JP2020132631A - External skin composition - Google Patents

Abstract

To provide an external skin composition excellent in easy taking-out in use, spreadability during application and skin compatibility by increasing a value of angular frequency of the sol-gel transition point in dynamic viscoelasticity even if a hydrophobic modified polyether urethane is contained.SOLUTION: There is provided an external skin composition which comprises (A) a hydrophobic modified polyether urethane and (B) one or two or more components selected from the group consisting of nicotinic acid amide, a vitamin C derivative, arbutin and tranexamic acids.SELECTED DRAWING: None

Description

The present invention relates to a composition for external use on the skin. More specifically, it relates to a composition containing a hydrophobically modified polyether urethane and one or more components selected from the group consisting of nicotinamide, vitamin C derivatives, arbutin, and tranexamic acids.

In the present invention, the hydrophobically modified polyether urethane (HEUR) is a kind of water-soluble thickener, and has a property that the gel is restored even if the gel once formed is broken. It also has a unique thixotropy property. Therefore, for example, in Patent Document 1, a hydrophobically modified polyether urethane is used for producing a gel-like oil-in-water emulsified cosmetic that is stable at a high temperature and has a peculiar elasticity.

Japanese Unexamined Patent Publication No. 2016-08868

Due to the high resilience of the hydrophobically modified polyether urethane gel as described above, when used in a liquid or paste-like external composition for skin, the composition retains its original shape even when force is applied with a finger or the like. Try to maintain. Therefore, when an attempt is made to scoop a composition containing a hydrophobically modified polyether urethane with a finger or the like, there is a problem that the composition remains in a lump and easily spills from the finger, making it difficult to remove. There are problems that the composition does not spread well and is difficult to apply, and that it does not fit well on the skin.

One of the factors that cause such a problem in the hydrophobically modified polyether urethane is that G'= G in the angular frequency dependence measurement of the storage elastic modulus (G') and the loss elastic modulus (G ″) in the dynamic viscoelasticity measurement. The angular frequency value of the sol-gel transition point, which is ″, is generally small in the composition for external skin containing hydrophobic modified polyether urethane, and as a result, the formulation such as scooping or application with a finger or the like is deformed. It was considered that the composition was not able to exhibit sufficient viscosity during the operation.

Therefore, in the present invention, even if the hydrophobically modified polyether urethane is contained, the value of the angular frequency of the sol-gel transition point in the dynamic viscoelasticity is large, and the composition is easy to scoop, stretches at the time of application, and fits well on the skin. An object of the present invention is to provide an excellent external composition for skin.

As a result of diligent studies, the present inventors have made one or more components selected from the group consisting of (A) hydrophobically modified polyether urethane and (B) nicotinamide, vitamin C derivative, arbutin and tranexamic acids. It has been found that the inclusion of, increases the value of the angular frequency of the sol-gel transition point in the dynamic viscoelasticity of the skin-containing composition, and has completed the present invention.

That is, the present invention provides the following external composition for skin.
Item 1.
A composition for external use on the skin containing one or more components selected from the group consisting of (A) hydrophobically modified polyether urethane and (B) nicotinamide, vitamin C derivative, arbutin and tranexamic acid.
Item 2.
Item 2. The external composition for skin according to Item 1, wherein the component (A) is a hydrophobically modified polyether urethane represented by the following chemical formula (I):
R ¹ -{(OR ² ) _k- OCONH-R ³ [-NHCOO- (R ^4- O) _n- R ⁵ ] _h } _m (I)
(In the formula, R ¹ represents a hydrocarbon group, R ² and R ⁴ each independently represent an alkylene group having 2 to 4 carbon atoms, and R ³ may have a urethane bond, such as a straight chain, a branched chain or a branched chain. Represents a hydrocarbon group containing an aliphatic or aromatic ring, R ⁵ represents a hydrocarbon group having a branched chain; m is an integer of 2 or more, h is an integer of 1 or more, and k and n are respectively. It is an integer in the range of 0 to 1000 independently, and k + n ≧ 1).
Item 3.
Item 2. The external composition for skin according to Item 1 or 2, further comprising (C) one or more components selected from the group consisting of phenoxyethanol, dipropylene glycol and amphipathic components.
Item 4.
The amphoteric component of the component (C) is a 2-methacryloyloxyethyl phosphorylcholine-containing polymer, a divalent carboxylic acid ester, an alkanediol having 5 to 10 carbon atoms, and an alkylene oxide derivative represented by the following chemical formula (II). Item 2. The composition for external use on the skin according to any one of Items 1 to 3, which is one kind or two or more kinds selected from the group consisting of:
Z- [O- (AO) _a (EO) _b- (BO) _c- H] _n (II)
(N in the formula is an integer from 1 to 9;
Z is a group obtained by removing n hydroxy groups from a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms;
AO is an oxyalkylene group having 3-4 carbon atoms;
EO is an oxyethylene group;
BO is an oxyalkylene group having 4 carbon atoms;
a, b, and c are the average number of moles of AO, EO, and BO, respectively, which are 0 to 200 independently; a, b, and c are not all 0;
AO and EO may be added randomly or in blocks;
When n is 2 or more, the plurality of a, b, and c may be the same or different.
If Z is a hydrogen atom, n is 1).

According to the present invention, it contains a hydrophobically modified polyether urethane that increases the angular frequency value of the sol-gel transition point in dynamic viscoelasticity, is easy to scoop during use, stretches during application, and has excellent skin compatibility. A composition for external use on the skin is obtained.

In the present specification, the unit of content "mass%" is synonymous with "g / 100g".

The external composition for skin of the present invention comprises (A) a hydrophobically modified polyether urethane, and (B) one or more components selected from the group consisting of nicotinamide, vitamin C derivatives, arbutin and tranexamic acids. contains.

[(A) component]
The hydrophobically modified polyether urethane contained in the external composition for skin as the component (A) of the present invention is a polymer having a urethane bond modified by a hydrophobic group, and is used for thickening and gelling of an aqueous composition. Be done.

The hydrophobically modified polyether urethane used in the present invention is preferably represented by the following chemical formula (I).
R ¹ -{(OR ² ) _k- OCONH-R ³ [-NHCOO- (R ^4- O) _n- R ⁵ ] _h } _m (I)
(In the formula, R ¹ represents a hydrocarbon group, R ² and R ⁴ each independently represent an alkylene group having 2 to 4 carbon atoms, and R ³ may have a urethane bond, such as a straight chain, a branched chain or a branched chain. Represents a hydrocarbon group containing an aliphatic or aromatic ring, R ⁵ represents a hydrocarbon group having a branched chain; m is an integer of 2 or more, h is an integer of 1 or more, and k and n are respectively. It is an integer in the range of 0 to 1000 independently, and k + n ≧ 1).

The hydrocarbon group of R ¹ is preferably an alkyl group or an alkylene group having 2 to 12 carbon atoms, and more preferably an alkyl group or an alkylene group having 2 to 4 carbon atoms from the viewpoint of significantly exerting the effect of the present invention. Yes, more preferably an ethyl group having 2 carbon atoms.

R ² and R ⁴ each independently represent an alkylene group having 2 to 4 carbon atoms, and are preferably an alkylene group having 2 carbon atoms (ethylene group) from the viewpoint of significantly exerting the effect of the present invention.

R ³ is an h + 1 valent hydrocarbon group containing a straight chain, a branched chain, or an aliphatic ring or an aromatic ring, which may have a urethane bond. Above all, a linear hydrocarbon group is preferable from the viewpoint of remarkably exerting the effect of the present invention.

The number of carbon atoms in R ^3, from the viewpoint of achieve remarkable effects of the present invention, preferably 1 to 10, more preferably 2 to 8.
The hydrocarbon group of R ³ is preferably a hexamethylene group.

R ⁵ is a hydrocarbon group having a branched chain, and the number of carbon atoms is not particularly limited, but from the viewpoint of significantly exerting the effect of the present invention, it is preferably 8 to 36, more preferably 10 to 30, still more preferably 12. ~ 24.
The hydrocarbon groups of R ^5, preferably, include 2-dodecyl-dodecyl group.

The value of m is an integer of 2 or more, preferably 2.

The value of h is 1 or more, preferably 1 from the viewpoint of significantly exerting the effect of the present invention.

The number of repetitions of O-R ₂ k and the number of repetitions of R _4- O are 0 to 1000, respectively, and both k and n cannot be 0. That is, k + n is 1 or more.

The value of k is preferably 1 to 500, more preferably 10 to 400, still more preferably 50 to 300, and even more preferably 100 to 300, from the viewpoint of significantly exerting the effect of the present invention.

The value of n is preferably 1 to 200, more preferably 5 to 200, and further preferably 10 to 100 from the viewpoint of significantly exerting the effect of the present invention.

The hydrophobically modified polyether urethane used in the present invention is preferably a (PEG-240 / decyltetradeceth-20 / HDI) copolymer (Adecanol GT-700, Adecanol GT-730) from the viewpoint of remarkably exhibiting the effects of the present invention. : One or more selected from the group consisting of ADEKA Corporation) and Stairless-100 / PEG-136 / HDI copolymer (RHEOLUXXE 811: Elementis Japan Co., Ltd.), more preferably ( It is a PEG-240 / decyltetradeceth-20 / HDI) copolymer.

The total content of the component (A) is not particularly limited and is appropriately set according to the type of water-soluble polysaccharide, the type of other compounding components, etc., but from the viewpoint of significantly exerting the effect of the present invention, the skin. It is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, still more preferably 0.5% by mass or more, still more preferably 1% by mass or more, based on the total amount of the external composition.
The total content of the component (A) is preferably 6% by mass or less, more preferably 5% by mass or less, still more preferably 4.5% by mass or less, still more preferably 4 with respect to the total amount of the external composition for skin. It is mass% or less.
The total content of the component (A) is preferably 0.1 to 6% by mass, more preferably 0.2 to 5% by mass, still more preferably 0.5 to 4.5, based on the total amount of the external composition for skin. It is by mass, and even more preferably 1 to 4% by mass.

[(B) component]
As the component (B) of the external composition for skin of the present invention, one or more components selected from the group consisting of nicotinamide, vitamin C derivatives, arbutin and tranexamic acids are used. Among them, the external composition for skin of the present invention more preferably contains one or more selected from the group consisting of nicotinamide, vitamin C derivatives, and tranexamic acids, and more preferably, from nicotinamide and vitamin C derivatives. One or more selected from the above group is more preferable, and nicotinamide is even more preferable.

As used herein, a salt is a pharmaceutically acceptable salt. For example, but not limited to, salts with organic bases (eg, salts with tertiary amines such as trimethylamine salt, triethylamine salt, monoethanolamine salt, triethanolamine salt, pyridine salt, basic ammonium salts such as arginine). , Etc.), salts with inorganic bases (eg, alkali metal salts such as ammonium salt, sodium salt, potassium salt, alkaline earth metal salts such as calcium salt, magnesium salt, zinc salt, aluminum salt, etc.), with inorganic acids Examples thereof include salts (salts, sulfates, nitrates, hydrobromates, phosphates, etc.), salts with organic acids (acetates, butyrates, fumarates, maleates, etc.) and the like. Of these, preferred salts are triethanolamine salts, sodium salts, potassium salts, magnesium salts, or zinc salts, and more preferred salts are sodium salts, potassium salts, or magnesium salts.

Nicotinamide is an amide compound of nicotinic acid (vitamin B3 / niacin) and is a water-soluble vitamin. The nicotinamide may be an extract from a natural product or a product synthesized by a known method. Specifically, the ones listed in the 17th revised Japanese Pharmacopoeia can be used. In addition to blood circulation promoting action and rough skin improving action, melanin production inhibitory action and whitening effect are known.

