JP5805466B2 - Diester composition for cosmetics or external preparation for skin having lamella forming ability - Google Patents

Description

  The present invention relates to a cosmetic or skin external preparation diester composition having a lamellar forming ability, and a cosmetic and a skin external preparation containing the composition.

  It is known that dry skin not only causes rough skin and fine lines, but also triggers itching and inflammation. Preventing dry skin keeps the skin beautiful and healthy, and prevents and treats skin diseases. It is also important. It is known that the stratum corneum consisting of only about 20 μm of the outermost layer of the skin is greatly involved in the drying of the skin, and it is important to keep the moisture retention function and skin barrier function of the stratum corneum normal. Become.

  The stratum corneum has a structure in which the stratum corneum forms a layer structure of 10 to 20 layers, and the space between the stratum corneum is filled with lipids between corneocytes, as exemplified by the relationship between the block and the mortar forming the block coral. doing. The stratum corneum intercellular lipid not only supports the stratum corneum by adhering the stratum corneum to the stratum corneum, but also plays an important role in water retention and barrier function of the stratum corneum. It is considered that the water retention / barrier function of the keratinocyte lipid is largely related to the structure formed by the keratinocyte lipid. In other words, stratum corneum lipids are mainly composed of ceramide, cholesterol, and fatty acids, but have a layered structure (lamellar structure) sandwiching water. Such a lamellar structure holds water and releases it to the outside. It is thought that by controlling the transpiration of moisture, it contributes to the moisture retention and barrier function of the stratum corneum.

  In skin cosmetics or external preparations for skin, oils such as hydrocarbon oils and ester oils are generally used as a kind of moisturizing component for the purpose of suppressing moisture transpiration from the skin and imparting flexibility to the skin. Moreover, the oil agent which has water retention property is preferably used from the viewpoint of enhancing the moisturizing effect. On the other hand, if it is an oil agent that forms a lamellar structure in the same manner as intercellular lipids, it is expected to have a better moisturizing effect and further an effect of improving the barrier function of the stratum corneum with an action different from that of the above oil agent. As such an oil agent that forms a lamellar structure, an ester compound of a long-chain fatty acid and a sterol is known (Patent Document 1).

  In recent years, surfactants and oil agents having an amino acid skeleton have been widely used as cosmetic raw materials from the viewpoint of high safety and low environmental impact. As one of such oil agents, Patent Document 2 discloses a diester of N-lauroyl-L-glutamic acid and a mixed alcohol composed of sterol and higher alcohol, which is emulsifiable as an oil agent for cosmetics. It is known to have excellent water retention. However, it is not known that the diester forms a lamellar structure.

JP-A-9-132512 Japanese Patent Laid-Open No. 3-275597

  The subject of this invention is providing the oil agent for cosmetics or the skin external preparation which is an oil-based component which has an amino acid frame | skeleton, and has the outstanding lamellar formation ability.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that a diester composition of N-lauroyl-L-glutamic acid and a mixed alcohol composed of a specific ratio of phytosterol and behenyl alcohol solves the above problems. The present invention has been completed.

  The diester composition of the present invention can form a lamellar structure by mixing with water, and exhibits excellent moisturizing / skin barrier function improving effects.

  The oil of the present invention is a diester composition of N-lauroyl-L-glutamic acid and a mixed alcohol composed of phytosterol and behenyl alcohol, wherein the molar ratio of behenyl alcohol to phytosterol in the mixed alcohol is 3 to 9, To do. Further, 2-octyldodecanol may be contained as a mixed alcohol. In this case, the content of 2-octyldodecanol is 20 mol% or less in the total alcohol, and the molar ratio of behenyl alcohol to phytosterol is 3-9.

  Phytosterol and behenyl alcohol are used as the mixed alcohol used in the production of the diester composition of the present invention. Phytosterol is a general term for sterols contained in plants, and β-sitosterol, stigmasterol, campesterol, brush casterol and the like are known as main components. The phytosterol used in the present invention is not limited to these compounds and may be any sterol obtained from a plant. Behenyl alcohol is a saturated straight chain higher alcohol having 22 carbon atoms. As commercial products, those containing about 10 to 40% by weight of saturated straight chain higher alcohols having 14 to 20 carbon atoms in addition to behenyl alcohol are generally available, and such commercial products can be used in the present invention. The ratio of phytosterol and behenyl alcohol in the mixed alcohol is 3 to 9 mol of behenyl alcohol with respect to 1 mol of phytosterol. Even if the amount of behenyl alcohol relative to phytosterol is less than the above range, at most, the formation of the lamellar structure, which is a feature of the present invention, is insufficient.

