JP2017178855A - External composition for concealing wrinkle and/or pore - Google Patents
External composition for concealing wrinkle and/or pore Download PDFInfo
- Publication number
- JP2017178855A JP2017178855A JP2016069071A JP2016069071A JP2017178855A JP 2017178855 A JP2017178855 A JP 2017178855A JP 2016069071 A JP2016069071 A JP 2016069071A JP 2016069071 A JP2016069071 A JP 2016069071A JP 2017178855 A JP2017178855 A JP 2017178855A
- Authority
- JP
- Japan
- Prior art keywords
- powder
- composition
- wrinkles
- external
- pores
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、粉体の分散安定性が向上している、シワ及び/又は毛穴の隠蔽用の外用組成物に関する。 The present invention relates to an external composition for concealing wrinkles and / or pores, which has improved dispersion stability of powder.
近年、美肌に対する関心の高まりを受け、自然な若々しい印象を与えるためのエイジングケアに注目が集まっている。とりわけ、シワや開いた毛穴は、肌印象を悪化させる大きな要因になっており、シワや毛穴に対する対処は美容上の大きな関心事になっている。 In recent years, attention has been focused on aging care for giving a natural and youthful impression in response to increasing interest in beautiful skin. In particular, wrinkles and open pores are a major factor that makes skin impression worse, and dealing with wrinkles and pores has become a major cosmetic concern.
従来、シワや毛穴への対処策として、二酸化ケイ素や酸化チタン等の粉体が含む外用組成物を使用して、シワや毛穴を隠蔽して目立たなくする美容法が知られている。しかしながら、粉体は分散安定性が悪いため、粉体を含む外用組成物は、製剤化の過程でダマが発生したり、経時的に粉体の沈降や凝集が生じたりするという問題点がある。そのため、シワや毛穴の隠蔽に使用される外用組成物は、粉体の分散安定性を向上させる製剤化技術が求められている。 Conventionally, as a countermeasure against wrinkles and pores, a cosmetic method is known in which a composition for external use contained in powders such as silicon dioxide and titanium oxide is used to hide wrinkles and pores and make them inconspicuous. However, since the powder has poor dispersion stability, the composition for external use containing the powder has a problem in that it causes lumps during the preparation process and the powder settles or aggregates over time. . Therefore, an external composition used for concealing wrinkles and pores is required to have a formulation technique for improving the dispersion stability of the powder.
これまでに、外用組成物中で粉体の分散安定性を高める製剤化技術について種々提案されている。例えば、特許文献1には、水中油型乳化組成物において、油層に、疎水化処理粉体、50質量%以上のシリコーン油、並びにポリオキシアルキレン変性ポリシロキサン及び/又はイソステアリン酸を含有させることによって、粉体の分散安定性を向上させ得ることが報告されている。また、特許文献2には、水中油型乳化組成物において、油層に、特定量のシリコーン油、HLB5以下の両親媒性物質、特定のアクリルシリコーンを含有させることによって、粉体に良好な分散安定性を備えさせ得ることが報告されている。特許文献3には、アクリロイルジメチルタウリン塩とアクリル酸ヒドロキシエチルとの共重合体を含む水相と、粉体を含む油相を含む水中油型乳化組成物は、粉体の凝集や沈降を改善できることが報告されている。特許文献4には、化粧料において、粉体と特定の両末端シリコーン変性グリセリンとを共存させることにより、粉体の分散安定性が向上することが報告されている。 So far, various preparation techniques for improving the dispersion stability of powders in external compositions have been proposed. For example, Patent Document 1 discloses that in an oil-in-water emulsion composition, the oil layer contains a hydrophobized powder, 50% by mass or more of silicone oil, and polyoxyalkylene-modified polysiloxane and / or isostearic acid. It has been reported that the dispersion stability of the powder can be improved. Patent Document 2 discloses that in an oil-in-water emulsion composition, an oil layer contains a specific amount of silicone oil, an amphiphile having an HLB of 5 or less, and a specific acrylic silicone, whereby good dispersion stability is achieved in the powder. It has been reported that it can have sex. Patent Document 3 discloses that an oil-in-water emulsion composition containing an aqueous phase containing a copolymer of acryloyldimethyltaurine salt and hydroxyethyl acrylate and an oily phase containing powder improves the aggregation and sedimentation of the powder. It has been reported that it can be done. Patent Document 4 reports that the dispersion stability of a powder is improved by allowing the powder and a specific both-end silicone-modified glycerin to coexist in a cosmetic.
しかしながら、特許文献1〜4では、いずれも、非イオン性界面活性剤に該当する化合物を使用することにより、乳化組成物中での粉体の分散安定性を向上させているため、HLBのバランスが崩れた場合等で転相し易く、乳化安定性に影響を与えたり、配合できる成分が制約されたりするという欠点がある。更に、特許文献1〜4の製剤化技術では、粉体を多く配合する場合には、十分な分散安定性を確保できなくなることもある。 However, in Patent Documents 1 to 4, since the dispersion stability of the powder in the emulsion composition is improved by using a compound corresponding to a nonionic surfactant, the balance of HLB However, there is a drawback in that phase inversion easily occurs, and the emulsion stability is affected, and components that can be blended are restricted. Furthermore, in the formulation techniques of Patent Documents 1 to 4, when a large amount of powder is blended, sufficient dispersion stability may not be ensured.
このような従来技術を背景として、シワ及び/又は毛穴の隠蔽に使用される外用組成物において、粉体の分散安定性を向上させる新たな技術の開発が求められている。 Against the background of such a conventional technique, development of a new technique for improving the dispersion stability of powder in an external composition used for concealing wrinkles and / or pores is required.
本発明の目的は、シワ及び/又は毛穴の隠蔽に使用される外用組成物において、粉体の分散安定性を向上させる製剤化技術を提供することである。 The objective of this invention is providing the formulation technique which improves the dispersion stability of powder in the external composition used for concealing wrinkles and / or pores.
本発明者は、前記課題を解決すべく鋭意検討を行ったところ、シワ及び/又は毛穴の隠蔽に使用される外用組成物において、粉体と共にヘパリン類似物質を配合すると、粉体の分散安定性が著しく向上し、沈降、凝集、ダマの形成が抑制され、優れた製剤安定性を備え得ることを見出した。 As a result of diligent studies to solve the above problems, the present inventor has found that, in a composition for external use used for concealing wrinkles and / or pores, when a heparin-like substance is blended with the powder, the dispersion stability of the powder Has been found to be significantly improved, sedimentation, agglomeration, and formation of lumps are suppressed, and excellent formulation stability can be provided.
また、本発明者は、前記外用組成物に、更にアクリル酸デンプンを配合すると、粉体が毛穴やシワに入りこみ易くなり、更にシワや毛穴に入り込んだ粉体が皮膚に馴染んで本来の肌と似た質感を呈することができ、毛穴やシワに対して優れた隠蔽効果を奏し得ることを見出した。更に、当該外用組成物は、粉体がシワや毛穴に一旦入りこむと離脱し難くなり、隠蔽効果の持続性の点でも優れていることを見出した。 In addition, when the present inventor further blends starch acrylate with the composition for external use, the powder easily penetrates into pores and wrinkles, and the powder that has entered the wrinkles and pores becomes familiar with the skin and the original skin. It has been found that a similar texture can be exhibited and an excellent concealing effect can be exerted on pores and wrinkles. Furthermore, it was found that the composition for external use is difficult to remove once the powder enters the wrinkles and pores, and is excellent in the durability of the hiding effect.
本発明は、これらの知見に基づいて更に検討を重ねることにより、完成したものである。即ち、本発明は、下記に掲げる態様の発明を提供する。
項1. シワ及び/又は毛穴の隠蔽に使用される外用組成物であって、粉体、及びヘパリン類似物質を含有することを特徴とする、外用組成物。
項2. 前記粉体の平均粒子径が0.1〜30μmである、項1に記載の外用組成物。
項3. 更にアクリル酸澱粉を含む、項1又は2に記載の外用組成物。
項4. 前記粉体として、屈折率が1.3〜2.0の粉体及び屈折率が2.2〜2.8の粉体を含む、項1〜3のいずれかに記載の外用組成物。
項5. 前記粉体として、酸化鉄を含む、項1〜4のいずれかに記載の外用組成物。
The present invention has been completed by further studies based on these findings. That is, this invention provides the invention of the aspect hung up below.
Item 1. An external composition used for masking wrinkles and / or pores, comprising a powder and a heparin-like substance.
Item 2. Item 2. The external composition according to Item 1, wherein the powder has an average particle size of 0.1 to 30 µm.
Item 3. Item 3. The topical composition according to Item 1 or 2, further comprising starch acrylate.
Item 4. Item 4. The external composition according to any one of Items 1 to 3, comprising a powder having a refractive index of 1.3 to 2.0 and a powder having a refractive index of 2.2 to 2.8 as the powder.
Item 5. Item 5. The external composition according to any one of Items 1 to 4, comprising iron oxide as the powder.