The vitamin C derivative is a compound obtained by substituting a part of ascorbic acid with another atom or a substituent, a stereoisomer of ascorbic acid, or a salt thereof. Examples of the vitamin C derivative include dehydroascorbic acid; ascorbic acid alkyl esters such as 3-O-ethylascorbic acid (VC ethyl), 2-O-ethylascorbic acid, and 3-O-cetyl ascorbic acid; tetraisopalmic acid. Ascorvir (ascorvir tetra2-hexyldecanoate), ascorvir palmitate, ascorvir dipalmitate, ascorvir stearate, diolate L-ascorbic acid, tristearate L-ascorbic acid, tripalmitate ascorbic acid, triolate ascorbic acid and the like Ascorbic acid; ascorbic acid glycerin ester such as glyceryl ascorbic acid, bisglyceryl ascorbic acid, alkyl glyceryl ascorbic acid; ascorbic acid glycoside such as ascorbic acid glucoside (VC glucoside) (ascorbic acid-2-glucoside (AA2G)); ascorvir Ascorbic acid monophosphate esters such as phosphoric acid, magnesium ascorvir phosphate (phosphate-L-ascorvir magnesium), sodium ascorvir phosphate, isostearyl ascorvir phosphate, ascorvir phosphate palmitate; ascorbic acid diphosphate ester; trilin ascorbic acid Acid ester; ascorbic acid sulfate ester; ascorbic acid tocopherol derivative such as (ascorvir / tocopheryl) phosphoric acid and ascorvir tocopheryl maleate; ascorbic acid silicone such as methylsilanol ascorbate, or salts thereof, and the like are preferable. One or more selected from the group consisting of ascorbic acid alkyl esters, ascorbic acid monophosphate esters, L-ascorbic acid glucosides, ascorbic acid tocopherol derivatives, ascorbic acid glycerin esters, and salts thereof. More preferably, it is one or more selected from the group consisting of an ascorbic acid alkyl ester, an ascorbic acid monophosphate ester, an L-ascorbic acid glucoside, an ascorbic acid tocopherol derivative, and salts thereof.

Preferred vitamin C derivatives as the component (B) of the present invention include ascorbyl tetraisopalmitate, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, disodium ascorbyl sulfate, 2-O-ethylascorbic acid, 3-O-ethyl. Ascorbic acid, ascorbic acid-2-glucoside, isostearyl ascorbyl phosphate disodium, ascorbyl palmitate 3 sodium palmitate; glyceryl ascorbic acid, bisglyceryl ascorbic acid, hexyl 3-glyceryl ascorbic acid, 3-glyceryl ascorbic acid, myristyl 3 -Glyceryl ascorbic acid, 3-lauryl glyceryl ascorbic acid, (ascorbyl / ascorbyl) phosphoric acid, (ascorbyl / tocoferyl) potassium phosphate, ascorbyl tocopheryl maleate and the like can be mentioned. Preferably, sodium ascorvir phosphate, magnesium ascorvir phosphate, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid; ascorbic acid-2-glucoside, isostearyl ascorvir phosphate disodium, palmitate ascorvir phosphate 3 Sodium, 3-glyceryl ascorbic acid, bisglyceryl ascorbic acid, hexyl 3-glyceryl ascorbic acid, 3-glyceryl ascorbic acid, myristyl 3-glyceryl ascorbic acid, 3-lauryl glyceryl ascorbic acid, (ascorvir / tocopheryl) potassium phosphate, and One or more selected from the group consisting of ascorbiltocopheryl maleate, more preferably sodium ascorbyl phosphate, magnesium ascorvir phosphate, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, One or more selected from the group consisting of ascorbic acid-2-glucoside, isostearyl ascorvir phosphate disodium, ascorbyl phosphate trisodium palmitate, and (ascorvir / tocopheryl) potassium phosphate, more preferably. , Sodium ascorvir phosphate, magnesium ascorvir phosphate, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, and ascorbic acid-2-glucoside, which is one or more selected from the group. More preferably, it is one or more selected from the group consisting of magnesium ascorvir phosphate, 3-O-ethylascorbic acid, and ascorbic acid-2-glucoside, and particularly preferably 3-O-ethylascorbic acid. is there.

Arbutin is obtained by binding glucose to hydroquinone, and the one in which the bond between hydroquinone and glucose is α-bond is called α-arbutin, and the one in which β-bond is β-arbutin is called β-arbutin. As the component (B) of the present invention, either α-arbutin or β-arbutin can be preferably used, but β-arbutin is more preferable.

Tranexamic acids include tranexamic acid, derivatives of tranexamic acid, and salts thereof. Tranexamic acid is a compound also called trans-4- (aminomethyl) cyclohexane-1-carboxylic acid, which may be synthesized by a known method or can be obtained as a commercially available product. The derivative of tranexamic acid is not particularly limited as long as it is pharmacologically or physiologically acceptable, and is, for example, a dimer of tranexamic acid; an amide form of tranexamic acid such as methyl tranexamic acid and ethylamide tranexamic acid; tranexamic acid. Examples thereof include hydroquinone esters; tranexamic acid vitamin esters such as vitamin A ester, vitamin E ester, and vitamin C ester; genticinic acid ester tranexamic acid; cetyl tranexamic acid; or tranexamic acid ester derivatives such as salts thereof. These tranexamic acid derivatives may be synthesized by a known method or can be obtained as a commercially available product. Among them, tranexamic acid is preferable as the component (B) of the present invention.

In the external composition for skin of the present invention, the total content of the component (B) with respect to the total amount of the external composition for skin is appropriately set depending on the balance with other components, but is preferable from the viewpoint of remarkably exerting the effect of the present invention. Is 0.01% by mass or more, more preferably 0.1% by mass or more, still more preferably 0.5% by mass or more, still more preferably 1% by mass or more.
The total content of the component (B) is preferably 10% by mass or less, more preferably 8% by mass or less, still more preferably 6% by mass or less, and particularly preferably 5% by mass or less, based on the total amount of the external composition for skin. is there.
The content of the component (B) is preferably 0.01 to 20% by mass, more preferably 0.01 to 10% by mass, still more preferably 0.1 to 8% by mass, based on the total amount of the external composition for skin. Even more preferably, it is 0.5 to 6% by mass, and particularly preferably 1 to 5% by mass.

When nicotinamide is contained as the component (B), the content of nicotinamide is preferably 1.5 to 20% by mass, more preferably 2 to 15% by mass, based on the total amount of the external composition for skin. It is even more preferably 3 to 10% by mass, and even more preferably 3 to 8% by mass.

When the component (B) contains a vitamin C derivative and salts thereof, the content of the vitamin C derivative and these salts is preferably 0.01 to 10% by mass, based on the total amount of the external composition for skin. It is preferably 0.5 to 8% by mass, more preferably 1 to 5% by mass, and even more preferably 1 to 3% by mass.

When arbutin is contained as the component (B), the content of arbutin is preferably 0.01 to 5% by mass, more preferably 0.1 to 4.8% by mass, based on the total amount of the external composition for skin. It is still more preferably 0.5 to 4.5% by mass, even more preferably 0.5 to 4% by mass, and particularly preferably 1 to 3% by mass.

When tranexamic acids are contained as the component (B), the content of tranexamic acids is preferably 0.01 to 10% by mass, more preferably 0.5 to 8% by mass, based on the total amount of the external composition for skin. It is more preferably 0.5 to 5% by mass, even more preferably 1 to 3% by mass, and particularly preferably 1.2 to 3% by mass.

The total content of the component (B) with respect to 1 part by mass of the total content of the component (A) in the external composition for skin of the present invention is not particularly limited, but is preferably 0 from the viewpoint of significantly exerting the effect of the present invention. 0002 to 10000 parts by mass, more preferably 0.001 to 8000 parts by mass, still more preferably 0.01 to 5000 parts by mass, even more preferably 0.1 to 1000 parts by mass, particularly preferably 0.5 to 500 parts by mass. It is a department.

[Component (C)]
From the viewpoint of further enhancing the effect of the present invention, the external composition for skin of the present invention contains, in addition to the components (A) and (B), phenoxyethanol, dipropylene glycol, and an amphipathic component as the component (C). Contains one or more components selected from the group.

An amphipathic component refers to all compounds in which both a hydrophilic group and a hydrophobic group (parent oil group) are present in one molecule, and as a result, they are compatible with both the aqueous phase and the oil phase (organic phase). ..

Such amphipathic components are not particularly limited, and examples thereof include alkylene oxide derivatives, 2-methacryloyloxyethyl phosphorylcholine-containing polymers, divalent carboxylic acid esters, and alkanediols having 5 to 10 carbon atoms. As the component (C) of the present invention, any one of these compounds alone or a combination of two or more thereof can be used.

The component (C) is preferably phenoxyethanol, an alkylene oxide derivative represented by the following general formula (II), a 2-methacryloyloxyethyl phosphorylcholine / butylmethacrylate copolymer, (eicosanedioic acid / tetradecanedioic acid) decaglyceryl. , Cyclohexanedicarboxylic acid bisethoxydiglycol, diethylhexyl succinate, diethoxyethyl succinate, and one or more selected from the group consisting of alkanediols having 5 to 10 carbon atoms.

The alkylene oxide derivative used in the present invention is represented by the following formula (II).

Z- [O- (AO) _a (EO) _b- (BO) _c- H] _n (II)
(N in the formula is an integer from 1 to 9;
Z is a group obtained by removing n hydroxy groups from a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms;
AO is an oxyalkylene group having 3-4 carbon atoms;
EO is an oxyethylene group;
BO is an oxyalkylene group having 4 carbon atoms;
a, b, and c are the average number of moles of AO, EO, and BO, respectively, which are 0 to 200 independently; a, b, and c are not all 0;
AO and EO may be added randomly or in blocks;
When n is 2 or more, the plurality of a, b, and c may be the same or different.
If Z is a hydrogen atom, n is 1).

The alkylene oxide derivative may be a compound represented by the following general formula (III).

Z- [O- (AO) _a (EO) _b- H] _n (III)
(N in the formula is an integer from 1 to 9;
Z is a group obtained by removing n hydroxy groups from a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms;
AO is an oxyalkylene group having 3-4 carbon atoms;
EO is an oxyethylene group;
a and b are the average number of moles of AO, EO, and BO, respectively, which are 0 to 200 independently; a and b are not all 0;
AO and EO may be added randomly or in blocks;
When n is 2 or more, the plurality of a and b may be the same or different.
If Z is a hydrogen atom, n is 1).

In the chemical formulas (II) and (III), Z is preferably a hydrogen atom or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, trimethylolpropane, erythritol, or penta, from the viewpoint of significantly exerting the effect of the present invention. A group obtained by removing n hydroxy groups from erythritol, alkyl glucoside, diglycerin, xylitol, dipentaerythritol, sorbitol, inositol, sucrose, trehalose, martitol or a hydroxy compound having 1 to 30 carbon atoms. More preferably, it is a group obtained by removing n hydroxy groups from a hydrogen atom or an alkyl monoalcohol having 4 to 24 carbon atoms, pentaerythritol, alkyl glucoside, glycerin, diglycerin or sorbitol, and even more preferably. , A hydrogen atom, an alkyl monoalcohol having 4 to 24 carbon atoms, an alkyl glucoside, diglycerin or a group obtained by removing n hydroxy groups from glycerin, and even more preferably a hydrogen atom and 4 to 24 carbon atoms. It is a group obtained by removing n hydroxy groups from 24 alkyl monoalcohols, diglycerin or glycerin.

In the chemical formulas (II) and (III), when Z is an alkyl monoalcohol having 4 to 24 carbon atoms, butyl alcohol, tetradecyltetraalcohol, cetanol, or stearyl alcohol is particularly effective from the viewpoint of significantly exerting the effect of the present invention. Is preferable, and butyl alcohol is more preferable.

In the chemical formulas (II) and (III), when Z is an alkyl glucoside, the alkyl glucoside having an alkyl group moiety having 1 to 24 carbon atoms is preferable, and the alkyl group moiety is carbon, from the viewpoint of significantly exerting the effect of the present invention. Alkyl glucosides having a number of 1 to 16 are more preferable, alkyl glucosides having an alkyl group moiety having 1 to 10 carbon atoms are even more preferable, and alkyl glucosides having an alkyl group moiety having 1 to 5 carbon atoms are particularly preferable.

The AOs of the chemical formulas (II) and (III) are oxyalkylene groups having 3 to 4 carbon atoms, and examples thereof include an oxypropylene group and an oxybutylene group (oxyn-butylene group, oxyisobutylene group, oxyt-butylene group). , Oxytrimethylene group, oxytetramethylene group and the like. The AO is preferably an oxypropylene group or an oxybutylene group, and more preferably an oxypropylene group.
BO is an oxyalkylene group having 4 carbon atoms, and examples thereof include an oxybutylene group (oxyn-butylene group, oxyisobutylene group, oxyt-butylene group), an oxytetramethylene group and the like. It is preferably an oxybutylene group.

In the alkylene oxide derivative used in the present invention, a, b, and c are independently 0 to 200, respectively. Each of a, b, and c is independently, preferably 1 to 200, more preferably 2 to 150, still more preferably 2 to 100, and particularly preferably 2 to 70.

