JP4815164B2 - Moisturizer and cosmetic and skin external preparations containing the same - Google Patents

Description

The present invention relates to a moisturizing agent containing an oligomer ester excellent in moisturizing property, and a cosmetic and an external preparation for skin containing these, excluding a hair styling agent. More specifically, the weight of one or more divalent carboxylic acids containing a straight chain, branched chain, or cyclic structure having 8 to 44 carbon atoms and a polyalkylene glycol having a number average molecular weight of 285 to 10,000. A moisturizer excellent in safety, touch and the like, characterized by containing an oligomeric ester having an average molecular weight of less than 50,000, and
The present invention relates to cosmetics and skin external preparations containing these, excluding hairdressing agents.

In general, skin dryness is likely to occur when the stratum corneum barrier function is lowered due to a decrease in lipids between keratinocytes such as ceramide and cholesterol, and transepidermal water loss is increased. Especially in winter,
A state in which the dryness of the skin deteriorates due to excessive skin washing, age, constitutional decrease in lipids between keratinocytes, etc., and the moisture content of the horny layer decreases to about 10% or less is called dry skin. When such a skin is dry, the skin becomes dull and causes problems such as fine lines.
Conventionally, various methods have been proposed to improve these dry skin conditions. For example, a method of suppressing transepidermal water loss using an occlusive agent such as petrolatum or water-in-oil emulsion, which has good adhesion to the skin and high hydrophobicity; glycerin and pyrrolidone carboxylic acid having hygroscopic and moisturizing properties A method of enhancing the hydration effect using salts, amino acids, peptides, hyaluronate, etc .; and a method of blending ceramide, sphingolipid, and the like, which are components of intercellular lipids, have been proposed. (See Patent Documents 1 and 2).
However, none of the methods known in the prior art have sufficient water retention ability, and particularly when using a highly hydrophobic water-insoluble occlusive agent or oil, it is oily and sticky. There were drawbacks that gave an unpleasant feel. On the other hand, in the case of using a water-soluble moisture absorbent and humectant, in order to enhance the effect, a large amount of these must be blended, resulting in a problem of giving an unpleasant feel such as stickiness. There was a drawback.
JP-A-61-37710 Japanese Patent Publication No. 6-57651

On the other hand, as an oligomer ester of polyvalent carboxylic acid and polyalkylene glycol, it has been conventionally proposed as a hair fixing agent (see Patent Document 3). In addition, hair styling agents containing these have been proposed (see Patent Documents 4 and 5). The oligomer esters described in these are for fixing the hair by forming a high-strength film on the hair, and the condition is that the oligomer ester should have a weight average molecular weight of 10,000 or more, or 50,000 or more. There is. However, such an oligomer ester that forms a high-strength film, when used in cosmetics or skin external preparations other than hair styling agents, impairs a good feeling of use and does not give an excellent feel. .
Japanese Examined Patent Publication No. 6-27053 Japanese Patent No. 3447833 Japanese Patent No. 3545491

Therefore, the problem to be solved by the present invention is to moisturize with sufficient moisture retention, have few problems in touch, and have a high safety moisturizer, and hair styling containing these. It is to provide cosmetics and skin external preparations excluding the preparation.

As a result of intensive studies to solve the above problems, the inventors of the present invention have one or more divalent carboxylic acids containing a linear, branched, or cyclic structure having 8 to 44 carbon atoms, and a number average molecular weight. 285-
It has been found that an oligomeric ester having a weight average molecular weight of less than 50,000 with 10,000 polyalkylene glycol has a high moisturizing effect due to sufficient moisture retention, and has no problem in touch and safety. . The present invention has been completed based on the above findings.
That is, the present invention provides a weight of one or more divalent carboxylic acids containing a linear, branched or cyclic structure having 8 to 44 carbon atoms and a polyalkylene glycol having a number average molecular weight of 285 to 10,000. A humectant comprising an oligomeric ester having an average molecular weight of less than 50,000,
In addition, the present invention provides cosmetics and skin external preparations excluding hairdressing agents containing the same.

The oligomer ester contained in the moisturizing agent of the present invention moisturizes with sufficient moisture retention, has few problems in touch and is highly safe, and a cosmetic containing this In addition, the external preparation for skin has a high moisturizing function and is excellent in touch and safety.

（１）
（式中、Ｒ１は炭素数６〜４２の直鎖または分岐鎖、若しくは環状構造を含む炭化水素基
である）
具体的には、スベリン酸、アゼライン酸、セバシン酸、２，４−ジエチルペンタン二酸、
ウンデカン二酸、ドデカン二酸、トリデカン二酸、テトラデカン二酸、ペンタデカン二酸
、ヘキサデカン二酸、オクタデカン二酸、エイコサン二酸、ジメチルエイコサン二酸、シ
クロヘキサンジカルボン酸、ダイマー酸、水添ダイマー酸等を例示することができる。
これら二価のカルボン酸の中でも、得られるオリゴマーエステルの化粧料に用いた時の感
触等の点から、特に、シクロヘキサンジカルボン酸、水添ダイマー酸のような分子内に環
状構造を含む二価カルボン酸が好ましい。 As 1 type, or 2 or more types of bivalent carboxylic acid used for manufacture of the oligomer ester contained in the moisturizing agent of this invention, it is represented by following Chemical formula (1),

(1)
(In the formula, R1 is a hydrocarbon group containing a linear or branched chain having 6 to 42 carbon atoms or a cyclic structure)
Specifically, suberic acid, azelaic acid, sebacic acid, 2,4-diethylpentanedioic acid,
Undecanedioic acid, dodecanedioic acid, tridecanedioic acid, tetradecanedioic acid, pentadecanedioic acid, hexadecanedioic acid, octadecanedioic acid, eicosandioic acid, dimethyleicosandioic acid, cyclohexanedicarboxylic acid, dimer acid, hydrogenated dimer acid, etc. Can be illustrated.
Among these divalent carboxylic acids, divalent carboxylic acids containing a cyclic structure in the molecule such as cyclohexanedicarboxylic acid and hydrogenated dimer acid, in particular, from the viewpoint of touch when used in cosmetics of the resulting oligomeric ester. Acid is preferred.

Among these, dimer acid is a known dibasic acid obtained by an intermolecular polymerization reaction of unsaturated fatty acid, and its industrial production process is almost standardized in the industry. For example, dimer acid is obtained by dimerizing an unsaturated fatty acid having 11 to 22 carbon atoms with a clay catalyst or the like. The dimer acid obtained industrially is mainly composed of a dibasic acid (dimer) having about 36 carbon atoms, but contains an arbitrary amount of trimer and monomer depending on the degree of purification. In general, the dimer content is 7
There are products in excess of 0% by weight and those in which the dimer content is increased to 90% or more by molecular distillation. In addition, although a double bond remains after the dimerization reaction, a dimer acid that is further hydrogenated to improve oxidation stability, that is, a hydrogenated dimer acid, is also on the market. Any dimer acid currently in circulation can be used in the present invention, but hydrogenated dimer acid is more preferable from the viewpoint of oxidation stability. Examples of such dimer acid include PRIKOL 1006, 1009, and 10 of Unikema Corporation.
15 and 1025 are commercially available.

Cyclohexanedicarboxylic acid is not limited in its production method, but is generally a dibasic acid obtained by hydrogenating phthalic acid, isophthalic acid, or terephthalic acid, and 1,2-cyclohexanedicarboxylic acid, 1 , 3-cyclohexanedicarboxylic acid, 1,4-cyclohexanedicarboxylic acid. Furthermore, there are cis and trans isomers, respectively. Any of these six isomers may be used in the present invention, and a mixture of two or more of these may be used, but cis / trans mixed 1,4-cyclohexanedicarboxylic acid is generally used. Is. As such cyclohexanedicarboxylic acid, for example, 1,4-CHDA manufactured by Eastman Chemical Co., Ltd. is commercially available.

Examples of the polyalkylene glycol used for the production of the oligomer ester contained in the humectant of the present invention include polyethylene glycol, polypropylene glycol, polybutylene glycol, and ethylene glycol / propylene glycol copolymer. Furthermore, in order to retain high moisture retention in the oligomer ester, it is preferable to include an ethylene chain in the alkylene chain, more preferably a polyethylene glycol, an ethylene glycol / propylene glycol copolymer, and particularly preferably polyethylene glycol. .
In order to further improve the moisture retention of the oligomer ester, the polyalkylene glycol preferably has a number average molecular weight of 285 or more. On the other hand, when the oligomer ester forms a high-strength film, the usability is impaired, so that the weight average molecular weight when oligomerized is less than 50,000 is preferable. The number average molecular weight is preferably 10,000 or less. More preferably, the weight average molecular weight when oligomerized is less than 10,000, and therefore the number average molecular weight of the polyalkylene glycol is more preferably 3000 or less. From the above, the present invention has a number average molecular weight of 28.
5 to 10,000 polyalkylene glycols are preferred, especially the number average molecular weight is 285 to 300.
More preferred is zero polyalkylene glycol.

Although the manufacturing method of the oligomer ester of 1 type, or 2 or more types of bivalent carboxylic acid and polyalkylene glycol contained in the moisturizer of this invention is not specifically limited, For example, 1 type or 2 types or more of 2 types It can be obtained by an esterification reaction of a valent carboxylic acid and a polyalkylene glycol. In the production of these esters, the weight average molecular weight of the resulting oligomer ester can be adjusted by changing the respective charging ratios of the divalent carboxylic acid and the polyalkylene glycol. The range of the charging ratio is 0.2 to 1.0 molar equivalent of divalent carboxylic acid with respect to 1 molar equivalent of polyalkylene glycol, and the reaction rate at the time of esterification and the weight average molecular weight of the resulting ester are considered. Then, a more preferable range of the charging ratio is such that the divalent carboxylic acid is 0.1% relative to 1 molar equivalent of the polyalkylene glycol.
4 to 0.8 molar equivalent. The oligomer ester thus obtained can be used as it is as a moisturizing agent or in cosmetics and external preparations for skin, but it can be further purified and used by a usual method if necessary.

The conditions for the esterification reaction are not particularly limited, and the reaction is performed by a commonly used method. For example, the reaction can be performed at 50 to 260 ° C. using paratoluenesulfonic acid, sulfuric acid, hydrochloric acid, methanesulfonic acid, boron trifluoride diethyl ether complex or the like as a catalyst and toluene, xylene or the like as a solvent. Alternatively, the esterification can be carried out at 150 to 260 ° C. even without solvent and without catalyst.

The oligomer ester obtained as described above is effective as a skin moisturizer because it has sufficient moisture retention and high moisturizing effect while having properties as an oil agent, and there is no problem in touch and safety. It is. The moisturizing agent of the present invention contains the present oligomer ester, but is generally blended in cosmetics and skin external preparations to be described later in addition to the present oligomer ester within a range that does not impair the preferable effects of the present invention. Ingredients may be blended. Although the compounding quantity to the moisturizer of the oligomer ester of this invention is not specifically limited, About 10 to 100 weight% is preferable, More preferably, it is 30 to 100 weight%.
On the other hand, cosmetics and skin external preparations containing the moisturizing agent of the present invention have a high moisturizing function and are excellent in touch and safety due to the effect of the moisturizing agent of the present invention. The blending amount of the moisturizing agent of the present invention into the cosmetic and the external preparation for skin is not particularly limited, but is preferably about 0.01 to 60% by weight, more preferably 0.05 to 40% by weight as the oligomer ester. Further, in the cosmetic and skin external preparation of the present invention, water and additive components generally incorporated in the cosmetic and skin external preparation as necessary, for example, an oily base, a moisturizer, a touch improver, a surface activity Agent, polymer, thickening / gelling agent, solvent, propellant, antioxidant, reducing agent, oxidizing agent, preservative, antibacterial agent, chelating agent, pH adjuster, acid, alkali, powder, inorganic salt, UV absorbers, whitening agents, vitamins and derivatives thereof, anti-inflammatory agents, anti-inflammatory agents, hair-restoring agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, squeeze agents, cooling agents, Warming sensation agent, wound healing promoter, stimulation relieving agent, analgesic agent, cell activator,
Plant / animal / microbe extracts, antipruritics, exfoliating / dissolving agents, antiperspirants, refreshing agents, astringents, enzymes, nucleic acids, fragrances, pigments, colorants, dyes, pigments, water, and the like can be added.

Examples of these additive components include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, seraalkyl alcohol, batyl. Higher alcohols such as alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylen Acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, ethyl Higher fatty acids such as cosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, and hydrogenated dimer acid, and metals such as aluminum salts, calcium salts, magnesium salts, zinc salts, and potassium salts Soaps and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene,
Hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene,
Carbides such as petrolatum, solid paraffin; candelilla wax, carnauba wax,
Waxes such as rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene propylene copolymer;
Palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil , Persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated coconut oil, hydrogenated Vegetable oils such as castor oil, jojoba oil, hydrogenated jojoba oil; animal fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; animals such as whale wax, lanolin, orange luffy oil Waxes: liquid lanolin, reduced lanolin, adsorbed purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene Lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, lanolin such as acetic acid (cetyl lanolyl) ester; sphingo such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin Phospholipids such as phospholipid, phosphatidic acid, lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid; cholesterol, dihydrocholesterol, Sterols such as lanosterol, dihydrolanosterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, nonanoate Steryl, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N- lauroyl -
L-glutamate di (cholesteryl / behenyl / octyldodecyl), N-lauroyl-
L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N-lauroyl sarcosine isopropyl, etc. Acyl sarcosine alkyl ester, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl, etc. Sterol esters: Lipid complexes such as phospholipid / cholesterol complex, phospholipid / phytosterol complex Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl paritate, octyldodecyl palmitate, cetyl octanoate, hexyl decyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate Isodecyl acid, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate,
Octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isostearic acid Monoalcohol carboxylates such as isopropyl, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate; cetyl lactate, Oxyacid esters such as diisostearyl malate and hydrogenated castor oil monoisostearate; Glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic acid / capric acid), tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester) Gum), rosin triglyceride (ester gum),
Glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, diolein Propylene glycol acid, pentaerythrityl tetraoctanoate,
Hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate,
(Isostearic acid / sebacic acid) ditrimethylolpropane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate,
Nonaisostearic acid polyglyceryl-10, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyl decanoic acid / sebacic acid) diglyceryl oligoester, polysuccinic acid fatty acid ester such as glycol distearate (ethylene glycol distearate) Dimer dimerolinolate diisopropyl, dimer dilinoleate diisostearyl, dimer dilinoleate di (isostearyl / phytosteryl),
Dimer dilinoleic acid (phytosteryl / behenyl), dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearate dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin Condensates, dimer linoleic acid hydrogenated castor oil, dimer acid or dimer diol derivative such as hydroxyalkyl dimer linoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DE)
A), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MI)
PA), fatty acid alkanolamides such as palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane)
, Highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) ) Copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicone such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, Carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone Corn, alkyl ether modified silicone, amino acid modified silicone, peptide modified silicone, fluorine modified silicone, cation modified and polyether modified silicone, amino modified and polyether modified silicone, alkyl modified and polyether modified silicone, polysiloxane / oxyalkylene copolymer Preferred examples include silicones such as coalescence; fluorine oils such as perfluorodecane, perfluorooctane, and perfluoropolyether.

