.0 to 7.5. pH 4 ~
By adjusting to 8, the irritation to the skin of the germicidal disinfectant composition is reduced, and
Unpleasant tactile sensations such as stickiness can be reduced.
As the carboxylic acid used for pH adjustment, for example, acetic acid,
Tartaric acid, maleic acid, benzoic acid, gluconic acid, salicylic acid, malic acid, lactic acid, citric acid, pyrrolidone carboxylic acid, glycyrrhizic acid, glycyrrhetinic acid, edetic acid, and the like. Examples thereof include ammonium salts, lithium salts, sodium salts, and potassium salts of carboxylic acids. Among these, malic acid, lactic acid, citric acid, pyrrolidonecarboxylic acid and its salts, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, edetic acid and its salts can be particularly preferably used. In the composition of the present invention,
If necessary, additives such as a humectant, a wetting agent, and a surfactant can be added. Such additives include:
For example, N-cocoyl-L-arginine ethyl ester-DL-pyrrolidonecarboxylate may be used. The method for producing the germicidal disinfectant composition of the present invention is not particularly limited. For example, a quaternary ammonium salt germicidal disinfectant or a biguanide germicidal disinfectant is 0.01 to 1% by weight, a lower alcohol is 45 to 95% by weight, It can be produced by mixing 0.01 to 2% by weight of a polyalkylene glycol or a derivative of an alkylene glycol with other additives to be added as needed, and adding purified water until a constant volume is reached. If necessary, the pH can be adjusted to 4 to 8 with a carboxylic acid or a carboxylic acid salt. There is no particular limitation on the method of using the germicidal disinfectant composition of the present invention. For example, the germicidal composition can be supplied to a finger using a conventionally known spray, hand pump or the like. Usually, the composition 1 of the present invention
It can be applied by spreading 10 ml to fingers and rubbing well for 10 seconds to 2 minutes. If necessary,
This operation can be performed several times. By effectively rubbing the composition of the present invention over the entire finger, effective sterilization and disinfection can be performed.

[0008]

EXAMPLES The present invention will be described in more detail with reference to the following Examples, which should not be construed as limiting the present invention. The concentrated benzalkonium chloride solution 50 (Europe) used in Examples and Comparative Examples contains 50.0 to 55.0% by weight of benzalkonium chloride,
The chlorhexidine gluconate solution (Europe) contains 19.0 to 21.0% w / v of chlorhexidine gluconate. COMPARATIVE EXAMPLE 1 To 0.4 g of concentrated benzalkonium chloride solution (pharmacopoeia), 83 ml of pharmacopoeial ethanol was added, and water was further added to adjust the total amount to 1.
The drug was prepared in a volume of 00 ml. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, an unpleasant tactile sensation was left. Comparative Example 2 To 1 ml of chlorhexidine gluconate solution (pharmacopoeia), 83 ml of pharmacological ethanol was added, and water was further added to bring the total amount to 100 ml.
The drug was prepared as ml. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, an unpleasant tactile sensation was left. Example 1 To 0.4 g of concentrated benzalkonium chloride solution (pharmacopoeia), 83 ml of pharmacological ethanol and macrogol 6000 (pharmacopoeia)
(Polyethylene glycol, molecular weight 8,300, freezing point 58 ° C) 0.1 g was added, and water was further added to make the total amount 10
The drug was prepared as 0 ml. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, a good touch with a smooth feeling was obtained. Example 2 In 0.4 g of concentrated benzalkonium chloride solution (pharmacopoeia), 83 ml of pharmacological ethanol, macrogol 6000 (pharmacopoeia)
0.1 g and ethylenediaminetetraacetic acid disodium salt 0.1
The drug was prepared by adding 013 g and further adding water to make the total volume 100 ml. The pH of the drug was 6.5. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, a good touch with a smooth feeling was obtained. Example 3 To 0.4 g of concentrated benzalkonium chloride liquid (pharmacopoeia), 83 ml of pharmacological ethanol and macrogol 6000 (pharmacopoeia)
0.1 g was added, and water was further added to make the total volume 100 ml. Then, malic acid was added to adjust the pH to 6.0 to obtain a drug. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, a good touch with a smooth feeling was obtained. Example 4 To 0.4 g of concentrated benzalkonium chloride solution (pharmacopoeia), 83 ml of pharmacological ethanol, macrogol 6000 (pharmacopoeia)
0.1 g and 0.02 g of glycyrrhetinic acid were added, and water was further added to make the total volume 100 ml. Then, malic acid was added to adjust the pH to 6.0 to obtain a drug. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use,
It has a good touch with a smooth feel and a moist feeling. Example 5 In 0.4 g of concentrated benzalkonium chloride solution (pharmacopoeia), 83 ml of pharmacological ethanol, macrogol 6000 (pharmacopoeia)
0.1 g and 0.05 g of N-cocoyl-L-arginine ethyl ester-DL-pyrrolidone carboxylate were added, and water was further added to make the total volume 100 ml. Then, the pH was adjusted to 6.0 by adding malic acid. To obtain the drug. 3 ml of this drug was placed on the palm and rubbed well over the entire finger.
After use, it had a smooth feel and a moist and good touch. Example 6 To 0.4 g of concentrated benzalkonium chloride solution (pharmacopoeia), 83 ml of pharmacopoeia, Macrogol 6000 (pharmacopoeia)
0.1 g and 0.2 g of N-cocoyl-L-arginine ethyl ester-DL-pyrrolidonecarboxylate are added,
Water was further added to make the total volume 100 ml, and then malic acid was added to adjust the pH to 6.0 to obtain a drug. 3m of this medicine
l was placed on the palm of the hand and rubbed well over the entire finger. After use, it had a smooth feel and a moist and good touch.

