JP5690074B2 - Cosmetics containing ceramide derivatives - Google Patents
Cosmetics containing ceramide derivatives Download PDFInfo
- Publication number
- JP5690074B2 JP5690074B2 JP2010065694A JP2010065694A JP5690074B2 JP 5690074 B2 JP5690074 B2 JP 5690074B2 JP 2010065694 A JP2010065694 A JP 2010065694A JP 2010065694 A JP2010065694 A JP 2010065694A JP 5690074 B2 JP5690074 B2 JP 5690074B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- extract
- oil
- fatty acid
- ceramide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000002537 cosmetic Substances 0.000 title claims description 68
- 150000001783 ceramides Chemical class 0.000 title claims description 48
- -1 alkyl quaternary ammonium salts Chemical class 0.000 claims description 191
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 91
- 229930195729 fatty acid Natural products 0.000 claims description 91
- 239000000194 fatty acid Substances 0.000 claims description 91
- 150000004665 fatty acids Chemical class 0.000 claims description 54
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
- 229940099417 ceramide 2 Drugs 0.000 claims description 15
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- 239000004094 surface-active agent Substances 0.000 claims description 13
- 150000003904 phospholipids Chemical class 0.000 claims description 9
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims description 8
- 229940044176 ceramide 3 Drugs 0.000 claims description 6
- 229930182558 Sterol Natural products 0.000 claims description 5
- 150000003432 sterols Chemical class 0.000 claims description 5
- 235000003702 sterols Nutrition 0.000 claims description 5
- 239000012736 aqueous medium Substances 0.000 claims description 4
- 229920005862 polyol Polymers 0.000 claims description 4
- 150000003077 polyols Chemical class 0.000 claims description 4
- 239000000284 extract Substances 0.000 description 162
- 210000004209 hair Anatomy 0.000 description 48
- 239000002253 acid Substances 0.000 description 47
- 229920001296 polysiloxane Polymers 0.000 description 40
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 38
- 210000003491 skin Anatomy 0.000 description 35
- 235000002639 sodium chloride Nutrition 0.000 description 34
- 239000000843 powder Substances 0.000 description 33
- 239000000203 mixture Substances 0.000 description 31
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 30
- 230000015572 biosynthetic process Effects 0.000 description 30
- 239000003921 oil Substances 0.000 description 30
- 238000003786 synthesis reaction Methods 0.000 description 30
- 239000003795 chemical substances by application Substances 0.000 description 29
- 235000019198 oils Nutrition 0.000 description 29
- 239000006210 lotion Substances 0.000 description 27
- 150000003839 salts Chemical class 0.000 description 27
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 26
- 150000001875 compounds Chemical class 0.000 description 26
- 239000006071 cream Substances 0.000 description 26
- 239000011734 sodium Substances 0.000 description 26
- 235000019388 lanolin Nutrition 0.000 description 25
- 239000004166 Lanolin Substances 0.000 description 24
- 229940106189 ceramide Drugs 0.000 description 24
- 229920001577 copolymer Polymers 0.000 description 24
- 229940039717 lanolin Drugs 0.000 description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 21
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 20
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
- 238000009472 formulation Methods 0.000 description 18
- 239000008213 purified water Substances 0.000 description 17
- 229910052708 sodium Inorganic materials 0.000 description 17
- 235000010323 ascorbic acid Nutrition 0.000 description 16
- 229960005070 ascorbic acid Drugs 0.000 description 16
- 239000011668 ascorbic acid Substances 0.000 description 16
- 239000004359 castor oil Substances 0.000 description 16
- 235000019438 castor oil Nutrition 0.000 description 16
- 239000000539 dimer Substances 0.000 description 16
- 239000004205 dimethyl polysiloxane Substances 0.000 description 16
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 16
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 16
- 238000002156 mixing Methods 0.000 description 16
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 15
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 15
- 229910019142 PO4 Inorganic materials 0.000 description 14
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 14
- 229940008099 dimethicone Drugs 0.000 description 14
- 239000006185 dispersion Substances 0.000 description 14
- 239000000839 emulsion Substances 0.000 description 14
- 150000002148 esters Chemical class 0.000 description 14
- 235000021317 phosphate Nutrition 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 14