As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. Le acids; sorbitol, xylitol, erythritol,
Sugar alcohols such as mannitol and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α -, Β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl Sugars such as glucoside, glucosylethyl methacrylate polymer or copolymer, and derivatives thereof; hyaluronic acid, sodium hyaluronate; chondroitin sulfate sodium; Itine sulfate, caronine sulfate, keratosulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally-occurring polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone −
5-Carboxylic acid and its sodium salts; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid Amino acids such as cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and salts thereof; collagen,
Fish-derived collagen, atelocollagen, gelatin, elastin, collagen degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzing keratin, conchiolin degrading peptide, hydrolyzing conchiolin, silk proteolytic peptide Hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide, acylated peptide and other protein peptides and derivatives thereof; palmitoyl oligopeptide, palmitoyl pentapeptide, Acylated peptides such as palmitoyl tetrapeptide; Silylated peptides; Lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypo Urine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerustin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Animal and plant extract ingredients such as Izayoi rose extract, Achillea millefolium extract, Eucalyptus extract, Merirot extract, natural ceramide (types 1, 2, 3, 4,
5,6), ceramides such as hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide and sugar-ceramide-containing extract are preferred.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB.
Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium minate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonate; alkylsulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and tetraethanolamine tetraethanol; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laurethrin Alkyl ether phosphates such as sodium, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide ether phosphorus Acid salts; phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone;
Nonionic surfactants include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), isosteares (
Polyoxyethylene isostearyl ether), octyldecesses (polyoxyethylene octyldodecyl ether) and other polyoxyethylene addition polyoxyethylene alkyl ethers; polyoxyethylene alkylphenyl ethers; polyoxyethylene hydrogenated castor oil, Polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid Castor oil and hardened castor oil derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; Lenlanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene water Lanolin, polyoxyethylene / polyoxypropylene alkyl ether such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; stearin Glyceryl acid, glyceryl isostearate, glyceryl palmitate,
Glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, α, α'-
Glycerin fatty acid partial esters such as glyceryl oleate, glyceryl monostearate, and malic acid monostearate; polyglyceryl stearate-2, 3, 4, 5, 6, 8, 8, 10, polyglyceryl-6 distearate, 10, polyglyceryl tristearate-2, polyglyceryl-10 decastearate, polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 8, diisostearate polyglyceryl-2 (diisostearate di Glyceryl), 3, 10, 10, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 4, 5, 6, 8 10, dioleic acid polygly Polyglycerin fatty acid esters such as ril-6, polyglyceryl-2 trioleate, and polyglyceryl-10 decaoleate; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; penta Erythritol partial fatty acid ester; sorbitol partial fatty acid ester; maltitol partial fatty acid ester;
Maltitol ether; sorbitan monooleate, sorbitan monoisostearate,
Sorbitan fatty acid esters such as sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; Sugar fatty acid ester, methyl glucoside fatty acid ester, sugar derivative partial ester such as undecylenic acid trehalose; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; lanolin alcohol; reduced lanolin;
Polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate; polyoxyethylene / propylene glycol fatty acid ester; polyoxyethylene Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxyethylene Sorbitan monostearate,
Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate and polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene Polyoxyethylene sorbitol fatty acid ester such as sorbitol monostearate; Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; Isostearyl glyceryl ether, Kimyl Alkyl glyceryl ethers such as alcohol, ceralkyl alcohol and batyl alcohol; Polyhydroxyalkylene alkylamines; Polyoxyethylene alkylamines; Tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; Natural surfactants such as saponins and sophorolipids; Polyoxyethylene fatty acid amides; Cocamide MEA), palm oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA)
), Lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide M)
EA), fatty acid alkanolamides such as palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); alkyldimethylamines such as lauramine oxide, cocamamine oxide, stearamine oxide, behenamine oxide Oxides; alkylethoxydimethylamine oxides; polyoxyethylene alkyl mercaptans; polyether-modified silicones such as dimethicone copolyols, silicone-based nonionic surfactants such as polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones Agents, etc .;
Cationic surfactants include behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride and other alkyltrimethylammonium chlorides; stearyltrimonium bromide and other alkyltrimethylammonium bromides; distearyldimonium chloride, Dialkyldimethylammonium chlorides such as dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl etheramines such as stearoxypropyldimethylamine and salts or quaternary salts thereof; Chain-branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl sulfate lanolin fatty acid aminopropylethyldi Fatty acid amide type quaternary ammonium salts such as tilammonium; polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; Silicone-based cationic surfactants such as modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone;
For amphoteric surfactants, N such as lauryl betaine (lauryl dimethylaminoacetic acid betaine)
-Alkyl-N, N-dimethylamino acid betaine; fatty acid amide alkyl such as cocamidopropyl betaine and lauramidopropyl betaine; N, N-dimethylamino acid betaine; imidazoline type betaine such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyldimethyltaurine Alkylsulfobetaines such as alkyl dimethylaminoethanol sulfates; phosphate betaines such as alkyldimethylaminoethanol phosphates; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin; lysolecithin , Hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, hydroxylated lecithin, etc. Phospholipids; silicone amphoteric surfactants;
Among the polymeric surfactants, polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymer; various silicone surfactants are preferable.

Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, Chitin, chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypro Cellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder and derivatives thereof; soluble starch, carboxymethyl starch, methylhydroxypropyl starch , Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, corn starch succinate corn starch, and alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP) , Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ester Ter; polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymers; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; poly Acrylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride ・ acrylamide copolymer, acrylic acid ・
Cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as polyquaternium-47, chloromethacrylic acid choline ester Polymers; Cationic polysaccharides such as cationized oligosaccharides, cationized dextran, guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymers; polymers of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and butyl methacrylate Copolymers with polymers, etc .; acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber And polymer emulsions such as synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxy Stearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, fumed silica (ultrafine silicic anhydride), magnesium aluminum silicate, magnesium magnesium silicate, metal soap, dialkyl phosphoric acid Preferable examples include metal salts, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters.

Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol)
, Lower alcohols such as butanol and isobutyl alcohol; propylene glycol, 1
, 3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyldiol, and other glycols; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl Glycol ethers such as ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Die succinate Kishiechiru, glycol esters such as ethylene glycol disuccinate; benzyl alcohol, benzyloxy ethanol, propylene carbonate,
Preferred examples of the propellant include dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; LPG, dimethyl ether, and carbon dioxide.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (
Ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; Glycerol, thiourea, thioglycolic acid, and cysteine hydrochloride are preferred. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

Preservatives and antibacterial agents include hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben, and butylparaben and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-pentanediol, 1,2-hexane 1,2-diols such as diols; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts;
Phenols: Halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol Preferred phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolite, and silver ion. Chelating agents include EDTA and E
Edetate (ethylenediaminetetraacetate) such as DTA2Na, EDTA3Na, EDTA4Na; Hydroxyethylethylenediaminetriacetate such as HEDTA3Na; Pentate (diethylenetriaminepentaacetate); Phytic acid; Phosphonic acid such as etidronate and its sodium salt Sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, Succinic acid and tartaric acid are preferred. Examples of pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid,
Succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid,
Monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, Sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium,
Zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite,
Hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud,
Metal soap (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide , Fine particles and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and hydrophobized or treated with various surface treatment agents such as silicones such as hydrogen silicone and cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powder such as hydrophilized powder;
Starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, benzoguanamine resin powder, polyethylene terephthalate / polymethyl methacrylate laminated powder,
Preferred are organic powders and surface-treated powders and organic-inorganic composite powders of various sizes and shapes such as polyethylene terephthalate / aluminum / epoxy laminated powder, urethane powder, silicone powder, Teflon (registered trademark) powder, etc. Can be mentioned. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates,
Preferred examples include potassium phosphates, calcium phosphates, and magnesium phosphates.

Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Linear absorption agents; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4
Diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-
p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano- β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine)
, Cinnamic acid UV absorbers such as glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,
2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4
'-Dimethoxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy -4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4
Benzophenone ultraviolet absorbers such as' -phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3- (4'-methylbenzylidene) -d , L-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2
'-Hydroxy-5-methylphenylbenzotriazole; 2- (2'-hydroxy-5
'-T-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole;dibenzalazine;dianisoylmethane; 5- (3,3-
Dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- ( 2′-hydroxy-5′-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, 2-methoxyhexyl dimethoxybenzylidenedioxoimidazolidinepropionate, etc. Hydantoin derivatives, phenylbenzimidazolazolesulfonic acid, terephthalylidene dicamphulsulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and derivatives thereof, oryzanol and derivatives thereof are preferable.

Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbate phosphate and magnesium ascorbate phosphate, ascorbic acid Ascorbic acid fatty acid ester such as tetraisopalmitic acid ester, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and its fatty acid esters, ascorbic acid sulfate,
Ascorbic acid derivatives such as tocopheryl phosphate ascorbyl; kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, Nishikawa Plant extracts such as willow extract and yukinoshita extract are preferred.

Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid ,
Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and derivatives such as nicotinic tocopherol / tocopherol acetate, γ-oryzanol, nicotinic acid and nicotinic acid amide / nicotinic acid benzyl ester Derivatives such as inositol hexanicotinate and nicotine alcohol, allantoin, photosensitive element 301, photosensitive element 401, capronium chloride, pentadecanoic acid monoglyceride, flavonol derivative, stigmasterol or stigmasteranol and its glycoside, and minoxidil are preferred. Can be mentioned. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Anti-wrinkle agent,
Other medicinal agents such as anti-aging agents, squeezing agents, cooling sensations, warming sensations, wound healing promoters, irritation relievers, analgesics, cell activators, etc. include retinols, retinoic acids, tocopheryl retinoic acid; lactic acid , Glycolic acid, gluconic acid, fruit acid, salicylic acid and derivatives thereof such as glycosides and esterified products, α- or β-hydroxy acids such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl, etc. And derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene, astaxanthin, α-lipo Antioxidants and active oxygen scavengers such as acids; catechins; flavones such as quercetin; Soflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; Licorice extract-related substances such as glabrizine, glabrene, liquiritin, isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol and derivatives thereof; capsaicin, vanillin, etc. and derivatives; insect repellents such as diethyltoluamide; A complex of a physiologically active substance and cyclodextrins is preferable.

Plant / animal / microbe extracts include iris extract, ashitaba extract, asunalo extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Torque, Kakkonekisu, Kamomiraekisu, oil-soluble Kamomiraekisu, Carrot extract, Kawarayomogiekisu, oat extract, Karukadeekisu,
Licorice extract, oil-soluble licorice extract, kiwi extract, kiou extract, jellyfish extract, quina extract, cucumber extract, giraffe leaf extract, guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis Extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, black pepper extract, black tea extract, yeast extract, yeast extract, coffee extract, burdock extract, rice extract, rice fermentation extract, rice fermented rice extract, rice Germ oil, Comfrey extract, Collagen, Cowberry extract, Saisin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract,
Soap extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract,
Shiitake extract, Giant extract, Shikon extract, Perilla extract, Shinobi extract, Shimotake extract, Jatoba extract, Peonies extract, Ginger extract, Ginger root extract, Birch extract, White jellyfish extract, Horsetail extract, Stevia extract, Stevia fermented product, Nishikawa willow extract, Kizota Extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, nematode extract, sensu extract, perennial extract, dairy extract, soybean extract, tiso extract, thyme extract, dandelion extract, lichen extract , Tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, strawberry tea extract, red pepper extract, toki extract, Lauren extract, Spruce extract, Spruce extract, Dokudami extract, Tomato extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bacmond extract, Lotus extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Parietaria extract , Toad extract, bisabolol, hinoki extract, bifidobacteria extract, loquat extract, dandelion extract, burdock extract, butterfly extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, bodaiju extract, button Extract, hop extract, mica squid extract, pine extract, marronnier extract, mizubasho extract, mukuroji extract, melissa extract, moss Extract, Peach Extract, Cornflower Extract, Eucalyptus Extract, Yukinoshita Extract, Yuzu Extract, Lily Extract, Yokuinin Extract, Mugwort Extract, Lavender Extract, Green Tea Extract, Eggshell Membrane Extract, Apple Extract, Rooibos Tea Extract, Ganoderma Extract, Lettuce Extract, Lemon Extract, Forsythia extract,
Preference is given to extracts such as astragalus extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, and bitumen extract.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like.
Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Astringents include citric acid, tartaric acid, lactic acid,
Examples thereof include aluminum sulfate / potassium sulfate and tannic acid. As enzymes,
Examples include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol,
Geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedryl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, Santa Roll, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute,
Jasmine lactone, cis-jasmon, citral, citronenol, citronellal,
Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylus resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nerol, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute, Vanillin, Basil oil, Patchouli oil, Hydroxycitronellal, α-pinene, Piperiton, Phenethyl alcohol, Phenylacetaldehyde, Petitgrain oil, Hexylcinna Mualdehyde, cis-3-hexenol, Peru balsam, vetiver oil, vetiverol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzy Benzoate, borneol, milresinoid, musk ketone, methylnonyl acetaldehyde, γ-methyl ionone, menthol, L-menthol, L-menton, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lyral, lyial, Synthetic fragrances such as lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils, natural fragrances, and various blended fragrances are preferred.