EXAMPLE 7 To 0.4 g of concentrated benzalkonium chloride solution (pharmacopoeia), 83 ml of pharmacological ethanol and 0.1 g of 2-hydroxyethyl stearate (coagulation point: 53 ° C.) were added, and water was further added. After adjusting the total volume to 100 ml, malic acid was added to adjust the pH to 6.0 to obtain a drug. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, it had a smooth feel and a moist and good touch. Example 8 To 0.4 g of concentrated benzalkonium chloride solution (pharmacopoeia), 83 ml of pharmacological ethanol, macrogol 6000 (pharmacopoeia)
0.1 g and 0.05 g of cetylpyridinium chloride are added,
Water was further added to make the total volume 100 ml, and then malic acid was added to adjust the pH to 6.0 to obtain a drug. 3m of this medicine
l was placed on the palm of the hand and rubbed well over the entire finger. After use, it had a smooth feel and a moist and good touch. Example 9 To 0.4 g of concentrated benzalkonium chloride liquid (pharmacopoeia), 83 ml of pharmacological ethanol and macrogol 4000 (pharmacopoeia)
(Polyethylene glycol, molecular weight 3,200, freezing point 55 ° C) 0.05 g and Macrogol 6000 (Europe)
After adding 0.05 g and further adding water to make the total volume 100 ml, the pH was adjusted to 6.0 by adding malic acid to obtain a drug. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, it had a smooth feel and a moist and good touch. Example 10 In 1 ml of chlorhexidine gluconate solution (pharmacopoeia), 83 ml of pharmacopoeia ethanol and Macrogol 6000 (pharmacopoeia) 0.1
g was added, and water was further added to make the total volume 100 ml, thereby preparing a drug. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, a good touch with a smooth feeling was obtained. Example 11 1 ml of chlorhexidine gluconate solution (pharmacopoeia), 83 ml of pharmacopoeia ethanol, macrogol 6000 (pharmacopoeia) 0.1
g and ethylenediaminetetraacetic acid disodium salt 0.01
Add 3 g, add water to make the total volume 100 ml,
The drug was prepared. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, a good touch with a smooth feeling was obtained. Example 12 1 ml of chlorhexidine gluconate solution (pharmacopoeia), 83 ml of pharmacological ethanol and macrogol 6000 (pharmacopoeia) 0.1
g was added, and water was further added to make the total volume 100 ml. Then, malic acid was added to adjust the pH to 6.0 to obtain a drug. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, a good touch with a smooth feeling was obtained. Example 13 In 1 ml of chlorhexidine gluconate solution (pharmacopoeia), 83 ml of pharmacopoeia, macrogol 6000 (pharmacopoeia) 0.1
g and glycyrrhetinic acid (0.02 g), and water to make a total volume of 100 ml.
Was adjusted to 6.0 to give the drug. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, it had a smooth feel and a moist and good touch. Example 14 To 1 ml of chlorhexidine gluconate solution (pharmacopoeia), 83 ml of pharmacological ethanol and macrogol 6000 (pharmacopoeia) 0.1
g and N-cocoyl-L-arginine ethyl ester-
After adding 0.05 g of DL-pyrrolidone carboxylate and further adding water to make the total volume 100 ml, malic acid was added to adjust the pH to 6.0 to obtain a drug. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use, it had a smooth feel and a moist and good touch. Example 15 To 1 ml of chlorhexidine gluconate solution (pharmacopoeia), 83 ml of pharmacological ethanol, macrogol 6000 (pharmacopoeia) 0.1
g and N-cocoyl-L-arginine ethyl ester-
0.2 g of DL-pyrrolidone carboxylate was added, and water was further added to make the total amount 100 ml. Then, malic acid was added to adjust the pH to 6.0 to obtain a drug. 3 ml of this drug was placed on the palm and rubbed well over the entire finger. After use,
It has a good touch with a smooth feel and a moist feeling.