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 13
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 13
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 229920000642 polymer Polymers 0.000 description 12
- 108090000765 processed proteins & peptides Proteins 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 11
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 11
- 229960002216 methylparaben Drugs 0.000 description 11
- 239000010452 phosphate Substances 0.000 description 11
- 229920006395 saturated elastomer Polymers 0.000 description 11
- 239000002453 shampoo Substances 0.000 description 11
- 239000000344 soap Substances 0.000 description 11
- 238000011282 treatment Methods 0.000 description 11
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 10
- 239000000049 pigment Substances 0.000 description 10
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 10
- HQHCYKULIHKCEB-UHFFFAOYSA-N tetradecanedioic acid Chemical compound OC(=O)CCCCCCCCCCCCC(O)=O HQHCYKULIHKCEB-UHFFFAOYSA-N 0.000 description 10
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 9
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 9
- 229940022663 acetate Drugs 0.000 description 9
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 9
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 9
- 235000011187 glycerol Nutrition 0.000 description 9
- 150000002430 hydrocarbons Chemical group 0.000 description 9
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000000600 sorbitol Substances 0.000 description 9
- 235000010356 sorbitol Nutrition 0.000 description 9
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 9
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 8
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 8
- 235000019864 coconut oil Nutrition 0.000 description 8
- 239000003240 coconut oil Substances 0.000 description 8
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 8
- 230000003020 moisturizing effect Effects 0.000 description 8
- 229960005323 phenoxyethanol Drugs 0.000 description 8
- 229920001451 polypropylene glycol Polymers 0.000 description 8
- 229930195734 saturated hydrocarbon Natural products 0.000 description 8
- 159000000000 sodium salts Chemical class 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 235000010384 tocopherol Nutrition 0.000 description 8
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- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 8
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 8
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 7
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 7
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Landscapes
- Cosmetics (AREA)
Description
本発明は、下記の一般式(1)で示されるセラミド類に含まれる水酸基の一部又は全てが、炭素数4〜22の直鎖又は分岐鎖を有する脂肪酸でアシル化されたセラミド誘導体を含有する化粧料に関する。
R1:1個以上の水酸基で置換されていてもよい炭素数7〜31の直鎖又は分岐鎖の飽和又は不飽和炭化水素基、若しくは、R4−COO−R3−(R3及びR4は水酸基で置換されていてもよい炭素数7〜31の直鎖又は分岐鎖の飽和又は不飽和炭化水素基を示す)
R2:1個以上の水酸基で置換されていてもよい炭素数7〜27の直鎖又は分岐鎖の飽和又は不飽和炭化水素基
A:下記一般式(2)から選ばれる基
R1: A linear or branched saturated or unsaturated hydrocarbon group having 7 to 31 carbon atoms which may be substituted with one or more hydroxyl groups, or R4-COO-R3- (R3 and R4 are substituted with hydroxyl groups) A C7-31 linear or branched saturated or unsaturated hydrocarbon group which may be
R2: a linear or branched saturated or unsaturated hydrocarbon group having 7 to 27 carbon atoms which may be substituted with one or more hydroxyl groups A: a group selected from the following general formula (2)
セラミドは角層中の細胞間脂質の主成分として存在し、脂肪酸、コレステロールと共にラメラ構造を形成することで、外界からの刺激防御および皮膚内部からの水分蒸散を防ぐバリア機能、皮膚保湿機能といった重要な役割を果たしている。また、毛髪においても細胞膜複合体の構成成分として存在しており、キューティクルとコルテックスの接着に貢献していることが知られている。このようにセラミドは皮膚または毛髪化粧料における有用な成分として従来から広く知られているが、高融点、高結晶性であり、油剤への溶解性も乏しいため、皮膚及び毛髪化粧料へ配合が難しく、また、配合できても経時で析出するなど安定性の面で問題がある。このような問題を改善するものとして、様々な成分と併用する手法が開示されているが未だ十分とは言えない(例えば特許文献1〜3)。 Ceramide exists as the main component of intercellular lipids in the stratum corneum, and by forming a lamellar structure with fatty acids and cholesterol, important functions such as barrier function to prevent irritation from the outside world and moisture transpiration from the skin, skin moisturizing function, etc. Plays an important role. It is also known to exist in hair as a component of the cell membrane complex and contribute to the adhesion between the cuticle and cortex. As described above, ceramide has been widely known as a useful component in skin or hair cosmetics, but has a high melting point, high crystallinity, and poor solubility in oils. Even if it can be blended, there is a problem in terms of stability such as precipitation over time. As a method for improving such a problem, a method of using in combination with various components has been disclosed, but it is still not sufficient (for example, Patent Documents 1 to 3).
