JP2019202963A - Tranexamic acid-containing cosmetic or skin external preparation - Google Patents

Abstract

To provide cosmetics or skin external preparations in which coloring with heat or time is suppressed, in cosmetics or skin external preparations containing tranexamic acid or a derivative thereof or a salt thereof and a reducing sugar.SOLUTION: A cosmetic or skin external preparation containing the following components (A) to (C) as essential components is used. The cosmetic or skin external preparation of the present invention can reduce the concern of coloring when tranexamic acid and reducing sugar are used in combination. (A) Tranexamic acid or a derivative thereof or a salt thereof. (B) Reducing sugar or derivatives thereof. (C) Acidic component.SELECTED DRAWING: None

Description

  The present invention relates to a cosmetic or skin external preparation containing (A) tranexamic acid or a derivative thereof or a salt thereof, (B) a reducing sugar or a derivative thereof, and (C) an acidic component.

  Tranexamic acid has a hemostatic action and an anti-inflammatory action, so that it is used as an active ingredient of pharmaceuticals, and has a rough skin improving action and a whitening action, and thus is widely used in cosmetics and skin external preparations. Saccharides are components that are widely used in cosmetics and external preparations for the purpose of moisturizing, moistening, and skin conditioning. However, when tranexamic acid and a saccharide, particularly a saccharide having a reducing end (reducing sugar) are used in combination, there is a problem that coloring occurs due to heat or time.

  As a solution to the above problem, for example, Patent Document 1 discloses a composition containing tranexamic acids and saccharides, inorganic acids or salts thereof, organic acids or salts thereof, alcohols, vitamins or derivatives thereof, A cosmetic composition containing a chelating agent and one or more selected from plant, seaweed or animal-derived components is disclosed. Patent Document 2 discloses acyls such as tranexamic acid, sugars and N-caproylglycine. An external preparation containing an amino acid is disclosed, but it is not always sufficient.

JP 2014-62077 A Japanese Unexamined Patent Publication No. 2016-27037

  The problem to be solved by the present invention is to provide a cosmetic or skin external preparation containing tranexamic acid or a derivative thereof or a salt thereof and a reducing sugar, in which coloring due to heat or aging is suppressed. There is.

  As a result of intensive studies to solve the above problems, the present inventors have used (A) tranexamic acid or a derivative thereof or a salt thereof, (B) a reducing sugar or a derivative thereof, and (C) an acidic component in combination. As a result, it was found that coloring due to heat or time was suppressed, and the present invention was completed.

  The cosmetic or external preparation for skin of the present invention is sufficiently suppressed in coloring due to heat or time, and can reduce the concern about coloring when tranexamic acid and reducing sugar are used in combination.

The cosmetic or external preparation for skin of the present invention contains the following components (A) to (C) as essential components.
(A) tranexamic acid or a derivative thereof or a salt thereof (B) a reducing sugar or a derivative thereof (C) an acidic component

  The tranexamic acid of component (A) or a derivative thereof or a salt thereof used in the cosmetic or external preparation for skin of the present invention will be described. Tranexamic acid is also called trans-4-aminomethylcyclohexane-1-carboxylic acid, It is a compound having both an amino group and a carboxyl group in the molecule. The tranexamic acid used for this invention may be mix | blended with the form as it is, or may be mix | blended with the form of a salt. The component (A) may be a tranexamic acid derivative, and specific examples include ester derivatives such as tranexamic acid cetyl ester; amide derivatives such as tranexamic acid methylamide. The blending amount of the component (A) of the present invention into the cosmetic or external preparation for skin may be blended to such an extent that the intended effect and efficacy of the component (A) can be exhibited, and is not particularly limited. About 0.001 to 10% by weight, preferably about 0.01 to 5% by weight can be blended.

  The reducing sugar or derivative thereof of component (B) used in the cosmetic or skin external preparation of the present invention is not particularly limited as long as it is a saccharide having a reducing end or a derivative thereof. Specifically, examples of the reducing sugar include glucose, fructose, mannose, galactose, xylose, fucose, arabinose, lactose, maltose, cellobiose and the like. Examples of reducing sugar derivatives include glycosides using reducing sugars as glycones and acylated reducing sugars. These may be used alone or in combination of two or more. The blending amount of the component (B) of the present invention into the cosmetic or external preparation for skin may be blended to such an extent that the intended effect and efficacy of the component (B) can be exhibited, and is not particularly limited. About 0.001 to 20% by weight, more preferably about 0.01 to 10% by weight can be blended.

  Specific examples of the acidic component (C) used in the cosmetic or external preparation for skin of the present invention include phosphoric acid, phosphorous acid, pyrophosphoric acid, metaphosphoric acid, hypophosphorous acid, sulfuric acid, sulfurous acid, pyro Inorganic acids such as sulfurous acid and hydrochloric acid and their esters; acetic acid, butyric acid, propionic acid, sorbic acid, glycolic acid, lactic acid, citric acid, malic acid, gluconic acid and its dehydrated gluconolactone, tartaric acid, oxalic acid, Malonic acid, succinic acid, fumaric acid, maleic acid, glutaric acid, adipic acid, phytic acid, etidronic acid, edetic acid, pentetic acid, hydroxyethylethylenediaminetriacetic acid, benzoic acid, phthalic acid, gallic acid, cinnamic acid, salicylic acid , Organic acids such as glutamic acid and aspartic acid; polyacrylic acid, polymethacrylic acid, alkyl methacrylate methacrylate copolymer, cal Carboxyvinyl polymers, carboxymethyl cellulose, hyaluronic acid, carrageenan, pectin, gum arabic, xanthan gum, gellan gum, agar, include acidic polymer compounds such white fungus polysaccharides body. These acidic components may be in the form of a salt with an organic base such as arginine, histidine or guanidine. These may be used alone or in combination of two or more. Of these, phosphoric acid, pyrosulfurous acid, hydrochloric acid, citric acid, phytic acid, malic acid, succinic acid, fumaric acid, gluconolactone, etidronic acid, edetic acid, pentetic acid, salicylic acid, glutamic acid, aspartic acid, polyacrylic acid Polymethacrylic acid, alkyl methacrylate acrylic acid copolymer, carboxyvinyl polymer and the like are preferable.

