JP2020125291A - Antiperspirant composition for scalp - Google Patents

Abstract

To provide an antiperspirant composition for scalp that suppresses sweat from scalp, and suppresses a scalp odor while suppressing influence on skin indigenous bacteria on scalp.SOLUTION: An antiperspirant composition for scalp contains (A) at least one selected from the group consisting of phenolic bactericidal component, quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) antiperspirant component.SELECTED DRAWING: None

Description

The present invention relates to an antiperspirant composition for the scalp.

Body odor is mainly caused by a mixture of sebum and sweat being metabolized by skin-resident bacteria to produce fatty acids and the like. Therefore, conventionally, in order to suppress axillary odors and foot odors, triclosan, benzalkonium chloride and the like, using an external composition containing a bactericidal component that suppresses the growth of skin-resident bacteria, aluminum chloride, etc. It is known to use an external composition containing an antiperspirant component that suppresses the occurrence of

In recent years, an increasing number of people are complaining not only of the armpits and feet but also of the sweat and smell of the head. It is known that most skin-resident bacteria on the scalp are composed of Staphylococcus captis, which is a bacterium belonging to the genus Staphylococcus, unlike the skin at other sites. Is considered to be one of the causes of the odor of the scalp being different from the odor generated from the skin of other parts (Non-Patent Document 1).

Research on head odor, Cosmetic Journal, 28(3):295-298, 1994

However, the present situation is that the research and development of antiperspirant compositions focusing on the properties of the scalp have not yet progressed sufficiently.

As a result of intensive studies in view of the present situation, the present inventors have come to pay attention to the following problems. Since the skin resident bacteria maintain the ecological balance of the skin surface and exert the barrier function, etc., when an external composition containing a bactericidal component is used for the scalp, depending on the type of the bactericidal component, the skin resident bacteria of the scalp may be present. There is a risk that it may upset the ecological balance, and may cause head odors or block the barrier function, resulting in skin diseases. In particular, in addition to the bactericidal component, when using an external composition containing an antiperspirant component that suppresses the generation of sweat on the scalp, depending on the type of each component, against the skin resident bacteria of the scalp, the bactericidal component alone There is a possibility that an additive bactericidal effect that is higher than the bactericidal effect when used in 1. may be generated, and there is a possibility that the ecological balance of skin-resident bacteria of the scalp may be significantly disrupted.

In addition, when the external composition is used for the scalp, there is a concern that the external composition drips on the face or the like and may affect the hairstyle.

The present invention has been made in view of the above problems, and provides a scalp antiperspirant composition capable of suppressing the odor of the scalp while suppressing the generation of sweat and suppressing the effect on the skin resident bacteria of the scalp. The purpose is to

In addition, the present invention has been made in view of the above problems, and another object thereof is to provide a scalp antiperspirant composition that suppresses dripping from the head and has good usability.

The present inventors have conducted extensive studies in view of the above problems, and a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and at least one selected from the group consisting of zinc pyrithione. Surprisingly, by using an antiperspirant composition for the scalp containing an antiperspirant component, it is possible to unexpectedly suppress the generation of sweat, easily maintain the ecological balance of skin-resident bacteria of the scalp, and eliminate the odor of the scalp. It was found that the remarkable effect of being able to be suppressed is exhibited. Further, they have found that the present invention has a remarkable effect of suppressing dripping from the head and having good usability, and thus completed the present invention.

That is, the present invention relates to the following inventions.
[1] A scalp containing at least one selected from the group consisting of (A) a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione; and (B) an antiperspirant component. Antiperspirant composition.
[2] The antiperspirant composition for scalp according to [1], wherein the phenolic bactericidal component is at least one selected from the group consisting of isopropylmethylphenol, triclosan, and trichlorocarbanilide.
[3] The quaternary ammonium salt is at least one selected from the group consisting of benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, and cetyltrimethylammonium bromide, [1] Alternatively, the antiperspirant composition for scalp according to [2].
[4] The component (B) is at least one selected from the group consisting of chlorohydroxyaluminum, aluminum chloride, aluminum zirconium complex salt, allantoin chlorohydroxyaluminum, and zinc paraphenolsulfonate, [1] to The antiperspirant composition for scalp according to any one of [3].
[5] The antiperspirant composition for scalp according to any one of [1] to [4], further containing (C) powder.
[6] The antiperspirant composition for scalp according to any one of [1] to [5], which further contains (D) a cooling component.
[7] The antiperspirant composition for scalp according to any one of [1] to [6], which is used for controlling skin-resident bacteria on the scalp.
[8] Using (A) at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component, A method for controlling skin-resident bacteria on the scalp.

According to the present invention, it is possible to provide a scalp antiperspirant composition that can suppress the generation of sweat, can easily maintain the balance of skin-resident bacteria on the scalp, and can suppress the odor of the scalp.

Further, according to the present invention, it is possible to provide a scalp antiperspirant composition having good usability by suppressing dripping from the head.

FIG. 1 is a diagram showing the results of evaluating the metabolic inhibitory effect of bacteria, as described in Examples described later. FIG. 2 is a diagram showing the results of evaluating the metabolic inhibitory effect of bacteria, as described in Examples described later.

Hereinafter, embodiments of the present invention will be described in detail. However, the present invention is not limited to the following embodiments.

<Antiperspirant composition for scalp>
The present invention contains (A) at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component. An antiperspirant composition for the scalp, which further contains (C) powder, (D) cooling component, or other components, if necessary.

<(A) component>
The component (A) is a specific bactericidal component, and is at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione. Examples of the phenolic bactericidal component include isopropylmethylphenol, triclosan, trichlorocarbanilide and the like. Examples of the quaternary ammonium salt include benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide and the like. Among them, from the viewpoint of further enhancing the effect of the present invention, preferably, isopropylmethylphenol, piroctone olamine, benzalkonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, glycyrrhetinic acid, zinc pyrithione. Is. More preferred are isopropylmethylphenol, piroctone olamine, benzalkonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, glycyrrhetinic acid and zinc pyrithione. Even more preferred are isopropylmethylphenol, benzalkonium chloride, cetyltrimethylammonium bromide, and glycyrrhetinic acid. These may be used alone or in combination of two or more. From the viewpoint of further enhancing the effect of the present invention, preferred combinations include, for example, at least isopropylmethylphenol, piroctone olamine, benzalkonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, and glycyrrhetin. Acid, a combination with one or more selected from the group consisting of zinc pyrithione, or at least containing benzalkonium chloride, piroctone olamine, isopropylmethylphenol, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethyl bromide Ammonium, glycyrrhetinic acid, a combination with one or more selected from the group consisting of zinc pyrithione is preferred, isopropylmethylphenol and cetyltrimethylammonium bromide, isopropylmethylphenol and glycyrrhetinic acid, isopropylmethylphenol and cetylpyridinium chloride, isopropyl More preferred are methylphenol and benzalkonium chloride, benzalkonium chloride and cetyltrimethylammonium bromide, benzalkonium chloride and glycyrrhetinic acid, benzalkonium chloride and cetylpyridinium chloride, and isopropylmethylphenol and cetyltrimethylammonium bromide, isopropyl. Methylphenol and glycyrrhetinic acid, isopropylmethylphenol and benzalkonium chloride, benzalkonium chloride and cetyltrimethylammonium bromide, benzalkonium chloride and glycyrrhetinic acid, benzalkonium chloride and cetylpyridinium chloride are more preferred, and isopropylmethylphenol and Even more preferred is benzalkonium chloride.

The content of the component (A) is not particularly limited, but from the viewpoint of further enhancing the effect of the present invention, for example, 0.001 w/w% or more, preferably 0.005 w/w%, relative to the total amount of the composition. The above is more preferably 0.01 w/w% or more. The content of the component (A) is not particularly limited, but is, for example, 0.2 w/w% or less, preferably 0.15 w/w% or less, and more preferably 0.1 w/w based on the total amount of the composition. w% or less.

When the scalp antiperspirant composition containing the component (A) is an aerosol, the content of the component (A) exemplified above is the content with respect to the total amount of the composition excluding the propellant.

<(B) component>
The component (B) is an antiperspirant component that converges or blocks the sweat glands to suppress the generation of sweat, and examples thereof include aluminum compounds, zirconium compounds, zinc compounds, aluminum and zirconium composite compounds, and alum. Examples of the aluminum compound include aluminum chloride, aluminum sulfate, aluminum potassium sulfate, ammonium aluminum sulfate, aluminum acetate, chlorohydroxyaluminum, allantoin chlorohydroxyaluminum, bromohydroxyaluminum and the like. Examples of the zirconium compound include zirconium oxide and chlorohydroxyzirconium. Examples of the zinc compound include zinc paraphenol sulfonate and zinc oxide. Examples of the aluminum-zirconium composite compound include aluminum-zirconium composite salts. Among them, from the viewpoint of further enhancing the effect of the present invention, chlorohydroxyaluminum, aluminum zirconium complex salt, zinc paraphenolsulfonate, and alum are preferable. More preferred are chlorohydroxyaluminum, zinc paraphenolsulfonate, and alum. Even more preferably, they are chlorohydroxyaluminum and zinc paraphenolsulfonate. These may be used alone or in combination of two or more.

The content of the component (B) is not particularly limited, but from the viewpoint of further enhancing the effect of the present invention, for example, 0.01 w/w% or more, preferably 0.05 w/w% with respect to the total amount of the composition. The above is more preferably 0.1 w/w% or more. The content of the (B) antiperspirant component is not particularly limited, but is, for example, 30 w/w% or less, preferably 25 w/w% or less, and more preferably 15 w/w% or less with respect to the total amount of the composition. is there.

When the component (B) is an aluminum compound or a zirconium compound, the content thereof is not particularly limited, but from the viewpoint of further enhancing the effect of the present invention, for example, 0.1 w/w% or more based on the total amount of the composition. , Preferably 0.5 w/w% or more, more preferably 1 w/w% or more. When the component (B) is an aluminum compound or a zirconium compound, its content is not particularly limited, but is 30 w/w% or less, preferably 25 w/w% or less, more preferably 15 w/w% or less.