一方、特許文献4にはセラミド類に含まれる水酸基をヒドロキシカルボン酸でエステル化したセラミド誘導体が開示され、保湿効果を有することが記載されているが、このセラミド誘導体の化粧料への配合のしやすさや処方中での安定性については記載されていない。また、特許文献5にはセラミド類に含まれる水酸基を脂肪酸でアシル化したセラミド誘導体が開示され、このセラミド誘導体が癌転移抑制等の効果を有し、脂肪乳剤への封入効率が向上することが記載されているが、具体的に開示された化合物はアセチル化体のみであり、且つ、このセラミド誘導体の化粧料用途における有効性については全く記載されていない。 On the other hand, Patent Document 4 discloses a ceramide derivative in which a hydroxyl group contained in ceramides is esterified with a hydroxycarboxylic acid and has a moisturizing effect. However, this ceramide derivative is incorporated into cosmetics. There is no mention of ease or stability during formulation. Patent Document 5 discloses a ceramide derivative obtained by acylating a hydroxyl group contained in ceramides with a fatty acid. This ceramide derivative has an effect of suppressing cancer metastasis and the like, and the encapsulation efficiency in a fat emulsion is improved. Although described, the specifically disclosed compounds are only acetylated compounds, and the effectiveness of the ceramide derivatives in cosmetics is not described at all.
化粧料への配合が容易であり、処方中での安定性に優れ、さらに皮膚や毛髪に対して優れた効果を発揮するセラミド誘導体を含有する化粧料を提供する。 Provided is a cosmetic containing a ceramide derivative that can be easily incorporated into cosmetics, has excellent stability during formulation, and exhibits excellent effects on skin and hair.
本発明者らは、上記課題を解決すべく鋭意検討を行った結果、セラミド類に含まれる水酸基の一部又は全てが炭素数4〜22の直鎖又は分岐鎖を有する脂肪酸でアシル化されたセラミド誘導体が、驚くべきことに、化粧料への配合が容易であり、処方中での安定性に優れ、さらに皮膚や毛髪に対して優れた効果を発揮することを見出し、本発明を完成させた。 As a result of intensive studies to solve the above-mentioned problems, the present inventors have acylated some or all of the hydroxyl groups contained in the ceramides with fatty acids having a linear or branched chain having 4 to 22 carbon atoms. Surprisingly, the ceramide derivative was found to be easily compounded into cosmetics, excellent in stability during formulation, and excellent in skin and hair, and the present invention was completed. It was.
本発明のセラミド誘導体は、融点が低く、油剤への溶解性に優れるため、化粧料に配合が容易であり、処方中での安定性にも優れる。また、本発明のセラミド誘導体は、皮膚の保湿性を向上させ、毛髪のダメージを回復するなど皮膚や毛髪に対して優れた効果を有する。 The ceramide derivative of the present invention has a low melting point and excellent solubility in an oil agent, so that it can be easily blended into cosmetics and has excellent stability during formulation. In addition, the ceramide derivative of the present invention has excellent effects on the skin and hair such as improving the moisture retention of the skin and recovering hair damage.
