JP2010265189A - Antibacterial cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic or a skin care preparation in which the use amount of phenoxyethanol, a 1,2-alkanediol, and an alkyl glyceryl ether which are used as antibacterial agents is reduced to thereby reduce the influence of the disadvantages of conventional antibacterial agents such as skin irritation while keeping excellent antibacterial effect. <P>SOLUTION: The antibacterial cosmetic or skin care preparation includes (A) a 6-12C alkyl glucoside, and (B) one or more antibacterial agents selected from phenoxyethanol, a 5-10C 1,2-alkanediol, and a 4-12C monoalkyl glyceryl ether. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

The present invention relates to an antibacterial cosmetic or external preparation for skin containing the following (A) and (B) as essential components.
(A) One or more selected from alkyl glucosides having 6 to 12 carbon atoms (B) phenoxyethanol, 1,2-alkanediol having 5 to 10 carbon atoms, and monoalkyl glyceryl ether having 4 to 12 carbon atoms

  In general, antibacterial agents (preservatives) are blended in cosmetics or skin external preparations for the purpose of suppressing the growth of contaminated microorganisms from the outside and improving the storage stability of the product. As antibacterial agents used for such purposes, parabens (paraoxybenzoic acid esters) and phenoxyethanol are generally used. Reference 1) and alkyl glyceryl ether (see Patent Reference 2). Parabens and phenoxyethanol are excellent antiseptic means for use in cosmetics or external preparations for skin, but are not always satisfactory in terms of skin irritation, and they are not used or used as much as possible. It is desirable to reduce the amount. In addition, 1,2-alkanediol and alkyl glyceryl ether have a narrow antibacterial spectrum, and it is necessary to increase the amount of use in order to exert their antibacterial effect. There is a problem that it is not preferable in terms of touch, and it is required to exhibit a sufficient antibacterial effect even with a smaller amount of use.

  On the other hand, an alkyl glucoside having 6 to 12 carbon atoms is a component that is widely used in cosmetics as a nonionic surfactant having high safety and low skin irritation.

Japanese Patent Laid-Open No. 11-322591 JP 2004-43336 A

  The present invention reduces the amount of phenoxyethanol, 1,2-alkanediol, and alkyl glyceryl ether used as antibacterial agents, and reduces the effects of defects as conventional antibacterial agents such as skin irritation, etc. It aims at providing an external preparation.

  As a result of investigations to solve the above problems, the present inventors have found that one or two selected from phenoxyethanol, 1,2-alkanediol having 5 to 10 carbon atoms, and monoalkyl glyceryl ether having 4 to 12 carbon atoms. The inventors have found that a sufficient antibacterial effect can be obtained even if the amount of the antibacterial agent is reduced by combining an antibacterial agent of more than one species and an alkyl glucoside having 6 to 12 carbon atoms, thereby completing the present invention.

  According to the present invention, the amount of phenoxyethanol, 1,2-alkanediol having 5 to 10 carbon atoms, and monoalkyl glyceryl ether having 4 to 12 carbon atoms can be reduced, and as a conventional antibacterial agent such as skin irritation It is possible to obtain a cosmetic or external preparation for skin that has an excellent antibacterial effect while reducing the influence of the above disadvantages.

Hereinafter, the present invention will be described in detail.
The present invention relates to an antibacterial cosmetic or external preparation for skin containing the following (A) and (B) as essential components.
(A) One or more selected from alkyl glucosides having 6 to 12 carbon atoms (B) phenoxyethanol, 1,2-alkanediol having 5 to 10 carbon atoms, and monoalkyl glyceryl ether having 4 to 12 carbon atoms

  Examples of the alkyl glucoside having 6 to 12 carbon atoms used in the present invention include n-hexyl group, n-heptyl group, n-octyl group, n-nonyl group, n-decyl group, n-undecyl group, and n-dodecyl group. Alkyl glucoside having an alkyl group such as 2-ethylhexyl group and 2-butyloctyl group. Of these, caprylyl glucoside having an n-octyl group is most preferred.