本発明の外用組成物は、粉体の分散安定性が向上しているので、液状に製剤化した場合には粉体の沈降や凝集を抑制でき、また半固形状(クリーム状等)に製剤化した場合には、粉体が凝集したり、ダマになったりするのを抑制できるので、優れた製剤安定性を有している。 Since the composition for external use of the present invention has improved dispersion stability of the powder, when it is formulated into a liquid, it can suppress the sedimentation and aggregation of the powder, and it can be formulated into a semi-solid form (such as cream). In this case, since the powder can be prevented from agglomerating and becoming lumpy, it has excellent formulation stability.
更に、本発明の外用組成物の一態様では、粉体がシワや毛穴に入りこみ易くなり、更にシワや毛穴に入り込んだ粉体が皮膚に馴染んで本来肌と同じ質感を呈することができるので、シワや毛穴部分を本来の肌質と同じ質感に仕上げ、シワや毛穴を目立ち難くすることができる。また、本発明の外用組成物の一態様では、シワや毛穴に一旦入り込んだ粉体が離脱し難いため、日常生活における身体動作を行っても粉体がシワ部や毛穴部に保持され、シワや毛穴の隠蔽効果を持続させることができる。 Furthermore, in one aspect of the composition for external use of the present invention, the powder easily penetrates into wrinkles and pores, and the powder that has entered the wrinkles and pores can become familiar with the skin and exhibit the same texture as the original skin, Wrinkles and pores can be finished to the same texture as the original skin, making wrinkles and pores less noticeable. In addition, in one aspect of the composition for external use of the present invention, since the powder once entered into the wrinkles and pores is difficult to remove, the powder is held in the wrinkles and pores even when performing body movements in daily life. And the effect of concealing pores can be maintained.
本発明の外用組成物は、シワ及び/又は毛穴の隠蔽に使用される外用組成物であって、粉体、及びヘパリン類似物質を含有することを特徴とする。以下、本発明の外用組成物について詳述する。 The external composition of the present invention is an external composition used for concealing wrinkles and / or pores, and is characterized by containing a powder and a heparin-like substance. Hereinafter, the external composition of the present invention will be described in detail.
なお、本明細書において、「粉体侵入性」とは、シワや毛穴に対する粉体の入り込み易さを指し、「肌質感」とは、粉体が入りこんだシワや毛穴部分において、本来の肌部分と違和感なく視覚的に似た肌質を呈する外観状態を指し、「粉体保持性」とは、シワや毛穴に一旦入り込んだ粉体が離脱し難く、シワや毛穴において保持される特性を指す。 In this specification, “powder penetration” refers to the ease of powder penetration into wrinkles and pores, and “skin texture” refers to the original skin in the wrinkles and pores where the powder has entered. This refers to the appearance of skin that looks visually similar to the skin, and “powder retention” refers to the property that the powder once entered the wrinkles and pores is difficult to release and is retained in the wrinkles and pores. Point to.
粉体
本発明は、シワや毛穴を隠蔽するために、粉体を含有する。本発明で使用される粉体は、従来、外用組成物においてシワや毛穴の隠蔽目的で用いられている隠蔽性無機粉体であればよい。このような粉体として、具体的には、水や有機溶剤に対して溶解及び膨潤しない特性を有するもの、即ち、不溶性非膨潤性の粉体が挙げられる。
Powder The present invention contains powder in order to conceal wrinkles and pores. The powder used in the present invention may be any concealing inorganic powder conventionally used for the purpose of concealing wrinkles and pores in external compositions. Specific examples of such powders include powders that do not dissolve or swell in water or organic solvents, that is, insoluble and non-swellable powders.
不溶性非膨潤性の粉体の種類については、特に制限されないが、例えば、カオリン系粘土鉱物、パイロフィライト系粘土鉱物、雲母系粘土鉱物、緑泥石系粘土鉱物、焼成粘土鉱物、ゼオライト系粘土鉱物、金属酸化物等が挙げられる。 The type of insoluble non-swellable powder is not particularly limited. For example, kaolin clay mineral, pyrophyllite clay mineral, mica clay mineral, chlorite clay mineral, calcined clay mineral, zeolite clay mineral And metal oxides.
カオリン系粘土鉱物としては、具体的には、カオリン(カオリナイト)、ハロイサイト、ナクライト、デッカイト、クリソタイル等が挙げられる。 Specific examples of kaolin clay minerals include kaolin (kaolinite), halloysite, nacrite, dickite, and chrysotile.
パイロフィライト系粘土鉱物としては、具体的には、タルク、パイロフィライト等が挙げられる。 Specific examples of the pyrophyllite clay mineral include talc and pyrophyllite.
雲母系粘土鉱物としては、具体的には、四角雲母(マイカ)、絹雲母(セリサイト)、白雲母(マスコバイト)、金雲母(フロゴバイト)、合成雲母、紅雲母(リチア雲母)、黒雲母(バイオタイト)等が挙げられる。 Specific examples of mica-based clay minerals include quadrilateral mica (mica), sericite (sericite), muscovite (mascobite), phlogopite (phlogobite), synthetic mica, safica (lithia mica), biotite. (Biotite) and the like.
緑泥石系粘土鉱物としては、具体的には、クロライト等を好ましく用いることができる。 Specifically, chlorite or the like can be preferably used as the chlorite clay mineral.
焼成粘土鉱物としては、具体的には、焼成雲母、焼成タルク、焼成セリサイト等が挙げられる。 Specific examples of the calcined clay mineral include calcined mica, calcined talc, calcined sericite, and the like.
ゼオライト系粘土鉱物としては、具体的には、天然ゼオライト、合成ゼオライト等が挙げられる。 Specific examples of the zeolitic clay mineral include natural zeolite and synthetic zeolite.
金属酸化物としては、具体的には、酸化鉄(赤酸化鉄(三二酸化鉄、ベンガラ)、黄酸化鉄、黄色三二酸化鉄、黒酸化鉄)、酸化亜鉛(亜鉛華)、酸化ジルコニウム、酸化チタン、酸化アルミニウム、酸化マグネシウム、シリカ、二酸化ケイ素、二酸化ケイ素・アルミナ複合化粉体、二酸化ケイ素・マグネシウム複合化粉体等が挙げられる。 Specific examples of metal oxides include iron oxide (red iron oxide (iron trioxide, bengara), yellow iron oxide, yellow ferric oxide, black iron oxide), zinc oxide (zinc white), zirconium oxide, oxidation Examples thereof include titanium, aluminum oxide, magnesium oxide, silica, silicon dioxide, silicon dioxide / alumina composite powder, and silicon dioxide / magnesium composite powder.
これらの粉体の中でも、分散安定性をより一層向上させるという観点から、或は、後述するアクリル酸デンプンを配合した際に達成される粉体侵入性、肌質感、及び粉体保持性の向上をより一層顕著ならしめるという観点から、好ましくは酸化チタン、二酸化ケイ素、タルク、カオリン、酸化鉄が挙げられる。 Among these powders, from the viewpoint of further improving the dispersion stability, or improved powder penetration, skin texture and powder retention achieved when blended with starch acrylate described later From the viewpoint of making the material more prominent, titanium oxide, silicon dioxide, talc, kaolin, and iron oxide are preferable.
また、これらの粉体は、必要に応じて、表面処理が施され、表面特性が改質されていてもよい。 In addition, these powders may be subjected to surface treatment as necessary, and the surface characteristics may be modified.
本発明に使用される粉体の平均粒子径については、シワや毛穴に対する隠蔽効果を奏し得ることを限度として特に制限されないが、例えば、0.1〜30μmが挙げられる。粉体の侵入性をより一層向上させるという観点から、粉体の平均粒子径として、好ましくは0.1〜20μm、更に好ましくは0.1〜15μm、特に好ましくは0.1〜10μm、最も好ましくは0.1〜5μmが挙げられる。従来技術では、このような平均粒子径の粉体は、粉体の保持特性が劣る傾向があったが、本発明の外用組成物では、このような平均粒子径の粉体であっても、後述するアクリル酸デンプンを配合することによって優れた粉体の保持特性を備えさせることが可能になる。なお、粉体の平均粒子径はレーザー回析・散乱法にて測定される値(D50)である。 Although it does not restrict | limit especially about the average particle diameter of the powder used for this invention as long as it can show the concealment effect with respect to a wrinkle or a pore, For example, 0.1-30 micrometers is mentioned. From the viewpoint of further improving the penetration of the powder, the average particle diameter of the powder is preferably 0.1 to 20 μm, more preferably 0.1 to 15 μm, particularly preferably 0.1 to 10 μm, most preferably. Is 0.1 to 5 μm. In the prior art, the powder having such an average particle size tended to have poor powder retention characteristics. However, in the composition for external use of the present invention, even if the powder has such an average particle size, By blending starch acrylate described later, it is possible to provide excellent powder retention characteristics. The average particle diameter of the powder is a value (D50) measured by a laser diffraction / scattering method.
