JPH10194948A - Skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin lotion containing propolis extract and horse oil and capable of further improving the skin conditions such as chapped skin. SOLUTION: This skin lotion having the form of cream, milky lotion, face lotion, face oil, pack, etc., can be produced by compounding (A) 0.01-10wt.% of prpolis extract obtained by extracting a resinous substance collected from the hive of honeybee (Apis mellifara L., Apis indica RODOSZKOWSKI) of the family Apidae with an organic solvent (e.g. ethanol) and composed mainly of flavonoids, (B) 0.01-10wt.% of horse oil (or its partial hydrogenate) which is a fat oil obtained from the base of mane and tail or subcutaneous fat of hors [Equus caballus (Equoidae)] and, an necessary, (C) oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols, esters, surfactant, ultraviolet absorbing and scattering agent, humectant, thickener, nutrient, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin, specifically a cream, emulsion, lotion,
The present invention relates to a skin external preparation such as a cosmetic oil or a pack.

[0002]

2. Description of the Related Art Numerous physiological actions have been found in propolis extract, and cosmetics containing the propolis extract are expected to be effective in improving various skin conditions. Horse oil has also been conventionally applied to the skin. As described above, various skin external preparations have been proposed, but more satisfactory skin external preparations have been demanded in order to improve skin symptoms such as rough skin.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide an external preparation for skin which can improve skin conditions such as rough skin.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies in order to achieve the above object, and as a result, they have used propolis extract and horse oil in combination in a skin external preparation to use them alone. At times, it was found that an excellent synergistic effect was observed, a high moisturizing effect was exhibited on the skin, and symptoms such as rough skin could be improved, and the present invention was completed. Further, as a result, an external preparation for skin having both the physiological effects such as the bactericidal action and anti-inflammatory action of the propolis extract and the action effect of horse oil is obtained. Therefore, the present invention relates to an external preparation for skin characterized by containing a propolis extract and horse oil. In a preferred embodiment of the present invention, a partially hydrogenated horse oil is used as horse oil and an alcohol extract is used as propolis extract.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.
The external preparation for skin of the present invention can be provided in the form of cream, emulsion, lotion, cosmetic oil, pack, and the like. The propolis extract used in the present invention is an extract of an anodized substance (referred to as “propolis”) obtained from the nest of the honeybee (Apis mellifera L., Apis indica RODOSZKOWSKI) with an organic solvent. The main component is a flavonoid. Specifically, extracts with alcohols, especially ethanol, are well known and are typically used in the present invention. Propolis extract is generally available on the market, and such a commercial product can be used in the present invention. The horse oil used in the present invention is horse E
It is known as a fat oil obtained from the mane and tail base of quus caballus (Equoidae), or subcutaneous fat. Also, its partially hydrogenated products are known. In the present invention, these commercially available horse oils can be used.

[0006] The amount of the propolis extract in the external preparation for skin of the present invention is from 0.01 to the total weight of the external preparation for skin.
10% by weight is suitable, preferably 0.5-5% by weight. When the amount of the propolis extract is less than 0.01% by weight, the effect of improving skin symptoms is not sufficiently exhibited, and
If it exceeds 10% by weight, the stability of the preparation tends to decrease. The amount of horse oil in the skin external preparation of the present invention is suitably 0.01 to 10% by weight, preferably 0.1 to 8% by weight, based on the total weight of the skin external preparation. The amount of horse oil
If the amount is less than 0.01% by weight, the intended effect of the present invention is not exhibited, and if it exceeds 10% by weight, the stability of the preparation tends to decrease. The external preparation for skin of the present invention appropriately uses additives used for cosmetics and the like in a range that does not impair the effects of the above components, depending on the form such as cream, milky lotion, and lotion (to be in a somewhat suspension form). can do.
Such additives are, for example, fats and oils, waxes, hydrocarbons, fatty acids, higher alcohols, esters, surfactants, ultraviolet absorbing and scattering agents, humectants, thickeners, nutrients, and the like. . The specific examples are shown below.

Oils and fats: vegetable oils such as castor oil, olive oil, cacao oil, camellia oil, jojoba oil and avocado oil;
Animal fats and oils such as mink oil and egg yolk oil. Waxes: beeswax, beeswax, lanolin, carnauba wax, candelilla wax and the like. Hydrocarbons: liquid paraffin, liquid isoparaffin, squalane, microcrystalline wax, ceresin wax, paraffin wax, petrolatum, etc. Fatty acids: lauric acid, myristic acid, palmitic acid,
Stearic acid, oleic acid, isostearic acid, behenic acid, etc. Higher alcohols: cetanol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol, etc. Esters: isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, octyldodecyl oleate, cholesterol ester and the like.