本発明に使用されるセラミド誘導体は、下記の一般式(1)で示されるセラミド類に含まれる水酸基の一部又は全てが、炭素数4〜22の直鎖又は分岐鎖を有する脂肪酸でアシル化された化合物である。
R1:1個以上の水酸基で置換されていてもよい炭素数7〜31の直鎖又は分岐鎖の飽和又は不飽和炭化水素基、若しくは、R4−COO−R3−(R3及びR4は水酸基で置換されていてもよい炭素数7〜31の直鎖又は分岐鎖の飽和又は不飽和炭化水素基を示す)
R2:1個以上の水酸基で置換されていてもよい炭素数7〜27の直鎖又は分岐鎖の飽和又は不飽和炭化水素基
A:下記一般式(2)から選ばれる基
R1: A linear or branched saturated or unsaturated hydrocarbon group having 7 to 31 carbon atoms which may be substituted with one or more hydroxyl groups, or R4-COO-R3- (R3 and R4 are substituted with hydroxyl groups) A C7-31 linear or branched saturated or unsaturated hydrocarbon group which may be
R2: a linear or branched saturated or unsaturated hydrocarbon group having 7 to 27 carbon atoms which may be substituted with one or more hydroxyl groups A: a group selected from the following general formula (2)
本発明のセラミド誘導体の合成に用いられるセラミド類としては、上記一般式(1)で表される化合物に包括されるものであれば特に制限はないが、より具体的には、スフィンゴシンの構造及び長鎖脂肪酸の構造の違いにより化5に示す化合物が天然に存在することが知られており、このような天然由来構造のセラミドを使用することが好ましい。このような天然由来構造のセラミドとしては、天然から抽出されたものを用いてもよいし、あるいは、発酵又は/及び合成により得られるものを用いてもよい。本発明のセラミド誘導体の合成には化5に示すようなセラミド類のいずれを用いてもよいが、これらのうち入手性等の観点からセラミド1、セラミド2、セラミド3、セラミド6が好ましく、さらにセラミド2、セラミド3が最も好ましい。セラミド2としては高砂香料工業よりセラミドTIC−001が、セラミド3としてはコスモファーム社よりCeramideIII、CeramideIIIA、CeramideIIIB、CeramideIIICが市販されており、このような市販品を用いてもよい。 The ceramide used for the synthesis of the ceramide derivative of the present invention is not particularly limited as long as it is encompassed by the compound represented by the general formula (1). More specifically, the structure of sphingosine and It is known that the compound shown in Chemical Formula 5 exists in nature due to the difference in the structure of the long chain fatty acid, and it is preferable to use a ceramide having such a naturally derived structure. As such naturally derived ceramides, those extracted from nature may be used, or those obtained by fermentation or / and synthesis may be used. Any of the ceramides shown in Chemical formula 5 may be used for the synthesis of the ceramide derivative of the present invention. Of these, ceramide 1, ceramide 2, ceramide 3, and ceramide 6 are preferred from the viewpoint of availability and the like. Ceramide 2 and ceramide 3 are most preferred. As ceramide 2, Ceramide TIC-001 is commercially available from Takasago International Corporation, and as Ceramide 3, Ceramide III, Ceramide IIIA, Ceramide IIIB, and Ceramide IIIC are commercially available from Cosmo Farm, and such commercially available products may be used.
本発明のセラミド誘導体の合成に用いられる炭素数4〜22の直鎖又は分岐鎖を有する脂肪酸としては、具体的には、酪酸、吉草酸、ヘキサン酸、ヘプタン酸、オクタン酸、ノナン酸、デカン酸、ウンデカン酸、ドデカン酸、トリデカン酸、テトラデカン酸、ペンタデカン酸、ヘキサデカン酸、ヘプタデカン酸、オクタデカン酸、ノナデカン酸、イコサン酸、ドコサン酸等の飽和直鎖脂肪酸;イソブタン酸、イソペンタン酸、ネオペンタン酸、イソヘキサン酸、イソヘプタン酸、2−エチルヘキサン酸、イソノナン酸、イソデカン酸、ジメチルオクタン酸、イソウンデカン酸、イソドデカン酸、2−ブチルオクタン酸、イソトリデカン酸、イソテトラデカン酸、イソペンタデカン酸、イソヘキサデカン酸、2−ヘキシルデカン酸、イソヘプタデカン酸、ダイマー酸の副産物から得られるイソステアリン酸、イソノナデカン酸、イソイコサン酸、2−オクチルドデカン酸、アンテイソヘンイコサン酸等の飽和分岐鎖脂肪酸;ウンデセン酸、ミリストオレイン酸、パルミトオレイン酸、オレイン酸、ダイマー酸の副産物から得られるイソオレイン酸、リノール酸、リノレン酸、エライジン酸、ガドレン酸、エイコサペンタエン酸、ドコサヘキサエン酸、エルカ酸、ブラシジン酸、アラキドン酸等の不飽和脂肪酸;オレンジ油脂肪酸、アボガド油脂肪酸、マカデミアナッツ油脂肪酸、オリーブ油脂肪酸、ホホバ油脂肪酸、ヤシ油脂肪酸、パーム核油脂肪酸、ヒマシ油脂肪酸、小麦胚芽油脂肪酸、サフラワー油脂肪酸、綿実油脂肪酸、ラノリン脂肪酸、ミンク油脂肪酸等の天然油脂由来脂肪酸等が挙げられる。