As pigments, colorants, dyes and pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 2
04, Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104- No. 1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 20
No. 2, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219,
Red 220, Red 221, Red 223, Red 225, Red 226, Red 227
No., Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red No. 405, Red No. 501, Red No. 502, Red 503, Red 504, Red 505, Red 506, Orange 201, Orange 20
No. 3, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 2
03, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 4
Legal pigments such as No. 03-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Yellow No. 5; Other acidic dyes such as Acid Red 14; Arianor Sienna Brown, Arianor Madder Re
Basic dyes such as d, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow
5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro
-Nitro dyes such as phenylenediamine, HC Blue 2, Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (Bengara) and iron titanate;
inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and loess; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; Inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, Pearl pigments such as bismuth oxychloride, fish scale foil; metal powder pigments such as aluminum powder, copper powder, gold; surface treatment inorganic and metal powder pigments; red 201, red 202, red 204, red 205, red 220 No., Red No. 226, Red No. 228, Red No. 405, Orange 20
No. 3, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red 10
No. 4, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1 Organic pigments such as zirconium, barium or aluminum lakes; surface treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, Natural pigments and dyes such as naphthoquinones such as shikonin, bixin, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-
Oxidative dye intermediates and couplers such as aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; auto-oxidizing dyes such as indoline; Dihydroxyacetone is preferred.

Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and
Handbook), ingredients listed in the Quasi-drug Raw Material Standards, Japanese Pharmacopoeia, Pharmaceutical Additive Standards, Food Additives Official Code, etc., and Japanese and foreign patents whose international patent classification IPC belongs to the classification of A61K7 Including known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., in known combinations, blending ratios, and blending quantities, such as ingredients described in publications and patent publications (including publications and republications) Is possible.

There are no particular restrictions on the type of cosmetic / skin external preparation of the present invention, except for hairdressing agents,
Preferable examples include skin external preparations such as hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and ointments. The cosmetic / skin external preparation of the present invention can be produced according to a usual method.

The types of cosmetics and skin external preparations of the present invention will be described in more detail. Basic cosmetics include soft lotions, astringent lotions, cleansing lotions, multi-layer lotions, etc .; emollient lotions, moisture Lotion, Milky Lotion, Nourishing Lotion, Nourishing Milk, Skin Moisture, Moisturizer Emulsion, Massage Lotion, Cleansing Lotion, Protect Emulsion, Sun Protect, Sun Protector,
Emulsions such as UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nourishing cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, Makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; Moisture gel, etc .; Moisturizing essence, whitening essence, UV protection essence, etc. Essence of liposomes; Liposome cosmetics such as liposomal serum and liposome lotion; peel-off pack, powder pack Packs and masks such as cleansing, washing packs, oil packs, cleansing masks; cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels, cleansing oils, cleansing masks, powders, facial cleansing powders, etc .; cosmetic soaps, Examples of preferable soaps include transparent soaps, medicated soaps, liquid soaps, shaving soaps, and synthetic cosmetic soaps.

As the makeup cosmetics, white powder, dusting powder, foundations, lipsticks, lip gloss, blushers, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment are preferable.

Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.

Body cosmetics such as body shampoos; deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics; A repeller is preferred.

Cosmetics for hair include oil shampoo, cream shampoo, conditioning shampoo, dandruff shampoo, hair color shampoo, shampoo with integrated rinse, shampoo for rinse, treatment, hair pack, color lotion, split coat, permanent wave Preference is given to agents, straight perm agents, oxidative hair dyes, hair bleaches, hair color pre-treatments, hair color after treatments, perm pre-treatments, perm after treatments, hair manicures, hair tonics and hair restorers.

As an external preparation for skin, it can be used as a dosage form such as an ointment, a patch, a lotion, a liniment, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

Examples of the dosage form of the cosmetic or external preparation for skin of the present invention include an oil-in-water (O / W) type and a water-in-oil (W / O).
) Type, W / O / W type, O / W / O type emulsified cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, kneaded cosmetics, stick cosmetics, volatile oil cosmetics Preferable dosage forms such as cosmetics, powdery cosmetics, jelly cosmetics, gel cosmetics, paste cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, spray cosmetics, etc. As mentioned.

EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example, this invention is not limited to these Examples. The weight average molecular weight described below is a value measured by a gel permeation chromatography (GPC) method using polystyrene having a known molecular weight as a standard.

Example 1
In a 1 L reactor equipped with a stirrer, a thermometer, and a gas introduction tube, 86.0 g (0.5 mol) of cyclohexanedicarboxylic acid (Eastman Chemical Co., Ltd., 1,4-CHDA) and polyethylene glycol (number average molecular weight) 300) 300 g (1.0 mol) is charged and 2 in a nitrogen stream
The mixture was heated to 10 to 220 ° C., and the esterification reaction was carried out for 24 hours while distilling off the generated water to obtain 362 g of Compound A. The weight average molecular weight of the obtained compound A was 1800.

Example 2
In a 1 L reactor equipped with a stirrer, a thermometer and a gas introduction tube, 51.6 g (0.3 mol) of cyclohexanedicarboxylic acid (Eastman Chemical Co., Ltd., 1,4-CHDA) and polyethylene glycol (number average molecular weight) 600) 360 g (0.6 mol) is charged, and in a nitrogen stream 2
The mixture was heated to 10 to 220 ° C., and the esterification reaction was carried out for 24 hours while distilling off the generated water to obtain 377 g of Compound B. The weight average molecular weight of the obtained compound B was 2200.

Example 3
In a 1 L reactor equipped with a stirrer, a thermometer, and a gas introduction tube, 17.2 g (0.1 mol) of cyclohexanedicarboxylic acid (Eastman Chemical Co., Ltd., 1,4-CHDA) and polyethylene glycol (number average molecular weight) 2000) 400 g (0.2 mol) was charged, heated to 210-220 ° C. in a nitrogen stream, and the esterification reaction was carried out for 36 hours while distilling off the generated water.
388 g of compound C was obtained. The obtained compound C had a weight average molecular weight of 8,100.

Example 4
In a 1 L reactor equipped with a stirrer, a thermometer, and a gas introduction tube, 17.2 g (0.1 mol) of cyclohexanedicarboxylic acid (Eastman Chemical Co., Ltd., 1,4-CHDA) and ethylene glycol / propylene glycol Polymer (manufactured by Sanyo Chemical Co., Ltd., New Pole PE-61,
Number average molecular weight 2000) 400 g (0.2 mol) is charged, and 210 to 220 ° C. in a nitrogen stream.
And the esterification reaction was carried out for 36 hours while distilling off the water formed,
g was obtained. The obtained compound D had a weight average molecular weight of 8,200.

Example 5
Dimer acid (manufactured by Unikema, PR
174 g (0.3 mol) of IPOL1025) and 240 g (0.6 mol) of polyethylene glycol (number average molecular weight 400) were charged, heated to 210-220 ° C. in a nitrogen stream, and esterified for 16 hours while distilling off the generated water. The reaction was carried out to obtain 376 g of Compound E. The weight average molecular weight of the obtained compound E was 5400.

Example 6
Dimer acid (manufactured by Unikema, PR
IPOL1025) 46.5 g (0.08 mol) and polyethylene glycol (number average molecular weight 2000) 320 g (0.16 mol) were charged, heated to 210-220 ° C. in a nitrogen stream, and distilled while distilling off the generated water. A time esterification reaction was performed to obtain 340 g of Compound F. The obtained compound F had a weight average molecular weight of 8,800.

Example 7
A 1 L reactor equipped with a stirrer, a thermometer, and a gas introduction tube was charged with 60.6 g (0.3 mol) of sebacic acid and 360 g (0.6 mol) of polyethylene glycol (number average molecular weight 600) in a nitrogen stream. The mixture was heated to 210 to 220 ° C., and the esterification reaction was carried out for 16 hours while distilling off the generated water, to obtain 397 g of Compound G. The weight average molecular weight of the obtained compound G is 2300.
Met.

Comparative Synthesis Example 1 (Synthesis of Comparative Example Compound H)
Dimer acid (manufactured by Unikema, PR
6.4 g (0.011 mol) of IPOL1025) and 440 g (0.022 mol) of polyethylene glycol (number average molecular weight 20000) were charged and heated to 210-220 ° C. in a nitrogen stream, while distilling off the generated water. Conduct time esterification reaction, 418 g of compound H
Obtained. The weight average molecular weight of the obtained compound H was 84000.

Evaluation Example 1 Moisturizing properties Compounds A to G obtained in Examples 1 to 7 and 1% aqueous solution of sodium hyaluronate and glycerin as comparative examples were prepared, respectively. Times 15
mg / cm 2 was applied continuously for 4 weeks. Then wash off the coated area with lukewarm water, 20 ° C
The skin was kept quiet for 30 minutes in an environment of 40% RH, and the keratin water content of the coated part was measured using Skicon-200 (manufactured by IBS). The measurement results are shown below. In addition, the value of a table | surface shows the average value of 10 panelists converted into 100 as the moisture content before continuous application | coating. From the following results, it can be seen that the product of the present invention has a better moisturizing function than sodium hyaluronate and glycerin that are widely used as moisturizing agents.

Compound name Relative value of keratin water content -------------------------------
Compound A 223
Compound B 240
Compound C 248
Compound D 186
Compound E 255
Compound F 232
Compound G 316
Sodium hyaluronate 157
Glycerin 133
-------------------------------

Evaluation Example 2 A 1% aqueous solution of each of Compounds A to G obtained in Sensory Evaluation Examples 1 to 7 and Compound H obtained in Comparative Synthesis Example 1 as a comparative example, sodium hyaluronate, and glycerin was prepared. It was applied to the inside of the forearm of 10 panelists, and the feeling of use at that time was evaluated. Evaluation is smooth,
We conducted three items: no stickiness and moist feeling. The results are shown below. In the table, ◎: 8 or more out of 10 responded good, ○: 6 or more out of 10 responded good, △: 4 or more out of 10 responded good, ×: 4 out of 10 Less than 1 person answered good. From the following results, it can be seen that the product of the present invention is less sticky and has a moist feeling than sodium hyaluronate and glycerin, which are widely used as humectants. It can also be seen that Compound E having a weight average molecular weight of 50,000 or more lacks smoothness and impairs the feeling of use.

Compound name Smoothness No stickiness Moist feeling -------------------------------
Compound A ◎ ◎ ◎
Compound B ◎ ◎ ◎
Compound C ◎ ◎ ◎
Compound D ◎ ◎ ◎
Compound E ◎ ◎ ◎
Compound F ○ ◎ ◎
Compound G ◎ ◎ ○
Compound H △ ◎ ○
Sodium hyaluronate ○ △ △
Glycerin ◎ △ ×
-------------------------------

Evaluation Example 13 Safety For the compounds A to G obtained in Examples 1 to 7, irritation was evaluated. As a method, a cytotoxicity test was performed using rabbit corneal cells (SIRC), and eye irritation was evaluated as follows. SIRC was inoculated in a 96-well plate in which each compound sample solution prepared in advance in a MEM medium containing 10% calf serum (FBS) was dispensed. After standing at room temperature for 20 minutes, CO for cells at 37 ° C
The culture was continued for 3 days in 2 incubators. Three days later, a neutral red assay was performed, and TC50 (50% cytotoxic concentration) was calculated. Based on the TC50 values obtained, the eye irritation was determined according to the criteria in accordance with the guidance guidelines “Guidelines for evaluating eye irritation of cosmetic ingredients using alternative methods” submitted by the Ministry of Health and Welfare in 1998. Sex determination was performed. The results are shown below. The following results show that the product of the present invention is excellent in safety.

Compound name Eye irritation -------------------------------
Compound A Unstimulated compound B Unstimulated compound C Unstimulated compound D Unstimulated compound E Unstimulated compound F Unstimulated compound G Unstimulated --------------------- -----------

Examples 8-14 Moisturizing lotion Using the compounds A to G obtained in Examples 1 to 7 and the compound H obtained in Comparative Synthesis Example 1, moisturizing lotions having the following formulation were prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compounds A to H 3.00
2 BG 1.00
3 Glycerin 2.00
4 Citric acid 0.01
5 Na citrate 0.10
6 Arginine 0.10
7 Glycyrrhizic acid 2K 0.05
8 Ethanol 7.00
9 Preservative appropriate amount
10 Fragrance
11 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1-6 are No. 11 and stirred and mixed uniformly (part A). Next, no. 9-10
No. No. 8 after dissolution in No. 8 7 was added and dispersed (part B). A part was added to part B with stirring to make it uniform.

The above moisturizing lotion containing the compounds A to G obtained in the present invention is excellent in feeling of use and moisturizing,
The skin was soft, fresh, smooth and moisturized, and these effects lasted for a long time. On the other hand, the above moisturizing lotion containing Comparative Example Compound H lacked the smoothness at the time of use and was inferior in the feeling of use.

Examples 15 to 21 A moisturizing lotion having the following formulation was prepared using the compounds A to G obtained in Examples 1 to 7 and the compound H obtained in Comparative Synthesis Example 1.

Component Blending amount (% by weight)
--------------------------------
1 Compounds A to H 1.00
2 BG 1.00
3 Diglycerin 2.00
4 Citric acid 0.01
5 Na citrate 0.05
6 Glycine 0.10
7 Glycyrrhizic acid 2K 0.05
8 Ethanol 3.00
9 Preservative appropriate amount
10 Fragrance
11 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1-6 are No. 11 and stirred and mixed uniformly (part A). Next, no. 9-10
No. No. 8 after dissolution in No. 8 7 was added and dispersed (part B). A part was added to part B with stirring to make it uniform.

The above moisturizing lotion containing the compounds A to G obtained in the present invention is excellent in feeling of use and moisturizing,
The skin was soft, fresh, smooth and moisturized, and these effects lasted for a long time. On the other hand, the above moisturizing lotion containing Comparative Example Compound H lacked the smoothness at the time of use and was inferior in the feeling of use.

