WO2008065734A1

WO2008065734A1 - Aqueous composition

Info

Publication number: WO2008065734A1
Application number: PCT/JP2007/001108
Authority: WO
Inventors: Yoshiro Tanaka; Tadahiko Mizuno
Original assignee: Oct Incorporated
Priority date: 2006-11-27
Filing date: 2007-10-12
Publication date: 2008-06-05
Also published as: JPWO2008065734A1

Abstract

In order to obtain a skin lotion which has high skin safety and less stickiness, gives a moist feeling, and has a high moisturizing effect, and further has a bactericidal effect, and drinking water which easily penetrates into the body at a low cost and high productivity, an aqueous composition characterized by comprising an aqueous solution containing at least either one of deuterium components, D2O and D2SO4, at 0.01 to 1.0% by volume is used.

Description

Specification

Water composition

Technical field

[0001] The present invention is suitable for a lotion having high skin safety, less stickiness, moist feeling, high moisturizing effect, and also having a bactericidal effect, and drinking water that is efficiently absorbed by the body. The present invention relates to a water composition that can be used.

Background art

[0002] Conventionally, lotion has been used as a skin cleanser and a skin beautifying effect. For example, lotion contains a lot of moisturizers, and these moisturizers can moisturize the skin by retaining moisture, but in some cases they can also give a feeling of stickiness. is there

[0003] On the other hand, in Patent Document 1, for example, a hydrophilic surfactant (nonionic surfactant), 16-6, which is intended to realize a skin lotion with less stickiness and a high moisturizing effect. A lotion containing liquid oil and humectant with a solubility parameter of 19 has been proposed.

[0004] Further, for example, in Patent Document 2, there is a substitution group with the intention of providing a skin lotion with high skin safety, less stickiness and a moisturizing effect, and a high moisturizing effect. A cosmetic comprising an acyl compound having an acyl group of 1 to 40 carbon atoms, which is a straight chain, branched chain, cyclic chain or aromatic hydrocarbon chain, a moisturizing component, an alcohol, and an oily component Water has been proposed.

Patent Document 1: Japanese Patent Laid-Open No. 9_3 0 1 8 1 8

Patent Document 2: Japanese Patent Laid-Open No. 2 0 06 _5 6 8 20

Disclosure of the invention

Problems to be solved by the invention

[0005] However, even with the lotions proposed in Patent Documents 1 and 2, there is still room for improvement with respect to the problem of stickiness. In addition, the lotion proposed in Patent Document 2 has many components. There were also problems of low cost and poor productivity.

[0006] In addition, most conventional lotions are manufactured in consideration of skin safety, low stickiness, moist feeling and moisturizing effect, and exist in skin such as human hands. No attention has been paid to the bactericidal effect on the various bacteria obtained.

Therefore, in view of the conventional problems as described above, an object of the present invention is a skin lotion that has high skin safety, less stickiness, moisturizing effect, high moisturizing effect, and bactericidal effect. A water composition that can be used preferably, is harmless and easily absorbed by the body, and can be suitably used for drinking water suitable for promoting health and taking medicine, etc. at low cost and high productivity. The purpose is to obtain.

Means for solving the problem

[0008] In order to solve the above problem, the present invention provides an aqueous composition comprising an aqueous solution containing a deuterium component (particularly at least one of D ₂ 0 and D ₂ S 0 ₄ ). provide. With such a configuration, the size of water molecules in the aqueous solution can be reduced, and thus, when the water composition is used as a skin lotion, the effect of being easily penetrated by the skin is expected. The In addition, when the above water composition is used as potable water, an effect of being easily absorbed by the body is expected.

[0009] It is preferable that the aqueous solution contains 0.01 to 1.0% by volume of the deuterium component. For example, when the aqueous solution is used as a lotion or the like, it is preferable that the deuterium component is contained in an amount of 0.04 to 1.0% by volume. Among these, the lower limit value of the deuterium component is preferably 0.05% by volume. The upper limit of the deuterium component, 0. Is preferably from 2% by volume, 0. 1 5 vol ^_0/0, the Raniwa 0. Is preferably 1% by volume.