In the chemical formula (II), a + b + c, which is the total number of each monomer unit of AO, EO, and BO, is preferably 3 or more, more preferably 5 or more, still more preferably 10 or more, from the viewpoint of significantly exerting the effect of the present invention. It is preferably 450 or less, more preferably 350 or less, still more preferably 300 or less, and particularly preferably 250 or less.

In the chemical formulas (II) and (III), a + b, which is the total number of each monomer unit of AO and EO, is preferably 3 or more, more preferably 5 or more, still more preferably 5 or more, from the viewpoint of significantly exerting the effect of the present invention. It is 10 or more. Further, a + b is preferably 400 or less, more preferably 300 or less, still more preferably 250 or less, and particularly preferably 200 or less, from the viewpoint of remarkably exerting the effect of the present invention.

The molecular weight of the alkylene oxide derivative used in the present invention is preferably 120 or more, more preferably 200 or more, still more preferably 300 or more, and particularly preferably 400 or more, from the viewpoint of significantly exerting the effect of the present invention.
The molecular weight of the alkylene oxide derivative is preferably 50,000 or less, more preferably 10,000 or less, still more preferably 5,000 or less.

The properties of the alkylene oxide derivatives of the formulas (II) and (III) are not limited as long as the effects of the present invention are exhibited, but from the viewpoint of significantly exhibiting the effects of the present invention, they are preferably in a semi-solid state at 25 ° C. It is a component that is in the form of a paste) to a liquid.

In addition, such alkylene oxide derivatives include polyoxyalkylene glyceryl ether, polyoxyalkylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyalkylene sorbit, polyoxyalkylene erythritol ether, polyoxyalkylene pentaerythritol ether, and polyoxyalkylene di. Glyceryl ether, polyoxyalkylene trimethylol propane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyalkylene xylitol, polyoxyalkylene dipentaerythritol, polyoxyalkylene inositol, polyoxyalkylene sucrose ether, polyoxyalkylene trehalose Examples include ether and polyoxyalkylene maltitol ether. Among them, polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene Alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbit, polyoxyethylene sorbit, polyoxypropylene erythritol ether, polyoxyethylene erythritol ether, polyoxyethylene penta Ellis Ritol Ether, Polyoxyethylene Polyoxypropylene Erythritol Ether, Polyoxypropylene Pentaerythritol Ether, Polyoxyethylene Polyoxypropylene Pentaerythritol Ether, Polyoxyethylene Diglyceryl Ether, Polyoxypropylene Diglyceryl Ether, Polyoxyethylene Polyoxypropylene Di Glyceryl Ether, Polyoxyethylene Trimethylol Propane, Polyoxypropylene Trimethylol Propane, Polyoxyethylene Polyoxypropylene Trimethylol Propene, Polyoxypropylene Glycol, Polyoxyethylene Polyoxypropylene Glycol, Polyoxybutylene Polyoxyethylene Polyoxypropylene Glycol , Polyoxyethylene xylitol, polyoxypropylene alkylenexylitol, polyoxyethylene polyoxypropylene xylitol, polyoxyethylene polyoxypropylene dipentaerythritol, polyoxyethylene dipentaerythritol, polyoxypropylene pentaerythritol, polyoxyethylene inositol, poly Oxypropylene inositol, polyoxyethylene polyoxypropylene inositol, polyoxyethylene sucrose ether, polyoxypropylene sucrose ether, polyoxyethylene polyoxypropylene sucrose ether, polyoxyethylene trehalose ether, polyoxypropylene trehalose ether, polyoxyethylene polyoxy Propylene trehalose ether, polyoxyethylene multitoll ether, polio One or more selected from the group consisting of xipylene maltitol ether and polyoxyethylene polyoxypropylene ether is preferable.
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside , Polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbit, polyoxyethylene sorbit, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene diglyceryl ether, poly One or 2 selected from the group consisting of oxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene trimethylolpropane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene glycol. Seeds and above are more preferred
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxybutylene polyoxy Ethylene polyoxypropylene alkyl glucoside, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene glycol, polyoxyethylene poly One or more selected from the group consisting of oxypropylene alkyl ethers is more preferable.
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene methyl glucoside, polyoxypropylene methyl glucoside , Polyoxyethylene methyl glucoside, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene polyoxypropylene decyltetradecyl ether One or more selected from the group consisting of are even more preferable.

Such an alkylene oxide derivative is not particularly limited as a commercially available product, and is, for example, WILBRIDE S-753 (polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.O.) (8EO) (5P. O.)), WILBRIDE MG2070 (polyoxybutylene polyoxyethylene polyoxypropylene methyl glucoside), Macbiobride MG-10E (polyoxyethylene methyl glucoside (10EO)), Macbiobride MG-20E (polyoxy) Ethylene methyl glucoside (20EO)), Macbiobride MG-20P (polyoxyethylene methyl glucoside (20PO)), Macbiobride MG-10P, Unilube 5TP-300KB (polyoxyethylene polyoxypropylene penta) Ellis Ritol Ether (5EO) (65PO)), Unilube 50MB-26 (Polyoxyethylene Polyoxypropylene Butyl Ether (17EO) (17PO)), Unilube 50MB-168 (Polyoxyethylene) Polyoxypropylene butyl ether (37EO) (38PO)), Unilube 50MB-11 (polyoxyethylene polyoxypropylene butyl ether (9EO) (10PO)), Unisafe 10P-8 (poly) Oxyethylene polyoxypropylene cetyl ether (10EO) (8PO)), Unilube MT-630B (polyoxyethylene polyoxypropylene decyltetradecyl ether (30EO) (6PO)), Solbure GS-01 (polyoxyethylene polyoxypropylene decyltetradecyl ether (24EO) (13PO)), Unilube MS-70K (polyoxypropylene stearyl ether (15PO)), Uniol HS- 1600D (Polyoxypropylene sorbit (25P.O.)), Pronon # 208 (Polyoxyethylene polyoxypropylene glycol (150E.O.) (35P.O.)), Uniol D-2000 (Polypropylene glycol (34P.O.)) )) Uniox G-1200 (polyoxyethylene glycerin (26EO)), Uniol TG-3000 (polyoxypropylene glycerin (50PO)), Unilube DGP-700 (polyoxypropylene diglyceryl ether (polyoxypropylene diglyceryl ether)) 9P. O. )), Unilube DGP-950 (polyoxypropylene diglyceryl ether (14PO)) (all manufactured by NOF CORPORATION); SY-DP14T (polyoxypropylene diglyceryl ether (14PO)), SY-DP9 (polyoxypropylene diglyceryl ether (9PO)), SY-DP14T (polyoxypropylene diglyceryl ether (14PO)) (all manufactured by Sakamoto Pharmaceutical Co., Ltd.); Blaunon GL- 26, (Polyoxyethylene glycerin (26EO)) (above, manufactured by Aoki Oil & Fat Co., Ltd.), Newpole GP-1000 (Polyoxypropylene glyceryl ether (16PO)), Newpole SP-750 ( Polyoxypropylene sorbitol (10P.O.)), Newpole PE-68 (Polyoxyethylene polyoxypropylene glycol (160EO) (30P.O.)), Newpole PE-78 (Polyoxyethylene polyoxy) Propylene Glycol (150EO) (35PO)), New Pole GEP-2800 (Polyoxyethylene Polyoxypropylene Glyceryl Ether (24EO) (24PO) (above, Sanyo Kasei Co., Ltd.) (Manufactured by); NIKKOL SG-G2424 (polyoxyethylene polyoxypropylene glyceryl ether (24EO) (24PO), NIKKOL SG-DTD630 (polyoxyethylene polyoxypropylene decyltetradecyl ether (30EO)) (6PO), NIKKOL SG-DTD620 (Polyoxyethylene polyoxypropylene decyltetradecyl ether (20EO) (6PO)), NIKKOL PEN-4612 (Polyoxyethylene polyoxypropylene decyltetradecyl) Ether (12EO) (6PO)) (manufactured by NOF CORPORATION); GLUCAM P-10 (polyoxypropylene methyl glucoside (10PO)), GLUCAM P-20 (polyoxypropylene methyl glucoside (polyoxypropylene methyl glucoside)) 20P.O.)) GLUCAM E-10 (polyoxyethylene methyl glucoside (10P.O.)), And GLUCAM E-20 (polyoxyethylene methyl glucoside (20P.O.)) (all manufactured by Lubrizol). Etc. can be used.

As commercially available products of alkylene oxide derivatives, from the viewpoint of remarkably exerting the effect of the present invention, Nieuport 50MB-26, Nieuport 50MB-168, Nieuport HS-1600D, Pronon # 208, Pronon # 124P, Uniol D-2000, Macbio Bride MG-10E, McBiobride MG-20E, McBiobride MG-10P, McBiobride MG-20P, WILBride MG2070, Nieuport 5TP-300KB, Nieuport 50TG-32, WILBRIDE S-753, Uniox G-1200, Unilube DGP-700, Unilube DGP-950, SY-DP14, SY-DP9, Nieuport GP-1000, Nieuport SP-750, Nieuport PE-68, Nieuport PE-78, Nieuport GEP-2800, NIKKOL SG -G2424, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, NIKKOL PEN-4612, NIKKOL SG-DTD620, NIKKOL SG-DTD630, Unilub MT-630B, Solbule GS-01, GLUC It is preferably one or more selected from the group consisting of -290.
Nieuport 50MB-26, Nieuport 50MB-168, Nieuport HS-1600D, Propafenone # 208, Propafenone # 124P, Nieuport D-2000, McBiobride MG-10E, McBiobride MG-20E, McBiobride MG-10P, Mac Biobride MG-20P, WILBRIDE MG2070, WILBRIDE S-753, Uniox G-1200, Unilube 50TG-32, Unilube DGP-700, Unilube DGP-950, SY-DP14, SY-DP9, Nieuport GP-1000, New Pole SP-750, Nieuport PE-68, Nieuport PE-78, Nieuport GEP-2800, NIKKOL SG-G2424, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, NIKKOL PEN-4612, NIKKOL SG -It is more preferable that it is one or more selected from the group consisting of DTD620, NIKKOL SG-DTD630, Uniluport MT-630B, Solbure GS-01, GLUCAM E-20 and Emargen PP-290.
Unilube 50MB-26, Unilube 50MB-168, WILBRIDE S-753, WILBRIDE MG2070, McBiobride MG-20P, McBiobride MG-10P, McBiobride MG-20E, McBiobride MG-10E, Unilube DGP-700 , Unilube DGP-950, SY-DP14, SY-DP9, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, NIKKOL PEN-4612, NIKKOL SG-DTD620, NIKKOL SG-DTD630, NIKKOL SG-DTD630 It is more preferable that one or more selected from the group consisting of GS-01 and GLUCAM E-20.
Unilube 50MB-26, Unilube 50MB-168, WILBRIDE S-753, WILBRIDE MG2070, McBiobride MG-20P, McBiobride MG-10P, McBiobride MG-20E, McBiobride MG-10E, Unilube DGP-700 , Unilube DGP-950, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, SY-DP14, and SY-DP9, one or more selected from the group.

The 2-methacryloyloxyethyl phosphorylcholine-containing polymer is a polymer obtained by polymerizing a monomer containing 2-methacryloyloxyethyl phosphorylcholine. The 2-methacryloyloxyethyl phosphorylcholine-containing polymer used in the present invention has Lipidure-PMB (2-methacryloyloxyethylphosphorylcholine-butyl methacrylate copolymer solution, polyquaternium-51), from the viewpoint of significantly exerting the effect of the present invention. One or more selected from the group consisting of Lipidure-HM (polymethacryloyloxyethyl phosphorylcholine) (both manufactured by NOF CORPORATION) is preferable, and Lipidure-PMB is more preferable.

The divalent carboxylic acid ester is a compound obtained by condensing a divalent carboxylic acid with a hydroxy group such as glycol or glycol ether, and is not particularly limited. For example, (eicosandioic acid / tetradecanedioic acid) decaglyceryl or cyclohexanedicarboxylic acid. Bisethoxydiglycol, bis 1,4-cyclohexanedicarboxylic acid (triethylene glycol monoethyl ether), bis adipate (diethylene glycol monoethyl ether), bis adipate (triethylene glycol monoethyl ether), and diethoxyethyl succinate , Diethylhexyl succinate, among which one selected from the group consisting of decaglyceryl (eicosanedioic acid / tetradecanedioic acid), bisethoxydiglycol cyclohexanedicarboxylic acid, diethoxyethyl succinate, and diethylhexyl succinate. Two or more are preferable, one or two selected from the group consisting of (eicosanedioic acid / tetradecanedioic acid) decaglyceryl and bisethoxydiglycolcyclohexanedicarboxylic acid is more preferable, and bisethoxydiglycolcyclohexanedicarboxylic acid is further preferable. .. The commercially available products are not particularly limited, but are: diethoxyethyl succinate (CRODAMOL DES), diethylhexyl succinate (CRODAMOL OSU) (all manufactured by Crowda Japan Co., Ltd.), Neosolue-Aqua, Neosolue-AquaS ((() Eikosandioic acid / tetradecanedioic acid) decaglyceryl), Neosolue-Aquolio (cyclohexanedicarboxylic acid bisethoxydiglycol) (all manufactured by Nippon Seika Co., Ltd.) and the like can be used.