Examples 22 to 28 Tightening lotion (astringent lotion)
Using the compounds A to G obtained in Examples 1 to 7 and the compound H obtained in Comparative Synthesis Example 1, a skin lotion having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compounds A to H 2.00
2 BG 2.00
3 Glycerin 0.04
4 Lactic acid 0.10
5 Lactic acid Na 0.05
6 Zinc phenol sulfonate 0.10
7 PEG-60 hydrogenated castor oil 0.50
8 Ethanol 15.00
9 Preservative appropriate amount
10 Fragrance
11 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1-7 are No. 11 and stirred and mixed uniformly (part A). Next, no. 9-10
No. 8 (part B). A part was added to part B with stirring to make it uniform.

The above-mentioned lotion lotion formulated with the compounds A to G obtained in the present invention is excellent in feeling of use and moisturizing, and gives a refreshing feel while keeping the skin soft and fresh, smooth and moisturized, These effects lasted for a long time. On the other hand, the above-mentioned lotion lotion containing Comparative Compound H lacked the smoothness at the time of use and was inferior in the feeling of use.

Examples 29 to 35 Cosmetic liquids Using the compounds A to G obtained in Examples 1 to 7 and the compound H obtained in Comparative Synthesis Example 1, a cosmetic liquid having the following prescription was prepared.

Component Blending amount (% by weight)
----------------------------------
Part A compounds A to H 15.00
Preservative appropriate amount PEG-40 hydrogenated castor oil 0.20
Purified water 5.00
Part B xanthan gum 0.40
Carbomer 0.10
BG 10.00
White jellyfish polysaccharide (Nippon Seika) 0.10
Purified water Amount to be 100 in total C part Hydroxide K (1% aqueous solution) 2.50
Purified water 10.00
Part D glycyrrhizic acid 2K 0.20
Purified water 5.00
----------------------------------

(Production method)
Part A was dissolved at room temperature. Part C was gradually added to B part while stirring to obtain a viscous liquid, and then part A and part D were added and stirred to make uniform.

The above-mentioned essence containing the compounds A to G obtained in the present invention has a high moisturizing effect and has a feeling of use such as a smooth feeling while keeping the skin soft, fresh and smooth with a moisturizing effect. Obtained, these effects lasted for a long time. On the other hand, the above-mentioned beauty essence which mix | blended the comparative example compound H lacked the smoothness at the time of use, and was inferior to a usability | use_condition.

Examples 36 to 42 Shampoos Using the compounds A to G obtained in Examples 1 to 7 and the compound H obtained in Comparative Synthesis Example 1, shampoos having the following formulations were prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compounds A to H 3.00
2 Naureth sulfate Na (27%) 30.00
3 Lauroamphoacetate Na (25%) 10.00
4 PPG-2 Cocamide 1.50
5 Lauramide MPA 1.00
6 Polyquaternium-10 0.20
7 Methylisothiazolinone 0.10
8 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1 to 5 were heated to about 80 ° C. and dissolved uniformly (part A). Next, no. 6-8 about 8
Heated to 0 ° C. and dissolved uniformly (Part B). Part B was added to part A and mixed with stirring at about 80 ° C. until uniform, and then cooled. No. The prescription except 1 was used as a blank.

Ten panelists evaluated the hair feel after using the shampoo. The evaluation was performed for two items, a slippery feeling and a moist feeling. The results are shown below. In the table, ◎: 8 or more out of 10 responded that better than blank, ○: 6 or more out of 10 responded that better than blank, △: 1
4 or more out of 0 responded that it was better than blank, and x: less than 4 out of 10 answered that it was better than blank. As shown below, it can be seen that the shampoo containing the product of the present invention can impart a moist feeling and smooth fingering to the hair as compared with the non-compounded product, and is also excellent as a fat additive. On the other hand, the shampoo containing the comparative compound H was inferior to the slip feeling.

Compound name Smooth feeling Moist feeling -------------------------------
Compound A ◎ ◎
Compound B ◎ ◎
Compound C ◎ ◎
Compound D ○ ○
Compound E ○ ◎
Compound F ○ ○ ○
Compound G ○ ◎
Compound H × ○
-------------------------------

Examples 43 to 49 Shampoos Using the compounds A to G obtained in Examples 1 to 7 and the compound H obtained in Comparative Synthesis Example 1, shampoos having the following formulations were prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compounds A to H 3.00
2 Cocamidopropyl betaine (40%) 40.00
3 Cocoa glutamate TEA (27%) 10.00
4 Tetradecenesulfonic acid Na (36%) 2.00
5 PEG120-Methylglucose dioleate 3.00
6 Triethanolamine 0.20
7 Methylisothiazolinone 0.10
8 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1 to 5 were heated to about 80 ° C. and dissolved uniformly (part A). Next, no. 6-8 about 8
Heated to 0 ° C. and dissolved uniformly (Part B). Part B was added to part A and mixed with stirring at about 80 ° C. until uniform, and then cooled. No. The prescription except 1 was used as a blank.

Ten panelists evaluated the hair feel after using the shampoo. The evaluation was performed for two items, a slippery feeling and a moist feeling. The results are shown below. In the table, ◎: 8 or more out of 10 responded that better than blank, ○: 6 or more out of 10 responded that better than blank, △: 1
4 or more out of 0 responded that it was better than blank, and x: less than 4 out of 10 answered that it was better than blank. As shown below, it can be seen that the shampoo containing the product of the present invention can impart a moist feeling and smooth fingering to the hair as compared with the non-compounded product, and is also excellent as a fat additive. On the other hand, the shampoo containing the comparative compound H was inferior to the slip feeling.

Compound name Smooth feeling Moist feeling -------------------------------
Compound A ◎ ○
Compound B ◎ ◎
Compound C ◎ ○
Compound D ○ ○
Compound E ○ ◎
Compound F ◎ ○
Compound G △ ○
Compound H × ○
-------------------------------

Examples 50 to 56 Shampoos Using the compounds A to G obtained in Examples 1 to 7 and the compound H obtained in Comparative Synthesis Example 1, shampoos having the following formulations were prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compounds A to H 1.00
2 Naureus sulfate (27%) 50.00
3 Cocamidopropyl betaine (30%) 10.00
4 Cocamide DEA 2.00
5 SUCRAPH AG-8 (Nippon Seika) 2.00
6 quaternium-33 0.40
7 Polyquaternium-10 0.40
8 Phenoxyethanol 0.20
9 Methylparaben 0.20
10 Sodium benzoate 0.40
11 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1 to 5 were heated to about 80 ° C. and dissolved uniformly (part A). Next, no. 6 to 11 were heated to about 80 ° C. and dissolved uniformly (part B). Add part B to part A and keep it at 80 ° C until uniform
The mixture was stirred and then cooled. No. The prescription except 1 was used as a blank.

Ten panelists evaluated the hair feel after using the shampoo. The evaluation was performed for two items, a slippery feeling and a moist feeling. The results are shown below. In the table, ◎: 8 or more out of 10 responded that better than blank, ○: 6 or more out of 10 responded that better than blank, △: 1
4 or more out of 0 responded that it was better than blank, and x: less than 4 out of 10 answered that it was better than blank. As shown below, it can be seen that the shampoo containing the product of the present invention can impart a moist feeling and smooth fingering to the hair as compared with the non-compounded product, and is also excellent as a fat additive. On the other hand, the shampoo containing the comparative compound H was inferior to the slip feeling.

Compound name Smooth feeling Moist feeling -------------------------------
Compound A ◎ ◎
Compound B ◎ ◎
Compound C ◎ ◎
Compound D ○ ◎
Compound E ○ ◎
Compound F ○ ◎
Compound G ◎ ◎
Compound H × ○
-------------------------------

Example 57 Shampoo Using the compound F obtained in Example 6, a shampoo having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound F 3.00 obtained in Example 6
2 Cocoa glutamate TEA (27%) 20.00
3 Tetradecenesulfonic acid Na (36%) 1.50
4 PEG120-methyl glucose dioleate 1.50
5 Polyquaternium-10 0.20
6 Methylisothiazolinone 0.10
7 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1-4 were heated to about 80 ° C. and dissolved uniformly (part A). Next, no. 5-7 about 8
Heated to 0 ° C. and dissolved uniformly (Part B). Part B was added to part A and mixed with stirring at about 80 ° C. until uniform, and then cooled.

This shampoo was able to give moist and smooth fingering to the hair.

Example 58 Treatment Using the compound B obtained in Example 2, a treatment having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Cetanol 6.00
2 Oleyl alcohol 1.00
3 NS-IPP (Nippon Seika) 1.00
4 Nacococoafoacetate (30%) 1.60
5 Stearamidopropyldimethylamine 2.00
6 Glyceryl stearate 0.80
7 Compound B obtained in Example 2 1.00
8 Lactic acid 0.70
9 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1 to 6 were heated to about 80 ° C. and dissolved uniformly (part A). Next, no. 7-9 about 8
Heated to 0 ° C. and dissolved uniformly (Part B). Part B was added to part A and stirred and mixed uniformly, and then cooled to room temperature.

This treatment was able to give the hair a moist feeling and smooth fingering.

Example 59 Treatment Using the compound F obtained in Example 6, a treatment having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Cetanol 4.50
2 Oleyl alcohol 0.50
3 Olive oil 0.50
4 BY11-007 (Toray Dow Corning) 2.00
5 Steartrimonium chloride (70%) 1.00
6 Behentrimonium chloride (80%) 2.00
7 Compound F 3.00 obtained in Example 6
8 Methylparaben 0.10
9 Propylparaben 0.10
10 Lactic acid Na (50%) 0.20
11 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1 to 6 were heated to about 80 ° C. and dissolved uniformly (part A). Next, no. 7 to 11 were heated to about 80 ° C. and dissolved uniformly (part B). Part B was added to part A and stirred and mixed uniformly, and then cooled to room temperature.

This treatment can impart a moist and soft feeling to the hair.

Example 60 Emollient cream Using compound B obtained in Example 2, an emollient cream having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound B 6.00 obtained in Example 2
2 Hydrogenated palm oil 2.50
3 Behenyl alcohol 2.00
4 Dimethicone (10cs) 1.50
5 Glyceryl stearate 1.50
6 Stearyl alcohol 1.20
7 Stearic acid PG (SE) 1.00
8 PEG-60 glyceryl isostearate 1.00
9 Octyl methoxycinnamate 0.20
10 Ethylparaben 0.10
11 1,3-butylene glycol 6.00
12 Glycerin 1.00
13 Phenoxyethanol 0.20
14 Methylparaben 0.15
15 Purified water 75.65
--------------------------------

(Preparation method)
No. 1-10 were added, and it heated and melt | dissolved at about 80 degreeC (A part). No. in a separate container. 11-
15 was heated to about 80 ° C. and dissolved uniformly (Part B). Part B was added to part A, emulsified with a homomixer, and then cooled to 40 ° C.

This emollient cream was a cream excellent in the effect of imparting a moist feeling.

Example 61 Sunscreen Agent Using compound E obtained in Example 5, a sunscreen agent having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound E 11.70 obtained in Example 5
2 Squalane 22.50
3 LUSPLAN PI-DA (Nippon Seika) 2.70
4 Microcrystalline wax 2.70
5 Distearate Al 1.60
6 Mg stearate 1.60
7 1,3-butylene glycol 5.00
8 Behenyl alcohol 4.80
9 Composite-PC (Nippon Seika) 1.00
10 Cholesterol 0.80
11 Propylparaben 0.20
12 Methylparaben 0.20
13 Titanium oxide 9.00
14 Mg sulfate 0.50
15 Purified water 35.70
--------------------------------

(Preparation method)
No. No. 13 Nos. 1 and 2 3 was added and kneaded with a mill (part A). N in a separate container
o. No. 2 4-6 were added and it heated and dissolved at about 150 degreeC (part B). No. in a separate container. No. 1 No. 7-12 were added, and it heated and dissolved at about 80 degreeC (part C). No. in a separate container. 14, 15 was added, and the mixture was heated to about 80 ° C. and dissolved (part D). Add part C to part B,
After mixing, it was added to part A and mixed uniformly. Subsequently, D part was added, it stirred, and it cooled to 40 degreeC after emulsification.

This sunscreen agent was a cream that suppressed breakage due to sweat and had a moist feeling.

Example 62 Base Cream Using the compound F obtained in Example 6, a base cream having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound F 5.00 obtained in Example 6
2 Cyclomethicone 15.00
3 Trimethylsiloxysilicate 3.00
4 Glyceryl stearate (SE) 2.00
5 PG stearate (SE) 2.00
6 Macadamia nut fatty acid phytosteryl 2.00
7 Stearic acid 0.50
8 Palmitic acid 0.50
9 Octyl methoxycinnamate 0.50
10 Tocopherol 0.20
11 1,3-butylene glycol 10.00
12 Mica 8.00
13 Talc 7.00
14 Phenoxyethanol 0.80
15 Titanate (Li / Cobalt) 0.20
16 Xanthan gum (10%) 2.00
17 Cellulose gum (10%) 2.00
18 Purified water 39.30
--------------------------------

(Preparation method)
No. 16 and 17 are No. It was dissolved in 18 to give a viscous liquid (2%) (part A). No. in a separate container. 1-10 was added, and it heated and dissolved at about 80 degreeC (B part). No. in a separate container. 11
-15, No. The remainder of 18 was added and heated to about 80 ° C. and dissolved (part C). After adding part C to part B and emulsifying, part A was added and mixed uniformly. It cooled to 40 degreeC after stirring.

This base cream was a base cream that had good elongation, had a foundation, had a good feel, and was able to impart a light touch.

Example 63 Foundation Using the compound G obtained in Example 7, a foundation having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound G 6.00 obtained in Example 7
2 Cyclomethicone 3.50
3 Dimethicone (5cs) 2.00
4 Trimethylsiloxysilicic acid 1.50
5 Octyl methoxycinnamate 1.00
6 Phenoxyethanol 0.40
7 Tocopherol 0.10
8 Mica 39.60
9 Talc 24.00
10 Titanium oxide 20.00
11 Iron oxide 1.90
--------------------------------

(Preparation method)
Each component was stirred at high speed and mixed uniformly.