本発明の外用組成物において、粉体は、1種単独で又は2種以上組み合わせて使用してもよく、使用する粉体の種類は、付与すべき肌質感の程度等に応じて適宜選定すればよい。 In the composition for external use of the present invention, the powder may be used singly or in combination of two or more, and the kind of the powder to be used is appropriately selected according to the degree of skin texture to be imparted and the like. That's fine.
例えば、酸化鉄は、ヘパリン類似物質と共存させることにより、色調が明るくなり、発色性が向上するので、本発明の外用組成物にヘパリン類似物質が含まれる場合には、酸化鉄は、肌質感を更に高め、シワをより一層目立たなくする上で特に好適である。 For example, when iron oxide coexists with a heparin-like substance, the color tone becomes brighter and color developability is improved. Therefore, when the composition for external use of the present invention contains a heparin-like substance, the iron oxide has a skin texture. It is particularly suitable for further increasing the wrinkle and making the wrinkles less noticeable.
例えば、屈折率が2.0以下、好ましくは1.3〜2.0程度の粉体(以下、低屈折率粉体と表記することもある)は、シワや毛穴に入り込んで透明感を呈し、自然な印象を与えることができるので、透明感に優れた肌質感を付与することを重視する場合には、好適に使用される。屈折率が1.3〜2.0程度の粉体としては、具体的には、二酸化ケイ素、タルク、カオリン等が挙げられる。 For example, a powder having a refractive index of 2.0 or less, preferably about 1.3 to 2.0 (hereinafter sometimes referred to as a low refractive index powder) enters a wrinkle or a pore and exhibits transparency. Since it can give a natural impression, it is preferably used when it is important to give a skin texture excellent in transparency. Specific examples of the powder having a refractive index of about 1.3 to 2.0 include silicon dioxide, talc, and kaolin.
例えば、屈折率が2.0超、好ましくは2.2〜2.8程度の粉体(以下、高屈折率粉体と表記することもある)は、シワや毛穴の周辺の皮膚色に馴染み易く、粉体が入り込んだシワや毛穴部分の違和感を低減させることができので、周辺の皮膚色との違和感の低減を重視する場合には、好適に使用される。屈折率が2.2〜2.8程度の粉体としては、具体的には、酸化チタン等が挙げられる。 For example, powder having a refractive index of more than 2.0, preferably about 2.2 to 2.8 (hereinafter sometimes referred to as high refractive index powder) is familiar with the skin color around wrinkles and pores. It is easy to use and can reduce the uncomfortable feeling of wrinkles and pores containing the powder. Therefore, it is preferably used when importance is placed on reducing the uncomfortable feeling with the surrounding skin color. Specific examples of the powder having a refractive index of about 2.2 to 2.8 include titanium oxide.
また、本発明で使用される粉体の好適な一態様として、低屈折率粉体と高屈折率粉体の組み合わせが挙げられる。低屈折率粉体と高屈折率粉体を併用することによって、透明感に優れ、しかも周辺の皮膚色との違和感が低減された肌質感を実現することが可能になる。低屈折率粉体と高屈折率粉体を組み合わせて使用する場合、これらの比率については、特に制限されないが、例えば、低屈折率粉体100重量部当たり、高屈折率粉体が5〜300重量部、好ましくは10〜200重量部、更に好ましくは10〜150重量部が挙げられる。 Further, as a preferred embodiment of the powder used in the present invention, a combination of a low refractive index powder and a high refractive index powder can be mentioned. By using the low refractive index powder and the high refractive index powder in combination, it is possible to realize a skin texture that is excellent in transparency and has a reduced discomfort with the surrounding skin color. When the low refractive index powder and the high refractive index powder are used in combination, these ratios are not particularly limited. For example, the high refractive index powder is 5 to 300 per 100 parts by weight of the low refractive index powder. Part by weight, preferably 10 to 200 parts by weight, and more preferably 10 to 150 parts by weight.
本発明の外用組成物における粉体の含有量については、特に制限されないが、例えば、1〜25重量%程度、好ましくは1〜20重量%程度、更に好ましくは1〜15重量%程度、特に好ましくは1〜10重量%程度が挙げられる。 The content of the powder in the composition for external use of the present invention is not particularly limited, but is, for example, about 1 to 25% by weight, preferably about 1 to 20% by weight, more preferably about 1 to 15% by weight, and particularly preferably. Is about 1 to 10% by weight.
ヘパリン類似物質
本発明の外用組成物は、ヘパリン類似物質を含有する。本発明の外用組成物では、ヘパリン類似物質によって、粉体の分散安定性の向上が図られ、沈降、凝集、ダマの形成等を抑制することが可能になる。また、粉体の分散安定性を向上させることにより、皮膚に塗布した際にシワや毛穴において粉体侵入性を均一にすることも可能になる。
Heparin analog The external composition of the present invention contains a heparin analog. In the composition for external use of the present invention, the dispersion stability of the powder is improved by the heparin-like substance, and sedimentation, aggregation, formation of lumps, and the like can be suppressed. Further, by improving the dispersion stability of the powder, it becomes possible to make the powder penetration uniform in wrinkles and pores when applied to the skin.
ヘパリン類似物質とは、コンドロイチン多硫酸等の多硫酸化ムコ多糖であり、保湿作用、抗炎症作用、血行促進作用等を有することが知られている公知の薬剤である。 Heparin-like substances are polysulfated mucopolysaccharides such as chondroitin polysulfate and are known drugs known to have moisturizing action, anti-inflammatory action, blood circulation promoting action, and the like.
本発明で使用されるヘパリン類似物質の由来については、特に制限されないが、例えば、ムコ多糖類を多硫酸化することにより得られたもの、食用獣の組織(例えば、ウシやブタ等の気管軟骨を含む肺臓)から抽出したもの等が挙げられる。本発明の外用組成物では、ヘパリン類似物質として、日本薬局方外医薬品規格に収戴されているヘパリン類似物質が好適に使用される。 The origin of the heparin-like substance used in the present invention is not particularly limited. For example, it is obtained by polysulfating mucopolysaccharides, tissues of edible animals (for example, tracheal cartilage such as cattle and pigs) And the like extracted from the lung including In the composition for external use of the present invention, as the heparin-like substance, a heparin-like substance included in the Japanese Pharmacopoeia pharmaceutical standards is preferably used.
本発明の外用組成物において、ヘパリン類似物質の含有量については、特に制限されないが、例えば、0.1重量%以上、好ましくは0.1〜1重量%、更に好ましくは0.1〜0.5重量%が挙げられる。 In the composition for external use of the present invention, the content of the heparin-like substance is not particularly limited, but for example, 0.1% by weight or more, preferably 0.1 to 1% by weight, and more preferably 0.1 to 0. 5% by weight.
また、本発明の外用組成物において、粉体に対するヘパリン類似物質の比率については、特に制限されないが、例えば、粉体100重量部当たり、ヘパリン類似物質が、0.1重量部以上、好ましくは0.1〜500重量部、更に好ましくは0.2〜300重量部、特に好ましくは0.2〜200重量部が挙げられる。 In the composition for external use of the present invention, the ratio of the heparin-like substance to the powder is not particularly limited. For example, the heparin-like substance is 0.1 parts by weight or more, preferably 0, per 100 parts by weight of the powder. 0.1 to 500 parts by weight, more preferably 0.2 to 300 parts by weight, and particularly preferably 0.2 to 200 parts by weight.
アクリル酸デンプン
本発明の外用組成物は、必要に応じて、アクリル酸デンプンを含むことができる。本発明の外用組成物では、粉体及びヘパリン類似物質と共にとアクリル酸デンプンを含むことによって、粉体侵入性、肌質感、及び粉体保持性を向上させることができ、優れた隠蔽効果を持続的に奏させることが可能になる。限定的な解釈を望むものではないが、本発明の外用組成物においてアクリル酸デンプンを含む場合には、皮膚に塗布された粉体がアクリル酸デンプンで覆われていることにより、粉体による表面の凹凸が均一になり、それによって、粉体侵入性が高まると共に、粉体に入射する光や粉体から反射する光をより均一にすることにより肌質感を向上させることが可能になっていると考えられる。また、本発明の外用組成物が塗布されたシワや毛穴部分がアクリル酸デンプンによって覆われ、粉体保持性が向上すると考えられる。
Starch Acrylate The composition for external use of the present invention may contain starch acrylate as required. In the composition for external use of the present invention, by including starch and acrylate together with powder and heparin-like substance, powder penetration, skin texture, and powder retention can be improved, and excellent concealment effect is maintained. Can be played. Although a limited interpretation is not desired, when the composition for external use of the present invention contains starch acrylate, the powder-coated surface is covered with the starch acrylate coated with the starch. As a result, the texture of the skin can be improved by making the light entering the powder and the light reflected from the powder more uniform. it is conceivable that. Moreover, it is thought that the wrinkle and pore part to which the composition for external use of this invention was apply | coated are covered with starch acrylate, and powder retention property improves.