  Examples of the 1,2-alkanediol having 5 to 10 carbon atoms used in the present invention include 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1, Examples include 2-nonanediol and 1,2-decanediol. Of these, 1,2-pentanediol and 1,2-hexanediol are most preferred.

  Examples of the monoalkyl glyceryl ether having 4 to 12 carbon atoms used in the present invention include monobutyl glyceryl ether, monohexyl glyceryl ether, monooctyl glyceryl ether, monoethylhexyl glyceryl ether, monononyl glyceryl ether, monodecyl glyceryl ether, monoundeglyceryl ether Examples include senyl glyceryl ether and monododecyl glyceryl ether. Of these, monoethylhexyl glyceryl ether is most preferred.

  The blending amount of the component (A) in the cosmetic or skin external preparation of the present invention is not particularly limited, but is 0.5 to 3.0% by weight, preferably 0.5 to 1.0% by weight. It is good to mix. The blending amount of component (B) is not particularly limited, but according to the present invention, it is an amount smaller than the blending amount (minimum growth inhibitory concentration) required when the antibacterial agent of normal component (B) is used alone. Can exhibit antibacterial effect. In general, the minimum growth inhibitory concentration (MIC) represents the minimum concentration at which growth was inhibited by confirming the growth of bacteria in a medium containing an antibacterial agent adjusted to each concentration. Usually, the MIC for one compound varies depending on the bacterial species, but in the present invention, it means the highest concentration among the MICs obtained for each bacterial species. Specifically, MIC of phenoxyethanol is 1.0% by weight, 1,2-pentanediol is 4.0% by weight, 1,2-hexanediol is 1.5% by weight, and monoethylhexyl glyceryl ether is 0.2% by weight. Thus, according to the present invention, it is possible to make the amount less than these.

  In the cosmetic or skin external preparation of the present invention, if necessary, additive components generally incorporated into the cosmetic or skin external preparation, for example, an oily base, a moisturizing agent, a touch-improving agent, a surfactant, a polymer , Thickener / gelling agent, solvent, propellant, antioxidant, reducing agent, oxidizing agent, chelating agent, pH adjusting agent, acid, alkali, powder, inorganic salt, UV absorber, whitening agent, vitamins and Derivatives, anti-inflammatory agents, anti-inflammatory agents, hair restoration agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, anti-aging agents, cooling agents, warming agents, wound healing promoters, stimulants Relief agent, analgesic agent, cell activator, plant / animal / microbe extract, antipruritic agent, exfoliating / dissolving agent, antiperspirant, refreshing agent, astringent, enzyme, nucleic acid, fragrance, pigment, colorant, dye, pigment Water, etc. can be blended.

  Examples of these additive components include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, seraalkyl alcohol, batyl. Higher alcohols such as alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylen Acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, ethyl Higher fatty acids such as cosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. Metal soaps, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene , Hydrocarbons such as petroleum jelly and solid paraffin; candelilla wax, carnauba wax, rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax , Petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene / propylene copolymer and other waxes; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, Wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, mint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil Vegetable oils such as peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle Animal fats and oils such as oil; animal oils such as whale wax, lanolin and orange luffy oil Liquid lanolin, reduced lanolin, adsorption purified lanolin, lanolin acetate, acetic acid liquid lanolin, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester, etc. Lanolins: phospholipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phosphatidic acid, lysolecithin, etc .; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid , Phospholipid derivatives such as hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid; cholesterol, dihydrocholesterol, lanosterol, dihi Sterols such as loranosterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / Octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl) Acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, Steroid esters such as macadamia nut oil fatty acid phytosteryl, isostearate phytosteryl, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / phytosterol complex Lipid complexes such as octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononanoyl isononanoate, isononanoic acid Octyl, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, neopentanoic acid Stearyl, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, avocado oil fatty acid Ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate , Monoalcohol carboxylic acid esters such as triethyl citrate; cetyl lactate, dii malate Oxyacid esters such as sostearyl, monoisostearic acid hydrogenated castor oil; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / caprin) Acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, dioctanoic acid Neopentyl glycol, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate Pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearic acid / sebacic acid), pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / rosin acid) Dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate ( Ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopentanoate, 2, dineopentanoic acid 2, Polyhydric alcohol fatty acid esters such as diethyl-1,5-pentanediol; diisopropyl dimerlinoleate, diisostearyl dimerdilinoleate, dimerdilinoleate di (isostearyl / phytosteryl), dimerdilinoleic acid (phytosteryl) / Behenyl), dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearic dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinol Dimer acid or dimer diol derivative such as acid-hardened castor oil, hydroxyalkyl dimer linoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanola Amide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide ( Fatty acid alkanolamides such as partamide DEA) and palm oil fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopenta) Siloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylamino) (Ropylemethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicone such as dimethicone copolyol, polyglycerin-modified silicone, sugar Modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone, peptide modified silicone, fluorine modified silicone, cation modified and polyether modified silicone, Amino- and polyether-modified silicones, alkyl- and polyether-modified silicones, Silicones such as hexane-polyoxyalkylene copolymer; perfluorodecane, perfluorooctane, fluorine-based oils such as perfluoropolyether may be mentioned as preferred.

