JP2023178448A - Skin external composition - Google Patents

Abstract

To provide a skin external composition which suppresses a decrease in viscosity with time, caused by high concentrations of nicotinic acid amide and water-soluble polysaccharides.SOLUTION: There is provided a skin external composition which comprises (A) water-soluble polysaccharides, (B) 3 mass% or more of nicotinic acid amide and (C) an amphipathic component.SELECTED DRAWING: None

Description

The present invention relates to a skin external composition containing a water-soluble polysaccharide, nicotinic acid amide, and an amphipathic component.

Nicotinic acid amide is a type of vitamin that has been used in the skin care field to promote blood circulation, anti-inflammation, and promote ceramide synthesis. It is also known to have beneficial effects.

For example, Patent Document 1 proposes a whitening agent containing as an active ingredient one or more selected from the group consisting of riboflavin, pyridoxine hydrochloride, nicotinamide, and calcium pantothenate.

On the other hand, water-soluble polysaccharides are incorporated into external skin compositions to impart functions such as thickening and moisturizing.

For example, Patent Document 2 proposes a cosmetic containing a fine gel-like composition obtained by pulverizing a gel containing gellan gum, which is a water-soluble polysaccharide, and 4-methoxysalicylate.

Japanese Patent Application Publication No. 2004-217629 Japanese Patent Application Publication No. 2008-230994

In order to effectively exhibit the various efficacies of nicotinic acid amide, formulations containing nicotinic acid amide at high concentrations have been developed. However, the present inventors have discovered that water-soluble polysaccharides and 3
A new problem was discovered in that when more than % by mass of nicotinic acid amide coexists, the viscosity decreases over time.

Therefore, an object of the present invention is to provide a composition for external use on the skin in which a decrease in viscosity is suppressed even when a water-soluble polysaccharide and 3% by mass or more of nicotinic acid amide are used together.

As a result of extensive studies, the present inventors have found that by containing (C) an amphiphilic component in addition to (A) a water-soluble polysaccharide, (B) 3% by mass or more of nicotinic acid amide, a composition for external use on the skin can be obtained. The inventors have discovered that it is possible to suppress the decrease in viscosity of substances over time, and have completed the present invention.

That is, the present invention provides the following composition for external use on the skin.
Item 1.
A skin external composition containing (A) a water-soluble polysaccharide, (B) 3% by mass or more of nicotinic acid amide, and (C) an amphipathic component.
Item 2.
Item 2. The skin external composition according to Item 1, wherein the content of the component (B) is 3 to 20% by mass.
Item 3.
The component (C) is one or more selected from the group consisting of a phosphorylcholine-containing polymer, a divalent carboxylic acid ester, an alkanediol having 5 to 10 carbon atoms, and an alkylene oxide derivative represented by the following chemical formula (I). The skin external composition according to item 1 or 2, which is:
Z-{O(AO)a(EO)b-(BO)cH}n (I)
(In the formula, n is an integer from 1 to 9;
Z is a hydrogen atom or a group obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms;
AO is an oxyalkylene group having 3 to 4 carbon atoms;
EO is an oxyethylene group;
BO is an oxyalkylene group having 4 carbon atoms;
a, b, and c are the average number of added moles of AO, EO, and BO, respectively, and are each independently from 0 to 200; a, b, and c are never all 0;
AO and EO may be added randomly or in blocks;
When n is 2 or more, a, b, and c may be the same or different;
When Z is a hydrogen atom, n is 1).
Item 4.
Any one of claims 1 to 3, wherein the component (A) is one or more selected from the group consisting of gums, heparin-like substances, alginic acids, agar, pectin, pullulan, and mannan. The skin external composition described in .
Item 5.
In the chemical formula (I), Z is a hydrogen atom, or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, trimethylolpropane, erythritol, pentaerythritol, alkyl glucoside, diglycerin, xylitol, dipentaerythritol, sorbitol, Inositol, sucrose, trehalose, maltitol, or 1 carbon number
Item 5. The composition for external use on skin according to item 3 or 4, which is a group obtained by removing n hydroxy groups from a hydroxy compound of 30 to 30.

ADVANTAGE OF THE INVENTION According to the present invention, it is possible to provide a composition for external use on the skin containing a high concentration of nicotinic acid amide, in which a decrease in viscosity over time is suppressed.

In the present invention, suppressing the decrease in viscosity over time includes not only reducing the degree of decrease in viscosity caused by containing nicotinic acid amide but also increasing the viscosity over time.

In the present invention, the decrease in viscosity over time includes, but is not particularly limited to, a decrease in viscosity over time due to, for example, heat, irradiation with visible light or ultraviolet light, or the like.

In this specification, the unit of content "mass%" has the same meaning as "g/100g".

The skin external composition of the present invention contains (A) a water-soluble polysaccharide, (B) 3% by mass or more of nicotinic acid amide, and (C) an amphipathic component.

[(A) Water-soluble polysaccharide]
The water-soluble polysaccharide contained in the skin external composition as component (A) of the present invention may be a naturally derived substance or a substance obtained by chemical synthesis.

Examples of water-soluble polysaccharides include gums (gellan gum, xanthan gum, sclerotium gum, locust bean gum, biosaccharide gum, tamarind gum, quince seed, gum arabic, carrageenan, tara gum, guar gum, galactan, gum arabic,
Gum tragacanth, curdlan, succinoglucan, etc.); carrageenan; heparin-like substances; alginic acids (alginic acid, sodium alginate, propylene glycol alginate, etc.); agar (including agarose); pectin; pullulan; mannan, etc.

As component (A) of the present invention, any of these compounds can be used alone or in combination of two or more, and among them, gums, heparin-like substances, alginic acids, agar,
One or more selected from the group consisting of pectin, pullulan, and mannan are preferred, including gellan gum, xanthan gum, sclerotium gum, gum arabic, tamarind seed gum, biosaccharide gum, carrageenan, heparin-like substances, alginic acids, agar,
More preferably, one or more selected from the group consisting of pectin and pullulan, and more preferably selected from the group consisting of gellan gum, xanthan gum, sclerotium gum, carrageenan, heparin analogs, alginic acids, agar, pectin, and pullulan. One or more types are more preferable, and one or more types selected from the group consisting of gellan gum, xanthan gum, heparin-like substances, alginic acids, agar, and pectin are even more preferable, and gellan gum, xanthan gum, heparin-like substances, and one or two selected from the group consisting of agar.
Particularly preferred are species or more.

Gellan gum is derived from Pseudomonas elodea.
A) is produced by aerobic fermentation using glucose or the like as a carbon source, and has glucose, glucuronic acid, and rhamnose as constituent sugars. When gellan gum is produced by fermentation, the 1-
An acetyl group and a glyceryl group are present in the 3-bonded glucose. Native type gellan gum is recovered and manufactured into a product, and deacylated gellan gum is obtained by removing acyl groups (acetyl groups and glyceryl groups) from this native type gellan gum. The type of gellan gum used in the present invention is not particularly limited, but native gellan gum is more preferred. In addition, the viscosity average molecular weight of gellan gum is 10,000 to 5 million, preferably 1
00,000 to 1,000,000, more preferably 300,000 to 700,000.
The skin external composition of the present invention may be a commercially available product, and is not particularly limited, but for example, KE
LCOGEL CG-LA, KELCOGEL CG-HA, KELCOGEL HM, KELCOGEL DGA (manufactured by CP Kelco U.S.), etc. can be used.

Xanthan gum is produced by fermentation of Xanthomonas bacteria using hydrocarbons as a carbon source, and has constituent sugars such as glucose, mannose, and glucuronic acid. Commercially available products may be used for the skin external composition of the present invention, and examples include, but are not limited to, KELTROL CG, KELTROL
ROL CG-T, KELTROL CG-SFT, KELTROL T (CPKelc
(manufactured by Sumitomo Dainippon Pharma Co., Ltd.), Nomcoat ZZ (manufactured by Nisshin Oilio Co., Ltd.), Echo Gum T (manufactured by Sumitomo Dainippon Pharma Co., Ltd.)
Co., Ltd.) etc. can be used.

Sclerotium gum is an encapsulated β-D-glucan produced from fungal species grown in a medium containing glucose or sucrose as a carbon source and a complex nitrogen source with the addition of inorganic salts. Although not particularly limited, for example, glucan with an estimated degree of polymerization of about 100 is Sc
Glucan obtained from lerotium glucanicum and having a degree of polymerization of about 800 is obtained from the strain Sclerotium rolfsii. In addition to the degree of polymerization, the various sclerotium gums differ slightly in the number and length of side chains. Commercially available products may be used for the skin external composition of the present invention, and are not particularly limited. For example, AMIGEL (Alban Mule
(manufactured by R company) can be used.

Gum arabic is obtained from the sap of a plant belonging to the genus Acacia, which is a legume, and is an acidic polysaccharide whose constituent sugars are galactose, L-arabinose, L-rhamnose, and glucuronic acid. Commercially available products may be used for the skin external composition of the present invention, and for example, Arabic Call SS (manufactured by Sanei Yakuhin Trading Co., Ltd.) can be used, but is not limited thereto.

Tamarind seed gum is a xyloglucan whose main chain is glucose and the side chain is xylose. Commercially available products may be used for the skin external composition of the present invention, and there are no particular limitations, such as Glyloid 6C (manufactured by Dainippon Pharmaceutical Co., Ltd.).

Biosaccharide gums are known as biosaccharide gums-1, 2, 3, and 4, all of which are obtained by fermentation from sorbitol, but the production method is not particularly limited. Biosaccharide gum-1 is a polysaccharide in which L-fucose, D-galactose, and D-galacturonic acid are sequentially bonded. Biosaccharide gum-2 is a polysaccharide whose main component is rhamnose.
α-L-Rhap(1→3)-β-D-Galp-(1→2)-α-LRhap-(1→4)-β-D-GlepA(1→3)-[α-L-Rhap -(1
→2)-]-α-D-Galp-(1) Biosaccharide gum-3 is a polymer of L-fucose, D
- It is a polysaccharide in which galactose and D-galacturonic acid are continuously bonded, but it has a lower degree of polymerization and molecular weight than biosaccharide gum-1. Biosaccharide gum-4 is a deacetylated branched polysaccharide with repeating units of L-fucose, 2-D-glucose, and glucuronic acid. Among them, biosaccharide gum-1 is preferably used in the skin external composition of the present invention. Commercially available products may be used for the skin external composition of the present invention, and examples thereof include, but are not limited to, FUCOGEL 1.5P, which is biosaccharide gum-1, FUCOGEL
1000 PP; Rhamnosoft HP 1.5P which is biosaccharide gum-2
Glicofilm 1.5P (both manufactured by Solabia, France), which is biosaccharide gum-4, can be used.

Carrageenan is a natural polymer extracted and purified from red algae. The main chain of carrageenan is composed of galactose, and it is broadly classified into kappa-type carrageenan, iota-type carrageenan, and lambda-type carrageenan, depending on the position and number of bonded sulfate groups and the presence or absence of an anhydro structure. The type of carrageenan used in the present invention is not particularly limited, but a preferred carrageenan is kappa-type carrageenan. The skin external composition of the present invention contains GE
NUVISCO type PJ-JPE (manufactured by CP Kelco), Soagina MV1
01, Soagina MV201, Soagina MV320M (manufactured by MRC Polysaccharide Co., Ltd.), etc. can be used.

Heparin-like substances are polysulfated mucopolysaccharides such as polysulfated chondroitin. It is preferable that each monosaccharide molecule constituting the mucopolysaccharide has an average of 0.5 to 5 molecules, particularly an average of 0.6 to 3 molecules of sulfate groups. Heparin-like substances include, for example, heparin and polysulfated chondroitin such as chondroitin sulfate D and chondroitin sulfate E. Among these, heparin-like substances that are included in the non-Japanese Pharmacopoeia drug standards can be suitably used.