When the component (B) is a zinc compound, its content is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention, for example, 0.01 w/w% or more, preferably 0.01 w/w% or more, relative to the total amount of the composition. It is 0.05 w/w% or more, more preferably 0.1 w/w% or more. When the component (B) is a zinc compound, its content is not particularly limited, but is, for example, 10 w/w% or less, preferably 5 w/w% or less, and more preferably 3 w/w based on the total amount of the composition. w% or less.

When the scalp antiperspirant composition containing the component (B) is an aerosol agent, its content is not particularly limited, but from the viewpoint of further enhancing the effect of the present invention, it is relative to the total amount of the composition excluding the propellant. For example, it is 0.01 w/w% or more, preferably 0.05 w/w% or more, and more preferably 0.1 w/w% or more. The content of the component (B) in the aerosol agent is not particularly limited, but is, for example, 5 w/w% or less, preferably 4 w/w% or less, and more preferably 3 w based on the total amount of the composition excluding the propellant. /W% or less.

The ratio of the content of the component (B) to the content of the component (A) is not particularly limited, but from the viewpoint of further enhancing the effect of the present invention, for example, per 1 part by weight of the content of the component (A), The content of the component (B) is 0.1 to 30000 parts by weight, preferably 0.3 to 5000 parts by weight, more preferably 1 to 1500 parts by weight.

<(C) powder>
From the viewpoint of further enhancing the usability of the scalp antiperspirant composition of the present invention, it is preferable to further contain (C) powder. Examples of the powder (C) include organic powder and inorganic powder. As the organic powder, for example, corn starch, rice starch, tapioca starch, potato starch, wheat starch, siliconate modified starch, sodium octenyl succinate starch, starch octenyl succinate aluminum, polyurethane, nylon powder, polystyrene resin, methylsiloxane reticulated heavy Examples thereof include coalesce, polymethylmethacrylate resin, melamine resin, phenol resin, fluorine resin, cellulose and silicone resin. Examples of polyurethane include (HDI/trimethylolhexyl lactone) crosspolymer. Examples of the polymethylmethacrylate-based resin include methylmethacrylate crosspolymer and polymethylmethacrylate. Examples of the silicone resin include (dimethicone/vinyl dimethicone) crosspolymer, (diphenyldimethicone/vinyldiphenyldimethicone/silsesquioxane) crosspolymer, (vinyldimethicone/methicone silsesquioxane) crosspolymer, and the like. Examples of the inorganic powder include sericite, mica, kaolin, red iron oxide, clay, bentonite, silica (anhydrous silicic acid/hydrous silicon dioxide), talc, and those whose surface is treated with silicone or the like. Among them, from the viewpoint of further enhancing the effect of the present invention and the feeling of use, corn starch, rice starch, tapioca starch, potato starch, wheat starch, siliconate modified starch, sodium octenyl succinate starch, starch octenyl succinate aluminum, and polyurethane are preferable. , Nylon powder, polystyrene resin, methylsiloxane network polymer, polymethylmethacrylate resin, cellulose, silica (silicic anhydride/hydrous silicon dioxide), talc, silicone surface treated silica, silicone surface treated talc, silicone resin. .. More preferably, corn starch, sodium starch octenyl succinate, aluminum starch octenyl succinate, polyurethane, nylon powder, methyl siloxane network polymer, polymethyl methacrylate resin, silica (silicic anhydride/hydrous silicon dioxide), talc, silicone surface Treated silica, silicone surface treated talc, and silicone resin. Even more preferably, corn starch, sodium starch octenyl succinate, starch aluminum octenyl succinate, (HDI/trimethylolhexyl lactone) crosspolymer, nylon powder, methylsiloxane network polymer, methylmethacrylate crosspolymer, polymethylmethacrylate, silica. (Silicic anhydride/hydrous silicon dioxide), talc, (dimethicone/vinyl dimethicone) crosspolymer, (diphenyldimethicone/vinyldiphenyldimethicone/silsesquioxane) crosspolymer, (vinyldimethicone/methicone silsesquioxane) crosspolymer, Silicone surface treated silica and silicone surface treated talc. Particularly preferred are corn starch, silica (silicic anhydride/hydrous silicon dioxide), and talc. These may be used alone or in combination of two or more.

The shape of the (C) powder is not particularly limited, and examples thereof include spherical, plate-like, granular, and needle-like shapes.

(C) Commercially available powders include, for example, KSP-102, KSP-300, KMP-590, KMP-591, KSG-15 (all manufactured by Shin-Etsu Chemical Co., Ltd.), and SP-500 (manufactured by Toray). , Fine Pearl (Sumitomo Chemical Co., Ltd.), Techpolymer SB, Techpolymer MB (above, registered trademark, Sekisui Plastics Co., Ltd.), Fine Powder SGP, Fine Powder MP (above, Soken Chemical Industry Co., Ltd.), Tospearl 145 , Tospearl 2000B (above, registered trademark, manufactured by Toshiba Silicone Co., Ltd.), BY29-129, Trefil (registered trademark, manufactured by Toray Dow Corning Silicone Co., Ltd.), Matsumoto Microsphere M (manufactured by Matsumoto Yushi-Seiyaku Co., Ltd.), Japanese Pharmacopoeia Corn starch ST-C (manufactured by Nitto Chemical Co., Ltd.), corn starch (manufactured by Matsutani Chemical Co., Ltd.), dry flow PC (manufactured by Akzo Nobel), silica beads SB-300, SA-SB-300, SA-talc JA- 13R, SA-talc JA-46R, SA-talc JA-68R (above, manufactured by Miyoshi Kasei Co., Ltd.), Aerosil 200 (registered trademark, manufactured by Nippon Aerosil Co., Ltd.), talc JA-46R, talc MMR (above, manufactured by Asada Milling Co., Ltd. ), GANTZ PEARL GM-0610, GANTZ PEARL GMX-0810, GANTZ PEARL GPA-550 (above, registered trademark, manufactured by Aika Kogyo Co., Ltd.), PLASTIC POWDER D-400, PLASTIC POWDER D-400HP, PLASTIC POWDER D-800 (or more. Manufactured by Tohoku Pigment Co., Ltd.) and the like.

The content of the (C) powder is not particularly limited, but from the viewpoint of further enhancing the effect of the present invention and the feeling of use, it is, for example, 0.1 w/w% or more, preferably 0. It is 3 w/w% or more, more preferably 0.5 w/w% or more. The content of the (C) powder is not particularly limited, but is, for example, 30 w/w% or less, preferably 20 w/w% or less, more preferably 10 w/w% or less with respect to the total amount of the composition. ..

The content of the (C) powder is not particularly limited, but is selected according to the dosage form from the viewpoint of further enhancing the effects and the feeling of use of the present invention. In the case of an aerosol agent, the amount is, for example, 1 w/w% or more, preferably 3 w/w% or more, more preferably 5 w/w% or more with respect to the total amount of the composition excluding the propellant. The content of the (C) powder is not particularly limited, but is, for example, 30 w/w% or less, preferably 25 w/w% or less, and more preferably 20 w/w with respect to the total amount of the composition excluding the propellant. % Or less.

The content of the (C) powder is not particularly limited, but in the case of liquid agents such as roll-on type and mist type, emulsions, gels, and creams, for example, 0.1 w/w% or more based on the total amount of the composition, It is preferably 0.3 w/w% or more, more preferably 0.5 w/w% or more. The content of the (C) powder is not particularly limited, but is, for example, 20 w/w% or less, preferably 15 w/w% or less, and more preferably 10 w/w% or less with respect to the total amount of the composition. ..

The ratio of the content of the component (C) to the content of the component (A) is not particularly limited, but from the viewpoint of further enhancing the effect and the feeling of use of the present invention, for example, the content of the component (A) is 1% by weight. The content of the component (C) is 1 to 30000 parts by weight, preferably 2 to 5000 parts by weight, and more preferably 5 to 2000 parts by weight per part.

The ratio of the content of the component (C) to the content of the component (B) is not particularly limited, but from the viewpoint of further enhancing the effect and usability of the present invention, for example, the content of the component (B) is 1% by weight. The content of the component (C) is 0.003 to 3000 parts by weight, preferably 0.01 to 500 parts by weight, and more preferably 0.030 to 200 parts by weight per part.

The average primary particle diameter of the (C) powder is not particularly limited, but is, for example, 0.1 μm or more, preferably 1 μm or more, and more preferably 5 μm or more, from the viewpoint of further enhancing the effect and usability of the present invention. .. The average primary particle diameter of the (C) powder is not particularly limited, but is, for example, 30 μm or less, preferably 20 μm or less, more preferably 15 μm or less. The average primary particle size is measured by a laser diffraction scattering method.

<(D) Cooling ingredient>
From the viewpoint of further enhancing the feeling of use of the scalp antiperspirant composition of the present invention, it is preferable to further contain (D) a cooling component. Examples of the cooling component (D) include l-menthol, dl-menthol, l-menthyl glyceryl ether, l-menthyl lactate, menthyl salicylate, menthyl 3-hydroxybutyrate, mentoxypropanediol, dl-camphor, chlorobutanol. , Essential oils such as borneol, geraniol, cineole, limonene, eugenol, eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose oil, and turpentine oil. Of these, 1-menthol, 1-menthyl glyceryl ether, 1-menthyl lactate, eucalyptus oil, peppermint oil, and chlorobutanol are preferable from the viewpoint of further enhancing the effect and usability of the present invention. More preferred are l-menthol, l-menthyl glyceryl ether, eucalyptus oil and peppermint oil. These may be used alone or in combination of two or more.

The content of the component (D) is not particularly limited, but from the viewpoint of further enhancing the effect and usability of the present invention, for example, 0.01 w/w% or more, preferably 0.05 w, relative to the total amount of the composition. /W% or more, more preferably 0.1 w/w% or more. The content of the component (D) is not particularly limited, but is, for example, 5 w/w% or less, preferably 3 w/w% or less, and more preferably 1 w/w% or less with respect to the total amount of the composition.

When the scalp antiperspirant composition containing the component (D) is an aerosol, the content of the component (D) exemplified above is the content with respect to the total amount of the composition excluding the propellant.