  As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosane diacid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan Sulfuric acid; white jellyfish extract; white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium Salt: betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, aspa Amino acids such as gin, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and the salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagenolytic peptide, hydrolyzed collagen, Hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat protein Degraded peptides, hydrolyzed wheat protein, casein-degraded peptides, acylated peptides and other protein peptides and their derivatives; palmitoyl oligopeptides , Acylated peptides such as palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, glutathione, albumin, milk Chin; choline chloride, phosphorylcholine; placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract, merirot extract Preferred are ceramides such as animal and plant extract components such as natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide, and sugar-ceramide-containing extracts. All It is.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium phosphate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonate; alkylsulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and tetraethanolamine tetraethanol; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laurethrin Alkyl ether phosphates such as sodium, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide ether phosphorus Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants, laureth (Polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez (polyoxyethylene) Nbehenyl ethers), isosteares (polyoxyethylene isostearyl ethers), octyldecesses (polyoxyethylene octyldodecyl ethers) and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, poly Castor oil such as oxyethylene hydrogenated castor oil maleic acid and hydrogenated castor oil derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxy Polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene polyoxypropylene monobutyl ether, polyoxyethylene lanolin; Oxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, myristate group Glyceryl fatty acid partial esters such as ceryl, glyceryl oleate, glyceryl coconut oil fatty acid, glyceryl mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, α, α'-oleic acid pyroglutamate glycerin, monostearate glycerin malate; Polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, polyglyceryl isostearate -2, 3, 4, 5, 6, 8, 10, diglycostyl diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl tetraisostearate Ril-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3,4, 5,6, 8,8, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol moieties Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monos Sorbitan fatty acid esters such as allate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside fatty acid ester, trehalose undecylenate, etc. Partial derivatives of sugar derivatives; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohols; reduced lanolin; polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene di- Polyoxyethylene fatty acid mono- and diesters such as oleate; polyoxyethylene propylene glycol fatty acid ester; polyoxyethylene Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as polyglycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxy Polyoxyethylene sorbitan fatty acid esters such as ethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol penta Polyoxyethylene sorbitol fatty acid esters such as oleate and polyoxyethylene sorbitol monostearate Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; Alkyl such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, batyl alcohol Glyceryl ethers; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil Fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (laura) De-MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl) Fatty acid alkanolamides such as MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; poly such as dimethicone copolyol Silicone such as ether-modified silicone, polysiloxane-oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone Nonionic surfactants, etc .; for cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; alkyls such as stearyltrimonium bromide Trialkylammonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ether amines such as stearoxypropyldimethylamine; Salt or quaternary salt thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl lanolin sulfate Fatty acid amide-type quaternary ammonium salts such as aminopropylethyldimethylammonium fatty acid; polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; Silicone-based cationic surfactants such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone;
In amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as laurylbetaine (lauryldimethylaminoacetic acid betaine); fatty acid amidoalkyl-N, N-dimethylamino acids such as cocamidopropylbetaine and lauramidopropylbetaine Betaines; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; Sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated Soy phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as hydroxylated lecithin; silicone-based amphoteric surfactants; polymer surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, Preferred are tragacanth gum, acrylic acid / alkyl methacrylate copolymer; and various silicone surfactants.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationic cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

  Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid-based UV absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone purple 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2′-hydroxy-5- 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphsulfone Preference is given to acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

  Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbate phosphate and magnesium ascorbate phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylreso Shinoru, oil-soluble Kamomiraekisu, oil-soluble licorice extract, Nishikawa willow extract, be mentioned as saxifrage extract, and the like plant extracts are preferred.

  Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

  Plant / animal / microbe extracts include iris extract, ashitaba extract, asunaro extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.

As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Arianor Sienna Brown, Arianor Madder Red, Arianor
Basic dyes such as Steel Blue and Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-
Nitro dyes such as phenylenediamine, HC Blue 2, and Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (Bengara) and iron titanate; and γ-iron oxide Inorganic brown pigments; inorganic yellow pigments such as yellow iron oxide and ocher; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; chromium oxide and chromium hydroxide Inorganic green pigments such as cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil Pearl powder such as aluminum powder, copper powder, metal powder pigment such as gold; surface treatment inorganic and metal powder pigment; red 01, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404 Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green Organic pigments such as zirconium, barium or aluminum lakes such as No. 3 and Blue No. 1; surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, Naphthoquinones such as chlorophyll, curcumin, cochineal, shikonin, bixin, flavo Natural pigments and dyes such as amines, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylene Oxidative dye intermediates and couplers such as diamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; auto-oxidizing dyes such as indoline; Can be mentioned.

  Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  Examples of the antibacterial cosmetic or skin external preparation of the present invention include skin external preparations such as hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and ointments. . The cosmetic / skin external preparation of the present invention can be produced according to a usual method.

  The antibacterial cosmetic or skin external preparation of the present invention will be described in more detail. Examples of hair cosmetics include oil shampoo, cream shampoo, conditioning shampoo, dandruff shampoo, hair color shampoo, and rinse integrated shampoo. Shampoos such as: rinse, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow, Split coat, hair oil, permanent wave agent, straight permanent agent, oxidative hair dye, hair bleach, hair color pretreatment, hair color after treatment, permanent pretreatment, Ma after treatments, hair manicure, and as hair growth agents are preferred.

  Basic cosmetics include soft lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, nari Thing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, sun makeup cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; liposome Liposome cosmetics such as beauty essence and liposome lotion; Peel-off packs, powder packs, washing packs, oil packs, cleansing masks and other packs and masks; cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels, cleansing oils , Cleansing mask, washing powder, face washing powder, etc .; cosmetic soap, transparent soap, medicated soap, liquid soap, shaving soap, synthetic cosmetic soap Soap can be mentioned as preferred.

  Examples of makeup cosmetics that may be preferably used include white powder, dusts, foundations, lipsticks, lip gloss, blushers, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment.

  Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.

  Body cosmetics such as body shampoos; deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics; decoloring agents, hair removal / hair removal agents; bathing agents; insect repellents A repeller is preferred.

  Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

  Examples of the dosage form of the antibacterial cosmetic or skin external preparation of the present invention include an oil-in-water (O / W) type, a water-in-oil (W / O) type, a W / O / W type, and an O / W / O type. Emulsified cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, kneaded cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics , Paste-type cosmetics, emulsified polymer-type cosmetics, sheet-type cosmetics, mist-type cosmetics, spray-type cosmetics, and the like are preferable.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example, this invention is not limited to these Examples.