[0010] In addition, when the aqueous solution is used as drinking water, it is sufficient that water molecules at the closest distance are contained, so that the deuterium component should be contained in an amount of not less than 0.01% by volume. . In particular, the content of the deuterium component may be 0.15 to 0.04% by volume, and may be about 0.02% by volume. of course The deuterium content of the lotion may be the same.

[001 1] If the content of the deuterium component is as described above, the effect of being easily penetrated by the skin as described above and the effect of being easily absorbed by the body are expected more reliably.

[0012] The pH of the aqueous solution may be near neutral, but is preferably 1.5 to 5.0. In particular, when the pH force is 2.5 or less, the water composition of the present invention exhibits a good sterilizing effect. Moreover, if the pH is 3.5 or more, the metabolic effect of the skin and the recovery effect of the skin are improved.

[0013] The water composition of the present invention can be suitably used as a lotion or drinking water. The lotion may be for humans or for animals. In addition, drinking water may be used when taking medicines. Furthermore, the water composition of the present invention can be used as various cleaning solutions.

The invention's effect

[0014] According to the present invention, only an inexpensive and safe deuterium component and water are used as raw materials, skin safety is high, there is little stickiness, moist feeling, high moisturizing effect, and bactericidal effect. A water composition that can be used as a lotion, or a potable water that is harmless to the body and is suitable for promoting health and taking medicine, can be obtained more reliably at low cost and with high productivity.

Brief Description of Drawings

[0015] [Fig. 1] Diffraction angle of 20 ° to 40 ° for water added with heavy water (water composition comprising an aqueous solution containing the deuterium component of the present invention) and normal water (tap water) 3 is a graph showing the results of measurement in the range of 20;

[FIG. 2] A graph showing the diffraction angle 20 (°) shown in FIG. 1 converted into a distance using the equation of si η, the distance on the horizontal axis, and the diffraction intensity (arbitrary) on the vertical axis. It is.

[Fig.3] Diffraction intensity at closest distance of 2.97 angstrom between oxygen molecules

Is a graph shown as a function of heavy water concentration.

FIG. 4 is a graph showing the relationship between the survival rate of E. coli and ρ. FIG. 5 is a graph showing the relationship between the survival rate of S. aureus and pH.

BEST MODE FOR CARRYING OUT THE INVENTION

[0016] In water and aqueous solutions, water molecules are constantly moving and their positions are changing. It is known that large and small clusters (cluster one) are formed because there is an interaction due to hydrogen bonds between water molecules, and a weak binding force works between adjacent water molecules. This can be confirmed by X-ray diffraction, neutron diffraction, Raman spectrum, mass spectrometry, etc. in recent years.

[0017] The present inventors measured the structure and state of water molecules by adding X-ray diffraction when a deuterium component was added to water, and as a result of intensive experiments on the effects, the results were new and remarkable. As a result, the present invention has been completed. More specifically, X-ray diffraction measurement was performed under the following conditions using Geigerflex (trade name) manufactured by Rigaku.

[0018] ■ Tube: C u— K

■ Energy: 30 K e V

• Current: 20mA

■ Measurement part: Measurement part obtained by forming an opening (18mmXl 8mm) in a glass holder (35mmX 5 OmmX 1.5mm) and forming a 5m-thick fluororesin film on the inner surface

■ Temperature: 20 ° C (Constant temperature room)

[0019] The diffraction angle was analyzed by rotating the goniometer at an angular velocity of 1 ° in, and all the X-ray data was assigned to the recording paper. The pure water used for the measurement was stored so as not to contaminate. In addition, 100% pure heavy water (D ₂ 0), which is a deuterium component, was used. Pure water contains 0.015% by volume of heavy water as inevitable heavy water.

[0020] Fig. 1 shows a diffraction angle of 20 ° to 40 ° for water added with heavy water (water composition comprising an aqueous solution containing the deuterium component of the present invention) and normal water (tap water) 20 The vertical axis shows the diffraction intensity (arbitrary), and the horizontal axis shows the diffraction angle 20 (°). Note that the heavy water concentration of the sample The following values were adjusted.