The alkanediol has a carbon number of preferably 5 to 10, more preferably 5 to 8, and even more preferably 5 to 6 from the viewpoint of significantly exerting the effect of the present invention. For example, one or more selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol is preferable, and 1,2-pentanediol, 1,2-hexane. One or two selected from the group consisting of diols is more preferable, and 1,2-pentanediol is further preferable. The commercially available products are not particularly limited, but are HYDROLLITE-5, HYDROLLITE-5 Green (manufactured by Symrise Co., Ltd.), KMO-6 (manufactured by Osaka Organic Chemical Industry Co., Ltd.), Microcare Emorient PTGJ, and Microcare Emorient HXD (THOR). , Diol PD, Diol PD-V (manufactured by Higher Alcohol Industry Co., Ltd.), CleanBio-HD (manufactured by Kolon Life Science, Inc.), Lexgard (registered trademark) H (manufactured by Inolex Chemical Company), etc. can be used. ..

When the component (B) is a vitamin C derivative, the component (C) includes phenoxyethanol, an alkylene oxide derivative, a polymer containing 2-methacryloyloxyethyl phosphorylcholine, a divalent carboxylic acid ester, and an alkanediol having 5 to 10 carbon atoms. It is preferably one or more selected from the group consisting of, preferably an alkylene oxide derivative, a 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, a divalent carboxylic acid ester, and an alkane having 5 to 10 carbon atoms. More preferably, it is one or more selected from the group consisting of diols, and Z is a group obtained by removing n hydroxy groups from an alkyl monoalcohol having 4 to 24 carbon atoms or glycerin. It is more preferably one or more selected from the group consisting of the alkylene oxide derivative (II), the divalent carboxylic acid ester, and the alkanediol having 5 to 10 carbon atoms.
When the component (B) is albutin, the component (C) includes dipropylene glycol, an alkylene oxide derivative, a polymer containing 2-methacryloyloxyethyl phosphorylcholine, a divalent carboxylic acid ester, and an alkanediol having 5 to 10 carbon atoms. It is preferably one or more selected from the group consisting of, preferably an alkylene oxide derivative, a 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, a divalent carboxylic acid ester, and an alkane having 5 to 10 carbon atoms. More preferably, it is one or more selected from the group consisting of diols.
When the component (B) is a tranexamic acid, the component (C) includes dipropylene glycol, an alkylene oxide derivative, a polymer containing 2-methacryloyloxyethyl phosphorylcholine, a divalent carboxylic acid ester, and an alkane having 5 to 10 carbon atoms. It is preferably one or more selected from the group consisting of diols, and one or more selected from the group consisting of divalent carboxylic acid esters and alkanediols having 5 to 10 carbon atoms. More preferred.

The total content of the component (C) is not particularly limited and is appropriately set according to the type of water-soluble polysaccharide, the type of other compounding components, etc., but from the viewpoint of significantly exerting the effect of the present invention, the skin With respect to the total amount of the external composition, preferably 0.001% by mass or more, more preferably 0.01% by mass or more, still more preferably 0.1% by mass or more, still more preferably 0.3% by mass. % Or more, particularly preferably 0.5% by mass or more.
The total content of the component (C) is preferably 30% by mass or less, more preferably 20% by mass or less, still more preferably 15% by mass or less, still more preferably, based on the total amount of the external composition for skin. It is 10% by mass or less.
The total content of the component (C) is preferably 0.001 to 30% by mass, more preferably 0.01 to 20% by mass, still more preferably, based on the total amount of the external composition for skin. , 0.1 to 15% by mass, even more preferably 0.3 to 10% by mass, and particularly preferably 0.5 to 10% by mass.

The content of phenoxyethanol among the components (C) is not particularly limited, and is preferably 0.001 to 5% by mass, based on the total amount of the external composition for skin, from the viewpoint of significantly exerting the effect of the present invention. It is preferably 0.01 to 3% by mass, more preferably 0.05 to 2% by mass, and even more preferably 0.1 to 1% by mass.
The content of dipropylene glycol in the component (C) is not particularly limited, and is preferably 0.01 to 20% by mass with respect to the total amount of the external composition for skin from the viewpoint of significantly exerting the effect of the present invention. , More preferably 0.1 to 15% by mass, still more preferably 0.5 to 12% by mass, and even more preferably 1 to 10% by mass.
The content of the amphoteric component among the components (C) is not particularly limited, and is preferably 0.001 to 20 mass by mass with respect to the total amount of the external composition for skin from the viewpoint of significantly exerting the effect of the present invention. %, More preferably 0.01 to 15% by mass, even more preferably 0.1 to 10% by mass, and even more preferably 0.5 to 8% by mass.
The content of the divalent carboxylic acid ester and / or the alkylene oxide derivative among the amphoteric components of the component (C) is not particularly limited, and from the viewpoint of significantly exerting the effect of the present invention, the total amount of the external composition for skin is used. On the other hand, it is preferably 0.01 to 20% by mass, more preferably 0.1 to 15% by mass, still more preferably 0.5 to 10% by mass, and even more preferably 0.5 to 8% by mass.
Among the amphoteric components of the component (C), the content of the 2-methacryloyloxyethyl phosphorylcholine-containing polymer is not particularly limited, and from the viewpoint of significantly exerting the effect of the present invention, the content of the external composition for skin is relative to the total amount. Of the above, preferably 0.001 to 1% by mass, more preferably 0.005 to 0.5% by mass, still more preferably 0.01 to 0.4% by mass, and even more preferably 0.01 to It is 0.2% by mass.
Among the amphoteric components of the component (C), the content of alcandiol having 5 to 10 carbon atoms is not particularly limited, and from the viewpoint of significantly exerting the effect of the present invention, the content of the composition for external skin is relative to the total amount. , Preferably 0.01 to 20% by mass, more preferably 0.05 to 15% by mass, still more preferably 0.1 to 12% by mass, still more preferably 0.5 to 10% by mass, and particularly preferably 1 to 1. It is 10% by mass, more preferably 1 to 5% by mass.

The total content of the component (C) with respect to 1 part by mass of the total content of the component (B) in the external composition for skin of the present invention is not particularly limited, but is preferably 0 from the viewpoint of significantly exerting the effect of the present invention. 0005 to 3000 parts by mass, more preferably 0.002 to 200 parts by mass, further preferably 0.01 to 100 parts by mass, even more preferably 0.02 to 30 parts by mass, particularly preferably 0.1 to 10 parts by mass. %.

[Other ingredients]
In addition to the above-mentioned components (A) to (C), the external composition for skin of the present invention has other useful actions, such as an ultraviolet scattering agent, an ultraviolet absorber, and a preventive and / or repairing effect on DNA damage. Ingredients, whitening ingredients, anti-inflammatory ingredients, antibacterial ingredients, bactericidal ingredients, refreshing agents, organic acids, anti-glycation ingredients, cell activating ingredients, astringent ingredients, antioxidant ingredients, anti-aging ingredients, moisturizing ingredients, polyhydric alcohols , Various components such as keratin softening component, vitamins, blood circulation promoting component, sebum adsorbing component, peptide or derivative thereof, amino acid or derivative thereof may be blended in one type or in combination of two or more. The respective components are not particularly limited as long as they can be used in the fields of pharmaceuticals, quasi-drugs, cosmetics, etc., and any one can be appropriately selected and used. In addition, those corresponding to the following plurality of components can be added as components having any effect among them.

Examples of the ultraviolet scattering agent include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, silicic anhydride, cerium silicate, and hydrous silicic acid, and the like. Inorganic compounds of the above are coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica and talc, compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene and nylon, and silicone oils and fatty acids. Examples thereof include those treated with aluminum salts, alkyl titanates and the like. Among them, inorganic compounds such as zinc oxide, titanium oxide and iron oxide, and those in which these inorganic compounds are coated with inorganic powder such as aluminum hydroxide, hydrous silicic acid, mica or talc or silicone oil are preferable. When the ultraviolet scattering component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.001 to 35% by mass with respect to the total amount of the external composition for skin of the present invention. It is preferably about 0.1 to 25% by mass.

The ultraviolet absorber is not limited, but is preferably a salicylic acid-based ultraviolet absorber, a silicic acid-based ultraviolet absorber, a benzoylmethane-based ultraviolet absorber, an benzoic acid ester derivative ultraviolet absorber, a triazine derivative ultraviolet absorber, and the like. It may be a benzalmalonate derivative UV absorber, an octocrylene UV absorber, an imidazole sulfonic acid derivative UV absorber, a benzophenone derivative UV absorber, or the like.

Examples of the ultraviolet absorber include salicylic acid-based ultraviolet absorbers such as -2-ethylhexyl salicylate, homomentyl salicylate, and ethylene glycol salicylate; mono-2-ethylhexanoate glyceryl diparamethoxysilicate; glyceryl paramethoxysilicate 2 -Sulfonic acid-based ultraviolet absorbers such as ethylhexyl; 4-tert-butyl-4'-benzoylmethane-based ultraviolet absorbers such as methoxydibenzoylmethane; 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid An benzoic acid ester derivative such as a hexyl ester UV absorber; 2-ethylhexyl dimethoxybenzidenedioxoimidazolidine propionate; 2,2'-methylenebis [6- (2H-benzotriazo-lu 2yl) -4- (1,1,1) 3,3-Tetramethylbutyl) phenol]; 2,4-bis- [{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl] -6- (4-methoxyphenyl) -1,3,5 Triazine derivatives such as −triazine, diethylhexylbutamidotriazone, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine; dimethicodiethylbenzalmalonate and the like. Benzalmaronate derivative UV absorber; Octocrylene UV absorber such as 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester; 2-phenylbenzoimidazole-5-sulfonic acid, phenyldibenzoimidazole Imidazole sulfonic acid derivative UV absorbers such as disodium tetrasulfonate; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and salts thereof, dihydroxydimethoxybenzophenone, dihydroxybenzophenone, or tetra Examples thereof include benzophenone derivative ultraviolet absorbers such as hydroxybenzophenone.

In the present invention, such ultraviolet absorbers include, but are not limited to, 2-ethylhexyl paramethoxysilicate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2- [4- (diethylamino)-. 2-Hydroxybenzoyl] benzoic acid hexyl ester, dimethoxybenzylidene dioxoimidazolidine propionate 2-ethylhexyl, 2,2'-methylenebis [6- (2H-benzotriazol-2yl) -4- (1,1,3) , 3-Tetramethylbutyl) Phenol], 2,4-bis- [{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl] -6- (4-methoxyphenyl) -1,3,5- Triazine, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, dimethicodiethylbenzalmalonate, 2-cyano-3,3-diphenylpropa-2 One or more selected from the group consisting of 2-ethylhexyl ester of enoic acid and 2-phenylbenzoimidazole-5-sulfonic acid is preferable.

As the ultraviolet absorber, a commercially available product can be used, or a synthetic product can be used.

Commercially available products include, but are not limited to, Parsol EHS (manufactured by DSM Nutrition Japan), ESCAL 587 (manufactured by Ashland Japan), EusolexOS (manufactured by Merck), Parsol HMS (manufactured by DSM Nutrition Japan), Uvinul MC80 (manufactured by BASF), Parsol MCX (manufactured by DSM Nutrition Japan), Parsol 1789 (manufactured by DSM Nutrition Japan), Ubinal A Plus Granular, Soft Shade DH, Tinosorb M (manufactured by BASF), Milestab 3 / 100, Tinosorb S (manufactured by BASF), Uvasorb HEB, Ubinal T150 (manufactured by BASF), Heliosun OTZ (manufactured by O'Laughlin Industries), Parsol SLX (manufactured by DSM Nutrition Japan), Parsol 3 , Escalol 597 (manufactured by Ashland Japan), Parsol HS (manufactured by DSM Nutrition Japan), Eusolex232 (manufactured by Merck), NeoHeliopanAP (manufactured by Herman & Reimer), Ubinal M40, Escalol 567 Ashland Japan , Ubinal MS40 (manufactured by BASF), SEESORB107 (manufactured by Sipro Kasei), SEESORB100 (manufactured by Sipro Kasei), SEESORB106 (manufactured by Sipro Kasei).

