JP6912772B2 - Hyaluronic acid production promoter and cosmetics containing it - Google Patents

Description

The present invention relates to a hyaluronic acid production promoter containing a levan composition and a cosmetic containing the hyaluronic acid production promoter.

Hyaluronic acid is widely present in animal connective tissues such as the vitreous of the eye, chicken combs, combs, skin, and joint fluid. The skin contains the largest amount of hyaluronic acid in the body, and plays an important role as an extracellular matrix. Hyaluronic acid in the skin is known to decrease with age, and is thought to contribute to skin aging phenomena such as rough skin, decreased elasticity and firmness of the skin, wrinkles, and tarmi. Skin hyaluronic acid is divided into dermal hyaluronic acid and epidermal hyaluronic acid, and dermal hyaluronic acid is involved in the degeneration of tissue structure and reduction of elasticity in the formation of wrinkles, and affects the formation of deep wrinkles, while Epidermal hyaluronic acid is known to be involved in the volume of the epidermal layer and the water environment, and to affect the moisturizing property of the skin, rough skin, and the formation of fine wrinkles. Against this background, many cosmetics containing a hyaluronic acid production promoter have been proposed for the purpose of preventing and improving skin aging (for example, Patent Documents 1 and 2).

Levan is a type of polysaccharide that is widely distributed in nature and exists as a stored polysaccharide in the leaves, stems or roots of grasses and liliaceae plants. Its structure is that D-fructose is dehydrated and polymerized on the fructose side of sucrose with a β- (2 → 6) bond, and the degree of polymerization is said to be 25 to 50 (Non-Patent Document 1). On the other hand, levan is known to be produced by an enzyme derived from a microorganism, and industrially, one produced by such a method is generally used. Levan-producing microorganisms include Rahnella aquatilis, Serratia levanicum, Bacillus subtilis, Erwinia herbicola, and Bacillus leban. , Bacteroides fragilis, Streptococcus mutans, Streptococcus salivarius, Lactobacillus reuteri, Lactobacillus reuteri Paenibacillus polymyxa, Acetobacter xylinum, Lactococcus lactis, Actinomyces naeslundii, etc. are known, and these are levan from sugar. To produce. However, levan thus obtained has a huge molecular weight and has a structure in which a straight chain consisting of β- (2 → 6) bonds of D-fructose is highly branched by β- (2 → 1) bonds. It has and its properties are very different from those derived from plants.

As for the use of levan for cosmetics, Patent Document 3 describes that levan produced by microorganisms is useful for moisturizing, cell proliferation, alleviating skin irritation and the like. Patent Document 4 describes that levan has an excellent whitening effect, and the effect has been confirmed by using levan derived from a microorganism in Examples. Thus, although the effect of levan on cosmetics is known to some extent, the effect of promoting hyaluronic acid production has not been known at all. Moreover, the characteristics of low-polymerization levan in cosmetic applications were not known.

In addition, levan has a problem in terms of solubility when used as a cosmetic product, and therefore, it cannot be said that it is excellent in terms of usability.

Japanese Patent No. 4224998 Japanese Patent No. 4589865 Japanese Unexamined Patent Publication No. 2003-277225 Japanese Unexamined Patent Publication No. 2006-052146

Basics of carbohydrate chemistry, p. Published by Kodansha in 134, 1993

In view of the above circumstances, an object of the present invention is a hyaluronic acid production promoter having an excellent hyaluronic acid acidity promoting action on the skin and having excellent solubility and usability, and the hyaluronic acid production. The purpose is to provide cosmetics containing accelerators.

As a result of diligent research to achieve the above object, the present inventors have found that the above problem can be solved by using levan. The present inventors have further studied based on such findings, and have completed the present invention.

That is, the present invention provides the following hyaluronic acid acidity accelerators and cosmetics.
Item 1.
A hyaluronic acid production promoter comprising a levan composition.
Item 2.
Item 2. The hyaluronic acid production promoter according to Item 1, wherein the levan composition contains 95% by mass or more of levan having an average degree of polymerization of 14 to 21 and a degree of polymerization of 5 to 60 in 100% by mass of total levan.
Item 3.
A cosmetic containing the hyaluronic acid production promoter according to Item 2.

The hyaluronic acid production promoter and cosmetics according to the present invention have an excellent hyaluronic acid acidity promoting action on the skin, and are also excellent in solubility and usability.

The hyaluronic acid production promoter of the present invention is characterized by containing a levan composition. In general, when the hyaluronic acid in the skin decreases due to aging or ultraviolet rays, the elasticity and firmness of the skin decrease, and the skin aging phenomenon such as wrinkles and tarmi is caused. Therefore, it is possible to promote the hyaluronic acid production in the skin. It is effective in preventing and improving aging. In addition, promotion of epidermal hyaluronic acid production leads to improvement of skin moisturizing property, rough skin, and fine wrinkles. Since the hyaluronic acid production-promoting agent of the present invention has an excellent hyaluronic acid production-promoting action, the above-mentioned effects can be expected. In order to promote the production of hyaluronic acid in the skin by using the hyaluronic acid production promoter of the present invention, it is necessary to introduce the hyaluronic acid production promoter of the present invention into the skin. Is not particularly limited, and can be applied to the skin or used by a cosmetic method such as intradermal injection. For application to the skin, the hyaluronic acid production promoter of the present invention may be dissolved or dispersed in a physiologically acceptable medium, or the hyaluronic acid production promoter of the present invention may be used in commonly used cosmetics or cosmetics. It may be used by blending it with an external preparation for skin.

The method for producing the levan composition used for the hyaluronic acid production promoter of the present invention is not particularly limited, and those produced by a known method can be used. For example, a method of culturing in a sucrose-containing medium using the above-mentioned microbial enzyme can be mentioned. Usually, levan obtained by such a method can be obtained as having a high degree of polymerization having an average degree of polymerization of about 500 to 1000. Examples of the method for obtaining levan having a low degree of polymerization include a method obtained by extracting from a plant and a method obtained by adjusting conditions such as substrate concentration using a microbial enzyme such as Bacillus subtilis.

The degree of polymerization of the levan composition used in the hyaluronic acid growth-promoting agent of the present invention is not particularly limited, and any degree of polymerization can be used, but the hyaluronic acid growth-promoting effect is more exhibited. Therefore, those having a low degree of polymerization are preferable in terms of permeability to the skin. Further, out of 100% by mass of the total levan composition, it is preferable that levan having an average degree of polymerization of 10 to 21 and a degree of polymerization of 5 to 60 is contained in an amount of 95% by mass or more. Further, it is more preferable that levan having an average degree of polymerization of 14 to 21 and a degree of polymerization of 5 to 60 is contained in an amount of 95% by mass or more. By having such a structure, it is possible to obtain a hyaluronic acid production promoter having an excellent usability and solubility, which is important in cosmetic applications, in addition to the hyaluronic acid growth promoting effect.

The average degree of polymerization and the degree of polymerization of the above-mentioned levan composition can be determined by measuring pullulan or the like as a standard substance using gel permeation chromatography (GPC).

The amount of the hyaluronic acid production promoter of the present invention to be added to the cosmetic or external preparation for skin is not particularly limited, but is preferably 0.01 to 30% by mass based on 100% by mass of the total amount of the cosmetic or external preparation for skin. More preferably, it is 0.05 to 10% by mass. Furthermore, synergistic effects can be exhibited by using in combination with known antioxidants, whitening agents, collagen production promoters, hyaluronic acid production promoters and the like.

The cosmetics containing the hyaluronic acid production promoter of the present invention include, if necessary, additional components to be added to water and ordinary cosmetics, such as oil-based bases, surfactants, alcohols, moisturizers, polymers. Thickening / gelling agent, antioxidant, preservative, bactericidal agent, chelating agent, pH adjuster / acid / alkali, ultraviolet absorber, whitening agent, solvent, keratin peeling / dissolving agent, antipruritic agent, anti-inflammatory agent, anti-inflammatory agent Sweat agents, refreshing agents, antihistamines, astringents, stimulants, hair growth agents / blood circulation promoters, reducing agents / oxidizing agents, polymer powders, hydroxy acids, vitamins and their derivatives, sugars and their derivatives, organic Acids, enzymes, nucleic acids, hormones, inorganic powders, fragrances, pigments and the like may be contained to the extent that the effects of the present invention are not impaired.

Oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, araquil alcohol, behenyl alcohol, jojoba alcohol, chimil alcohol, seraquil alcohol, bacil alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimerdiol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Higher grades such as palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eikosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long chain branched fatty acids, dimer acid, hydrogenated dimer acid, etc. Fatty acids and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium and sodium salts, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin , Α-Olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalane, vaseline, solid paraffin and other hydrocarbons; candelilla wax, carnauba wax, rice wax, wood wax, honey wax, montan wax , Ozokerite, Celesin, Paraffin wax, Microcrystalin wax, Petrolatum, Fishertroph wax, Polyethylene wax, Ethylene-propylene copolymer and other waxes; Palm oil, Palm oil, Palm kernel oil, Saflower oil, Olive oil, Himasi oil, Avocado Oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rose hip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat Vegetable oils and fats such as germ oil, flaxseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef fat, milk fat, Animal oils and fats such as horse fat, egg yolk oil, mink oil and turtle oil; animal waxes such as whale wax, lanolin and orange raffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption-purified lanolin, lanolin acetate, liquid acetate lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine , Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin and other sphingolin lipids, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof, phospholipids such as lysolecithin; hydrogenated soybean phospholipids, partially hydrogenated soybeans Phosphorlipid derivatives such as phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, Cholesteryl nonanoate, Cholesteryl stearate, Cholesteryl isostearate, Cholesteryl oleate, Di (cholesteryl / behenyl / octyldodecyl) N-lauroyl-L-glutamate, Di (cholesteryl / octyldodecyl) N-lauroyl-L-glutamate, N- Diacylsarcosine alkyl esters such as di-lauroyl-L-glutamate (phytosteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl / octyldodecyl), N-lauroyl sarcosin isopropyl, cholesteryl 12-hydroxystearate, macadamia nuts. Sterol esters such as oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, isostearate phytosteryl, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; -Fatty acid complexes such as cholesterol complex, phospholipid-phytosterol complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl pariminate, octyldodecyl palmitate, cetyl octanate, hexyldecyl octanate, Isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecil neopentanoate, ne Isotridecyl opentanate, isostearyl neopentate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinic acid, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl ercatate Himasi oil, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methyl isostearate Monoalcoholic carboxylic acid esters such as heptyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate; cetyl lactate, diiso malate Oxyate esters such as stearyl, hydrogenated monoisostearate castor oil, γ-ercalactone; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (caprylic acid / capric acid) glyceryl, tri (Caprylic acid / capric acid / myristic acid / stearic acid) Glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eikosanate behate, trimethylol propane trioctanoate, triisostearate Methylolpropane, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl , Ditrimethylolpropane triethylhexanoate, (isostearic acid / sebacic acid) ditrimethylolpropane, pentaerythricyl triethylhexanoate, (hydroxystearic acid / stearic acid / logonic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, nona Polyglyceryl isostearate-10, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (Hexyldecanoic acid / sebacic acid) Diglyceryl oligoester, glycol distearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopenate, 2,4-diethyl-1,5-pentanediol dineopenate, etc. Polyhydric alcohol fatty acid esters; alkyl ethers such as dicaprylyl ether; diisopropyl dimergylinolate, diisostearyl dimerserinolate, dimerserylinolate di (isostearyl / phytosteryl), dimergilinolic acid (phytosteryl /) Behenyl), Dimerglinolic Acid (Phytosteryl / Isostearyl / Cetyl / Stearyl / Behenyl), Dimerglinolic Acid Dimerglinoleil, Diisostearate Dimerglinoleil, Dimerglinoleil Hydrogenated Rosin Condensate, Dimerglinolic Acid Derivatives of dimeric acid or dimerdiol such as hardened castor oil, hydroxyalkyl dimer dichlorinorail ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA). ), Laurate diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitate monoethanolamide (partamide MEA), palmitate diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA) Fatty acid alkanolamides such as: dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, ( Aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyldimethicone and amodimethicone, cationic-modified silicones, polyether-modified silicones such as dimethiconecopolyol, polyglycerin Modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphate-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkylether-modified silicone, a. Minoic acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cationic-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, amide alkyl-modified silicone, aminoglycol-modified silicone, aminophenyl-modified Silicones such as silicones and polysiloxane / oxyalkylene copolymers; fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether are preferable. These can be used alone or in combination of two or more.