  Coloring caused by the combination of tranexamic acid and reducing sugar is considered to be a kind of browning phenomenon generally called Maillard reaction. Maillard reaction is a general term for reaction mechanisms in which reducing sugars and compounds having amino groups (amino acids, peptides, proteins, etc.) generate brown substances (melanoidins) by heating or the like. In the present invention, the acidic component of component (C) suppresses coloring of tranexamic acid and reducing sugar because the amino group of tranexamic acid and the acidic component become a salt by neutralization reaction, protect the amino group, and reduce the amino group. This is thought to suppress the attack on sugar. From such a viewpoint, in the cosmetic or skin external preparation of the present invention, the amount of component (C) is 0.1 to 10 equivalents, preferably 0.2 to 5 with respect to 1 equivalent of the amino group of tranexamic acid. It is good to mix | blend in the range of an equivalent.

  In the cosmetic or skin external preparation of the present invention, an inorganic base such as sodium hydroxide, potassium hydroxide, or calcium hydroxide may reduce the effects of the present invention. The reason is that such an inorganic base is more basic than the amino group of tranexamic acid, so that the acidic component of the blended component (C) forms a salt preferentially with the inorganic base over the amino group. This is because the aforementioned amino group protecting effect is not exhibited. Therefore, in the cosmetic or skin external preparation of the present invention, the inorganic base is preferably contained in a base equivalent less than the acid equivalent of the component (C), specifically, 1 equivalent of the component (C). On the other hand, it is desirable that the inorganic base is contained in an amount of 0.5 equivalent or less, preferably 0.2 equivalent or less, more preferably 0.1 equivalent or less. In addition, about the basic organic base component weaker than an amino group, there is no restriction | limiting in particular in the compounding quantity. From such a point of view, the pH of the cosmetic or external preparation for skin of the present invention is preferably on the acidic side. Specifically, the pH is 3 to 7, preferably 3.5 to 6.5. It is good to be.

  In addition to the essential ingredients of the present invention, the cosmetic preparation of the present invention contains, in addition to the essential ingredients of the present invention, water and additives that are usually incorporated into cosmetics, such as oil bases, surfactants, alcohols, and humectants. , Polymer / thickening / gelling agent, antioxidant, preservative, bactericidal agent, chelating agent, pH adjuster / acid / alkali, UV absorber, whitening agent, solvent, exfoliating / dissolving agent, antipruritic agent, Anti-inflammatory agent, antiperspirant, refreshing agent, antihistamine, astringent, stimulant, hair-growth agent / blood circulation promoter, reducing agent / oxidant, polymer powder, hydroxy acid, vitamins and derivatives thereof, saccharides and the like Derivatives, organic acids, enzymes, nucleic acids, hormones, inorganic powders, fragrances, pigments and the like can be blended.

  Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as cannic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Hydrocarbons such as paraffin; candelilla wax, carnauba wax, rice wax, wax wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Waxes such as Tropsch wax, polyethylene wax, ethylene propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cacao butter, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Fats and oils; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof, phospholipids such as lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospho Phospholipid derivatives such as lipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; sapogenins; saponins; cholesteryl acetate, nonanoic acid Lesteryl, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamate di (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl- Acyl sarcosine alkyl esters such as L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N-lauroylsarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid Cholesteryl, macadamia nut oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, isostearic acid phytosteryl, soft lano Sterol esters such as phosphofatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid / cholesterol complex, phospholipid / phytosterol complex; octyl myristate Dodecyl, hexyldecyl myristate, octyldodecyl isostearate, cetyl parimitate, octyldodecyl palmitate, cetyl octoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isopentyl neopentanoate, Isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyl oleate Dodecyl, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, ethyl avocado oil, isopropyl myristate, isopropyl palmitate, palmitate Octyl acid, isopropyl isostearate, lanolin fatty acid isopropyl, methyl heptyl laurate, methyl heptyl myristate, methyl heptyl palmitate, methyl heptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyl sebacate Octyl, diisobutyl adipate, dioctyl adipate, dioctyl succinate, citric acid Monoalcohol carboxylates such as triethyl; oxyacid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, γ-ercalactone; glyceryl trioctanoate, glyceryl trioleate, triisostearic acid Glyceryl, glyceryl diisostearate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), Glyceryl behenate, glyceryl trioctanoate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol octanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, (isostearic acid / sebacic acid) Ditrimethylolpropane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / rosin acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid / ricinolein) Acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethyl distearate) Lenglycol), polymethyl alcohol fatty acid esters such as 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate; alkyl ethers such as dicaprylyl ether; Diisopropyl merlinoleate, diisostearyl dimerlinoleate, dimerisolinoleate di (isostearyl / phytosteryl), dimerlinoleic acid (phytosteryl / behenyl), dimerlinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) ), Dimer dilinoleic acid dimer dilinoleyl, diisostearic acid dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl dimer dilinole Dimer acid or dimer diol derivative such as ruether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA) , Fatty acid alkanolamides such as lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); Polysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclope) Tasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, aminopropyldimethicone and aminomodified silicone such as amodimethicone, cation Polyether modified silicone such as modified silicone and dimethicone copolyol, polyglycerin modified silicone, sugar modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid Modified silicone, peptide modified silicone, fluorine modified silicone, cation modified and polyether modified silicone Silicones such as corn, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, polysiloxane-oxyalkylene copolymers; Fluorine-based oils such as perfluorooctane and perfluoropolyether are preferred.