  Phytosterol and behenyl alcohol are essential for the mixed alcohol used in the production of the diester composition of the present invention, but 2-octyldodecanol may further be included. By including 2-octyldodecanol, the melting point of the obtained diester composition is lowered, so that the handling property can be improved. On the other hand, when the content of 2-octyldodecanol increases, even if the ratio of phytosterol and behenyl alcohol is within the range of the present invention, the formation of the lamellar structure becomes insufficient. Therefore, the content of 2-octyldodecanol needs to be 20 mol% or less in all alcohols (phytosterol, behenyl alcohol, 2-octyldodecanol).

  The diester composition of the present invention can be produced by esterifying N-lauroyl-L-glutamic acid and phytosterol and behenyl alcohol, or a mixed alcohol composed of phytosterol, behenyl alcohol and 2-octyldodecanol. The reaction ratio of N-lauroyl-L-glutamic acid and mixed alcohol is preferably 2 to 3 moles, preferably 2 moles or more of mixed alcohol per 1 mole of N-lauroyl-L-glutamic acid. The reaction is preferably performed using 2-2.5 mol. The method of esterification is not particularly limited, and is performed by a commonly used method. For example, paratoluenesulfonic acid, sulfuric acid, hydrochloric acid, methanesulfonic acid, boron trifluoride diethyl ether complex or the like is used as a catalyst, and heptane, hexane, cyclohexane, toluene, xylene or the like is used as a solvent at 50 to 260 ° C. be able to. Furthermore, you may refine | purify and use the obtained diester composition by a normal method as needed.

  The diester composition of the present invention may contain components other than the diester composition of the present invention, such as other oily bases and antioxidants. The diester composition of the present invention is excellent in oxidation stability, but the oxidation stability can be further improved by adding an antioxidant. As the antioxidant, those usually added to an oily base such as vitamins E, BHT, and BHA can be used, but the use of vitamins E is particularly desirable. Vitamin E was isolated and purified from d-α-tocopherol, d-δ-tocopherol, d, l-α-tocopherol, d-α-tocopherol acetate, d, l-α-tocopherol acetate, soybean and rapeseed. Tocopherol mixtures and the like can be used. Although there is no restriction | limiting in particular in the addition amount of antioxidant, About 10 ppm-10000 ppm are suitable with respect to the weight of the ester of this invention.

  The diester composition obtained as described above can form a lamellar structure by mixing with water, and can be preferably used for cosmetics and skin external preparations. The blending amount of the diester composition of the present invention into the cosmetic and the external preparation for skin is not particularly limited, but is preferably about 0.01 to 60% by weight, more preferably 0.05 to 40% by weight. In addition, the cosmetics of the present invention may contain water and, as necessary, additives added to normal cosmetics and skin external preparations, such as oil bases, surfactants, alcohols, humectants, polymers, thickeners, Gelling agent, antioxidant, antiseptic, bactericidal agent, chelating agent, pH adjuster / acid / alkali, UV absorber, whitening agent, solvent, exfoliating / dissolving agent, antipruritic agent, anti-inflammatory agent, antiperspirant, Refreshing agents, antihistamines, astringents, stimulants, hair growth agents / blood circulation promoters, reducing agents / oxidants, polymer powders, hydroxy acids, vitamins and derivatives thereof, saccharides and derivatives thereof, organic acids, enzymes , Nucleic acids, hormones, inorganic powders, fragrances, pigments and the like can be blended.

  Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as cannic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Type hydrocarbons such as candelilla wax, carnauba wax, rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Tropsch wax, polyethylene wax, waxes such as ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cacao butter, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Fats and oils; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, Phospholipid derivatives such as partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytoster Sterols such as oleol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl ), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N Acyl sarcosine alkyl esters such as lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phyto Sterol esters such as steryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / phytosterol complex, etc. Lipid complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl parmitate, octyldodecyl palmitate, cetyl octanoate, hexyl decyl octanoate, isotridecyl isononanoate, isononyl isononanoate, isononanoate Isotridecyl acid, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octeodecanoate Ludodecyl, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, ethyl avocado oil, isopropyl myristate , Isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, methyl heptyl laurate, methyl heptyl myristate, methyl heptyl palmitate, methyl heptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, adipine Diisopropyl acid, dibutyl octyl sebacate, diisobutyl adipate, dioctyl succinate Monoalcohol carboxylates such as triethyl citrate; oxyacid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, γ-ercalactone; glyceryl trioctanoate, glyceryl trioleate, Glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic acid / capric acid), tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester) Gum), glyceryl eicosandioate behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl dicaprate Coal, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, (isostearic acid / sebacin Acid) ditrimethylolpropane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / rosin acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid) / Ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (distea) Polyethylene alcohol fatty acid esters such as ethylene glycol phosphate), dineopentanoic acid 3-methyl-1,5-pentanediol, dineopentanoic acid 2,4-diethyl-1,5-pentanediol; diisopropyl linoleate diisopropyl, dimer Diisostearyl linoleate, dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate (phytosteryl / behenyl), dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleate Dimer acid such as merlinoleyl, diisostearic acid dimerinolinole, dimer linoleyl hydrogenated rosin condensate, dimer linoleic acid hydrogenated castor oil, hydroxyalkyl dimer linoleyl ether or the like Derivatives of imerdiol: coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide Fatty acid alkanolamides such as (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), high polymerization Dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethy , Diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, aminopropyl dimethicone and amodimethicone, cation Polyether modified silicone such as modified silicone and dimethicone copolyol, polyglycerin modified silicone, sugar modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid Modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone Silicone such as lycon, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, polysiloxane / oxyalkylene copolymer; fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether Can be mentioned as preferred.