Examples 1-18, Comparative Examples 1-9
The lotion which mix | blended phenoxyethanol and octyl glucoside with the composition of Table 1 was prepared (Examples 1-6), and the lotion which did not mix | blend octyl glucoside was prepared as a comparison (Comparative Examples 1-3). Moreover, the lotion which mix | blended 1,2-pentanediol and octyl glucoside with the composition of Table 2 was prepared (Examples 7-12), and the lotion which did not mix | blend octyl glucoside was prepared as a comparison (comparative example 4). ~ 6). Furthermore, the lotion which mix | blended monoethylhexyl glyceryl ether and octyl glucoside with the composition of Table 3 was prepared (Examples 13-18), and the lotion which did not mix | blend octyl glucoside was prepared as a comparison (Comparative Examples 7-9) ).

Antibacterial Evaluation For the lotions of Examples 1 to 18 and Comparative Examples 1 to 9, antibacterial evaluation against general viable bacteria was performed.

(Evaluation methods)
The test method is as follows. First, a liquid medium containing 2.0% by weight of gazein peptone and 1.0% by weight of sodium chloride in purified water is prepared, and left in the room for 6 hours in order to take airborne bacteria into the medium. After that, preliminary culture was performed for 24 hours. The liquid medium preliminarily cultured after 24 hours and the test lotion were mixed in equal amounts, and further cultured for 3 days. Three days later, 1 mL of the culture solution was added to Petrifilm ^TM medium (manufactured by Sumitomo 3M) and cultured for 24 hours. Moreover, it tested similarly about what added purified water instead of the test lotion, and it was set as the positive control. After 24 hours, the number of bacteria growing on the Petrifilm ^TM medium was visually observed to evaluate antibacterial properties. Evaluation was performed in the following three stages.

○: Bacteria died △: Bacterial growth was suppressed compared to positive control ×: Bacteria propagated to the same degree or more than positive control

(result)
The results are shown in Tables 1-3. In the lotions of Comparative Examples 1 to 9 not containing octyl glucoside, antibacterial properties could not be confirmed when the concentration of the antibacterial agent of component (B) was decreased, whereas Example 1 of the present invention containing octyl glucoside was used. It was confirmed that -18 lotions had an antibacterial effect even at a concentration that did not have an antibacterial effect in Comparative Examples. Therefore, according to this invention, it turned out that the compounding quantity of the antibacterial agent of a component (B) can be reduced.

Example 19 Lotion Toner lotion having the following formulation was prepared. Even if this lotion was stored at 40 ° C. for 3 months, no bacteria were generated and the antibacterial property was excellent.

Component Blending amount (% by weight)
--------------------------------
1 Phenoxyethanol 0.20
2 Octyl glucoside (50%) 1.00
3 BG 1.00
4 Glycerin 2.00
5 Citric acid 0.01
6 Na citrate 0.10
7 Arginine 0.10
8 Glycyrrhizic acid 2K 0.05
9 Ethanol 7.00
10 Fragrance
11 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1-7 are No. 11 and stirred and mixed uniformly (part A). Next, no. No. 10 After dissolution in No. 9, no. 8 was added and dispersed (part B). A part was added to part B with stirring to make it uniform.

Example 20 Lotion Toner lotion having the following formulation was prepared. Even if this lotion was stored at 40 ° C. for 3 months, no bacteria were generated and the antibacterial property was excellent.

Component Blending amount (% by weight)
--------------------------------
1 1,2-pentanediol 1.00
2 Octyl glucoside (50%) 1.00
3 BG 1.00
4 Glycerin 2.00
5 Citric acid 0.01
6 Na citrate 0.10
7 Arginine 0.10
8 Glycyrrhizic acid 2K 0.05
9 Ethanol 7.00
10 Fragrance
11 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1-7 are No. 11 and stirred and mixed uniformly (part A). Next, no. No. 10 After dissolution in No. 9, no. 8 was added and dispersed (part B). A part was added to part B with stirring to make it uniform.

Example 21 Lotion Toner lotion having the following formulation was prepared. Even if this lotion was stored at 40 ° C. for 3 months, no bacteria were generated and the antibacterial property was excellent.