  As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosane diacid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan Sulfuric acid; white jellyfish extract; white jellyfish polysaccharide; fructans such as inulin and levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; organic acids such as citric acid, tartaric acid and lactic acid and salts thereof; urea; 2-pyrrolidone-5 -Carboxylic acid and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine Amino acids and salts thereof such as glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine; collagen, fish collagen, atelocollagen, gelatin, elastin, collagen degrading peptide, Hydrolyzed collagen, Hydroxypropylammonium chloride hydrolyzed collagen, Elastin degrading peptide, Keratin degrading peptide, Hydrolyzed keratin, Conchiolin degrading peptide, Hydrolyzed conchiolin, Silk proteolytic peptide, Hydrolyzed silk, Lauroyl hydrolyzed silk sodium, Soy protein Peptides, wheat proteolytic peptides, hydrolyzed wheat proteins, casein degrading peptides, acylated peptides and other protein peptides and their Derivatives; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, Glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract Animal / plant extract components such as eucalyptus extract and merirot extract, natural ceramide (type 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide and sugar ceramide-containing extract Ceramides can be mentioned as preferred.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium phosphate, cocoyl glutamate triethanolamine, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine, lysine Na dilauroyl glutamate; sodium laureth acetate, etc. Polyoxyethylene alkyl ether acetates; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; Fatty acid glyceride sulfate such as coconut oil fatty acid sodium glycerin sulfate; Oxyethylene sulfate; Olefin sulfonate such as sodium α-olefin sulfonate; Alkyl sulfosuccinate such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; Disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate Alkyl ether sulfosuccinates such as sodium acid, sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonate; alkanesulfonate; α-sulfo fatty acid methyl ester salt; acyl isethionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetates; alkyl ether phosphates such as sodium laureth phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate esters such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphorus Acid salts; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof; Nonionic surfactants such as ionic surfactants, laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steale Various polyoxyethylene addition numbers such as bis (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether), octyldecesses (polyoxyethylene octyldodecyl ether) Polyoxyethylene alkyl ethers; polyoxyethylene alkyl phenyl ethers; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, Castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid; poly Polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether; Polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol ; (Poly) glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; Glycerol such as lysyl, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut fatty acid, mono cottonseed oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-pyroglutarate oleate Fatty acid partial esters; stearic acid polyglyceryl-2, 3, 4, 5, 6, 8, 10, distearate polyglyceryl-6, 10, stearate polyglyceryl-2, decastearic acid polyglyceryl- 10, polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 8, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 10, triisostearate polyglyceryl -2, tetraglycostyl tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 8, dioleate polyglyceryl-6, trioleic acid Polyglyceryl fatty acid esters such as polyglyceryl-2 and dekaleate polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol moiety Fatty acid ester; Maltitol partial fatty acid ester; Maltitol ether; Sorbitan monooleate, Sorbitan monoisostearate, Sorbitan monolaurate, Sorbi Sorbitan fatty acid esters such as dimonopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl Sugar derivative partial esters such as glucoside fatty acid esters and undecylenic acid trehalose; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; glycolipids such as mannosyl erythritol lipids; lanolin alcohol; reduced lanolin; polyoxyethylene distearate; Polyoxyethylene fatty acid mono and di such as diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate Polyoxyethylene / propylene glycol fatty acid ester; polyoxyethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol such as polyoxyethylene monooleate Fatty acid ester; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate such as polyoxyethylene sorbitan monooleate; polyoxyethylene sorbitan monolaurate; Polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxy Polyoxyethylene sorbitol fatty acid ester such as ethylene sorbitol monostearate; Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; Isostearyl glyceryl ether, Kimi Alkyl glyceryl ethers such as alcohol, ceralkyl alcohol and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural systems such as saponins Surfactant; polyoxyethylene fatty acid amide; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil Fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid Fatty acid alkanolamides such as diethanolamide (partamide DEA) and coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethyl Amine oxide; Polyoxyethylene alkyl mercaptan; Polyether-modified silicone such as dimethicone copolyol, polysiloxane o Silicone nonionic surfactants such as xylalkylene copolymers, polyglycerin-modified silicones and sugar-modified silicones; for cationic surfactants, behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltri Alkyltrimethylammonium chloride such as monium chloride; Alkyltrimethylammonium bromide such as stearyltrimonium bromide; Dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; Fatty acids such as stearamidepropyldimethylamine and stearamideethyldiethylamine Amidoamine and its salt; alkyl ether amine such as stearoxypropyldimethylamine and its salt or quaternary salt; ethyl sulfate long chain Fatty acid amide type quaternary ammonium salts such as fatty acid (12-31) aminopropylethyldimethylammonium and ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamine and salts or quaternary salts thereof; alkylamine salt; fatty acid amide Guanidinium salt; alkyl etheraminemonium salt; alkyltrialkylene glycol ammonium salt; benzalkonium salt; benzethonium salt; pyridinium salt such as cetylpyridinium chloride; imidazolinium salt; alkylisoquinolinium salt; Salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyl dimethicone and amodimethicone; cation-modified silicones; cation-modified and polyether-modified silicones; Silicone-based cationic surfactants such as non-modified and polyether-modified silicones; in amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); cocamide Fatty acid amide alkyl-N, N-dimethylamino acid betaines such as propylbetaine and lauramidopropylbetaine; imidazoline type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; alkyldimethylaminoethanol sulfates Sulfate betaine; phosphate betaine such as alkyldimethylaminoethanol phosphate; phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingom Sphingophospholipids such as Erin, Lysolecithin, Hydrogenated soybean phospholipid, Partially hydrogenated soybean phospholipid, Hydrogenated egg yolk phospholipid, Partially hydrogenated egg yolk phospholipid, Phospholipids such as hydroxylated lecithin; Silicone amphoteric surfactant In the polymer surfactant, polyvinyl alcohol, sodium alginate, starch derivative, tragacanth gum, acrylic acid / methacrylic acid alkyl copolymer, and various silicone surfactants are preferable.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationic cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazoline derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzoyl chloride Luconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol , Photosensitizers, antibacterial zeolite, and silver ion are preferable, but when used as an antibacterial agent or antiseptic agent for antiseptic purposes, phenoxyethanol; 1 from the viewpoint of safety of cosmetics or skin external preparations; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.

  Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium oxide, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferred. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates, and magnesium phosphates are preferable.

  Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid-based UV absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone purple 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphsulfone Preference is given to acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

  Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

  Plant / animal / microbe extracts include iris extract, ashitaba extract, asunaro extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Chinchilla extract, fennel extract, turmeric extract, oolong tea extract, walnut extract, ages extract, pear leaf extract, enmeo extract, urgonum extract, duckweed extract, laurel extract, barley extract, ginseng extract, hypericum extract, licorice extract, onionis extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peony extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, Natto Extract, Carrot Extract, Garlic Extract, Novara Extract, Hibiscus Extract, Bacmond Extract, Lotus Extract, Parsley Extract, Birch Extract, Honey, Hamamelis Extract, Parietalia Extract, Hyacinth Extract, Bisabolol, Hinoki Extract, Bifidobacterium Extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, citrus extract, sorghum extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damacenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.