The ratio of the content of the component (D) to the content of the component (A) is not particularly limited, but from the viewpoint of further enhancing the effect and the feeling of use of the present invention, for example, the content of the component (A) is 1 wt. The content of the component (D) is 0.05 to 5000 parts by weight, preferably 0.3 to 600 parts by weight, and more preferably 1 to 100 parts by weight per part.

The ratio of the content of the component (D) to the content of the component (B) is not particularly limited, but from the viewpoint of further enhancing the effect and the feeling of use of the present invention, for example, the content of the component (B) is 1% by weight. The content of the component (D) is 0.0003 to 500 parts by weight, preferably 0.002 to 60 parts by weight, and more preferably 0.006 to 10 parts by weight per part.

<Other ingredients>
The antiperspirant composition for scalp of the present invention may contain components (other components) other than the components (A) to (D) described above within a range not impairing the effects of the present invention. For example, bases or carriers, surfactants, oils, thickeners, preservatives, antioxidants, preservatives, chelating agents, pH adjusters, stabilizers, solubilizers, buffers, dispersants, colorants. , Moisturizing ingredients, conditioning agents, blood circulation promoters, ultraviolet absorbing ingredients, ultraviolet scattering ingredients, anti-inflammatory agents, vitamins, organic acids, peptides or their derivatives, amino acids or their derivatives, washing ingredients, keratin softening ingredients, cell activating ingredients , An anti-aging component, a scalp hair care component, an anti-glycation component and the like can be added. The other components may be used alone or in combination of two or more.

<Base or carrier>
Examples of the base or carrier include liquid paraffin, squalane, gelled hydrocarbon (plastibase, etc.), ozokerite, α-olefin oligomer, light liquid paraffin, and other hydrocarbons; methyl polysiloxane, cross-linked methyl polysiloxane, highly polymerized. Methyl polysiloxane, cyclic silicone, alkyl modified silicone, cross-linked alkyl modified silicone, amino modified silicone, polyether modified silicone, polyglycerin modified silicone, cross-linked polyether modified silicone, cross-linked alkyl polyether modified silicone, silicone/alkyl chain Silicone oils such as co-modified polyether-modified silicone, silicone/alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, silicone resin; polyethylene glycol; dioxane; myristin Esters such as isopropyl acid ester, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate, glyceryl tri(caprylic/capric acid); lower grades such as ethanol and isopropanol Alcohols; glycol ethers such as diethylene glycol monomethyl ether and diethylene glycol monoethyl ether; polyhydric alcohols such as polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin and isoprene glycol; water-based bases such as water.

<Surfactant>
Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, penta-2-ethylhexyl diglycerol sorbitan, and tetra-2-ethylhexyl diglycerol sorbitan. Sorbitan fatty acid esters; lipophilic glycerin fatty acid esters such as glyceryl monostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor Hydrogenated castor oil derivatives such as oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80 (HCO-80); polylauryl acid polyoxyethylene (20) sorbitan (Polysorbate 20), polyoxyethylene (80) sorbitan monolaurate, polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), polyoxyisostearate Polyoxyethylene sorbitan fatty acid esters such as ethylene (20) sorbitan; polyoxyethylene fatty acid glyceryls such as polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ethers; alkyl glucosides; polyoxyalkylene alkyls such as polyoxyethylene cetyl ether Ethers; polyoxyethylene polyoxypropylene decyl tetradecyl ether and other polyoxyethylene polyoxypropylene alkyl ethers; polyoxyethylene lauryl alcohol ether and other nonionic surfactants; stearylamine, oleylamine and other amines; PEG-11 Polyether-modified silicones such as methyl ether dimethicone, PEG-10 dimethicone, PEG/PPG-19/19 dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone; lauryl PEG-9 polydimethylsiloxyethyl dimethicone, cetyl dimethicone copolyol, and other poly Ether alkyl co-modified silicone; polyglycerin modified silicone; polyglycerin alkyl co-modified silicone; silicone type surfactant such as cross-linking silicone; laurate, palmitate, cocoyl glutamate, coconut oil methyl alanine salt, Acyl methyl taurine salt, higher alkyl sulfate ester salt such as sodium lauryl sulfate; POE-alkyl ether sulfate ester salt such as sodium lauryl sulfate; N-acyl sarcosinic acid such as sodium lauroyl sarcosine; POE-stearyl ether phosphate, potassium cetyl phosphate , Cetyl phosphate; sulfosuccinates such as sodium di-2-ethylhexyl sulfosuccinate; alkylbenzene sulfonates; higher fatty acid ester sulfate ester salts; monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, N-myristoyl-L -Acyl glutamate such as monosodium glutamate; POE-alkyl ether carboxylic acid; POE-alkyl allyl ether carboxylate; α-olefin sulfonate; anionic surfactant such as higher fatty acid ester sulfonate, lauryl diaminoethyl Glycine salt; coconut oil fatty acid betaine salt; carbobetaine; sulfobetaine; imidazolinium betaine; and amphoteric surfactants such as amidobetaine; naturally derived interfaces such as lecithin, hydrogenated lecithin, saponin, sodium surfactin, and bile acid. Activator etc. are mentioned.

<Oil>
Examples of the oil component include natural animal and vegetable oils and fats, waxes, hydrocarbon oils, ester oils, silicone oils, higher alcohols, higher fatty acids and the like.

<Natural animal and vegetable oils and fats>
Examples of natural animal and vegetable oils and fats include avocado oil, linseed oil, almond oil, olive oil, cocoa oil, wheat germ oil, sesame oil, rice germ oil, rice bran oil, safflower oil, soybean oil, evening primrose oil, camellia oil, corn. Oil, rapeseed oil, horse fat, persic oil, palm oil, palm kernel oil, castor oil, sunflower oil, lard, grape oil, jojoba oil, macadamia nut oil, kukui nut oil, hazelnut oil, cottonseed oil, mokuro, palm oil, hardened oil Examples include coconut oil, peanut oil, lanolin, egg yolk oil, rosehip oil, and shea butter.

<wax>
Examples of the waxes include jojoba oil, miu wax, candelilla wax, rice bran wax, cotton wax, carnauba wax, lanolin and the like.

<Hydrocarbon oil>
As the hydrocarbon oil, for example, paraffin hydrocarbons, olefin hydrocarbons are used, for example, squalane, squalene, ceresin, paraffin, pristane, microcrystalline wax, liquid paraffin, liquid isoparaffin, petrolatum, polybutene, polyethylene powder, Examples thereof include gelled hydrocarbon, ozokerite, α-olefin oligomer, light liquid paraffin, and light iso liquid paraffin.

<Ester oil>
As the ester oil, for example, synthetic esters, esters of higher alcohols and higher fatty acids are used, and examples thereof include diisopropyl adipate, diisobutyl adipate, 2-hexyldecyl adipate, and di-2-heptylundecyl adipate. , Isostearyl isostearate, trimethylolpropane triisostearate, isononyl isononanoate, isotridecyl isononanoate, cetyl 2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, Glyceryl tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, ethyl oleate, cetyl octanoate, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, 2-ethylhexyl succinate. , Isocetyl stearate, butyl stearate, diethyl sebacate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, tetradecyl lactate, isopropyl myristate, octyldodecyl myristate, myristyl myristate, myristyl myristate, palmitic acid Octyl, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, isopropyl palmitate, cholesteryl 12-hydroxystearate, phytosteryl oleate, diisostearyl malate, paramethoxycinnamic acid ester, pentaerythritol tetrarosinate, cyclohexane. Examples thereof include bisethoxydiglycol-1,4-dicarboxylate, 2-ethylhexyl succinate, diethoxyethyl succinate, triethyl citrate, and decaglyceryl (eicosanedioic acid/tetradecanedioic acid).

<Silicone oil>
Examples of the silicone oil include dimethylpolysiloxane, highly polymerized methylpolysiloxane; phenyl-modified silicone such as methylphenylpolysiloxane; methylhydrogenpolysiloxane; octamethylcyclotetrasiloxane, octamethylcyclopentasiloxane, decamethylcyclohexasiloxane. Cyclic silicones such as; Cross-linked methyl polysiloxane; Methyl hydrogen polysiloxane, methyl trimethicone, dimethiconol, dimethiconol crosspolymer; Higher alkoxy modified silicone such as stearoxy silicone; Alkyl modified silicone such as caprylyl methicone; Higher fatty acid ester modified Silicone etc. are mentioned.

<Higher alcohol>
Examples of higher alcohols include higher alcohols having 12 to 22 carbon atoms and sterols. Among them, linear saturated alcohols such as lauryl alcohol, myristyl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol and behenyl alcohol; unsaturated alcohols such as oleyl alcohol and ceracyl alcohol; or hexyldecanol, iso Examples include branched alcohols such as stearyl alcohol, octyldodecanol, decyltetradecanol, lanolin alcohol, and isostearyl glyceryl ether; and phytosterols and cholesterol. Among them, preferably, one or more kinds selected from cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, oleyl alcohol, isostearyl alcohol, octyldodecanol, lanolin alcohol, isostearyl glyceryl ether, phytosterol, cholesterol are combined. Preference is given to using.

<Higher fatty acid>
As the higher fatty acid, for example, a saturated or unsaturated linear or branched fatty acid having 12 to 22 carbon atoms can be used, and lauric acid, myristic acid, palmitic acid, stearic acid, margaric acid, arachidonic acid, or Linear saturated fatty acid such as behenic acid; unsaturated fatty acid such as oleic acid, linoleic acid, linolenic acid, arachidonic acid, palmitoleic acid, eicosapentaenoic acid, paxenoic acid or docosahexaenoic acid; or branched such as isostearic acid or lanolin fatty acid Fatty acid, 12-hydroxystearic acid and the like. Among them, preferably, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, isostearic acid, and lanolin fatty acid are used in combination or in combination of two or more. preferable.

<Thickener>
Examples of the thickener include guar gum, locust bean gum, carrageenan, xanthan gum, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydrophobized hydroxypropylmethylcellulose, pectin, pullulan, agar, sodium alginate, Propylene glycol alginate, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl methacrylate acrylate copolymer, polyethylene glycol, (hydroxyethyl acrylate/acryloyldimethyltaurine Na) copolymer, (acryloyldimethyltaurine ammonium/vinylpyrrolidone) copolymer, etc. Is mentioned.

