JP2022117500A - External preparation for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external preparation for skin having a high moisturizing effect, a wrinkle-hiding effect, and excellent feeling of use.

SOLUTION: Provided is an external preparation for skin comprising: (a) a heparinoid; (b) an ultraviolet scattering agent; and (c) a powder having an average particle size of 1 to 100 μm.

SELECTED DRAWING: None

COPYRIGHT: (C)2022,JPO&INPIT

Description

TECHNICAL FIELD The present invention relates to an external preparation for skin containing a heparinoid. In particular, the present invention relates to an oil-in-water emulsified external preparation for skin containing a heparinoid.

In recent years, various external preparations using heparinoids have been proposed. Heparin-like substances are widely used as active ingredients of external preparations because they have excellent moisturizing action, anti-inflammatory action, blood circulation promoting action, and the like (Patent Document 1). However, cosmetics containing a heparin-like substance have problems such as poor compatibility with the skin and difficulty in obtaining a feeling of penetration and a feeling of moisturizing. In addition, due to its high efficacy, heparin analogues are desired to be applied not only to basic cosmetics such as various creams and lotions, but also to various cosmetics, but their development has not been sufficient.

Japanese Patent Publication No. 62-004362

Accordingly, the present inventors conducted various studies with the object of enhancing the effect of a heparinoid and providing an external preparation for skin with an excellent feeling of use.

As a result, the present inventors succeeded in developing an external preparation for skin that achieves both moisturizing properties and a feeling of use by blending an ultraviolet scattering agent and a specific powder together with a heparin analogous substance, and completed the present invention. Arrived.

That is, the present invention is as follows.
<1> An external preparation for skin characterized by containing the following (a) to (c).
(a) a heparin-like substance (b) an ultraviolet scattering agent (c) a powder having an average particle size of 1 to 100 μm <2> and (d) an oil agent <1> .
<3> The external preparation for skin according to any one of <1> or <2>, which is an oil-in-water emulsion.
<4> The external preparation for skin according to any one of <1> to <3>, which has a viscosity of 3,000 mPa·s or more.
<5>(b) The external preparation for skin according to any one of <1> to <4>, wherein the ultraviolet scattering agent has an average particle size of 5 to 500 nm.
<6> The skin according to any one of <1> to <5>, wherein the content of (a) the heparin analogue in the composition is 0.0001% by mass or more and 0.5% by mass or less. External agent.
<7> The external preparation for skin according to any one of <1> to <6>, which is for sunscreen.

According to the present invention, by containing a heparin-like substance, an ultraviolet scattering agent, and a specific powder, it is possible to obtain an external preparation for skin that has a high moisturizing effect, a wrinkle-hiding effect, and an excellent feel when used.

The external preparation for skin of the present invention will be described in detail below. In addition, the present invention is not limited to the embodiments shown below, and can be changed within the scope of those skilled in the art, such as other embodiments, additions, modifications, deletions, etc. is also included in the scope of the present invention as long as the functions and effects of the present invention are exhibited.

<(a) heparinoid>
The external preparation for skin of the present invention is characterized by containing a heparinoid. Heparin-like substances are polysulfated mucopolysaccharides such as chondroitin polysulfate, which are obtained by polysulfating polysaccharides having repeating units of disaccharides consisting of D-glucuronic acid and N-acetyl-D-galactosamine, and have a moisturizing effect. , anti-inflammatory effect, blood circulation promoting effect and the like.

The content of (a) the heparin analogue in the external preparation for skin of the present invention is not particularly limited, and is preferably 0.00001% by mass or more, more preferably 0.00005% by mass or more. It is particularly preferably 0.0001% by mass or more from the viewpoint of obtaining an external preparation for skin with an effect and an excellent feeling in use. It is preferably 5% by mass or less, more preferably 1% by mass or less, and particularly preferably 0.5% by mass or less from the viewpoint of obtaining an external preparation for skin with high moisturizing effect, wrinkle-hiding effect, and excellent feeling of use.

<(b) UV scattering agent>
The external preparation for skin of the present invention contains an ultraviolet scattering agent. The ultraviolet scattering agent that can be used in the present invention is not particularly limited as long as it is usually used for external skin preparations, but inorganic compounds are preferable, and metal oxides are more preferable, because they are highly effective in scattering ultraviolet rays. Specifically, one or more selected from titanium oxide, zinc oxide, iron oxide, zirconium oxide, and cerium oxide can be used. Among these, titanium oxide and zinc oxide are preferred.