  As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 3, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1, red 105-1, red 106, red 2, red 3, red 201, red 202, red 203, red 204, red 205, red 206, red 207 , Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 28, red 230-1, red 230-2, red 231, red 232, red 3, red 401, red 404, red 405, red 501, red 502, red 503 Red 504, red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202-1, yellow 202-2, yellow 203, yellow 204, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, Yellow 406, Yellow 407, Yellow 5 and other legal dyes; Acid Red 14 and other acidic dyes; Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow and other basic dyes; HC Yellow 2 Nitro dyes such as HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26, etc. Dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (Bengara) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and loess Pigments; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; ultramarine and bitumen Inorganic blue pigments: Titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, pearl pigments; aluminum powder, Metal powder pigments such as perpowder and gold; anthraquinones such as astaxanthin and alizarin; anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, naphthoquinones such as cochineal, shikonin, bixin, Natural pigments and dyes such as flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylene Oxidative dye intermediates and couplers such as diamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; auto-oxidizing dyes such as indoline; dihydroxyacetone is preferred And the like as the correct ones.

  Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  Examples of the cosmetic or skin external preparation of the present invention include skin external preparations such as hair cosmetics, skin cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and ointments. From the viewpoint of exerting the effects of the present invention, it can be preferably used particularly for hair cosmetics and skin cosmetics. The cosmetic of the present invention can be produced according to a usual method.

  The cosmetic or skin external preparation of the present invention will be described in further detail. Examples of hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, and rinse-integrated shampoos. Rinsing, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow, split hair coat , Hair oil, permanent wave agent, straight permanent agent, oxidative hair dye, hair bleach, hair color pretreatment, hair color after treatment, permanent pretreatment, permare Terpolymers treatments, hair manicure, and as hair growth agents are preferred.

  Skin cosmetics include lotions such as soft lotion, astringent lotion, cleansing lotion, multi-layer lotion; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, Nourishing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; Liposome cosmetics such as liposomal serum and liposome lotion; packs and masks such as peel-off pack, powder pack, washing pack, oil pack, cleansing mask; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing gel Facial cleansers such as oils, cleansing masks, powders and facial cleansers; cosmetic soaps, transparent soaps, medicated soaps, liquid soaps, shaving soaps, synthetic cosmetic soaps Soap can be mentioned as preferred.

  As makeup cosmetics, white powder, dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment are preferable. .

  Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.

  Body cosmetics include body shampoos and other body cleansers, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics, depigmenting agents, depilation / hair removal agents, bathing agents, insect repellents, etc. A repeller is preferred.

  Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

  As the dosage form of the cosmetic or external preparation for skin of the present invention, emulsification such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type, etc. Type cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, pastes Preferred examples include cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

  The following examples further illustrate the present invention in detail but are not to be construed to limit the scope of the invention.

The lotion which mix | blended each component applicable to the component (A) tranexamic acid, the component (B) maltose, and the component (C) with the composition of Tables 1-3 was produced (Examples 1-18). For comparison, a lotion containing no component (C) was prepared (Comparative Example 1). In addition, coloring was not recognized in any lotion immediately after preparation. These lotions were stored at 50 ° C. for 2 weeks, and the appearance after storage was visually observed to confirm the presence or absence of coloring. The degree of coloring was evaluated in the following five stages, and the results are shown in Tables 1 to 3.

++++ Slightly colored ++ Colored + ・ ・ ・ Slightly colored ± Slightly colored − ・ ・ ・ No coloring

  From the results of Tables 1 to 3, it was found that the skin lotion containing the component (C) was suppressed in coloring compared to the skin lotion not containing the component (C).

  The following cosmetics containing the components (A) to (C) of the present invention were prepared. All the obtained cosmetics were those in which coloring was suppressed.

Example 19

Component Blending amount (% by weight)
--------------------------------------
Part A Tranexamic acid 2.00
Phytic acid 0.30
Purified water 18.00
Part B Arbutin 4.00
3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 0.20
Part C Maltose 1.00
Dipropylene glycol 4.00
Absolute ethanol 5.00
Glycerin 5.00
Hyaluronic acid Na 0.20
Pyrosulfite 0.10
Phosphoric acid proper amount edetate di-Na 0.10
Phenoxyethanol 0.30
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and dissolved uniformly. Part C was mixed and heated to about 70 ° C. to dissolve uniformly. Part C was cooled to 40 ° C., and parts A and B were mixed and made uniform.

Example 20 Lotion

Component Blending amount (% by weight)
--------------------------------------
Part A 1,3-butylene glycol 4.00
Diglycerin 2.00
Glycerin 1.00
Methylparaben 0.10
Part B Tranexamic acid 2.00
Etidronic acid 0.10
Malic acid 0.10
Salicylic acid 0.10
Purified water 18.00
Part C Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolute-Aquilio: Nippon Seika) 0.50
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.20
Hyaluronic acid 0.10
Glucose 0.10
Fructose 0.10
Mannose 0.10
Edetic acid di-Na 0.10
Pyrosulfite Na 0.10
Phenoxyethanol 0.20
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A, part B and part C were taken and mixed uniformly. Part A and part B were added to part C to make it uniform.

Example 21 Latex

Component Blending amount (% by weight)
--------------------------------------
Part A Dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl /
Behenyl) (Plandool-H: Nippon Seika) 1.00
N-lauroylmethyl-L-glutamate di (phytosteryl behenyl
2-octyldodecyl) (Plandool-LG1: Nippon Seika) 0.50
Glyceryl tri-2-ethylhexanoate (IOTG: Nippon Seika) 0.50
Hydrogenated palm oil 1.00
Diethylhexyl succinate 0.50
Stearyl alcohol 0.50
Behenyl alcohol 0.80
Lipophilic glyceryl monostearate 0.60
Self-emulsifying propylene glycol stearate 0.40
Polyoxyethylene glyceryl isostearate 0.40
Diglyceryl triisostearate 0.60
Ethyl paraoxybenzoate 0.10
Part B Carboxyvinyl polymer 0.20
Purified water 10.00
Part C Xanthan gum 0.06
Purified water 10.00
Part D White Jellyfish Polysaccharide (Tremoist-SL: Nippon Seika) 5.00
Part E Tranexamic acid 2.00
Citric acid 0.20
Methyl paraoxybenzoate 0.10
Propylene glycol 2.00
3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 0.50
Glycerin 1.00
Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosol-Aquorio: Nippon Seika) 1.00
Edetic acid di-Na 0.10
Xylose 0.02
Fucose 0.02
Phenoxyethanol 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and heated to about 70 ° C. and dissolved uniformly. Part C was mixed and stirred to give a viscous liquid. Part E was mixed and dissolved uniformly. After adding E part to A part and stirring and emulsifying, it cooled and added B part, C part, and D part at about 50 degreeC, and it stirred and made it uniform.