Pectin is a polysaccharide whose constituent sugars are rhamnose and galacturonic acid, and a portion of the main chain of galacturonic acid is esterified with a methyl group or an acetyl group. The molar content (%) of methyl esterified galacturonic acid is defined as the degree of methyl esterification (DE), and DE is 50%.
The above pectins are called high methoxyl (HM) pectins, and those with a DE of less than 50% are called low methoxyl (LM) pectins. The skin external composition of the present invention contains HM pectin and L.
Any of the M pectins may be used. Commercially available products include, but are not particularly limited to, G
ENU pectin LM-104AS-J, GENU pectin USP-H (
(manufactured by CP Kelco) etc. can be used.

Agar is a polysaccharide obtained from the mucilage of red algae, such as Amanita spp. The composition for external use on the skin of the present invention is not particularly limited to the degree of polymerization or molecular weight of agarose or agaropectin, the content of sulfate groups and pyruvic acid groups in agar, etc.
Any one may be used, and there are no particular limitations on commercially available products, such as agar AX-
30, UP-6, UP-37CS, Ultra Agar UX-30, UX-200 (manufactured by Ina Food Industry Co., Ltd.), etc. can be used.

Pullulan is a product in which maltotriose, which consists of three glucose units formed by α-1,4 glucosidic bonds, is repeatedly linked in a chain by α-1,6 glucosidic bonds. Commercially available products may be used in the skin external composition of the present invention, and examples thereof include, but are not limited to, PU101 and pullulan for cosmetics (manufactured by Hayashibara Co., Ltd.).

Alginic acids are alginic acid in which two types of uronic acids, mannuronic acid and guluronic acid, are linked in a linear chain, salts of alginic acid, and derivatives of alginic acid such as propylene glycol alginate. Examples of the salt include sodium salts and potassium salts, and among them, sodium salts are preferred. Commercially available products may be used for the skin external composition of the present invention, and examples thereof include, but are not limited to, Duck Algin NSPM-R (manufactured by Kikkoman Biochemifa Co., Ltd.) and Kimica Algin IL-2 (manufactured by Kimica Co., Ltd.). , Duck Algin NSPH2R, Duckroid FF-50-M (manufactured by Kikkoman Biochemifa Co., Ltd.), Sodium Alginate HG,
Sodium alginate SHG (manufactured by Maikono Kohara Co., Ltd.), etc. can be used.

The total content of component (A) is not particularly limited and may be appropriately set depending on the type of water-soluble polysaccharide, the type of other ingredients, etc. From the viewpoint of increasing the stability of the composition, preferably 0.005% by mass or more, more preferably 0.01% by mass or more, still more preferably 0.05% by mass or more, even more preferably is 0
．． It is 1% by mass or more.
The total content of component (A) is preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass, based on the total amount of the skin external composition, from the viewpoint of improving the feeling of use. The content is further preferably 1.5% by mass or less, particularly preferably 1.2% by mass or less.
The total content of component (A) is preferably 0.005 to 5% by mass, more preferably 0.01 to 3% by mass, and even more preferably 0.05 to 2% by mass, based on the total amount of the skin external composition. , even more preferably 0.1 to 1.5% by mass.

Among component (A), the total content of gums is not particularly limited, and is preferably 0.005 to 5% by mass, more preferably 0.01 to 3% by mass, based on the total amount of the skin external composition. More preferably 0.01 to 2% by weight, even more preferably 0.05 to 1% by weight, particularly preferably 0.01% to 2% by weight.
It is 1 to 0.3% by mass.
Among the components (A), the content of agar is not particularly limited, and is based on the total amount of the skin external composition.
Preferably 0.01 to 3% by mass, more preferably 0.05 to 2% by mass, even more preferably,
It is 0.1 to 1.5% by mass.

Among component (A), the content of the heparin-like substance is not particularly limited, and is preferably 0.005 to 5% by mass, more preferably 0.01 to 3% by mass, based on the total amount of the skin external composition. More preferably, it is 0.05 to 1% by weight, even more preferably 0.1 to 0.5% by weight, particularly preferably 0.1 to 0.3% by weight.

[(B) Nicotinic acid amide]
Nicotinic acid amide contained in the skin external composition as component (B) of the present invention is an amide compound of nicotinic acid (vitamin B3/niacin), and is a water-soluble vitamin. Nicotinic acid may be an extract from a natural product or may be one synthesized by a known method.
Specifically, those listed in the 17th edition of the Japanese Pharmacopoeia can be used. In addition to promoting blood circulation and improving rough skin, it is also known to suppress melanin production and whiten skin.

In the skin external composition of the present invention, the content of component (B) relative to the total amount of the skin external composition is appropriately set depending on the balance with other components. The content of component (B) is 3% by mass or more based on the total amount of the skin external composition, from the viewpoint of significantly exhibiting the effects of the present invention and sufficiently imparting efficacy such as whitening and anti-aging, Preferably 4% by mass or more, more preferably 5% by mass
It can also be greater than % by mass.
The content of component (B) is preferably 20% by mass or less, more preferably 15% by mass or less, even more preferably It is 10% by mass or less, even more preferably 8% by mass or less.
The content of component (B) is preferably 3 to 20% by mass, based on the total amount of the skin external composition.
More preferably 3 to 15% by weight, still more preferably 3 to 10% by weight, even more preferably 3 to 8% by weight.

The total content of component (B) per 1 part by mass of component (A) in the skin external composition of the present invention is not particularly limited, but from the viewpoint of significantly achieving the effects of the present invention, it is preferably 0. .5
~10000 parts by mass, more preferably 1 to 8000 parts by mass, even more preferably 2 to 5000 parts by mass
Parts by weight, even more preferably 2 to 1000 parts by weight.

[(C) Amphipathic component]
The amphipathic component contained in the skin external composition as component (C) of the present invention has both a hydrophilic group and a hydrophobic group (lipophilic group) in one molecule, resulting in an aqueous phase and an oil phase ( Refers to all compounds that have an affinity for any organic phase (organic phase).

Examples of such amphipathic components include, but are not limited to, alkylene oxide derivatives, phosphorylcholine-containing polymers, dihydric carboxylic acid esters, alkanediols having 5 to 10 carbon atoms, and the like. As component (C) of the present invention, any of these compounds may be used alone or in combination of two or more. Among them, component (C) of the present invention is preferably an alkylene oxide derivative represented by the following general formula (I), a 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer, from the viewpoint of significantly exhibiting the effects of the present invention. 1 selected from the group consisting of decaglyceryl (eicosanedioic acid/tetradecanedioic acid), bisethoxydiglycol cyclohexanedicarboxylate, diethylhexyl succinate, diethoxyethyl succinate, and alkanediol having 5 to 10 carbon atoms. species or two or more species.

The alkylene oxide derivative used in the present invention is represented by the following formula (I).

Z-{O(AO)a(EO)b-(BO)cH}n (I)
(In the formula, n is an integer from 1 to 9;
Z is a hydrogen atom or a group obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms;
AO is an oxyalkylene group having 3 to 4 carbon atoms;
EO is an oxyethylene group;
BO is an oxyalkylene group having 4 carbon atoms;
a, b, and c are the average number of added moles of AO, EO, and BO, respectively, and are each independently from 0 to 200; a, b, and c are never all 0;
AO and EO may be added randomly or in blocks;
When n is 2 or more, a, b, and c may be the same or different;
When Z is a hydrogen atom, n is 1).

In chemical formula (I), Z is preferably a hydrogen atom, or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, trimethylolpropane, erythritol, pentaerythritol, or an alkyl glucoside, from the viewpoint of significantly achieving the effects of the present invention. , diglycerin,
It is a group obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms such as xylitol, dipentaerythritol, sorbitol, inositol, sucrose, trehalose, and maltitol. Z is more preferably a hydrogen atom, or an alkyl monoalcohol having 4 to 24 carbon atoms, an alkyl glucoside, glycerin, diglycerin, erythritol, xylitol, dipentaerythritol, pentaerythritol,
A group obtained by removing n hydroxy groups from trimethylolpropane or sorbitol, more preferably a hydrogen atom or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, diglycerin, alkyl glucoside, penta A group obtained by removing n hydroxy groups from erythritol, trimethylolpropane or sorbitol, and even more preferably an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, diglycerin, alkyl glucoside, pentaerythritol or A group obtained by removing n hydroxy groups from sorbitol, particularly preferably a group obtained by removing n hydroxy groups from an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin or diglycerin. It is.

AO in the chemical formula (I) is an oxyalkylene group having 3 to 4 carbon atoms, and examples include oxypropylene group, oxybutylene group (oxy n-butylene group, oxyisobutylene group, oxy t-butylene group), oxytrimethylene group. group, oxytetramethylene group, and the like. A
O is preferably an oxypropylene group, an oxybutylene group, and more preferably an oxypropylene group.
BO is an oxyalkylene group having 4 carbon atoms, such as an oxybutylene group (oxyn
-butylene group, oxyisobutylene group, oxyt-butylene group), oxytetramethylene group, etc. BO is preferably an oxybutylene group.

In chemical formula (I), when Z is an alkyl monoalcohol having 4 to 24 carbon atoms, an alkyl monoalcohol having 4 to 22 carbon atoms is particularly preferable, and an alkyl monoalcohol having 4 to 16 carbon atoms is preferable, from the viewpoint of exhibiting the effects of the present invention significantly. More preferred are alkyl monoalcohols having 4 to 10 carbon atoms, and even more preferred are alkyl monoalcohols having 4 to 10 carbon atoms.

In the alkylene oxide derivative used in the present invention, a, b, and c each independently range from 0 to 200. a, b, c are each independently preferably 1 to 200, more preferably 2 to 150, still more preferably 2 to 100, and even more preferably 2 to 70. .

In chemical formula (I), it is the total number of monomer units of AO, EO, and BO (a+b+
c)×n is preferably 3 or more, more preferably 5 or more, and even more preferably 10 or more, from the viewpoint of significantly achieving the effects of the present invention, and (a+b+c)×n From the viewpoint of outstanding performance, it is preferably 450 or less, more preferably 350 or less, still more preferably 300 or less, and even more preferably 250 or less.

The molecular weight of the alkylene oxide derivative used in the present invention is preferably 200 or more, more preferably 300 or more, and still more preferably 400 or more, from the viewpoint of significantly achieving the effects of the present invention.

The property of the alkylene oxide derivative is not particularly limited as long as it exhibits the effects of the present invention, but in formula (I), it is preferably semi-solid (paste-like) at 25°C from the viewpoint of significantly achieving the effects of the present invention. ) to liquid components are preferred.