[0021] O: 0.0 1 5% by volume (pure water) (a)

▲: 0.025% by volume (b)

○: 0.1% by volume (c)

▽: 0.2% by volume (d)

♦: 1.0 vol% (e)

□: 0.05% by volume (f)

X: Fizzolem only

[0022] The intensity shown in FIG. 1 indicates the average distance between oxygen atoms in the water molecule averaged over time. This high strength means that there is a high probability that the oxygen intermolecular distance will approach at each distance. From Fig. 1, it can be seen that the diffraction intensity increased by a factor of 1.6, except for 0.02 5% by volume (▲) and film only (X). Whether it is heavy water or light water, the contribution of oxygen molecules, not hydrogen atoms or deuterium atoms, is almost the contribution to X-ray reflection. Therefore, it can be said that almost all of the diffraction intensities are caused by oxygen atoms.

Next, the diffraction angle 20 (°) shown in FIG. 1 is converted into a distance using the equation of si η 0 / λ, the distance is shown on the horizontal axis, and the diffraction intensity (arbitrary) is shown on the vertical axis. Figure 2 shows a graph showing the above. The above distance indicates the distance between oxygen atoms between water molecules. From Fig. 2, it can be seen that in the water with heavy water added, the diffraction intensity increases from the vicinity of 2.8 angstroms to 3.3 angstroms, which corresponds to the distance when water molecules are closest. , Except 0.025% by volume of the sample. From this result, it is clear that the average distance between water molecules can be affected by adding a little heavy water to water.

[0024] FIG. 3 is a graph showing the diffraction intensity at a closest distance of 2.97 angstroms between oxygen atoms as a function of the concentration of heavy water. The vertical axis shows the diffraction intensity (arbitrary), and the horizontal axis shows the heavy water concentration (volume%).

[0025] From Fig. 3, the diffraction intensity is 0.025% by volume (b in Fig. 3). Although it is reduced by about 15% compared to the case of addition (a in Fig. 3), it increases with further addition of heavy water, and is about 0.08% by volume (ie, the concentration of heavy water about 5 times that of nature). ), And is about 2.5 times that of the case of no addition (a in Fig. 3). From the above, the present inventors have found the following points.

[0026] That is, the structure of water (water molecules) after addition of heavy water can be traced by X-ray diffraction. When heavy water is added to water, the distance between oxygen atoms changes, and the state of aggregation of water molecules changes. More specifically, as can be seen from FIG. 3, when the concentration of heavy water is 0.04 to 1.0% by volume, the distance between oxygen atoms between water molecules is small. This indicates that it is due to the structural change of the whole water molecule.

[0027] Since water molecules are becoming smaller in this way, when a water composition composed of an aqueous solution having a heavy water concentration of 0.04 to 1.0% by volume is used as a lotion, the water molecules are more reliably It can be seen that it penetrates the skin and provides high skin safety, excellent moistness with little stickiness, and high moisturizing effect.

Further, as can be seen from FIG. 3, from the viewpoint that the effect of being easily penetrated by the skin as described above and the effect of being easily absorbed by the body is expected more reliably, the lower limit of the heavy water concentration The value is preferably 0.05% by volume. The upper limit value of the heavy water concentration is preferably 0.2% by volume, 0.15% by volume, and more preferably 0.1% by volume.

[0029] In addition, when a water composition composed of an aqueous solution having a heavy water concentration of 0.04 to 1.0% by volume is used as drinking water, water molecules can penetrate into the body more reliably and have a high water supply effect. It can be seen that However, as described above, when the aqueous solution is used as drinking water or the like, the deuterium component is contained in an amount of 0.01% by volume or more because it is only necessary to contain even a few water molecules at the closest distance. Just do it.

[0030] Further, the present inventors investigated the relationship between the pH and the bactericidal effect using the above-described sample. More specifically, the following experiment was conducted.

[0031] 1. Relationship between E. coli viability and pH

E. coli (E.) With various pH (adjusted using sulfuric acid or bisulfate) shown in Figure 4. co I i) was then treated, and then E. coli was cultured in a petri dish medium under a constant amount and under constant conditions, and the number of colonies was counted after 10 minutes and 30 minutes, respectively. Figure 4 shows the results. From FIG. 4, it can be seen that from the viewpoint of the bactericidal effect, it is preferably acidic, and in particular, the pH is preferably 2.5 or less.