Example 22 Gel

Component Blending amount (% by weight)
--------------------------------------
Part A ethanol 5.00
Ethyl hexyl methoxycinnamate 0.01
Polyglycerin-10 0.2
1,3-butylene glycol 6.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Part B Alkyl methacrylate alkyl copolymer 1.00
Carboxyvinyl polymer 0.20
Lactose 0.20
Maltose 0.20
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.20
Glutamic acid 0.20
Aspartic acid 0.20
Pentethic acid (diethylenetriaminepentaacetic acid) 0.06
Citric acid 0.05
Na citrate Appropriate amount Purified water Total amount to be 100 ------------------------------------- −
(Preparation method)
Part A was mixed and dissolved uniformly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part A and part C were added to part B and stirred to make uniform.

Example 23 Gel

Component Blending amount (% by weight)
--------------------------------------
Part A PEG-30 0.20
Dipropylene glycol 1.00
Ethanol 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Part B Carboxyvinyl polymer 0.20
Xanthan gum 0.20
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.20
Carboxymethylcellulose 0.80
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.15
Glutamic acid 0.10
Pentethic acid (diethylenetriaminepentaacetic acid) 0.10
Hydrolyzed collagen 0.05
Fructose 0.05
Mannose 0.05
Lactose 0.05
Lactic acid 0.05
Lactic acid Na appropriate amount Sulfurous acid Na 0.10
Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolute-Aquilio: Nippon Seika) 0.50
Betaine 0.20
Sorbitol 0.05
Trehalose 3.00
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and dissolved uniformly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part A and part B were added to part C and stirred to make uniform.

Example 24 Gel

Component Blending amount (% by weight)
--------------------------------------
Part A 1,3-BG 4.00
Glycerin 1.00
Hexylene glycol 1.00
Pentylene glycol 1.00
Hydrogenated lecithin, phytosterols, ceramide 2,
(Phytopresome-Cera2: Nippon Seika) 0.30
Part B (Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer
0.20
Gellan gum 0.05
Carboxymethylcellulose 0.50
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.05
Purified water 20.00
Part C Tranexamic acid 2.00
3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 0.20
Olive leaf extract 0.05
Maronier extract 0.05
Glycosyl trehalose 0.05
Arbutin 0.20
Phytic acid 0.20
Glutamic acid 0.20
Succinic acid 0.10
Fumaric acid 0.05
Sodium fumarate appropriate amount HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.15
Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolute-Aquilio: Nippon Seika) 0.50
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. Part C was added to part A, stirred with a homomixer, uniformly dissolved, cooled, and part B was added at about 50 ° C. to make it uniform.

Example 25 Latex

Component Blending amount (% by weight)
--------------------------------------
Part A Setanol 0.20
Squalane 0.05
Jojoba oil 0.05
Diethylhexyl succinate 0.20
Polyglyceryl isostearate-10 0.10
Behenez-30 0.05
Ethylhexyl methoxycinnamate 0.05
Tocopherol 0.05
Part B Carboxymethylcellulose 0.20
Xanthan gum 0.20
Hyaluronic acid 0.03
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.20
Chondroitin sulfate Na 0.20
HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.01
Sorbitol 3.00
Succinic acid 0.03
Sodium succinate appropriate amount diglycerin 0.15
Maltose 0.20
Xylose 0.15
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. C part was added to A part, stirred and emulsified, then cooled and added at about 50 ° C., and B part was added and stirred to be uniform.

Example 26 Cream

Component Blending amount (% by weight)
--------------------------------------
Part A Batyl alcohol 2.00
Squalane 2.00
Glyceryl tri-2-ethylhexanoate 2.00
Diethylhexyl sebacate 2.00
Stearic acid 1.00
Macadamia nut oil fatty acid phytosteryl (Plandool-MAS: Nippon Seika) 1.00
Natural vitamin E 0.05
Behenyl alcohol 2.00
Lipophilic glyceryl monostearate1.00
Polyglyceryl oleate-10 0.10
Ethylparaben 0.15
Methyl polysiloxane 0.50
Polyoxyethylene cetyl ether 2.00
Hydrogenated lecithin, phytosterol complex (Phytocompo-PP: Nippon Seika) 1.00
Part B Carboxyvinyl polymer 0.20
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Gluconolactone 0.10
Succinic acid 0.01
Sodium succinate appropriate amount 1,3-butylene glycol 0.15
Glucose 0.20
Maltose 0.20
Fructose 0.20
Sohakuhi extract 0.20
Etidronic acid (60%) 0.10
(Eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
(Neosol-Aqua: Nippon Seika)
3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 0.20
Glycerin 0.20
Inositol 0.10
Methylparaben 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. C part was added to A part, stirred and emulsified, then cooled and added at about 50 ° C., and B part was added and stirred to be uniform.

Example 27 Cream

Component Blending amount (% by weight)
--------------------------------------
Part A jojoba oil 2.00
Dimerlinoleic acid (phytosteryl / isostearyl / cetyl / stearyl /
Behenyl) (Plandool-H: Nippon Seika) 1.00
Lauroyl glutamate (phytosteryl / octyldodecyl / behenyl)
(Plandool-LG3: Nippon Seika) 1.00
PEG-60 glyceryl isostearate 0.70
Polyglyceryl diisostearate-2 0.50
Macadamia nut oil fatty acid phytosteryl 1.00
Propylene glycol monostearate 0.60
Behenyl alcohol 1.20
Self-emulsifying glyceryl monostearate 1.20
Ethylparaben 0.15
Dimethicone 20cs 1.00
PEG-60 hydrogenated castor oil 0.30
Part B Carboxymethylcellulose 0.20
Carboxyvinyl polymer 0.20
(Acryloyldimethyltaurine / Beheneth-25 methacrylate) polymer
0.30
Purified water 20.00
Part C Tranexamic acid 2.00
3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 1.00
Arbutin 1.00
Ascorbyl glucoside 1.00
Phytic acid 0.05
Gluconic acid 0.05
Pyrosulfite 0.05
Citric acid 0.05
Sodium citrate appropriate amount dipotassium glycyrrhizinate 0.20
Ethylenediaminetetraacetic acid di-Na 0.10
1,3-butylene glycol 1.00
Glycerin 2.00
Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolute-Aquilio: Nippon Seika) 0.50
Methylparaben 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. C part was added to A part, stirred and emulsified, then cooled and added at about 50 ° C., and B part was added and stirred to be uniform.