  As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosane diacid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan Sulfuric acid; white jellyfish extract; white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium Salt: betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, aspa Amino acids such as gin, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and the salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagenolytic peptide, hydrolyzed collagen, Hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat protein Degraded peptides, hydrolyzed wheat protein, casein-degraded peptides, acylated peptides and other protein peptides and their derivatives; palmitoyl oligopeptides , Acylated peptides such as palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, glutathione, albumin, milk Chin; choline chloride, phosphorylcholine; placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract, merirot extract Preferred are ceramides such as animal and plant extract components such as natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide, and sugar-ceramide-containing extracts. All It is.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium phosphate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine, lysine Na dilauroyl glutamate; sodium laureth acetate, etc. Polyoxyethylene alkyl ether acetates; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; Fatty acid glyceride sulfate such as coconut oil fatty acid sodium glycerin sulfate; Oxyethylene sulfate; Olefin sulfonate such as sodium α-olefin sulfonate; Alkyl sulfosuccinate such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; Disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate Alkyl ether sulfosuccinates such as sodium acid, sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonate; alkanesulfonate; α-sulfo fatty acid methyl ester salt; acyl isethionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetates; alkyl ether phosphates such as sodium laureth phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate esters such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphorus Fatty acid amide ether phosphates; Phospholipids such as phosphatidylglycerol, phosphatidylinositol and phosphatidic acid; Silicone anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone and sulfuric acid-modified silicone; Among the ionic surfactants, laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether) ), Behenes (polyoxyethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether), octyldecesses (polyoxyethylene octyldodecyl ether), and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers Polyoxyethylene alkyl phenyl ether; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil Castor oil and hydrogenated castor oil derivatives such as monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polio Polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / poly Oxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; PPG-9 di (Poly) glycerin polyoxypropylene glycol such as glyceryl; glyceryl stearate, glyceryl isostearate, Glyceryl mycinate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-oleate pyroglutamate, glyceryl monostearate malate, etc. Glycerin fatty acid partial esters: polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl-6 distearate, 10, polyglyceryl tristearate, polyglyceryl decastearate -10, polyglyceryl isostearate 2, 3, 4, 5, 6, 8, 10, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 10, polyglyceryl triisostearate 2, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 8, dioleate polyglyceryl-6, trioleate polyglyceryl -2, polyglyceryl fatty acid ester such as polyglyceryl-10 dekaoleate; ethylene glycol mono fatty acid ester such as ethylene glycol monostearate; propylene glycol mono fatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid Maltitol partial fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbita Sorbitan fatty acid esters such as monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside Sugar ester partial esters such as fatty acid esters and undecylenic acid trehalose; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohols; reduced lanolins; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene mono Polyoxyethylene fatty acid mono- and diesters such as oleate and polyoxyethylene dioleate; polyoxyethylene propylene glycol Polyoxyethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol fatty acid esters such as polyoxyethylene monooleate such as polyoxyethylene glycerol triisostearate; polyoxyethylene Polyoxyethylene sorbitan fatty acid esters such as sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate Polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate, etc. Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable fats and oils such as polyoxyethylene sorbitol beeswax; Isostearyl glyceryl ether, chimyl alcohol, seraalkyl alcohol, batyl Alkyl glyceryl ethers such as alcohols; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acids Amides; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), la Phosphoric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamic acid MEA), palmitic acid diethanolamide (partamic acid DEA), coconut oil Fatty acid alkanolamides such as fatty acid methylethanolamide (cocamidomethyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkylmercaptan; Polyether-modified silicone such as dimethicone copolyol, polysiloxane-oxyalkylene copolymer, polyglycerin-modified silicone Silicone-based nonionic surfactants such as corn and sugar-modified silicone; and cationic surfactants such as alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; Alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines such as stearamidepropyldimethylamine and stearamideethyldiethylamine and salts thereof; stearoxypropyldimethyl Alkyl ether amines such as amines and salts or quaternary salts thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyl dimethyl Fatty acid amide type quaternary ammonium salts such as ruammonium and ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and salts or quaternary salts thereof; alkylamine salts; fatty acid amidoguanidinium salts; Alkyltrialkylene glycol ammonium salt; Benzalkonium salt; Benzethonium salt; Pyridinium salt such as cetylpyridinium chloride; Imidazolinium salt; Alkylisoquinolinium salt; Dialkyl morpholinium salt; Polyamine fatty acid derivative; Aminopropyl dimethicone And amino-modified silicone such as amodimethicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone Cationic surfactants, etc .; in amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryl dimethylaminoacetic acid betaine); cocamidopropyl betaine, lauramidopropyl betaine, etc. Fatty acid amide alkyl-N, N-dimethylamino acid betaines; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate ester; Phosphate betaines such as ethanol phosphates; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, water Phospholipids such as raw-added soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants; Preferable examples include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymers, and various silicone surfactants.
When using a nonionic surfactant among these surfactants, avoid using a surfactant having many hydroxyl groups such as sorbitan and glycerin alone from the viewpoint of the stability of the formulation. It is preferable to use in combination with a polyoxyethylene alkyl ether surfactant or an ionic surfactant.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazoline derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzoyl chloride Luconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol , Photosensitizers, antibacterial zeolite, and silver ion are preferable, but when used as an antibacterial agent or antiseptic agent for antiseptic purposes, phenoxyethanol; 1 from the viewpoint of safety of cosmetics or skin external preparations; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.

  Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

  Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid-based UV absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone purple 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphsulfone Preference is given to acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

  Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbate phosphate and magnesium ascorbate phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylreso Shinoru, oil-soluble Kamomiraekisu, oil-soluble licorice extract, Nishikawa willow extract, be mentioned as saxifrage extract, and the like plant extracts are preferred.

  Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

  As plant / animal / microbe extracts, Iris extract, Ashitaba extract, Asunaro extract, Asparagus extract, Avocado extract, Achacha extract, Almond extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Ginkgo biloba extract, Ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.

As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Base dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4- hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-
phenylenediamine, HC Blue 2, Basic
Nitro dyes such as Blue 26; Disperse dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic red pigments such as iron oxide (Bengara) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Yellow oxidation Inorganic yellow pigments such as iron and ocher; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic such as chromium oxide, chromium hydroxide and cobalt titanate Green pigments; inorganic blue pigments such as ultramarine and bitumen; pearl pigments such as titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil; aluminum powder Metal powder pigments such as copper powder and gold; surface-treated inorganic and metal powder pigments; red 201, red 202, Color No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red 104 No., Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1, etc. Organic pigments such as zirconium, barium or aluminum lakes; surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin Naphthoquinones, bixins, flavones, betacyanidine, Natural pigments / dyes such as hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2 -Oxidative dye intermediates and couplers such as methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; auto-oxidizing dyes such as indoline; and dihydroxyacetone are preferred.

  Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  As the types of cosmetics or skin external preparations containing the diester composition of the present invention, skin external preparations such as hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, ointments and the like are preferable. As mentioned. The cosmetic / skin external preparation of the present invention can be produced according to a usual method.

  The cosmetic or skin external preparation containing the diester composition of the present invention will be described in more detail. Examples of the hair cosmetic include oil shampoo, cream shampoo, conditioning shampoo, dandruff shampoo, hair color shampoo, and rinse. Shampoo such as integrated shampoo; rinse, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream , Hair blow, split hair coat, hair oil, permanent wave agent, straight perm agent, oxidation hair dye, hair bleach, hair color pre-treatment, hair color after-treatment, perm pre- REIT instrument, perm after treatment, hair manicure, and the like as hair growth agents are preferred.

  Basic cosmetics include soft lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, nari Thing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, sun makeup cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; liposome Liposome cosmetics such as beauty essence and liposome lotion; Peel-off packs, powder packs, washing packs, oil packs, cleansing masks and other packs and masks; cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels, cleansing oils , Cleansing mask, washing powder, face washing powder, etc .; cosmetic soap, transparent soap, medicated soap, liquid soap, shaving soap, synthetic cosmetic soap Soap can be mentioned as preferred.

  Examples of makeup cosmetics that may be preferably used include white powder, dusts, foundations, lipsticks, lip gloss, blushers, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment.

  Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.

  Body cosmetics such as body shampoos; deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics; decoloring agents, hair removal / hair removal agents; bathing agents; insect repellents A repeller is preferred.

  Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

  The dosage forms of cosmetics or skin external preparations containing the diester composition of the present invention include oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W type. / O type emulsified cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gels Preferable examples include dosage forms such as cosmetics, pastes, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example, this invention is not limited to these Examples.