アクリル酸デンプンとは、デンプンがアクリル酸によって化学修飾されているデンプン誘導体である。本発明に使用されるアクリル酸デンプンの種類については、特に制限されないが、例えば、アクリル酸デンプン300、アクリル酸デンプン1000、デンプン・アクリル酸ナトリウムグラフト重合体等が挙げられる。これらのアクリル酸デンプンの中でも、粉体侵入性、肌質感、及び粉体保持性をより一層向上させるという観点から、好ましくはアクリル酸デンプン300、アクリル酸デンプン1000、更に好ましくはアクリル酸デンプン1000が挙げられる。 Starch acrylate is a starch derivative in which starch is chemically modified with acrylic acid. The type of starch acrylate used in the present invention is not particularly limited, and examples thereof include starch acrylate 300, starch acrylate 1000, starch / sodium acrylate graft polymer, and the like. Among these starch acrylates, from the viewpoint of further improving powder penetration, skin texture, and powder retention, preferably starch acrylate 300, starch acrylate 1000, more preferably starch acrylate 1000. Can be mentioned.
また、アクリル酸デンプンを構成する原料デンプンの種類については、特に制限されないが、例えば、トウモロコシデンプン、小麦デンプン、馬鈴薯デンプン、タピオカデンプン、米デンプン、甘藷デンプン、サゴデンプン、ソラマメデンプン、緑豆デンプン、大豆デンプン、小豆デンプン等が挙げられる。 In addition, the type of raw material starch constituting the acrylate starch is not particularly limited. And red bean starch.
これらのアクリル酸デンプンは、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 These starch acrylates may be used individually by 1 type, and may be used in combination of 2 or more type.
アクリル酸デンプンは、公知の方法により調製したものを使用してもよく、また市販品を使用してもよい。アクリル酸デンプンの市販品としては、例えば、アクリル酸デンプン300としては、商品名「サンウェットIM−300MPS」(三洋化成工業株式会社製);アクリル酸デンプン1000としては、商品名「サンウェットIM−1000」、商品名「サンウェットサンウェットIM−1000MPS」(いずれも三洋化成工業株式会社製);デンプン・アクリル酸ナトリウムグラフト重合体としては、商品名「サンフレッシュST−100MC」(三洋化成工業株式会社製)等が挙げられる。 As the starch acrylate, one prepared by a known method may be used, or a commercially available product may be used. As a commercial product of starch acrylate, for example, as the starch acrylate 300, trade name “Sunwet IM-300MPS” (manufactured by Sanyo Chemical Industries Ltd.); as the starch acrylate 1000, trade name “Sunwet IM- 1000 ”, trade name“ Sunwet Sunwet IM-1000MPS ”(both manufactured by Sanyo Chemical Industries, Ltd.); as a starch / sodium acrylate graft polymer, trade name“ Sunfresh ST-100MC ”(Sanyo Chemical Industries Co., Ltd.) Company-made).
本発明の外用組成物において、アクリル酸デンプンを含有させる場合、その含有量については、特に制限されないが、例えば、0.1〜10重量%が挙げられる。粉体侵入性、肌質感、及び粉体保持性をより一層向上させるという観点から、本発明の外用組成物におけるアクリル酸デンプンの含有量として、好ましくは、0.1〜5重量%、更に好ましくは0.1〜3重量%、特に好ましくは0.1〜2重量%、最も好ましくは0.1〜1重量%が挙げられる。 In the composition for external use of the present invention, when starch acrylate is contained, the content thereof is not particularly limited, and examples thereof include 0.1 to 10% by weight. From the viewpoint of further improving powder penetration, skin texture, and powder retention, the content of starch acrylate in the composition for external use of the present invention is preferably 0.1 to 5% by weight, more preferably Is 0.1 to 3% by weight, particularly preferably 0.1 to 2% by weight, and most preferably 0.1 to 1% by weight.
本発明の外用組成物において、アクリル酸デンプンを含有させる場合、粉体に対するアクリル酸デンプンの比率については、特に制限されないが、例えば、粉体100重量部当たり、アクリル酸デンプンが、1〜200重量部、好ましくは2〜150重量部、更に好ましくは5〜100重量部が挙げられる。 In the composition for external use of the present invention, when the starch acrylate is contained, the ratio of the starch acrylate to the powder is not particularly limited. For example, the starch acrylate is 1 to 200 weights per 100 parts by weight of the powder. Parts, preferably 2 to 150 parts by weight, more preferably 5 to 100 parts by weight.
増粘剤
本発明の外用組成物は、適度な粘度を付与して使用感を高めるために、増粘剤が含まれていてもよい。
Thickener The composition for external use of the present invention may contain a thickener in order to impart an appropriate viscosity and enhance the feeling of use.
増粘剤の種類については、香粧学的に許容されることを限度として特に制限されないが、例えば、カルボキシビニルポリマー、ヒドロキシプロピルメチルセルロース、カルボキシメチルセルロースナトリウム、エチルセルロース、メチルセルロース、アルギン酸ナトリウム、キサンタンガム、カラギーナン、ポリビニルピロリドン等が挙げられる。これらの増粘剤の中でも、好ましくはカルボキシビニルポリマーが挙げられる。 The type of thickener is not particularly limited as long as it is cosmetically acceptable, but for example, carboxyvinyl polymer, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, ethylcellulose, methylcellulose, sodium alginate, xanthan gum, carrageenan, Polyvinyl pyrrolidone etc. are mentioned. Among these thickeners, carboxyvinyl polymer is preferable.
これらの増粘剤は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 These thickeners may be used individually by 1 type, and may be used in combination of 2 or more type.
本発明の外用組成物に増粘剤を含有させる場合、その含有量については、特に制限されないが、例えば、0.1〜5重量%、好ましくは0.1〜2重量%、更に好ましくは0.1〜1重量%が挙げられる。 When the thickening agent is contained in the external composition of the present invention, the content is not particularly limited, but is, for example, 0.1 to 5% by weight, preferably 0.1 to 2% by weight, and more preferably 0. 0.1 to 1% by weight.
水
本発明の外用組成物は、ヘパリン類似物質を溶解させた状態にして、粉体分散安定性を効果的に向上させるために、水が含まれていることが好ましい。本発明の外用組成物において水を含有させる場合、その含有量については、特に制限されないが、例えば30重量%以上、好ましくは30〜95重量%、更に好ましくは40〜95重量%が挙げられる。
Composition for external use of the water present invention, in the state of being dissolved heparinoid, in order to effectively improve the powder dispersion stability, it preferably contains water. When water is contained in the composition for external use of the present invention, the content is not particularly limited, but for example, 30% by weight or more, preferably 30 to 95% by weight, more preferably 40 to 95% by weight.
油分
本発明の外用組成物は、皮膚に塗布した際の使用感の向上等のために、油分が含まれていてもよい。
Oil content The composition for external use of the present invention may contain an oil content in order to improve the feeling of use when applied to the skin.
油分の種類については、香粧学的に許容されることを限度として特に制限されないが、例えば、オリーブ油、サフラワー油、大豆油、つばき油、とうもろこし油、なたね油、ひまわり油、綿実油、落花生油、ラード、スクワラン、魚油等の動植物油;流動パラフィン、パラフィン、ゲル化炭化水素、ワセリン等の鉱物油;ミツロウ、カルナウバロウ、キャンデリラロウ、セレシン、ライスワックス、マイクロクリスタリンワックス等のワックス類・ロウ類;ミリスチン酸イソプロピル、アジピン酸イソプロピル、セバシン酸ジエチル、セバシン酸イソプロピル、パルミチン酸イソプロピル、パルミチン酸セチル、オレイン酸エチル等のエステル油;ステアリン酸、オレイン酸、パルミチン酸、ベヘン酸、リノール酸、ラノリン等の脂肪酸;パルミチン酸セチル、パルミチン酸イソプロピル、リノール酸エチル等の脂肪酸エステル;ステアリルアルコール、セタノール、ベヘニルアルコール、ミリスチルアルコール、オレイルアルコール、ヘキサデシルアルコール、ラノリンアルコール等の高級アルコール;ジメチルポリシロキサン、環状シリコーン等のシリコーンオイル;コレステロール、トリ2−エチルヘキサン酸グリセリル、2−エチルヘキサン酸セチル等が挙げられる。これらの油分は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 The type of oil is not particularly limited as long as it is cosmetically acceptable. For example, olive oil, safflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, sunflower oil, cottonseed oil, peanut oil, Animal and vegetable oils such as lard, squalane and fish oil; mineral oils such as liquid paraffin, paraffin, gelled hydrocarbon and petrolatum; waxes and waxes such as beeswax, carnauba wax, candelilla wax, ceresin, rice wax and microcrystalline wax; Ester oil such as isopropyl myristate, isopropyl adipate, diethyl sebacate, isopropyl sebacate, isopropyl palmitate, cetyl palmitate, ethyl oleate; stearic acid, oleic acid, palmitic acid, behenic acid, linoleic acid, lanolin, etc. Fatty acid; Fatty acid esters such as cetyl mitinate, isopropyl palmitate and ethyl linoleate; higher alcohols such as stearyl alcohol, cetanol, behenyl alcohol, myristyl alcohol, oleyl alcohol, hexadecyl alcohol and lanolin alcohol; silicone oils such as dimethylpolysiloxane and cyclic silicone Cholesterol, glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate and the like. These oil components may be used alone or in combination of two or more.