In the external composition for skin of the present invention, the total content of the ultraviolet absorber is preferably 1% by mass or more, more preferably 3% by mass or more, still more preferably 6% by mass or more, based on the total amount of the composition. More preferably, it is 7% by mass or more. The total content of the ultraviolet absorber is preferably 20% by mass or less, more preferably 15% by mass or less, still more preferably 10% by mass or less, based on the total amount of the composition. The total content of the ultraviolet absorber is preferably 1 to 20% by mass, more preferably 3 to 15% by mass, still more preferably 5 to 10% by mass, still more preferably 7 with respect to the total amount of the composition. It is 10% by mass.

In the external composition for skin of the present invention, the ratio of the total content of the ultraviolet absorber to the component (B) is not particularly limited, but the ultraviolet absorber is preferably 0. 1 to 20 parts by mass, more preferably 0.1 to 15 parts by mass, still more preferably 0.1 to 10 parts by mass, even more preferably 0.1 to 6 parts by mass, particularly preferably 0.5 to 4 parts by mass. , Especially more preferably 1 to 2 parts by mass.
In the external composition for skin of the present invention, when the component (B) is one or more selected from the group consisting of vitamin C derivatives and tranexamic acids, the ratio of the total content of the ultraviolet absorber to the component (B). Is not particularly limited, but the ultraviolet absorber is preferably 0.5 to 20 parts by mass, more preferably 1 to 18 parts by mass, and further preferably 2 to 15 parts by mass with respect to 1 part by mass of the component (B). , Even more preferably 5 to 10 parts by mass.

Further, these ultraviolet scattering agents and ultraviolet absorbers may be compounded, supported or encapsulated in another component, and the combination thereof is not particularly limited.

Ingredients that have the effect of preventing and / or repairing DNA damage include, for example, components derived from animals (eg, artemia); components derived from plants (eg, cat's claw); DNA, DNA salts, RNA, RNA salts. Nucleic acid components such as. The content of the component having a DNA damage preventing and / or repairing action can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about the total amount of the external composition for skin of the present invention. It is 0.001 to 3% by mass, preferably about 0.01 to 1% by mass. When an animal component or a plant component is used, the content is preferably about 0.00001 to 0.1% by mass, more preferably about 0.00001 to 0.1% by mass, based on the total amount of the external composition for skin of the present invention in terms of an extract such as an extract. Is about 0.0001 to 0.01% by mass.

Examples of whitening ingredients include placenta; kojic acid; ellagic acid; phytic acid; rucinol; chamomile ET; hydroquinone, 4-methoxysalicylic acid potassium salt; linoleic acid and its derivatives; vitamin Cs such as ascorbic acid and its salts, and pantoten. Examples thereof include vitamins such as acids or derivatives thereof, batyl alcohol and the like. Further, a plant component having a whitening effect may be used as a whitening component, and such plant components include iris (iris), almond, aloe, acerola, oolong tea, ages, Japanese pepper, Japanese pepper, Japanese pepper, Japanese pepper, seaweed, and cucumber. Kuchinashi, Kujin, Chlorella, Rice, Rice Haiga, Oryzanol, Rice bran, Saishin, Sansho, Shiso, Shakuyaku, Senkyu, Souhakuhi, Soybean, Natto, Tea, Touki, Tokinsenka, Hamamelis, Benibana, Buttonpi, Yokuinin, Asenyaku Black bean, gentian, genjin, sage, daikon, tsutsuji, parsley, holly, hop, thyme, chow, chimpi, kanzo, chamomile, prun, shimotsukesou, purple kib, soybean, grapefruit, thorn, lemon, pine, neem, artichoke, sugina, Ingredients derived from Oobaku, Mematsuyoigusa, Bilberry, Himefuuro, Akkesiso, Seiyoushiroyanagi, Yukinoshita, Tsubokusa, Rosemary, Lavender, Devil's Claw, Sanshuyu and the like can be mentioned. When these plant components are used in the external composition for skin of the present invention, the form of the plant components is not particularly limited, but they can usually be used in the form of a plant extract (plant extract) or an essential oil. The names in parentheses described in the plant components are the scientific name, alias or crude drug name of the plant.

In the present invention, such whitening ingredients include, but are not limited to, placenta; kodiic acid; ellagic acid; phytic acid; lucinol; chamomile ET; hydroquinone; 4-methoxysalicylic acid potassium salt; linoleic acid and its derivatives; ascorbin. Acid, sodium ascorbate; iris, almond, aloe, acerola, ages, augon, auren, otogirisou, odorikosou, seaweed, cucumber, chlorella, rice, rice haiga, oryzanol, rice bran, perilla, shakyaku, soybean, tea, , Hamamelis, Buttonpi, Yokuinin, Kiwi, Sage, Parsley, Hiiragi, Hop, Thyme, Chouji, Chinpi, Kanzo, Chamomile, Prune, Shimotsukesou, Murasakikibu, Soybean, Grapefruit, Thorny, Lemon, Pine, Neem, Artichoke, Sugina , Mematsuyoigusa, Bilberry, Himefuuro, Akkesiso, Seiyoshiroyanagi, Yukinoshita, Tsubokusa, Rosemary, Lavender, Devil's Claw, and one or more selected from the group consisting of extracts extracted from Sanshuyu.
Placenta; Koujiic acid; Phytic acid; Hydroquinone; Ascorbic acid, Sodium ascorbate; Iris root extract, Almond oil, Aloe vera extract, Acerola extract, Agetsu extract, Ogon extract, Otogirisou extract, Odori kosou extract, Seaweed extract, Cucumber extract, Chamomile extract , Shakuyaku extract, Souhakuhi extract, Soybean extract, Cha extract, Shirocha extract, Tokinsenka, Hamamelis, Yokuinin extract, Hatomugi extract, Hop extract, Prune extract, Kanzo extract, Oil-soluble Kanzo extract, Shimotsukesou extract, Murasakikibu extract, Alpinia cutlet seeds Extract, Grapefruit extract, Izayoi rose extract, Lemon extract, Kiwi extract, Pine extract, Neem leaf extract, Artichoke extract, Sugina extract, Oobaku extract, Mematsuyoigusa extract, Evening primrose oil, Bilberry leaf extract, Himefuuro extract, Akkesiso extract, Seiyoshiroyanagi extract, Tsubokusa extract , Harpagophytam root extract, and Sanshuyu fruit extract are more preferably one or more selected from the group.

When the whitening ingredient described above is added to the external composition for skin of the present invention, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, with respect to the total amount of the external composition for skin. , About 0.0003 to 10% by mass, preferably about 0.01 to 5% by mass. When a plant extract is used, the content is, for example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass, based on the total amount of the external composition for skin in terms of an extract such as an extract. , More preferably 0.001 to 10% by mass.

Examples of the anti-inflammatory component include allantin, caramine, glycyrrhizinic acid or a derivative thereof or a salt thereof (for example, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, etc.), glycyrrhetinic acid or a derivative thereof or a salt thereof (for example, glycyrrhetinic acid, Stearyl glycyrrhetinate, etc.), zinc oxide, aminocaproic acid, azulene and its derivatives (eg, guaiazulene, azulene, etc.), tocopherol acetate, pyridoxin hydrochloride, menthol, camphor, terepine oil, indomethacin, salicylic acid or its derivatives, steroids or derivatives thereof Alternatively, salts thereof (eg, hydrocortisone, prednisolone), ufenamate, bufexamac, ibprofenpiconol, glycol salicylate, components derived from plants (eg, comfrey, auren, dokudami), and the like can be mentioned. It is preferably one or more selected from the group consisting of allantoin, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, aminocaproic acid, azulene and its derivatives, or dokudami extract, and more preferably. One or more selected from the group consisting of allantoin, dipotassium glycyrrhizinate, glycyrrhetinic acid, and aminocaproic acid. When the anti-inflammatory component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.0003 to 10 with respect to the total amount of the external composition for skin of the present invention. It is by mass, preferably about 0.01 to 5% by mass.

Examples of antibacterial or bactericidal components include chlorhexidine, salicylic acid, benzethonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, popidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclosan, and triclosan. , Photosensitizer 101, Photosensitizer 201, Paraben, Phenoxyethanol, Alkyldiaminoglycine hydrochloride, Cetylpyridinium chloride, Cetyltrimethylammonium chloride, Pyroctolamine, Zincpyridion, Myconazole or its salts, Chlorhexidine, Glyceryl caprylate, Ethylhexylglycerin, Butylcarbamine Examples thereof include propynyl acid iodide, caprylhydroxamic acid, phenethyl alcohol, methylisothiazolinone, sorbic acid, β-glycyrrhetinic acid, azelaic acid, components derived from plants (eg, clara, rosemary, quail, eucalyptus, etc.) ..
Among them, salicylic acid, benzalkonium chloride, ethanol, cetylpyridinium chloride, cetyltrimethylammonium chloride, gluconic acid, isopropylmethylphenol, paraben, phenoxyethanol, cetylpyridinium chloride, zincpyridionium, chlorobutanol, ethylhexylglycerin, propynyl iodide butylcarbamate, One or more selected from the group consisting of caprylhydroxamic acid, sorbic acid, β-glycyridinium, rosemary extract, and eucalyptus extract is preferable. When an antibacterial component or a bactericidal component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.0003 with respect to the total amount of the external composition for skin of the present invention. It is 10% by mass, preferably about 0.001 to 5% by mass.

Examples of the refreshing agent include menthol and its derivatives, camphor, borneol, geraniol, cineole, anethole, limonene, eugenol and other terpenes (these may be d-form, l-form or dl-form); eucalyptus oil. , Bergamot oil, peppermint oil, cool mint oil, spare mint oil, eucalyptol oil, camphor oil, keihi oil, rose oil, terpene oil and other essential oils. Of these, a combination with l-menthol, menthyl glyceryl ether, menthol lactate, menthyl 3-hydroxybutyrate, mentoxypropanediol, camphor, eucalyptus oil, peppermint oil, and peppermint oil is preferable. When a refreshing agent is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, 0.001 to 5 mass by mass with respect to the total amount of the external composition for skin of the present invention. % Or more, preferably 0.005 to 3% by mass or more, and more preferably 0.01 to 1% by mass or more.

Examples of the organic acid include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamate acid, succinic acid, oxalic acid, fumaric acid, malonic acid, maleic acid, propionic acid, malic acid, salicylic acid, and glycolic acid. Examples thereof include phytic acid, tartaric acid, acetic acid, lactic acid, pantothenic acid, glycyrrhetinic acid, alginic acid, ascorbic acid, benzoic acid, adipic acid, glutamic acid, azelaic acid and salts thereof. Examples of the salt include mineral acid salts such as sulfuric acid, hydrochloric acid or phosphoric acid, organic acid salts such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal salts and ammonium salts. Examples thereof include basic amino acid salts and amine salts such as triethanolamine. Among them, one or more selected from the group consisting of gluconic acid, citric acid, glutamic acid, succinic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, lactic acid, and glycyrrhetinic acid are more preferable.

Examples of anti-glycation components include Budreja axilaris leaf extract, seaweed fruit extract, edelweiss extract, ginkgo extract, cherry leaf extract, pomegranate extract, sardine extract, sardine extract, sardine extract, dokudami extract, bilberry leaf extract, etc. Green tea extract, tea extract, marronnier extract, roma chamomile extract, yomogi extract and other plant extracts, evening primrose oil, Amler fruit, fruit juice or their extracts, L-arginine, L-lysine, hydrolyzed casein, hydrolyzable tannin , Carnosin and the like. When the anti-glycation component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.0003 to 10 with respect to the total amount of the external composition for skin of the present invention. It is by mass, preferably about 0.001 to 5% by mass.

Examples of the cell activating component include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid: vitamins such as retinol, thiamine, riboflavin, pyridoxin hydrochloride, pantothenic acid and pyroquinolinquinones; gluconic acid, phytic acid, Α-Hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponins, allantin, placenta, proteoglycans, photosensitizer 301, plants (eg soybeans, bilberries, lemongrass, aloe vera, chlorella, ginger, whey, whey, whey, whey) , Hops, carrots, etc.); royal jelly, royal jelly extract; whey, yogurt extract, whey-derived extract such as hydrolyzed milk protein, yeast extract and the like. When the cell activating component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.0003 to the total amount of the external composition for skin of the present invention. It is 10% by mass, preferably about 0.001 to 5% by mass.