Examples of the moisturizing agent / feel improving agent include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, and the like. Polypolymers such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and its polymers; diethylene glycol monoethyl ether Glycol alkyl ethers such as (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, polyglyceryl-10 tetradecanedioate, cyclohexanedicarboxylic acid Water-soluble esters such as bisethoxydiglycol; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, martitol; glucose, fructose, galactose, mannose, treose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, Trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, Sugars and derivatives such as heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate , Caronine sulfate, keratosulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fluctanes such as inulin and levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; organic acids such as citrate, tartaric acid and lactic acid and salts thereof. Urea; Salts such as 2-pyrrolidone-5-carboxylic acid and sodium thereof; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threoni Amino acids such as peptides, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and their salts; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen degradation Peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degraded peptide, keratin-degraded peptide, hydrolyzed keratin, conchiolin-degraded peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean Protein peptides and derivatives thereof such as proteolytic peptides, wheat proteolytic peptides, hydrolyzed wheat proteins, casein-degrading peptides, acylated peptides; acylated peptides such as palmitoyl oligopeptides, palmitoyl pentapeptides, palmitoyl tetrapeptides; Peptides; Lactobacillus culture, yeast extract, eggshell membrane protein, submandibular gland mutin, hypotaurine, sesame lignan glycoside, glutathione, albumin, lactose; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extraction Peptides, Hamamelis water, Hechima water, Camomila extract, Kanzo extract, Comfrey extract, Silk extract, Izayoi rose extract, Peptide extract, Eucalyptus extract, Melilot extract and other animal / plant extracts, Natural ceramide (Types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides, sphingoglycolipids, ceramides and ceramides such as sugar ceramide-containing extracts are preferable. These can be used alone or in combination of two or more.

As the surfactant, anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymer surfactants and the like are preferable. The HLB of the surfactant is not particularly limited and can be used from a low HLB of about 1 to a high HLB of about 20, and it is also preferable to combine a low HLB and a high HLB. Examples of preferred surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulphates such as sodium lauryl sulphate, triethanolamine lauryl sulphate and ammonium lauryl sulphate; laureth. Polyoxyethylene alkyl sulfates such as sodium sulphate and triethanolamine laures sulphate; sodium cocoyl methyl taurine, potassium cocoyl methyl taurine, sodium lauroyl methyl taurine, sodium myristyl methyl taurine, sodium lauroyl methyl alanine, sodium lauroyl sarcosin, lauroyl sarcosin triethanol. Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroyl glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine. , Acylamino acid salts such as lysine Na dilauroyl glutamate; Polyoxyethylene alkyl ether acetates such as sodium laureth acetate; Sulfonic acid ester salts such as sodium lauroyl monoethanolamide succinate; Polyoxyethylene fatty amine sulfate; fatty acid alkanolamide sulfate; hardened coconut oil fatty acid fatty acid glyceride sulfate such as sodium glycerin sulfate; alkylbenzene polyoxyethylene sulfate; olefin sulfonate such as α-olefin sulfonate; Alkyl sulfosuccinates such as lauryl disodium acid, sodium dioctyl sulfosuccinate; alkyl ether sulfosuccinates such as laures disodium sulfosuccinate, monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; tetradecyl Alkyl benzene sulfonates such as sodium benzene sulfonate, triethanolamine tetradecyl benzene sulfonic acid; alkyl naphthalene sulfonate; alkane sulfonate; α-sulfo fatty acid methyl ester salt; acyl icethionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetate; Alkyl phosphate ester salts such as sodium laures phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooleth phosphate; Alkyl phosphate ester salts such as potassium lauryl phosphate; Sodium caseinate; Alkyl aryl ether Phosphate; fatty acid amide ether phosphate; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof; Anionic surfactants, etc .; Among nonionic surfactants, laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steares (polyoxyethylene stearyl ether), behenes (polyoxy) Polyoxyethylene alkyl ethers with various polyoxyethylene additions such as ethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether), octyldodeces (polyoxyethylene octyldodecyl ether); polyoxyethylene alkylphenyl ether; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, poly Oxyethylene hydrogenated castor oil and castor oil derivatives such as maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxy Polyethylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether, etc. Polyoxyethylene / polyoxypropylene alkyl ether; polyoxyethylene / polyoxypropylene glycol; (poly) glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; Glyceryl, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, coconut oil fatty acid glyceryl, monocotton oil fatty acid glycerin, glycerin monoercaate, glycerin sesquioleate, α, α'-glycerin oleate, monostearic acid Glycerin fatty acid partial esters such as acid glycerin malic acid; polyglyceryl-2, 3, 4, 4, 6, 8, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate- 2. Polyglyceryl decastearate-10, polyglyceryl isostearate-2, 3, 4, 4, 5, 6, 8, 10, 10, polyglyceryl diisostearate-2 (diglyceryl diisostearate), 3, 10, 10 , Polyglyceryl-2 triisostearate, Polyglyceryl-2 tetraisostearate, Polyglyceryl-10 decaisostearate, Polyglyceryl-2 oleate, 3, 4, 5, 5, 6, 8, Polyglyceryl dioleate- 6. Polyglycerin fatty acid ester such as polyglyceryl-2 trioleate, polyglyceryl-10 decaoleate; ethylene glycol monofatty acid ester such as ethylene glycol monostearate; propylene glycol monofatty acid ester such as propylene glycol monostearate; pentaerythritol moiety Fatite ester; sorbitol partial fatty acid ester; martitol partial fatty acid ester; martitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan Solbitan fatty acid esters such as trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; partial esters of sugar derivatives such as sucrose fatty acid ester, methylglucoside fatty acid ester, trehalose undecylate; Alkyl glucosides such as glucosides; alkyl polyglycosides; glycolipids such as mannosyl erythritol lipid; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene di Ole Polyoxyethylene fatty acid mono and diesters such as alcohol; polyoxyethylene / propylene glycol fatty acid ester; polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate, etc. Polyoxyethylene glycerin fatty acid esters such as monooleate; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate. Polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; poly Oxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol honey; alkyl glyceryl ethers such as isostearyl glyceryl ethers, chimil alcohols, ceracyl alcohols and batyl alcohols; polyhydric alcohol alkyl ethers; poly Oxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amides; coconut oil fatty acids monoethanolamide (cocamide MEA), coconut oil Fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitate monoethanolamide (partamide MEA), palmitate diethanolami Alcohol alkanolamides such as do (partamide DEA) and coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, behenamine oxide; alkylethoxydimethylamine Oxide; polyoxyethylene alkyl mercaptan; polyether such as dimethicone copolypoly Silicone-based nonionic surfactants such as cell-modified silicones, polysiloxane / oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones; among cationic surfactants, behentrimonium chloride and stealtrimonium chloride. Alkyltrimethylammonium chlorides such as cetrimonium chloride and lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; Fatty acid amidamines such as stearamide ethyl diethylamine and salts thereof; alkyl ether amines such as stearoxypropyl dimethylamine and salts thereof or quaternary salts; long-chain branched fatty acids ethyl sulfate (12-31) aminopropyl ethyl dimethyl ammonium, lanolin ethyl sulfate Fatty acid amide type quaternary ammonium salt such as fatty acid aminopropyl ethyl dimethyl ammonium; polyoxyethylene alkylamine and its salt or quaternary salt; alkylamine salt; fatty acid amide guanidium salt; alkyl etheraminemonium salt; alkyltrialkylene glycol Ammonium salt;
Benzarkonium salt; benzethonium salt; pyridinium salt such as cetylpyridinium chloride; imidazolinium salt; alkylisoquinolinium salt; dialkylmoriphonium salt; polyamine fatty acid derivative; aminomodified silicone such as aminopropyldimethicone and amodimethicone, Silicone-based cationic surfactants such as cation-modified silicones, cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones; among amphoteric surfactants, N- such as lauryl betaine (lauryl dimethylaminoacetic acid betaine) Alkyl-N, N-dimethyl amino acid betaine; fatty acids such as cocamidopropyl betaine and lauramide propyl betaine Alkyl-N, N-dimethyl amino acid betaine; imidazoline type betaine such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyldimethyltaurine and the like Alkyl sulfobetaine; Sulfate-type betaine such as alkyldimethylaminoethanol sulfate ester; Phosphate-type betaine such as alkyldimethylaminoethanol phosphate; Hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as lecithin hydroxide; silicone-based amphoteric surfactants, etc .; Polyvinyl alcohol, sodium alginate, starch derivatives, tragant gum, acrylate / alkyl methacrylate copolymers; various silicone-based surfactants are preferred. These can be used alone or in combination of two or more.

Examples of the polymer / thickener / gelling agent include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, farcerelan, karaya gum, trolley aoi, cara gum, tragant gum, pectin, pectic acid and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potatoes, wheat; xanthan gum, dextran, succinoglucan, curdran, hyaluronic acid and its salts, zansan gum, purulan, gellan gum, chitin , Chitosan, agar, casso extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts such as sodium thereof, methyl hydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethyl Ammonium sulfate cellulose, crystalline cellulose, cellulose powder and other cellulose and derivatives thereof; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch, hydroxypropyltrimonium chloride starch, corn starch aluminum octenyl succinate, etc. Alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpidridone / vinyl alcohol copolymer, polyvinylmethyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene Polyoxypropylene copolymer; amphoteric methacrylate copolymer such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrelites / stearyl acrylate / ethylamine methacrylate) copolymer; (dimethicone / vinyldimethicone) cloth Polymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; Acrylic resin alkanolamine; polyester, water-dispersible polyester; polya Crylamide; polyacrylic acid ester copolymer such as ethyl polyacrylate, carboxyvinyl polymer, salt such as polyacrylic acid and sodium salt thereof, acrylic acid / methacrylic acid ester copolymer; acrylate / alkyl methacrylic acid Polymers: cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid such as polyquaternium-39. -Diallyldimethylammonium chloride-acrylamide copolymer, acrylic acid-cationized metaacrylic acid ester copolymer, acrylic acid-cationized metaacrylic acid amide copolymer, polyquaterium-47 and other acrylic acid-methyl acrylate-chloride Methacrylate propyltrimethylammonium copolymer, choline chloride methacrylate polymer; cationized oligosaccharides, cationized dextran, cationized polysaccharides such as guarhydroxypropyltrimonium chloride; polyethyleneimine; cationic polymers; polyquaternium-51 and the like. 2-Polymer of methacryloyloxyethyl phosphorylcholine, polymer with butyl methacrylate copolymer, etc .; acrylic resin emulsion, ethyl polyacrylate emulsion, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic Polymer emulsions such as latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and Its salts; dextrin fatty acid esters such as dextrin palmitate, dextrin myristinate; silicic anhydride, fuming silica (ultrafine anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, metal dialkyl phosphate, Bentonite, hectrite, organically modified clay minerals, sucrose fatty acid esters, fructo-oligosaccharide fatty acid esters are preferred. These can be used alone or in combination of two or more.

Examples of solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyldiol. Kind: Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as: ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, glycol ether esters such as propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl Preferables include propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation freon; LPG, dimethyl ether, and carbon dioxide. These can be used alone or in combination of two or more.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; bisulfite derivatives such as propyl bisulfite; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; Sulfites such as sodium sulfite; hydrogen sulfites such as sodium hydrogen sulfite; thiosulfites such as sodium thiosulfite; metahydrosulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferable. Is listed as. As the reducing agent, thioglycolic acid, cysteine, cysteamine and the like are preferable. As the oxidizing agent, hydrogen peroxide solution, ammonium persulfate, sodium bromate, percarbonate and the like are preferable. These can be used alone or in combination of two or more.

Examples of antibacterial agents or preservatives include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane. 1,2-Alcandiols such as diols; Alkylglyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); Salicylic acid; Sodium benzoate; Isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; Linium urea; Dehydroacetic acid and its salts; Phenols; Halogenized bisphenols such as triclosan, acid amides, quaternary ammonium salts; Chlorhexidine acid, halocarban, hexachlorophenol, hinokithiol; other phenols such as phenol, isopropylphenol, cresol, timol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion However, when used as an antibacterial agent or an antiseptic for the purpose of antiseptic, from the viewpoint of safety of cosmetics or external preparations for skin, phenoxyethanol; 1,2-pentanediol, 1,2-hexane It is more preferable to use 1,2-alkanediols such as diols and 1,2-octanediols; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ethers. These can be used alone or in combination of two or more.

Examples of the chelating agent include edetates (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytate; ethidroic acid and the like. Phosphonic acid and salts such as sodium salts thereof; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphate; sodium citrate, citric acid, alanine, dihydroxyethylglycine , Gluconic acid, ascorbic acid, succinic acid, tartrate acid are preferred. As pH adjusters / acids / alkalis, citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amin, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Preferred are sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate and ammonium carbonate. These can be used alone or in combination of two or more.

Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, white mica, gold mica, synthetic mica, red mica, black mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, cay. Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (eg zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, dark blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide , Fine and ultrafine zinc oxide, alumina, silica, fumigant silica (ultrafine anhydrous silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine gold mica, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with silicones such as hydrogen silicone and cyclic hydrogen silicone or other surface treatment agents such as silane or titanium coupling agents to make them hydrophobic or Inorganic powder such as hydrophilized powder; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate -Polymethylmethacrylate laminated powder, polyethylene terephthalate, aluminum, epoxy laminated powder, etc., urethane powder, silicone powder, Teflon (registered trademark) powder, and other organic powders and surface treatment powders of various sizes and shapes, organic and inorganic Composite powders are preferred. Inorganic salts include sodium chloride-containing salts such as salt, normal salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, ginger, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, etc. Aluminum / potassium sulfate (myoban), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na / 2Na / 3Na phosphate, phosphoric acid Potassiums, calcium phosphates and magnesium phosphates are preferred. These can be used alone or in combination of two or more.

Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoate ethyl. An benzoic acid-based UV absorber such as ester, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; anthranylic acid-based UV absorber such as homomentyl-N-acetylanthranilate; salicylic acid And salicylic acid-based ultraviolet absorbers such as sodium salt, amylsalicylate, menthylsalicylate, homomentylsalicylate, octylsalicylate, phenylsalicylate, benzylsalicylate, p-isopropanol phenylsalicylate; octylcinnamate, ethyl-4-isopropylcinnamate, methyl. -2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy Synnamete, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (synoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Cyraxic acid-based ultraviolet absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate (octocrine), glycerylmono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and derivatives thereof; 2, 4-Dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-Methoxybenzophenone (oxybenzon-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' Benzophenones such as −phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone UV absorbers; 3- (4'-methylbenziliden) -d, l-phenyl, 3-benziliden-d, l-phenyl; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 -Methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoilmethane; 5-( 3,3-Dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octylriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate 2- (2'-Hydroxy-5'-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentandione, dimethoxybenzilidendioxoimidazolidine propionic acid Hydantin derivatives such as 2-ethylhexyl, phenylbenzimidazole sulfonic acid, terephthalylidene dicanfursulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives are preferred. These can be used alone or in combination of two or more.

Examples of vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxin hydrochloride, pyridoxin dioctanoate, pyridoxin dipalmitate, etc. Vitamin B group such as flavin adenin dinucleotide, cyanocobalamine, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin E such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate ester salt such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt, tetra ascorbic acid Ascorbic acid fatty acid ester such as isoparmic acid ester, ascorbic stearate, ascorbic palmitate, ascorbic dipalmitate, alkyl ether ascorbic acid such as ethyl ether ascorbic acid, ascorbic acid glucoside such as -2-glucoside ascorbic acid and its fatty acid ester , Ascorbic acid derivatives such as tocopheryl ascorbic acid; tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, tocopherol derivatives such as tocopherol phosphate, and other vitamin derivatives, tocotrienol, and other various vitamin derivatives are preferable. Is listed as. These can be used alone or in combination of two or more.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokithiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisolone, diphenhydramine hydrochloride, chlorpheniramine maleate; , Plant extracts such as Honoha extract are preferred. As hair growth agents, blood circulation promoters, and stimulants, plant extracts and tinctures such as senburi extract, togarashi tincture, ginger tincture, ginger extract, and cantarist tincture; , Borneol, cyclanderate, cinnaridine, trazoline, acetylcholine, verapamil, cepharanthin, γ-orizanol, cepharanthin, vitamin E and derivatives such as tocopherol nicotinate / tocopherol acetate, γ-orizanol, nicotinic acid and nicotinic acid amide / benzyl nicotinate. Derivatives such as ester inositol hexanicotinate and nicotine alcohol, allantin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivative, stigmasterol or stigmasterol and its glycoside, minoxidil are preferable. Is listed as. As the hormones, estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisolone and the like are preferable. Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cold sensitizers, warming agents, wound healing promoters, stimulant relievers, analgesics, cell activators, etc. include retinols, retinoic acids, retinoins. Tocopheryl acid; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and its glycosides / esterified products, hydroxycapric acid, long-chain α-hydroxy fatty acid, long-chain α-hydroxy fatty acid cholesteryl and other α- or β-Hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosin; creatin; ceramides, spingosins; caffeine, xanthin and its derivatives; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloids, fullerene and other antioxidants and active oxygen scavengers; catechins; quercetin and other flavones; isoflavones; Polyphenols such as anthocyanidin, chlorogenic acid, apple polyphenols; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; Glycoside, gingerol; fragrance substances such as menthol, camphor, sedrol and derivatives thereof; capsaicin, vanillin and derivatives; insect repellents such as diethyl toluamide; complexes of physiologically active substances and cyclodextrins are preferred. Can be mentioned. These can be used alone or in combination of two or more.

Plant / animal / microbial extracts include iris extract, acitaba extract, asunaro extract, asparagus extract, avocado extract, flaxseed extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract. , Inchikou extract, Uikyo extract, Ukon extract, Woolong tea extract, Uwaurushi extract, Agetsu extract, Echinashi leaf extract, Enmeisou extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otanenjinjin extract, Otogirisou extract, Odori kosou extract, Ononis extract , Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cucumber extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomogi Extract, crow wheat extract, calcade extract, kanzo extract, oil-soluble kanzo extract, kiwi extract, kiou extract, kikurage extract, kina extract, cucumber extract, kiri leaf extract, guanosine, guava extract, kujin extract, cutinashi extract, kumazasa extract, clara extract, walnut Extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, quail extract, gentiana extract, gennoshouko extract, tea extract, yeast extract, koboku extract, coffee extract, gobo extract, rice extract, rice Fermented extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, moss peach extract, saishin extract, psycho extract, saitai extract, saffron extract, salvia extract, sabonsou extract, sasa extract, sanzashi extract, sansha extract, sansho Extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Jatoba extract, Shakuyaku extract, Shokyu extract, Shobu root extract, Shirakaba extract, White chrysanthemum extract, Sugina extract, Stevia extract, Stevia fermented product, Nishikawayanagi extract, Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogirisou extract, Seiyouhakka extract, Sage extract, Zeniaoi extract, Senkyu extract, Senburi extract, Souhakuhi extract, Daiou extract, Dai Zu extract, Taisou extract, Thyme extract, Dandelion extract, Local clothing extract, Tea extract, Chouji extract, Chigaya extract, Chinpi extract, Tea tree oil, Jincha extract, Togarashi extract, Touki extract, Tokinsenka extract, Tounin extract, Tohi extract, Dokudami extract, Tomato Extract, Natto extract, Carrot extract, Carrot extract, Novara extract, Hibiscus extract, Bakumondou extract, Hass extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Paris etalia extract, Hikiokoshi extract, Bisaborol, Hinoki extract, Bifizus bacterium extract, Biwa extract, Fukitanpopo extract, Fukinotou extract, Bukuryo extract, Butcher bloom extract, Grape extract, Grape seed extract, Propolis, Hechima extract, Benibana extract, Peppermint extract, Bodaiju extract, Button extract, Hop extract, Maikaika extract, Pine extract, Maronie extract , Mizubasho extract, Mukuroji extract, Melissa extract, Mozuku extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yuzu extract, Yuri extract, Yokuinin extract, Yomogi extract, Lavender extract, Green tea extract, Eggshell membrane extract, Apple extract, Louis Boss tea extract , Reishi extract, lettuce extract, lemon extract, lotus extract, lotus extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, crackle extract and the like are preferable. These can be used alone or in combination of two or more.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, and pyridoxine. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate and the like. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid and the like. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease and the like. Preferred examples of nucleic acids include ribonucleic acid and a salt thereof, deoxyribonucleic acid and a salt thereof, and disodium adenosine triphosphate. These can be used alone or in combination of two or more.

As fragrances, acetylsedrene, amylcinnamaldehyde, allylamylglycolate, β-ionone, isoe super, isobutylquinolin, iris oil, iron, indol, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragor, Eugenol, Oak Moss, Opoponax Resinoid, Orange Oil, Eugenol, Oranthiol, Galaxolid, Carbachlor, L-Carbon, Kamfer, Cannon, Carrot Seed Oil, Clove Oil, Methyl Cylate, Geraniol, Geranyl nitrile , Isobornyl acetate, Geranyl acetate, Dimethylbenzylcarbinate acetate, Styralyl acetate, Cedril acetate, Telepinel acetate, pt-butylcyclohexyl acetate, Vetiberyl acetate, benzyl acetate, Linaryl acetate, Isopentyl salicylate, benzyl salicylate, Sandalwood oil, Santa roll, Cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citroneral, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylux Reginoid, Cedarwood Oil, Sedren, Sedrol, Celori Seed Oil, Thyme Oil, Damascon, Damasenon, Timor, Tuberose Absolute, Decanal, Decalactone, Terpineol, γ-Terpinen, Triplar, Nerol, Nonanar, 2,6-Nonadienor, Nonalactone, Pachori Alcohol, vanilla absolute, vanillin, basil oil, patcholi oil, hydroxycitroneral, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil, vetiverol , Peppermint oil, pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, muskketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menton, eucalyptus oil, β-yonone, lime oil , Lavender oil, D-limonen, linalol, lylar, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, synthetic fragrances such as various essential oils and natural Fragrances and various blended fragrances are preferred. These can be used alone or in combination of two or more.

Dyes / colorants / dyes / pigments include brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, and blue 204. , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 , Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1 , Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505 , Red 506, Orange 201, Orange 203, Orange 204, Orange 205, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202-1 , Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow Legal dyes such as No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p- phenylenediamine, HC Blue 2, Basic Blue 26 and other nitro dyes; Disperse dyes; Titanium dioxide, Zinc oxide Inorganic white pigments such as; Inorganic red pigments such as iron oxide (Bengala) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and ocher; Black iron oxide, low Inorganic black pigments such as next titanium oxide; Inorganic purple pigments such as mango violet and cobalt violet; Inorganic green pigments such as dye, chromium hydroxide, cobalt titanate; inorganic blue pigments such as ultramarine and dark blue; titanium oxide coated mica, titanium oxide coated oxybismus chloride, titanium oxide coated talc, colored titanium oxide coated mica, oxy Pearl pigments such as bismuth chloride and fish scale foil; metal powder pigments such as aluminum powder, copper powder and gold; surface-treated inorganic and metal powder pigments; red 201, red 202, red 204, red 205, red 220 , Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404, Red 3, Red 104, Red 106, Red 227, Red Organic pigments such as zirconium, barium or aluminum lakes such as 230, red 401, red 505, orange 205, yellow 4, yellow 5, yellow 202, yellow 203, green 3 and blue 1. Surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsantin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, naphthoquinones such as ciconin, bixin, flavones, beta Natural pigments and dyes such as cyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5- Oxidation dye intermediates and couplers such as amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and salts thereof; auto-oxidation dyes such as indolin; dihydroxyacetones are preferred. These can be used alone or in combination of two or more.

As the water, in addition to normal water and purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionized water, electrolytically acidic ionized water, ionized water, and cluster water are preferable. These can be used alone or in combination of two or more.

In addition to these, cosmetic raw material standards, compounding ingredient standards by cosmetic type, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), pharmaceutical non-pharmaceutical raw material standards, Japanese Pharmacy, pharmaceutical additives Ingredients described in standards, official food additive official documents, etc., and Japanese and foreign patent gazettes and patent publication gazettes (including publication gazettes and republications) whose international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the described ingredients, in known combinations, blending ratios, and blending amounts. These can be used alone or in combination of two or more.

Examples of the type of cosmetics of the present invention include hair cosmetics, basic cosmetics, make-up cosmetics, aromatic cosmetics, body cosmetics, skin external preparations such as ointments, and the like. From the viewpoint of exerting the effects of the present invention, it can be particularly preferably used for hair cosmetics and basic cosmetics. The cosmetic of the present invention can be produced according to a usual method.

Explaining the types of the cosmetics of the present invention in more detail, the hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, shampoos for indulgence, shampoos for hair coloring, shampoos such as rinse-integrated shampoos; rinses, treatments, Conditioners such as hair packs and hair mists; hair styling products such as hair foams, hair mousses, hair sprays, hair waxes, hair gels, hair creams, water greases, set lotions, pomades, tics; color lotions, hair tonics, hair liquids, hair blows, branches Hair coats, hair oils, permanent wave agents, straight perms, oxidative hair dyes, hair bleaches, hair color pretreatments, hair color aftertreatments, perma pretreatments, perma aftertreatments, hair manicures, and hair restorers are preferred. Be done.