In addition, such alkylene oxide derivatives include polyoxyalkylene glyceryl ether, polyoxyalkylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene oxybutylene alkyl ether, polyoxy Alkylene sorbitol, polyoxyalkylene erythritol ether, polyoxyalkylene pentaerythritol ether, polyoxyalkylene diglyceryl ether, polyoxyalkylene trimethylol propane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyalkylene xylitol, polyoxy Examples include alkylene dipentaerythritol, polyoxyalkylene inositol, polyoxyalkylene sucrose ether, polyoxyalkylene trehalose ether, and polyoxyalkylene maltitol ether.
Among them, polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene Polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbitol,
Polyoxyethylene sorbitol, polyoxyethylene polyoxypropylene sorbitol,
Polyoxypropylene erythritol ether, polyoxyethylene erythritol ether, polyoxyethylene pentaerythritol ether, polyoxyethylene polyoxypropylene erythritol ether, polyoxypropylene pentaerythritol ether, polyoxybutylene polyoxyethylene pentaerythritol ether, polyoxyethylene polyoxy Propylene pentaerythritol ether, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene diglyceryl ether, polyoxyethylene trimethylol propane, poly Oxypropylene trimethylolpropane, polyoxyethylene polyoxypropylene trimethylolpropane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxybutylene polyoxyethylene polyoxypropylene glycol, polyoxyethylene xylitol, polyoxypropylene xylitol, Polyoxyethylene polyoxypropylene xylitol, polyoxyethylene polyoxypropylene dipentaerythritol, polyoxyethylene dipentaerythritol,
Polyoxypropylene dipentaerythritol, polyoxyethylene inositol, polyoxypropylene inositol, polyoxyethylene polyoxypropylene inositol,
Polyoxyethylene sucrose ether, polyoxypropylene sucrose ether, polyoxyethylene polyoxypropylene sucrose ether, polyoxyethylene trehalose ether, polyoxypropylene rehalose ether, polyoxyethylene polyoxypropylene rehalose ether, polyoxyethylene maltitol ether, One or more selected from the group consisting of oxypropylene maltitol ether and polyoxyethylene polyoxypropylene maltitol ether,
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether,
Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether , polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbitol, polyoxyethylene sorbitol, polyoxyethylene polyoxypropylene sorbitol, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxypropylene pentaerythritol ether, polyoxyethylene pentaerythritol Ether, polyoxybutylene polyoxyethylene pentaerythritol ether, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene diglyceryl ether, poly Oxyethylene polyoxypropylene trimethylolpropane, polyoxypropylene glycol,
More preferably, one or more selected from the group consisting of polyoxyethylene polyoxypropylene glycol and polyoxybutylene polyoxyethylene polyoxypropylene glycol,
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether,
Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene alkyl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxy Ethylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxypropylene sorbitol, polyoxyethylene polyoxypropylene sorbitol, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxybutylene polyoxyethylene pentaerythritol ether, polyoxyethylene diglyceryl ether, Polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene diglyceryl ether, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene More preferably, one or more selected from the group consisting of polyoxypropylene glycol,
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether,
Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxyethylene diglyceryl ether, polyoxypropylene di Even more preferred is one or more selected from the group consisting of glyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether, and polyoxybutylene polyoxyethylene polyoxypropylene diglyceryl ether.

Such alkylene oxide derivatives are commercially available products, including, but not limited to, Unilube 50MB-26 (polyoxyethylene polyoxypropylene butyl ether (17E.O.) (17P.O.)), Unilube 50MB-168 ( Polyoxyethylene polyoxypropylene butyl ether (37E.O.) (38P.O.)), UNILUBE 50MB-11 (polyoxyethylene polyoxypropylene butyl ether (9E.O.)
．． ) (10P.O.)), Unisafe 10P-8 (polyoxyethylene polyoxypropylene cetyl ether (10E.O.) (8P.O.)), Unilube MT-630B (polyoxyethylene polyoxypropylene decyl tetradecyl Ether (30E.O.) (
6P. O. )), UNILUBE MS-70K (polyoxypropylene stearyl ether (
15P. O. )) Uniol HS-1600D (polyoxyalkylene sorbitol), Pronone #208 (polyoxyethylene polyoxypropylene glycol (150 E.O.
) (35P.O.)), Pronone #124P (polyoxyethylene (20) polyoxypropylene (20) glycol), Uniol D-2000 (polypropylene glycol)
, Macbiobride MG-10E (polyoxyethylene methyl glucoside (10E.O.
)), Macbiobride MG-20E (polyoxyethylene methyl glucoside (20E.
O. )), Macbiobride MG-10P (polyoxypropylene methyl glucoside (1
0P. O. ), Macbiobride MG-20P (polyoxypropylene methyl glucoside (20P.O.)), Wilbride MG2070 (polyoxybutylene polyoxyethylene polyoxypropylene methyl glucoside), Unilube 5TP-300KB (polyoxyethylene polyoxy Propylene pentaerythritol ether (5E.O.) (65
P. O. )); UNILUBE 50TG-32 (polyoxyethylene polyoxypropylene glyceryl ether (24E.O.) (24P.O.)), Wilbride S-753 (polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.
O. ) (8E.O.) (5P.O.)), Uniox G-1200 (polyoxyethylene glycerin), Unilube DGP-700 (polyoxypropylene diglyceryl ether), Unilube DGP-950 (polyoxypropylene diglyceryl ether) (manufactured by NOF Corporation); SY-DP14 (polyoxypropylene diglyceryl ether),
SY-DP9 (polyoxypropylene diglyceryl ether) (manufactured by Sakamoto Pharmaceutical Co., Ltd.); Newport GP-1000 (PPG-16 glyceryl ether), Newport SP-750 (polyoxyalkylene sorbitol ether), Newport PE-
68 (Polyoxyethylene polyoxypropylene glycol (160E.O.) (30P
．． O. )), Newport PE-78 (polyoxyethylene polyoxypropylene glycol (150E.O.) (35P.O.)), Newport GEP-2800 (polyoxyethylene polyoxypropylene glyceryl ether (24E.O.)) (24 P.O.)
) (manufactured by Sanyo Kasei Co., Ltd.); Emulgen PP-290 (polyoxyethylene polyoxypropylene glycol (160E.O.) (30P.O.), manufactured by Kao Corporation); N
IKKOL SG-G2424 (polyoxyethylene polyoxypropylene glyceryl ether (24E.O.) (24P.O.), NIKKOL SG-DTD630 (polyoxyethylene polyoxypropylene decyl tetradecyl ether (30E.O.) (6P)
．． O. )) (all manufactured by Nikko Chemicals); GLUCAM P-10 (polyoxypropylene methyl glucoside (10P.O.)), GLUCAM P-20 (polyoxypropylene methyl glucoside (20P.O.)) (all manufactured by Lubrizol) It is commercially available under names such as (manufactured by).
Commercially available alkylene oxide derivatives include:
Unilube 50MB-26, Unilube 50MB-168, Unior HS-1600D
, Pronon #208, Pronon #124P, Unior D-2000, Macbiobride MG-10E, Macbiobride MG-20E, Macbiobride MG-10P, Macbiobride MG-20P, Wilbride MG2070, Unilube 5TP-300KB
, Unilube 50TG-32, Wilbride S-753, Uniox G-1200,
UNILUBE DGP-700, UNILUBE DGP-950, SY-DP14, SY-DP9
, Newport GP-1000, Newport SP-750, Newport PE-68,
Newport PE-78, Newport GEP-2800, NIKKOL SG-G24
24, and Emulgen PP-290, preferably one or more selected from the group consisting of
Wilbride S-753, Unior HS-1600D, Pronon #208, Pronon #124P, Unior D-2000, MacBioBride MG-10E, MacBioBride MG-20E, MacBioBride MG-10P, MacBioBride MG- 20P, Wilbride MG2070, Uniox G-1200, Unilube 50TG-32, Unilube DGP-700, Unilube DGP-950, SY-DP14, SY-DP9,
Nieuport GP-1000, Nieuport SP-750, Nieuport PE-68, Nieuport PE-78, Nieuport GEP-2800, NIKKOL SG-G242
4, and Emulgen PP-290, one or more selected from the group consisting of
Wilbride S-753, MacBioBride MG-20P, and MacBioBride M
G-10P, Unilube DGP-700, Unilube DGP-950, SY-DP14,
More preferably, one or more selected from the group consisting of SY-DP9,
Wilbride S-753, Unilube DGP-700, Unilube DGP-950,
It is even more preferable to use one or more selected from the group consisting of SY-DP14 and SY-DP9.

In the present invention, one type of alkylene oxide derivative may be used alone, or two or more types may be used in any combination.

The phosphorylcholine-containing polymer refers to all polymers containing an organic compound containing phosphorylcholine as a monomer. Although not particularly limited, a methacroyloxyphosphorylcholine-containing polymer, which is a polymer obtained by polymerizing a monomer containing 2-methacryloyloxyethylphosphorylcholine, is particularly preferred from the viewpoint of significantly exhibiting the effects of the present invention. Among these, one or more selected from the group consisting of 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer (polyquaternium-51) and polymethacryloyloxyethylphosphorylcholine are preferred, and 2-methacryloyloxyethylphosphorylcholine/methacrylate Acid butyl copolymers are more preferred. Commercially available phosphorylcholine-containing polymers include Lipidure-PMB (2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer liquid, Polyquaternium-51).
, and Lipidure-HM (polymethacryloyloxyethylphosphorylcholine) (
Preferably, one or two or more selected from the group consisting of Lipi
dure-PMB (2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer liquid) is more preferred.

A divalent carboxylic acid ester is a compound condensed with a divalent carboxylic acid and a hydroxy group such as glycol or glycol ether, and examples thereof include, but are not limited to, polyglyceryl-10 (eicosanedioic acid/tetradecanedioic acid), cyclohexanedicarboxylic acid, etc. acid bisethoxydiglycol, 1,4-cyclohexanedicarboxylic acid bis(triethylene glycol monoethyl ether), adipate bis(diethylene glycol monoethyl ether), adipate bis(triethylene glycol monoethyl ether), and succinic acid diethoxy Ethyl, diethylhexyl succinate, among others, one selected from the group consisting of (eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10, bisethoxydiglycol cyclohexanedicarboxylate, diethoxyethyl succinate, and diethylhexyl succinate. One species or two or more species are preferred, and one or two or more species selected from the group consisting of diethoxyethyl succinate, eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10, and bisethoxydiglycol cyclohexanedicarboxylate are more preferred. More preferred are diethoxyethyl succinate and bisethoxydiglycol cyclohexanedicarboxylate.
In addition, commercially available products include, but are not limited to, diethoxyethyl succinate (CRODA).
MOL DES), diethylhexyl succinate (CRODAMOL OSU) (both manufactured by Croda Japan Co., Ltd.), Neosolue-Aqua, Neosolue-Aqu
aS ((eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10), Neosolu
e-Aqulio (bisethoxydiglycol cyclohexanedicarboxylate) (both manufactured by Nippon Fine Chemical Co., Ltd.) can be used.

From the viewpoint of exhibiting the effects of the present invention, the alkanediol preferably has 5 carbon atoms.
~10, more preferably 5-8, still more preferably 5-6. For example, one or more selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol are preferable, and 1,2-pentanediol and 1,2-hexane One or more diols selected from the group consisting of diols are more preferred, and 1,2-pentanediol is even more preferred. In addition, commercially available products include, but are not limited to, HYDROLIT
E-5, HYDROLITE-5 Green (manufactured by Symrise Co., Ltd.), KMO-6 (manufactured by Osaka Organic Chemical Industry), Microcare Emollient PTGJ, Microcare Em
olient HXD (manufactured by THOR) etc. can be used.

In the present invention, as component (C), in addition to the above-mentioned alkylene oxide derivatives, 2-
Methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer, polymethacryloyloxyethylphosphorylcholine, (eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10, bisethoxydiglycol cyclohexanedicarboxylate, diethylhexyl succinate, diethoxyethyl succinate, and alkanediols having 5 to 10 carbon atoms are preferred, and in addition to the above alkylene oxide derivatives, 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer, polymethacryloyloxyethyl Phosphorylcholine, (eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10, cyclohexanedicarboxylic acid bisethoxydiglycol,
Diethoxyethyl succinate, diethylhexyl succinate, 1,2-pentanediol, 1
, 2-hexanediol, and 1,2-octanediol are more preferred, and in addition to the above alkylene oxide derivatives, 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer is preferred. , polymethacryloyloxyethylphosphorylcholine, (eicosanedioic acid/tetradecanedioic acid) polyglyceryl-
10, one or more selected from the group consisting of bisethoxydiglycol cyclohexanedicarboxylate, diethoxyethyl succinate, 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol More preferably, in addition to the above alkylene oxide derivatives, 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer, bisethoxydiglycol cyclohexanedicarboxylate, diethoxyethyl succinate, 1,2-pentanediol, and 1,2 Even more preferred is one or more selected from the group consisting of -hexanediol. The above component (C) may be used alone or in any combination of two or more.