Convergent components include, for example, metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc paraphenol sulfonate, zinc sulfate, potassium aluminum sulfate, basic aluminum lactate zinc; tannic acid, citric acid, lactic acid. For organic acids such as succinic acid, plants (eg seaweed, thyme, tea, oolong tea, green tea, otogirisou, hamamelis, biwa, buttonpi, yukinoshita, louisbos, lotus, artichoke, chamomile, eucalyptus, lemon, rosemary, crackle, etc.) Derived components and the like can be mentioned. When the astringent component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.0003 to 20 mass with respect to the total amount of the external composition for skin of the present invention. %, Preferably about 0.01-10% by mass.

Antioxidant components include, for example, butylhydroxyanisole, dibutylhydroxytoluene, sodium hydrogen sulfite, sodium pyrosulfate, erythorbic acid and its salts, ascorbic acid and its salts, flavonoids, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase. , Superoxide dismutase, thioredoxin, taurine, thiotaurine, hipotaurine, plants (eg, otogirisou, cucumber, bilberry, ginger, kudamonotokeisou, grapefruit, shakuyaku, shimotsukesou, shiso, watermelon, sage, sage, sage, Ingredients derived from chimpi, himefuro, biwa, benibana, buttonpi, hop, eucalyptus, yukinoshita, ruibos, lemongrass, soybean, yomogi, mematsuyoigusa, rosemary, lavender, etc. can be mentioned. When the antioxidant component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.00001 to 10% by mass with respect to the total amount of the external composition for skin of the present invention. , It is preferably about 0.0001 to 5% by mass, and more preferably 0.001 to 5% by mass.

Examples of anti-aging ingredients include hydrolyzed soybean protein, retinoids (retinol, retinoic acid, retinal, etc.), pangamic acid, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone. , Peptides (Caprooil Tetrapeptide-3, Oligopeptide-24, etc.), Plants (Artichoke, Izayoibara, Seaweed, Bilberry, Shirakaba, Broadleaf Plantain, Touki, Ogon, Otogirisou, Comfrey, Neem, Novara, Hiougi, Himefuuro , Bodaiju, Buttonpi) and the like. Among them, hydrolyzed soy protein, retinol, retinyl acetate, retinol palmitate, caprooil tetrapeptide-3, oligopeptide-24, artichoke leaf extract, seaweed extract, bilberry leaf extract, comfrey leaf extract, neem leaf extract, Himefuuro Extracts are preferred. When the anti-aging component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.0003 to 10 with respect to the total amount of the external composition for skin of the present invention. It is by mass, preferably about 0.01 to 5% by mass.

Moisturizing ingredients include, for example, amino acids such as alanine, serine, aspartic acid, glycine, proline, hydroxyproline, glucosamine, theanine, arginine and derivatives thereof; glycerin, 1,3-propanediol, 1,3-butanediol and the like. Polyhydric alcohols; sugar alcohols such as sorbitol, xylitol, erythritol, maltose-sucrose condensate (glucooligosaccharide), hydrolyzed xylan (xylooligosaccharide), glyceryl glucoside; glycosyltrehalose, trehalose; ceramide, glucosylceramide, cholesterol, phytosterol, Cholesterol derivatives, phytosterol derivatives ;; phospholipids such as lecithin and hydrogenated lecithin; NMF-derived components such as lactic acid, sodium lactate, sodium pyrrolidone carboxylate, urea; hyaluronic acid (including hydrolyzed hyaluronic acid, low molecular weight hyaluronic acid, etc.) Hyaluronic acid salts (eg, sodium hyaluronate, zinc hyaluronate, low molecular weight zinc hyaluronate, etc.); Hyaluronic acid derivatives (acetylated hyaluronic acid or salts thereof (eg, acetylated sodium hyaluronate, acetylated zinc hyaluronate, etc.) ), Crosslinked hyaluronic acid derivative (hyaluronic acid crosspolymer Na, etc.), Na carboxymethyl hyaluronic acid, unsaturated hyaluronic acid or a salt thereof, hydrolyzed alkyl hyaluronate (C12-13) glyceryl, cationized hyaluronic acid derivative (hyaluronic acid) (Hydroxypropyltrimonium, etc.), dimethylsilanol hyaluronate, etc.); Chondroitin sulfate or a salt thereof (sodium chondroitin sulfate, potassium chondroitin sulfate, sodium dermatane sulfate, potassium dermatane sulfate, etc.); heparin analog, collagen, elastin, keratin, chitin, Chitosan and the like and their hydrolyzates; hydroxyethylurea; components derived from plants (eg, aloe, seaweed, cucumber, chlorella, lemongrass, chamomile, hamamelis, cha, perilla, grapefruit, amachazuru, etc.), etc. .. Among them, glycine, arginine, glycerin, 1,3-propanediol, 1,3-butanediol, glycosyl trehalose, ceramide, glucosyl ceramide, cholesterol, cholesterol derivative, phytosterol derivative, hydrogenated lecithin, lactic acid, sodium lactate, pyrrolidone carboxylic acid. Sodium, urea, hydrolyzed hyaluronic acid, low molecular weight hyaluronic acid, sodium hyaluronate, zinc hyaluronate, low molecular weight zinc hyaluronate, acetylated hyaluronic acid, hyaluronic acid crosspolymer Na, hydroxypropyltrimonium hyaluronate, dimethylsilanol hyaluronate , Collagen, elastin, keratin, hydroxyethylurea, seaweed extract, chamomile extract, hamamelis extract, amachazuru extract, one or more selected from them is preferable. When a moisturizing ingredient is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.001 to 20 mass with respect to the total amount of the external composition for skin of the present invention. %, preferably about 0.01-10% by mass.

Examples of the polyhydric alcohol include diols having 2 to 4 or 11 carbon atoms or more, polyhydric alcohols having 3 or more hydroxy groups, and the like, for example, glycerin, diglycerin, triglycerin, propylene glycol, 1,3-. Examples thereof include butanediol, 1,3-propanediol, ethylene glycol, diethylene glycol, isopylene glycol, and 1,3-butylene glycol. Among them, one or a combination of two or more selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-propanediol, and 1,3-butylene glycol is preferable. When the polyhydric alcohol is blended, its content can be appropriately selected in consideration of the feeling of use on the skin and the moisturizing effect, but for example, about 0.1 to 1 with respect to the total amount of the external composition for skin of the present invention. It is 20% by mass, preferably about 0.5 to 15% by mass.

Examples of the keratin softening component include adipic acid, lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, citric acid, fruit acid, phytic acid, urea and sulfur. Of these, a combination with lactic acid, sodium lactate, glycolic acid, salicylic acid, phytic acid, and citron is preferable. When the keratin softening component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, 0.0001 to 50 mass with respect to the total amount of the external composition for skin of the present invention. %, preferably about 0.001 to 50% by mass, more preferably about 0.01 to 25% by mass.

Examples of vitamins include retinol derivatives such as retinol, retinol acetate, retinol palmitate, retinol propionate, and retinol linoleate, retinal, retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoate, and d-δ-toco. Vitamin A such as ferryl retinoate, α-tocopheryl retinoate, β-tocopheryl retinoate; pros such as β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, ekinenone Vitamin A; δ-tocopherol, dl-α-tocopherol succinate dl-α-tocopherol, succinate dl-α-tocopherol calcium, tocopherol nicotinate, dl-α-tocopherol acetate, tocopherol linoleate, (linoleic acid / olein) Acids) Vitamin Es such as tocopherols; Vitamin B1s such as γ-orizanol, thiamine, and salts thereof (eg, dibenzoylthiamine hydrochloride, thiamin hydrochloride, thiaminniphosphate); riboflavin, flavin mononucleotide, flavin Vitamin B2s such as adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinic acid ester, and salts thereof; benzyl nicotinate, methyl nicotinate, nicotinic acid, etc. Nicotinic acids other than the above component (A); Vitamin Cs such as ascorbic acid and sodium ascorbate; Vitamin Ds such as methylhesperidine, ergocalciferol and cholecalciferol; Vitamin Ks such as phylloquinone and farnoquinone; Pyridoxin hydrochloride, Vitamin B6s such as pyridoxin acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, pyridoxamine hydrochloride, vitamin B12s such as cyanocobalamine, hydroxocobalamine, deoxyadenosylcobalamine; folic acids such as folic acid and pteroylglutamic acid; pantothenic acid, pantoten Pantothenic acids such as calcium acid, pantothenyl alcohol (pantenol), D-pantethein, D-pantetin, coenzyme A, pantothenyl ethyl ether, calcium pantethein sulfonate; biotins such as biotin, biocithin; in addition, carnitine, Ferraic acid, α-lipoic acid, ollotic acid, γ-orizanol, pyroquinolinquinone, hesperidin And vitamin-like acting factors such as glucosyl hesperidin, ubiquinone, and salts thereof. Of these, combinations with B vitamins, vitamin Cs, vitamin Es, vitamin As, and vitamin-like acting factors are preferable, and in particular, pyridoxine hydrochloride, panthenol alcohol (panthenol), riboflavin, cyanocobalamin, ascorbic acid, and dl-α acetate. -One or more selected from the group consisting of tocopherol, retinol, retinol palmitate, retinol propionate, retinol acetate, pyrroquinolinquinone or a salt thereof, ubiquinone, and γ-orizanol are more preferable. When the vitamins are blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.001 to 30 mass with respect to the total amount of the external composition for skin of the present invention. %, preferably about 0.01 to 25% by mass, more preferably about 0.01 to 20% by mass.

Examples of blood circulation promoting components include plants (for example, Otaneninjin, Ashitaba, Arnica, Ginkgo, Angelica acutiloba, Enmeisou, Dutch oak, Chamomile, Roman chamomile, Carrot, Gentiana, Gobo, Rice, Sanzashi, Shiitake, Shokyo, Seiyousanzashi, etc. Ashitaba, Senkyu, Senburi, Thyme, Chouji, Chinpi, Angelica, Tounin, Tohi, Carrot, Garlic, Butcher Bloom, Grape, Button, Maronie, Melissa, Yuzu, Yokuinin, Rosemary, Rosehip, Peach, Anzu, Walnut, Corn ); Dl-α-tocopherol acetate, tocopherol nicotinate, glucosyl hesperidin, hesperidin, caffeine, angelica acutiloba, gamma oryzanol, capsaicin, benzyl nicotinate and the like. When a blood circulation promoting component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.00001 to 10 with respect to the total amount of the external composition for skin of the present invention. It is by mass, preferably 0.0001 to 5% by mass, and more preferably about 0.001 to 5% by mass. When a plant-derived component is used, the content is, for example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass, based on the total amount of the external composition for skin in terms of an extract such as an extract. %, More preferably 0.001 to 10% by mass.

Examples of the sebum-adsorbing component include talc, mica, hydroxyapatite, zinc oxide, aluminum silicate and the like. Of these, mica, hydroxyapatite, and zinc oxide are preferable, and mica is particularly preferable. When the sebum-adsorbing component is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about 0.001 to 35 with respect to the total amount of the external composition for skin of the present invention. It is by mass, preferably about 0.1 to 25% by mass.

Examples of the peptide or its derivative include keratin-degrading peptide, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, succinylated atelocollagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride. Hydrolyzed collagen, elastin-degrading peptide, conchiolin-degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptide, water Examples thereof include degraded wheat protein, casein-degraded peptide, acylated peptide (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.). Among them, it consists of keratin-degrading peptide, hydrolyzed keratin, fish-derived collagen elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, succinylated atelocollagen, elastin-degrading peptide, hydrolyzed silk, soybean proteolytic peptide, and hydrolyzed soybean protein. A combination with one or more selected from the group is more preferable. When a peptide or a derivative thereof is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, from about 0.0001 to the total amount of the external composition for skin of the present invention. It is 35% by mass, preferably about 0.001 to 10% by mass.

Examples of the amino acid or a derivative thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, and the like. Cistine, methionine, leucine, isoleucine, valine, histidine, threonine, tyrosine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosin, creatine, epsilon aminocaproic acid, tryptophan, ornithine, di (lauroyl glutamate) Phytosteryl / octyldodecyl), di lauroyl glutamate (octyldodecyl / phytosteryl / behenyl) and the like can be mentioned. Further, these amino acids or derivatives thereof may be solvates such as hydrates, and may be d-form, l-form, or dl-form. Among them, one or more selected from the group consisting of l-form amino acids and derivatives thereof is preferable.