Component Blending amount (% by weight)
--------------------------------
1 Monoethylhexyl glyceryl ether 0.05
2 Octyl glucoside (50%) 1.00
3 BG 1.00
4 Glycerin 2.00
5 Citric acid 0.01
6 Na citrate 0.10
7 Arginine 0.10
8 Glycyrrhizic acid 2K 0.05
9 Ethanol 7.00
10 Fragrance
11 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1-7 are No. 11 and stirred and mixed uniformly (part A). Next, no. No. 10 After dissolution in No. 9, no. 8 was added and dispersed (part B). A part was added to part B with stirring to make it uniform.

Example 22 Cosmetic liquid A cosmetic liquid having the following formulation was prepared. Even when stored at 40 ° C. for 3 months, this cosmetic solution was free of bacteria and was excellent in antibacterial properties.

Component Blending amount (% by weight)
--------------------------------
Part A phenoxyethanol 0.20
Octyl glucoside (50%) 1.00
PEG-40 hydrogenated castor oil 0.20
Purified water 10.00
Part B xanthan gum 0.40
Carbomer 0.10
BG
10.00
White jellyfish polysaccharide (Nippon Seika) 0.10
Purified water Amount to be 100 in total C part Hydroxide K (1% aqueous solution) 2.50
Purified water 10.00
Part D glycyrrhizic acid 2K 0.20
Purified water 5.00
--------------------------------
(Production method)
Part A was dissolved at room temperature. C. Part C was gradually added to part B while stirring to obtain a viscous liquid, and then parts A and D were added and stirred to make uniform.

Example 23 Cosmetic liquid A cosmetic liquid having the following formulation was prepared. Even when stored at 40 ° C. for 3 months, this cosmetic solution was free of bacteria and was excellent in antibacterial properties.

Component Blending amount (% by weight)
--------------------------------
Part A 1,2-pentanediol 1.00
Octyl glucoside (50%) 1.00
PEG-40 hydrogenated castor oil 0.20
Purified water 10.00
Part B xanthan gum 0.40
Carbomer 0.10
BG
10.00
White jellyfish polysaccharide (Nippon Seika) 0.10
Purified water Amount to be 100 in total C part Hydroxide K (1% aqueous solution) 2.50
Purified water 10.00
Part D glycyrrhizic acid 2K 0.20
Purified water 5.00
--------------------------------
(Production method)
Part A was dissolved at room temperature. C. Part C was gradually added to part B while stirring to obtain a viscous liquid, and then parts A and D were added and stirred to make uniform.

Example 24 Cosmetic liquid A cosmetic liquid having the following formulation was prepared. Even when stored at 40 ° C. for 3 months, this cosmetic solution was free of bacteria and was excellent in antibacterial properties.

Component Blending amount (% by weight)
--------------------------------
Part A monoethylhexyl glyceryl ether 0.10
Octyl glucoside (50%) 1.00
PEG-40 hydrogenated castor oil 0.20
Purified water 10.00
Part B xanthan gum 0.40
Carbomer 0.10
BG
10.00
White jellyfish polysaccharide (Nippon Seika) 0.10
Purified water Amount to be 100 in total C part Hydroxide K (1% aqueous solution) 2.50
Purified water 10.00
Part D glycyrrhizic acid 2K 0.20
Purified water 5.00
--------------------------------
(Production method)
Part A was dissolved at room temperature. C. Part C was gradually added to part B while stirring to obtain a viscous liquid, and then parts A and D were added and stirred to make uniform.

Example 25 Shampoo A shampoo having the following formulation was prepared. This shampoo was excellent in antibacterial properties without generation of bacteria even when stored at 40 ° C. for 3 months.

Component Blending amount (% by weight)
--------------------------------
1 Phenoxyethanol 0.50
2 Octyl glucoside (50%) 1.00
3 Cocamidopropyl betaine (40%) 40.00
4 Cocoa glutamate TEA (27%) 10.00
5 Tetradecenesulfonic acid Na (36%) 2.00
6 PEG120-methylglucose dioleate 3.00
7 Triethanolamine 0.20
8 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 6 were heated to about 80 ° C. and dissolved uniformly (part A). Next, no. 7 to 8 were heated to about 80 ° C. and dissolved uniformly (part B). Part B was added to part A and mixed with stirring at about 80 ° C. until uniform, and then cooled.