Moreover, the ultraviolet scattering agent used in the present invention is preferably subjected to hydrophobizing treatment. By making the surface hydrophobic, it is possible to improve dispersibility in oil and water resistance. The hydrophobization treatment of the UV scattering agent may be performed using a known surface treatment agent that is hydrophobized, for example, silicone treatment such as methylhydrogenpolysiloxane and methylpolysiloxane; alkylsilane treatment; Fluorine treatment with acid ester, perfluoroalcohol, etc.; amino acid treatment with N-acylglutamic acid, etc.; lecithin treatment; metal soap treatment; fatty acid treatment;

The UV scattering agent used in the present invention preferably has an average particle size of 1 to 1000 nm, more preferably 5 to 500 nm, so that an external preparation for skin with a high moisturizing effect, a wrinkle-hiding effect, and an excellent feeling of use can be obtained. From the point of view, 10 to 300 nm is particularly preferable. The average particle size of the ultraviolet scattering agent used in the present invention is measured by a dynamic light scattering method.

The content of the (b) ultraviolet scattering agent in the external preparation for skin of the present invention is not particularly limited, and is preferably 1% by mass or more, more preferably 3% by mass or more. It is particularly preferably 5% by mass or more from the viewpoint of obtaining an external preparation for skin with a pleasant feeling. The content is preferably 50% by mass or less, more preferably 40% by mass or less, and particularly preferably 30% by mass or less from the viewpoint of obtaining a skin preparation for external use with high moisturizing effect, wrinkle-hiding effect, and excellent feeling of use. .

<(c) Powder having an average particle size of 1 to 100 μm>
The external preparation for skin of the present invention contains powder having an average particle size of 1 to 100 μm.

Examples of powders that can be used in the present invention include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, and calcium carbonate. , aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, Smectite, clay, mud, metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine blue, Prussian blue, carbon black, titanium oxide, zinc oxide, Alumina, silica, fumed silica (ultrafine silicic anhydride), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine phlogopite, fine particle composite powder, inorganic powder such as gold and aluminum, and these Inorganic powders such as powders made hydrophobic or hydrophilic by treating them with silicones such as hydrogen silicones, cyclic hydrogen silicones, other silanes, or various surface treatment agents such as titanium coupling agents; starch, cellulose, Nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate/polymethyl methacrylate laminate powder, polyethylene terephthalate/aluminum/epoxy laminate powder , organic powders such as urethane powders, silicone powders, Teflon (registered trademark) powders, surface-treated powders, and organic-inorganic composite powders.

The average particle size of the powder used in the topical skin preparation of the present invention is 1 to 100 μm, preferably 1 to 50 μm, from the viewpoint of obtaining a topical skin preparation with high moisturizing effect, wrinkle-hiding effect, and excellent feeling of use. Therefore, 1 to 30 μm is particularly preferable. The average particle size of powder in the present invention is measured by a laser diffraction/scattering method.

The content of (c) the powder having an average particle size of 1 to 100 μm in the external preparation for skin of the present invention is not particularly limited, and is preferably 0.01% by mass or more, more preferably 0.05% by mass or more. , the content is particularly preferably 0.1% by mass or more from the viewpoint of obtaining a skin preparation for external use with a high moisturizing effect, a wrinkle-hiding effect, and an excellent feeling of use. In addition, it is preferably 20% by mass or less, more preferably 15% by mass or less, and particularly preferably 10% by mass or less from the viewpoint of obtaining an external preparation for skin with high moisturizing effect, wrinkle-hiding effect, and excellent feeling of use.