Example 28 Emollient Cream

Component Blending amount (% by weight)
--------------------------------------
Part A Lauroyl glutamate di (phytosteryl / octyldodecyl)
(Plandool-LG2: Nippon Seika) 1.00
Dimer dilinoleic acid dimer dilinoleyl (LUSPLAN DD-DA7: Nippon Seika) 1.00
Liquid paraffin 2.50
Behenyl alcohol 2.00
Dimethicone (10cs) 1.50
Methylphenyl polysiloxane 0.50
Glyceryl laurate 1.50
Stearyl alcohol 1.20
Stearic acid PG (SE) 1.00
PEG-60 glyceryl isostearate 1.00
Ethyl hexyl methoxycinnamate 0.20
Ethylparaben 0.10
Part B Carboxymethylcellulose 0.30
Acrylic acid alkyl methacrylate copolymer 0.30
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.20
1,3-butylene glycol 6.00
Ethylenediamine disuccinic acid 3Na 0.30
Pentethic acid (diethylenetriaminepentaacetic acid) 0.05
Fumaric acid appropriate amount Fumarate Na appropriate amount Caprylyl glucoside 1.00
Ethyl glucoside 1.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. After adding C part to A part and emulsifying with a homomixer, it cooled and added B part at about 50 degreeC, and it stirred and made it uniform.

Example 29 Lotion

Component Blending amount (% by weight)
---------------------------------------
Part A Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6II
(Phytocompo-C: Nippon Seika) 0.30
1,2-pentanediol 3.00
Glycerin 6.00
Part B Tranexamic acid 2.00
Ascorbyl glucoside 0.50
3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 0.50
Phytic acid 0.30
Glutamic acid 0.20
Purified water 20.0
(Eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
(Neosol-Aqua: Nippon Seika)
BG 5.00
Tripropylene glycol 2.00
DPG 2.00
Maltose 1.00
Glucose 0.01
Phenoxyethanol 0.20
Methylparaben 0.15
Citric acid 0.10
Sodium citrate appropriate amount C part carboxyvinyl polymer 0.01
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part C was mixed to prepare a viscous liquid. Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 30 Latex

Component Blending amount (% by weight)
--------------------------------------
Part A sorbitan stearate 0.50
PEG-10 stearate 0.50
Polysorbate 60 0.50
Phytosteryl isostearate (Plandool-ISS: Nippon Seika) 1.00
Cetyl ethylhexanoate 3.70
Cetanol 1.20
Dimethicone (10cs) 1.00
Methylphenyl polysiloxane 0.50
1,2-hexanediol / caprylyl glycol 0.50
Ethylparaben 0.10
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.05
Stearoxyhydroxypropylmethylcellulose 0.10
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Edetic acid 0.02
Etidronic acid 0.02
Purified water 18.00
Part D 1,3-butylene glycol 3.00
(Eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
Maltose 1.00
Xylose 1.00
Lactose 1.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Citric acid 0.01
Na citrate 0.09
Xanthan gum 0.10
Carboxyvinyl polymer 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it was made uniform.

Example 31 Liquid Foundation

Component Blending amount (% by weight)
--------------------------------------
Part A Glyceryl stearate (SE) 1.00
Stearic acid PG (SE) 1.00
Lauroyl glutamate (phytosteryl / octyldodecyl)
(Plandool-LG2: Nippon Seika) 0.50
Cetyl octanoate 6.00
Diethylhexyl succinate 2.00
Tocopherol 0.10
Propylparaben 0.10
Titanium oxide / iron oxide mixture (FDP-W-007 manufactured by Toyo Pigment Co., Ltd.) 18.00
Mica 7.00
Octyl paramethoxycinnamate 5.00
Trimethylsiloxysilicate 3.00
Cyclomethicone 7.00
Phenylmethicone 5.00
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.20
Carboxymethylcellulose 0.05
(Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer
0.15
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Succinic acid 0.05
Sodium succinate appropriate amount Purified water 18.00
Part D (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
(Neosol-Aqua: Nippon Seika)
Xanthan gum 0.20
Etidronic acid 0.05
Glutamic acid diacetate 4Na 1.20
Maltose 1.00
1,3-butylene glycol 5.00
Pentylene glycol 3.00
Methylparaben 0.05
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it was made uniform.

Example 32 Moisturizing lotion

Component Blending amount (% by weight)
--------------------------------------
Part A (acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Carboxymethylcellulose Na 0.20
Purified water 20.00
Part B Tranexamic acid 2.00
Phytic acid 0.04
Etidronic acid 0.03
Purified water 18.00
Part C (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
(Neosol-Aqua: Nippon Seika)
1,3-butylene glycol 1.00
Glycerin 2.00
Citric acid 0.01
Sodium citrate appropriate amount ubiquinone 0.03
Glyceryl tri-2-ethylhexanoate (IOTG: Nippon Seika) 0.03
Tetraoleic acid Solves-60 0.12
PEG-60 hydrogenated castor oil 0.03
PEG-30 glyceryl isostearate 0.03
Methylparaben 0.20
Fragrance Trace Maltose 1.00
Caprylyl glucoside 1.00
Inulin 0.50
Ethanol 7.00
Triclosan 0.05
Glutamic acid diacetate 4Na 0.80
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and stirred to give a viscous liquid. Part B was mixed and dissolved uniformly. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. The mixture was cooled, and A and B parts were added to C part at about 50 ° C. and stirred to make it uniform.

Example 33 Deodorant Lotion

Component Blending amount (% by weight)
--------------------------------------
Part A Purified water Amount of total 100 (styrene / DVB) copolymer 0.20
Maltose 0.50
Lactose 0.50
Benzalkonium chloride 0.05
Na chloride 0.10
Carboxyvinyl polymer 0.02
Alkyl methacrylate methacrylate copolymer 0.10
(Eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
(Neosol-Aqua: Nippon Seika)
Glycerin 0.50
Hydrochloric acid 0.01
Sodium hydroxide appropriate amount Tranexamic acid 2.00
Etidronic acid 0.05
Phytic acid 1.00
Part B Ethanol 50.00
Methylparaben 0.20
--------------------------------------
(Preparation method)
Both part A and part B were dissolved at room temperature, and part B was gradually added to part A while stirring to make it uniform.