Example 26 Shampoo A shampoo having the following formulation was prepared. This shampoo was excellent in antibacterial properties without generation of bacteria even when stored at 40 ° C. for 3 months.

Component Blending amount (% by weight)
--------------------------------
1 1,2-pentanediol 1.00
2 Octyl glucoside (50%) 1.00
3 Cocamidopropyl betaine (40%) 40.00
4 Cocoa glutamate TEA (27%) 10.00
5 Tetradecenesulfonic acid Na (36%) 2.00
6 PEG120-methylglucose dioleate 3.00
7 Triethanolamine 0.20
8 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 6 were heated to about 80 ° C. and dissolved uniformly (part A). Next, no. 7 to 8 were heated to about 80 ° C. and dissolved uniformly (part B). Part B was added to part A and mixed with stirring at about 80 ° C. until uniform, and then cooled.

Example 27 Shampoo A shampoo having the following formulation was prepared. This shampoo was excellent in antibacterial properties without generation of bacteria even when stored at 40 ° C. for 3 months.

Component Blending amount (% by weight)
--------------------------------
1 Monoethylhexyl glyceryl ether 0.10
2 Octyl glucoside (50%) 1.00
3 Cocamidopropyl betaine (40%) 40.00
4 Cocoa glutamate TEA (27%) 10.00
5 Tetradecenesulfonic acid Na (36%) 2.00
6 PEG120-methylglucose dioleate 3.00
7 Triethanolamine 0.20
8 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 6 were heated to about 80 ° C. and dissolved uniformly (part A). Next, no. 7 to 8 were heated to about 80 ° C. and dissolved uniformly (part B). Part B was added to part A and mixed with stirring at about 80 ° C. until uniform, and then cooled.

Example 28 Treatment A treatment having the following formulation was prepared. This treatment was excellent in antibacterial properties without generation of bacteria even when stored at 40 ° C. for 3 months.

Component Blending amount (% by weight)
--------------------------------
1 Cetanol 5.00
2 Oleyl alcohol 1.00
3 Olive oil 2.00
4 Glyceryl stearate 1.00
5 Zicococomonium chloride 0.80
6 Behentrimonium chloride (80%) 2.40
7 Tocopherol 0.05
8 Phenoxyethanol 0.20
9 Octyl glucoside (50%) 1.00
10 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 7 were heated to about 70 ° C. and dissolved uniformly (part A). No. 8 to 10 were heated to about 70 ° C. and uniformly dissolved (Part B). Part B was added to Part A and stirred and mixed uniformly, and then cooled to room temperature.

Example 29 Treatment A treatment having the following formulation was prepared. This treatment was excellent in antibacterial properties without generation of bacteria even when stored at 40 ° C. for 3 months.

Component Blending amount (% by weight)
--------------------------------
1 Cetanol 5.00
2 Oleyl alcohol 1.00
3 Olive oil 2.00
4 Glyceryl stearate 1.00
5 Zicococomonium chloride 0.80
6 Behentrimonium chloride (80%) 2.40
7 Tocopherol 0.05
8 1,2-pentanediol 1.00
9 Octyl glucoside (50%) 1.00
10 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 7 were heated to about 70 ° C. and dissolved uniformly (part A). No. 8 to 10 were heated to about 70 ° C. and dissolved uniformly (Part B). Part B was added to Part A and stirred and mixed uniformly, and then cooled to room temperature.

Example 30 Treatment A treatment having the following formulation was prepared. This treatment was excellent in antibacterial properties without generation of bacteria even when stored at 40 ° C. for 3 months.

Component Blending amount (% by weight)
--------------------------------
1 Cetanol 5.00
2 Oleyl alcohol 1.00
3 Olive oil 2.00
4 Glyceryl stearate 1.00
5 Zicococomonium chloride 0.80
6 Behentrimonium chloride (80%) 2.40
7 Tocopherol 0.05
8 Monoethylhexyl glyceryl ether 0.10
9 Octyl glucoside (50%) 1.00
10 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 7 were heated to about 70 ° C. and dissolved uniformly (part A). No. 8 to 10 were heated to about 70 ° C. and uniformly dissolved (Part B). Part B was added to Part A and stirred and mixed uniformly, and then cooled to room temperature.