In addition to the components (A) to (C), the external composition for skin of the present invention may be used in the fields of pharmaceuticals, quasi-drugs, cosmetics, etc., depending on the intended use or dosage form in addition to the above-mentioned components. Ingredients usually used may be appropriately blended. The components that can be blended are not particularly limited, but are, for example, bases or carriers, surfactants, thickeners, antioxidants, preservatives, preservatives, pH adjusters, chelating agents, stabilizers, and irritation reducing agents. , Colorants, dispersants, fragrances and other additives can be added. In addition, these components can be blended alone or in any combination of two or more. Further, these contents can be appropriately determined from a conventionally known range within a range that does not impair the effects of the present invention. Further, those corresponding to the following plurality of components can be added as components having any function among them.

As the base or carrier, an aqueous base such as water; liquid paraffin, liquid isoparaffin, squalane, vaseline, paraffin, microcrystallin wax, polybutene, polyethylene powder, gelled hydrocarbon (plastibase, etc.), ozokelite, α-olefin oligomer , Light liquid paraffin, hydrocarbons such as light iso liquid paraffin; methyl polysiloxane, crosslinked methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicone, alkyl modified silicone, crosslinked alkyl modified silicone, amino modified silicone, polyether Modified Silicone, Polyglycerin Modified Silicone, Crosslinked Polyether Modified Silicone, Crosslinked Alkylene Modified Silicone, Silicone / Alkyl Chain Co-modified Polyether Modified Silicone, Silicone / Alkyl Chain Co-modified Polyglycerin Modified Silicone, Polyether Modified Branched Silicone , Silicone oils such as polyglycerin modified branched silicone, acrylic silicone, phenyl modified silicone, silicone resin; higher alcohols such as setanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, isostearyl alcohol, phytosterol, cholesterol; Higher fatty acids such as isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, and behenic acid; cellulose derivatives such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose; polyvinylpyrrolidone; polyvinylbutyrate; polyethylene glycol; dioxane Polyester butylene glycol adipate; isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythlit tetra2-ethylhexanoate, diisopropyl adipate, decyl oleate, isodecyl oleate, Hexyldecyl dimethyloctanoate, diisopropyl sebacate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, diisopropyl adipate, isotorideyl isononanoate, cetyl lactate, isostearyl isostearate, 12- Cholesteryl hydroxystearyl acid, cholesteryl stearate, cholesteryl oleate, macadamia nut fatty acid fi Tosteryl, phytosteryl oleate, dextrin palmitate, inulin stearate, hydrogenated jojoba oil, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, neopentyl glycol dicaprate, tri2-ethylhexyl trimeritate, tritritrimeritate Decyl, Trimethylol propane tri-2-ethylhexylate, Trimethylol propane triisostearate, Pentaerythritol tetra-2-ethylhexanoate, Glycerin tri-2-ethylhexanoate, Trimethylolpropane triisostearate, Tri (caprylic acid / Capric acid) glyceryl, tri (capric acid / capric acid / myristic acid / stearic acid) glyceryl, oleic oleate, di lauroyl glutamate (phytosteryl / octyldodecyl), di lauroyl glutamate (octyldodecyl / phytosteryl / behenyl), triethyl citrate , Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dipentaerynorail, dipentaerythrityl tripolyhydroxystearate, tri (bechenic acid / isostearic acid / eicosandiic acid) glyceryl-like esters Kinds; waxes such as jojoba oil, miuro, candelilla wax, rice bran, cotton wax, carnauba wax, lanolin; avocado oil, flaxseed oil, camellia oil, macadamia nut oil, corn oil, olive oil, safflower oil, kyonin oil, cinnamon oil , Johoba oil, grape seed oil, sunflower oil, almond oil, shea butter, southern ka oil, rapeseed oil, sesame oil, cacao butter, coconut oil, hardened coconut oil, palm oil, palm kernel oil, mokuro kernel oil, mokuro, wheat germ Oils, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, teaseed oil, evening primrose oil and other fats and oils; polysaccharides such as dextrin and maltodextrin; vinyl such as carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer. High polymers; lower alcohols such as ethanol and isopropanol ;; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol; water and the like. As the base or carrier selected from these components, one type may be used alone, or two or more types may be used in combination. Moreover, the amount used thereof is appropriately selected from a range known to those skilled in the art. When the external composition for skin of the present invention contains water, the content thereof is not particularly limited as the amount of water varies depending on the form of the cosmetic. For example, the amount of water is preferably 5 to 99%, more preferably 8 to 95%, and even more preferably 10 to 90% with respect to the total amount of the external composition for skin of the present invention.

Examples of the surfactant include sorbitan monoisostearate, sorbitan monostearate, tetra-2-ethylhexyl diglycerol sorbitan, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate and olive oil fatty acid sorbitan. Polysorbate fatty acid ester; polyoxyethylene monolaurate (20) sorbitan, polyoxyethylene monolaurate (80) sorbitan, polyoxyethylene monostearate (20) sorbitan, polyoxyethylene monooleate (20) sorbitan, isostearic acid Polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene (20) sorbitan; glycerin fatty acid ester such as glycerin monooleate, glycerin monostearate, and glycerin monomillistate; glycerin such as monoisostearyl glyceryl ether and monomyristyl glyceryl ether. Alkyl ether; polyglycerin fatty acid esters such as diglyceryl monostearate, decaglyceryl decasterate, decaglyceryl decaisostearate, and diglyceryl diisostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; poly Hardened castor oil derivatives such as oxyethylene cured castor oil 40, polyoxyethylene cured castor oil 50, polyoxyethylene cured castor oil 60, polyoxyethylene cured castor oil 80; polyoxyethylene such as polyoxyethylene monococonut oil fatty acid glyceryl Glycerin fatty acid ester; Polyoxyethylene alkyl ether such as polyoxyethylene cetyl ether; Polyoxyethylene (20) phytosterol, polyoxyethylene (30) phytosterol, polyoxyethylene (25) phytostanol, polyoxyethylene (30) cholestanol Polyoxyethylene sterol, hydrogenated sterol, etc .; sucrose fatty acid ester; polyoxyalkylene alkyl (or alkenyl) ether sulfate, ether carboxylate, alkyl phosphate ester salt, N-acyl amino acid salt, acylated taurate; stearyl; Amines such as amines and oleylamines; polyoxyethylene / methylpolysiloxane copolymers, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone and the like. Surfactants; Naturally-derived surfactants such as lecithin, hydrogenated lecithin, saponin, sodium surfactin, cholesterol, and bile acids can be exemplified.

Examples of the thickener include gums (gellan gum, xanthan gum, sclerothium gum, locust bean gum, biosaccharide gum, tamarind gum, quince seed, arabic gum, tara gum, guar gum, galactan, arabic gum, tragacanth gum, etc.); Caraginan, curdran, succinoglucan; heparin analogs; alginic acids (alginic acid, sodium alginate, propylene glycol alginate, etc.); agar (including agarose); gelatin, pectin; purulan; mannan; polyvinyl alcohol, polyvinylpyrrolidone, polyvinylmethylmethyl Vinyl thickeners such as ether and carboxyvinyl polymers, cellulose thickeners such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose and hydrophobic hydroxypropyl methyl cellulose, Dextran, alkyl methacrylate copolymer, sodium polyacrylate, bentonite, dextrin fatty acid ester, dimethyl distearyl ammonium hectrite, polyethylene glycol, macrogol, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, (acryloyl) Dimethyltaurine ammonium / vinylpyrrolidone) copolymer and the like can be mentioned. Among them, xanthan gum, alkyl methacrylate copolymer, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone, carboxyvinyl polymer, dimethyl distearyl ammonium hectrite, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer. , (Acryloyldimethyltaurine ammonium / vinylpyrrolidone) copolymer is preferred.

Examples of the antioxidant include ubiquinones such as dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, tocopherol, tocopherol derivative, erythorbic acid, sodium erythorbic acid, L-cysteine hydrochloride, and coenzyme Q10. Examples thereof include lignans such as sesamine, curcumin, capsaicin, gingerol, resveratrol, anthocyanin, cyanidin, bilberry extract, and analogs or derivatives thereof.

Examples of preservatives or preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxy. Examples thereof include benzyl benzoate, methyl paraoxybenzoate, benzyl alcohol, chlorobutanol, sorbic acid and salts thereof, chlorhexidine gluconate, methylisothiazolinone, propynyl iodide butylcarbamate, caprylhydroxamic acid, phenethyl alcohol and the like.

Examples of the pH adjuster include inorganic acids (hydrochloride, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citrate, sodium citrate, succinate, sodium succinate, etc.), and inorganic bases (potassium hydroxide, hydroxide). (Sodium, etc.), potassium carbonate, sodium hydrogencarbonate, carbon dioxide, organic bases (arginine triethanolamine, diisopropanolamine, triisopropanolamine, etc.) and the like.

Examples of the chelating agent include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetic acid salt (sodium salt (sodium edetate: Japanese Pharmacy, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, polyphosphoric acid. , Metaphosphoric acid and the like. Of these, sodium edetate is preferable.

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.

Examples of the irritation reducing agent include licorice extract and polyvinylpyrrolidone.

Examples of the colorant include pigment grade titanium oxide, zinc oxide, iron oxide, organic pigment, talc, sericite, mica, synthetic mica, chromium oxide, gunjo and the like.

In addition, powder may be blended to improve the feel and impart a make-up effect. Specifically, boron nitride, silica, alumina, aluminum hydroxide, metal soap, silicone powder, polymethylmethyl methacrylate. And so on.

[viscosity]
The viscosity (25 ° C.) of the external composition for skin of the present invention is not particularly limited as long as it is within the range of 1 to 500,000 mPa · s, but is preferably 2 to 500,000 mPa · s from the viewpoint of significantly exerting the effect of the present invention. s, more preferably 3 to 300,000 mPa · s, still more preferably 5 to 200,000 mPa · s. Mainly, a composition for external use on the skin having such a viscosity can be obtained by appropriately selecting the type and content of the thickener as an additive component.

In the present invention, the viscosity is measured by a single cylindrical rotational viscometer (Brookfield type viscometer) in accordance with the viscosity measuring method described in the 17th revised Japanese Pharmacopoeia general test method. In this application, RB-80H (Toki Sangyo) is used, and the selection of conditions such as rotor and rotation speed is based on the instruction manual of this machine, and the viscosity at 25 ° C is measured. A description of the single cylindrical rotational viscometer is given below. A single cylindrical rotational viscometer is a viscometer that measures the torque when a cylinder in a liquid is rotated at a constant angular velocity. The viscosity η of the liquid is calculated by the following formula by experimentally determining the device constant KB using the standard solution for calibration of the viscometer in advance.
η = KB × T / ω
η: Liquid viscosity (mPa · s)
KB: Device constant (rad / cm ³ )
ω: Angular velocity (rad / s)
T: Torque acting on the cylindrical surface ( ^10-7 Nm)

[PH]
The external composition for skin of the present invention usually has a liquid property of pH 2.0 to 9.0, but is preferably pH 3. From the viewpoint of low irritation to the skin and mucous membranes and good skin usability. It is 0 to 8.5, more preferably pH 4.0 to 8.0, still more preferably pH 4.5 to 7.5, and even more preferably pH 5.0 to 7.5.

[Angular frequency value of sol-gel transition point in dynamic viscoelasticity]
The angular frequency of the sol-gel transition point in the dynamic viscoelasticity of the external composition for skin of the present invention is a value of the angular frequency ω at which the storage elastic modulus G ′ and the loss elastic modulus G ″ show the same value, for example, a leometer. More specifically, MCR 102 (manufactured by Antonio Par) is used as a leometer, and PP25-SN31369 (d = 1 mm) is used as a measuring tool, and shaken at 25 ° C. The range of angular frequency (ω) = 100 to 0.1 (rad / s) was measured under the condition of angle (γ) = 1%.

The angular frequency (rad / s) of the sol-gel transition point of the external composition for skin of the present invention is preferably 3 or more, more preferably 4 or more, still more preferably 5 or more, from the viewpoint of significantly exerting the effect of the present invention. Is. The larger the angular frequency of the sol-gel transition point, the slower the restoration speed, the easier it is to exhibit the properties of a viscous body when a force is applied to the composition with a finger, etc., and the easier it is to scoop the composition during use. It stretches and fits well on the skin.