本発明の外用組成物に油分を含有させる場合、その含有量については、製剤形態等に応じて適宜設定すればよいが、例えば、1〜50重量%、好ましくは5〜50重量%が挙げられる。 When the oil composition is contained in the external composition of the present invention, the content thereof may be appropriately set according to the formulation form and the like, for example, 1 to 50% by weight, preferably 5 to 50% by weight. .
界面活性剤
また、本発明の外用組成物は、必要に応じて、界面活性剤が含まれていてもよい。特に、本発明の外用組成物に油分を配合する場合であれば、油分を可溶化又は乳化させるために界面活性剤が含まれていることが望ましい。
Surfactant Moreover, the composition for external use of the present invention may contain a surfactant, if necessary. In particular, when an oil component is blended in the composition for external use of the present invention, it is desirable that a surfactant is contained in order to solubilize or emulsify the oil component.
界面活性剤としては、香粧学的に許容されることを限度として特に制限されず、ノニオン性界面活性剤、アニオン性界面活性剤、カチオン性界面活性剤、両性界面活性剤のいずれを使用してもよいが、好ましくはノニオン性界面活性剤が挙げられる。 The surfactant is not particularly limited as long as it is cosmetically acceptable, and any of nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants can be used. However, a nonionic surfactant is preferable.
界面活性剤としては、具体的には、POE(10〜50モル)フィトステロールエーテル、POE(10〜50モル)ジヒドロコレステロールエーテル、POE(10〜50モル)2−オクチルドデシルエーテル、POE(10〜50モル)デシルテトラデシルエーテル、POE(10〜50モル)オレイルエーテル、POE(2〜50モル)セチルエーテル、POE(5〜50モル)ベヘニルエーテル、POE(5〜30モル)ポリオキシプロピレン(5〜30モル)2−デシルテトラデシルエーテル、POE(10〜50モル)ポリオキシプロピレン(2〜30モル)セチルエーテル等のポリオキシエチレンアルキルエーテル、これらのリン酸・リン酸塩(POEセチルエーテルリン酸ナトリウムなど)、POE(20〜60モル)ソルビタンモノオレート、POE(10〜60モル)ソルビタンモノイソステアレート、POE(10〜80モル)グリセリルモノイソステアレート、POE(10〜30モル)グリセリルモノステアレート、POE(20〜100モル)・ポリオキシプロピレン変性シリコーン、POE・アルキル変性シリコーン、モノラウリン酸ポリエチレングリコール、モノパルミチン酸ポリエチレングリコール、モノステアリン酸ポリエチレングリコール、ジラウリン酸ポリエチレングリコール、ジパルミチン酸ポリエチレングリコール、ジステアリン酸ポリエチレングリコール、ジオレイン酸ポリエチレングリコール、ジリシノレイン酸ポリエチレングリコール、ポリオキシエチレン硬化ヒマシ油(5〜100)、ポリソルベート(20〜85)、グリセリン脂肪酸エステル(モノステアリン酸グリセリン等)、水素添加大豆リン脂質、水素添加ラノリンアルコール、脂肪酸ポリグリセリル(ステアリン酸ポリグリセリル等)、アミノ酸と脂肪酸のアミド結合物(ステアロイルグルタミン酸ナトリウム等)が挙げられる。これらの界面活性剤は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Specific examples of the surfactant include POE (10-50 mol) phytosterol ether, POE (10-50 mol) dihydrocholesterol ether, POE (10-50 mol) 2-octyldodecyl ether, POE (10-50 mol). Mol) decyltetradecyl ether, POE (10-50 mol) oleyl ether, POE (2-50 mol) cetyl ether, POE (5-50 mol) behenyl ether, POE (5-30 mol) polyoxypropylene (5-5 mol) 30 mol) Polyoxyethylene alkyl ethers such as 2-decyltetradecyl ether, POE (10 to 50 mol) polyoxypropylene (2 to 30 mol) cetyl ether, phosphoric acid / phosphate thereof (POE cetyl ether phosphoric acid) Sodium), POE (20-60 mol) sol Tan monooleate, POE (10-60 mol) sorbitan monoisostearate, POE (10-80 mol) glyceryl monoisostearate, POE (10-30 mol) glyceryl monostearate, POE (20-100 mol) Polyoxypropylene modified silicone, POE / alkyl modified silicone, polyethylene glycol monolaurate, polyethylene glycol monopalmitate, polyethylene glycol monostearate, polyethylene glycol dilaurate, polyethylene glycol dipalmitate, polyethylene glycol distearate, polyethylene glycol dioleate, Polyglycol diricinoleate, polyoxyethylene hydrogenated castor oil (5-100), polysorbate (20-85), grease Phosphorus fatty acid ester (glyceryl monostearate etc.), hydrogenated soybean phospholipid, hydrogenated lanolin alcohol, fatty acid polyglyceryl (polyglyceryl stearate, etc.), an amide bond of an amino acid and a fatty acid (sodium stearoyl glutamate, etc.). These surfactants may be used individually by 1 type, and may be used in combination of 2 or more type.
本発明の外用組成物に、界面活性剤を含有させる場合、その含有量については、製剤形態等に応じて適宜設定すればよいが、例えば、0.1〜10重量%、好ましくは0.1〜8重量%、更に好ましくは0.1〜5重量%が挙げられる。 When the surfactant is contained in the composition for external use of the present invention, the content thereof may be appropriately set according to the formulation form and the like, for example, 0.1 to 10% by weight, preferably 0.1 -8 wt%, more preferably 0.1-5 wt%.
その他の成分
本発明の外用組成物は、前述する成分の他に、必要に応じて、香粧学的又は薬学的な機能性を示す機能性成分が含まれていてもよい。このような機能性成分としては、特に制限されないが、例えば、水溶性のビタミン及びその誘導体、油溶性のビタミン及びその誘導体、グリチルリチン酸及びその誘導体、グリチルレチン酸及びその誘導体、アスタキサンチン、コエンザイムQ10、α−リポ酸、セラミド又はその類似物質、リノール酸、アルブチン、トラネキサム酸、コウジ酸、酵素、ペプチド、ホルモン、各種サイトカイン、ヒアルロン酸等のグリコサミノグリカン類及びその塩類或いはその誘導体、ヒアルロン酸加水分解物、コラーゲン又はその加水分解物、エラスチン又はその加水分解物、糖類等の生理活性物質、各種動植物抽出物、微生物による発酵で得られる物質、ステロイド剤、抗ヒスタミン、局所麻酔剤、抗炎症剤、抗菌剤、抗菌剤、鎮痒剤、皮膚保護剤、血行促進剤、ステロール類等が挙げられる。これらの機能性成分を含有させる場合、その含有量については、使用する機能性成分の種類、期待する効果等に応じて適宜設定すればよい。
Other Components The composition for external use of the present invention may contain a functional component exhibiting cosmetic or pharmaceutical functionality, if necessary, in addition to the components described above. Such functional components are not particularly limited, and examples thereof include water-soluble vitamins and derivatives thereof, oil-soluble vitamins and derivatives thereof, glycyrrhizic acid and derivatives thereof, glycyrrhetinic acid and derivatives thereof, astaxanthin, coenzyme Q10, α -Lipoic acid, ceramide or similar substances, linoleic acid, arbutin, tranexamic acid, kojic acid, enzymes, peptides, hormones, various cytokines, hyaluronic acid and other glycosaminoglycans and their salts or derivatives, hyaluronic acid hydrolysis Products, collagen or hydrolysates thereof, elastin or hydrolysates thereof, physiologically active substances such as sugars, various animal and plant extracts, substances obtained by fermentation by microorganisms, steroids, antihistamines, local anesthetics, anti-inflammatory agents, Antibacterial agent, antibacterial agent, antipruritic agent, skin protectant, Row promoter, sterols and the like. When these functional components are contained, the content may be appropriately set according to the type of functional component to be used, the expected effect, and the like.