Basic cosmetics include softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisturizer, moisturizer. -Emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sun screen, make-up lotion, horny smoother, elbow lotion, hand lotion, body lotion and other emulsions; emollient cream, nutrition cream, Nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, make-up cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening Creams such as creams; Gels such as moisture gels; Essences such as moisturizing essences, whitening essences, and UV protection essences; Lipstick cosmetics such as liposome beauty liquids and liposome cosmetics; Peel-off packs, powder packs, washing packs, oil packs, cleansing Packs and masks such as masks; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, cleansing powder, facial cleansing powder, etc.; cosmetic soap, transparent soap, medicated soap, liquid soap, Soaps such as shaving soaps and synthetic cosmetic soaps are preferred.

As makeup cosmetics, white powder / dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment are preferable. ..

Preferable aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, cologne, perfume paste, fragrance powder, perfume soap, body lotion, and bath oil.

Body cosmetics include body cleaners such as body shampoo, deodorant lotions, deodorant powders, deodorant sprays, deodorant cosmetics such as deodorant sticks, depigmenting agents, depilatory / depilatory agents, bathing agents, insect repellent sprays, etc. Repellers are preferred.

Further, as the external preparation for skin, it can be used in a dosage form such as an ointment, a patch, a lotion, a liniment, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

As the dosage form of the cosmetic or skin external preparation of the present invention, emulsification of oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type and the like. Type cosmetics, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste-like cosmetics, stick-like cosmetics, volatile oil-type cosmetics, powder-like cosmetics, jelly-like cosmetics, gel-like cosmetics, paste-like Pharmaceutical types such as cosmetics, emulsified polymer type cosmetics, sheet-like cosmetics, mist-like cosmetics, and spray-type cosmetics are preferable.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

Average degree of polymerization and degree of polymerization distribution of levan composition In the present invention, the average degree of polymerization was calculated based on the weight average molecular weight (standard substance pullulan) obtained by GPC measurement. The degree of polymerization distribution was calculated from the retention times of peak rise and fall. The GPC measurement conditions are as follows.
Column: TOSOH TSK-GEL G3000PWXL + G2500PWXL (7.8 x 300 mm each)
Solvent: 50 mM sodium nitrate Flow rate: 0.5 mL / min Temperature: 40 ° C
Detector: Differential refractometer

Production Example 1 Preparation of levan composition The concentration of the sugar solution as a raw material was adjusted to 40% by mass, Bacillus subtilis culture solution was added at 37 ° C., and an enzymatic reaction was carried out for 4 days with gentle stirring. The reaction was terminated when the remaining amount of sugar reached about 10% by mass in the sugar composition. The reaction completion liquid was purified through a decolorization step by activated carbon filtration, a removal step of low molecular weight sugars by a reverse osmosis membrane, and a desalting step by an ion exchange resin, and freeze-dried to obtain a powder having a purity of 95% or more. When the degree of polymerization of levan thus obtained was analyzed, it was found that the average degree of polymerization was 14, and levan having a degree of polymerization of 5 to 60 was contained in an amount of 95% by mass or more.

Evaluation of promotion of epidermal hyaluronic acid production The epidermal hyaluronic acid production promotion evaluation was performed on the levan composition of Production Example 1 and the levan composition derived from Erwinia herbicola (average degree of polymerization 400, manufactured by Sigma-Aldrich). After culturing normal human epidermal cells for 48 hours in the medium to which the sample was added at each concentration shown in Table 1, the amount of hyaluronic acid in the medium supernatant was quantified by the ELISA method. Table 1 also shows the quantitative results and the hyaluronic acid production promotion rate (calculated assuming that the amount of hyaluronic acid when cultured in the medium without the hyaluronic acid production promoter of the present invention is 100% by mass).

Evaluation of dermal hyaluronic acid production promotion The dermal hyaluronic acid production promotion evaluation was performed on the Levan composition of Production Example 1 and the Levan composition derived from Erwinia herbicola (average degree of polymerization 400, manufactured by Sigma-Aldrich). After culturing normal human skin fibroblasts for 48 hours in the medium to which the sample was added at each concentration shown in Table 2, the amount of hyaluronic acid in the medium supernatant was quantified by the ELISA method. Table 2 also shows the quantitative results and the hyaluronic acid production promotion rate (calculated assuming that the amount of hyaluronic acid when cultured in the medium without the hyaluronic acid production promoter of the present invention is 100% by mass).

From the results in Tables 1 and 2, the amount of hyaluronic acid in each of the levan compositions used in the test was significantly increased as compared with the case where no addition was added, and an excellent hyaluronic acid production promoting action was obtained in both the epidermis and the dermis. It turned out that there is.

Solubility Evaluation A solubility test was conducted on the levan composition of Production Example 1 and the levan composition derived from Erwinia herbicola (average degree of polymerization 400, manufactured by Sigma-Aldrich). The solubility in water at 25 ° C. was evaluated at each concentration shown in Table 3. The results are also shown in Table 3.

From the results in Table 3, it was found that the levan composition of Production Example 1 was superior in solubility in water as compared with the levan composition derived from Erwinia herbicola.

Usability evaluation For the levan composition of Production Example 1 and the levan composition derived from Erwinia herbicola (average degree of polymerization 400, manufactured by Sigma-Aldrich), the usability when a 0.1% (w / w) aqueous solution was applied to the skin. evaluated. The evaluation was based on the sensuality of seven panelists and evaluated according to the following evaluation criteria. The results are shown according to the following criteria based on the average score. The results are shown in Table 4.
<Sticky feeling at the time of application>
I don't feel it at all: 5 points I don't feel much: 4 points Normal: 3 points I feel a little: 2 points I feel very much: 1 point <Smooth feeling after drying>
Very feel: 5 points Slightly feel: 4 points Normal: 3 points I don't feel much: 2 points I don't feel at all: 1 point <Familiar with the skin>
Very feel: 5 points Slightly feel: 4 points Normal: 3 points I don't feel much: 2 points I don't feel at all: 1 point Judgment criteria [Average score]: [Judgment]
4.5 or higher: ◎
3.5 or more and less than 4.5: ○
1.5 or more and less than 3.5: △
Less than 1.5: ×

From the results in Table 4, it was found that the levan composition of Production Example 1 was superior in usability as compared with the levan composition derived from Erwinia herbicola.

Using the levan composition of Production Example 1, the cosmetics described below were prepared. All of the obtained cosmetics were excellent in hyaluronic acid producing effect, and high moisturizing property could be obtained. In addition, it fits well on the skin, suppresses stickiness during application, and the dry skin has a smooth and excellent feeling of use. Furthermore, it was intended to improve fine wrinkles due to drying.

(Example 1)
Whitening emulsion
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Plandoll-DP (Nippon Fine Chemical Co., Ltd.) 1.0
Cetyl ethylcaproate (Nippon Fine Chemical Co., Ltd.) 10.0
Cetanol 1.2
Phenyltrimethicone 3.0
Methylparaben 0.1
Myristyl Alcohol 2.0
Oleyl alcohol 1.0
Part B Stearoxy hydroxypropyl Methyl Cellulose 0.1
Xanthan gum 0.1
Levan composition of Production Example 1 0.1
Purified water 20.0
Part C Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Pentylene glycol 3.0
Glycerin 8.0
Part D 3-O-ethylascorbic acid (VC ethyl: Nippon Fine Chemical Co., Ltd.) 1.0
Purified water 5.0
Part E Phenoxyethanol 0.2
Methylparaben 0.15
Phytic acid 0.5
Citric acid 0.1
Amount of sodium citrate pH 4.5 Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− −−−−−−
(Preparation method)
Parts A and E were each heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was heated to about 70 ° C. and dispersed uniformly. After adding part A while stirring part C with a homodisper, part E was added while stirring. Parts D and B were added at about 50 ° C., and the mixture was stirred and uniformly dissolved.

(Example 2)
Emulsion
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Phytocompo-C (Nippon Fine Chemical Co., Ltd.) 1.0
Hydrogenated lysolecithin (LP70H: Nippon Fine Chemical Co., Ltd.) 0.1
Part B Triethylhexanoin (IOTG: Nippon Fine Chemical Co., Ltd.) 3.0
LUSPLAN SR-DM4 (Nippon Fine Chemical Co., Ltd.) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Setostearyl alcohol 1.0
Arachidyl alcohol 0.1
Jojoba Alcohol 3.0
Kimil alcohol 0.3
Ceraquil Alcohol 0.1
Hexildecanol 0.5
Part C Hydroxyethyl Acrylate / Acryloyl Dimethyltaurine Na) Copolymer 0.2
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.03
Levan composition of Production Example 1 0.2
Carbomer 0.1
Purified water 20.0
Part D Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.5
Acetylglucosamine 0.1
Polyquaternium-51 1.0
Ascorbic Glucoside 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

(Example 3)
Skin care cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Glycerin 9.0
DPG 5.0
Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Part B Vaseline 10.0
Pentaerythrityl tetraisostearate 5.0
Astaxanthin 0.01
Cetyl PG hydroxyethyl palmitamide 0.05
Cyclic lysophosphatidic acid Na 0.01
Dipentaerythrityl hexahydroxystearate 1.0
Part C Levan composition of Production Example 1 0.03
Carbomer 0.1
Hydroxide K 0.07
Xanthan gum 0.1
Purified water 10.0
Part D Phenoxyethanol 0.4
Ethylhexyl glycerin 0.2
Methylparaben 0.05
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

(Example 4)
Skin care cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Squalene 10.0
Stearic acid 1.0
Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 1.0
Phosphatidylinositol 0.1
Macadamia nut oil 3.0
Hydrogenated rapeseed oil alcohol 2.0
Olive oil fatty acid cetearyl 1.0
Olive oil fatty acid sorbitan 0.8
Polyglyceryl oleate-10 1.0
Part B Levan composition of Production Example 1 0.05
Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.07
(Acryloyl dimethyl taurine ammonium /
Behenes Methacrylic Acid-25) Cross Polymer 0.2
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Purified water 10.0
Hydrolyzed polyγ-glutamic acid K 0.1
Polyglutamic acid Na 0.1
Oligopeptide-24 0.05
Part C Glycerin 9.0
Propanediol 10.0
PEG-8 5.0
Methylparaben 0.1
Phenoxyethanol 0.3
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and C were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part B was mixed and stirred to give a viscous liquid. Part C was added while stirring with a homomixer, and part A was emulsified. After cooling, part B was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

(Example 5)
Skin care cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 1.0
Paraffin wax 3.0
Shea butter 3.0
Squalene 8.0
Cetanol 1.8
Hydrogenated cocoglyceryl 0.8
Glyceryl stearate 1.0
Behenyl alcohol 1.5
Sorbitan stearate 1.0
Methyl Glucose Sesquistearate 1.5
Part B Levan composition of Production Example 1 0.3
Xanthan gum 0.1
Hydroxyethyl cellulose 0.1
Crystalline cellulose powder 0.3
Stearoxy hydroxypropyl methylcellulose 0.1
Purified water 20.0
Part C Glycerin 8.0
DPG 5.0
Sorbitol 2.0
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and C were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part B was mixed and stirred to give a viscous liquid. Part C was added while stirring with a homomixer, and part A was emulsified. After cooling, part B was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

(Example 6)
Skin care cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Glycerin 9.0
Phytocompo-C (Nippon Fine Chemical Co., Ltd.) 1.0
Arginine hexyldecyl phosphate 0.3
Glucosylrutin 0.001
Part B Argania Spinosa Nuclear Oil 1.0
Theobroma Grange Florum Seed Fat 1.0
Astaxanthin 0.005
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical Co., Ltd.) 0.1
Ethylhexyl stearate 3.0
Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 2.0
Carnauba wax 0.5
Stairless-2 2.5
Stairless-21 1.8
Cetanol 3.0
Tocopherol acetate 0.03
Squalene 3.0
Part C carbomer 0.1
Levan composition of Production Example 1 0.05
Arginine 0.1
Hydroxypropyl chitosan 0.2
Ethanol 3.0
Purified water 10.0
Panthenol 0.5
Retinol palmitate 0.05
Part D Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

(Example 7)
Skin care cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Glycerin 12.0
BG 6.0
Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 2.5
Part B Olive Fruit Oil 3.0
Olive oil 1.5
Shea fat 1.0
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical Co., Ltd.) 3.0
Sucrose stearate 0.8
Cetearyl glucoside 1.2
Behenyl alcohol 1.5
Ascorbic Tetrahexyl Decanoate 7.0
Lauroyl sarcosine isopropyl 2.0
Hydrogenated cocoglyceryl 3.0
Cetanol 2.5
Sorbitan stearate 0.8
Cetyl phosphate 0.4
Bacil alcohol 0.3
Part C xanthan gum 0.05
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Glucosamine 0.1
Tuberose polysaccharide 0.01
Levan composition of Production Example 1 0.1
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
Sodium metabisulfite 0.03
Arbutin (Nippon Fine Chemical Co., Ltd.) 1.0
Tranexamic acid (Nippon Fine Chemical Co., Ltd.) 1.0
Part D Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.0
Propanediol 3.0
Methylparaben 0.1
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