This foundation had excellent color development and a moist feel.

Example 64 Lipstick Using the compound C obtained in Example 3, a lipstick having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound C 1.00 obtained in Example 3
2 Cetyl octoate 22.50
3 Trioctanoin 28.50
4 Cyclomethicone 16.00
5 Ceresin 9.00
6 Candelilla wax 5.00
7 LUSPLAN PI-DA (Nippon Seika) 5.00
8 Sorbitan sesquiisostearate 4.00
9 Macadamia nut oil 1.00
10 Tocopherol 0.50
11 Iron oxide 2.25
12 Titanium oxide 2.25
13 Mica 1.50
14 Red 202 1.50
--------------------------------

(Preparation method)
No. Nos. 11-14 are No. 1 and 2 were kneaded (part A). No. in a separate container. Add 3-10,
The mixture was heated to about 80 ° C. and dissolved (Part B). At about 80 ° C., part A was added to part B, dissolved, and then rapidly cooled.

This lipstick was fresh and highly adhesive.

Example 65 Lip gloss A lip gloss having the following formulation was prepared using the compound A obtained in Example 1.

Component Blending amount (% by weight)
--------------------------------
1 Compound A 2.00 obtained in Example 1
2 Dextrin palmitate 10.00
3 Macadamia nut oil fatty acid phytosteryl 43.00
4 Methylphenylpolysiloxane 30.00
5 Trioctanoin 10.00
6 Liquid paraffin 5.00
--------------------------------

(Preparation method)
No. 1 and 2 were heated to 100 to 110 ° C. and dissolved uniformly. Next, no. 3-6 were added and it was made to melt | dissolve uniformly at about 80 degreeC.

This lip gloss was fresh and had high adhesion.

Example 66 Cleansing oil Using the compound D obtained in Example 4, cleansing oil having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound D 1.00 obtained in Example 4
2 Laureth-4 7.00
3 Tocopherol appropriate amount
4 Propylparaben appropriate amount
5 Cetyl octoate Total amount of 100
6 Mineral oil 10.00
--------------------------------

(Preparation method)
All ingredients were heated and dissolved and mixed.

This cleansing oil is transparent, viscous and has the property of not dripping when in use,
It feels refreshing and is familiar with foundations, makeup, etc., and can be quickly removed.

Example 67 Mascara Using the compound C obtained in Example 3, a mascara having the following formulation was produced.

Component Blending amount (% by weight)
---------------------------------
1 Iron oxide (black) 10.00
2 Light isoparaffin 30.00
3 Polyacrylate emulsion 30.00
4 Solid paraffin 8.00
5 Compound C 1.20 obtained in Example 3
6 Sorbitan sesquioleate 4.00
7 Preservative appropriate amount
8 Perfume appropriate amount
9 Purified water Total amount of 100 ---------------------------------

(Preparation method)
No. No. 9 no. No. 1 was added and dispersed with a homomixer. Add 3 and heat to 70
Maintained at ° C (aqueous phase). The other ingredients were mixed and heated to 70 ° C. (oil phase). The aqueous phase was added to the oil phase, and the mixture was uniformly emulsified and dispersed with a homomixer to obtain the desired mascara.

This mascara had good adhesion, good usability, and good stability.

Example 68 Eyeshadow An eye shadow having the following formulation was produced using Compound E obtained in Example 5.

Component Blending amount (% by weight)
---------------------------------
1 Talc 10.00
2 Kaolin 2.00
3 facial 5.00
4 Compound E 3.00 obtained in Example 5
5 Stearic acid 3.00
6 Isopropyl myristate 5.00
7 Liquid paraffin 5.00
8 Propylene glycol monolaurate 3.00
9 Antioxidant appropriate amount
10 Incense amount
11 1,3-butylene glycol 5.00
12 Glycerin 1.00
13 Preservative appropriate amount
14 Triethanolamine 1.20
15 Suitable amount of sequestering agent
16 Purified water Total amount of 100 ---------------------------------

(Preparation method)
No. 1-3 were mixed with a blender and then processed with a pulverizer (powder part). No. 11-16
Was dissolved by heating at 70 to 75 ° C. (aqueous phase part). No. 4 to 10 were dissolved by heating at 70 to 80 ° C. (oil phase part). The powder part was added to the aqueous phase part and mixed with stirring. The oil phase was added to this while stirring, dispersed with a homomixer, and stirred and cooled to room temperature to obtain the desired eye shadow.

This emulsified eye shadow had good adhesion, good usability, and good emulsification stability.

Example 69 Mild Shampoo Using the compound F obtained in Example 6, a mild shampoo having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound F 0.50 obtained in Example 6
2 Cocoyl methyl methyl taurine Na (30%) 30.00
3 Cocamidopropyl betaine (30%) 20.00
4 Laureth-12 Na acetate (30%) 5.00
5 1,3-Butylene glycol 1.00
6 Cocamide MEA 2.00
7 Glycol distearate 1.50
8 Polyquaternium-10 0.50
9 Polyquaternium-7 0.30
10 Cationic NH (Nippon Seika) 0.50
11 Sodium benzoate 0.40
12 Phenoxyethanol 0.20
13 Methylparaben 0.20
14 Purified water 37.90
--------------------------------

(Preparation method)
No. 1 to 7 were heated to about 80 ° C. and dissolved (part A). No. in a separate container. 8-14 about 8
Heated to 0 ° C. to dissolve (Part B). While stirring Part B into Part A, they were gradually added and mixed uniformly, and then rapidly cooled.

This mild shampoo was a shampoo capable of imparting a moist feeling to the hair and providing smooth fingering.

Example 70 Moistrin The compound G obtained in Example 7 was used to prepare a moistrin having the following formulation.

Component Blending amount (% by weight)
--------------------------------
1 Compound G 0.10 obtained in Example 7
2 Plandool-H (Nippon Seika) 0.50
3 Cetrimonium chloride (30%) 5.20
4 Octild decanol 4.70
5 Cetanol 2.80
6 Steartrimonium chloride (63%) 0.60
7 Cetyl octanoate 0.30
8 Squalane 0.30
9 Myristyl sulfate Na 0.20
10 Seths-40 0.10
11 Ores-5 0.10
12 Cetyl sulfate Na 0.10
13 Citric acid 0.10
14 Methylparaben 0.10
15 Purified water 84.80
--------------------------------

(Preparation method)
No. 1 to 12 were heated to about 80 ° C. and dissolved (part A). No. in a separate container. 14 to 15 were heated to about 80 ° C. and dissolved (Part B). While stirring Part B into Part A, gradually add and mix uniformly. After 13 was added and stirred, it was quenched.

This moisturizing was a non-sticky rinse that gave the hair a moist feeling and a smooth fingering.

Example 71 Treatment Using the compound B obtained in Example 2, a treatment having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound B 2.00 obtained in Example 2
2 Glyceryl stearate (SE) 4.50
3 Steerless-10 4.00
4 Cetanol 4.00
5 Steartrimonium chloride (63%) 1.80
6 LUSPLAN DD-IS (Nippon Seika) 1.50
7 Behentrimonium chloride (80%) 1.00
8 Methylparaben 0.20
9 Purified water 81.00
--------------------------------

(Preparation method)
No. No. 9 was heated to about 80 ° C. 8 was added and dissolved (part A). No. in a separate container. 1 to
7 was added, heated and dissolved (part B). Part A was gradually added to part B and mixed uniformly.

This treatment was a treatment that kept the moisture of the hair and was able to give a supple, moist and smooth feel.

Example 72 Straight Perm Agent (Cation Type)
Using Compound A obtained in Example 1, 1 part and 2 parts of a straight perm agent (cation type) having the following formulation were prepared.

(1 liquid)
Component Blending amount (% by weight)
--------------------------------
1 Compound A 0.50 obtained in Example 1
2 Cetanol 5.00
3 Steartrimonium chloride (63%) 2.40
4 Seths-20 2.40
5 TRIBEHENIN PEG-20 ESTERS 2.00
6 Seths-6 0.80
7 Lauramide MIPA 0.80
8 PEG-60 hydrogenated castor oil 0.40
9 Ammonium thioglycolate solution (50%) 13.50
10 Monoethanolamine 1.70
11 Polyquaternium-6 1.30
12 Hydrolyzed soy protein 1.00
13 EDTA-4Na 0.10
14 Ammonia water (28%) 1.10
15 Purified water 67.00
--------------------------------

(Preparation method)
No. Most of 15 were heated to about 80 ° C. (Part A). No. in a separate container. 1-8 were added and it heated and dissolved (part B). No. in a separate container. No.15, no. 9 to 13 were added and dissolved uniformly (part C). Part B was added to part A, mixed and stirred, and part C was added at about 45 ° C. and mixed uniformly. After cooling to room temperature, no. 14 was added.

(2 liquids)
Component Blending amount (% by weight)
--------------------------------
1 Compound A 2.00 obtained in Example 1
2 Cetanol 5.00
3 Emmacol VT-20 (Sanei Chemical) 5.00
4 Dimethicone (200cs) 2.00
5 Trioctanoin 2.00
6 Octyldodecanol 0.60
7 Seths-20 0.50
8 Diammonium phosphate 0.20
9 Sodium benzoate 0.15
10 Na bromate 8.00
11 Purified water 74.55
--------------------------------

(Preparation method)
No. 1-7 were added, it heated at about 70 degreeC, and it was made to melt | dissolve (A part). No. in a separate container. No. 11 was taken and heated to about 70 ° C. 8 and 9 were added and dissolved (part B). No in a separate container
. No. 11 was taken and heated to about 60 ° C. 10 was added and dissolved (part C). About 70
B part was added to A part at 0 degreeC, and it stirred until the viscosity became high. The mixture was cooled to 60 ° C., and part C was added with stirring and mixed uniformly. After the temperature dropped to about 50 ° C., it was rapidly cooled.

This straight perm solution is a straight perm solution that can be applied to the straight perm firmly because it has high adhesion to hair and has a setting power.

Example 73 Hair bleaching agent (2 agent type)
Using the compound G obtained in Example 7, a hair bleaching agent (two-agent formula) having the following formulation was prepared.

(1 agent)
Component Blending amount (% by weight)
--------------------------------
1 Compound G 0.50 obtained in Example 7
2 Polyoxyethylene oleyl ether 52.00
3 Ammonia water (25%) 25.50
4 Cetrimonium chloride (30%) 10.00
5 Ethanol 10.00
6 Purified water 4.50
--------------------------------

(Preparation method)
Each component was stirred and mixed uniformly.

(2 agents)
Component Blending amount (% by weight)
--------------------------------
1 Hydrogen peroxide solution 17.00
2 Cetrimonium chloride (30%) 10.00
3 Cetanol 3.00
4 Seths-2 1.00
5 Seths-20 1.00
6 Na pyrophosphate 0.10
7 Diethylenetriaminepentaacetic acid 0.10
8 Citric acid (50%) appropriate amount
9 Purified water Total amount of 100 --------------------------------

(Preparation method)
Each component was mixed uniformly, and the pH was adjusted to 3.5 to 4.0 with citric acid.

(Mixing ratio)
1 agent: 2 agents = 1: 7

This depigmenting agent (two-component type) is a depigmenting agent that reduces the sense of hair damage after depigmentation and gives the hair a good feel such as flexibility, moistness, and slipping. there were.

Example 74 Oxidative hair dye Using the compound B obtained in Example 2, an oxidative hair dye having the following formulation was prepared.

(1 agent)
Component Blending amount (% by weight)
--------------------------------
1 Compound B 0.50 obtained in Example 2
2 Cetrinium chloride (25%) 24.00
3 Cetanol 9.00
4 Octild decanol 9.00
5 Monoethanolamine 3.80
6 Ammonia water 2.00
7 Myristyl sulfate Na 1.50
8 Ores-20 1.40
9 Toluene-2,5-diamine hydrochloride 1.00
10 Resorcin 1.00
11 Metaaminophenol 0.50
12 Paraaminophenol 0.20
13 Orthoaminophenol 0.10
14 Ascorbic acid 0.20
15 Fragrance 0.10
16 Purified water 45.70
--------------------------------

(Preparation method)
Each component was mixed uniformly.

(2 agents)
Component Blending amount (% by weight)
--------------------------------
1 Hydrogen peroxide solution 17.00
2 Cetrinium chloride (30%) 10.00
3 Cetanol 3.00
4 Seths-2 1.00
5 Seths-20 1.00
6 Na pyrophosphate 0.10
7 Diethylenetriaminepentaacetic acid 0.10
8 Citric acid (50%) appropriate amount
9 Purified water Total amount of 100 --------------------------------

(Preparation method)
Each component was mixed uniformly, and the pH was adjusted to 3.5 to 4.0 with citric acid.

(Mixing ratio)
1 agent: 2 agents = 1: 1

This oxidative hair dye is an oxidative hair dye that reduces the feeling of hair damage after hair dyeing and gives the hair a good feel such as flexibility, moist feeling, and slipperiness. It was.

Example 75 Curling Agent A curling agent having the following formulation was produced using Compound F obtained in Example 6.

(1 liquid)
Component Blending amount (% by weight)
---------------------------------
1 Cysteamine hydrochloride 2.00
2 DL cysteine 0.40
3 Monoethanolamine 0.90
4 Ammonia water (28%) 0.50
5 POE20 palm oil fatty acid sorbitan 0.50
6 Fragrance 0.10
7 Diallylammonium chloride / acrylic acid copolymer 1.00
8 Emmacol VT-20 (Sanei Chemical) 3.00
9 Ores-20 0.50
10 Ores-50 0.20
11 Compound F 0.50 obtained in Example 6
12 Lanolin fatty acid octyldodecyl 0.30
13 Sorbitan monostearate 0.20
14 tetrasodium edetate tetrahydrate 0.10
15 Ammonium phosphate 0.50
16 Purified water Total amount of 100 ---------------------------------

(Preparation method)
No. No. 16 in part (20%) 1 to 3 was added and dissolved, and No. 1 was previously stored in a separate container.
No. 16 in part (10%) What was melt | dissolved by adding 14 and 15 was added at about 40 degreeC, and it was made to melt | dissolve uniformly (part A). In another container, no. The remainder of 16 was heated to about 75 ° C. (Part B)
. In another container 8-13 were taken and heated to about 75 ° C. to dissolve (Part C). B in part C
After adding part and emulsifying and stirring and mixing well, it was cooled to 40 ° C. and part A was added and stirred uniformly. Next, no. No. 7 was added and stirred. Nos. 5 and 6 were added. 4 was added, and the mixture was stirred and mixed uniformly to adjust the pH to 9.0 to 9.5, thereby obtaining the target curling agent 1 solution.