Example 34 Moisture Pack

Component Blending amount (% by weight)
--------------------------------------
Part A polyvinyl alcohol 13.00
Acryloyldimethyltaurine ammonium / VP) copolymer 0.80
Stearoxyhydroxypropylmethylcellulose 2.00
Alginate Na 0.50
1,3-butylene glycol 3.00
Alginic acid K 0.50
(Styrene / Vinylpyrrolidone) Copolymer 1.50
B part dimer dilinoleic acid dimer dilinoleyl bis (behenyl / isostearyl /
Phytosteryl) (Plandool-G: Nippon Seika) 0.10
Lauroyl glutamate (phytosteryl / octyldodecyl)
(Plandool-LG2: Nippon Seika) 0.20
Tranexamic acid 2.00
Salicylic acid 0.04
Phytic acid 0.04
3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 0.20
PCA Glyceres-25 isostearate-25 1.50
Ethanol 8.00
PEG / PPG-5 / 30 copolymer 1.00
Ores-10 phosphate DEA 1.00
Glycyrrhizic acid 2K 0.05
Arginine 0.05
Tocopherol 0.10
Methylparaben 0.20
Hyaluronic acid Na 0.05
Na chloride 0.30
Hydroxyethyl ethylenediamine triacetic acid 0.20
Ethylhexyl glycerin 0.02
Maltose 0.50
Fucose 0.50
Mannose 0.50
Fumaric acid 0.05
Sodium fumarate Appropriate amount Purified water Amount to be 100 in total −
(Preparation method)
Part A is heated and swollen at 50 ° C. Gradually add part B to part A with stirring and mix uniformly.

Example 35 Lotion

Component Blending amount (% by weight)
--------------------------------------
Part A Tranexamic acid 2.00
Phytic acid 0.10
Polyacrylic acid 0.02
Carboxymethylcellulose 0.05
Gum arabic 0.03
Purified water 20.00
Part B Dipropylene glycol 2.00
1,3-butylene glycol 2.00
Arbutin 3.00
Ascorbyl glucoside 0.50
3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 1.00
Pyrrolidone carboxylic acid 0.10
Serine 0.10
Glycine 0.10
Betaine 0.10
Royal Jelly Extract 0.10
Nicotinamide 0.10
Citric acid 0.10
Sodium citrate appropriate amount ethanol 8.00
Polyglyceryl diisostearate-3 0.10
Glycolipid, hydrogenated lecithin, BG, purified water 1.00
(Phytopresome MEL: Nippon Seika)
Cyclohexanedicarboxylic acid bisethoxydiglycol 0.50
(Neosolu-Aquorio: Nippon Seika)
Phenoxyethanol 0.20
Photosensitive element 301 0.01
Methylparaben 0.10
EDTA-2Na 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and stirred to give a viscous liquid. Part B was mixed and dissolved uniformly. Part A was added to part B and stirred to dissolve uniformly.

Example 36 Essence

Component Blending amount (% by weight)
--------------------------------------
Part A (acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Hyaluronic acid Na 0.40
Acrylic acid alkyl methacrylate copolymer 0.30
Purified water 20.00
Part B Tranexamic acid 2.00
Etidronic acid 0.07
Phytic acid 0.20
Purified water 18.00
Part C Glycyrrhizic acid 2K 0.10
Dipropylene glycol 2.00
1,3-butylene glycol 5.00
Succinic acid 0.05
Sodium succinate appropriate amount White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.20
Maltose 1.00
Arbutin 1.00
3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 1.00
Glycolipid, hydrogenated lecithin, BG, purified water 1.00
(Phytopresome MEL: Nippon Seika)
Ethanol 5.00
Phenoxyethanol 0.20
Methylparaben 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and stirred to give a viscous liquid. Part B was mixed and dissolved uniformly. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. The mixture was cooled, and A and B parts were added to C part at about 50 ° C. and stirred to make it uniform.

Example 37 Skin Care Cream

Component Blending amount (% by weight)
--------------------------------------
Part A Glycerin 3.00
Squalane 3.00
Jojoba oil 3.00
Palm kernel oil 3.10
Glyceryl stearate 2.30
PEG-60 glyceryl isostearate 1.40
Stearic acid PG (SE) 1.30
Polyglyceryl triisostearate-10 0.50
Stearyl alcohol 3.00
Behenyl alcohol 2.00
Dimethicone 1.50
Lauroyl glutamate (phytosteryl / octyldodecyl)
(Plandool-LG2: Nippon Seika) 1.00
Dimerlinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) (Plandool-H: Nippon Seika) 1.00
Bisdiglyceryl polyacyl adipate-2 0.50
(Plandool-DP: Nippon Seika)
Sunflower seed oil fatty acid phytosteryl 0.50
(Plandool-SUN: Nippon Seika)
Ethylparaben 0.10
Part B stearoxyhydroxypropylmethylcellulose 0.20
Gellan gum 0.50
Acrylic acid alkyl methacrylate copolymer 0.30
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.05
Etidronic acid 0.08
Glutamic acid 0.10
Glycine 0.10
Proline 0.10
Betaine 0.10
Purified water 18.00
Part D Arbutin 3.00
Inulin 0.50
Methylparaben 0.15
Citric acid 0.01
Na citrate Appropriate amount Purified water Amount that will be 100 in total −
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it was made uniform.

Example 38 Oil In Lotion

Component Blending amount (% by weight)
--------------------------------------
Part A Hydrogenated lecithin (Phytocompo-SP: Nippon Seika) 1.00
Glycerin 10.00
1,3-butylene glycol 3.00
B part dimer dilinoleic acid dimer dilinoleyl bis (behenyl / isostearyl /
Phytosteryl) (Plandool-G: Nippon Seika) 0.10
Glyceryl tri-2-ethylhexanoate (IOTG: Nippon Seika) 0.30
Squalane 0.30
Cetanol 0.30
Diethylhexyl succinate 0.20
Dimethicone 0.20
Methyl Gluces-10 3.00
Part C White Jellyfish Polysaccharide (Tremoist-SL: Nippon Seika) 3.00
(Acrylates / alkyl acrylate (C10-30)) cross polymer
0.06
Hydroxide K Appropriate amount Purified water 20.00
Part D Propylene glycol 5.00
Maltose 1.00
Phenoxyethanol 0.20
Methylparaben 0.10
Tranexamic acid 2.00
Phytic acid 0.04
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and heated to about 70 ° C. and dissolved uniformly. Part C was mixed and stirred to give a viscous liquid. Add Part C to Part A, stir and add Part D. After cooling, at about 50 ° C., part B was added and stirred until uniform.