また、本発明の外用組成物は、所望の製剤形態にするために、必要に応じて、前述する成分以外の添加剤が含まれていてもよい。このような添加剤については、香粧学的に許容されることを限度として特に制限されないが、例えば、多価アルコール(エチレングリコール、プロピレングリコール、イソプレングリコール、ジエチレングリコール、ジプロピレングリコール、ポリプロピレングリコール、グリセリン等)、一価の低級アルコール(エタノール、プロパノール、イソプロパノール、ブタノール、イソブタノール等)、清涼化剤(メントール、カンフル、ボルネオール、ハッカ水、ハッカ油等)、防腐剤(メチルパラベン、プロピルパラベン、安息香酸、安息香酸ナトリウム、ソルビン酸等)、着香剤(シトラール、1,8−シオネール、シトロネラール、ファルネソール等)、着色剤(タール色素(褐色201号、青色201号、黄色4号、黄色403号等)、カカオ色素、クロロフィル、酸化アルミニウム等)、pH調整剤(リン酸、塩酸、クエン酸、クエン酸ナトリウム、コハク酸、酒石酸、水酸化ナトリウム、水酸化カリウム、トリエタノールアミン、トリイソプロパノールアミン等)、湿潤剤(dl−ピロリドンカルボン酸ナトリウム液、D−ソルビトール液、マクロゴール等)、安定化剤(ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、エデト酸ナトリウム、メタリン酸ナトリウム、L−アルギニン、L−アスパラギン酸、DL−アラニン、グリシン、エリソルビン酸ナトリウム、没食子酸プロピル、亜硫酸ナトリウム、二酸化硫黄、クロロゲン酸、カテキン、ローズマリー抽出物等)、酸化防止剤、紫外線吸収剤、キレート剤、粘着剤、緩衝剤、溶解補助剤、可溶化剤、保存剤等の添加剤が挙げられる。 Moreover, in order to make the external composition of this invention into a desired formulation form, additives other than the component mentioned above may be contained as needed. Such additives are not particularly limited as long as they are cosmetically acceptable. For example, polyhydric alcohols (ethylene glycol, propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, glycerin) Etc.), monovalent lower alcohols (ethanol, propanol, isopropanol, butanol, isobutanol, etc.), cooling agents (menthol, camphor, borneol, mint water, mint oil, etc.), preservatives (methylparaben, propylparaben, benzoic acid, etc.) , Sodium benzoate, sorbic acid, etc.), flavoring agents (citral, 1,8-shionale, citronellal, farnesol, etc.), coloring agents (tar pigments (brown 201, blue 201, yellow 4, yellow 403, etc.) ) Cocoa pigment, chlorophyll, aluminum oxide, etc.), pH adjuster (phosphoric acid, hydrochloric acid, citric acid, sodium citrate, succinic acid, tartaric acid, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine, etc.), wet Agents (dl-pyrrolidone carboxylate solution, D-sorbitol solution, macrogol, etc.), stabilizers (dibutylhydroxytoluene, butylhydroxyanisole, sodium edetate, sodium metaphosphate, L-arginine, L-aspartic acid, DL -Alanine, glycine, sodium erythorbate, propyl gallate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract, etc.), antioxidants, UV absorbers, chelating agents, adhesives, buffers, dissolution aids Agent, solubilizer, Additives such as presence agents.
製剤形態・用途
本発明の外用組成物は、経皮適用される製剤(化粧料、外用医薬品(医薬部外品を含む)等)として使用される。
Formulation Form / Use The composition for external use of the present invention is used as a preparation (cosmetics, external medicine (including quasi drugs), etc.) applied transdermally.
本発明の外用組成物の剤型については、特に制限されず、液状(懸濁液、乳化液等)、半固形状(クリーム、軟膏、ジェル等)、又は固形状のいずれであってもよいが、好ましくは液状及び半固形状が挙げられる。 The dosage form of the external composition of the present invention is not particularly limited and may be liquid (suspension, emulsion, etc.), semi-solid (cream, ointment, gel, etc.), or solid. However, liquid and semi-solid forms are preferable.
本発明の外用組成物の製剤形態については、経皮適用可能であることを限度として特に制限されず、例えば、メイクアップ化粧料(ファンデーション、コンシーラー、チーク等)、クリーム、化粧水、美容液、乳液、ジェル、口紅、ファンデーション等の化粧料;液剤(ローション剤、スプレー剤、エアゾール剤、及び乳液剤を含む)、フォーム剤、軟膏剤、クリーム剤、ジェル剤等の外用医薬品が挙げられる。これらの製剤形態の中でも、好ましくは化粧料、更に好ましくは、クリーム、化粧水、美容液、乳液、ジェル等が挙げられる。 The preparation form of the composition for external use of the present invention is not particularly limited as long as it can be applied transdermally. For example, makeup cosmetics (foundation, concealer, teak, etc.), cream, lotion, cosmetic liquid, Cosmetics such as emulsions, gels, lipsticks, foundations; and external medicines such as liquids (including lotions, sprays, aerosols, and emulsions), foams, ointments, creams, gels. Among these preparation forms, cosmetics are preferable, and creams, skin lotions, serums, emulsions, gels, and the like are more preferable.
本発明の外用組成物は、シワ及び/又は毛穴の隠蔽(シワ隠し及び/又は毛穴隠し)用途に使用される。本発明の外用組成物が適用される部位については、特に制限されず、シワが生じている部位、及び/又は毛穴が目立つ部位であればよいが、例えば、顔、首、手、腕、足等が挙げられる。 The external composition of the present invention is used for wrinkle and / or pore concealment (wrinkle concealment and / or pore concealment). The site to which the composition for external use of the present invention is applied is not particularly limited, and may be a site where wrinkles are generated and / or a site where pores are conspicuous. For example, the face, neck, hand, arm, foot Etc.
以下に、実施例等を示して本発明をより具体的に説明するが、本発明はこれらに限定されるものではない。 EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples and the like, but the present invention is not limited to these.
なお、以下の実施例、比較例、及び処方例において、アクリル酸デンプン1000は商品名「サンウェットサンウェットIM−1000MPS」(三洋化成工業株式会社製)、アクリル酸デンプン300は商品名「サンウェットIM−300MPS」(三洋化成工業株式会社製)、デンプン・アクリル酸ナトリウムグラフト重合体は商品名「サンフレッシュST−100MC」(三洋化成工業株式会社製)を使用した。 In the following examples, comparative examples, and formulation examples, starch acrylate 1000 is trade name “Sunwet Sunwet IM-1000MPS” (manufactured by Sanyo Chemical Industries Ltd.), and acrylate starch 300 is trade name “Sunwet”. “IM-300MPS” (manufactured by Sanyo Chemical Industries, Ltd.) and starch / sodium acrylate graft polymer used the trade name “Sunfresh ST-100MC” (manufactured by Sanyo Chemical Industries, Ltd.).
試験例1
1.外用組成物(懸濁液)の調製
表1に示す組成の外用組成物(懸濁液)を調製した。具体的には、先ず、精製水にヘパリン類似物質及びアクリル酸デンプン1000を加えて溶解させた。次いで、表1に示す各粉体を加えて混合することにより、外用組成物(懸濁液)を得た。
Test example 1
1. Preparation of composition for external application (suspension) An external composition (suspension) having the composition shown in Table 1 was prepared. Specifically, first, heparin-like substances and starch acrylate 1000 were added to purified water and dissolved. Subsequently, each powder shown in Table 1 was added and mixed to obtain an external composition (suspension).
2.分散安定性の評価方法
調製後の外用組成物を室温にて5分間静置した後に、外観を観察することにより粉体の分散性安定性の評価を行った。分散安定性は、以下の基準に従って判定した。
2. Evaluation Method of Dispersion Stability After preparing the external composition after preparation for 5 minutes at room temperature, the dispersibility stability of the powder was evaluated by observing the appearance. The dispersion stability was determined according to the following criteria.
○:粉体が均一に分散している。
△:粉体が沈降し、液の一部が透明になっている。
×:全ての粉体が底部まで沈降し、粉体が沈降している部分を除く液のほぼ全部が透明になる。
○: The powder is uniformly dispersed.
(Triangle | delta): Powder settles and a part of liquid is transparent.
X: All powder settles to the bottom, and almost all of the liquid excluding the portion where the powder settles becomes transparent.
3.評価結果
得られた結果を表1に示す。また、実施例7及び比較例5の外用組成物を5分間静置した後の外観を観察した写真を図1に示す。粉体のみを含む場合には、粉体の沈降が認められ、粉体の分散安定性が悪かった(比較例1〜5)。これに対して、粉体及びアクリル酸デンプンと共にヘパリン類似物質を含む場合には、粉体が沈降することなく、粉体の分散安定性が著しく向上していた(実施例1〜7)。
3. The results obtained are shown in Table 1. Moreover, the photograph which observed the external appearance after leaving the composition for external use of Example 7 and Comparative Example 5 for 5 minutes is shown in FIG. When only powder was included, sedimentation of the powder was observed, and the dispersion stability of the powder was poor (Comparative Examples 1 to 5). On the other hand, when the heparin-like substance was contained together with the powder and starch acrylate, the dispersion stability of the powder was remarkably improved without causing the powder to settle (Examples 1 to 7).
更に、ヘパリン類似物質と共に、粉体として酸化鉄を含む実施例4及び5では、ヘパリン類似物質を含まない比較例3及び4に比べて、色調が明るくなって発色性が向上していた。即ち、本結果から、ヘパリン類似物質及び酸化鉄を含む外用組成物は、シワを目立たなくするのに特に好適であることも確認された。 Furthermore, in Examples 4 and 5 containing iron oxide as a powder together with the heparin-like substance, the color tone was brighter and the color development was improved compared to Comparative Examples 3 and 4 not containing the heparin-like substance. That is, from this result, it was also confirmed that an external composition containing a heparin-like substance and iron oxide is particularly suitable for making wrinkles inconspicuous.