By containing the component (C) in addition to the components (A) and (B), the composition for external use on the skin of the present invention allows water-soluble polysaccharide and nicotinic acid to be absorbed under the influence of heat, visible light, ultraviolet light, etc. Viscosity reduction due to amide is suppressed. Therefore, the skin external composition of the present invention is suitable for use under these influences.

When used under the influence of ultraviolet light, component (C) is not particularly limited, but is preferably an alkylene oxide derivative, a phosphorylcholine-containing polymer, or an alkanediol having 5 to 10 carbon atoms.

The total content of component (C) is not particularly limited and may be appropriately set depending on the type of water-soluble polysaccharide, the type of other ingredients, etc. From the viewpoint of improving the skin composition, preferably 0.001% by mass or more, more preferably 0.005% by mass or more, still more preferably 0.01% by mass or more, even more preferably 0.
0.05% by mass or more, particularly preferably 0.1% by mass or more.
From the viewpoint of improving the stability of the formulation, the total content of component (C) is preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 12% by mass, based on the total amount of the skin external composition. It is not more than 10% by weight, even more preferably not more than 10% by weight, even more preferably not more than 8% by weight.
The total content of component (C) is preferably 0.001 to 2
0% by weight, more preferably 0.005-15% by weight, even more preferably 0.01-12% by weight, even more preferably 0.05-10% by weight, particularly preferably 0.1-8% by weight. .

The total content of component (C) per 1 part by mass of component (B) in the skin external composition of the present invention is not particularly limited, but from the viewpoint of significantly achieving the effects of the present invention, it is preferably 0. .0
001 to 10 parts by weight, more preferably 0.001 to 5 parts by weight, even more preferably 0.01 to 5 parts by weight
3 parts by mass.

In the composition for external use on the skin of the present invention, the content of the alkylene oxide derivative is not particularly limited as long as the effects of the present invention are achieved, and the content of the alkylene oxide derivative is preferably 0.01% based on the total amount of the composition for external use on the skin.
-15% by mass, more preferably 0.1-10% by mass, even more preferably,
It is 0.5 to 8% by mass.

In the composition for external use on skin of the present invention, the content of bisethoxydiglycol cyclohexanedicarboxylate and diethoxyethyl succinate is not particularly limited as long as the effects of the present invention are achieved, and the content is preferably based on the total amount of the composition for external use on skin. is 0.001 to 10% by weight, more preferably 0.005 to 8% by weight, even more preferably 0.01 to 5% by weight, even more preferably 0.05% to 3% by weight. .

In the composition for external use on the skin of the present invention, the content of the 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer relative to the total amount of the composition is not particularly limited as long as the effect of the present invention is achieved. In contrast, preferably 0.0001 to 10% by mass, more preferably 0.001 to 7% by mass, even more preferably 0.005 to 5% by mass, even more preferably 0.01% to 3% by mass. Mass%.

In the composition for external use on skin of the present invention, the content of the alkanediol having 5 to 10 carbon atoms alone is not particularly limited as long as the effects of the present invention are achieved, and the content of the alkanediol having 5 to 10 carbon atoms is preferably 0. .0001 to 10% by weight, more preferably 0.001 to 7% by weight, even more preferably 0.01 to 5% by weight, even more preferably 0.1% to 3% by weight.

[Other ingredients]
In addition to the above-mentioned components (A) to (C), the skin external composition of the present invention has other useful effects, such as an ultraviolet scattering agent, an ultraviolet absorber, and a DNA damage prevention and/or repair effect. whitening ingredient, anti-inflammatory ingredient, antibacterial ingredient, bactericidal ingredient, refreshing agent, organic acid, anti-glycation ingredient, cell activation ingredient, astringent ingredient, antioxidant ingredient, anti-aging ingredient, moisturizing ingredient, polyhydric alcohol ,
Various ingredients such as keratin softening ingredients, vitamins, blood circulation promoting ingredients, sebum adsorption ingredients, peptides or derivatives thereof, amino acids or derivatives thereof, etc. may be blended singly or in combination of two or more.
These components are not particularly limited as long as they can be used in the fields of pharmaceuticals, quasi-drugs, cosmetics, etc., and any components can be appropriately selected and used. Moreover, those that fall under the following plurality of ingredients can be added as ingredients with any efficacy among them.

Examples of the ultraviolet scattering agent include zinc oxide, titanium oxide, iron oxide, cerium oxide,
Inorganic compounds such as zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, and hydrated silicic acid, and these inorganic compounds with inorganic powders such as hydrated silicic acid, aluminum hydroxide, mica, and talc. Examples include those coated or composited with resin powder such as polyamide, polyethylene, polyester, polystyrene, nylon, etc., and those treated with silicone oil, fatty acid aluminum salt, etc. Among these, inorganic compounds such as zinc oxide, titanium oxide, and iron oxide, and those obtained by coating these inorganic compounds with inorganic powders such as aluminum hydroxide, hydrous silicic acid, mica, and talc, and silicone oil are preferable. When blending an ultraviolet scattering component, its content can be appropriately selected in consideration of the feeling of use and effect on the skin, but for example, about 0.001 to 35% by weight based on the total amount of the skin external composition of the present invention. %, preferably about 0.1 to 25% by weight.

Examples of UV absorbers include salicylic acid UV absorbers such as 2-ethylhexyl salicylate, homomenthyl salicylate, or ethylene glycol salicylate; glyceryl diparamethoxycinnamate mono-2-ethylhexanoate; paramethoxycinnamic acid 2 -Cinnamic acid UV absorbers such as ethylhexyl; benzoylmethane UV absorbers such as 4-tert-butyl-4'-methoxydibenzoylmethane; 2-[4-(diethylamino)-2-
benzoic acid ester derivatives such as hexyl benzoate; dimethoxybenzylidene dioxoimidazolidine 2-ethylhexyl propionate; 2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4- (1,1
,3,3-tetramethylbutyl)phenol];2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,
3,5-triazine, diethylhexylbutamide triazone, 2,4,6-tris[4-
Triazine derivatives such as (2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine; benzalmalonate derivatives such as dimethicodiethylbenzalmalonate; UV absorbers; Octocrylene ultraviolet absorbers such as -2-enoic acid 2-ethylhexyl ester; imidazole sulfonic acid derivative ultraviolet absorbers such as 2-phenylbenzimidazole-5-sulfonic acid, phenyldibenzimidazole disodium tetrasulfonate; 2-hydroxy-4 Examples include benzophenone derivative ultraviolet absorbers such as -methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts, dihydroxydimethoxybenzophenone, dihydroxybenzophenone, and tetrahydroxybenzophenone.

In the present invention, examples of such UV absorbers include, but are not limited to, 2-ethylhexyl paramethoxycinnamate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-[4-(diethylamino)- 2-Hydroxybenzoyl]benzoic acid hexyl ester, dimethoxybenzylidene dioxoimidazolidine propionate 2-ethylhexyl, 2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1)
,3,3-tetramethylbutyl)phenol], 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,
3,5-triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, dimethicodiethylbenzalmalonate, 2-cyano-3,3- One or more selected from the group consisting of diphenylprop-2-enoic acid 2-ethylhexyl ester and 2-phenylbenzimidazole-5-sulfonic acid are preferred.

The ultraviolet absorber may be a commercially available product or may be synthesized.

Commercially available products include, but are not limited to, Parsol EHS (manufactured by DSM Nutrition Japan) and ESCALOL 587 (manufactured by Ashland Japan).
, EusolexOS (manufactured by Merk), Parsol HMS (manufactured by DSM Nutrition Japan), Uvinul MC80 (manufactured by BASF), Parsol MCX
(manufactured by DSM Nutrition Japan), Parsol 1789 (manufactured by DSM Nutrition Japan), Uvinal A Plus Granular, Soft Shade D
H, Tinosorb M (manufactured by BASF), Milestab 360, Mixxim
BB/100, Tinosorb S (manufactured by BASF), Uvasorb HEB, Uvinal T150 (manufactured by BASF), Heliosun OTZ (O'Laughli
n Industries), Parsol SLX (DSM Nutrition Japan), Parsol 340 (DSM Nutrition Japan), Escarole 597 (Ashland Japan), Parsol HS (DSM Nutrition Japan), Eusolex 232 (Merck ), NeoHeliopan
AP (manufactured by Herman & Reimer), Yubinar M40, Escarol 567 (manufactured by Ashland Japan), Yubinar MS40 (manufactured by BASF), SEESORB107 (manufactured by Cipro Kasei), SEESORB100 (manufactured by Cipro Kasei), SEESORB106 (manufactured by Cipro Kasei) (manufactured by a company)

In the skin external composition of the present invention, the total content of ultraviolet absorbers is preferably 1% by mass or more, more preferably 3% by mass or more, still more preferably 6% by mass, based on the total amount of the composition. The content is even more preferably 7% by mass or more. In addition, the total content of ultraviolet absorbers is
The amount is preferably 20% by mass or less, more preferably 15% by mass or less, even more preferably 10% by mass or less, based on the total amount of the composition. Further, the total content of the ultraviolet absorber is preferably 1 to 20% by mass, more preferably 3 to 15% by mass, even more preferably 5 to 10% by mass, and even more preferably is 7 to 10% by mass.

In the skin external composition of the present invention, the ratio of the total content of ultraviolet absorbers to component (B) is not particularly limited, but preferably 0
．． The amount is 1 to 6 parts by weight, more preferably 0.5 to 4 parts by weight, and even more preferably 1 to 2 parts by weight.

Moreover, these ultraviolet scattering agents and ultraviolet absorbers may be composited, supported, or encapsulated by another component, and the combination thereof is not particularly limited.

Examples of components having the effect of preventing and/or repairing DNA damage include components derived from animals (e.g., Artemia); components derived from plants (e.g., cat's claw);
Examples include nucleic acid components such as A, DNA salts, RNA, and RNA salts. Prevention of DNA damage and/or
Alternatively, the content of the component having a restorative action can be appropriately selected in consideration of the feeling of use and effect on the skin, but for example, about 0.001 to 3% by mass based on the total amount of the skin external composition of the present invention. , preferably about 0.01 to 1% by weight. When animal components or plant components are used, the content is preferably about 0.0 based on the total amount of the skin external composition of the present invention in terms of extracts such as extracts.
0001 to 0.1% by weight, more preferably about 0.0001 to 0.01% by weight.

Examples of whitening ingredients include placenta; arbutin; kojic acid; ellagic acid; phytic acid; tranexamic acid; rusinol; chamomilla ET; hydroquinone, 4-methoxysalicylic acid potassium salt; linoleic acid and its derivatives; ascorbic acid and its salts, and ascorbin. Vitamin C such as acid derivatives (sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, ascorbyl tetra-2-hexyldecanoate, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, ascorbic acid glucoside, Disodium stearyl ascorbyl phosphate, L-ascorbyl dipalmitate, trisodium ascorbyl palmitate phosphate, glyceryl ascorbic acid, bisglyceryl ascorbic acid, disodium ascorbic acid sulfate, hexyl 3-glyceryl ascorbic acid, 3-glyceryl ascorbic acid , myristyl 3-glyceryl ascorbic acid,
(3-laurylglyceryl ascorbic acid, potassium (ascorbyl/tocopheryl) phosphate, ascorbyl tocopheryl maleate, etc.); vitamins such as vitamin A or its derivatives, pantothenic acid or its derivatives, and the like. Furthermore, botanical ingredients having a whitening effect may be used as the whitening ingredient, and such botanical ingredients include iris, almond, aloe, acerola, oolong tea, iris, scutellariae, orensis, hypericum, perforatum, dead networt, seaweed, cuckoo, Gardenia, Kujin, Chlorella, Rice, Rice moth, Oryzanol, Rice bran, Saishin, Japanese pepper, Perilla, Peony, Senkyu, Souhakuhi, Soybean, Natto, Tea, Angelica, Calendula, Hamamelis, Safflower, Botanpi,
Japanese acacia, kiwi, black bean, gentian, Japanese radish, sage, radish, azalea, parsley, holly, hop, thyme, clove, chimpi, daylily, chamomile, prune, meadowsweet, purple bean, sagebrush, grapefruit, thorn pear,
Ingredients derived from lemon, kiwi, pine, neem, artichoke, horsetail, Japanese primrose, night primrose, bilberry, Japanese primrose, salicaria, white willow, saxifrage, centella asiatica, rosemary, lavender, cornelian and the like can be mentioned. When these plant components are used in the skin external composition of the present invention, the form of the plant components is not particularly limited, but they can usually be used in the form of plant extracts, essential oils, and the like. In addition, what is in parentheses in the above-mentioned plant ingredients is the scientific name, another name, or crude drug name of the plant.