[0032] 2. Relationship between S. aureus viability and pH

S. aureus is treated with various pHs (adjusted with sulfuric acid or bisulfate) as shown in Fig. 5, and then a certain amount of S. aureus is treated in a petri dish medium under certain conditions. And the number of colonies was counted after 10 minutes and 30 minutes. The results are shown in Fig. 5. From FIG. 5, it can be seen that from the viewpoint of the bactericidal effect, it is acidic, and in particular, the pH is preferably 2.5 or less.

[0033] Further, according to the knowledge of the present inventors, it has been confirmed that if the pH of the aqueous solution is 3.5 or more, the metabolic effect of the skin and the recovery effect of the skin are improved. In this regard, the present inventors further speculate as follows. That is, when the water composition of the present invention is applied to skin lotion and applied to or sprayed on the skin, hydrogen ions derived from the deuterium component are in an unstable state, so that the hydrogen ions are in the skin. Since it can immediately contribute to the chemical reaction with the stratum corneum, it is considered that the above-mentioned effects can be obtained.

[0034] On the other hand, for example, when sulfuric acid is applied or sprayed onto the skin, a part (for example,

(About 1%) of the sulfuric acid component remains on the surface of the skin, and if there is little moisture, the concentration of the sulfuric acid component on the skin will rise relatively, causing the skin to become rough.

Based on the above findings, the present inventors have completed the present invention. That is, the water composition of the present invention is composed of an aqueous solution containing a deuterium component, and the aqueous solution is basically composed of a deuterium component and water.

[0036] The water is preferably water of higher purity, but various waters such as natural water such as mineral spring water, tap water, distilled water, and ion exchange water may be used. it can.

[0037] The composition of tap water varies depending on the area provided, but tap water available in any area can be used. Among them, it contains a lot of minerals When water that is rarely used is used, there is a merit that it is easily absorbed into the skin and body together with the small water molecules contained in the water composition of the present invention.

[0038] As the deuterium component, heavy water in which a part of hydrogen atoms is replaced by deuterium atoms.

(D ₂ 0), diuterium sulfate (D ₂ S 0 ₄ ) or deuterium sulfide (D ₂ S) in which a part of hydrogen atoms are substituted with deuterium atoms are preferred. Among these, at least one of D ₂ 0 and D ₂ S 0 ₄ is preferable from the viewpoint of being inexpensive, easily available, and excellent in skin safety.

[0039] Further, the skin lotion of the present invention may contain various optional components as long as the effects of the present invention are not impaired. For example, optional acid components that the acidic aqueous solution may contain include, for example, inorganic acids such as sulfuric acid, hydrochloric acid and nitric acid, and succinic acid, glycine, cinnamate, succinic acid, salicylic acid, formic acid, glutamic acid, ascorbic acid, Examples include organic acids such as oxalic acid, tartaric acid, lactic acid and acetic acid. Two or more of these acid components may be contained in the acidic aqueous solution, or an inorganic acid and an organic acid may be contained in combination. It may also contain pigments and dyes.

Industrial applicability

[0040] The water composition of the present invention contains small water molecules, has high skin safety, low stickiness, moist feeling, high moisturizing effect, further sterilizing effect, low cost and It can be obtained with high productivity. Further, the water composition of the present invention can be applied to drinking water and various cleaning solutions in addition to cosmetic water.

Claims

The scope of the claims

[1] A water composition comprising an aqueous solution containing 0.01 to 1.0% by volume of a deuterium component.

[2] the water composition of claim 1 wherein the deuterated component, wherein at least one of D ₂ O and D ₂ SO _4.

[3] The water composition according to claim 1 or 2, wherein the pH is 1.5 to 5.0.

[4] A lotion comprising the water composition according to any one of claims 1 to 3.

[5] The lotion according to claim 4, comprising 0.04 to 1.0% by volume of the deuterium component.

[6] Drinking water comprising the water composition according to any one of claims 1 to 3.

7. The drinking water according to claim 6, wherein the deuterium component is contained in an amount of 0.01 to 0.04% by volume.