Synthesis example 1
In a 300 mL reactor equipped with a stirrer, a thermometer, and a gas inlet tube, 32.5 g (0.098 mol) of N-lauroyl-L-glutamic acid, 65.5 g (0.205 mol) of behenyl alcohol (manufactured by Cognis, STENOL 1822A) ), 60 g of toluene and 0.5 g of paratoluenesulfonic acid monohydrate were charged, heated to 110 to 123 ° C. under a nitrogen stream, and reacted for 8 hours while separating the distilled water. After cooling, unreacted carboxylic acid was washed away with an aqueous sodium hydroxide solution, and the solvent was distilled off under reduced pressure to obtain 91.8 g of dibehenyl N-lauroyl L-glutamate (yield 97%). The obtained diester was white waxy (acid value 0.1).

Synthesis example 2
In a 300 mL reactor equipped with a stirrer, a thermometer and a gas introduction tube, 27.9 g (0.084 mol) of N-lauroyl-L-glutamic acid, 71.9 g (0.176 mol) of phytosterol, 60 g of toluene, paratoluene 0.5 g of sulfonic acid monohydrate was charged, heated to 110 to 125 ° C. under a nitrogen stream, and reacted for 24 hours while separating the distilled water. After cooling, the unreacted carboxylic acid was washed away with an aqueous sodium hydroxide solution, and the solvent was distilled off under reduced pressure to obtain 82.3 g of diphytosteryl N-lauroyl L-glutamate (yield 85%). The obtained diester was a pale yellow highly viscous liquid (acid value 0.2).

Synthesis example 3
In a 300 mL reactor equipped with a stirrer, a thermometer, and a gas introduction tube, 31.6 g (0.095 mol) of N-lauroyl-L-glutamic acid, 59.6 g (0.199 mol) of 2-octyldodecanol, toluene 60 g and 0.5 g of paratoluenesulfonic acid monohydrate were charged, heated to 108 to 123 ° C. under a nitrogen stream, and reacted for 8 hours while separating the distilled water. After cooling, the unreacted carboxylic acid was washed away with an aqueous sodium hydroxide solution, and the solvent was distilled off under reduced pressure to obtain 83.9 g of di-2-octyldodecyl N-lauroyl L-glutamate (yield 96%). . The obtained diester was a pale yellow liquid (acid value 0.3).

Lamella formation ability About the diester obtained by the synthesis examples 1-3, and the mixture of each diester, the lamellar formation ability was evaluated using the polarizing microscope (an evaluation method is described below). The mixing ratio of each diester and the evaluation results are shown in Table 1.

<Evaluation method>
Each diester or a mixture of each diester was diluted to 50 w% with liquid paraffin, and 1 g of this diluted solution and 1 g of water were mixed in a mortar and allowed to contain water. A small amount of this hydrated substance was placed on a slide glass and sandwiched between cover glasses was observed with a polarizing microscope. An example of an observed polarization microscope image is shown in FIG. The lamella formation ability was evaluated in the following three stages based on the amount of observation of a Maltese cross image indicating the formation of lamella spherulites.

○: Many Maltese cross images are observed Δ: A few Maltese cross images are observed ×: No Maltese cross images are observed

  From the results shown in Table 1, the lamella forming ability was not confirmed in the diesters of Synthesis Examples 1 to 3 (behenyl alcohol, phytosterol, and 2-octyldodecanol each alone). On the other hand, lamella formation was found only in the mixture of Synthesis Example 1 and Synthesis Example 2, and it was found that this phenomenon depends on the mixing ratio.

  Next, the lamella formation ability was evaluated about the diester composition of N-lauroyl-L-glutamic acid and the mixed alcohol which consists of phytosterol and behenyl alcohol. In addition, the compound produced | generated by esterifying N-lauroyl-L-glutamic acid and the mixed alcohol which consists of phytosterol and behenyl alcohol is N-lauroyl-L-glutamate dibehenyl, N-lauroyl-L-glutamate diphytosteryl, N-lauroyl. 3 types of behenyl glutamate / phytosteryl and the resulting diester composition is a mixture of these compounds. The ratio of these three compounds in the diester composition is determined by the ratio of phytosterol and behenyl alcohol in the mixed alcohol used during the reaction.

  According to the method described in Synthesis Example 1, a diester composition was synthesized at the ratio of the mixed alcohol described in Table 2, and the lamella forming ability of the obtained diester composition was evaluated. The evaluation method is as described above, and the results are shown in Table 2. The melting point of the obtained diester composition is also shown. The melting point was measured using a differential scanning calorimeter (DSC-50, manufactured by Shimadzu Corporation), and was defined as the end temperature of melting of the obtained endothermic peak.

  From the results in Table 2, it was confirmed that the diester composition obtained had high lamella forming ability when the ratio of phytosterol to behenyl alcohol in the mixed alcohol (B / P) was in the range of 3-9.