(2 liquids)
Component Blending amount (% by weight)
----------------------------------
1 EDTA-2Na 0.10
2 Na bromate 4.00
3 Ammonium phosphate 0.50
4 Cationic NH (Nippon Seika) 2.00
5 Cetrinium chloride (30%) 1.00
6 Ores-50 0.20
7 Dimethicone copolyol 0.50
8 Sodium benzoate 0.15
9 Purified water Total amount of 100 -----------------------------------

(Preparation method)
No. 4-7 were heated to about 80 ° C. and dissolved (part A). In another container Part of 9 (7
0%) and no. 1 and 8 were added and heated to about 80 ° C. to dissolve (Part B). In another container, no. No. 9 and No. 9 A few were added and heated to about 50 ° C. to dissolve (Part C). B in part A
Part is added, mixed and stirred uniformly to emulsify, and when it reaches 40 ° C., part C is added and mixed well.
The target curling agent 2 liquid was obtained by adjusting the pH to 6.5 to 6.8 at room temperature.

By using the curl agent 1 and 2 produced in this way for the hair, it was possible to curl with good flexibility, slipperiness, moist texture, and good finish.

Example 76 Pasty lipstick Using compound F obtained in Example 6, a pasty lipstick having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound F 2.00 obtained in Example 6
2 12-Hydroxystearic acid 8.00
3 Liquid paraffin Amount that totals 100
4 Trioctanoin 30.00
5 Silicic anhydride 0.30
(Aerosil R974 manufactured by Nippon Aerosil Co., Ltd.)
6 Red 202 No.
7 Yellow No. 4 Appropriate amount --------------------------------

(Preparation method)
No. 1-7 are heated and mixed uniformly.

This lipstick was excellent in terms of gloss and odor, and had a smooth and sticky feeling when applied.

Example 77 Solid powdery foundation Using the compound G obtained in Example 7, a solid powdery foundation having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound G 10.00 obtained in Example 7
2 Perfluoropolyether 5.00
3 Silicone-treated sericite 60.00
4 Titanium oxide 10.00
5 Powdered synthetic hydrocarbon wax 1.00
6 Yellow iron oxide 1.00
7 Bengala 0.50
8 Methylparaben 0.50
9 Black iron oxide 0.05
10 Talc Total amount of 100 --------------------------------

(Preparation method)
No. Add 1-2, warm to about 70 ° C. and mix (Part A). No. in a separate container. Take 3 to 10 and mix and disperse (Part B). Add part A to part B and mix evenly.

This solid powdery foundation was excellent in feeling of use, adhesion to the skin, persistence of makeup, smell and the like.

Example 78 Hair Cream A hair cream having the following formulation was prepared using Compound A obtained in Example 1.

Component Blending amount (% by weight)
--------------------------------
1 Compound A 2.00 obtained in Example 1
2 Cetanol 4.00
3 Dimethicone (500cs) 13.00
4 Glyceryl stearate 2.80
5 Ores-10 phosphate 0.80
6 Glyceryl stearate (SE) 1.60
7 Phenoxyethanol 0.40
8 Methylparaben 0.20
9 10% NaOH 0.60
10 Purified water 74.60
--------------------------------

(Preparation method)
No. 1 to 6 were heated to about 80 ° C. and dissolved (part A). No. in a separate container. 7-10 were added, and it heated and melt | dissolved at about 80 degreeC (B part). Part B was added to part A and mixed with stirring.

This hair cream was glossy, non-sticky, kept the moisture of the hair, and could give a smooth feel.

Example 79 Hair Cream A hair cream having the following formulation was prepared using Compound E obtained in Example 5.

Component Blending amount (% by weight)
--------------------------------
1 Compound E 1.00 obtained in Example 5
2 Cetanol 4.00
3 Isodecyl neopentanoate 15.00
4 Stearic acid PG (SE) 1.70
5 Glyceryl stearate 2.70
6 Ores-8 phosphate 0.70
7 Phenoxyethanol 0.40
8 Methylparaben 0.20
9 Purified water 74.30
--------------------------------

(Preparation method)
No. 1 to 6 were heated to about 80 ° C. and dissolved (part A). No. in a separate container. Add 7-9,
The mixture was heated to about 80 ° C. and dissolved (Part B). Part B was added to part A and mixed with stirring.

This hair cream was glossy, non-sticky, kept the moisture of the hair, and could give a smooth feel.

Example 80 Rinse-in shampoo Using the compound B obtained in Example 2, a rinse-in shampoo having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound B obtained in Example 2 1.00
2 Cocamidopropyl betaine (30%) 20.00
3 Lauryl sulfate TEA (40%) 15.00
4 Cocamide DEA 2.00
5 Cocoa glutamate TEA (30%) 30.00
6 Ethylene glycol distearate 1.20
7 Polyquaternium-10 1.60
8 Stearyl trimonium bromide (70%) 0.60
9 Phenoxyethanol 0.20
10 Methylparaben 0.20
11 Sodium benzoate 0.40
12 Purified water 27.80
--------------------------------

(Preparation method)
No. 7, 8 and 12 were heated to about 80 ° C. and mixed with stirring. Next, no. 3 and add
Furthermore, no. Add 1, 2, 4 to 6 and stir until uniform. 9-11 were added and dissolved.

This rinse-in shampoo imparts a moist feeling to the hair and can provide smooth fingering.

Example 81 Shampoo Using the compound G obtained in Example 7, a shampoo having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound G 0.80 obtained in Example 7
2 Sodium lauryl sulfate (25%) 45.00
3 Olefin (C14-16) sulfonic acid Na (37%) 4.00
4 Cocamidopropyl betaine (30%) 6.00
5 Cocamide DEA 3.40
6 Ethylene glycol distearate 1.80
7 Phenoxyethanol 0.20
8 Methylparaben 0.20
9 Sodium benzoate 0.40
10 Concentrated glycerin 2.40
11 10% citric acid appropriate amount
12 Polyquaternium-10 0.80
13 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 12-13 were heated to about 80 ° C. and dissolved uniformly. Next, no. Add 2-6 and stir and mix at about 80 ° C. until uniform, then No. 2 1 was added and dissolved uniformly. No further
. 7-10 are added and dissolved. 11 to pH 6-7.

This shampoo was able to give a moist feeling to the hair and give smooth fingering.

Example 82 Treatment Using the compound A obtained in Example 1, a treatment having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound A 0.80 obtained in Example 1
2 Cetanol 6.00
3 Trioctanoin 1.60
4 Cetyl octanoate 1.60
5 Stearyl trimonium bromide (70%) 0.60
6 Dimethylaminopropylamide stearate 1.00
7 10% citric acid 2.00
8 Purified water 86.40
--------------------------------

(Preparation method)
No. 1 to 6 were heated to about 80 ° C. and dissolved uniformly. Next, No. 2 was heated to about 80 ° C. 8
Is added, and mixed uniformly. 7 was dissolved.

This treatment was a treatment capable of keeping the moisture of the hair and imparting a moist and smooth feel to the hair.

Example 83 Treatment Using the compound E obtained in Example 5, a treatment having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound E 1.00 obtained in Example 5
2 Cetanol 6.00
3 Squalane 2.00
4 Trioctanoin 2.00
5 Dimethylaminopropylamide stearate 2.00
6 Cocoamphoacetate Na (30%) 1.60
7 Phenoxyethanol 0.40
8 Lactic acid 0.80
9 Purified water 84.20
--------------------------------

(Preparation method)
No. 1 to 6 were heated to about 80 ° C. and dissolved uniformly (part A). Next, no. 7-9 were added and it was made to melt | dissolve uniformly (B part). Part B was added to part A and dissolved uniformly.

This treatment was a treatment capable of keeping the moisture of the hair and imparting a moist and smooth feel to the hair.

Example 84 Emollient Cream Using compound C obtained in Example 3, an emollient cream having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound C 1.20 obtained in Example 3
2 Cetyl octanoate 6.60
3 Hydrogenated palm oil 4.20
4 Glyceryl stearate (SE) 2.20
5 PEG-60 glyceryl isostearate 1.90
6 Stearic acid PG (SE) 0.60
7 Stearyl alcohol 0.60
8 Dimethicone (10cs) 1.80
9 Ethylparaben 0.10
10 1,3-butylene glycol 3.00
11 Glycerin 1.00
12 Phenoxyethanol 0.20
13 Methylparaben 0.15
14 Purified water 76.45
--------------------------------

(Preparation method)
No. 1 to 9 were heated to about 70 ° C. and dissolved uniformly (part A). Next, no. 10-14 were heated to about 70 ° C. and dissolved uniformly (part B). To Part A, Part B was added with stirring and emulsified, and then cooled.

This emollient cream was a cream excellent in the effect of imparting a moist feeling.

Example 85 Emollient Cream Using compound E obtained in Example 5, an emollient cream having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound E 3.00 obtained in Example 5
2 Cetyl octanoate 5.00
3 PEG-60 glyceryl isostearate 1.50
4 Hydrogenated palm oil 14.00
5 Ethylparaben 0.20
6 Stearyl alcohol 3.50
7 Glyceryl stearate (SE) 1.00
8 Steerless-6 1.50
9 PEG-8 distearate 1.00
10 Cetanol 3.00
11 Cetyl palmitate 2.00
12 Isocetyl myristate 5.00
13 Cetyl dimethicone copolyol 0.50
14 Tocopherol 0.20
15 Dimethicone (10cs) 1.00
16 Glycerin 4.00
17 Methylparaben 0.20
18 1,3-butylene glycol 6.00
19 Purified water 47.40
--------------------------------

(Preparation method)
No. 1 to 15 were heated to about 70 ° C. and dissolved uniformly (part A). Next, no. 16-19
Was heated to about 70 ° C. and dissolved uniformly (part B). To Part A, Part B was added with stirring and emulsified, and then cooled.

This emollient cream was a cream excellent in the effect of imparting a moist feeling.

Example 86 Massage Cream A massage cream having the following formulation was prepared using Compound F obtained in Example 6.

Component Blending amount (% by weight)
--------------------------------
1 Compound F 4.00 obtained in Example 6
2 Macadamia nut fatty acid phytosteryl 8.00
3 Glyceryl stearate (SE) 2.00
4 Polysorbate 60 1.80
5 Sorbitan stearate 1.00
6 Polyglyceryl stearate-10 0.50
7 Cholesterol 0.20
8 Dimethicone (10cs) 1.00
9 Myristyl alcohol 1.00
10 Stearic acid 1.00
11 Stearyl alcohol 0.50
12 Behenyl alcohol 0.50
13 Hydrogenated palm oil 9.00
14 Tocopherol 0.10
15 Isostearyl palmitate 2.00
16 Cetyl octanoate 15.00
17 Ethylparaben 0.20
18 Phenoxyethanol 0.20
19 Methylparaben 0.10
20 1,3-butylene glycol 10.00
21 Glycerin 3.00
22 Purified water 38.90
--------------------------------

(Preparation method)
No. 1 to 17 were heated to about 70 ° C. and dissolved uniformly (part A). Next, no. 18-22
Was heated to about 70 ° C. and dissolved uniformly (part B). To Part A, Part B was added with stirring and emulsified, and then cooled.

This massage cream was a cream having a high massage effect and excellent moisturizing effect.

Example 87 Emulsion An emulsion having the following formulation was prepared using Compound D obtained in Example 4.

Component Blending amount (% by weight)
--------------------------------
1 Compound D obtained in Example 4 2.50
2 Sorbitan stearate 0.50
3 PEG-10 stearate 0.50
4 Polysorbate 60 0.50
5 Cetyl octanoate 3.70
6 Cetanol 1.20
7 Dimethicone (10cs) 1.00
8 Ethylparaben 0.10
9 1,3-butylene glycol 3.00
10 Glycerin 1.00
11 Phenoxyethanol 0.20
12 Methylparaben 0.15
13 Citric acid 0.01
14 Na citrate 0.09
15 Xanthan gum 0.10
16 Carbomer 0.15
17 Hydroxide K 0.06
18 Purified water 85.24
--------------------------------

(Preparation method)
No. 15 for some No. 15 18 and stirred to give a viscous liquid (Part A). No. 16 is a part of No.16. No. 18 after stirring, 17 was added to obtain a viscous liquid (Part B). Next, no. 1 to 8 were heated to about 70 ° C. and dissolved (part C). No. 9-14, remaining No
. 18 was heated to about 70 ° C. and dissolved (part D). Part D was added to part C with stirring and emulsified, then cooled to about 50 ° C., part A and part B were added and stirred until uniform.

This emulsion was excellent in the effect of imparting a moist feeling.

Example 88 Lip Gloss Using the compound B obtained in Example 2, a lip gloss having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound B 7.70 obtained in Example 2
2 LUSPLAN DD-DA7 (Nippon Seika) 17.00
3 Cetyl octanoate 33.00
4 Dextrin palmitate 7.00
5 Mica 9.00
6 Sulfuric acid Ba 25.00
7 Red 104 (1) 0.50
8 Yellow 203 0.80
--------------------------------

(Preparation method)
No. No. 4 In addition to a part of 3, it was heated to about 100-110 ° C. and dissolved uniformly (A
Part). Next, no. 1, 2 and the remaining No. 3, no. 5-8 were added and it mixed by the roll mill (B part). Part A and part B were added, heated to about 60 ° C., stirred and mixed uniformly, then filled into a mold and rapidly cooled.

This lip gloss was glossy, fresh and had high adhesion.