Surfactants: Nonionic surfactants such as lipophilic or self-emulsifying glycerin monostearate, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene (POE) sorbitan fatty acid ester, POE hydrogenated castor oil and the like. , Fatty acid potassium salt, fatty acid sodium salt, fatty acid triethanolamine salt, P
Anionic surfactants such as sodium OEalkyl ether sulfate. Cationic surfactants such as alkyltrimethylammonium chloride. Amphoteric surfactants such as lecithin and alkylaminoethylglycine hydrochloride solution. Ultraviolet absorbing / scattering agents: 2-hydroxy-4-methoxybenzophenone, octyldimethyl paraaminobenzoate, ethylhexyl paramethoxycinnamate, titanium oxide, zinc oxide, kaolin, talc and the like. Humectants: polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol, polyglycerin, and polyethylene glycol. NMF components such as amino acids and sodium pyrrolidonecarboxylate. Water-soluble polymer substances such as hyaluronic acid, collagen, mucopolysaccharides, and chondroitin sulfate.

Preservatives: benzoate, salicylate, sorbate, dehydroacetate, p-hydroxybenzoate, triclosan, triclocarban, benzalkonium chloride, benzethonium chloride, hinokitiol, phenoxyethanol and the like. Thickeners: sodium alginate, xanthan gum, hydroxyethyl cellulose, carrageenan, carboxyvinyl polymer, cationized cellulose, polyvinyl alcohol, metal soap and the like. Nutrition: vitamin A, vitamin B group, vitamin C, vitamin D, vitamin E, vitamin F, vitamin K, vitamin P, and the like. These additives are used in an amount which is usually incorporated into an emulsified composition such as a cream or an emulsion.

The external preparation for skin of the present invention can be prepared according to a conventional method according to the form. For example, it can be prepared by general methods such as emulsification, solubilization, dispersion, and kneading. If the intended skin external preparation is an emulsion,
It can be prepared by a phase inversion temperature emulsification method, a D-phase emulsification method, an amino acid gel emulsification method, a liquid crystal emulsification method, or the like. It is preferable that the propolis extract and horse oil are prepared by mixing as an oil phase component. In addition, preparation conditions such as stirring and heating temperature can be appropriately selected according to the form of the external preparation for skin and other components.

[0011]

The external preparation for skin of the present invention exerts a high moisturizing effect on the skin and shows an excellent improvement effect on symptoms such as rough skin.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples.

Examples 1 to 3 and Comparative Examples 1 to 4 Various creams were prepared according to the following composition and composition (unit: parts by weight). In addition,
In the composition, the blending amounts of the propolis extract and the partially hydrogenated horse oil are as shown in Table 1. 1. Diglyceryl sesquiisostearate 4.0 2. Glyceryl monooleate 6.0 3. Metal soap 3.8 4. Propolis extract See Table 1 5. Partially hydrogenated horse oil See Table 1 6. Glycerin 10.0 7 Paraben 0.3 8. Liquid paraffin 15.0 9. Salami beeswax 1.0 10. Sodium glutamate 2.4 11. Purified water qs 100.0 Preparation procedure Above 1, 3, 5, 8, 9 at 80 ° C Mixed in this,
A solution obtained by heating and dissolving 10 was added to some of 2 and 11. Next, a solution obtained by uniformly dissolving the rest of 6, 7, and 11 was heated to 80 ° C., and this was gradually added to the above mixture to emulsify and cooled to room temperature.

[0013]

[Table 1] ─────────────────────────────── Propolis extract partially hydrogenated horse oil ────────実 施 Example 1 3.0 3.0 〃 2 1.5 1.5 〃 3 1.0 1.0 −− −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Comparative Example 1 −3.0 〃 2 3.0 − 〃3 −6.0 〃4 6.0-───────────────────────────────

Comparative test of effect of improving skin condition The creams prepared as described above were used as test samples, and each sample was evaluated by 15 panelists (male and female, 25 to 35 years old). An artificial rough skin was created with a sodium lauryl sulfate solution in a range of 3 × 3 cm inside the upper arm of each paneler.
Test sample is placed on the site twice a day for two weeks (morning and evening)
Applied. The improvement effect of the rough skin is measured by measuring the water content of the stratum corneum reflecting the rough skin condition using a SKICON 200 (manufactured by IBS), and the degree of improvement [(2
(Measured value after week / initial value) × 100] was calculated, and the average value was calculated. The higher this value, the higher the degree of improvement in moisturizing the skin. Further, the degree of improvement of the desquamation in the cream-coated part was visually observed, and the desquamation amount was classified into three stages as follows, and the number of panelists was shown. The results are shown in Table 2 below.