  Next, the case where 2-octyldodecanol was further used as the mixed alcohol was examined. In this case, the diester composition includes N-lauroyl-L-glutamate dibehenyl, N-lauroyl-L-glutamate diphytosteryl, N-lauroyl-L-glutamate di-2-octyldodecyl, N-lauroyl-L-glutamate behenyl / phytosteryl. , N-lauroyl-L-glutamate behenyl / 2-octyldodecyl, N-lauroyl-L-glutamate phytostale / 2-octyldodecyl.

  According to the method described in Synthesis Example 1, a diester composition was synthesized at the ratio of the mixed alcohols described in Table 3, and the lamella forming ability of the obtained diester composition was evaluated. The results are shown in Table 2. The melting point of the obtained diester composition is also shown.

  From the results of Table 3, when the ratio of 2-octyldodecanol was 30 mol%, the lamella forming ability was not sufficient even when the ratio of phytosterol to behenyl alcohol (B / P) was 3 or more. On the other hand, when the ratio of 2-octyldodecanol was 20 mol% or less, it was confirmed that if the ratio of phytosterol to behenyl alcohol (B / P) was 3 or more, it had lamella forming ability.

Example 1, Comparative Examples 1 and 2
An emulsion having the formulation of Table 4 formulated with the diester composition of the present invention (the diester composition 9 of Table 3) was prepared (Example 1). For comparison, a diester composition deviating from the ratio of the present invention (diester composition 19 in Table 3) and an emulsion containing liquid paraffin were also prepared (Comparative Examples 1 and 2).

（調製方法）
Ｎｏ．１〜８を加え、約８０℃に加温し、溶解させた（Ａ部）。別容器にＮｏ．９〜１４、１６をとり、約８０℃に加温し、均一に溶解させた（Ｂ部）。Ａ部にＢ部を加え、ホモミキサーにて乳化させた後、Ｎｏ．１５を加え４０℃まで冷却した。

(Preparation method)
No. 1-8 was added, it heated at about 80 degreeC, and it was made to melt | dissolve (A part). No. in a separate container. 9-14 and 16 were taken and heated to about 80 ° C. and dissolved uniformly (part B). Add part B to part A and emulsify with a homomixer. 15 was added and cooled to 40 ° C.

Moisturizing / Skin Barrier Function Improvement Effect For the emulsion of Example 1 and the emulsions of Comparative Examples 1 and 2, the moisturizing / skin barrier function improving effect was evaluated using the stratum corneum water content and transepidermal water transpiration (TEWL) as indices. (The evaluation method is described below). The measurement result of the stratum corneum moisture content is shown in FIG. 2, and the measurement result of TEWL is shown in FIG.

<Evaluation method>
Each latex was applied twice a day for 4 weeks to the inner part of the human forearm of 10 panelists, and the amount of stratum corneum moisture and transepidermal water transpiration (TEWL) at the application site were measured. At the time of measurement, the measurement site was washed with hot water at 37 ° C. and acclimated for 30 minutes or more in an environment of 20 ° C. and humidity of 40%. The stratum corneum moisture content was measured using SKICON-200 manufactured by IBS, and TEWL was measured using TEWAMETER TM210 manufactured by Curage + Khazaka.

  From the results shown in FIG. 2, it was found that the emulsion containing the diester composition of the present invention has more stratum corneum water content than the comparative emulsion. From the results of FIG. 3, it was found that the emulsion containing the diester composition of the present invention had lower skin TEWL and improved skin barrier function than the comparison emulsion. That is, it was revealed that the diester composition of the present invention exhibits an excellent moisturizing / skin barrier function improving action. In addition, the diester composition used in Example 1 and the diester composition used in Comparative Example 1 are the same in the type of mixed alcohol and differ only in the ratio. The former has a lamellar forming ability, whereas the latter has a lamella. It has no ability to form. In view of this, it is considered that the above result is due to the action unique to the diester composition of the present invention, that is, lamella formation.

Example 2 Emulsion An emulsion having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Part A Diester composition of Table 3 9 2.00
Cetyl octanoate 5.00
Behenyl alcohol 2.00
Oleyl alcohol 0.50
Plandool-H (Nippon Seika) 0.50
Behenez-20 2.00
Steerless-20 1.00
Polyglyceryl pentaisostearate-10 0.50
Polyglyceryl laurate-10 0.50
Ethylparaben 0.20
Part B methylparaben 0.10
Phenoxyethanol 0.20
Citric acid 0.01
Sodium citrate 0.09
EDTA-2Na 0.10
(Eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 0.50
White jellyfish polysaccharide (Nippon Seika) 0.10
Purified water Total amount of 100 parts C xanthan gum (2%) 10.00
--------------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was heated to about 80 ° C. in a separate container and dissolved uniformly. After adding B part to A part and emulsifying with a homomixer, C part was added and it cooled to 40 degreeC.