Example 89 Foundation Using the compound C obtained in Example 3, a foundation having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound C 6.00 obtained in Example 3
2 Mica 39.50
3 Talc 24.00
4 Titanium oxide 20.00
5 Iron oxide 1.90
6 Cyclomethicone 3.50
7 Trimethylsiloxysilicic acid 1.50
8 Octyl methoxycinnamate 1.00
9 Dimethicone (10cs) 2.00
10 Tocopherol 0.20
11 Phenoxyethanol 0.40
--------------------------------

(Preparation method)
No. 1 to 11 were mixed uniformly.

This foundation had excellent color development and a moist feel.

Example 90 Liquid Foundation Using the compound A obtained in Example 1, a liquid foundation having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound A 5.00 obtained in Example 1
2 Glyceryl stearate (SE) 1.00
3 Stearic acid PG (SE) 1.00
4 Cetyl octanoate 6.00
5 Tocopherol 0.10
6 Propylparaben 0.10
7 Titanium oxide / iron oxide mixture 18.00
(Toyo Pigment Co., Ltd. FDP-W-007)
8 Mica 7.00
9 Trimethylsiloxysilicate 3.00
10 Cyclomethicone 7.00
11 Phenylmethicone 5.00
12 Cellulose gum 0.10
13 Xanthan gum 0.20
14 1,3-butylene glycol 5.00
15 Methylparaben 0.20
16 Purified water 41.30
--------------------------------

(Preparation method)
No. 12 is a part of No. 12. 16 and stirred to give a viscous liquid (Part A). No. 13 for some No. 13 16 and stirred to give a viscous liquid (Part B). Next, no. 1-6, 9-1
1 was added and heated to about 70 ° C. to dissolve (Part C). No. 7, 8, 14, 15, remaining N
o. 16 was heated to about 70 ° C. and dissolved (part D). Part D was added to part C with stirring and emulsified, then cooled to about 50 ° C., part A and part B were added and stirred until uniform.

This liquid foundation was excellent in usability and adhesion to the skin.

Example 91 Pasty lipstick Using the compound F obtained in Example 6 and the compound G obtained in Example 7, a pasty lipstick having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound F 40.00 obtained in Example 6
2 Compound G 30.00 obtained in Example 7
3 Organically modified clay mineral 2.00
(Benton 38 from National Head)
4 Pigment Appropriate amount
5 Liquid paraffin Amount that totals 100 -------------------------------

(Preparation method)
No. 1-5 are heated and mixed uniformly.

This lipstick was excellent in terms of gloss and odor, and had a smooth and sticky feeling when applied.

Example 92 Treatment Using the compound B obtained in Example 2, a treatment having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound B obtained in Example 2 1.00
2 Cetanol 5.00
3 Oleyl alcohol 1.00
4 Behentrimonium chloride (80%) 2.40
5 Distearyldimonium chloride (75%) 0.80
6 Glyceryl stearate 1.00
7 Methylparaben 0.10
8 Citric acid 0.10
9 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1 to 6 were heated to about 80 ° C. and dissolved uniformly (part A). In another container 7-9
And heated to about 80 ° C. and dissolved uniformly (part B). B part was gradually added to part A and mixed uniformly.

This treatment was a treatment capable of keeping the moisture of the hair and giving the hair a gloss, moist feeling, and a smooth feel.

Example 93 Treatment A treatment having the following formulation was prepared using Compound E obtained in Example 5.

Component Blending amount (% by weight)
--------------------------------
1 Compound E 1.00 obtained in Example 5
2 Cetanol 5.00
3 Oleyl alcohol 1.00
4 Behentrimonium chloride (80%) 2.40
5 Distearyldimonium chloride (75%) 0.80
6 Glyceryl stearate 1.00
7 Dimethicone (10000cs) 0.20
8 Aminopropyl dimethicone 0.10
9 Methylparaben 0.10
10 Citric acid 0.10
11 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1 to 8 were heated to about 80 ° C. and dissolved uniformly (part A). In another container 9-1
1 was heated to about 80 ° C. and dissolved uniformly (part B). B part was gradually added to part A and mixed uniformly.

This treatment was a treatment capable of keeping the moisture of the hair and giving the hair a gloss, moist feeling, and a smooth feel.

Example 94 Leave-On Treatment Using the compound A obtained in Example 1, a leave-on treatment (for hair) having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound A 0.50 obtained in Example 1
2 Diethyl sebacate 1.00
3 Myristyl alcohol 5.00
4 Behenyl alcohol 1.00
5 Oleyl alcohol 1.00
6 Dimethylpropylamide stearate 2.00
7 Cocoamphoacetate Na (30%) 2.00
8 Glyceryl stearate 0.40
9 Myristic acid 0.60
10 Phenoxyethanol 0.40
11 Lactic acid 0.60
12 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1 to 10 were heated to about 80 ° C. and dissolved (part A). In another container 11, 12
And heated to about 80 ° C. to dissolve (Part B). Part B was gradually added to part A and mixed uniformly.

This leave-on treatment (for hair) was able to impart softness and slipperiness to the hair with a light touch. Moreover, stability was also favorable.

Example 95 Leave-On Treatment Using the compound D obtained in Example 4, a leave-on treatment (for hair) having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound D 0.50 obtained in Example 4
2 Isopropyl palmitate 4.00
3 Cetanol 5.00
4 Steertrimonium chloride (63%) 3.20
5 Behentrimonium chloride (80%) 1.00
6 Squalane 1.00
7 Glycerin 1.00
8 Methylparaben 0.10
9 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1 to 7 were heated to about 80 ° C. and dissolved (part A). In another container 8, 9 was taken and heated to about 80 ° C. to dissolve (Part B). Part B was gradually added to part A and mixed uniformly.

This leave-on treatment (for hair) was able to impart softness and slipperiness to the hair with a light touch. Moreover, stability was also favorable.

Example 96 Hair Essence Using compound A obtained in Example 1, a hair essence having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound A 0.50 obtained in Example 1
2 Diethyl sebacate 1.00
3 Cetanol 1.00
4 Steartrimonium chloride (63%) 0.80
5 Zicococomonium chloride (75%) 2.80
6 Solveste tetraoleate-60 1.00
7 PEG-40 hydrogenated castor oil 0.20
8 Methylparaben 0.10
9 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 1 to 7 were heated to about 80 ° C. and dissolved (part A). In another container 8, 9 was taken and heated to about 80 ° C. to dissolve (Part B). Part B was gradually added to part A and mixed uniformly.

This hair essence was refreshing and non-sticky and could give the hair a soft and slippery feel.

Example 97 Rinse-in shampoo Using the compound F obtained in Example 6, a rinse-in shampoo having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound F 1.00 obtained in Example 6
2 Cocamidopropyl betaine (30%) 20.00
3 Lauryl sulfate TEA (40%) 15.00
4 Cocamide DEA 2.00
5 Cocoa glutamate TEA (30%) 30.00
6 Ethylene glycol distearate 1.20
7 Dimethicone (10000cs) 0.10
8 Aminopropyl dimethicone 0.10
9 Polyquaternium-10 1.60
10 Polyquaternium-7 1.60
11 Stearyl trimonium bromide (70%) 0.60
12 Phenoxyethanol 0.20
13 Methylparaben 0.20
14 Sodium benzoate 0.40
15 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. 9 to 11 and 15 were heated to about 80 ° C. and mixed with stirring. Next, no. Add 3 and stir,
No. Add 1, 2, 4 to 8 and stir and mix until uniform. 12-14 was added and dissolved.

This rinse-in shampoo was not sticky, gave a moist feeling to the hair, and was able to give a smooth fingering.

Example 98 Anti-aging cream Using the compound B obtained in Example 2, an anti-aging cream having the following formulation was prepared.

Component Blending amount (% by weight)
----------------------------------
A
Compound B 15.00 obtained in Example 2
Cetyl octanoate 7.00
Batyl isostearate 2.00
PEG-60 glyceryl isostearate 1.50
Hydrogenated palm oil 3.70
Ceramide 2 0.10
Retinol 0.10
Oil-soluble chamomile extract 0.10
Ethylparaben 0.20
Stearyl alcohol 3.50
Glyceryl stearate (SE) 1.00
Steerless-6 1.50
Distearic acid PEG-8 1.00
Cetanol 1.00
Dimethicone 1.00
Cetyl dimethicone copolyol 0.50
Tocopherol 0.20
B
Nishi Healing Extract 0.05
C
Arbutin 0.50
Ascorbic acid 2-O-glucoside 0.50
EDTA-3Na 0.10
Polyglutamic acid (Ichimaru Falcos, Bio PGA solution) 0.10
Glycerin 4.00
Bisulfite Na 0.05
Methylparaben 0.10
Phenoxyethanol 0.10
BG 6.00
Hydroxide K Appropriate amount of purified water Total amount of 100 ----------------------------------

(Production method)
A was heated to about 80 ° C. and dissolved uniformly (part A). C was heated to about 80 ° C. and dissolved (part C). While stirring with a homomixer at about 80 ° C., part C was gradually added to part A, mixed uniformly after emulsification, cooled to about 40 ° C., B was added and mixed uniformly.

This cream had good elongation and was excellent in the effect of imparting a moist feeling.

Example 99 Hair restorer Using compound B obtained in Example 2, a hair restorer having the following formulation was prepared.

Component Blending amount (% by weight)
----------------------------------
Compound B 0.05 obtained in Example 2 0.05
Diethyl sebacate 0.45
Menthol 0.10
Pepper tincture 0.50
Assembly extract 2.00
Ethanol 30.00
Preservative Appropriate amount of perfume Appropriate amount PPG-6 Decyltetradeceth-30 0.30
Purified water Total amount of 100 ----------------------------------

(Production method)
Each component was stirred and mixed uniformly.

This hair restorer was able to prevent hair loss, dandruff and itching.

Example 100 Acid hair dye (hair manicure)
Using the compound D obtained in Example 4, an acidic hair dye having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Compound D 2.00 obtained in Example 4
2 N-methylpyrrolidone 15.00
3 Benzyl alcohol 8.00
4 Citric acid 1.00
5 Brown 201 0.13
6 Black 401 0.05
7 Purified water Total amount of 100 --------------------------------

(Preparation method)
Each component was mixed uniformly.

This acidic hair dye was an acidic hair dye capable of imparting a good feel such as flexibility and slipperiness to the hair by treating the hair.

Example 101 Perm Agent A perm agent of the following formulation was prepared using Compound G obtained in Example 7.

(1 liquid)
Component Blending amount (% by weight)
--------------------------------
1 Compound G 1.00 obtained in Example 7
2 Polyquaternium-22 2.00
3 Monoethanolamine 1.00
4 Ammonia water (28%) 1.00
5 PEG-50 hydrogenated castor oil 0.20
6 Ammonium bicarbonate 2.00
7 Phosphoric acid 2Na 0.50
8 Ammonium thioglycolate aqueous solution (50%) 11.50
9 Cysteine 1.50
10 EDTA-4Na 0.15
11 Hydroxide Na 0.25
12 Polyquaternium-10 0.10
13 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. No. 13 in the majority of No. 13 11 is dissolved and then No. 11 is dissolved. No. 12 was added in small portions and dissolved. 8-10 were added and dissolved (part A). No. in a separate container. Take the rest of 13 6 and 7 were added, and it heated and dissolved (part B). No. in a separate container. Add 1-5, about 5
Warm to 0 ° C. and dissolve (part C). Part B was added to part A and mixed uniformly, then part C was gradually added and mixed uniformly.

(2 liquids)
Component Blending amount (% by weight)
--------------------------------
1 Compound G 0.50 obtained in Example 7
2 Sodium benzoate 0.20
3 Edetic acid 2Na 0.10
4 Diammonium phosphate 0.10
5 Emmacol TS-703 (Sanei Chemical) 2.00
6 Stearyltrimonium chloride (50%) 2.00
7 Na bromate 10.00
8 Emmacol NZ (Sanei Chemical) 4.00
9 Ores-20 3.00
10 Purified water Total amount of 100 --------------------------------

(Preparation method)
No. Take most of 10 and heat to about 60 ° C. No. 1 to 3 were added and dissolved.
4 was added and dissolved. Then No. Add 5 and 6 and heat, dissolve and slowly cool to 40 ° C
No. 7-9 was added and made uniform. The remaining No. 10 was added, mixed uniformly and cooled.

This permanent agent was a permanent agent that gave hair a feeling of slipping and softness when applied to the hair.

Example 102 Sunscreen Cosmetic Using the compound D obtained in Example 4, a sunscreen cosmetic having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
A
Quaternium-18 Hectorite 1.00
B
Cyclomethicone 13.70
Diphenyl dimethicone 7.00
Compound D 2.00 obtained in Example 4
Dimethicone copolyol 5.50
YOFCO MAS (Nippon Seika) 1.00
C
Silicone-treated fine particle titanium oxide 3.90
Silicone-treated zinc oxide 2.10
D
Stearic acid Al 0.70
Hydroxide Al 0.50
Isononyl isononanoate 2.50
Isodecyl neopentanoate 2.50
E
Trimethylsiloxysilicate 1.20
Dimethicone 0.80
Meticon 0.10
Stearyl glycyrrhetinate 0.02
Sorbitan sesquioleate 2.00
Tocopherol 0.02
F
Na chloride 1.00
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------

(Production method)
Add A to B and stir. Further, C is added and dispersed using a roller mill. D is heated and melted and added to the mixture of A, B, and C, and E is further added to about 70 ° C. F is warmed and emulsified gradually with stirring into a mixture of A to E. Cool with stirring, stop stirring at 40-35 ° C. and let stand.

This sunscreen cosmetic did not float white and had a high UV protection effect.

Example 103 Bath agent (bubble bath)
Using the compound B obtained in Example 2, a bath preparation having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
A
(C12,13) Palace-3 sulfate Na 5.00
Cocamide DEA 2.00
Sulfosuccinic acid (C12-14) Palace-2Na 2.00
1,3-butylene glycol 2.00
Compound B obtained in Example 2 1.00
PEG-20 glyceryl triisostearate 1.00
B
Citric acid 0.05
Sodium benzoate 0.20
Blue No.1 Trace yellow No.4 Trace C
Purified water Total amount of 100

--------------------------------

(Production method)
A is dissolved in a part of C to make it uniform. Add the remaining C and B and knead well.