<Antioxidant>
Examples of the antioxidant include dibutylhydroxytoluene (BHT), butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride, tocopherol, and tocopherol acetate.

<Preservative or preservative>
Examples of the preservative or preservative include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and paraoxybenzoate. Examples thereof include benzyl benzoate, methyl paraoxybenzoate, phenoxyethanol, sorbic acid, chlorobutanol, benzyl alcohol, phenethyl alcohol, capryl hydroxamic acid, methylisothiazoline and butylcarbamate propynyl iodide.

<Chelating agent>
Examples of the chelating agent include EDTA.disodium salt, EDTA.calcium.disodium salt, polyphosphoric acid, metaphosphoric acid and the like.

<pH adjuster>
Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, hydroxide). Sodium), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.) and the like.

<Stabilizer>
Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.

<Dissolution aid>
Examples of the solubilizing agent include polyhydric alcohols such as polyethylene glycol and propylene glycol, sugar alcohols such as D-mannitol, benzyl benzoate, ethanol, isopropanol, trisaminomethane, cholesterol, triethanolamine, sodium carbonate and citric acid. Examples include sodium.

<Buffer>
Examples of the buffering agent include buffer solutions of phosphate, acetate, carbonate, citrate and the like.

<Dispersant>
Examples of the dispersant include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinylpyrrolidone, methyl vinyl ether/maleic anhydride cross-linked copolymer, organic acid and the like.

<Colorant>
Examples of the colorant include inorganic pigments and natural dyes.

<Moisturizing ingredient>
Examples of the moisturizing component include polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, polyethylene glycol and diglycerin; PEG/PPG/polybutylene glycol-8/6/3 glycerin, PPG-17 buttes- 17, polyhydric alcohol derivatives such as PPG-24 glycereth-24; sugars such as glycosyltrehalose, trehalose, sorbitol, xylitol, oligosaccharides, glyceryl glucoside; hyaluronic acids (sodium hyaluronate, low molecular weight hyaluronic acid, zinc hyaluronate, acetyl) Hyaluronic acid, cationized hyaluronic acid and other hyaluronic acid derivatives), heparin analogues, macromolecular compounds such as sodium chondroitin sulfate, collagen, elastin, keratin, chitin, chitosan; amino acids such as glycine, aspartic acid, arginine and their derivatives Natural moisturizing factors such as sodium lactate, urea, sodium pyrrolidonecarboxylate; lipids such as ceramide, glucosylceramide, cholesterol, phytosterol, cholesterol derivative phospholipids; chamomile extract, hamamelis extract, tea extract, green tea extract, perilla extract, sage extract, seaweed Examples thereof include plant extracts such as extracts, Neubara extract, peony extract, mugwort extract, aloe extract, sardine extract, and cucumber extract.

<Conditioning agent>
Examples of the conditioning agent include cationized cellulose, cationized starch, cationized fenugreek gum, cationized guar gum, cationized tara gum, cationized locust bean gum, cationized xanthan gum, diallyl quaternary ammonium salt/acrylamide copolymer, polyquaternium. , Vinylimidazolium trichloride/vinylpyrrolidone copolymer, hydroxyethylcellulose/dimethyldiallylammonium chloride copolymer, vinylpyrrolidone/quaternized dimethylaminoethylmethacrylate copolymer, polyvinylpyrrolidone/alkylaminoacrylate copolymer, polyvinylpyrrolidone /Alkylaminoacrylate/vinylcaprolactam copolymer, vinylpyrrolidone/methacrylamidopropyltrimethylammonium chloride copolymer, alkylacrylamide/acrylate/alkylaminoalkylacrylamide/polyethylene glycol methacrylate copolymer, adipic acid/dimethylaminohydroxypropylethylenetriamine Examples thereof include copolymers.

<Blood circulation promoter>
Examples of the blood circulation promoter include acetylcholine, ictamol, caffeine, capsaicin, cantharisin tincture, gamma oryzanol, ginger oriental tincture, zingerone, cepharantin, cembly extract, tannic acid, capsicum tincture, trazoline, glucosyl hesperidin, hesperidin, dl acetate. -Α-tocopherol, nicotinic acid tocopherol, nicotinic acid benzyl ester, ginseng extract, carrot extract, clove extract, chimpanzee extract, Japanese quince extract, ginger extract, ginger extract, ginseng extract, button extract, carrot extract, hypericum extract, cinnamon extract. And so on.

<Ultraviolet absorbing component>
As the ultraviolet absorbing component, octyltriazone, hexyl diethylaminohydroxybenzoylbenzoate, octyl dimethoxybenzylidenedioxoimidazolidinepropionate, 2-ethylhexyl paramethoxycinnamate, t-butylmethoxydibenzoylmethane, phenylbenzimidazole sulfonic acid, Examples include octyl methoxycinnamate, ethylhexyl methoxycinnamate, octocrylene, dimethicodiethylbenzalmalonate, and the like.

<Ultraviolet scattering component>
As the ultraviolet scattering component, for example, hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, zinc oxide, zirconium oxide, cerium oxide, titanium oxide, iron oxide, inorganic compounds such as anhydrous silicic acid, their inorganic Compounds coated with hydrous silicic acid, aluminum hydroxide, inorganic powders such as mica and talc, or compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene and nylon, and silicone oil and fatty acid aluminum salts. And the like.

<Anti-inflammatory agent>
As the anti-inflammatory agent, for example, either a steroidal anti-inflammatory agent or a non-steroidal anti-inflammatory agent can be used. Examples thereof include, but are not limited to, allantoin, glycyrrhizic acid or a salt thereof, steroids such as prodnisolone valerate acetate or hydrocortisone, ufenamate, bufexamac, ibuprofen piconol, glycol salicylate, and tranexamic acid. Furthermore, for example, indomethacin, diclofenac, piroxicam, epsilon-aminocaproic acid, berberine, lysozyme, azulene, and pharmaceutically acceptable salts thereof, plant-derived components (e.g., comfrey, auren, dokudami, chlorella, ethnic leaf, (Ingredients derived from extracts such as Yukinoshita, Hikiokoshi, Ogon, Kawamura Artemisia, Perilla, ginseng root, sage, hawthorn, clove, neem leaf, Hyogi, peach leaf, cherry leaf, artichoke, seaweed, tea, etc.) are exemplified. Preferably, allantoin, tranexamic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, epsilon-aminocaproic acid, azulene, and a combination thereof with one or more selected from derivatives thereof, more preferably allantoin, tranexamic acid, glycyrrhizic acid It is a combination of one or more selected from dipotassium and epsilon-aminocaproic acid.

<Vitamins>
Examples of vitamins include vitamin Es such as dl-α-tocopherol, dl-α-tocopherol acetate acetate, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate; riboflavin, flavin mononucleotide, flavin adenine. Vitamin B2s such as dinucleotides, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium salt, riboflavin tetranicotinate; nicotinic acid, nicotinic acid amide, nicotinic acid dl-α-tocopherol, benzyl nicotinate , Nicotinic acid such as methyl nicotinate, β-butoxyethyl nicotinate, and 1-(4-methylphenyl)ethyl nicotinate; ascorbogen-A, ascorbyl stearate, ascorbyl palmitate, dipalmitate L-ascorbyl. , Ascorbyl tetraisopalmitate, ascorbyl palmitate trisodium phosphate, ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbate glucoside, 2-O-ethylascorbine Vitamin Cs such as acids, 3-O-ethylascorbic acid, glycerylascorbic acid, bisglycerylascorbic acid, alkylglycerylascorbic acid; vitamin Ds such as methylhesperidin, ergocalciferol, cholecalciferol; phylloquinone, farnoquinone, etc. Vitamin Ks, γ-oryzanol, dibenzoylthiamine, dibenzoylthiamine hydrochloride; Vitamin B1s such as thiamine and salts thereof (eg, dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine diphosphate); hydrochloric acid Vitamin B6s such as pyridoxine, pyridoxine acetate, pyridoxal hydrochloride, pyridoxal hydrochloride, pyridoxamine hydrochloride, pyridoxamine hydrochloride; vitamin B12s such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin; folic acids such as folic acid and pteroylglutamic acid; retinol, Retinol derivatives such as retinol acetate, retinol palmitate, retinol propionate and retinol linoleate, vitamins A such as retinal, retinoic acid and tocopheryl retinoate; Vitamin A; Pantothenic Acid, Calcium Pantothenate, Pantothenyl Alcohol (Panthenol), Pantothenic Acids such as D-Panthesin, D-Pantethine, Coenzyme A, Pantothenyl Ethyl Ether; Biotins such as Biotin, Bioticin; Carnitine , Ferulic acid, α-lipoic acid, orotic acid, γ-oryzanol, pyrroloquinoline quinone, glucosyl hesperidin, and ubiquinone.

<Organic acid>
Examples of the organic acid include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, malonic acid, maleic acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytin. Examples thereof include acids, tartaric acid, acetic acid, lactic acid, pantothenic acid, alginic acid, ascorbic acid, benzoic acid, adipic acid, glutamic acid, azelaic acid and salts thereof. Examples of the salt include salts of mineral acids such as sulfuric acid, hydrochloric acid or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts, Examples thereof include basic amino acid salts and amine salts such as triethanolamine. Among them, gluconic acid, citric acid, glutamic acid, succinic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, lactic acid, and a combination thereof with one or more selected from salts thereof are preferable, and gluconic acid, A combination with one or more selected from citric acid, glutamic acid, succinic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, lactic acid and salts thereof is more preferable.

<Peptide or derivative thereof>
Examples of the peptide or its derivative include keratin-degrading peptide, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, succinylated atelocollagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride. Degraded collagen, elastin degrading peptide, conchiolin degrading peptide, hydrolyzing conchiolin, silk protein degrading peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean protein degrading peptide, hydrolyzed soybean protein, wheat protein, wheat protein degrading peptide, hydrolysis Examples include wheat proteins, casein-degrading peptides, acylated peptides (palmitoyl oligopeptides, palmitoyl pentapeptides, palmitoyl tetrapeptides, etc.) and the like.

<Amino acid or its derivative>
Examples of the amino acid or its derivative include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine. , Methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, sodium N-stearoyl-L-glutamate and the like.