試験例2
1.外用組成物(乳化組成物)の調製
表2に示す組成の外用組成物(乳化組成物)を調製した。具体的には、カルボキシビニルポリマーを適量の精製水に混合、撹拌し、水相画分1を得た。別途、表2のCの欄に示す成分を80℃で加熱溶解し、油相画分を得た。また、ヘパリン類似物質を適量の精製水に混合、撹拌し、水相画分2を得た。水相画分1に、表2のBの欄に示す粉体と水相画分2を混合した後に、油相画分を加えて、ホモミキサーにより乳化処理を行い、乳化させた。次いで、リン酸を添加することにより、pH5.0の外用組成物(クリーム状の組成物)を得た。
Test example 2
1. Preparation of composition for external use (emulsion composition) An external composition (emulsion composition) having the composition shown in Table 2 was prepared. Specifically, the carboxyvinyl polymer was mixed with an appropriate amount of purified water and stirred to obtain an aqueous phase fraction 1. Separately, the components shown in the column C of Table 2 were dissolved by heating at 80 ° C. to obtain an oil phase fraction. A heparin-like substance was mixed with an appropriate amount of purified water and stirred to obtain an aqueous phase fraction 2. The aqueous phase fraction 1 was mixed with the powder shown in the column B of Table 2 and the aqueous phase fraction 2, and then the oil phase fraction was added and emulsified by a homomixer to be emulsified. Subsequently, the external composition (cream-like composition) of pH 5.0 was obtained by adding phosphoric acid.
2.分散安定性の評価方法
調製後の外用組成物の外観を観察することにより粉体の分散性安定性の評価を行った。分散安定性は、以下の基準に従って判定した。
2. Evaluation Method of Dispersion Stability The dispersibility stability of the powder was evaluated by observing the appearance of the external composition after preparation. The dispersion stability was determined according to the following criteria.
○:粉体が均一に分散している。
×:粉体が均一に分散できておらず、ダマが生じている。
○: The powder is uniformly dispersed.
X: The powder is not uniformly dispersed, and lumps are generated.
3.評価結果
得られた結果を表2に示す。粉体と共にヘパリン類似物質を含む場合には、ダマを生じさせることなく、粉体を均一に分散できていた(実施例8〜11)。また、アクリル酸デンプン及びヘパリン類似物質と共に、粉体として酸化鉄を含む実施例11では、色調が明るくなって発色性が向上しており、シワを目立たなくするのに特に好適であることも確認された。
3. The results obtained are shown in Table 2. When the heparin-like substance was included together with the powder, the powder could be uniformly dispersed without causing lumps (Examples 8 to 11). In addition, in Example 11 containing iron oxide as a powder together with starch acrylate and heparin-like substances, it was confirmed that the color tone was bright and color development was improved, and that it was particularly suitable for making wrinkles inconspicuous. It was done.
試験例3
1.外用組成物(乳化組成物)の調製
表3に示す組成の外用組成物(乳化組成物)を調製した。具体的には、カルボキシビニルポリマーを適量の精製水に混合、撹拌し、水相画分1を得た。また、表1のDの欄に示す成分を80℃で加熱溶解し、油相画分を得た。更に、アクリル酸デンプン1000を適量の精製水に混合、撹拌し、水相画分2を得た。水相画分1に、表1のCの欄に示す粉体と水相画分2を混合した後に、油相画分を加えて、ホモミキサーにより乳化処理を行い、乳化させた。次いで、リン酸を添加することにより、pH5.0の外用組成物(クリーム状の乳化組成物)を得た。
Test example 3
1. Preparation of composition for external use (emulsion composition) An external composition (emulsion composition) having the composition shown in Table 3 was prepared. Specifically, the carboxyvinyl polymer was mixed with an appropriate amount of purified water and stirred to obtain an aqueous phase fraction 1. Moreover, the component shown in the column of D in Table 1 was heated and dissolved at 80 ° C. to obtain an oil phase fraction. Furthermore, starch acrylate 1000 was mixed with an appropriate amount of purified water and stirred to obtain aqueous phase fraction 2. The aqueous phase fraction 1 was mixed with the powder shown in the column C of Table 1 and the aqueous phase fraction 2, and then the oil phase fraction was added and emulsified by a homomixer to be emulsified. Next, phosphoric acid was added to obtain an external composition (cream emulsion composition) having a pH of 5.0.
2.分散安定性の評価方法
前記試験例2と同様の方法で、粉体の分散安定性について評価した。
2. Evaluation Method of Dispersion Stability The dispersion stability of the powder was evaluated by the same method as in Test Example 2.
3.シワの隠蔽効果の評価方法
得られた各外用組成物を用いて、シワの隠蔽効果を確認するために、粉体侵入性、肌質感、及び粉体保持性の評価を行った。具体的な評価方法は、以下に示す通りである。
3. Evaluation Method of Wrinkle Concealing Effect In order to confirm the wrinkle concealing effect, each of the obtained compositions for external use was evaluated for powder penetration, skin texture, and powder retention. A specific evaluation method is as follows.
[粉体侵入性]
手の甲のシワが気になるモニター10名に対して、外用組成物の塗布により、塗布部のシワを埋めることができるか否か評価した。具体的には、外用組成物0.3gを手の甲に塗布し、1分間馴染ませた後に、目視にて観察し、粉体によってシワを埋めることができたかを評価した。シワがきれいに埋まったと感じた人の人数をカウントし、以下の基準により粉体侵入性を判定した。
◎:8〜10人
○:5〜7人
△:2〜4人
×:0〜1人
[Powder penetration]
For 10 monitors worried about wrinkles on the back of the hand, it was evaluated whether or not the wrinkles in the application part could be filled by applying the composition for external use. Specifically, 0.3 g of the composition for external use was applied to the back of the hand and allowed to acclimatize for 1 minute, and then visually observed to evaluate whether wrinkles could be filled with powder. The number of people who felt that the wrinkles were filled up was counted, and the powder penetration was determined according to the following criteria.
◎: 8 to 10 people ○: 5 to 7 people △: 2 to 4 people ×: 0 to 1 person
[肌質感]
手の甲のシワが気になるモニター10名に対して、外用組成物の塗布により、塗布部のシワが、本来の肌部分と違和感なく視覚的に似た肌質になっているか否か評価した。具体的には、外用組成物0.3gを手の甲に塗布し、1分間馴染ませた後に、目視にて観察し、塗布部のシワが、本来の肌部分と違和感なく視覚的同じ肌質になってシワが目立ちにくくなったか評価した。シワが、本来の肌部分と違和感なく視覚的に似た肌質になってシワが目立ちにくくなったと感じた人の人数をカウントし、以下の基準により肌質感を判定した。
◎:8〜10人
○:5〜7人
△:2〜4人
×:0〜1人
[Skin texture]
For 10 monitors worried about the wrinkles on the back of the hand, the application of the composition for external use evaluated whether the wrinkles in the application part had a skin quality visually similar to that of the original skin part. Specifically, after applying 0.3 g of the composition for external application to the back of the hand and letting it fit for 1 minute, it is visually observed, and the wrinkles of the application part are visually the same skin quality without any discomfort. It was evaluated whether wrinkles became inconspicuous. The number of people who felt that the wrinkles were visually similar to the original skin and the wrinkles were less noticeable was counted, and the skin texture was judged according to the following criteria.
◎: 8 to 10 people ○: 5 to 7 people △: 2 to 4 people ×: 0 to 1 person
[粉体保持性]
手の甲にシワが気になるモニター10名に対して、塗布した外用組成物が取れにくいか否か評価した。具体的には、外用組成物0.3gを手の甲に塗布し、1分間馴染ませた後に、3回素手で撫でながら流水で洗い、外用組成物が手のシワ部分から除去され難いかを評価した。外用組成物が手のシワ部分から除去され難いと感じた人の人数をカウントし、以下の基準により粉体保持性を判定した。
○:7〜10人
△:3〜6人
×:0〜2人
[Powder retention]
It was evaluated whether or not the applied external composition was difficult to remove for 10 monitors worried about the back of the hand. Specifically, 0.3 g of the externally applied composition was applied to the back of the hand and allowed to acclimate for 1 minute, and then washed with running water while being boiled 3 times with bare hands to evaluate whether the externally applied composition was difficult to be removed from the wrinkled part of the hand. . The number of people who felt that the composition for external use was difficult to be removed from the wrinkled part of the hand was counted, and the powder retention was determined according to the following criteria.
○: 7 to 10 people Δ: 3 to 6 people ×: 0 to 2 people
4.評価結果
得られた結果を表3に示す。前記試験例2の結果と同様に、粉体とヘパリン類似物質を含む場合には、ダマを生じさせることなく、粉体を均一に分散できていた(実施例12〜24)。
4). The results obtained are shown in Table 3. Similar to the results of Test Example 2, when the powder and the heparin-like substance were included, the powder could be uniformly dispersed without causing lumps (Examples 12 to 24).