<(d) oil>
The external preparation for skin of the present invention preferably contains an oil agent. The oil agent that can be used in the present invention is not particularly limited as long as it is usually used for external skin preparations, but oil agents that are liquid at 25° C. are preferred, and non-volatile oil agents are particularly preferred. Specifically, for example, hydrocarbon oils such as liquid paraffin, squalane and squalene; fatty acids such as isostearic acid, oleic acid and polyhydroxystearic acid; higher alcohols such as octyldodecanol and tetradecyldecanol; isopropyl acid, isopropyl myristate, isopropyl stearate, isobutyl stearate, 2-ethylhexyl stearate, isopropyl isostearate, butyl isostearate, decyl isostearate, lauryl isostearate, isodecyl isodecanoate, isodecyl isononanoate, isotridecyl isononanoate, isononane isononyl acid, diisostearyl malate, neopentyl glycol dioctoate, propylene glycol dicaprate, propylene glycol dicaprylate, glyceryl tri-2-ethylhexanoate, polyglyceryl monoisostearate, polyglyceryl diisostearate, triisostearin Diglyceryl acid, diglyceryl tetraisostearate, diethyl sebacate, cetyl 2-ethylhexanoate, ethylhexyl palmitate, octyldodecyl myristate, oleyl oleate, ethyl oleate, di(phytosteryl/2-octyl N-lauroyl-glutamate) dodecyl), N-lauroyl-glutamic acid di(phytosteryl/behenyl/2-octyldodecyl), N-lauroyl-glutamic acid di(cholesteryl/2-octyldodecyl), N-lauroyl-sarcosine-isopropyl ester oils; silicone oils such as siloxane, cyclopentasiloxane, and alkoxy-modified polysiloxane; and the like, and one or more of these can be used.

When the external skin preparation of the present invention is blended with (d) an oil agent, the content is not particularly limited, but is preferably 1% by mass or more, more preferably 3% by mass or more. From the viewpoint of obtaining an external preparation for skin with an excellent feeling in use, the content is particularly preferably 5% by mass or more. The content is preferably 50% by mass or less, more preferably 40% by mass or less, and particularly preferably 30% by mass or less from the viewpoint of obtaining a skin preparation for external use with high moisturizing effect, wrinkle-hiding effect, and excellent feeling of use. .

<Other ingredients>
In addition to the above ingredients, the external skin preparation of the present invention may optionally contain other ingredients. Other ingredients include water, thickener, gelling agent, moisturizer, dispersant, plasticizer, spreading agent, preservative, fragrance, anionic surfactant, amphoteric surfactant, and nonionic surfactant. Surfactants such as surfactants, film-forming agents, pH adjusters, deodorants, chelating agents, antioxidants, antibacterial agents, antibacterial and antifungal agents, anti-inflammatory agents, active ingredients such as whitening agents, animal extracts, plant extracts One or more kinds of ingredients that are usually used in external skin preparations, such as cosmetic ingredients and medicinal ingredients such as

<External preparation for skin>
The external preparation for skin of the present invention is a composition that is applied to the skin for use. The external preparation for skin of the present invention is preferably an emulsion, and particularly preferably an oil-in-water emulsion. By making it an oil-in-water emulsion, it is possible to achieve both a high moisturizing effect and a wrinkle-hiding effect when applied to the skin and a good feeling of use. The external preparation for skin of the present invention preferably has a high viscosity, preferably 3,000 mPa·s or more, more preferably 3,500 mPa·s or more, and particularly preferably 4,000 mPa·s or more. Also, it is preferably 500,000 mPa·s or less, more preferably 300,000 mPa·s or less, and particularly preferably 200,000 mPa·s or less.

Moreover, the external preparation for skin of the present invention is preferably an emulsion. The emulsified form may be any of oil-in-water type, water-in-oil type, water-in-oil-in-water type, and oil-in-water-in-oil type. is preferably an emulsion of

The external preparation for skin of the present invention can be used for pharmaceuticals, quasi-drugs, and cosmetics. For example, pharmaceuticals such as external skin preparations containing drugs; quasi-drugs such as medicated cosmetics; skin care cosmetics such as gel lotions, milky lotions, creams, serums, sunscreens, and daytime moisturizers; foundations and makeup bases , It can be used for various forms of products such as make-up cosmetics. Among these, the external preparation for skin of the present invention is preferably a sunscreen or a makeup base, and particularly preferably a sunscreen.

The external preparation for skin of the present invention can be produced according to a conventional method. That is, at a predetermined temperature of about 25°C, the aqueous phase component and the oil phase component are separately prepared, heated to 80°C for emulsification, and then cooled to about room temperature with stirring to obtain the composition of the present invention. A skin external preparation can be obtained.

EXAMPLES The present invention will be described below based on examples.