In the present invention, although not particularly limited, such whitening ingredients include placenta;
Arbutin; Kojic acid; Ellagic acid; Phytic acid; Tranexamic acid; Rucinol; Chamomilla ET; Hydroquinone; 4-methoxysalicylic acid potassium salt; Linoleic acid and its derivatives; Ascorbic acid, sodium ascorbate, sodium ascorbic acid phosphate, ascorbic acid Magnesium phosphate ester, ascorbyl tetra-2-hexyldecanoate, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, ascorbic acid glucoside; vitamin A oil; iris, almond, aloe, acerola, iris, scutellariae, oren, Hypericum perforatum, Hypericum perforatum, seaweed, cuckoo, chlorella, rice, rice moth, oryzanol, rice bran, perilla, peony, soybean, soybean, tea, calendula, hamamelis, botanpi, yokuinin, kiwi, sage, parsley, holly, hops, thyme, clove , Chimpi, daylily, chamomile, prunes, meadowsweet, purple beetles, cornweed, grapefruit, thorn pear, lemon, kiwi, pine, neem, artichoke, horsetail, plantain, evening primrose, bilberry, sycamore, salicaria, white willow, saxifrage, centella asiatica, rosemary One or more kinds selected from the group consisting of extracts extracted from , lavender, and cornelian are preferred;
Placenta; Arbutin; Kojic acid; Phytic acid; Tranexamic acid; Hydroquinone;
Ascorbic acid, sodium ascorbate, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, ascorbyl tetra-2-hexyldecanoate, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, ascorbic acid glucoside; vitamin A Oil: Iris root extract, almond oil, aloe vera extract, acerola extract, age extract, scutellariae extract, hypericum extract, deadlock root extract,
Seaweed extract, cacao extract, chamomile extract, peony extract, sour cherry extract,
Soybean extract, tea extract, white tea extract, calendula, hamamelis, chinensis, adlay extract, hop extract, prune extract, licorice extract, oil-soluble licorice extract, meadowsweet extract, purple radish extract, alpinia radish seed extract,
Grapefruit extract, thorn extract, lemon extract, kiwi extract, pine extract, neem leaf extract, artichoke extract, horsetail extract, Japanese trumpet extract, night primrose extract, evening primrose oil, bilberry leaf extract, Japanese primrose extract, salicaria extract, white willow extract, centella asiatica extract, and One or more types selected from the group consisting of cornelian fruit extracts are more preferable.

When the above-described skin whitening ingredient is added to the skin external composition of the present invention, the content thereof can be appropriately selected in consideration of the feeling and effect on the skin. , about 0.0003 to 10% by weight, preferably about 0.01 to 5% by weight. When using plant extracts, the content is calculated in terms of extracts such as extracts, based on the total amount of the composition for external use on the skin.
For example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, more preferably 0.001 to 10% by weight.

Examples of anti-inflammatory ingredients include allantoin, calamine, tranexamic acid, glycyrrhizic acid or its derivatives, or salts thereof (e.g., dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, etc.), glycyrrhetinic acid, its derivatives, or salts thereof (e.g., glycyrrhetinic acid, stearyl glycyrrhetinate, etc.), zinc oxide, aminocaproic acid, azulene and its derivatives (e.g., guaiazulene, azulene, etc.), tocopherol acetate, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin, salicylic acid or its derivatives, steroids or derivatives thereof or salts thereof (e.g., hydrocortisone, prednisolone), ufenamate, bufexamac, ibuprofen piconol, glycol salicylate, components derived from plants (e.g., comfrey, orensis, dokudami), and the like. The anti-inflammatory component is preferably selected from the group consisting of allantoin, tranexamic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, aminocaproic acid, azulene and its derivatives, azulene and its derivatives, or Dokudami extract. More preferably, one or two selected from the group consisting of allantoin, tranexamic acid, dipotassium glycyrrhizinate, glycyrrhetinic acid, and aminocaproic acid.
More than a species. When blending an anti-inflammatory component, the content can be appropriately selected in consideration of the feeling and effect on the skin, but for example, about 0.000% of the total amount of the skin external composition of the present invention.
3 to 10% by weight, preferably about 0.01 to 5% by weight.

Examples of antibacterial or bactericidal ingredients include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, and triclosan. , Photosensor No. 101, Photosensor No. 201, Paraben,
Phenoxyethanol, alkyldiaminoglycine hydrochloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, pyroctoolamine, zinc pyrithione, miconazole or its salt, chlorobutanol, glyceryl caprylate, ethylhexylglycerin,
Butylcarbamate propynyl iodide, caprylic hydroxamic acid, phenethyl alcohol, methylisothiazolinone, sorbic acid, β-glycyrrhetinic acid, azelaic acid, vegetable (
Examples include ingredients derived from clara, rosemary, mulberry, eucalyptus, etc.).
Among them, salicylic acid, benzalkonium chloride, ethanol, cetylpyridinium chloride,
Cetyltrimethylammonium chloride, gluconic acid, isopropylmethylphenol, parabens, phenoxyethanol, cetylpyridinium chloride, zinc pyrithione, chlorobutanol, ethylhexylglycerin, propynyl butylcarbamate iodide, caprylic hydroxamic acid, sorbic acid, β-glycyrrhetinic acid, rosemary extract , eucalyptus extract is preferred. When blending an antibacterial component or a bactericidal component, the content can be appropriately selected in consideration of the feeling and effect on the skin, but for example, about 0.0003% of the total amount of the skin external composition of the present invention. ~10% by weight, preferably about 0
．． 001 to 5% by mass.

Examples of cooling agents include menthol and its derivatives, terpenes such as camphor, borneol, geraniol, cineol, anethole, limonene, and eugenol (these may be in the d-, l-, or dl-form); eucalyptus oil , bergamot oil, peppermint oil, coolmint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose oil, turpentine oil, and other essential oils. Among these, combinations with l-menthol, menthyl glyceryl ether, menthyl lactate, menthyl 3-hydroxybutyrate, menthoxypropanediol, camphor, eucalyptus oil, peppermint oil, and peppermint oil are preferred. When blending a refreshing agent, its content can be appropriately selected in consideration of the feeling and effect on the skin, but for example, 0.001 to 5% by weight based on the total amount of the skin external composition of the present invention. % or more, preferably 0.005 to 3% by mass or more, more preferably 0.01 to 1% by mass or more.

Examples of the organic acids include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, malonic acid, maleic acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid, lactic acid,
Examples include pantothenic acid, glycyrrhetinic acid, alginic acid, ascorbic acid, benzoic acid, adipic acid, glutamic acid, azelaic acid, and salts thereof. Examples of salts include mineral acid salts such as sulfuric acid, hydrochloric acid or phosphoric acid, organic acid salts such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium salts, alkaline earth metal salts, ammonium salts, Examples include basic amino acid salts and amine salts such as triethanolamine. Among them, a combination with one or more selected from gluconic acid, citric acid, glutamic acid, succinic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, lactic acid, and glycyrrhetinic acid is more preferable.

Examples of anti-glycation components include Buddleja axillaris leaf extract, plum fruit extract, edelweiss extract, ginkgo biloba extract, cherry leaf extract, pomegranate extract, plantain extract, hawthorn extract, peony extract, dokudami extract, bilberry leaf extract, Plant extracts such as green tea extract, black tea extract, horse chestnut extract, Roman chamomile extract, mugwort extract, evening primrose oil, amla fruit, fruit juice or their extracts, L-arginine, L-lysine, hydrolyzed casein, hydrolysable tannin , carnosine, etc.
When blending an anti-glycation component, its content can be appropriately selected in consideration of the feeling of use and effect on the skin, but it is, for example, about 0.0003 to 10 mass%
, preferably about 0.001 to 5% by weight.

Examples of cell activation components include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acid, and pyrroloquinoline quinones; gluconic acid, phytic acid, α-Hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponins, allantoin, placenta, proteoglycans, photosensitizer No. 301, plants (e.g., soybean, bilberry, lemongrass, aloe vera, chlorella, chinensis, chinensis, chamomile, dokudami) ,hop,
royal jelly, royal jelly extract; whey, yogurt extract, whey-derived extracts such as hydrolyzed milk protein, yeast extract, etc. When a cell activating component is blended, its content can be appropriately selected in consideration of the feeling of use and effect on the skin, but for example, from about 0.0003 to 10% by weight, preferably about 0.001-5% by weight.

Examples of astringent components include metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc paraphenolsulfonate, zinc sulfate, potassium aluminum sulfate, and basic zinc aluminum lactate; tannic acid, citric acid, and lactic acid. , organic acids such as succinic acid, plants (e.g. seaweed, thyme, black tea, oolong tea, green tea,
Ingredients derived from hypericum perforatum, hamamelis, loquat, botanpi, saxifrage, rooibos, astragalus, artichoke, chamomile, eucalyptus, lemon, rosemary, fireweed, etc.) are included. When blending an astringent component, its content can be appropriately selected in consideration of the feeling of use and effect on the skin, but for example, the content may be about 0.
0003 to 20% by weight, preferably about 0.01 to 10% by weight.

Examples of antioxidant components include butylhydroxyanisole, dibutylhydroxytoluene, sodium bisulfite, sodium pyrosulfite, erythorbic acid and its salts, ascorbic acid and its salts, flavonoids, glutathione, glutathione peroxidase,
Glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiotaurine, hypotaurine, plants (e.g. Hypericum perforatum, cuckoo, bilberry, scutellariae, passionflower, grapefruit, peony, meadowsweet, perilla, honeysuckle, sage, yarrow, mallow , Meadowsweet, Souhakuhi, Clove, Chinpi, Himefuro, Loquat, Safflower, Botanpi,
Examples include ingredients derived from hops, eucalyptus, saxifrage, rooibos, lemongrass, soybean, mugwort, evening primrose, rosemary, lavender, etc. When blending an antioxidant component, its content can be appropriately selected in consideration of the feeling of use and effect on the skin, but it is, for example, about 0.00001 to 10% by mass based on the total amount of the skin external composition of the present invention. , preferably about 0
．． 0001 to 5% by weight, more preferably 0.001 to 5% by weight.

Anti-aging ingredients include, for example, hydrolyzed soy protein, retinoids (retinol, retinoic acid, retinal, etc.), pangamic acid, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone. , peptides (caprooyl tetrapeptide-3, oligopeptide-24, etc.), plants (artichoke, thorns, seaweed, bilberry, birch, plantain, Japanese trumpet, Scutellaria annua, Hypericum perforatum, comfrey, neem, wild rose, Japanese thorn, Japanese trumpet , Bodaiju,
Buttonpi) etc. Among them, hydrolyzed soy protein, retinol, retinol acetate, retinol palmitate, caprooyl tetrapeptide-3, oligopeptide-24.
, artichoke leaf extract, seaweed extract, bilberry leaf extract, comfrey leaf extract,
Neem leaf extract and neem leaf extract are preferred. When blending anti-aging ingredients, the content can be selected as appropriate in consideration of the feeling and effect on the skin, but for example, about 0.0003 to 10% of the total amount of the skin external composition of the present invention. % by weight, preferably about 0.01-5% by weight
It is.