Example 3 Emulsion An emulsion having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Part A Diester composition of Table 3 9 1.00
LUSPLAN PI-DA (Nippon Seika) 1.00
Cetanol 0.20
Squalane 0.50
Soybean oil 0.50
Behenez-30 0.50
Colles-30 1.00
Ethylhexyl methoxycinnamate 0.05
Tocopherol 0.05
Part B stearoxyhydroxypropylmethylcellulose 0.40
Purified water 20.00
Part C 3-O-ethylascorbic acid 1.00
Arbutin 2.00
Purified water 5.00
D part cyclohexanedicarboxylic acid bisethoxydiglycol 0.50
HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.01
Hyaluronic acid Na 0.03
Sorbitol 6.00
Succinic acid 0.03
Sodium succinate proper amount diglycerin 1.50
Sohakuhi extract 0.20
Loquat leaf extract 0.15
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was dissolved uniformly. Part D was heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and cooled to 40 degreeC.

Example 4 Emollient Cream An emollient cream having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Part A Diester composition of Table 3 9 2.00
Macadamia nut oil fatty acid phytosteryl 2.00
Hydrogenated palm oil 2.50
Behenyl alcohol 2.00
Dimethicone (10cs) 1.50
Glyceryl stearate 1.50
Stearyl alcohol 1.20
Stearic acid PG (SE) 1.00
PEG-60 glyceryl isostearate 1.00
Octyl methoxycinnamate 0.20
Ethylparaben 0.10
Part B 1,3-butylene glycol 6.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was heated to about 80 ° C. in a separate container and dissolved uniformly. Part B was added to part A, emulsified with a homomixer, and then cooled to 40 ° C.

Example 5 Lotion Toner lotion having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Part A Table 3 Diester Composition 9 0.02
Hydrogenated lecithin 0.30
PEG-60 hydrogenated castor oil 0.10
Phytosterol 0.02
1,3-butylene glycol 6.00
1,2-pentanediol 2.00
Glycerin 2.00
Part B Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was heated to about 80 ° C. in a separate container and dissolved uniformly. Part B was added to part A, emulsified with a homomixer, and then cooled to 40 ° C.

Example 6 Sunscreen Using the diester composition of the present invention, a sunscreen having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------------
Part A quaternium-18 hectorite 1.00
Part B Diester composition of Table 3 9 2.00
Cyclomethicone 13.70
Diphenyl dimethicone 7.00
Dimethicone copolyol 5.50
Part C silicone-treated fine particle titanium oxide 3.90
Silicone-treated zinc oxide 2.10
D part Al stearate 0.70
Hydroxide Al 0.50
Isononyl isononanoate 2.50
Isodecyl neopentanoate 1.50
Neosolue-DE (Nippon Seika) 1.00
Part E Trimethylsiloxysilicate 1.20
Dimethicone 0.80
Meticon 0.10
Stearyl glycyrrhetinate 0.02
Sorbitan sesquioleate 2.00
Tocopherol 0.02
Part F Na chloride 1.00
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Production method)
Add Part A to Part B and stir. Further, part C was added and dispersed using a roller mill. Part D was heated and melted, added to the mixture of A, B, and C, and further part E was added to about 70 ° C. Part F was heated, gradually added to the mixture of A to E with stirring and emulsified, and then cooled to 40 ° C. with stirring.

Example 7 Cleansing Milk Cleansing milk having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Part A Diester composition of Table 3 9 2.00
Neosolute-MP (Nippon Seika) 8.00
Plandool-G (Nippon Seika) 1.00
Diethylhexyl sebacate 1.00
Stearic acid 0.50
Mineral oil 29.00
Triceteth-5-phosphate 2.40
Stearic acid PG (SE) 3.60
Dimethicone 10.00
Propylparaben 0.10
Part B EDTA-2Na 0.05
Methylparaben 0.15
Phenoxyethanol 0.20
Purified water Total amount of 100 parts C carbomer (2%) 10.00
--------------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was heated to about 80 ° C. in a separate container and dissolved uniformly. After adding B part to A part and emulsifying with a homomixer, C part was added and it cooled to 40 degreeC.

Example 8 Body Shampoo A body shampoo having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Diester composition of Table 3 9 0.50
Cocoyl Methyl Taurine Na 10.00
Lauroyl hydrolyzed silk Na 6.00
Lauroylmethylalanine Na 10.00
Cocoamphoacetate Na (30%) 4.00
Cocamidopropyl betaine (30%) 10.00
Cocamide DEA 3.00
1,3-butylene glycol 5.00
Methylparaben 0.20
Purified water Total amount of 100 --------------------------------------
(Production method)
All components were heated at about 80 ° C. and stirred and mixed uniformly.