(Example 8)
Skin care cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A jojoba oil 2.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-MCT (Nippon Fine Chemical Co., Ltd.) 3.0
LUSPLAN DD-DHR (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 1.3
Propylene glycol stearate 0.6
Squalene 3.0
Behenyl alcohol 2.0
Disetyl Phosphate 0.2
Ethylparaben 0.1
Liquid isoparaffin 0.5
Carnauba wax 0.3
Corn oil 0.3
Canola oil 1.0
Sunflower oil 1.0
Wheat germ oil 1.0
Flaxseed oil 0.1
Cottonseed oil 0.1
Soybean oil 0.1
Shea fat 0.5
Stigmasterol 1.0
Stannole 1.0
Dihydrocholesterol 0.1
Lanosterol 0.1
Dihydrolanosterol 0.1
Cholesteryl nonanoate 0.1
Cholesteryl stearate 0.1
Cholesteryl isostearate 1.0
Cholesteryl oleate 0.1
Cholesteryl 12-hydroxystearate 0.1
Long-chain branched fatty acid cholesteryl 0.3
Octyldodecyl myristate 1.0
Octyldodecyl isostearate 1.0
Dimeric linoleic acid hardened castor oil 1.0
Hydroxyalkyl dimer dilinoleyl ether 1.0
Tetra (hydroxystearic acid / isostearic acid)
Dipentaerythrityl 0.5
Rice bran oil fatty acid phytosteryl 0.5
Phenyltrimethicone 1.0
Diphenyldimethicone 1.0
Methyl Hydrogen Polysiloxane 1.0
Polyglyceryl-3 polydimethylsiloxyethyl dimethicone 0.5
Sugar-modified silicone 0.3
Polyoxyethylene / methylpolysiloxane copolymer 1.0
Tocopherol ferulate 0.1
Tocopherol phosphate 0.1
Tocotrienols 0.1
Tannin 0.01
Sesamin 0.01
Proanthocyanidins 0.01
Gravlysin 0.01
Grablen 0.01
Liquiritin 0.01
Isoliquilithin 0.01
Lactoferrin 0.01
Shogaol 0.01
Gingerol 0.01
Part B (acryloyl dimethyl taurine /
Behenes methacrylic acid-25) Copolymer 0.2
Crystalline cellulose 0.1
Levan composition of Production Example 1 0.05
Gellan gum 0.1
Carboxyvinyl polymer 0.1
Hydroxide K 0.08
Purified water 20.0
Part C Phytocompo-PP 1.0
Polyglyceryl stearate-10 0.5
Lysolecithin 0.05
Hydrogenated egg yolk lecithin 0.1
Glycerin 7.0
DPG 7.0
Part D Citric acid 0.07
Appropriate amount of Na citrate EDTA-2Na 0.05
Pentetic acid 5Na 0.03
Methylparaben 0.1
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was mixed and heated to about 70 ° C. to uniformly dissolve. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. to uniformly disperse. Part D was mixed and heated to about 70 ° C. to uniformly dissolve. Part A was added to part C with stirring with a homogenizer, and then part D was added for emulsification. After cooling, part B was added at about 50 ° C., and the mixture was stirred and uniformly dissolved.

(Example 9)
Skin care cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Plandoll-G (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.5
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 8.0
Diisopropyl sebacate (Nippon Fine Chemical Co., Ltd.) 2.0
Theobroma Grange Florum Seed Fat 3.0
Bacil isostearate 2.0
Shea fat 3.0
Isostearyl pivalate 0.1
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical Co., Ltd.) 0.1
Ethylparaben 0.2
Stearyl alcohol 3.5
Cetanol 1.3
Polyglyceryl distearate-3 methyl glucose 0.8
Tocopherol 0.1
Ascorbic Tetrahexyl Decanoate 8.0
Tocopheryl phosphate ascorbic 2.0
Placenta extract 1.0
Oryzanol 0.3
Phytosphingosine 0.0001
Ubiquinone 0.03
Carotene 0.05
Lycopene 0.01
Astaxanthin 0.01
Lutein 0.01
Peanut oil 0.1
Rice bran oil 1.0
Hydrogenated castor oil 0.3
Jojoba oil 2.0
Orange roughy oil 1.0
Liquid lanolin (Nippon Fine Chemical Co., Ltd.) 1.0
Purified lanolin (Nippon Fine Chemical Co., Ltd.) 1.0
Polyoxyethylene lanolin 1.0
Lanolin alcohol (lanolin alcohol A: Nippon Fine Chemical Co., Ltd.) 0.3
Lanolin acetate alcohol 0.1
Cholesteryl acetate 0.1
Octocrylene 0.5
Sorbitan sesquistearate 1.2
Part B Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.05
Tuberose polysaccharide 0.01
Levan composition of Production Example 1 0.1
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
2-methacryloyloxyethyl phosphorylcholine
Butyl methacrylate copolymer solution 0.05
Glutathione 0.3
4- (4-Hydroxyphenyl) -2-butanol 1.5
Butyl resorcinol 1.5
Arbutin (Nippon Fine Chemical Co., Ltd.) 3.0
Ascorbic Phosphate Mg 1.0
Part C Propanediol 10.0
Glycerin 7.0
Diglycerin 1.0
Sodium metabisulfite 0.1
Imidazolenium urea 0.1
Polyvinylpyrrolidone 0.1
Pullulan 0.1
Polyvinyl alcohol 0.1
Dehydroacetic acid 0.1
PEG-32 1.0
Polyglycerin 1.0
Pentetic acid 5Na 0.05
Appropriate amount of succinic acid and sodium succinate Amount of purified water totaling 100 -------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was made uniform using a part of purified water. Part C was heated to about 70 ° C. and dispersed. While stirring with a homomixer at about 70 ° C., part A was gradually added to part C for emulsification, cooled to about 40 ° C., part B was added, and the mixture was uniformly mixed.

(Example 10)
hand cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Lanolin Fatty Acid Cholesteryl (YOFCO CLE-S: Nippon Fine Chemical Co., Ltd.) 5.0
LUSPLAN SR-DM4 (Nippon Fine Chemical Co., Ltd.) 0.1
Squalene 8.0
Macadamia nut oil 0.5
Rosehip oil 1.0
Meadowfoam oil 1.0
Vaseline 15.0
Microcrystalline wax 2.0
Glyceryl stearate 2.0
Cetanol 2.0
Cetyl phosphate 1.0
Beeswax 3.0
Propylparaben 0.1
Tocopherol 0.05
Perfluoropolyether 1.0
Part B Levan composition of Production Example 1 0.05
Glycerin 8.0
Propanediol 5.0
Methylparaben 0.1
Ethylhexyl glycerin 0.5
Phenoxyethanol 0.3
Na hydroxide 0.5
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part B was heated to about 70 ° C. and dissolved. Part A was placed in another container and heated to about 80 ° C. to dissolve it. Part A was added to part B with stirring with a homomixer and emulsified. After emulsification, it was cooled to about 40 ° C.

(Example 11)
hand cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Plandoll-G (Nippon Fine Chemical Co., Ltd.) 0.5
(Dimethicone / Vinyl Dimethicone) Cross Polymer 0.3
(Vinyl Dimethicone / Lauryl Dimethicone) Cross Polymer 0.5
(Dimethicone / PEG-10 / 15) Crosspolymer 0.5
(PEG-15 / Lauryl Dimethicone) Cross Polymer 0.2
(Alkyl acrylate / dimethicone) copolymer 0.1
Cetyl ethylcaproate (NS-CIO: Nippon Fine Chemical Co., Ltd.) 10.0
Propylparaben 0.1
Squalene 5.0
Part B Diglycerin 5.0
Methylparaben 0.1
Levan composition of Part C Production Example 1 0.1
Xanthan gum (2% aqueous solution) 10.0
(Acrylamide / Ammonium Acrylate) Copolymer 0.5
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
After dissolving part B, part A was added and heated to about 70 ° C. (part D). The temperature of part C was about 70 ° C. Part C was added to part D with stirring, and the mixture was stirred and mixed with a homomixer for about 3 minutes. After mixing uniformly, it was cooled to about 40 ° C.

(Example 12)
hand cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Squalene 10.0
Vaseline 20.0
Polyglyceryl pentastearate-10 2.0
Microcrystalline wax 4.0
Stearoyl Lactate Na 1.3
Al 1.5 stearate
Mg stearate 1.0
Ca 0.1 stearate
Part B Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-DP (Nippon Fine Chemical Co., Ltd.) 0.8
Cetyl ethylcaproate (NS-CIO: Nippon Fine Chemical Co., Ltd.) 5.0
Triethylhexanoin (IOTG: Nippon Fine Chemical Co., Ltd.) 6.0
Propylparaben 0.05
Tocopherol 0.05
Cyclopentasiloxane 5.0
Part C Levan composition of Production Example 1 0.05
Methylparaben 0.1
Glycerin 10.0
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Each of parts B and C was heated to about 80 ° C. and dissolved. Part A was placed in another container, heated to 100 to 120 ° C., transparent gelled, and cooled to 80 ° C. Part B was added to part A with stirring, and part C was further added for emulsification. After mixing uniformly, it was cooled to about 40 ° C.

(Example 13)
Emulsion
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Phytocompo-SP (Nippon Fine Chemical Co., Ltd.) 8.0
Lysolecithin (LP70H: Nippon Fine Chemical Co., Ltd.) 0.1
Part B Squalene 4.0
Tri (caprylic acid / capric acid) glyceryl (Nippon Fine Chemical Co., Ltd.) 4.0
α-olefin oligomer 2.5
Cyclopentasiloxane 3.5
Cetanol 1.5
Glyceryl stearate 1.0
Levan composition of Part C Production Example 1 0.1
Hydroxyproline 0.05
Citric acid 0.01
Na citrate 0.09
Arbutin (Nippon Fine Chemical Co., Ltd.) 3.0
Phenoxyethanol 0.3
Methylparaben 0.1
Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.1
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A to C were taken, heated to about 70 ° C., and mixed uniformly. Part B was gradually added to part A while stirring with a homodisper, and then part C was added at about 70 ° C. for emulsification. Then it was cooled to about 40 ° C.

(Example 14)
Gel lotion
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 0.5
Glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl behenate 0.8
Stearic acid 0.3
PEG-20 hydrogenated castor oil 0.1
Polyglyceryl oleate-10 0.1
Part B Phenoxyethanol 0.3
Levan composition of Production Example 1 0.2
Pullulan 0.2
Ethylhexyl glycerin 0.2
Poly HEMA Glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Hyaluronic acid Na 0.01
Carbomer 0.06
Hydroxide K 0.05
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated to about 70 ° C. and dispersed uniformly. Part B was mixed, stirred well, made uniform, and then heated to about 70 ° C. Part B was added to part A, stirred at about 70 ° C. using a homomixer, and cooled to about 40 ° C.

(Example 15)
Cleansing gel
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Plandoll-S (Nippon Fine Chemical Co., Ltd.) 1.0
Dihydrocholes-30 2.0
(Bellpole DC-30: Nippon Fine Chemical Co., Ltd.)
LUSPLAN DD-IS (Nippon Fine Chemical Co., Ltd.) 8.0
PEG-25 hydrogenated castor oil 20.0
Octildo Decess-20 15.0
Glycerin 16.0
BG 5.0
Part B Levan composition of Production Example 1 0.01
Phenoxyethanol 0.5
Amount of purified water totaling 100 -------------
(Preparation method)
Part A is weighed and heated to about 80 ° C to dissolve. Weigh part B and heat to about 80 ° C. B was gradually added to A with stirring, and after mixing, the mixture was cooled to 40 ° C.

(Example 16)
Cleansing cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Glycerin 3.0
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-Aqualio (Nippon Fine Chemical Co., Ltd.) 1.0
Celesin 6.0
Mineral oil 28.0
PEG-12 isostearate 3.0
Sorbitan sesquioleate 1.5
Polyoxyethylene sorbitan oleate 0.3
Microcrystalline wax 2.0
Tocopherol 0.05
Propylparaben 0.05
Part B Levan composition of Production Example 1 0.05
DPG 5.0
Methylparaben 0.2
Edetonic acid 3Na 0.02
Phenoxyethanol 0.2
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was weighed and heated to about 80 ° C. to dissolve. Weigh part B and heat to about 80 ° C. B was gradually added to A with stirring, and after mixing, the mixture was cooled to 40 ° C.