Examples of moisturizing ingredients include amino acids and their derivatives such as alanine, serine, aspartic acid, glycine, proline, hydroxyproline, glucosamine, theanine, and arginine; polyhydric alcohols such as glycerin, dipropylene glycol, and 1,3-butanediol. ; Sugar alcohols such as sorbitol, xylitol, erythritol, maltose-sucrose condensates (glucooligosaccharides), and hydrolyzed xylan (xylooligosaccharides); Glycosyltrehalose, trehalose; Ceramide, glucosylceramide, cholesterol, phytosterols, cholesterol derivatives, phytosterol derivatives, Phospholipids such as lecithin and hydrogenated lecithin; NMF-derived components such as lactic acid, sodium lactate, sodium pyrrolidone carboxylate, and urea; hyaluronic acid (including hydrolyzed hyaluronic acid, low-molecular-weight hyaluronic acid, etc.); salts of hyaluronic acid ( For example, sodium hyaluronate, zinc hyaluronate, low molecular weight zinc hyaluronate, etc.); hyaluronic acid derivatives (acetylated hyaluronic acid or its salts (e.g., acetylated sodium hyaluronate, acetylated zinc hyaluronate, etc.), cross-linked hyaluronic acid Derivatives (hyaluronic acid crosspolymer Na, etc.), carboxymethyl hyaluronic acid N
a, unsaturated hyaluronic acid or its salt, hydrolyzed alkyl (C12-13) hyaluronate glyceryl, cationized hyaluronic acid derivative (hydroxypropyltrimonium hyaluronate, etc.), dimethylsilanol hyaluronate, etc.); chondroitin sulfate or its salt ( sodium chondroitin sulfate, potassium chondroitin sulfate, sodium dermatan sulfate, potassium dermatan sulfate, etc.); collagen, elastin, keratin, chitin, chitosan, etc. and their hydrolysates; hydroxyethyl urea; , lemongrass, chamomile, hamamelis, tea, perilla, grapefruit,
Ingredients derived from Jiaogulan, etc.). Among them, glycine, arginine,
Glycerin, dipropylene glycol, 1,3-butanediol, glycosyltrehalose, ceramide, glucosylceramide, cholesterol, cholesterol derivative, phytosterol derivative, hydrogenated lecithin, lactic acid, sodium lactate, sodium pyrrolidone carboxylate, urea, hydrolyzed hyaluronic acid, Low molecular weight hyaluronic acid, sodium hyaluronate,
Zinc hyaluronate, low molecular weight zinc hyaluronate, acetylated hyaluronic acid, hyaluronic acid crosspolymer Na, hydroxypropyltrimonium hyaluronate, dimethylsilanol hyaluronate, collagen, elastin, keratin, hydroxyethyl urea, seaweed extract, chamomile extract, Hamamelis Preferably, one or two or more selected from the group consisting of hyaluronic acid or a salt thereof, a hyaluronic acid derivative, and chondroitin sulfate or a salt thereof is preferable, from the viewpoint of improving the feeling of use. It is more preferable to use more than one species. When blending a moisturizing ingredient, the content can be appropriately selected in consideration of the feeling and effect on the skin, but for example, about 0.001% of the total amount of the skin external composition of the present invention.
-20% by weight, preferably about 0.01-10% by weight.

Examples of polyhydric alcohols include diols having 2 to 4 or 11 or more carbon atoms, polyhydric alcohols having 3 or more hydroxy groups, and examples thereof include glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, ethylene glycol,
Diethylene glycol, isoprene glycol, 1,3-butylene glycol, 1,3-
Examples include propanediol. Among these, a combination with one or more selected from glycerin, diglycerin, propylene glycol, dipropylene glycol, and 1,3-butylene glycol is preferred. When blending a polyhydric alcohol, its content can be appropriately selected in consideration of the feeling of use on the skin and the moisturizing effect, but it is, for example, about 0.1 to 20% by weight, preferably about 0.5-15% by weight.

Examples of keratin softening ingredients include lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, citric acid, fruit acid, tartaric acid, succinic acid, oxalic acid,
Examples include gluconic acid, ferulic acid, and sulfur. Among these, one or more selected from the group consisting of lactic acid, sodium lactate, glycolic acid, salicylic acid, phytic acid, citric acid, and gluconic acid are preferred. When a keratin softening ingredient is blended, its content can be appropriately selected in consideration of the feeling of use and effect on the skin, but for example, 0.0001 to 50% by weight based on the total amount of the skin external composition of the present invention. %, preferably about 0.001 to 50% by weight, more preferably about 0.01 to 25% by weight.

Examples of vitamins include retinol, retinol derivatives such as retinol acetate, retinol palmitate, retinol propionate, and retinol linoleate, retinal,
Retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoate, d
-Vitamin A such as δ-tocopheryl retinoate, α-tocopheryl retinoate, β-tocopheryl retinoate; β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, Provitamins A such as echinenone; δ-tocopherol, dl-α-tocopherol dl-α-tocopherol succinate,
dl-α-tocopherol calcium succinate, tocopherol nicotinate, dl-acetate
Vitamin E such as α-tocopherol, tocopherol linoleate, tocopherol (linoleic acid/oleic acid), potassium (ascorbyl/tocopheryl) phosphate; γ-oryzanol, thiamine, and their salts (e.g., dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine diphosphate), etc., riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, sodium riboflavin 5'-phosphate, riboflavin tetranicotinate, and Vitamin B2 such as their salts; nicotinic acids other than the above component (B) such as benzyl nicotinate, methyl nicotinate, and nicotinic acid; ascorbyl stearate, disodium isostearyl ascorbyl phosphate, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate),
Ascorbyl palmitate trisodium phosphate, ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, ascorbic acid glucoside, 2-O-ethyl ascorbic acid, 3-O-ethyl Ascorbic acid, glyceryl ascorbic acid, bisglyceryl ascorbic acid, hexyl 3-glyceryl ascorbic acid, 3-glyceryl ascorbic acid, myristyl 3-glyceryl ascorbic acid, 3-laurylglyceryl ascorbic acid,
Vitamin C such as (ascorbyl/tocopheryl) phosphate, (ascorbyl/tocopheryl) potassium phosphate, ascorbyl tocopheryl maleate; methylhesperidin,
Vitamin D such as ergocalciferol and cholecalciferol; Vitamin K such as phylloquinone and farnoquinone; Vitamins such as thiamine and their salts (e.g. dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine diphosphate), etc. Class B1; Vitamin B6 such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, and pyridoxamine hydrochloride; Vitamin B12 such as cyanocobalamin, hydroxocobalamin, and deoxyadenosylcobalamin; folic acid such as folic acid and pteroylglutamic acid. Class; pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol),
Pantothenic acids such as D-pantetheine, D-pantethine, coenzyme A, pantothenyl ethyl ether, and calcium pantetheine sulfonate; biotins such as biotin and biocytin;
Other vitamin-like agents include carnitine, ferulic acid, α-lipoic acid, orotic acid, γ-oryzanol, pyrroloquinoline quinone, hesperidin and glucosylhesperidin, ubiquinone, and salts thereof. Among these, one or more selected from the group consisting of vitamin Bs, vitamins C, vitamins E, vitamins A, and vitamin-like acting factors are preferred, including pyridoxine hydrochloride, pantothenyl alcohol (panthenol), riboflavin, Cyanocobalamin, ascorbic acid, ascorbyl glucoside, 3-O-ethyl ascorbic acid, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, dl-α-tocopherol acetate, ascorbyl palmitate, ascorbyl tetra-2-hexyldecanoate , retinol, retinol palmitate, retinol propionate, retinol acetate, pyrroloquinoline quinone or its salt, ubiquinone, and γ-oryzanol. When blending vitamins, the content can be appropriately selected in consideration of the feeling of use and effect on the skin, but for example, about 0.001 to 30% by weight based on the total amount of the skin external composition of the present invention. %, preferably about 0.01 to 25% by weight, more preferably about 0.01 to 20% by weight.

Examples of blood circulation-promoting ingredients include plants such as Panax ginseng, Ashitaba, arnica, ginkgo, fennel, Japanese radish, Dutch oak, chamomile, Roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake, ginger, hawthorn, Japanese juniper, nebula, japonica, thyme, clove, chimpi, Japanese horse chestnut, thorn, spruce, carrot, garlic, butcher bloom, grape, button, horse chestnut,
Ingredients derived from melissa, yuzu, walnut, rosemary, rosehip, peach, apricot, walnut, corn); dl-α-tocopherol acetate, tocopherol nicotinate, glucosylhesperidin, hesperidin, caffeine, capsicum tincture, γ-oryzanol , capsaicin, nicotinic acid benzyl ester, and the like. When blending a blood circulation-promoting component, the content can be appropriately selected in consideration of the feeling of use and effect on the skin, but it is, for example, about 0.00001 to 10 % by weight, preferably from 0.0001 to 5% by weight, more preferably from about 0.001 to 5% by weight. When using plant-derived components, the content is, for example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass, based on the total amount of the skin external composition, in terms of extracts such as extracts. %, more preferably 0.001 to 10% by mass.

Examples of sebum-adsorbing ingredients include talc, mica, hydroxyapatite, zinc oxide,
Examples include aluminum silicate, and preferably mica, hydroxyapatite, and
One or more types selected from the group consisting of zinc oxide, and mica is particularly preferred. When blending a sebum-adsorbing component, its content can be appropriately selected in consideration of the feeling of use and effect on the skin. % by weight, preferably about 0.1-25% by weight.

Examples of peptides or derivatives thereof include keratinolytic peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, succinylated atelocollagen,
Gelatin, elastin, elastin-degraded peptide, collagen-degraded peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degraded peptide, conchiolin-degraded peptide, hydrolyzed conchiolin, silk proteolytic peptide,
Hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptide, hydrolyzed wheat protein, caseinolytic peptide, acylated peptide (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl) tetrapeptide, etc.). Among them, keratin-degrading peptides, hydrolyzed keratin, fish-derived collagen elastin, elastin-degrading peptides, collagen-degrading peptides, hydrolyzed collagen, succinylated atelocollagen, elastin-degrading peptides,
More preferably, one or more selected from hydrolyzed silk, soybean proteolytic peptide, and hydrolyzed soybean protein. When blending a peptide or a derivative thereof, its content can be appropriately selected in consideration of the feeling and effect on the skin, but it is, for example, about 0.0001 to 0.0001 to the total amount of the skin external composition of the present invention. 35% by weight, preferably about 0.001-10% by weight.

Examples of amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine. , methionine, leucine, isoleucine, valine, histidine, threonine, tyrosine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, epsilon aminocaproic acid, tryptophan, ornithine, di(phytosteryl lauroylglutamate) /octyldodecyl), di(octyldodecyl/phytosteryl/behenyl) lauroylglutamate, and the like. In addition, these amino acids or derivatives thereof may be solvates such as hydrates,
Furthermore, it may be any of the d-form, l-form, and dl-form. Among these, one or more selected from l-amino acids or derivatives thereof are preferred.

In addition to the components (A) to (C), the skin external composition of the present invention may also be used in the fields of pharmaceuticals, quasi-drugs, cosmetics, etc., depending on the use or dosage form. Commonly used components may be appropriately blended. Components that can be blended are not particularly limited, but include, for example, bases or carriers, surfactants, thickeners, antioxidants, preservatives, preservatives, pH adjusters, chelating agents, stabilizers, and irritation reducing agents. , colorants, dispersants, fragrances, and other additives may be added. In addition, these components can be blended singly or in any combination of two or more. Moreover, these contents can be appropriately determined from conventionally known ranges within a range that does not impair the effects of the present invention. Furthermore, the following components can be added as components with any function.