[How to improve usability]
The present invention also includes (A) a method for improving the usability of a composition for external use on the skin containing a hydrophobically modified polyether urethane. According to the present invention, a composition for external use on the skin containing one or more components selected from the group consisting of (A) hydrophobically modified polyether urethane; (B) nicotinic acid amide, vitamin C derivative, arbutin and tranexamic acids. By using the product, it is possible to achieve an improvement in the usability of the external composition for skin containing (A) hydrophobically modified polyether urethane. Here, the improvement of usability refers to, for example, improving the spread of the composition when the external composition for skin is applied to the skin, improving the familiarity with the skin, and the like.

[Manufacturing method of external composition for skin]
The method for producing the external composition for skin of the present invention is not particularly limited, and in addition to the above-mentioned components (A) to (C), the above-mentioned other components and the like are appropriately selected and blended, and emulsified as necessary by a conventional method. Can go and manufacture.

[Properties / Formulation]
The properties of the external composition for skin of the present invention are not particularly limited, and may be liquid, fluid, or semi-solid. Formulation forms include, for example, liquid preparations, suspensions, emulsions, creams, emulsions, ointments, gels, liniments, lotions, aerosols, non-woven fabrics impregnated with chemicals, sticks, and the like. It can be a formulation. Among them, emulsions, creams, emulsions, ointments, gels, lotions and sheets are preferable, and creams, emulsions, gels, lotions, sheets and sticks are particularly suitable. When an oily base and an aqueous base are contained, such as emulsions, creams, and ointments, either W / O type or O / W type may be used, but an appropriate increase in the external composition for skin of the present invention may be used. The O / W type is more preferable from the viewpoint of ensuring viscosity and the feeling of use (stickiness, spread, moist feeling, freshness, penetration feeling, etc.).

The external composition for skin of the present invention is not particularly limited, but from the viewpoint of significantly exerting the effect of the present invention, the preparation is preferably a homogeneous preparation containing no non-uniform particles such as gel particles.

[Use applications]
Specifically, when it is used as an external composition for pharmaceutical products or cosmetics, for example, lotion, milky lotion, gel, cream, beauty liquid, sunscreen cosmetic, pack, mask, hand cream, etc. All-in-one gel, all-in-one cream, wipe-off cosmetics, stick cosmetics, scalp cosmetics, mist, body lotion, and basic cosmetics such as body cream; as well as wash pigments, hand soaps, makeup removers, body shampoos, shampoos. , Rinsing, and cleaning cosmetics such as treatments, face makeup cosmetics such as BB cream, foundation, makeup base, lip cosmetics such as lip cream, lip liner, lip gel; hair rinsing, hair treatment for hair , Hair conditioners, hair gels, hair mousses, hair mists, hair lotions, hair cosmetics such as styling agents, etc. Of these, external compositions for the skin are particularly preferable. That is, the external composition of the present invention can be a pharmaceutical, quasi-drug, or cosmetic external composition for skin. The formulation form of the external composition for skin is the same as that of the external composition of the present invention. In addition, usable bases or carriers, additives, and active ingredients, and preferred embodiments thereof, are the same as in the case of the external composition of the present invention.

[container]
The external composition for skin of the present invention can be contained and used in a container having a shape and material appropriately selected according to the purpose of use and use. Specific examples of the container include a spray type, a bottle type, a tube type, a jar type, a spoid type, a dispenser type, a stick type, a pouch bag, and a cheer pack. The composition for external use on the skin of the present invention has the advantage that it can be smoothly applied, sprayed, etc. even if it is once gelled due to the physical properties of the hydrophobically modified polyether urethane, for example, a preparation containing a high concentration (B) component or a high concentration. Even in the case of highly viscous preparations such as preparations containing a concentration of hydrophobically modified polyether urethane, the degree of freedom in formulation design can be increased. That is, it can be easily used in a wide variety of containers such as sprays, bottles, tubes and dispensers as well as jars for various viscous preparations.

Further, as the material of the container, polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, metal (aluminum, etc.) and the like can be exemplified. In addition, these materials are subjected to various coating treatments in consideration of strength, flexibility, weather resistance, stability of components, etc., and these materials are combined or laminated by, for example, mixing them. , Can be used as a container material. Examples of the coating material include epoxy resin and polyamide-imide. Of these, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ethylene vinyl alcohol resin, or metal (aluminum, etc.) is preferably used.

[How to use]
The external composition for skin of the present invention is expected to have effects such as blood circulation promotion, anti-inflammatory, ceramide synthesis promotion, whitening, anti-wrinkle, anti-aging, etc. due to the physiological activity of the component (B), and can be used as a whitening agent, a sunscreen, etc. Including, it is useful as a multifunctional preparation. The external composition for skin of the present invention can be used in a known or commonly used dosage and administration in 1 to several divided doses per day depending on the intended use.

Next, the present invention will be specifically described with reference to Examples and Test Examples, but the present invention is not limited to the following Examples and Test Examples.

[Raw materials used]
The raw materials used in the following test examples and production examples are as follows. The numerical value in each table of the test example is the content of the component itself described in the component name (in each case, the unit is mass%). In addition, the numerical values in each table of the formulation examples are the blending amounts of the following raw material products themselves.
(PEG-240 / decyltetradeceth-20 / HDI) Copolymer: Adecanol GT700
Polyoxyethylene methylglucoside (10EO): Macbiobride MG-10E (manufactured by NOF CORPORATION)
Polyoxypropylene methylglucoside (10PO): Macbiobride MG-10P (manufactured by NOF CORPORATION)
Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3BO) (8EO) (5PO): WILBRIDE S-753 (manufactured by NOF CORPORATION)
Polyoxyethylene polyoxypropylene butyl ether (17EO) (17PO): Unilube 50MB-26 (manufactured by NOF CORPORATION)
2-Methylloyloxyethyl phosphorylcholine / butyl methacrylate copolymer: Lipidure PMB-RT (manufactured by NOF CORPORATION)
Cyclohexanedicarboxylic acid bisethoxydiglycol: Neosolue aqualio (manufactured by Nippon Fine Chemical Co., Ltd.)
(Icosanedioic acid / tetradecanedioic acid) Decaglyceryl: Neosolue-AquaS (manufactured by Nippon Fine Chemical Co., Ltd.)
Polyoxyethylene glyceryl ether (26EO): Blaunon GL-26 (manufactured by Aoki Oil & Fat Co., Ltd.)
Diethoxyethyl succinate: CRODAMOL DES-LQ (manufactured by Croda Japan Co., Ltd.)

[Test Example 1. Comparison of angular frequency values of sol-gel transition points of topical skin compositions 1]
Samples with the compositions shown in Table 1 below were prepared. Using this as a rheometer, MCR 102 (manufactured by Antonio Par), and PP25-SN31369 (d = 1 mm) as the measuring jig, the angular frequency (ω) was set at 25 ° C. and the swing angle (γ) = 1%. The range of = 100 to 0.1 (rad / s) was measured. The values of the angular frequency of the obtained sol-gel transition point and the results of judgment according to the following evaluation criteria are shown in the same Table 1. When the angular frequency value of the sol-gel transition point was less than 2.5 rad / s, the recovery rate of the preparation was high and the elongation and familiarity of the preparation were not good, so it was judged that the preparation was not suitable.
<Evaluation criteria for angular frequency at the sol-gel transition point>
× Angular frequency of sol-gel transition point (rad / s) less than 2.5 △ Angular frequency of sol-gel transition point (rad / s) 2.5 or more and less than 3 ○ Angular frequency of sol-gel transition point (rad / s) s) 3 or more and less than 6 ◎ Angular frequency (rad / s) of sol-gel transition point 6 or more

In addition, the appearance of the obtained preparation was observed, and the transparency of the preparation was judged according to the following judgment criteria. The higher the transparency of the formulation, the wider the range of applications to various containers and specifications. The evaluation results are shown in Table 1.
<Evaluation of formulation transparency>
× The preparation is turbid and the transparency is low. △ Slight turbidity is seen, but it is almost transparent. ○ It has a transparent appearance.

In the presence of the hydrophobically modified polyether urethane (PEG-240 / decyltetradeceth-20 / HDI) copolymer, in Comparative Examples 1-1 to 5 containing no nicotinamide, the angular frequency of the sol-gel transition point was 3 In contrast, in Examples 1-1 to 6 containing the hydrophobically modified polyether urethane and the nicotinamide, all of them showed a large value of 5 rad / s or more, and were tripled or more by the addition of the nicotinamide. There was an increase in the value of the angular frequency of. From the above, the value of the angular frequency of the sol-gel transition point increased in the coexistence of the component (A) and the component (B). All of the preparations of the examples were easy to scoop and had a good feeling of use (spreading and familiarity).

Further, when Comparative Examples 1-1, 3 and 4 and Examples 1-1, 3 and 4 are compared, the hydrophobically modified polyether urethane and the polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B. When O.) (8EO) (17PO) or polyoxyethylene polypropylene butyl ether (17EO) (17PO) is contained, the appearance of the preparation is further added by adding nicotinic acid amide. The effect of eliminating white turbidity was also seen.

[Test Example 2. Comparison of angular frequency values of sol-gel transition points of topical skin compositions 2]
The external composition for skin having the composition shown in Tables 2 to 6 below was prepared. Then, the same method evaluation as in Test Example 1 was performed. That is, the value of the angular frequency at the sol-gel transition point was measured, and the judgment was made according to the above evaluation criteria. In addition, the appearance of the obtained preparation was observed, and the transparency of the preparation was judged according to the above criteria. The results are shown in Tables 2-6.

Similar to Test Example 1, the preparations of Examples containing at least the components (A) and (B) have a sol-gel transition point angular frequency value of 2.5 rad / s or more, and have a feeling of use. (Expansion / familiarity) was good. Further, it was clarified that when nicotinamide was used as the component (B), a composition for external use on the skin having a particularly high angular frequency value at the sol-gel transition point could be obtained.

Further, as a result of measuring the angular frequency value of the sol-gel transition point after storing the external composition for skin of Examples in Tables 2 to 6 at 60 ° C. for 1 week, it was not significantly different from that before storage. Therefore, it was clarified that the effect of the present invention is stably maintained during storage.

[Formulation example]
Based on the formulations shown in Tables 7 to 45 below, the external composition for skin of the present invention (Formulation Examples 1 to 39) was prepared.

Claims (4)

A composition for external use on the skin containing one or more components selected from the group consisting of (A) hydrophobically modified polyether urethane and (B) nicotinamide, vitamin C derivative, arbutin and tranexamic acid. The composition for external use on the skin according to claim 1, wherein the component (A) is a hydrophobically modified polyether urethane represented by the following chemical formula (I).
R ¹ -{(OR ² ) _k- OCONH-R ³ [-NHCOO- (R ^4- O) _n- R ⁵ ] _h } _m (I)
(In the formula, R ¹ represents a hydrocarbon group, R ² and R ⁴ each independently represent an alkylene group having 2 to 4 carbon atoms, and R ³ may have a urethane bond, such as a straight chain, a branched chain or a branched chain. Represents a hydrocarbon group containing an aliphatic or aromatic ring, R ⁵ represents a hydrocarbon group having a branched chain; m is an integer of 2 or more, h is an integer of 1 or more, and k and n are respectively. It is an integer in the range of 0 to 1000 independently, and k + n ≧ 1). The external composition for skin according to claim 1 or 2, further comprising (C) one or more components selected from the group consisting of phenoxyethanol, dipropylene glycol and amphipathic components. The amphoteric component of the component (C) is a 2-methacryloyloxyethyl phosphorylcholine-containing polymer, a divalent carboxylic acid ester, an alkanediol having 5 to 10 carbon atoms, and an alkylene oxide derivative represented by the following chemical formula (II). The composition for external skin according to any one of claims 1 to 3, which is one or more selected from the group consisting of:
Z- [O- (AO) _a (EO) _b- (BO) _c- H] _n (II)
(N in the formula is an integer from 1 to 9;
Z is a group obtained by removing n hydroxy groups from a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms;
AO is an oxyalkylene group having 3-4 carbon atoms;
EO is an oxyethylene group;
BO is an oxyalkylene group having 4 carbon atoms;
a, b, and c are the average number of moles of AO, EO, and BO, respectively, which are 0 to 200 independently; a, b, and c are not all 0;
AO and EO may be added randomly or in blocks;
When n is 2 or more, the plurality of a, b, and c may be the same or different.
If Z is a hydrogen atom, n is 1).