<Cleaning ingredients>
As the cleaning component, an alkali metal salt such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, a soap such as an alkanolamide salt or an amino acid salt, and an amino acid-based interface such as sodium cocoyl glutamate and sodium cocoyl methyl taurate. Activator, ether sulfate ester salt such as sodium laureth sulfate, ether carboxylate salt such as sodium lauryl ether acetate, sulfosuccinate ester salt such as sodium alkyssulfosuccinate, coconut oil fatty acid monoethanolamide, coconut oil fatty acid diethanolamide, etc. Fatty acid alkanolamides, sodium lauryl phosphate, monoalkyl phosphate ester salts such as sodium polyoxyethylene lauryl ether phosphate, coconut oil fatty acid amide propyldimethylaminoacetic acid betaine, lauryldimethylaminoacetic acid betaine, 2-alkyl-N-carboxyl Betaine-type amphoteric surfactants such as methyl-N-hydroxyethylimidazolinium betaine, lauryl hydroxysulfobetaine and lauroylamidoethyl hydroxyethyl carboxymethyl betaine hydroxypropyl sodium phosphate, amino acid-type amphoteric surfactants such as sodium laurylaminopropionate Agents and the like.

<Keratin soft ingredient>
Examples of the keratin softening component include lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, citric acid, fruit acid, phytic acid, urea and sulfur. Of these, lactic acid, sodium lactate, glycolic acid, salicylic acid, phytic acid, and citric acid are preferable.

<Cell activation component>
Examples of the cell activating component include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid: vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pyrroloquinoline quinone pantothenate; gluconic acid, phytic acid, glycol Α-hydroxy acids such as acid and lactic acid; tannin, persimmon tannin, flavonoid, saponin, allantoin, Photosensitizer No. 301, panthenol, components derived from plants (eg, soybean sprouts, bilberry leaves, etc.) and the like.

<Anti-aging ingredient>
Examples of the antiaging component include hydrolyzed soybean protein, retinoid (retinol, retinoic acid, retinal, etc.), pangamic acid, ursolic acid, turmeric extract, sphingosine derivative, silicon, silicic acid, N-methyl-L-serine, mevalonolactone. , Peptides (caproyl tetrapeptide-3, oligopeptide-24, etc.) and the like. Of these, hydrolyzed soybean protein, retinol, retinol acetate, retinol palmitate, caproyl tetrapeptide-3 and oligopeptide-24 are preferable.

<Anti-glycation component>
Examples of the anti-saccharification component include plant extracts such as Budreja axillaris leaf extract, plum fruit extract, and edelweiss extract, evening primrose oil, Amla fruit, fruit juice or their extracts, L-arginine, L-lysine, and hydrolysis. Examples include casein, hydrolyzable tannin, carnosine and the like.

<Scalp hair care ingredients>
Examples of the scalp hair care component include minoxidil, finasteride, carpronium chloride, pyridine N-oxide, nicotinic acid derivative (nicotinamide, benzyl nicotinate, tocopherol nicotinate, etc.), γ-oryzanol, capsicum tincture, cepharanthin, vitamin. B2s, Vitamin B6s, Vitamin B12s, Pantothenic acid, Tocopherol acetate, Tocopherol, Panthenol, Biotin, Hydrolyzed soy protein, Soybean extract, Yokuinin, Ginkgo biloba extract, Carrot extract, Assemblage extract, Aloe extract, etc. The natural extract, the mallow extract, the caffeine, the chamomile extract, the seaweed extract, the fucoidan, the gentian extract, the neem extract, the citrus ginseng tincture, the cashew tincture, the arnica tincture, the female hormones (such as estradiol) and the like can be mentioned.

<pH>
The pH of the scalp antiperspirant composition of the present invention is not particularly limited as long as the effects of the present invention can be exhibited, but is, for example, pH 3 or more, preferably pH 3.5 or more, and more preferably pH 4 or more. , PH 9 or less, preferably pH 8 or less, and more preferably pH 7.5 or less.

<Formulation>
The antiperspirant composition for scalp of the present invention is not particularly limited as long as it is a known form, and for example, a liquid agent, a suspending agent, an emulsion, a cream agent, an ointment agent, a gel agent, a liniment agent, a lotion agent, an aerosol agent. It can be formulated by a known method depending on the form of a sheet agent, a mist agent or the like obtained by impregnating a sheet such as a powder agent or a non-woven fabric with the antiperspirant composition for scalp. Of these, liquids, suspending agents, emulsions, creams, emulsions, ointments, gels, lotions, sheets, aerosols and mists are preferable, and liquids, suspending agents, emulsions, gels. , Lotion agents, sheet agents, aerosol agents and mist agents are more preferable, and liquid agents, suspending agents, lotion agents, sheet agents, aerosol agents and mist agents are even more preferable.

<Aerosol agent>
The aerosol is prepared by filling the scalp antiperspirant composition and the propellant in an aerosol-type spray container. Examples of the propellant used for the aerosol agent include CFCs such as CFC 11, CFC 12, CFC 21, CFC 113, CFC 114, CFC 134a, liquefied petroleum gas (LPG) such as propane, isobutane, and normal butane, and dimethicone. Liquefied gas such as Lether (DME) may be used. In addition to these, carbon dioxide gas, nitrogen gas, oxygen gas and the like may be used.

The ratio of the scalp antiperspirant composition to the propellant (weight ratio of scalp antiperspirant composition/propellant) is not particularly limited, but is usually 1:9 to 9:1 and 2:8 to 8:. 2 is preferred.

<Sheet agent>
The sheet agent is obtained by impregnating a sheet base material with the antiperspirant composition for scalp of the present invention. The sheet base material is not particularly limited as long as it can impregnate and carry the scalp antiperspirant composition, and woven fabric, non-woven fabric, and the like can be arbitrarily used. The fibers constituting the woven or non-woven fabric are not particularly limited, and can be selected from, for example, synthetic fibers, natural fibers, or fibers obtained by mixing and combining these. Specific examples thereof include fiber materials such as rayon fiber, cotton, pulp, cellulose, tencel, lyocell, chitin, chitosan, collagen, and alginic acid, but are not limited thereto. Further, it may contain any thermoplastic binder, for example, polyolefin type such as polyethylene and polypropylene; polyester type such as polyethylene terephthalate, polytrimethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate and polybutylene naphthalate; nylon and the like. Polyamide-based; polyacrylonitrile-based thermoplastic binders composed of various resins, but are not limited thereto. Further, the thermoplastic binder contained in the nonwoven fabric may contain one kind alone from the above, or may contain two or more kinds in arbitrary combination.
The basis weight of the sheet base material is not particularly limited, and is, for example, 10 to 100 g/m ² , preferably 20 to 80 g/m ² , more preferably 30 to 70 g/m ² , and further preferably 30 to 60 g/m ² . ^{Is 2} .
Further, the sheet base material does not have such a three-dimensional pattern, even if the sheet base material has a three-dimensional pattern in which at least one surface of the front surface and the back surface is irregularly and regularly expressed in any shape. It may be a non-sheet base material. The concavo-convex shape can be processed by any method such as mesh processing, embossing, dot processing, or a combination of these processing methods. A method including mesh processing (for example, a method of performing only mesh processing, a mesh A method combining processing and embossing, a method combining mesh processing and dot processing, etc.) are preferable.
The amount of the scalp antiperspirant composition with which the sheet base material is impregnated is not particularly limited, and it can be usually impregnated in the range of 0.5 to 20 times the weight of the sheet base material, preferably 1 time. 10 times.
The scalp sheet agent impregnated with the anti-perspirant composition for scalp of the present invention is, by wiping the head with the scalp sheet agent, suppresses the generation of sweat from the scalp, and skin resident bacteria of the scalp. In addition to being able to suppress the odor of the scalp while suppressing the effect on the above, it is preferable in that the sweat and the sebum can be wiped off and the refreshment can be easily performed. Among them, the scalp sheet agent impregnated with the anti-perspirant composition for scalp of the present invention is, for example, when wiping around the forehead part where sweat is easily wiped or around the occipital region where odor is likely to be muffled, the head of short hair such as cut hair or short hair. It is more preferably used when the entire part is wiped.

<Container>
The antiperspirant composition for scalp of the present invention can be used by containing it in a container having a shape and a material appropriately selected according to the purpose of use and application. Specific examples of the container include spray type, bottle type, tube type, jar type, spoid type, dispenser type, stick type, pouch bags, and cheer packs. The anti-perspirant composition for scalp of the present invention has a sponge head, a drip-type head, a pen-type head, a roll-on type head, a spatula-shaped head, and a brush for the head portion of each container from the viewpoint of easy application to the scalp. It can be used by changing it to a circular head or a sword-shaped head. Examples of the material of the container include polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, metal (aluminum, etc.), and the like. Further, these materials may be subjected to various coating treatments in consideration of strength, flexibility, weather resistance, stability of components, etc., or these materials may be combined, for example, by mixing, or laminated. Can be used as a container material. Examples of the coating material include epoxy resin and polyamide-imide. Among them, polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ethylene vinyl alcohol resin, and metal (aluminum, etc.) are preferably used.

As the container for the sheet material, it is preferable to provide the container by packaging it in a highly hermetic container. The sheet material may be individually packaged as a one-time use type, or may be packaged together with the wiping sheet material for the number of times of use so that it can be used multiple times. In the case of packaging as a multi-use type, it is preferable that the container has a structure in which the lid can be opened and closed each time it is used and the opening can be closed when not in use. Here, the lid member that opens and closes the opening may be a lid member integrally formed with the container, a lid member connected to the container, or removable from the container. The lid member may be in any state. The lid member that can be detached from the container may be, for example, a seal-like member provided with an adhesive layer, the opening of which can be sealed with the adhesive layer each time it is used. Further, when the seal-like member is used, the adhesive layer does not necessarily have to be present on the surface of the lid member side, and may be present on the surface of the container side (for example, around the opening). As the material of the container and the lid member, any material well known in the art and having excellent airtightness can be used. For example, a polyolefin resin such as polyethylene or polypropylene; a metal such as aluminum; a laminate of aluminum foil. Examples of the laminated film include, but are not limited to: From the viewpoint of being easy to carry and handle when going out, it is preferably a bag-shaped container composed of a laminated film laminated with aluminum foil, and the opening is provided by a seal-shaped lid member. It is preferably packaged in a container that can be opened and closed.