(Example 17)
Facial cleansing foam
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A stearic acid K 10.0
Palmitic acid K 10.0
Myristic acid K 10.0
Lauric acid K 4.0
Lauroyl sarcosine isopropyl 0.8
PEG1500 10.0
Glycerin 15.0
Glyceryl monostearate 1.0
POE (20) Sorbitan Monostearate 2.0
Part B Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Levan composition of Production Example 1 0.05
Polyquaternium-7 0.5
Polyquaternium-39 0.5
Methylparaben 0.1
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was weighed and heated to about 80 ° C. to dissolve. Weigh part B and heat to about 80 ° C. B was gradually added to A with stirring, and after mixing, the mixture was cooled to 40 ° C.

(Example 18)
Facial cleansing foam
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Palm Fatty Acid / Hydrogenated Beef Tallow Fatty Acid) Na Glutamic Acid 30.0
Cocoyl glycine K 5.0
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.2
Lauric acid diethanolamide 3.0
Tocopherol 0.1
PEG-8 5.0
PEG-32 10.0
Glycerin 14.0
Propylparaben 0.1
Part B Methylparaben 0.2
Polyquaternium-51 1.0
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 0.5
Levan composition of Production Example 1 0.03
Crystalline cellulose 0.3
Polyquaternium-7 0.8
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was weighed and heated to about 80 ° C. to dissolve. Weigh part B and heat to about 80 ° C. B was gradually added to A with stirring, and after mixing, the mixture was cooled to 40 ° C.

(Example 19)
Body shampoo
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Cocoyl methyl taurine Na 10.0
Lauroyl hydrolyzed silk Na 6.0
Lauroylmethylalanine Na 10.0
Sodium cocoamphoacetate (30%) 4.0
Cocamidopropyl Betaine (30%) 10.0
Olefin (C14-16) Na Sulfonate 5.0
Polyquaternium-10 1.3
Guar Hydroxypropyltrimonium Chloride 0.8
Acetyl hyaluronic acid Na 0.02
Levan composition of Production Example 1 0.03
Cocamide DEA 3.0
Glycerin 5.0
Methylparaben 0.2
Amount of purified water totaling 100 -------------
(Preparation method)
All components were heated at about 80 ° C. and uniformly stirred and mixed.

(Example 20)
Non-silicone shampoo
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.03
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.1
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 0.5
Laureth-4 Carboxylic Acid Na (28%) 10.0
Laureth-6 Carboxylic Acid 4.0
Cocamidopropyl Betaine (30%) 10.0
Lauroylmethylalanine Na (30%) 5.0
Cocamidomethyl MEA 3.0
Coconut oil fatty acid PEG-7 glyceryl 5.0
Na hydroxide 1% solution 0.5
Levan composition of Production Example 1 0.02
Polyquaternium-10 0.8
Glycol distearate 0.5
Polyquaternium-7 0.5
EDTA-2Na 0.05
Methylparaben 0.2
Phenoxyethanol 0.4
Amount of purified water totaling 100 -------------
(Preparation method)
All components were heated at about 80 ° C. and uniformly stirred and mixed.

(Example 21)
hand soap
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A cocoyl isetionate Na 1.0
Glycerin 50.0
Levan composition of Production Example 1 0.02
Lauroyl sarcosine salt 12.0
Myristoylation Methyl Taurine Sodium 2.0
Polyglyceryl laurate-6 2.0
Coconut oil fatty acid diethanolamide 2.0
PEG-7 coconut oil fatty acid glyceryl 2.0
Nitrocellulose 0.1
Sorbitol 8.0
Conchiolin Degrading Peptide 0.1
1,3-butylene glycol 8.0
Phenoxyethanol 0.8
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved.

(Example 22)
Non-rinse scalp / hair treatment
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Neosolue-Aqualio (Nippon Fine Chemical Co., Ltd.) 1.0
Ethanol 40.0
Glycyrrhetinic acid 0.02
PPG-3 Caprylyl Ether 0.3
γ-docosalactone, diethyl sebacate (Elcalactone DES: Nippon Fine Chemical Co., Ltd.) 1.5
PEG / PPG-20 / 20 Dimethicone 0.2
PEG-12 Dimethicone 0.4
Hydrogenated retinol 0.1
Trishexyldecanoic acid pyridoxine 0.05
Bisglyceryl ascorbic acid 0.3
Hexil 3-glyceryl ascorbic acid 0.3
Part B Triethanolamine 0.1
Amount of purified water totaling 100 (Acrylate / Alkyl acrylate (C10-30)) Crosspolymer 0.4
Carbomer 0.05
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
(Acryloyl dimethyl taurine ammonium / VP) copolymer 0.05
(Acryloyldimethyltaurine ammonium / Behenez methacrylic acid-25) Crosspolymer 0.1
Hydroxypropyl chitosan 0.1
Methylparaben 0.1
Phenoxyethanol 0.2
Part C Levan composition of Production Example 1 0.02
VC Ethyl (Nippon Fine Chemical Co., Ltd.) 0.05
Nicotinamide 0.3
Pyridoxine hydrochloride 0.1
Caffeine 0.1
Glucosyl trehalose 0.1
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A was heated to about 50 ° C. and dissolved. Next, part B was uniformly dispersed to obtain a viscous liquid. Part A was added to part B with stirring and mixed uniformly. Then part C was added and mixed uniformly.

(Example 23)
Hair treatment
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Dodecane 1.5
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 0.2
Candelilla wax 0.2
Cetyl Esters 0.3
Stearyl ethyl hexaneate 1.0
Cetearyl alcohol 3.5
PEG-200 0.5
Hydroxyethyl cellulose 0.4
Setrimonium chloride (30%) 1.0
Behentrimonium chloride (80%) 1.0
Trideces-6 0.3
BHT 0.03
Part B Levan composition of Production Example 1 0.02
Methylparaben 0.2
Citric acid 0.05
Amount of purified water totaling 100 Part C PPG-3 myristyl 0.5
Isodecyl neopentane (Nippon Fine Chemical Co., Ltd.) 1.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part B was heated to about 80 ° C. and dissolved. Part A was added to another container and heated to dissolve it. Part B was gradually added to part A and mixed uniformly. Part C was added with stirring at about 50 ° C. to make it uniform.

(Example 24)
Hair treatment that does not wash away
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Polyquaternium-37 2.0
Squalene 2.0
PPG-3 Caprylyl Ether 2.0
Microcrystalline wax 0.1
Lanolin alcohol 0.2
Montan wax 0.1
Polyethylene wax 0.1
Beeswax 0.1
Japan wax 0.2
Celesin 0.1
Dicapric acid PG 1.0
Almond oil 0.5
Ethylhexyl ethylhexanoate 1.0
Candelilla low extract 0.1
Octyldodecyl erucate 4.5
Tocopherol acetate 0.02
γ-docosalactone, tri (caprylic acid / capric acid) glyceryl (ercalactone MCT: Nippon Fine Chemical Co., Ltd.) 2.0
Dipentaerythrityl tripolyhydroxystearate 1.5
PPG-5 Phytosteryl 0.5
Glycerin 4.0
Sorbitol 2.0
Phenoxyethanol 0.5
Part B Levan composition of Production Example 1 0.02
Hydrolyzed conchiolin 0.1
Panthenol 0.1
Hydroxypropyltrimonium hyaluronate 0.01
Polyquaternium-11 0.2
Glycosyl trehalose 0.1
Glyceryl glucoside 0.3
Arginine 0.1
Part C Purified water Amount totaling 100 Hydroxypropyl starch phosphoric acid 1.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part C was uniformly dispersed and heated to about 80 ° C. Next, part A was heated to about 80 ° C. to dissolve it. Part C was added while stirring, and after mixing uniformly, the mixture was cooled to about 40 ° C. Then, each part B was added and mixed uniformly.

(Example 25)
Hair treatment that does not wash away
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Neosolue-Aqualio (Nippon Fine Chemical Co., Ltd.) 1.0
Ethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 1.0
Setrimonium chloride (25%) 2.8
Ranorin Row 1.0
PPG-3 Caprylyl Ether 1.0
Methyl heptyl myristate 0.5
Cetyl ethylhexanoate 0.3
Isononyl isononanoate 0.3
Tridecyl neopentaneate 0.5
Myristyl isooctanoate 0.3
Neopentyl glycol diethylcaproate 0.3
Isobutyl isostearate 0.3
Glyceryl triisostearate 0.3
Trimethylolpropane triisostearate 0.3
Broccoli seed oil 0.3
Sphinganin 0.01
Glycerin 1.0
Part B Methylparaben 0.1
Amount of purified water totaling 100 Phenoxyethanol 0.5
Part C Ceramide 1, Ceramide 2, Ceramide 3, Ceramide 5, Ceramide 6, Cholesterol,
Quotanium-33-containing composition (NanoRepair-CMC5: Nippon Fine Chemical Co., Ltd.)
5.0
Composition containing γ-docosalactone and soybean sterol (NanoRepair-EL: Nippon Fine Chemical Co., Ltd.) 1.0
Polyquaternium-6 0.6
Polyquaternium-7 0.4
Polyquaternium-39 0.5
Part D Levan composition of Production Example 1 0.02
Carrageenan 0.1
Hydroxypropyl chitosan 0.05
Hydroxypropyl Methyl Cellulose 0.1
Tuberose polysaccharide 0.1
Cationized guar gum 0.05
Purified water 20.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part B was heated to about 80 ° C. to dissolve it. Next, part A was heated to about 80 ° C. to dissolve it. Part D was dispersed to prepare a viscous liquid. Part A was added to part B with stirring, mixed uniformly, and then cooled to about 40 ° C. Next, parts C and D were added and mixed uniformly.

(Example 26)
Non-silicone hair treatment
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.5
Propanediol 3.0
Behenamide propyl dimethylamine 1.5
Cetanol 2.2
Stearyl alcohol 0.8
Hydrogenated rapeseed oil alcohol 0.5
Neopentyl glycol diethylcaproate 0.8
Jojoba seed oil 1.0
Glyceryl stearate 0.4
Propylparaben 0.1
Cocamide MEA 0.8
Hydroxyethyl urea 0.5
Dicaprilyl Carbonate 2.0
Caesarpinia Spinosa Hydroxypropyltrimonium Chloride 0.1
Rice bran wax 0.5
Glycerin 1.0
Part B Levan composition of Production Example 1 0.02
Methylparaben 0.1
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Lactic acid 0.4
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was uniformly mixed at about 80 ° C. Part B, which was set aside separately, was heated to about 60 ° C. to make it uniform. Part B was gradually added to part A with stirring, mixed uniformly, and then cooled to about 50 ° C.

(Example 27)
Non-silicone treatment
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Stearyl Alcohol 3.0
Behentrimonium chloride 1.0
Stealtrimonium chloride 0.5
Stearamidopropyl dimethylamine 0.1
Hydrogenated polyisobutene 1.0
Hydrogenated polydecene 0.6
Camellia seed oil 0.5
Dicaprilyl ether 3.0
Dilauroyl lysine Na 0.1
Ascorbyl dipalmitate 0.1
BG 3.0
Tocopherol 0.1
Phenoxyethanol 0.4
Part B Na hydrogen carbonate 0.4
Amount of purified water totaling 100 Levan composition of Production Example 1 0.1
Locust Bean Hydroxypropyltrimonium Chloride 0.1
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part B was heated to about 80 ° C. and dissolved uniformly. Part A was added to another container and heated to dissolve it. Part B was gradually added to part A, mixed uniformly, and emulsified. It was cooled to about 40 ° C.

(Example 28)
Dandruff shampoo
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Lauroylmethylalanine Na (30%) 13.0
Cocamidopropyl Betaine (30%) 20.0
Cocoyl Glutamic Acid TEA (30%) 5.0
Cocamide DEA 1.0
Glycerin 1.0
Glyceryl caprylate 0.4
Glyceryl undecylenic acid 0.1
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Sorbitol 1.6
Miconazole nitrate 0.75
Glycol distearate 1.5
Polyquaternium-7 0.3
Part B Na benzoate 0.4
Na chloride 0.2
Amount of purified water totaling 100 Part C Swertia japonica extract 3.0
Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Polyquaternium-47 0.1
Piroctone olamine 0.1
Levan composition of Production Example 1 0.05
Purified water 9.7
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part B was heated to about 80 ° C. and dissolved uniformly. Part A was placed in a separate container and heated to dissolve it. Part B was gradually added to part A, mixed uniformly, and part C was added at about 60 ° C.