また、粉体単独の場合には、粉体侵入性は良好であったものの、肌質感及び粉体保持性の点で不十分であった(比較例7)。これに対して、粉体とアクリル酸デンプンを併用した場合には、粉体侵入性、肌質感、及び粉体保持性が良好であり、優れたシワ隠蔽効果を有していた(実施例12〜24)。また、平均粒子径0.6〜16μmのいずれの粉体でも、アクリル酸デンプンとの併用によって、粉体侵入性、肌質感、及び粉体保持性が良好になることも確認された。また、実施例15と実施例24との対比から明らかなように、アクリル酸デンプンは、肌質感、及び粉体保持性の向上に寄与するだけでなく、粉体侵入性を向上させる作用を有していることも確認された。 Further, in the case of the powder alone, although the powder penetration was good, it was insufficient in terms of skin texture and powder retention (Comparative Example 7). On the other hand, when powder and starch acrylate were used in combination, powder penetration, skin texture, and powder retention were good and had an excellent wrinkle hiding effect (Example 12). To 24). It was also confirmed that any powder having an average particle size of 0.6 to 16 μm improved powder penetration, skin texture, and powder retention when used in combination with starch acrylate. Further, as is clear from the comparison between Example 15 and Example 24, starch acrylate not only contributes to the improvement of skin texture and powder retention, but also has the effect of improving powder penetration. It was also confirmed that.
実施例13と14を対比すると、実施例14の方が肌質感がよいと感じた人が多く、また、肌質感の評価結果が○になった実施例の中では、実施例22及び23が、シワが目立ちにくくなったと感じた人の人数が最多の7人であった。この結果から、粉体として、屈折率が2.2〜2.8程度の粉体(酸化チタン)と屈折率が1.3〜2.0程度の粉体(二酸化ケイ素)を併用することにより、より一層優れた肌質感を表出できることが明らかとなった。
In contrast to Examples 13 and 14, there are many people who feel that the skin texture is better in Example 14, and among the examples in which the evaluation result of the skin texture is ○, Examples 22 and 23 are The number of people who felt wrinkles were inconspicuous was seven, the largest. From this result, by using a powder (titanium oxide) having a refractive index of about 2.2 to 2.8 and a powder (silicon dioxide) having a refractive index of about 1.3 to 2.0 as a powder, It was revealed that an even better skin texture can be expressed.
処方例
表4〜6に示す組成の外用組成物(乳化組成物)を調製した。具体的には、カルボキシビニルポリマーを適量の精製水に混合、撹拌し、水相画分1を得た。別途、表4〜6のCの欄に示す成分を80℃で加熱溶解し、油相画分を得た。更に、表4〜6のAの欄に示す成分を適量の精製水に混合、撹拌し、水相画分2を得た。水相画分1に、表4〜6のBの欄に示す粉体と水相画分2を混合した後に、油相画分を加えて、ホモミキサーにより乳化処理を行い、乳化させた。次いで、リン酸を添加することにより、pH5.0の外用組成物(クリーム状の乳化組成物)を得た。得られた外用組成物について、前記試験例2と同様の方法で粉体の分散安定性の評価を行ったところ、いずれも、粉体の均一な分散が確認された。また、前記試験例3と同様の方法でシワ隠蔽効果の評価を行ったところ、いずれの外用組成物でも、粉体侵入性、肌質感、及び粉体保持性が良好であり、優れたシワ隠蔽効果を有していた。
Formulation Example External compositions (emulsified compositions) having the compositions shown in Tables 4 to 6 were prepared. Specifically, the carboxyvinyl polymer was mixed with an appropriate amount of purified water and stirred to obtain an aqueous phase fraction 1. Separately, the components shown in the column C of Tables 4 to 6 were heated and dissolved at 80 ° C. to obtain an oil phase fraction. Furthermore, the components shown in the column A of Tables 4 to 6 were mixed with an appropriate amount of purified water and stirred to obtain an aqueous phase fraction 2. The water phase fraction 1 was mixed with the powder shown in the column B of Tables 4 to 6 and the aqueous phase fraction 2, and then the oil phase fraction was added and emulsified by a homomixer to be emulsified. Next, phosphoric acid was added to obtain an external composition (cream emulsion composition) having a pH of 5.0. When the dispersion stability of the powder was evaluated for the obtained external composition by the same method as in Test Example 2, uniform dispersion of the powder was confirmed in all cases. Moreover, when the wrinkle hiding effect was evaluated by the same method as in Test Example 3, any of the compositions for external use had good powder penetration, skin texture, and powder retention, and excellent wrinkle hiding. Had an effect.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019119690A (en) * | 2017-12-28 | 2019-07-22 | 花王株式会社 | Oil-in-water emulsion composition |
JP2019202961A (en) * | 2018-05-24 | 2019-11-28 | ポーラ化成工業株式会社 | Polymer and metal oxide powder-containing external composition |
JP2022089969A (en) * | 2017-12-28 | 2022-06-16 | 花王株式会社 | Oil-in-water emulsion composition |
JP2022117500A (en) * | 2021-01-29 | 2022-08-10 | 株式会社東洋新薬 | External preparation for skin |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10506121A (en) * | 1994-09-27 | 1998-06-16 | ニコムド イメージング エイ/エス | Contrast agent |
JP2000204014A (en) * | 1999-01-11 | 2000-07-25 | Pola Chem Ind Inc | Cosmetic for sensitive skin |
JP2000204020A (en) * | 1999-01-13 | 2000-07-25 | Pola Chem Ind Inc | Cosmetic for lip |
JP2001199839A (en) * | 2000-01-18 | 2001-07-24 | Pola Chem Ind Inc | Functionally gradient powder and composition containing the same |
JP2002020294A (en) * | 2000-06-30 | 2002-01-23 | Lion Corp | Skin care preparation |
JP2003277217A (en) * | 2002-03-25 | 2003-10-02 | Kose Corp | Cosmetic |
JP2006273806A (en) * | 2005-03-30 | 2006-10-12 | Kose Corp | Cosmetic for eyelash |
JP2009173573A (en) * | 2008-01-24 | 2009-08-06 | Shiseido Co Ltd | Cosmetic |
JP2013103885A (en) * | 2011-11-10 | 2013-05-30 | Kose Corp | Unevenness-correcting cosmetic |
JP2014101344A (en) * | 2012-11-16 | 2014-06-05 | Daito Kasei Kogyo Kk | Cosmetic |
-
2016
- 2016-03-30 JP JP2016069071A patent/JP6879670B2/en active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10506121A (en) * | 1994-09-27 | 1998-06-16 | ニコムド イメージング エイ/エス | Contrast agent |
JP2000204014A (en) * | 1999-01-11 | 2000-07-25 | Pola Chem Ind Inc | Cosmetic for sensitive skin |
JP2000204020A (en) * | 1999-01-13 | 2000-07-25 | Pola Chem Ind Inc | Cosmetic for lip |
JP2001199839A (en) * | 2000-01-18 | 2001-07-24 | Pola Chem Ind Inc | Functionally gradient powder and composition containing the same |
JP2002020294A (en) * | 2000-06-30 | 2002-01-23 | Lion Corp | Skin care preparation |
JP2003277217A (en) * | 2002-03-25 | 2003-10-02 | Kose Corp | Cosmetic |
JP2006273806A (en) * | 2005-03-30 | 2006-10-12 | Kose Corp | Cosmetic for eyelash |
JP2009173573A (en) * | 2008-01-24 | 2009-08-06 | Shiseido Co Ltd | Cosmetic |
JP2013103885A (en) * | 2011-11-10 | 2013-05-30 | Kose Corp | Unevenness-correcting cosmetic |
JP2014101344A (en) * | 2012-11-16 | 2014-06-05 | Daito Kasei Kogyo Kk | Cosmetic |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019119690A (en) * | 2017-12-28 | 2019-07-22 | 花王株式会社 | Oil-in-water emulsion composition |
JP7063616B2 (en) | 2017-12-28 | 2022-05-09 | 花王株式会社 | Oil-in-water emulsification composition |
JP2022089969A (en) * | 2017-12-28 | 2022-06-16 | 花王株式会社 | Oil-in-water emulsion composition |
JP7288535B2 (en) | 2017-12-28 | 2023-06-07 | 花王株式会社 | Oil-in-water emulsion composition |
JP2019202961A (en) * | 2018-05-24 | 2019-11-28 | ポーラ化成工業株式会社 | Polymer and metal oxide powder-containing external composition |
JP7157554B2 (en) | 2018-05-24 | 2022-10-20 | ポーラ化成工業株式会社 | External composition containing polymer and metal oxide powder |
JP2022117500A (en) * | 2021-01-29 | 2022-08-10 | 株式会社東洋新薬 | External preparation for skin |
JP7485386B2 (en) | 2021-01-29 | 2024-05-16 | 株式会社東洋新薬 | Skin preparations |
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