Example 39 Cleansing Gel

Component Blending amount (% by weight)
---------------------------------
Part A 1,2-pentanediol 1.00
Cetyl ethylhexanoate (Nippon Seika) 10.00
Diisobutyl adipate (Nippon Seika) 3.00
Macadamia nut oil fatty acid phytosteryl (Nippon Seika) 1.00
Dimerlinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) (Plandool-H: Nippon Seika) 1.00
Dihydrocholes-30 (Nippon Seika) 2.00
Polyglyceryl dilaurate-10 5.00
PEG-25 hydrogenated castor oil 20.00
Octild Decesse-20 15.00
Glycerin 16.00
BG 5.00
Part B Tranexamic acid 0.50
Phytic acid 0.20
Citric acid 0.10
Maltose 0.50
Arbutin 0.20
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.20
Phenoxyethanol 0.50
Purified water Total amount of 100 ---------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was warmed to about 80 ° C. While stirring, part B was gradually added to part A, and cooled to 40 ° C. after mixing.

Example 40 Body Shampoo

Component Blending amount (% by weight)
---------------------------------
Tranexamic acid 0.50
Macadamia nut oil fatty acid phytosteryl (Nippon Seika) 0.01
Cocoyl Methyl Taurine Na 10.00
Lauroyl hydrolyzed silk Na 6.00
Lauroylmethylalanine Na 10.00
Cocoamphoacetate Na (30%) 4.00
Cocamidopropyl betaine (30%) 10.00
Olefin (C14-16) sulfonic acid Na 5.00
Polyquaternium-10 1.30
Guar hydroxypropyltrimonium chloride 0.80
Acetyl hyaluronic acid Na 0.02
Cocamide DEA 3.00
Phytic acid 0.20
Pentethic acid 0.10
Glutamic acid 0.20
Maltose 0.50
Glucose 0.50
Betaine 0.20
Inulin 0.50
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.05
Glycerin 5.00
Methylparaben 0.20
Purified water Total amount of 100 ---------------------------------
(Preparation method)
All components were heated at about 80 ° C. and stirred and mixed uniformly.

Example 41 Sunscreen cosmetics

Component Blending amount (% by weight)
----------------------------------
Part A Hydrogenated lecithin, phytosterols (Phytocompo-PP: Nippon Seika) 1.00
BG 5.00
1,2-pentanediol 5.00
Glycerin 9.00
Part B Octocrylene 4.00
Octyl salicylate 4.00
Diethylaminohydroxybenzoyl hexyl benzoate 2.25
t-Butylmethoxydibenzoylmethane 1.00
Diethylhexyl sebacate (Nippon Seika) 3.00
Tetraethylhexanoate pentaerythrityl (Nippon Seika) 2.00
Diisobutyl adipate (Nippon Seika) 2.00
Diethylhexyl succinate (Nippon Seika) 2.00
Behenyl alcohol 2.00
Cetearyl alcohol 2.00
Macadamia nut oil fatty acid phytosteryl (Nippon Seika) 1.00
Tocopherol 0.05
Part C Tranexamic acid 1.00
Phytic acid 0.20
Edetic acid 0.20
(Eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
(Neosol-Aqua: Nippon Seika)
Maltose 0.20
Methyl paraben Appropriate amount Water Total amount of 100 parts D Carboxy vinyl polymer (2%) 5.00
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.20
Water-dispersed titanium oxide 5.00
----------------------------------
(Preparation method)
Part A was uniformly dispersed. Part B and part C were each heated to about 70 ° C. and dissolved. After part B was gradually added to part A, part C was gradually added and emulsified. It cooled, stirring, and added D part at 45 degreeC, and stirred.

Example 42 Skin Care Balm

Component Blending amount (% by weight)
----------------------------------
Part A Stearic acid 30.00
Arginine 0.70
Tranexamic acid 2.00
Phytic acid 0.20
(Eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 2.00
(Neosol-Aqua: Nippon Seika)
Bisdiglyceryl polyacyl adipate-2 0.50
(Plandool-DP: Nippon Seika)
Maltose 0.20
Glycerin 3.00
BG 5.00
Benzoic acid Na 0.30
Water Amount that totals 100 ----------------------------------
(Preparation method)
All components were measured, heated to 80 ° C., dissolved, then cooled to 60 ° C. with stirring and filled.

Claims (5)

Cosmetic or skin external preparation containing the following components (A) to (C).
(A) tranexamic acid or a derivative thereof or a salt thereof (B) a reducing sugar or a derivative thereof (C) an acidic component   The component (B) is one or more selected from glucose, fructose, mannose, galactose, xylose, fucose, arabinose, lactose, maltose, cellobiose, and derivatives thereof. The cosmetic or external skin preparation described.   Component (C) is inorganic acid such as phosphoric acid, phosphorous acid, pyrophosphoric acid, metaphosphoric acid, hypophosphorous acid, sulfuric acid, sulfurous acid, pyrosulfurous acid, hydrochloric acid, and esters thereof; acetic acid, butyric acid, propionic acid, sorbic acid , Glycolic acid, lactic acid, citric acid, malic acid, gluconic acid and its dehydrate gluconolactone, tartaric acid, oxalic acid, malonic acid, succinic acid, fumaric acid, maleic acid, glutaric acid, adipic acid, phytic acid, Organic acids such as etidronic acid, edetic acid, pentethic acid, hydroxyethylethylenediamine triacetic acid, benzoic acid, phthalic acid, gallic acid, cinnamic acid, salicylic acid, glutamic acid, aspartic acid; polyacrylic acid, polymethacrylic acid, acrylic acid methacrylic acid Acid alkyl copolymer, carboxyvinyl polymer, carboxymethylcellulose, hyaluronic acid, color It is characterized by being one or more selected from acidic polymer compounds such as Nan, pectin, gum arabic, xanthan gum, gellan gum, agar, white jellyfish polysaccharide, and salts of these acidic components and organic bases The cosmetic or external preparation for skin according to claim 1 or 2.   The cosmetic or external preparation for skin according to any one of claims 1 to 3, wherein the pH is 3 to 7.   The cosmetic or external preparation for skin according to any one of claims 1 to 4, comprising an inorganic base with a base equivalent less than the acid equivalent of component (C).