(Example 29)
shampoo
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A PPG-3 Caprylyl Ether 0.2
Ammonium Laureth Sulfate 5.0
Sodium Laureth Sulfate (25%) 10.0
Lauryl hydroxysultaine (30%) 10.0
Lauric acid K 1.0
Glycol distearate 0.5
Toluenesulfonic acid 0.3
Stearoxypropyl dimethylamine 0.5
PPG-17 0.3
Dimethicone 0.1
PEG-9 Dimethicone 0.1
Amodimethicone 0.1
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 1.0
Neopentyl glycol diethylcaproate 0.4
Lanolin fatty acid 0.3
Isodecyl glyceryl ether 0.4
Miconazole nitrate 0.75
Cocamide MEA 1.0
Laureth-4 0.3
Laureth-16 0.2
Stairless-6 0.2
Phenoxyethanol 0.3
Part B malic acid 0.1
Methylparaben 0.2
Phosphoric acid 0.03
Na benzoate 0.3
Amount of purified water totaling 100 Part C Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 3.0
Levan composition of Production Example 1 0.1
Purified water 6.6
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A was uniformly mixed at about 80 ° C. Part B, which was set aside separately, was heated to about 60 ° C. to make it uniform. Part B was gradually added to part A with stirring, mixed uniformly, and then cooled to about 50 ° C. Further, part C was added and mixed uniformly.

(Example 30)
mousse
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Ethanol 5.0
Polyethylene glycol oleyl ether (20) 1.0
Acrylic resin alkanolamine solution 3.0
Diethylaminopropylamide stearate 0.5
Pyrrolidone carboxylic acid 0.2
Levan composition of Production Example 1 0.1
Preservatives, fragrances 1.0
Amount of purified water totaling 100 -------------
(Preparation method)
The above components were mixed, and the obtained base and LPG were mixed at a ratio of base: LPG = 92: 8 to obtain an injection type mousse.

(Example 31)
Hair color treatment
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Neosolue-Aqualio (Nippon Fine Chemical Co., Ltd.) 1.0
Stealtrimonium chloride (70%) 2.5
Quotanium-33 (Cation NH: Nippon Fine Chemical Co., Ltd.) 0.3
Cocamide DEA 1.0
Inulin stearate 0.5
Lanolin alcohol 0.2
Montan wax 0.1
Polyethylene wax 0.1
Beeswax 0.1
Dextrin palmitate 0.3
Celesin 0.1
Decanoate PPG-3 1.0
Dicapric acid PG 1.0
Ethylhexyl ethylhexanoate 1.0
Dicaprilyl Carbonate 1.5
Glycerin 4.0
Setes-7 1.0
Isostearyl alcohol 0.3
Rice bran oil 0.5
Glyceryl stearate 0.5
γ-docosalactone, diethyl sebacate (Elcalactone DES: Nippon Fine Chemical Co., Ltd.) 1.5
Hydrogenated polydecene 0.1
Macadamia nut fatty acid ethyl 1.0
Lysine dilauroyl glutamate Na 0.1
Behendimonium stearyl ethyl phosphate 0.1
Tocopherol 0.05
Phenoxyethanol 0.3
Part C purified water 10.0
BG 2.0
Acylated hydrolyzed collagen 0.1
Panthenol 0.1
Hydroxyethyl cellulose 0.1
Polyquaternium-64 0.1
Polyquaternium-51 0.01
Polyquaternium-49 0.2
Phenoxyethanol 0.4
PCA-Na 0.1
Part D Purified water Amount totaling 100 Basic blue 99 0.1
Basic tea 16 0.13
HC Blue 2 0.05
HC Yellow 2 0.03
HC Red 3 0.1
Levan composition of Production Example 1 0.1
Hydroxyethyl urea 0.5
Arginine 0.2
Ammonium bicarbonate 1.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A, which had been uniformly mixed in advance, was added to part B and heated to about 80 ° C. to dissolve it (part E). Part D was heated to about 80 ° C. in another container to dissolve it. While stirring the D part in the E part, the mixture was gradually added and uniformly mixed, and then rapidly cooled (F part). Part C was added to part F at about 40 ° C. to make it uniform.

(Example 32)
Hair manicure
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ethanol 10.0
Carnauba wax 0.01
Setes-10 1.0
γ-docosalactone, diethyl sebacate (Elcalactone DES: Nippon Fine Chemical Co., Ltd.) 2.5
PPG-3 Caprylyl Ether 1.0
Isodecyl neopentane (Nippon Fine Chemical Co., Ltd.) 1.0
Decanoate PPG-3 0.5
Dicapric acid PG 0.5
Dicaprilyl Carbonate 0.5
Part B Purple 401 0.2
Black 401 0.1
Orange 205 0.1
Red 102 0.1
Citric acid 2.0
Benzyl alcohol 8.0
Ethanol 10.0
Part C Purified water Amount totaling 100 (Acryloyldimethyltaurine ammonium / VP) Copolymer 3.0
Glycolic acid 2.0
Levan composition of Production Example 1 0.05
Hydroxypropyl xanthan gum 0.2
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Parts A and C were mixed and made uniform. Part B was added to part C with stirring and mixed uniformly, then part A was added at about 60 ° C. and mixed uniformly.

(Example 33)
lipstick
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 10.0
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 10.0
Mineral oil 10.0
Triethylhexanoin (IOTG: Nippon Fine Chemical Co., Ltd.) 10.0
Octyldodecanol 5.0
LUSPLAN DD-DA5 (Nippon Fine Chemical Co., Ltd.) A total amount of 100 Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 5.0
Phytopresom Cera-236 (Nippon Fine Chemical Co., Ltd.) 0.5
2-Ethylhexyl hydroxystearate 3.0
(Polyglyceryl-2 isostearate / dimer dilinoleic acid) copolymer
1.0
Neopentyl glycol dicaprate 1.0
Candelilla Row 4.0
Rice wax 8.0
Polyethylene wax 2.0
Tribehenin 1.0
Sorbitan sesquiisostearate 2.0
Rosehip oil 0.1
VC Ethyl (Nippon Fine Chemical Co., Ltd.) 0.01
Tocopherol 0.1
Iron oxide 2.0
Titanium oxide 1.2
Mica 1.5
Red No. 202 0.1
Levan composition of Production Example 1 0.03
Purified water 2.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
After uniformly heating, stirring and mixing all the components, the mixture was filled in a mold and rapidly cooled.

(Example 34)
lipstick
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
LUSPLAN SR-DP4 (Nippon Fine Chemical Co., Ltd.) 7.0
Plandoll-S (Nippon Fine Chemical Co., Ltd.) 3.0
Hydrogenated polyisobutene 5.0
Trioctanoin 10.0
Tri (caprylic acid / capric acid) glyceryl Amount totaling 100 Dialkyl carbonate (C14, 15) 3.0
Dextrin palmitate 0.9
Stearoyl Lactate Na 0.9
Cetyl octanoate 24.0
Dimethicone 5.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 2.0
Celesin 8.5
Candelilla Row 4.0
Sorbitan sesquioleate 0.15
Hydrogen Dimethicone 2.0
Ethanol 0.1
Tocopherol 0.5
Nylon-12 2.0
(Ethylene / Propylene) Copolymer 0.5
Sulfate Ba 1.0
Iron oxide 2.0
Levan composition of Production Example 1 0.05
Mica 2.0
Titanium oxide 1.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
After uniformly heating, stirring and mixing all the components, the mixture was filled in a mold and rapidly cooled.

(Example 35)
Water-containing gloss
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Octyldodecanol 27.0
Ethyl cellulose 2.5
Triethylhexanoin (IOTG: Nippon Fine Chemical Co., Ltd.) 3.0
LUSPLAN PI-DA (Nippon Fine Chemical Co., Ltd.) 2.0
LUSPLAN DD-DHR (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 0.1
Dimethylsilylated silica 0.2
Inulin stearate 0.3
PEG-60 hydrogenated castor oil 1.0
Red No. 202 Appropriate amount Yellow No. 4 Appropriate amount Titanium oxide Appropriate amount Sorbitan stearate, coconut fatty acid sucrose mixture (ALACEL2121 manufactured by Croda Co., Ltd.) 3.0
Part B Glycerin 7.0
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.4
Maltose 2.0
Levan composition of Production Example 1 0.05
Phenoxyethanol 0.2
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
A part and B part were each heated and melted to make them uniform, and B part was mixed with A part.

(Example 36)
mascara
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Iron Oxide (Black) 10.0
Levan composition of Production Example 1 0.1
Amount of purified water totaling 100 Part B Polyacrylic acid ester emulsion 30.0
Part C Light Isoparaffin 30.0
Solid paraffin 8.0
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 0.5
Sorbitan sesquioleate 4.0
Preservatives Appropriate amount Fragrance Appropriate amount -------------
(Preparation method)
After dispersing part A with a homomixer, part B was heated and mixed (aqueous phase). The components of Part C were heated and mixed, an aqueous phase was added to Part C, and the mixture was uniformly emulsified and dispersed with a homomixer.

(Example 37)
eye shadow
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A talc 10.0
Kaolin 2.0
Facial department 5.0
Part B Plandoll-H (Nippon Fine Chemical Co., Ltd.) 3.0
Stearic acid 3.0
Isopropyl myristate 5.0
Propylene glycol monolaurate 3.0
Tocopherol 0.05
Incense family 0.05
Part C BG 5.0
Glycerin 1.0
Levan composition of Production Example 1 0.2
Preservatives Appropriate amount Triethanolamine 1.2
EDTA-2Na 0.1
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was mixed with a blender and then treated with a crusher (powder part). Parts B and C were mixed and dissolved by heating. Part A was added to part C, and the mixture was stirred and mixed. Part B was added to this with stirring, dispersed by a homomixer, and stirred and cooled to room temperature to obtain the desired eye shadow.

(Example 38)
Liquid foundation
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Purified water Amount totaling 100 Carboxyvinyl polymer 0.1
Levan composition of Production Example 1 0.1
Potassium hydroxide Appropriate amount DPG 5.0
Preservative Appropriate amount B part Polyether modified silicone mixture 5.0
(BY22-008M manufactured by Toray Dow Corning Silicone Co., Ltd.)
Polyglyceryl isostearate-2 1.0
Trimethylsiloxysilicic acid 3.0
Phenylmethicone 1.0
Cyclomethicone 9.0
Part C Titanium oxide / iron oxide mixture 12.5
(FDP-C111S manufactured by Toiro Pigment Co., Ltd.)
Zinc oxide 10.0
Sericite 0.36
Titanium oxide 8.32
Iron oxide yellow 0.8
Iron oxide red 0.36
Iron oxide black 0.16
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
After heating and stirring Part A at 70 ° C., Part C was added for dispersion treatment. This was preheated to 70 ° C. and added to part B for emulsification and dispersion. Then it was cooled to room temperature.

(Example 39)
Liquid foundation
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Octilt Azone 1.5
Ethylhexyl methoxycinnamate 1.0
Quotanium-18 hectorite 0.5
Part B Cyclomethicone 25.0
Mica 6.0
Part C Glycerin 5.0
Levan composition of Production Example 1 0.5
Methylparaben 0.2
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was heated and dissolved, and part B was heated and uniformly dispersed in part A (part D). Part C is heated and dissolved, part C is added to part D with stirring, emulsified, and then cooled to about 40 ° C.

(Example 40)
Foundation
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A isododecane 10.0
Tri (caprylic acid / capric acid) glyceryl (Nippon Fine Chemical Co., Ltd.) 4.0
Ethylhexyl methoxycinnamate 3.0
Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-LG4 (Nippon Fine Chemical Co., Ltd.) 1.0
Vaseline 1.0
Isotridecyl isononanoate 2.0
Ascorbic Tetrahexyl Decanoate 0.1
Dextrin palmitate 0.3
Sorbitan isostearate 1.5
Tribehenin 0.5
(Butyl acrylate / glycol dimethacrylate) Crosspolymer,
Silica, (Methyl Methacrylate / Glycol Dimethacrylate)
Crosspolymer mixture 2.0
Boron Nitride 1.0
Polysorbate 20 2.0
PEG-60 hydrogenated castor oil 1.0
Gistear dimonium hectorite (20%) 2.5
Polypropylsilsesquioxane cyclopentasiloxane mixture 1.0
Mica 15.0
Talc 4.0
Zinc oxide 5.0
Titanium oxide 10.0
Iron oxide 1.5
Part B Water Total amount of 100 DPG 4.0
Levan composition of Production Example 1 0.1
Maltitol (75% solution) 1.0
Neosolue-Aqua (Nippon Fine Chemical Co., Ltd.) 0.4
Na chloride 1.0
BG 1.0
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Ethanol 0.5
Phenoxyethanol 0.3
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A was heated to about 70 ° C., stirred well and dispersed uniformly. Part B was heated to about 70 ° C. to make it uniform, and then part B was added to part A, stirred and emulsified at about 70 ° C., and cooled to about 40 ° C.