As a base or carrier, an aqueous base such as water; liquid paraffin, liquid isoparaffin, squalane, vaseline, paraffin, microcrystalline wax, polybutene, polyethylene powder, gelled hydrocarbon (Plastibase etc.), ozokerite, α-olefin oligomer , light liquid paraffin, light isoliquid paraffin; methylpolysiloxane, crosslinked methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicone, alkyl-modified silicone, crosslinked alkyl-modified silicone, amino-modified silicone, polyether Modified silicone, polyglycerin-modified silicone, cross-linked polyether-modified silicone, cross-linked alkyl polyether-modified silicone, silicone/alkyl chain co-modified polyether-modified silicone, silicone/alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone , polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, silicone oil such as silicone resin; higher alcohols such as cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, isostearyl alcohol, phytosterol, cholesterol; Higher fatty acids such as isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, and behenic acid; cellulose derivatives such as carboxymethylcellulose, hydroxyethylcellulose, ethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose; polyvinylpyrrolidone; polyethylene glycol; dioxane; butylene glycol adipate polyester; isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythrite tetra-2-ethylhexanoate, diisopropyl adipate, oleic acid Decyl, isodecyl oleate, hexyldecyl dimethyloctanoate, diisopropyl sebacate, di-2 sebacate
- Ethylhexyl, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, diisopropyl adipate, isotridecyl isononanoate, cetyl lactate, isostearyl isostearate, cholesteryl 12-hydroxystearate, cholesteryl stearate, cholesteryl oleate, macadamia nuts Phytosteryl fatty acid, phytosteryl oleate, dextrin palmitate, inulin stearate, hydrogenated jojoba oil, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, neopentyl glycol dicaprate, tri-2-ethylhexyl trimellitate, trimellitic acid Tridecyl, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane triisostearate, tri(caprylic acid/ capric acid) glyceryl, tri(caprylic acid/capric acid/
myristic acid/stearic acid) glyceryl, oleyl oleate, di(phytosteryl/octyldodecyl) lauroylglutamate, di(octyldodecyl/phytosteryl/behenyl) lauroylglutamate, triethyl citrate, dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/ stearyl/behenyl), dimer dilinoleyl dilinoleate, dipentaerythrityl tripolyhydroxystearate, tri(
Esters such as behenic acid/isostearic acid/eicosandioic acid) glyceryl; Waxes such as jojoba oil, miur wax, candelilla wax, rice bran wax, cotton wax, carnauba wax, lanolin; avocado oil, linseed oil, camellia oil, macadamia nut oil , corn oil, olive oil, safflower oil, kyonin oil, cinnamon oil, jojoba oil, grape seed oil, sunflower oil, almond oil, shea butter, sasanquat oil, rapeseed oil, sesame oil, cacao butter, coconut oil, hydrogenated coconut oil, Oils and fats such as palm oil, palm kernel oil, Japanese oak kernel oil, Japanese oak, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil; dextrin, maltodextrin; carboxyvinyl Polymers, vinyl polymers such as alkyl-modified carboxyvinyl polymers; lower alcohols such as ethanol and isopropanol; sorbitol,
Examples include sugar alcohols such as xylitol, erythritol, and mannitol; water, and the like.
These components may be used alone or in combination of two or more. Further, the amounts used are appropriately selected from the range known to those skilled in the art. Among these, from the viewpoint of improving the feeling of use, it is preferable that the skin external composition of the present invention contains a cellulose derivative as a base or carrier. When the skin external composition of the present invention contains water, the water content varies depending on the form of the composition and is not particularly limited. For the total amount of the skin external composition of the present invention, for example,
The water content is preferably 5-99%, more preferably 8-95%, even more preferably 10-90%.

Examples of the surfactant include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monostearate, diglycerol tetra-2-ethylhexylate sorbitan, sorbitan monooleate, sorbitan monoisostearate, and sorbitan monolaurate; Polyoxyethylene monolaurate (20) sorbitan, polyoxyethylene monolaurate (80) sorbitan, polyoxyethylene monostearate (2
0) Polyoxyethylene sorbitan fatty acid esters such as sorbitan, polyoxyethylene monooleate (20) sorbitan, polyoxyethylene isostearate (20) sorbitan; glycerin monooleate, glycerin monostearate, glycerin monomyristate, etc. Glycerin fatty acid esters; glycerin alkyl ethers such as monoisostearyl glyceryl ether and monomyristyl glyceryl ether; polyglycerols such as diglyceryl monostearate, decaglyceryl decastearate, decaglyceryl decaisostearate, and diglyceryl diisostearate Fatty acid ester; propylene glycol fatty acid esters such as propylene glycol monostearate; hardened polyoxyethylene hydrogenated castor oil 40, polyoxyethylene hydrogenated castor oil 50, polyoxyethylene hydrogenated castor oil 60, polyoxyethylene hydrogenated castor oil 80, etc. Castor oil derivatives; polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monococonut oil fatty acid glyceryl; polyoxyethylene alkyl ethers such as polyoxyethylene cetyl ether;
Polyoxyethylene sterol/hydrogenated sterol such as polyoxyethylene (20) phytosterol, polyoxyethylene (30) phytosterol, polyoxyethylene (25) phytostanol, polyoxyethylene (30) cholestanol; sucrose fatty acid ester; alkyl Phosphoric acid ester salt, N-acylamino acid salt, acylated taurate; Amines such as stearylamine and oleylamine; Polyoxyethylene/methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9
Examples include silicone surfactants such as polydimethylsiloxyethyl dimethicone, and naturally derived surfactants such as lecithin, hydrogenated lecithin, saponin, surfactin sodium, cholesterol, and bile acids.

Examples of the thickener include vinyl thickeners such as polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl methyl ether, and carboxyvinyl polymer, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, Cellulose thickeners such as carboxyethyl cellulose, dextran, alkyl acrylate methacrylate copolymer, sodium polyacrylate, bentonite, dextrin fatty acid ester, dimethyl distearyl ammonium hectorite, polyethylene glycol, macrogol, (hydroxyethyl acrylate) /acryloyldimethyltaurate Na) copolymer, (acryloyldimethyltaurate ammonium/vinylpyrrolidone)
Examples include copolymers and the like.
Among them, acrylic acid alkyl methacrylate copolymer, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxyvinyl polymer, dimethyldistearylammonium hectorite, (hydroxyethyl acrylate/acryloyldimethyltaurine Na) copolymer, (acryloyldimethyltaurine) Ammonium/vinylpyrrolidone) copolymers are preferred.

Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, ascorbic acid derivatives, tocopherol, tocopherol derivatives, erythorbic acid, sodium erythorbate, L-cysteine hydrochloride, coenzyme Q10, etc. ubiquinones, lignans such as sesamin, curcumin, capsaicin, gingerol, resveratrol, anthocyanins, cyanidin,
Examples include bilberry extract and analogs or derivatives thereof.

Examples of preservatives or preservatives include benzoic acid, sodium benzoate, dehydroacetic acid,
Sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, benzyl paraoxybenzoate, methyl paraoxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, sorbic acid and Salts thereof, chlorhexidine gluconate, methylisothiazolinone, propynyl butylcarbamate iodide, caprylic hydroxamic acid, phenethyl alcohol, ethylhexylglycerin, glyceryl caprate, isopropylmethylphenol, and the like. When blending an antiseptic/preservative, the content can be appropriately selected in consideration of the feeling and effect on the skin, but for example, about 0.001% of the total amount of the skin external composition of the present invention. % to 5% by weight, preferably from about 0.01 to 5% by weight
It is 1% by mass.

Examples of pH adjusting agents include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), and inorganic bases (potassium hydroxide, hydroxide, etc.). (sodium, etc.), potassium carbonate, sodium hydrogen carbonate, carbon dioxide, organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.), and the like.

Examples of chelating agents include ethylenediaminetetraacetic acid (edetate), ethylenediaminetetraacetate (sodium salt (sodium edetate: Japanese Pharmacopoeia, EDTA-2Na, etc.)
, potassium salt, etc.), phytic acid, gluconic acid, polyphosphoric acid, metaphosphoric acid, etc. Among these, sodium edetate is preferred.

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole, and the like.

Examples of irritation reducing agents include licorice extract, polyvinylpyrrolidone, and the like.

[viscosity]
The viscosity (25° C.) of the skin external composition of the present invention is not particularly limited as long as it is within the range of 1 to 500,000 mPa·s, but from the viewpoint of significantly achieving the effects of the present invention, it is preferably 2 to 500,000 mPa·s.
500,000 mPa·s, more preferably 5 to 450,000 mPa·s, still more preferably 100 to 400,000 mPa·s, even more preferably 200 to 300,000 mP
a.s, particularly preferably 500 to 300,000 mPa.s. A composition for external use on the skin having such a viscosity can be obtained mainly by appropriately selecting the type and content of the thickener, which is an added component.

In the present invention, the viscosity is measured using a single cylindrical rotational viscometer (Brookfield type viscometer) in accordance with the viscosity measurement method described in the General Test Methods of the 17th Edition of the Japanese Pharmacopoeia. In this application, TV-10M (Toki Sangyo) is used, and the conditions such as rotor and rotation speed are selected in accordance with the instruction manual of this machine, and the viscosity at 25°C is measured. A description of a single cylinder rotational viscometer is provided below. A single cylinder rotational viscometer is a viscometer that measures the torque when a cylinder in a liquid is rotated at a constant angular velocity. By experimentally determining the device constant KB in advance using a standard solution for calibrating the viscometer, the viscosity η of the liquid is calculated by the following equation.
η=KB × T/ω
η: Liquid viscosity (mPa・s)
KB: Device constant (rad/cm3)
ω: Angular velocity (rad/s)
T: Torque acting on the cylindrical surface (10-7N・m)

[pH]
The composition for external use on the skin of the present invention should normally have a liquid pH of 2.0 to 9.0, but from the viewpoint of low irritation to the skin and mucous membranes and good skin feel, it is preferably pH 3.
．． The pH is 0 to 8.5, more preferably 4.0 to 8.0.

[Method for producing skin external composition]
The method for producing the skin external composition of the present invention is not particularly limited, and in addition to the above components (A) to (C),
It can be produced by appropriately selecting and blending the other components mentioned above, and performing emulsification if necessary in a conventional manner.

[Properties/Formulation]
The properties of the skin external composition of the present invention are not particularly limited, and may be liquid, fluid, or semi-solid. In addition, formulation forms include, for example, solutions, suspensions, emulsions, creams,
It can be made into formulations such as emulsions, ointments, gels, liniments, lotions, aerosols, sprays, and sheets made of nonwoven fabric impregnated with drug solutions. Among these, liquids, emulsions, creams, emulsions, ointments, gels, lotions, and sheets are preferred, and creams, emulsions, gels, lotions, and sheets are particularly preferred. In addition, when it contains an oily base and an aqueous base, such as an emulsion, cream, or ointment, it may be a W/O type or an O/W type, but the skin external composition of the present invention may be appropriately increased. The O/W type is more preferable from the viewpoint of ensuring viscosity and the feeling of use (stickiness, spreadability, moist feeling, freshness, penetration feeling, etc.).

[Use applications]
Specifically, when used as a quasi-drug or cosmetic composition for external use, for example,
Basic cosmetics such as lotions, emulsions, gels, creams, serums, sunscreen cosmetics, packs, masks, hand creams, all-in-one gels, all-in-one creams, body lotions, and body creams; as well as facial cleansers, hand soaps, Cleaning cosmetics such as makeup removers, body shampoos, shampoos, conditioners, and treatments; face makeup cosmetics such as foundations, makeup bases, BB creams, and CC creams; lip cosmetics such as lip balms and lip liners; Examples include hair rinses, hair treatments, hair conditioners, hair gels, hair mousses, hair mist, hair lotions, and hair cosmetics such as styling agents. Among these, external compositions for skin are particularly preferred. That is, the external composition of the present invention can be used as a skin external composition for pharmaceuticals, quasi-drugs, or cosmetics. The formulation form of the skin external composition is the same as that of the external skin composition of the present invention. In addition, usable bases or carriers, additives, and active ingredients, as well as preferred ones thereof, are the same as in the case of the external composition of the present invention.