This bath preparation had effects such as moisturizing skin and improving skin gloss.

Example 104 Liquid Face Wash Using the compounds A to G obtained in Examples 1 to 7, a liquid face wash having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 Lauroyl sarcosine Na 12.00
2 Myristoyl methyl taurine Na 2.00
3 Isethionate Na 1.00
4 Polyglyceryl laurate-6 2.00
5 Cocamide DEA 2.00
6 Sorbitol 8.00
7 PEG-30 4.00
8 1,3-butylene glycol 8.00
9 Compounds obtained in Examples 1-7 2.00
10 Glycerin 5.00
11 Phenoxyethanol 0.80
12 (HEMA glucoside / ethyltrimonium methacrylate methacrylate)
Copolymer (10%) (Nippon Seika) 1.00
13 Purified water Total amount of 100 --------------------------------

(Production method)
No. 3 and 10 were heated to about 80 ° C. and dissolved (part A). No. in part A 1, 2, 4-9,
11-13 were added, and it heated to about 80 degreeC, and was made to melt | dissolve uniformly, and it cooled. No. The prescription excluding only 9 was blank.

Ten panelists evaluated the skin feel after using the face wash. The evaluation was performed for two items, a slippery feeling and a moist feeling. The results are shown below. In the table, ◎: Reply that 8 or more out of 10 people are better than blank, ○: Reply that 6 or more out of 10 people are better than blank, △: Reply that 4 or more out of 10 people are better than blank, X: Less than 4 out of 10 responded that it was better than blank. As shown below, it can be seen that the face wash formulated with the product of the present invention can give the skin a moist and slippery feeling as compared with the non-formulated product, and is also excellent as a fat-adding agent.

Compound name Smooth feeling Moist feeling -------------------------------
Compound A ◎ ○
Compound B ◎ ◎
Compound C ◎ ◎
Compound D ○ ○
Compound E ○ ◎
Compound F ○ ○ ○
Compound G ◎ ○
-------------------------------

Example 105 Body Shampoo Using the compounds A to G obtained in Examples 1 to 7, a body shampoo having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
1 (HEMA glucoside / ethyltrimonium methacrylate methacrylate)
Copolymer (10%) (Nippon Seika) 2.00
2 Cocoyl Methyl Taurine Na 10.00
3 Lauroyl hydrolyzed silk Na 6.00
4 Lauroylmethylalanine Na 10.00
5 Cocoamphoacetate Na (30%) 4.00
6 Cocamidopropyl betaine (30%) 10.00
7 Cocamide DEA 3.00
8 Compound 3.00 obtained in Examples 1-7
9 1,3-butylene glycol 5.00
10 Methylparaben 0.20
11 Purified water Total amount of 100 --------------------------------

(Production method)
No. 1 and a part of No. 11 were heated at about 80 ° C. and mixed uniformly (part A). No. 2
~ No. 10. The remaining 11 was heated at about 80 ° C. and mixed uniformly (Part B). While stirring, part A was gradually added to part B and mixed uniformly. No. The prescription excluding only 8 was used as a blank.

Ten panelists evaluated the skin feel after using the body shampoo. The evaluation was performed for two items, a slippery feeling and a moist feeling. The results are shown below. In the table, ◎: Reply that 8 or more out of 10 people are better than blank, ○: Reply that 6 or more out of 10 people are better than blank, △: Reply that 4 or more out of 10 people are better than blank, X: Less than 4 out of 10 responded that it was better than blank. As shown below, it can be seen that the body shampoo containing the product of the present invention can give the skin a moist feeling and a smooth and slippery feeling as compared with the non-formulated product, and is also excellent as a fat-adding agent.

Compound name Smooth feeling Moist feeling -------------------------------
Compound A ◎ ○
Compound B ◎ ◎
Compound C ◎ ◎
Compound D ◎ ○
Compound E ◎ ◎
Compound F ○ ◎
Compound G ◎ ○
-------------------------------

Example 106 Body Shampoo A body shampoo having the following formulation was prepared using the compounds A to G obtained in Examples 1 to 7.

Component Blending amount (% by weight)
--------------------------------
1 (HEMA glucoside / ethyltrimonium methacrylate methacrylate)
Copolymer (10%) (Nippon Seika) 2.00
2 Lauryl phosphate 20.00
3 Cocamidopropyl betaine (30%) 10.00
4 Lauroylmethylalanine Na 6.00
5 Cocamide DEA 2.00
6 Compounds obtained in Examples 1-7 2.00
7 Distearic acid PEG-150 1.00
8 Glycerin 4.00
9 Sodium benzoate 0.40
10 Phenoxyethanol 0.20
11 Purified water Total amount of 100 --------------------------------

(Production method)
No. 1 and a part of No. 11 were heated at about 80 ° C. and mixed uniformly (part A). No. 2
~ No. 10. The remaining 11 was heated at about 80 ° C. and mixed uniformly (Part B). While stirring, part A was gradually added to part B and mixed uniformly. No. The formulation excluding only 6 was used as a blank.

Ten panelists evaluated the skin feel after using the body shampoo. The evaluation was performed for two items, a slippery feeling and a moist feeling. The results are shown below. In the table, ◎: Reply that 8 or more out of 10 people are better than blank, ○: Reply that 6 or more out of 10 people are better than blank, △: Reply that 4 or more out of 10 people are better than blank, X: Less than 4 out of 10 responded that it was better than blank. As shown below, it can be seen that the body shampoo containing the product of the present invention can give the skin a moist feeling and a smooth and slippery feeling as compared with the non-formulated product, and is also excellent as a fat-adding agent.

Compound name Smooth feeling Moist feeling -------------------------------
Compound A ◎ ○
Compound B ◎ ◎
Compound C ◎ ◎
Compound D ○ ○
Compound E ◎ ◎
Compound F ○ ◎
Compound G ○ ○
-------------------------------

Example 107 Face Wash Liquid Using the compounds A to G obtained in Examples 1 to 7, a face wash liquid having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
Lipidure PMB (Japanese fat) 1.00
Compounds obtained in Examples 1-7 1.00
Dipotassium glycyrrhizinate 0.05
Palm oil fatty acid diethanolamide 4.00
N-coconut oil fatty acid acyl-L-glutamic acid triethanolamine 1.50
Palm oil fatty acid amidopropyl betaine 8.10
N-coconut oil fatty acid acyl-DL-alanine triethanolamine 1.50
Preservative Appropriate amount Sodium monohydrogen phosphate anhydrous 1.00
Citric acid 0.15
Purified water Total amount of 100 --------------------------------

(Production method)
Warm to 40-50 ° C and stir to homogenize. Moreover, the formulation except only the compounds obtained in Examples 1 to 7 was used as a blank.

Ten panelists evaluated the skin feel after using the face-washing liquid. Evaluation is slippery,
I went for two items of moist feeling. The results are shown below. In the table, ◎: 8 out of 10 people
More than one person answered that it was better than blank, ○: More than 6 out of 10 answered that it was better than blank, △
: 4 or more out of 10 responded that it was better than blank, x: less than 4 out of 10 answered that it was better than blank. As shown below, the facial cleansing liquid containing the product of the present invention can give the skin a moist feeling and a smooth slipperiness compared to the non-formulated product, and is also excellent as a fat-fitting agent.

Compound name Smooth feeling Moist feeling -------------------------------
Compound A ○ ○
Compound B ◎ ◎
Compound C ○ ◎
Compound D ○ ○
Compound E ○ ◎
Compound F ○ ◎
Compound G ◎ ○
-------------------------------

Example 108 Facial Cleansing Foam Using the compounds A to G obtained in Examples 1 to 7, facial cleansing foams having the following formulation were prepared.

Component Blending amount (% by weight)
--------------------------------
1 (coconut fatty acid / hydrogenated tallow fatty acid) glutamic acid Na 20.00
2 1,3-butylene glycol 14.00
3 Plandool-H (Nippon Seika) 1.00
4 PEG-8 5.00
5 PEG-30 10.00
6 Lauric acid diethanolamide 2.00
7 Propylparaben 0.10
8 Methylparaben 0.20
9 Lipidure PMB (Japanese fats and oils) 1.00
10 Crystalline cellulose 10.00
11 Compounds obtained in Examples 1-7 5.00
12 Tocopherol 0.20
13 Purified water Total amount of 100 --------------------------------

(Production method)
No. 1 to 8 and 11 are heated to about 80 ° C. and dissolved. No. after dissolution Add 12 and 13 and dissolve. While stirring at about 60 ° C., no. Add 9, 10 and cool to about 40 ° C. No. The prescription excluding only 11 was used as a blank.

Ten panelists evaluated the skin feel after using the facial cleansing foam. Evaluation is slippery,
I went for two items of moist feeling. The results are shown below. In the table, ◎: 8 out of 10 people
More than one person answered that it was better than blank, ○: More than 6 out of 10 answered that it was better than blank, △
: 4 or more out of 10 responded that it was better than blank, x: less than 4 out of 10 answered that it was better than blank. As shown below, the facial cleansing foam blended with the product of the present invention can give the skin a moist and slippery feeling compared to the unblended product, and is also excellent as a fat-fitting agent.

Compound name Smooth feeling Moist feeling -------------------------------
Compound A ◎ ◎
Compound B ◎ ◎
Compound C ○ ◎
Compound D ○ ○
Compound E ○ ◎
Compound F ○ ◎
Compound G ◎ ○
-------------------------------

Example 109 Soap A soap having the following formulation was prepared using the compounds A to G obtained in Examples 1 to 7.

Component Blending amount (% by weight)
--------------------------------
Soken base Amount to be 100 in total Lauric acid 5.00
1,3-butylene glycol 3.00
Compounds obtained in Examples 1-7 5.00
Plandool-H (Nippon Seika) 0.05
Titanium oxide 1.00
Etidronic acid 0.10
Edetate 0.10
Yellow No. 205 Trace ---------------------------------

(Production method)
All components are dissolved by heating to 80 ° C., cooled with stirring, poured into molds and left to stand. Moreover, the formulation except only the compounds obtained in Examples 1 to 7 was used as a blank.

Ten panelists evaluated the skin feel after using the soap. The evaluation was performed for two items, a slippery feeling and a moist feeling. The results are shown below. In the table, ◎: Reply that 8 or more out of 10 people are better than blank, ○: Reply that 6 or more out of 10 people are better than blank, △: Reply that 4 or more out of 10 people are better than blank, X: Less than 4 out of 10 responded that it was better than blank. As shown below, it can be seen that the soap blended with the product of the present invention can give the skin a moist and slippery feeling as compared with the unblended product, and is also excellent as a fat-adding agent.

Compound name Smooth feeling Moist feeling -------------------------------
Compound A ◎ ○
Compound B ◎ ◎
Compound C ○ ◎
Compound D ◎ ○
Compound E ○ ◎
Compound F ○ ◎
Compound G ◎ ◎
-------------------------------

Example 110 Using the compounds A to G obtained in the face wash Examples 1 to 7, a face wash having the following formulation was prepared.

Component Blending amount (% by weight)
--------------------------------
A
Compounds obtained in Examples 1-7 0.50
Plandool-H (Nippon Seika) 0.20
Jojoba oil 0.10
Squalane 0.10
Cocamide DEA 2.00
Lauramide DEA 3.00
Tocopherol 0.20
Propylparaben 0.10
B
Distearate glycol 1.00
Lauroylmethylalanine Na (30%) 10.00
Coconut fatty acid K, myristic acid K (40%) 40.00
BG 3.50
1,5-pentanediol 0.50
1,2-hexanediol 0.30
PEG-20 5.00
PEG-400 5.00
Citric acid 0.50
Methylparaben 0.20
Cetealess 60 myristyl glycol 2.00
Purified water Total amount of 100 --------------------------------

(Production method)
A was heated to about 80 ° C. and dissolved. B was heated to about 80 ° C. and dissolved. B was added to A with stirring and emulsified, and then cooled to about 40 ° C. Moreover, the formulation except only the compounds obtained in Examples 1 to 7 was used as a blank.

Ten panelists evaluated the skin feel after using the face wash. The evaluation was performed for two items, a slippery feeling and a moist feeling. The results are shown below. In the table, ◎: 8 or more out of 10 responded that better than blank, ○: 6 or more out of 10 responded that better than blank, △: 10
Four or more of the respondents answered that they were better than the blank, and X: less than 4 out of 10 responded that they were better than the blank. As shown below, the face wash formulated with the product of the present invention has a moist feeling on the skin, compared to the non-formulated product.
It can be seen that it can provide a slippery slipperiness and is also excellent as a fat-adding agent.

Compound name Smooth feeling Moist feeling -------------------------------
Compound A ◎ ◎
Compound B ◎ ◎
Compound C ○ ◎
Compound D ○ ○
Compound E ◎ ◎
Compound F ○ ◎
Compound G ◎ ◎
-------------------------------

According to the present invention, moisturizing agent with sufficient moisture retention ability, few touching problems, high safety moisturizing agent, high moisturizing function, and excellent touch and safety. And skin external preparation can be obtained.

Claims (4)

Moisturizing containing a divalent carboxylic acid one or more selected from the following (A), of poly ethylene glycol having a number average molecular weight from 285 to 3000, the oligomeric ester having a weight average molecular weight of less than 1500 10,000 Agent.
(A): Suberic acid, azelaic acid, sebacic acid, 2,4-diethylpentanedioic acid, undecanedioic acid, dodecanedioic acid, tridecanedioic acid, tetradecanedioic acid, pentadecanedioic acid, hexadecanedioic acid, octadecanedioic acid, Eicosane diacid, dimethyl eicosane diacid, cyclohexane dicarboxylic acid, dimer acid, hydrogenated dimer acid The humectant according to claim 1, wherein at least one of the divalent carboxylic acids or at least one of the divalent carboxylic acids is cyclohexanedicarboxylic acid. The humectant according to claim 1, wherein at least one of the divalent carboxylic acids is one or more of hydrogenated dimer acids. Cosmetics or skin external preparations containing the moisturizer according to any one of claims 1 to 3 , excluding a hair styling agent.