Example 31 Emollient Cream An emollient cream having the following formulation was prepared. Even when stored at 40 ° C. for 3 months, no bacteria were generated and the antibacterial property was excellent.

Component Blending amount (% by weight)
--------------------------------
1 Hydrogenated palm oil 2.50
2 Behenyl alcohol 2.00
3 Dimethicone (10cs) 1.50
4 Glyceryl stearate 1.50
5 Stearyl alcohol 1.20
6 Stearic acid PG (SE) 1.00
7 PEG-60 glyceryl isostearate 1.00
8 Octyl methoxycinnamate 0.20
9 Phenoxyethanol 0.20
10 Octyl glucoside (50%) 1.00
11 1,3-butylene glycol 6.00
12 Glycerin 1.00
13 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1-9 were added, and it heated and dissolved at about 80 degreeC (part A). No. in a separate container. 10-13 was heated to about 80 ° C. and dissolved uniformly (part B). Part B was added to part A, emulsified with a homomixer, and then cooled to 40 ° C.

Example 32 Emollient Cream An emollient cream having the following formulation was prepared. Even when stored at 40 ° C. for 3 months, no bacteria were generated and the antibacterial property was excellent.

Component Blending amount (% by weight)
--------------------------------
1 Hydrogenated palm oil 2.50
2 Behenyl alcohol 2.00
3 Dimethicone (10cs) 1.50
4 Glyceryl stearate 1.50
5 Stearyl alcohol 1.20
6 Stearic acid PG (SE) 1.00
7 PEG-60 glyceryl isostearate 1.00
8 Octyl methoxycinnamate 0.20
9 1,2-pentanediol 1.00
10 Octyl glucoside (50%) 1.00
11 1,3-butylene glycol 6.00
12 Glycerin 1.00
13 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1-9 were added, and it heated and dissolved at about 80 degreeC (part A). No. in a separate container. 10-13 was heated to about 80 ° C. and dissolved uniformly (part B). Part B was added to part A, emulsified with a homomixer, and then cooled to 40 ° C.

Example 33 Emollient cream An emollient cream having the following formulation was prepared. Even when stored at 40 ° C. for 3 months, no bacteria were generated and the antibacterial property was excellent.

Component Blending amount (% by weight)
--------------------------------
1 Hydrogenated palm oil 2.50
2 Behenyl alcohol 2.00
3 Dimethicone (10cs) 1.50
4 Glyceryl stearate 1.50
5 Stearyl alcohol 1.20
6 Stearic acid PG (SE) 1.00
7 PEG-60 glyceryl isostearate 1.00
8 Octyl methoxycinnamate 0.20
9 Monoethylhexyl glyceryl ether 0.10
10 Octyl glucoside (50%) 1.00
11 1,3-butylene glycol 6.00
12 Glycerin 1.00
13 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1-9 were added, and it heated and dissolved at about 80 degreeC (part A). No. in a separate container. 10-13 was heated to about 80 ° C. and dissolved uniformly (part B). Part B was added to part A, emulsified with a homomixer, and then cooled to 40 ° C.

Claims (5)

Antibacterial cosmetic or skin external preparation comprising the following (A) and (B) as essential components (A) C6-C12 alkyl glucoside (B) Phenoxyethanol, C5-C10 1,2-alkane One or more selected from diols and monoalkyl glyceryl ethers having 4 to 12 carbon atoms   The cosmetic or external skin preparation according to claim 1, wherein (A) is caprylyl glucoside.   The antibacterial agent other than (B) is substantially not blended, The cosmetic or external preparation for skin according to claim 1 or 2   The cosmetic or skin external preparation according to any one of claims 1 to 3, wherein component (A) is blended in an amount of 0.5 to 3.0% by weight.   The cosmetic or skin external preparation according to any one of claims 1 to 4, wherein the blending amount of the component (B) is blended at a concentration lower than the minimum inhibitory concentration of the component (B).