[container]
The skin external composition of the present invention can be used by being stored in a container of an appropriately selected shape and material depending on the purpose and use. Specific containers include, for example, spray type, bottle type, tube type, jar type, dropper type, dispenser type,
Examples include stick types, pouch bags, and chia packs. The skin external composition of the present invention can be used in a preferred state from the viewpoint of ease of removal from the container, and therefore can increase the degree of freedom in designing formulations containing a high concentration of nicotinic acid amide. That is, even a formulation containing nicotinic acid amide at a high concentration can be easily used in a wide variety of containers such as jars, sprays, bottles, tubes, and dispensers.

Examples of the material of the container include polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, and metal (aluminum, etc.). In addition, these materials can be treated with various coatings, combined by mixing, or laminated, taking into account strength, flexibility, weather resistance, or stability of ingredients. , can be used as a container material. Examples of the coating material include epoxy resin and polyamideimide. Among them, polypropylene, polyethylene (HDPE, LDP
It is preferable to use E, LLDPE, etc.), ethylene vinyl alcohol resin, and metal (aluminum, etc.).

[How to use, etc.]
The skin external composition of the present invention can be suitably used for the purposes of promoting blood circulation, anti-inflammation, and promoting ceramide synthesis in anticipation of the physiological activity of nicotinamide. Furthermore, it is expected to have whitening, anti-wrinkle, and anti-aging effects, and is useful as a multifunctional preparation, including as a whitening agent and sunscreen. The skin external composition of the present invention can be divided into one to several times per day depending on the purpose etc.
It can be used in a known or customary manner and dose.

Next, the present invention will be specifically explained using Examples and Test Examples, but the present invention is not limited to the following Examples and Test Examples.

[Test Example 1. Verification test for suppressing viscosity reduction due to heat-1]
Samples having the compositions shown in Table 1 below were prepared. Fill 20 mL of each sample into a glass bottle,
It was stored at 60°C for one week (equivalent to storage for one year at room temperature). Comparative Examples 1-1, 1-
2 and Examples 1-1 to 1-3, the M3 rotor was used, and the other cases used the M2 rotor, and the temperature was 6 r at 25°C.
The measurement was carried out for 1 minute at a rotational speed of pm. Then, the viscosity reduction rate was determined using the following formula. The results are shown in the same Table 1.
<Viscosity reduction rate>
Viscosity reduction rate (%) = (Viscosity before storage - Viscosity after storage) / Viscosity before storage × 100

Comparative Examples 1-1 and 1-2 and Comparative Examples 1-3 and 1-4 show that adding nicotinamide to the water-soluble polysaccharide promotes a decrease in the viscosity of the composition after storage, and the value of the viscosity decrease rate It can be seen that the amount increases. On the other hand, as in Examples 1-1 to 1-3, gellan gum and nicotinic acid amide were further added to polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.
O. ) (8E.O.) (5P.O.), polyethylene methyl glucoside, or PPG-1
When 4-polyglyceryl-2 ether was added, the value of the viscosity reduction rate became smaller than that of Comparative Example 1-2, indicating that the viscosity reduction of the gellan gum-containing composition due to nicotinic acid amide was suppressed.

Similarly, as in Examples 1-4 and 1-5, in addition to agar and nicotinamide, (C)
Even when the component (C) was added, the viscosity reduction rate was smaller than that of Comparative Example 1-4, which did not contain component (C), indicating that the viscosity reduction of the agar-containing composition caused by nicotinic acid amide was suppressed. It has been shown.

In all of Examples 1-1 to 1-5, the usability of the samples after storage was good.

On the other hand, when hydroxyethylcellulose, which is a cellulose (cellulose derivative), is used instead of the water-soluble polysaccharide described in this specification, nicotine The tendency for the viscosity reduction rate to increase with acid amide was the same as with gellan gum and agar. As shown in Comparative Examples 1-7 to 1-9, when hydroxyethyl cellulose was added, the viscosity reduction was not suppressed but rather accelerated.

[Test Example 2. Verification test for suppressing viscosity reduction due to heat-2]
Samples having the compositions shown in Table 2 below were prepared. Fill 20 mL of each sample into a glass bottle,
It was stored at 60°C for one week (equivalent to storage for one year at room temperature). After stabilizing at 25°C, the viscosity of the sample before and after storage was measured using a B-type viscometer (BL type) (model TV-10M, manufactured by Toki Sangyo Co., Ltd.) at 6 rpm at 25°C using an M3 rotor. The measurement was carried out for 1 minute at a rotation speed of . Then, the viscosity reduction rate was determined using the same formula as in Test Example 1. The results are shown in the same Table 2.

Comparative Example 1-2 containing components (A) and (B) but not containing component (C), and Examples 2-1 to 1
0, in all Examples, by adding component (C), the value of the viscosity reduction rate was smaller than that of Comparative Example 1-2, and the viscosity reduction over time of the composition due to heat was suppressed. It was shown that

Furthermore, when comparing Comparative Example 2-1, which contains 5% by mass of nicotinamide as component (B) in addition to component (A), and Example 2-11, which further contains component (C), the (C) component It was shown that by adding nicotinamide, the decrease in viscosity of the composition over time due to heat was suppressed, as in the case of 3% by mass of nicotinamide.

In addition, when component (A) contains a heparin-like substance in addition to gellan gum (Comparative Example 2-2 and Example 2-12), and when it contains xanthan gum in addition to gellan gum (Comparative Example 2-3 and Example 2-13) also showed that by adding each component (C), the decrease in viscosity of the composition over time due to heat was suppressed.

In all of Examples 2-1 to 2-13, the usability of the samples after storage was good.

[Test Example 3. Verification test for suppressing viscosity reduction due to light from a standard light source]
Samples having the compositions shown in Tables 3 and 4 below were prepared. 20 mL of each sample was filled in a glass bottle and irradiated at 25° C. with light from a D65 fluorescent lamp, which is a standard light source specified by the Commission Internationale de l'Eclairage (CIE), at 4500 lx/h until a total of 1.2 million lx was reached. The viscosity of the sample before and after irradiation was measured using a B-type viscometer (BL type) (model TV-10M, manufactured by Toki Sangyo Co., Ltd.).
Using a rotor, measurement was performed for 1 minute at 25° C. and a rotation speed of 6 rpm. Then, the viscosity reduction rate was determined using the following formula. The results are shown in Tables 3 and 4, respectively.
<Viscosity reduction rate>
Viscosity reduction rate (%) = (Viscosity before irradiation - Viscosity after irradiation) / Viscosity before irradiation × 100

In Table 3, when Comparative Example 3-2 containing components (A) and (B) is compared with Examples 3-1 to 3-16 containing component (C), all examples show that (C) ) By adding the component, the value of the viscosity reduction rate became smaller than that of Comparative Example 3-2, indicating that the viscosity reduction of the composition over time due to light mainly composed of visible light was suppressed. .

In addition, in Table 4, in addition to component (A), 5% by mass of nicotinamide was added as component (B).
Comparing cases where nicotinamide is contained (Comparative Example 3-3 and Example 3-17) and cases where nicotinamide is contained at 10% by mass (Comparative Example 3-4 and Example 3-18), component (C) is added. As a result, as in the case where nicotinamide was 3% by mass, it was shown that the decrease in viscosity of the composition over time due to light mainly composed of visible light was suppressed.

In addition, when containing a heparin-like substance in addition to gellan gum as component (A) (Comparative Example 3-5 and Example 3-19), when containing xanthan gum in addition to gellan gum (
The results of Comparative Example 3-6 and Example 3-20) show that the addition of component (C) suppresses the decrease in viscosity of the composition over time due to light mainly composed of visible light. Ta.

In all of Examples 3-1 to 3-20, the usability of the samples after storage was good.

[Test Example 4. Verification test of suppression of viscosity reduction due to ultraviolet light (UV)]
Samples having the compositions shown in Table 5 below were prepared. Fill 20 mL of each sample into a glass bottle,
At 35° C., ultraviolet light was irradiated at an illuminance of 765 W/m 2 for 72 hours using Suntest XLS+ (manufactured by Toyo Seiki Co., Ltd., 1700 W xenon air-cooled lamp light source). At the same time, a sample (control) shielded from light with aluminum foil was also irradiated, and after stabilization at 25°C, the viscosity of both samples was measured using a B-type viscometer (BL type) (model TV-10M, Toki Sangyo Co., Ltd.). Comparative Example 4
-3 to 4 and Example 4-4 use an M4 rotor, and the others use an M3 rotor.
The measurement was carried out at a temperature of 6 rpm for 1 minute. Then, the viscosity reduction rate was determined using the following formula.
The results are shown in the same Table 5.
<Viscosity reduction rate>
Viscosity reduction rate (%) = (control sample viscosity - irradiated sample viscosity) / control sample viscosity × 100

Comparative Example 4-2 containing components (A) and (B) and Example 4 further containing component (C)
Comparing Examples 1 to 3, all examples show that by adding component (C), Comparative Example 4-
The value of the viscosity reduction rate was smaller than that of No. 2, indicating that the viscosity reduction of the composition over time due to ultraviolet light was suppressed.

In addition, when containing alginic acid instead of gellan gum as component (A) (Comparative Example 4
-3, 4 and Example 4-4), when containing pectin (Comparative Example 4-5 and Example 4-5)
) also showed that by adding component (C), the decrease in viscosity of the composition over time due to ultraviolet light was suppressed.

In all of Examples 4-1 to 4-5, the usability of the samples after storage was good.

[Formulation example]
External skin compositions of the present invention (Formulation Examples 1 to 26) were prepared based on the formulations shown in Tables 6 to 31 below.

Claims (5)

A skin external composition containing (A) a water-soluble polysaccharide, (B) 3% by mass or more of nicotinic acid amide, and (C) an amphipathic component. The skin external composition according to claim 1, wherein the content of the component (B) is 3 to 20% by mass. The component (C) is one or more selected from the group consisting of a phosphorylcholine-containing polymer, a divalent carboxylic acid ester, an alkanediol having 5 to 10 carbon atoms, and an alkylene oxide derivative represented by the following chemical formula (I). The skin external composition according to claim 1 or 2, which is:
Z-{O(AO)a(EO)b-(BO)cH}n (I)
(In the formula, n is an integer from 1 to 9;
Z is a hydrogen atom or a group obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms;
AO is an oxyalkylene group having 3 to 4 carbon atoms;
EO is an oxyethylene group;
BO is an oxyalkylene group having 4 carbon atoms;
a, b, and c are the average number of added moles of AO, EO, and BO, respectively, and are each independently from 0 to 200; a, b, and c are never all 0;
AO and EO may be added randomly or in blocks;
When n is 2 or more, a, b, and c may be the same or different;
When Z is a hydrogen atom, n is 1). Any one of claims 1 to 3, wherein the component (A) is one or more selected from the group consisting of gums, heparin-like substances, alginic acids, agar, pectin, pullulan, and mannan. The skin external composition described in . In the chemical formula (I), Z is a hydrogen atom, or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, trimethylolpropane, erythritol, pentaerythritol, alkyl glucoside, diglycerin, xylitol, dipentaerythritol, sorbitol, Inositol, sucrose, trehalose, maltitol or 1 or more carbon atoms
5. The skin external composition according to claim 3, which is a group obtained by removing n hydroxy groups from a 30 hydroxy compound.