Example 9 Lipstick A lipstick having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Part A Table 3 Diester Composition 9 15.00
Triethylhexanoin 20.00
Cetyl ethylhexanoate 15.00
Cyclomethicone 16.00
Jojoba oil 1.00
Ceresin 9.00
Candelilla wax 5.00
Sorbitan sesquiisostearate 4.00
Dextrin palmitate 1.00
Tocopherol 0.50
Part B LUSPLAN DD-DA7 (Nippon Seika) 7.00
Iron oxide 2.25
Mica 1.50
Titanium oxide 2.25
Red 202 1.50
--------------------------------------
(Preparation method)
Part A was heated to about 100 to 110 ° C. and dissolved uniformly. Next, part B was added and mixed with a roll mill. Part A and part B were added, heated to about 80 ° C., uniformly stirred and mixed, then filled into a mold and rapidly cooled.

Example 10 Lip Gloss A lip gloss having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Diester composition of Table 3 9 55.00
LUSPLAN DD-DA7 (Nippon Seika) 15.00
Polyethylene wax 0.20
12-hydroxystearic acid 1.50
Tocopherol Appropriate amount Liquid paraffin Amount to be 100 in total Part B Silylated ultrafine silica 2.00
(Aerosil R972 manufactured by Nippon Aerosil Co., Ltd.)
Mica titanium 12.00
--------------------------------------
(Preparation method)
After all the ingredients were uniformly heated and mixed, part B was added and mixed uniformly.

Example 11 Foundation A foundation having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Diester composition of Table 3 9 1.00
Plandool-S (Nippon Seika) 5.00
Cyclomethicone 3.50
Dimethicone (5cs) 2.00
Trimethylsiloxysilicate 1.50
Octyl methoxycinnamate 1.00
Phenoxyethanol 0.40
Tocopherol 0.10
Mica 39.60
Talc 24.00
Titanium oxide 20.00
Iron oxide 1.90
--------------------------------------
(Preparation method)
All ingredients were stirred at high speed and mixed uniformly.

Example 12 Shampoo A shampoo having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Part A Diester composition of Table 3 9 0.50
Cocoyl Methyl Taurine Na (30%) 15.00
Cocamidopropyl betaine (30%) 15.00
Cocoa glutamate TEA (30%) 15.00
Laureth-12 Na acetate (30%) 5.00
1,3-butylene glycol 1.00
Cocamide MEA 2.00
Cationic NH (Nippon Seika) 0.50
Glycol distearate 1.50
PEG-150 stearate 1.00
Part B Polyquaternium-10 0.50
Polyquaternium-7 0.30
Sodium benzoate 0.20
Etidronic acid 0.10
Phenoxyethanol 0.20
Methylparaben 0.20
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. In a separate container, part B was heated to about 80 ° C. and dissolved. While stirring Part B into Part A, they were gradually added and mixed uniformly, and then rapidly cooled.

Example 13 Treatment A treatment having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Part A Diester composition of Table 3 9 0.50
Neosole-Aquilio (Nihon Seika) 0.50
Glyceryl stearate (SE) 4.50
Steerless-10 4.00
Cetanol 4.00
Steartrimonium chloride (63%) 1.80
Hydrolyzed keratin (20%) 1.50
Behentrimonium chloride (80%) 1.00
B part methyl paraben 0.20
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. In a separate container, part B was heated to about 80 ° C. and dissolved. While stirring Part A to Part B, it was gradually added and mixed uniformly.

Example 14 Hair mist A hair mist having the following formulation was prepared using the diester composition of the present invention.

Component Blending amount (% by weight)
--------------------------------------
Part A Table 3 Diester Composition 9 0.02
Distearyldimonium chloride 0.20
Behentrimonium chloride 0.02
Phytosterol 0.01
γ-ercalactone 0.01
Polyglyceryl oleate-10 0.50
1,3-propanediol 1.00
Purified water 10.00
Part B Polyquaternium-6 0.50
(Alkyl acrylate / diacetone acrylamide)
Copolymer AMP 0.02
Lactic acid Na 0.01
Betaine 0.02
PPG-6 decyltetradeces-30 0.02
Ethanol 10.0
Methylparaben 0.20
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and emulsified with a homomixer. In a separate container, part B was heated to about 80 ° C. and dissolved. While stirring Part A to Part B, it was gradually added and mixed uniformly.

Polarized light microscope image of diester composition 9 Measurement results of stratum corneum moisture content Measurement result of transepidermal water transpiration (TEWL)

Claims (3)

And N- lauroyl -L- glutamic acid, the diester composition of the mixed alcohols consisting of phytosterols and behenyl alcohol, Ri molar ratio 3-9 der behenyl alcohol for phytosterols, upon mixing the diester composition and water, the A diester composition for cosmetics or an external preparation for skin, characterized by forming a lamellar structure with two components of a diester composition and water .   The diester composition according to claim 1, further comprising 2-octyldodecanol as the mixed alcohol, wherein the content of 2-octyldodecanol is 20 mol% or less in the mixed alcohol. Cosmetics or skin external preparation containing the diester composition of Claim 1 or 2 .

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