<Use>
Specific examples of the use as a composition for quasi-drugs or cosmetics include, for example, lotion, emulsion, gel, cream, beauty essence, cosmetics with sunscreen function, mist, spray, and wipe sheet. Such as basic cosmetics for the scalp; and cleansing cosmetics such as dry shampoos, shampoos, rinses and treatments.

<Viscosity>
The viscosity (25° C.) of the scalp antiperspirant composition of the present invention is not particularly limited as long as the effects of the present invention can be exhibited, but for example, a liquid agent, a suspending agent, a lotion agent, an aerosol agent, a mist agent, and a sheet. In the case of the agent, the range of 0.01 to 50,000 mPa·s is preferable. Furthermore, the range of 0.1-5000 mPa*s is more preferable, and the range of 1-1000 mPa*s is more preferable. In the case of emulsion, gel, and cream, the range of 10 to 1,000,000 mPa·s is preferable. Furthermore, the range of 1000-500000 mPa*s is further preferable, and the range of 10000-100000 mPa*s is more preferable. The viscosity (25° C.: mPa·s) was measured by a single cylindrical rotary viscometer (Brookfield viscometer) according to the viscosity measurement method described in the general test method of the 17th revised Japanese Pharmacopoeia. It is the measured viscosity.

<Production method>
The method for producing the antiperspirant composition for scalp of the present invention is not particularly limited, and the components (A) to (D) and other components are dissolved, mixed or dispersed by a conventional method depending on the dosage form and form. It can be manufactured.

<Use>
INDUSTRIAL APPLICABILITY The present invention is a scalp antiperspirant composition useful for the scalp, and can be used for controlling skin-resident bacteria of the scalp or for suppressing odor of the scalp. The agent used for controlling the skin-resident bacteria of the scalp can suppress the imbalance of the skin-resident bacteria of the scalp by suppressing the bactericidal effect on Staphylococcus captis, which is the skin-resident bacteria of the scalp. It is beneficial in terms. Specifically, a scalp skin indigenous bacteria control agent that uses a combination of a specific bactericidal component and an antiperspirant component is a component having a relatively high bactericidal effect against Staphylococcus captis among the bactericidal component or the antiperspirant component. Since the bactericidal effect exceeding the bactericidal effect is not produced, the bactericidal effect of the scalp on the skin indigenous bacteria can be suppressed, which is advantageous in that the balance of the skin resident bacteria on the scalp can be suppressed. The bactericidal effect can be confirmed by a test by a diffusion method (perforated flat plate method) described later. In addition, a combination of a specific bactericidal component and an antiperspirant component, which is used to suppress the odor of the scalp, can suppress the odor of the scalp by suppressing the metabolism of Staphylococcus captis, which is a skin-resident bacterium of the scalp. It is beneficial in terms. In addition, a combination of a specific bactericidal component and an antiperspirant component, which is used to suppress the odor of the scalp, can suppress the odor for a long time, and since the suppression effect is persistent, it is possible to spend without worrying about the odor. Especially useful.

Further, when the balance of skin-resident bacteria of the scalp is disturbed, the health condition of the scalp is deteriorated, hair loss and the like are promoted, and normal growth of hair may be inhibited. By suppressing the bactericidal effect against Staphylococcus captis, which is a skin-resident bacterium, it is possible to prevent the balance of the skin-resident bacteria on the scalp from being disrupted. The scalp antiperspirant composition of the present invention may be contained in a hair cosmetic composition for use in hair care, promotion of hair growth, prevention of hair loss, improvement of thin hair, improvement of thin hair, improvement of soft hair, prevention or improvement of dandruff.

Further, when the scalp sweats, stuffiness occurs due to the hair or the hat, so that it is easy to cause itching and discomfort in addition to the above-mentioned effects on the balance of skin-resident bacteria and the generation of odor. INDUSTRIAL APPLICABILITY The present invention is a scalp antiperspirant composition useful for the scalp, and therefore, for example, in addition to use during periods when the temperature and humidity are high, when wearing a hat (especially when wearing for a long time), before styling in the morning, It is suitable for use in situations where people approach people, before and after exercise, when they want to change their mood, and so on.

<Method>
The present invention uses at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and an antiperspirant component, and skin-resident bacteria of the scalp. It includes a method of controlling the. Further, the present invention uses at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and an antiperspirant component to reduce the odor of the scalp. The method of suppressing is included. Further, the present invention uses at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and an antiperspirant component for the scalp. It also includes a method of suppressing the composition from dripping.

Hereinafter, the present invention will be described in more detail based on examples, but the present invention is not limited to these examples.

[Test Example 1. Sterilization effect evaluation test]
In order to evaluate the bactericidal effect of the present invention on the skin resident bacteria of the scalp, Staphylococcus captis (Staphylococcus captis) as the skin resident bacteria of the scalp, isopropylmethylphenol, benzalkonium chloride and hinokitiol as bactericidal components, and antiperspirant Chlorhydroxyaluminum and zinc paraphenolsulfonate were prepared as components, and a test was conducted by the following diffusion method (perforated plate method).

Staphylococcus captis bacterial solution was spread on MH agar medium (Mueller-Hinton agar medium, petri dish diameter 9 cm) inoculated with about 10 ⁶ CFU/mL, and sterilized perforation cutter (TOYOBO, biopsy punch 8 mm, stainless steel). ), a hole having a diameter of 8 mm was opened in the agar medium, and each test sample shown in Table 1 was injected into the hole (about 0.1 g), and cultured at 33° C. for 24 hours. After culturing, the diameter (mm) of the inhibition circle was measured, and the average value (n=3) was calculated. The results are shown in Table 1.

From the test results shown in Table 1, as in Example 1-1, when benzalkonium chloride and zinc paraphenolsulfonate are used in combination, no additive bactericidal effect on skin-resident bacteria of the scalp occurs. Was confirmed. Specifically, as compared with the size of the inhibition circle in Comparative Example 1-4 containing benzalkonium chloride as a bactericidal component alone, benzalkonium chloride as a bactericidal component and paraphenolsulfone as an antiperspirant component were compared. It was confirmed that the size of the inhibition circle in Example 1-1 in which zinc acid was used in combination was not enlarged, and no additive bactericidal effect was produced.

Further, from the test results shown in Table 1, if isopropylmethylphenol and chlorohydroxyaluminum are used in combination as in Example 1-2, no additive bactericidal effect on the skin-resident bacteria of the scalp may be produced. confirmed. Specifically, as compared with the size of the inhibition circle in Comparative Example 1-5 containing isopropylmethylphenol alone which is a bactericidal component, isopropylmethylphenol which is a bactericidal component and chlorhydroxyaluminum which is an antiperspirant component are compared with each other. It was confirmed that the size of the inhibition circle of Example 1-2 used in combination was not enlarged, and no additive bactericidal effect was produced.

In addition, from the test results shown in Table 1, when benzalkonium chloride and chlorohydroxyaluminum are used in combination as in Example 1-3, no additive bactericidal effect against skin-resident bacteria of the scalp does not occur. Was confirmed. Specifically, compared with the size of the inhibition circle in Comparative Example 1-4 containing benzalkonium chloride as a bactericidal component alone, benzalkonium chloride as a bactericidal component and chlorhydroxyaluminum as an antiperspirant component are compared. It was confirmed that the size of the inhibition circle in Example 1-3 in which both and were used in combination was not enlarged, and no additive bactericidal effect was produced.

In addition, from the test results shown in Table 1, when isopropylmethylphenol and zinc paraphenolsulfonate are used in combination as in Example 1-4, no additive bactericidal effect against skin-resident bacteria of the scalp does not occur. It was confirmed. Specifically, in comparison with the size of the inhibition circle in Comparative Example 1-2, which contains isopropylmethylphenol and zinc paraphenolsulfonate alone, zinc paraphenolsulfonate, which is a component in which the inhibition circle is formed, is included. The size of the inhibition circle of Example 1-4 in which isopropylmethylphenol which is a bactericidal component and paraphenolsulfonic acid which is an antiperspirant component are used in combination has not expanded, and an additive bactericidal effect does not occur. Was confirmed.

As described above, according to Examples 1-1 to 1-4, since an additive bactericidal effect does not occur against Staphylococcus captis, which is a skin resident bacteria of the scalp, the skin resident of the scalp is not present. It has the effect that the ecological balance of the fungus is not easily destroyed and that it is easily retained.

On the other hand, from the test results shown in Table 1, it was confirmed that, as in Comparative Example 1-7, when hinokitiol and zinc paraphenolsulfonate were used in combination, an additive bactericidal effect was produced against skin-resident bacteria of the scalp. Was done. Specifically, compared to the size of the inhibition circle in Comparative Example 1-3 containing hinokitiol as a bactericidal component alone, hinokitiol as a bactericidal component and zinc paraphenolsulfonate as an antiperspirant component were used in combination. The size of the inhibition circle in Comparative Example 1-7 was enlarged, and it was confirmed that an additive bactericidal effect was produced.

As described above, Comparative Example 1-7 causes an additive bactericidal effect on Staphylococcus captis, which is a skin resident bacteria of the scalp, and thus disrupts the ecological balance of skin resident bacteria on the scalp. It can be said that it is easy and difficult to hold.

From the above, when using a bactericidal component and an antiperspirant component together, depending on the type of each component, an additive bactericidal effect occurs, while it is confirmed that the ecological balance of skin-resident bacteria in the scalp is destroyed. According to the present invention, since no additive bactericidal effect is produced, it has been confirmed that the ecological balance of skin-resident bacteria in the scalp is not easily disturbed, and that it is easy to maintain this.

[Test Example 2. Evaluation of inhibition of bacterial metabolism of sebum]
It is known that odor-causing substances are generated by triglyceride in sebum being metabolized by skin-resident bacteria. Therefore, in order to evaluate the bacterial metabolism inhibitory effect of the present invention on the skin resident bacteria of the scalp, triolein as the triglyceride which is the main component of sebum, Staphylococcus captis as the skin resident bacteria of the scalp, and isopropylmethyl as the bactericidal component. Phenol, benzalkonium chloride and hinokitiol, chlorohydroxyaluminum and zinc paraphenolsulfonate as antiperspirant components were prepared and the following tests were conducted.