<Evaluation of topical skin preparation>
According to the composition shown in Table 1 below, topical skin preparations (Examples 1 to 8, Comparative Examples 1 and 2), which are oil-in-water emulsions, were produced. Specifically, 1,3-butylene glycol, (a), and phenoxyethanol are added to water and mixed to prepare an aqueous phase component, (d) oil agent (b), (c), and acrylic acid. Sodium/sodium acryloyldimethyl taurate copolymer was added and mixed, and the prepared oil phase component was heated to 80° C. for emulsification, and then cooled to about room temperature while stirring. The obtained external preparation for skin was evaluated for the following items. Table 1 shows the results.
Viscosity measurement
The viscosity of the obtained external preparation for skin was measured using a viscometer (RVT model manufactured by Brookfield).
Evaluation of usability
Five subjects in their twenties to thirties were randomly selected as subjects. Using the above external preparation for skin on the subject's face, the feeling of use (spreadability at the time of application, smoothness, non-stickiness after application, non-squeaky feeling, moderate moist feeling) was comprehensively judged as an evaluation item, A questionnaire was conducted based on five-level evaluation criteria. The average value of the questionnaire was calculated and evaluated.
・5: very good ・4: good ・3: neither ・2: bad ・1: very bad
Evaluation of wrinkle hiding effect
Five subjects in their twenties to thirties were randomly selected as subjects. After using the external preparation for skin on the face of the subject, a questionnaire was conducted based on five-level evaluation criteria to determine to what extent wrinkles were less noticeable than before use. The average value of the questionnaire was calculated and evaluated.
・ 5: Very good (wrinkles are less noticeable than before use)
・ 4: Good ・ 3: No change before and after use ・ 2: Bad ・ 1: Very bad (wrinkles are more noticeable than before use)
Evaluation of stratum corneum moisture content
Five subjects in their twenties to thirties were randomly selected as subjects. The water content of the stratum corneum was measured by the following method for a 4 cm x 4 cm portion of the inside of the forearm where the topical skin preparation was to be applied, using a skin surface stratum corneum moisture measuring device SKICON-200EX (manufactured by IBS Co., Ltd.). It was measured. This skin surface stratum corneum water content measuring device evaluates skin conductance (electrical conductivity, unit: μS) as the water content of the stratum corneum. Next, the skin preparation for external use was applied to the measurement site, and the water content of the stratum corneum was measured when the skin preparation for external use was used.

As shown in Table 1, Examples 1 to 8, which are the compositions of the present invention, exhibited high viscosity values of 4,800 mPa·s or more. As is clear from Table 1, the external preparations for skin of Examples 1 to 8 have a high moisturizing effect due to their high water content in the stratum corneum when used, and are excellent in wrinkle-hiding effects. It can be seen that the feeling of use is good, such as good quality, no stickiness after application, no squeakiness, and moderate moist feeling. On the other hand, the external preparation for skin of Comparative Example 1 has a low wrinkle-hiding effect and a poor feeling when used, and the external skin preparation of Comparative Example 2 has a low wrinkle-hiding effect and a poor feeling of use. The water content of the stratum corneum is also low, indicating that the moisturizing effect is low. From the above results, it is clear that the external preparation for skin of the present invention has a high moisturizing effect, a wrinkle-hiding effect, and excellent usability.

<Production Examples 1 to 10>
An oil-in-water emulsion for external use for skin was produced in the same manner as in Example 1 according to the composition shown in Table 2 below. The external preparations for skin obtained in the following production examples have a viscosity of 3,000 mPa·s or more, and are excellent in moisturizing effect, wrinkle-hiding effect, and feeling of use.

The external preparation for skin of the present invention contains a heparin-like substance, an ultraviolet scattering agent, and a specific powder, so that it is possible to provide an external preparation for skin that has a high moisturizing effect, a wrinkle-hiding effect, and an excellent feeling when used. It has a high possibility of industrial application.

Claims (3)

An external preparation for skin characterized by containing the following (a) to (d).
(a) a heparin-like substance (b) an ultraviolet scattering agent (c) at least one powder selected from silica or pigment grade titanium oxide (d) at least one selected from ethylhexyl palmitate, isostearic acid and polyhydroxystearic acid More than seed oil 2. The external preparation for skin according to claim 1, which is an oil-in-water emulsion. 3. The external preparation for skin according to claim 1, wherein the viscosity is 3,000 mPa.s or more.