[0015]

[Table 2] ──────────────────────────────────── Test sample At the start of the stratum corneum water content test after two of desquamation weeks of desquamation degree of improvement + ± - + ± - ────────────────────────────────── ── Example 1 172 12 3 0 0 1 14 〃 2 153 12 3 0 0 2 13 ３ 3 137 11 4 0 1 2 12 −−−−−−−−−−−−−−−−−−−−−−− −−−−−−−−−−−−−−−−− Comparative Example 1 118 12 3 0 6 6 3 〃 2 97 14 1 0 10 4 1 ３ 3 126 11 4 0 2 8 5 ４ 4 109 14 1 0 8 6 1 ────────────────────────────────────

[0016]

Example 4 Preparation of Cream A cream was prepared by the following composition and formulation (unit: parts by weight). 1. Glyceryl monooleate 6.0 2. Diglyceryl triisostearate 4.0 3. Magnesium stearate 1.2 4. Aluminum stearate 0.6 5. Zinc laurate 2.0 6. Beeswax 2.0 7 Paraffin wax 3.2 8. Liquid paraffin 15.0 9. Propolis extract 3.0 10. Partially hydrogenated horse oil 8.0 11. Paraben 0.2 12. Glycerin 10.0 13. Aloe extract 0.1 14 Jojoba oil 0.1 15. Sodium glutamate 2.4 16. Purified water Total amount 100.0 Preparation procedure: The above 2 to 10 and 14 are uniformly dissolved at 80 ° C.
To this is added 15 dissolved in parts of 1 and 16. to this
A mixture obtained by uniformly heating and mixing 11, 12, and 16 was gradually added to emulsify, and further 13, 13 was added and cooled to 30 ° C.

[0017]

Example 5 Preparation of Milk Lotion A milk lotion was prepared according to the following composition and composition (unit: parts by weight). 1. Polyglyceryl monolaurate 2.8 2. Diglyceryl monooleate 0.7 3. Lipophilic glyceryl monostearate 0.2 4. Tri (caprylic / capric acid) glycerol 8.0 5. Squalane 2.06 Jojoba oil 0.5 7. Partially hydrogenated horse oil 0.5 8. Paraben 0.3 9. Propolis extract 3.0 10. 1,3-butylene glycol 6.0 11. Carboxyvinyl polymer 0.3 12. Sodium hydroxide Appropriate amount 13. Purified water Total amount of residual 100.0 Preparation procedure: The above 1 to 10 are uniformly heated and dissolved at 80 ° C, and 11 is dissolved in 13 and heated to 80 ° C gradually. And emulsify. Next, the mixture was cooled to 65 ° C., a solution of 12 dissolved in a part of 13 was added, and the mixture was further cooled to 30 ° C.

[0018]

Example 6 Preparation of lotion A lotion was prepared according to the following composition and formulation (unit: parts by weight). 1. Polyoxyethylene hydrogenated castor oil 1.0 2. Partially hydrogenated horse oil 0.1 3. Paraben 0.3 4. 1,3-butylene glycol 6.0 5. Propolis extract 3.0 6. Ethanol 10. 0 7. Citric acid appropriate amount 8. Sodium citrate appropriate amount 9. Purified water Total remaining amount 100.0 Preparation procedure: The above 1 to 4 were uniformly mixed and dissolved, and 5 dispersed in 6 was added. Further, a solution in which 7 and 8 were uniformly dissolved in 9 was added.

[0019]

Example 7 Preparation of Cosmetic Oil A cosmetic oil was prepared according to the following composition and composition (unit: parts by weight). 1. Sorbitan monoisostearate 3.0 2. Octyldodecanol 8.0 3. Partially hydrogenated horse oil 2.0 4. Propolis extract 0.5 5. Liquid paraffin Remaining 100.0 Preparation procedure: 1 to 4 Was dispersed, and 2, 3 and 5 were sequentially added thereto and uniformly mixed.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Nobuyuki Doi 3-666-71 Hibarigaoka, Zama City, Kanagawa Prefecture

Claims (2)

[Claims] 1. An external preparation for skin comprising a propolis extract and horse oil. 2. The external preparation for skin according to claim 1, wherein the horse oil is a partially hydrogenated horse oil.