To tryptic soy agar medium (dishes diameter 9 cm), triolein 0.005 cc/cm ² and Staphylococcus captis were adjusted to a bacterial count of 6.5×10 ⁵ /cm ^2, and the following bacterial solution was applied. Each test sample shown in Table 2 was coated with 0.3 cc per petri dish, cultivated at 35° C. for 3 days, extracted with ether, and extracted with gas chromatograph (GC-MS) analysis under the following measurement conditions. The oleic acid in the sample was quantified.
Since the amount of oleic acid that causes odor of the scalp increases due to the decomposition of triolein, the scalp odor is suppressed as the amount of oleic acid decreases.

<GC-MS measurement conditions>
・Model: Agilent Technologies Gas Chromatograph-Mass Spectrometer (GC-MS)
GC: 7890B
MS: 5977A
Column: HP Science Inc. HPINNOWAX 30 m, 0.25 mm I.D. D. , 0.25 μm
Carrier gas: He
<GC conditions>
Temperature: 80°C ⇒ temperature increase (20°C/min) ⇒ 260°C (6 minutes)
Flow rate: 1 mL/min
Injection volume: 1 μL
Inlet port: 260°C
Split ratio 10:1
<MS conditions>
Ionization method: Electron ionization method (EI)

As a blank, oleic acid was quantified by performing the same steps as above except that the bacterial solution and each test sample were not applied. Further, as a control, the same steps as described above were performed except that each test sample was not applied to quantify oleic acid.

The value obtained by subtracting the blank quantitative value from each quantitative value of each Example, each Comparative Example, and the control was taken as the true oleic acid amount of each Example, each Comparative Example, and the control. Taking the true oleic acid amount of the control as 100, the oleic acid amount of each Example and each Comparative Example was determined, and the result is shown in FIG.

From the test results shown in FIG. 1, it was confirmed that the combined use of benzalkonium chloride and zinc paraphenolsulfonate of Example 2-1 can suppress the amount of triolein decomposed by the skin-resident bacteria of the scalp. .. Specifically, since the amount of oleic acid in Example 2-1 in which benzalkonium chloride and zinc paraphenolsulfonate were used in combination was remarkably reduced as compared with the amount of oleic acid in the control, the skin of the scalp It was confirmed that the amount of triolein degraded by indigenous bacteria could be suppressed.

From the results of the bacterial metabolism inhibition evaluation test of Example 2-1 and the bactericidal effect evaluation test of Example 1-1, according to the combined use of benzalkonium chloride and zinc paraphenolsulfonate, an antiperspirant component was obtained. While it can suppress the generation of sweat by the action, it does not cause an additive bactericidal effect, so it does not disturb the ecological balance of skin resident bacteria on the scalp and the amount of triolein decomposed by skin resident bacteria on the scalp. It was confirmed that the odor of the scalp can be suppressed because it can be suppressed, and that it is extremely useful as an antiperspirant composition for the scalp.

On the other hand, from the test results shown in FIG. 1, according to the combined use of the hinokitiol of Comparative Example 2-6 and chlorohydroxyaluminum, and the combined use of the hinokitiol of Comparative Example 2-7 and zinc paraphenolsulfonate, skin resident of the scalp It was confirmed that the amount of decomposition of triolein by the fungus could not be suppressed. Specifically, as compared with the amount of oleic acid in the control, Comparative Example 2-6 in which hinokitiol and chlorohydroxyaluminum were used in combination, and oleic acid in Comparative Example 2-7 in which hinokitiol and zinc paraphenolsulfonate were used in combination. The amount did not decrease, and it was confirmed that the amount of triolein decomposed by the skin resident bacteria of the scalp could not be suppressed.

From the results of the bacterial metabolism inhibition evaluation test of Comparative Example 2-6 in FIG. 1 and the bactericidal effect evaluation test of Comparative Example 1-6 in Table 1, according to the combined use of hinokitiol and chlorhydroxyaluminum, additive It was confirmed that the odor of the scalp could not be suppressed because the amount of triolein decomposed by the bacteria indigenous to the scalp could not be suppressed, although the bactericidal effect was not produced.

From the results of the bacterial metabolism inhibition evaluation test of Comparative Example 2-7 of FIG. 1 and the bactericidal effect evaluation test of Comparative Example 1-7 of Table 1, according to the combined use of hinokitiol and zinc paraphenolsulfonate, An additional bactericidal effect is generated, it is easy to disturb the ecological balance of skin resident bacteria on the scalp, and it is not possible to suppress the odor of the scalp because the amount of triolein decomposed by the skin resident bacteria of the scalp cannot be suppressed. Was confirmed.

From the above, when using a bactericidal component and an antiperspirant component together, depending on the type of each component, an additive bactericidal effect occurs, the ecological balance of skin-resident bacteria in the scalp is upset, and the odor of the scalp It was confirmed that it could not be suppressed. On the other hand, according to the combined use of a specific bactericidal component and an antiperspirant component as in the present invention, while suppressing the generation of sweat, because it does not produce an additive bactericidal effect, skin resident bacteria of the scalp It has been confirmed that the balance of the ecosystem is difficult to be destroyed and is easily maintained, and the amount of triolein decomposed by skin-resident bacteria on the scalp can be suppressed, so that the odor of the scalp can be suppressed.

[Test Example 3. Evaluation of inhibition of bacterial metabolism of sebum]
The combined use of different types of bactericidal components is important from the viewpoint of exhibiting a bactericidal effect suitable for various skin conditions such as the amount of sebum present in the skin. Therefore, in order to evaluate the bacterial metabolism inhibitory effect in the present invention in the case of containing a plurality of bactericidal components, as shown in Table 3, a test sample containing a bactericidal component and an antiperspirant component, and further to the test sample, Each test sample prepared by mixing different types of bactericidal components was prepared, and the following tests were conducted.

To tryptoso agar medium (dishes diameter 9 cm), 0.005 cc/cm ² of triolein and Staphylococcus captis were applied to a bacterial solution adjusted to a number of 6.5×10 ⁵ /cm ^2, and then Table 3 Each test sample shown in 3 was coated with 0.3 cc per petri dish, cultured at 35° C. for 3 days, extracted with ether, and oleic acid in each extract was quantified using gas chromatograph (GC-MS) analysis. .. The measurement conditions of the gas chromatograph (GC-MS) are the same as in Test Example 2.

With the quantified amount of oleic acid of Comparative Example 3-1 being 100 (reference), the amounts of oleic acid of Example 3-1 and Example 3-2 were determined, and the results are shown in FIG.

From the test results shown in FIG. 2, according to the combination of benzalkonium chloride, isopropylmethylphenol and zinc paraphenolsulfonate of Example 3-2, benzalkonium chloride and zinc paraphenolsulfonate of Example 3-1 were used. It was confirmed that the amount of triolein decomposed by the skin resident bacteria of the scalp could be suppressed to the same extent as that of the combination. Specifically, for example, since there is a bactericidal component such as hinokitiol that cannot suppress the bacterial metabolism and promotes the bacterial metabolism (see Comparative Example 2-3 of Test Example 2), depending on the type of the bactericidal component to be combined. Where bactericidal metabolism suppressing effect may be impaired, as in Example 3-2, benzalkonium chloride as a bactericidal component, zinc paraphenolsulfonate as an antiperspirant component, and isopropylmethyl as a bactericidal component are further included. It was confirmed that those containing phenol do not impair the bacterial metabolism suppressing effect.

As described above, according to the combination of benzalkonium chloride, isopropylmethylphenol, and zinc paraphenolsulfonate of Example 3-2, the amount of triolein decomposed by the skin-resident bacteria in the scalp can be suppressed, and thus the odor of the scalp can be reduced. It was confirmed that it can be suppressed, and it was confirmed that the use of different types of bactericidal components can exert a bactericidal effect suitable for various skin conditions such as the amount of sebum present in the skin.

[Test Example 4. Drug Product Usability Evaluation Test]
The following tests were conducted to evaluate the usability of the present invention.
Commercially available artificial leather (Idemitsu Techno Fine Co., Suprare PBZ13001) 2 cm×15 cm coated with 15 μL of jojoba oil (Nikko Chemicals Co., Ltd., NIKKOL Jojoba Oil S) was placed almost vertically, and each formulation example shown in Table 4 was obtained. 5 μL was dropped, and the dripping length (cm) after 15 seconds was measured. The results are shown in Table 4. In addition, the compounding quantity in the following Examples and Comparative Examples is w/w %.

From the test results shown in Table 4, according to the formulation containing benzalkonium chloride and chlorohydroxyaluminum or zinc paraphenolsulfonate as in Examples 4-1 and 4-2, the drooping condition was unexpectedly high. It was confirmed that the above can be improved. Specifically, the sagging length in Example 4-1 in which benzalkonium chloride and chlorohydroxyaluminum are used in combination and in Example 4-2 in which benzalkonium chloride and zinc paraphenolsulfonate are used in combination are It was confirmed that there was no discomfort and the usability on the scalp was good because the amount was smaller than that of Comparative Examples 4-1, 4-2 and 4-3, which were single substances.

In addition, from the test results shown in Table 4, according to the formulations containing isopropylmethylphenol and chlorohydroxyaluminum or zinc paraphenolsulfonate as in Examples 4-3 and 4-4, it was unexpectedly dripping. It was confirmed that the condition could be improved. Specifically, the sagging length in Example 4-3 in which isopropylmethylphenol and chlorohydroxyaluminum are used in combination and in Example 4-4 in which isopropylmethylphenol and zinc paraphenolsulfonate are used in combination It was confirmed that there was no discomfort and the usability on the scalp was good because the amount was decreased as compared with Comparative Examples 4-1, 4-2 and 4-4.

Furthermore, from the test results shown in Table 4, as in Examples 4-5 and 4-6, according to the formulation containing glycyrrhetinic acid and chlorohydroxyaluminum or zinc paraphenolsulfonate, the drooping condition was unexpectedly high. It was confirmed that the above can be improved. Specifically, the sagging lengths in Examples 4-5 in which glycyrrhetinic acid and chlorohydroxyaluminum are used in combination and in Examples 4-6 in which glycyrrhetinic acid and zinc paraphenolsulfonate are used in combination are the respective components alone. It was confirmed that there was no discomfort and the usability on the scalp was good because the amount was smaller than those in Example 4-1, Comparative Example 4-2 and Comparative Example 4-5.