Example 16 (Performance Evaluation Test) A performance evaluation test was performed on the drug containing benzalkonium chloride prepared in Comparative Example 1 and Examples 1 to 9.
As test bacteria, Pseudomonas aerug
inosa IFO 3080 (abbreviation P. aerugin)
osa), Escherichia coli IFO 3
301 (abbreviation E. coli), Staphylococ
cus aureus ATCC 6538P (abbreviated as S.A.
aureus), Klebsiellapneumon
iae ATCC 4352 (K. pneumoni)
ae) and Serratia marcescens clinical isolates (abbreviated as S. marcescens) were used. One platinum loop of the test bacterium was inoculated into 8 ml of SCD medium [Digo, Nippon Pharmaceutical Co., Ltd.], cultured at 37 ° C. for 18 hours, and 1 ml of the culture was diluted 10-fold with SCD medium.
Further, 2 ml of this diluted solution was inoculated into 100 ml of SCD medium, and aeruginosa was cultured at 37 ° C. for 4 hours, and the other four types of bacteria were cultured at 37 ° C. for 2 hours to obtain test bacterial solutions. The test bacterial solution contains 10 ⁷ to 10 ⁸ viable cells per ml. A two-fold dilution series of the benzalkonium chloride-containing drug prepared in Comparative Example 1 and Examples 1 to 9 with sterile physiological saline was prepared, and 0.1 ml of the test bacterial solution was added to 10 ml of each drug diluent. And mixed. After contacting the bacterium with the drug diluent for 1 minute, about 3 μl of this contact solution was used as an inactivating agent [L
P diluent, Daigo, Nippon Pharmaceutical Co., Ltd.] and spread on SCD agar medium [Digo, Nippon Pharmaceutical Co., Ltd.]. Was determined. The minimum germicidal concentration of benzalkonium chloride is comparative example 1.
And all the drugs of Examples 1 to 9 aeru
250 μg / ml against E. ginosa; 16 μg / ml for S. coli. 16μ for Aureus
g / ml, K.I. 16 μg / pneumoniae
ml, S.M. 32 μg / ml for Marcescens. Example 17 (Performance evaluation test) A performance evaluation test was performed for the drug containing chlorhexidine gluconate prepared in Comparative Example 2 and Examples 10 to 15 in the same manner as in Example 16. The minimum bactericidal concentration of chlorhexidine gluconate was determined in Comparative Example 2 and Example 10.
P. 15 for all drugs. aeruginos
250 μg / ml for E. a. 16 against E. coli
μg / ml, S.P. 16 μg / ml for Aureus,
K. 16 μg / ml against S. pneumoniae;
32 μg / ml for Marcescens.
Tables 1 and 2 show the results of Example 16 and Example 17.