(Example 41)
Base cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A LUSPLAN DD-DA7 (Nippon Fine Chemical Co., Ltd.) 5.0
Argania spinosa kernel oil 0.1
Cyclomethicone 14.0
Trimethylsiloxysilicic acid 3.0
Glyceryl stearate (SE) 2.0
Stearic acid PG (SE) 2.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 0.5
Stearic acid 0.5
Palmitic acid 0.5
Ethylhexyl methoxycinnamate 0.5
Tocopherol 0.2
Part B BG 10.0
Ethanol 1.0
Mica 8.0
Talc 7.0
Phenoxyethanol 0.8
Hydrogenated lecithin 0.1
Levan composition of Production Example 1 0.1
Titanate (Li / cobalt) 0.2
Amount of purified water totaling 100 Part C Dextrin (1%) 1.0
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Xanthan gum (10%) 1.0
Cellulose gum (10%) 1.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Parts A and B were heated and dissolved in separate containers. Part B was added to part A and emulsified, then part C was added and mixed uniformly. After stirring, the mixture was cooled to 40 ° C.

(Example 42)
Sunscreen cosmetics
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Quotanium-18 Hectorite 1.0
Part B Cyclomethicone 13.7
Diphenyldimethicone 2.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 0.5
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 2.0
Dicaprilyl Carbonate 1.0
Dimethicone Copolyol 5.5
Part C Silicone treated fine particles Titanium oxide 3.9
Silicone treated zinc oxide 2.1
Part D Stearic acid Al 0.7
Al 0.5 hydroxide
Isononyl isononanoate 2.5
Isodecyl neopentane (Nippon Fine Chemical Co., Ltd.) 1.5
Neosolue-MP (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-DE (Nippon Fine Chemical Co., Ltd.) 1.0
Part E trimethylsiloxysilicic acid 1.2
Stearyl glycyrrhetinate 0.02
Sorbitan sesquioleate 2.0
Tocopherol 0.02
Part F Na chloride 1.0
Levan composition of Production Example 1 0.1
Methylparaben 0.15
Amount of purified water totaling 100 -------------
(Preparation method)
Add part A to part B and stir. Further C is added and dispersed using a roller mill. The D part is heated and melted, added to the mixture of A, B, and C parts, and the E part is further added to bring the temperature to about 70 ° C. Part F is warmed and gradually emulsified with stirring in the mixture of parts A to E. Cool with stirring, stop stirring at 40-35 ° C, and leave.

(Example 43)
Sunscreen cosmetics
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ultrafine Titanium Oxide 5.0
Amount of purified water totaling 100 BG 7.0
Hydrogenated lecithin 0.1
Levan composition of Production Example 1 0.1
Disodium edetate 0.05
Triethanolamine 1.0
Part B Oxybenzone 3.0
Octyl paramethoxycinnamate 5.0
t-Butylmethoxybenzoylmethane 3.0
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 8.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 2.0
YOFCO MAS (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG3 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG4 (Nippon Fine Chemical Co., Ltd.) 0.1
LUSPLAN PI-DA (Nippon Fine Chemical Co., Ltd.) 3.0
Cetyl ethylcaproate (NS-CIO: Nippon Fine Chemical Co., Ltd.) 3.0
Isopropyl sebacate (Nippon Fine Chemical Co., Ltd.) 5.0
Stearyl alcohol 3.0
Bacil alcohol 1.0
Stearic acid 3.0
Glyceryl monostearate 3.0
Ethyl acrylate 1.0
Antioxidants, preservatives, fragrances Appropriate amount -------------
(Preparation method)
Part A is heated and dissolved to sufficiently disperse it. A portion B which had been heated and dissolved was added thereto, and the mixture was emulsified and dispersed using a homogenizer, and the mixture was stirred and cooled to room temperature.

(Example 44)
Sunscreen cosmetics
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
BG 10.0
Glycerin 9.0
Levan composition of Production Example 1 0.05
Part B Octocrylene 4.0
Octyl salicylate 4.0
Diethylaminohydroxybenzoyl hexyl benzoate 2.25
t-Butylmethoxydibenzoylmethane 1.0
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 3.0
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical Co., Ltd.) 2.0
Isopropyl sebacate (Nippon Fine Chemical Co., Ltd.) 1.0
Behenyl alcohol 2.0
Cetearyl alcohol 2.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Tocopherol 0.05
Part C Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Methylparaben Appropriate amount Water Amount that totals 100 Part D Carbomer (2%) 5.0
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 10.0
Water-dispersed titanium oxide 5.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Disperse part A evenly. Parts B and C are each heated and dissolved at about 70 ° C. After gradually adding the B part to the A part, the C part is gradually added and emulsified. Cool while stirring, add part D at 45 ° C, and stir.

(Example 45)
Sunscreen cosmetics
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Silicone treated zinc oxide 8.0
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 3.0
Diethylaminohydroxybenzoyl hexyl benzoate 5.0
Ethylhexyl methoxycinnamate 5.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 0.1
YOFCO MAC (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG3 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG4 (Nippon Fine Chemical Co., Ltd.) 0.1
LUSPLAN PI-DA (Nippon Fine Chemical Co., Ltd.) 0.1
Cetyl ethylcaproate (NS-CIO: Nippon Fine Chemical Co., Ltd.) 0.1
Cyclopentasiloxane 5.0
Cetyl PEG / PPG-10 / 1 Dimethicone 2.0
PEG-9 Polydimethylsiloxyethyl Dimethicone 1.0
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical Co., Ltd.) 2.0
Neosolue-DE (Nippon Fine Chemical Co., Ltd.) 0.5
Organic modified clay mineral 2.0
(Benton 38 manufactured by National Head)
Part B Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 5.0
Glycerin 3.0
BG 9.0
Levan composition of Production Example 1 0.1
Phenoxyethanol 0.3
NaCl 0.04
VC Ethyl (Nippon Fine Chemical Co., Ltd.) 0.1
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and B are heated and dissolved to uniformly disperse. Part B is gradually added to part A to emulsify. Cool with stirring.

(Example 46)
cream
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Mineral oil 7.8
Vaseline 7.0
Squalene 0.2
Jojoba oil 0.15
Microcrystalline wax 2.4
Paraffin wax 2.0
Al 0.9 distearate
Hydrogenated polyisobutene 2.8
Lanolin alcohol (Ecolano AL-E: Nippon Fine Chemical Co., Ltd.) 2.3
Octyldodecanol 3.0
Part B Magnesium Sulfate 0.5
Na benzoate 0.1
Concentrated glycerin 3.5
Levan composition of Production Example 1 0.05
Amount of purified water totaling 100 Part C Mg stearate 0.9
Cyclomethicone 2.5
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Parts A and B are heated and dissolved to uniformly disperse. Part B is gradually added to part A to emulsify. The dispersed part C is blended and cooled with stirring.

(Example 47)
Moisturizing lotion
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Levan composition of Production Example 1 0.1
Glycolipid 0.2
Acetylglucosamine 0.2
Diglycerin 3.0
Hydrolyzed hyaluronic acid 0.01
Arginine 0.05
Part B purified water 20.0
Part C Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Betaine 0.5
Pullulan 0.5
Hyaluronic acid Na 0.01
Hydroxyethyl cellulose 0.03
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was mixed and slowly added to part B with stirring to prepare a nanovesicle solution. Further, it was added to the C part mixed in advance to obtain a uniform liquid.

(Example 48)
Moisturizing lotion
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Levan Composition of Production Example 1 0.2
Hydrogenated lecithin (PC90%) 1.0
Glycolipid 0.3
Astaxanthin 0.01
Ubiquinone 0.05
Part B purified water 20.0
Part C PEG / PPG / Polybutylene Glycol-8 / 5/3 Glycerin 0.5
Glucosyl ceramide 0.5
Glucosylrutin 0.01
Polyquaternium-51 0.5
Acetyl Hexapeptide-8 0.001
Hydrolyzed collagen 0.05
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was mixed and part B was added slowly with stirring to prepare a nanovesicle solution. Further, it was added to the C part mixed in advance to obtain a uniform liquid.

(Example 49)
Gel
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Levan composition of Production Example 1 0.1
Hydrogenated lecithin (PC70%) 0.5
Phosphatidylinositol 0.1
BG 2.0
Glucosamine 0.1
Glycerin 3.0
Purified water 30.0
Part B PEG-4000 0.2
Methylgluces-10 1.0
Phenoxyethanol 0.3
Pyridoxine hydrochloride 0.05
Atractylodes extract 0.1
Water-soluble proteoglycan 0.03
Ethylhexyl glycerin 0.2
Hydroxyethyl cellulose 0.05
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.01
Hydrolyzed collagen 0.01
Amount of purified water totaling 100 parts C
(Dimethyltaurine ammonium acrylate / vinylpyrrolidone) Copolymer 0.05
(Acrylate / Alkyl Acrylate (C10-30)) Cross Polymer 0.10
Arginine 0.25
Purified water 30.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A was stirred with a propeller to prepare a nanovesicle solution. Part C was made into a viscous liquid when mixed. Part B was mixed to obtain a uniform liquid. A part and B part were added to C part to make them uniform.

(Example 50)
Two-phase separation serum
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Neosolue-MCT (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 0.2
Squalene 0.5
Olive oil 2.0
Tocopherol acetate 3.0
Part B Neosolue-AquaS 0.3
Tremoist-SL 2.0
Levan composition of Production Example 1 0.3
Phenoxyethanol 0.3
Pyridoxine hydrochloride 0.05
Ethylhexyl glycerin 0.2
Methylparaben 0.1
NaCl 0.2
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and B were mixed to obtain a uniform liquid. Further, the two phases were mixed to prepare a two-phase separated preparation.

In the above formulation, the details of the ingredients described by the product names are as follows.
〇Plandol-H: Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
〇Plandol-S: Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
〇Plandol-G: Dimer dilinoleyl bis (behenyl / isostearyl / phytosteryl)
〇Plandol-DP: Bisdiglyceryl polyacyl adipate-2
〇Plandol-ISS: Phytosteryl isostearate 〇Plandol-SUN: Sunflower seed oil fatty acid phytosteryl 〇Plandol-MAS: Macadamia nut oil fatty acid phytosteryl 〇Plandol-LG1: Di (phytosteryl / octyldodecyl) lauroyl glutamate
〇Plandol-LG2: Di lauroyl glutamate (phytosteryl / octyldodecyl)
〇Plandol-LG3: Di-lauroyl glutamate (phytosteryl / octyldodecyl / behenyl)
〇Plandol-LG4: Di-lauroyl glutamate (phytosteryl / octyldodecyl / behenyl)
〇LUS PLAN DD-IS: Dimersylinoleyl diisostearate 〇LUSPLAN PI-DA: Dimergelinoleate di (isostearyl / phytosteryl)
〇LUSPLAN DD-DHR: Dimerge linoleic acid hydrogenated rosin condensate 〇LUSPLAN DD-DA5: Dimergelinoleic acid Dimergelinoleil 〇LUSPLAN DD-DA7: Dimergelinoleic acid Dimergelinoleil 〇LUSPLAN SR-DM4: Die Dimer dilinoleic acid dimer dilinoleic acid, tri (caprylic acid / capric acid) glyceryl 〇LUS PLAN SR-DP4: dimer dilinoleic acid dimer dilinoleic acid, pentaerythrityl tetraisostearate 〇 Neosolue-Aquilio: bisethoxydiglycol cyclohexanedicarboxylic acid 〇 Neosolue-Aqua: (eicosane linoleic acid / tetradecanedioic acid) polyglyceryl-10, glycerin 〇 Neosolue-Aqua S: (eicosane linoleic acid / tetradecanedioic acid) polyglyceryl-10, glycerin 〇 Neosolue-MP: dineopentane methylpentanediol 〇 -DE: Diethylpentanediol dineopentanoate 〇 Neosolue-MCT: Tri (caprylic acid / capric acid) glyceryl 〇 Phytocompo-PP: Hydrogenated lecithin, phytosterols 〇 Phytocompo-C: Hydrophobic lecithin, phytosterols, ceramide 2, ceramide 3 , Ceramide 6II
〇 Phytocompo-SP: hydrogenated lecithin, phytosterols, BG, glycerin Phytopresom Cera-236: hydrogenated lecithin, soybean sterol, ceramide 2, ceramide 3, ceramide 6II
〇 Tremoist-TP: Snow fungus polysaccharide 〇 Tremoist-SL: Snow fungus polysaccharide aqueous solution (1%)
〇YOFCO MAC: Macadamia nut oil fatty acid cholesteryl

Claims (2)

Contains levan composition ,
The levan composition is a hyaluronic acid production promoter containing 95% by mass or more of levan having an average degree of polymerization of 10 to 21 and a degree of polymerization of 5 to 60 in 100% by mass of total levan. A cosmetic containing the hyaluronic acid production promoter according to claim 1.