[Test Example 5. Formulation usability and usability evaluation test]
In order to evaluate the usability and feeling of use of the present invention, for each formulation example shown in Table 5, the same usability evaluation test (evaluation of the drooping length of the formulation) and the following usability evaluation were performed as in Test Example 4 above. The test was conducted.
To evaluate the feeling of use, each formulation example was filled in a general trigger-type spray bottle (spray amount 0.3 mL to 0.5 mL) that can be sprayed in the form of mist, and 5 specialized panelists took the scalp from a distance of 5 cm from the scalp. Each one push was sprayed onto the skin, and the three items of "stickiness of scalp", "clean feeling of scalp", and "quick dry feeling" were evaluated on a scale of 1 to 10. The higher each value is, the higher the evaluation is. The average score of the evaluation results of 5 panelists was calculated and evaluated according to the following criteria. The results are shown in Table 5.
The compounding amount in the following examples and comparative examples is w/w%.
[Evaluation criteria]
◎: 7 points or more ○: 5 points or more and less than 7 points △: 3.5 points or more and less than 5 points ×: Less than 3.5 points

From the test results shown in Table 5, as in Example 5-1, according to the formulation containing benzalkonium chloride and chlorohydroxyaluminum, corn starch as a powder, and 1-menthol as a cooling component, It was confirmed that not only the dripping condition can be improved unexpectedly, but also a particularly excellent feeling of use can be obtained. Further, as in Example 5-2, according to the formulation containing zinc paraphenolsulfonate, isopropylmethylphenol, talc which is a powder, and l-menthol which is a cooling component, the drooping condition is unexpectedly high. It was confirmed that not only can it be improved, but also an excellent usability can be obtained. On the other hand, Comparative Example 5-1 which differs from Example 5-1 only in not containing chlorohydroxyaluminum may be inferior to Example 5-1 in both the sagging length and the feeling of use. confirmed.

As described above, according to the present invention in which a specific bactericidal component and an antiperspirant component are used in combination, it is possible to suppress the occurrence of sweat, and it is difficult to disturb the ecological balance of skin-resident bacteria in the scalp, and the odor of the scalp can be suppressed. .. That is, in addition to the sweat odor of the scalp, comprehensively suppress the odor of the scalp, such as the oxidative odor caused by the mixture of sweat and sebum, and the fatty acid odor discharged by the decomposition of sebum or the metabolism by the skin-resident bacteria. Can be done.
In addition to this, it was further confirmed that a remarkable effect that the usability on the scalp was good was exhibited.
In addition, in the present invention in which a specific bactericidal component and an antiperspirant component are used in combination, it has been confirmed that when a powder or a refreshing component is further mixed, a remarkable effect that a feeling of use is good is exhibited.

Hereinafter, formulation examples of the antiperspirant composition for scalp of the present invention will be shown. In addition, the compounding quantity in the following formulation examples is w/w%.

(Preparation example 1) (Liquid formulation) (Mist type)
Isopropylmethylphenol 0.1%
Chlorhydroxyaluminum 10%
70% ethanol
Hydroxyethyl cellulose 0.2%
l-menthol 0.3%
Green tea extract 0.1%
Fragrance (soap type) Appropriate amount of water Remaining amount

(Formulation example 2) (Liquid formulation) (Roll-on type)
Benzalkonium chloride 0.1%
Zinc paraphenol sulfonate 3%
50% ethanol
Hydroxypropyl methylcellulose 0.2%
l-menthol 0.2%
l-menthyl glyceryl ether 0.1%
Hamamelis extract 0.1%
Neubara extract 0.1%
Starch aluminum octenyl succinate 5%
Fragrance (sweet floral type) Appropriate amount of water Remaining amount

(Pharmaceutical formulation example 3) (Liquid formulation) (Drop type)
Glycyrrhetinic acid 0.1%
Chlorhydroxyaluminum 15%
50% ethanol
Xanthan gum 0.2%
Persimmon tannin 0.1%
Green tea extract 0.1%
Assembly extract 0.1%
Paraben 0.2%
Water remaining

(Formulation prescription example 4) (liquid) (brush type)
Benzalkonium chloride 0.05%
Isopropylmethylphenol 0.1%
Zinc paraphenol sulfonate 1%
Ethanol 20%
Carrageenan 0.3%
1,3-butylene glycol 10%
Cationized cellulose 1%
Polyoxyethylene hydrogenated castor oil 0.5%
Tocopherol acetate 0.1%
Mugwort extract 0.1%
Water remaining

(Formulation example 5) (Emulsion) (Bottle type)
Triclosan 0.1%
Benzethonium chloride 0.05%
Aluminum chloride 5%
Diethyl sebacate 2%
Liquid paraffin 2%
Sorbitan monostearate 0.5%
Polysorbate 60 0.7%
Ethanol 10%
Carboxy vinyl polymer 0.2%
Phenoxyethanol 0.3%
Nylon powder 1%
Aloe extract 0.1%
Triethanolamine Appropriate amount of water Remaining amount

(Formulation Example 6) (Aerosol, (liquid: propellant = 1:1))
Benzalkonium chloride 0.03%
Isopropylmethylphenol 0.03%
Chlorhydroxyaluminum 10%
Ethanol 30%
l-menthol 0.1%
1-menthyl glyceryl ether 0.05%
Hamamelis extract 0.1%
Neubara extract 0.1%
Talc 5%
Corn starch 3%
Fragrance (fresh citrus system) Appropriate amount of water DME 50% remaining amount

(Formulation Formulation Example 7) (Aerosol, (Liquid: Propellant = 6:4))
Benzethonium chloride 0.03%
Trichlorocarbanilide 0.03%
Zinc paraphenol sulfonate 2%
40% ethanol
l-menthol 0.1%
1-menthyl glyceryl ether 0.05%
Hamamelis extract 0.1%
Chamomile extract 0.1%
Nylon powder 5%
Starch octenyl succinate aluminum 3%
Fragrance (citrus herb type) Appropriate amount of water LPG 40% remaining

(Formulation Example 8) (Dry shampoo) (aerosol, (liquid: propellant=6:4))
Isopropyl methylphenol 0.01%
Zinc paraphenol sulfonate 0.5%
Ethanol 30%
l-menthol 0.1%
1-menthyl glyceryl ether 0.05%
Hamamelis extract 0.1%
Chamomile extract 0.1%
Silica 5%
Mica 3%
Fragrance (Verbena system) Appropriate amount of water Remaining amount LPG 40%

(Formulation example 9) (Dry shampoo) (Mist type)
Benzalkonium chloride 0.01%
Isopropyl methylphenol 0.01%
Chlorhydroxyaluminum 1%
Ethanol 30%
l-menthol 0.3%
Cha extract 0.1%
Age extract 0.1%
Peony extract 0.1%
Talc 5%
Mica 3%
Fragrance (Geranium-based) Appropriate amount of water Remaining amount

(Formulation Example 10) (Wiping sheet)
(Sheet base material: cotton, rayon, polyester synthetic fiber)
Benzalkonium chloride 0.01%
Chlorhydroxyaluminum 5%
Ethanol 30%
Polyoxyethylene polyoxypropylene decyl tetradecyl ether
1%
l-menthol 0.2%
Peony extract 0.1%
Scutellaria extract 0.1%
Comfrey extract 0.1%
Fragrance (Citrus type) Appropriate amount of water Remaining amount

(Formulation Example 11) (Emulsion-impregnated wiping sheet)
(Sheet base material: cellulose)
Isopropyl methylphenol 0.05%
Zinc paraphenol sulfonate 3%
Sugar squalane 2%
Tri(capryl/capric acid) glyceryl 1%
Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol
0.3%
Methyl polysiloxane 0.5%
Xanthan gum 0.1%
Polyoxyethylene hydrogenated castor oil 0.5%
Lipophilic type glyceryl monostearate 0.3%
l-menthol 0.5%
Seaweed extract 0.1%
Artichoke extract 0.1%
Scutellaria extract 0.1%
Cha dry distillation liquid 0.1%
Assembly extract 0.01%
Carrot extract 0.01%
Cay skin extract 0.01%
Water remaining

(Formulation Example 12) (Liquid formulation) (Mist type)
Isopropyl methylphenol 0.05%
Zinc paraphenol sulfonate 3%
50% ethanol
Polyoxyethylene polyoxypropylene decyl tetradecyl ether
1%
(Eicosanedioic acid/tetradecanedioic acid) Decaglyceryl
0.5%
l-menthyl glyceryl ether 0.2%
l-menthol 0.5%
Lysozyme hydrochloride 0.1%
Cha dry distillation liquid 0.1%
Seaweed extract 0.01%
Yukinoshita extract 0.01%
Cha extract 0.01%
Hamamelis extract 0.01%
Peony extract 0.01%
Fragrance (botanical floral type) 0.05%
Water remaining

Claims (8)

Scalp antiperspirant containing (A) at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component Composition. The antiperspirant composition for scalp according to claim 1, wherein the phenolic bactericidal component is at least one selected from the group consisting of isopropylmethylphenol, triclosan, and trichlorocarbanilide. The quaternary ammonium salt is at least one selected from the group consisting of benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, and cetyltrimethylammonium bromide. The scalp antiperspirant composition described. Any of claims 1 to 3, wherein the component (B) is at least one selected from the group consisting of chlorohydroxyaluminum, aluminum chloride, aluminum zirconium complex salt, allantoin chlorohydroxyaluminum, and zinc paraphenolsulfonate. The antiperspirant composition for scalp according to 1). Further, the antiperspirant composition for scalp according to any one of claims 1 to 4, further comprising (C) powder. Further, the antiperspirant composition for scalp according to any one of claims 1 to 5, further comprising (D) a cooling component. The antiperspirant composition for scalp according to any one of claims 1 to 6, which is used for controlling skin-resident bacteria of the scalp. Scalp skin using (A) at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component A method of controlling indigenous bacteria.