[0011]

[Table 1]

[0012]

[Table 2]

[0013]

[Table 3]

As can be seen in Tables 1 and 2, it contains benzalkonium chloride or chlorhexidine gluconate and is used as a macrogol 6000 or macrogol 6000.
The minimum germicidal concentration measured for the germicidal disinfectant composition of the example to which malic acid was added was the minimum germicidal concentration measured for the germicidal disinfectant composition of the comparative example consisting of an aqueous ethanol solution of benzalkonium chloride or chlorhexidine gluconate. It is completely consistent, and it can be seen that the addition of Macrogol 6000 or Macrogol 6000 and malic acid has no adverse effect on the medicinal effect. Example 18 Ten kinds of disinfectant compositions containing benzalkonium chloride were prepared in the same manner as in Comparative Example 1 and Examples 1 to 9 except that isopropanol was used instead of ethanol. Then, it was rubbed with a finger to examine the feeling of use, and a performance evaluation test was performed. Both the feeling of use and the results of the performance evaluation test completely coincided with the results of Comparative Example 1 and Examples 1 to 9 using ethanol in the local state. Example 19 Seven kinds of germicidal disinfectant compositions containing chlorhexidine gluconate were prepared in the same manner as in Comparative Example 2 and Examples 10 to 15 except that isopropanol was used instead of ethanol. A feeling of use was examined by rubbing the finger, and a performance evaluation test was performed. Both the feeling of use and the results of the performance evaluation test were completely consistent with the results of Comparative Example 2 and Examples 10 to 15 using ethanol in the local state. Example 20 The same concentrated benzalkonium chloride solution 50 (Europe), ethanol, Macrogol 6000 (Europe), N-cocoyl-L-arginine ethyl ester as in Example 5
A drug containing DL-pyrrolidone carboxylate and water, adjusted to pH 6.0 by adding malic acid, was used at an age of 18
Tactile sensation when 3 ml of the drug was rubbed into fingers was investigated using 25 males and 25 females aged 52 to 52 years as subjects. 37 with dry feeling, 8 with no feeling, 5 with unknown, 20 with moist feeling after drying, 18 with no feeling, etc. There were 12 people who were unknown, 7 people who had a feeling of dryness after drying, 42 people who did not, and 1 person who was unknown. Table 3 shows the results for other evaluation items.

[0015]

[Table 4]

As can be seen from Table 3, many subjects rated "good" for the smooth and moist feeling, which is a good tactile sensation, and evaluated the slimy, nichatsuki, and sticky feelings of unpleasant tactile sensations. Many subjects are "none"
It is evaluated. In addition, itching, rash, pain, and rough skin, which are skin disorders, did not occur at all. From these results, it can be seen that the germicidal disinfectant composition of the present invention has no skin irritation, can be used safely, and has a good feel after use.

[0017]

The germicidal disinfectant composition of the present invention can be used as a polyalkylene glycol having a freezing point of 35 ° C. or more or a freezing point of 35 ° C. with respect to a lower alcohol solution of a quaternary ammonium salt-based disinfectant or a biguanide-based disinfectant. By blending the above alkylene glycol derivative in an amount of 0.01 to 2% by weight, an unpleasant touch such as stickiness when using the drug can be obtained, and an excellent touch such as a smooth feeling and a moist feeling can be provided after use. Further, by adjusting the pH to 4 to 8 by adding a carboxylic acid or a carboxylate, irritation to the skin can be reduced.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A01N 47/44 A01N 47/44 (72) Inventor Kimihiro Makino 4-23-1, Bunkyo, Fukui-shi, Fukui Sun Hua Kagaku Co., Ltd. F-term (reference) 4H011 AA01 BA01 BA03 BB04 BB11 BC03 DA13

Claims (2)

[Claims] 1. A polyalkylene glycol having a freezing point of 35 ° C. or more or a derivative of an alkylene glycol having a freezing point of 35 ° C. or more is added to a lower alcohol solution of a quaternary ammonium salt-based disinfectant or a biguanide-based disinfectant. A disinfectant / disinfectant composition characterized by containing 0.01 to 2% by weight. 2. The disinfectant composition according to claim 1, wherein the pH is adjusted to 4 to 8 with a carboxylic acid or a carboxylic acid salt.