これらの中でも、安定性の観点から飽和の直鎖又は分岐鎖脂肪酸が好ましく、また、得られる化合物の物性の面から炭素数は8〜18が好ましい。 Specific examples of the fatty acid having a linear or branched chain having 4 to 22 carbon atoms used for the synthesis of the ceramide derivative of the present invention include butyric acid, valeric acid, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decane. Saturated linear fatty acids such as acid, undecanoic acid, dodecanoic acid, tridecanoic acid, tetradecanoic acid, pentadecanoic acid, hexadecanoic acid, heptadecanoic acid, octadecanoic acid, nonadecanoic acid, icosanoic acid, docosanoic acid; isobutanoic acid, isopentanoic acid, neopentanoic acid, Isohexanoic acid, isoheptanoic acid, 2-ethylhexanoic acid, isononanoic acid, isodecanoic acid, dimethyloctanoic acid, isoundecanoic acid, isododecanoic acid, 2-butyloctanoic acid, isotridecanoic acid, isotetradecanoic acid, isopentadecanoic acid, isohexadecanoic acid, 2-hexyldecanoic acid, isohepta Saturated branched chain fatty acids such as isostearic acid, isononadodecanoic acid, isoicosanoic acid, 2-octyldodecanoic acid, and antiisohenicosanoic acid obtained from by-products of canic acid and dimer acid; undecenoic acid, myristoleic acid, palmitooleic acid Unsaturated fatty acids such as isooleic acid, linoleic acid, linolenic acid, elaidic acid, gadrenic acid, eicosapentaenoic acid, docosahexaenoic acid, erucic acid, brassic acid, arachidonic acid obtained from by-products of oleic acid and dimer acid; orange oil fatty acid , Avocado oil fatty acid, macadamia nut oil fatty acid, olive oil fatty acid, jojoba oil fatty acid, coconut oil fatty acid, palm kernel oil fatty acid, castor oil fatty acid, wheat germ oil fatty acid, safflower oil fatty acid, cottonseed oil fatty acid, lanolin fatty acid, mink oil fatty acid, etc. Fat derived from natural fats and oils Etc. The. Among these, a saturated linear or branched fatty acid is preferable from the viewpoint of stability, and the number of carbon atoms is preferably 8 to 18 from the viewpoint of physical properties of the obtained compound.
本発明に使用されるセラミド誘導体の製造方法は特に限定されず、公知の製法により製造することができる。具体的には、セラミド類と脂肪酸ハライドを塩基存在下、溶媒中で反応させることで目的の化合物を得ることができる。使用される塩基としては、ピリジン、4−ジメチルアミノピリジン、トリエチルアミン、エチルジイソプロピルアミン等が挙げられる。溶媒としてはアセトン、メチルエチルケトン、酢酸エチル、トルエン、ヘキサン、ベンゼン、ジクロロメタン、クロロホルム等が挙げられる。また、塩基を溶剤として用いて反応してもよい。反応温度は特に制限はないが、0〜100℃程度で行えばよく、反応速度や化合物の安定性等を考慮に入れると、より好ましくは40〜80℃程度で行うとよい。このようにして得られる本発明のセラミド誘導体はそのまま化粧料に使用してもよいが、抽出、脱酸、水洗、再結晶、吸着精製、蒸留、カラム精製等により適宜精製して使用してもよい。 The manufacturing method of the ceramide derivative used for this invention is not specifically limited, It can manufacture by a well-known manufacturing method. Specifically, the target compound can be obtained by reacting ceramides and a fatty acid halide in a solvent in the presence of a base. Examples of the base used include pyridine, 4-dimethylaminopyridine, triethylamine, ethyldiisopropylamine and the like. Examples of the solvent include acetone, methyl ethyl ketone, ethyl acetate, toluene, hexane, benzene, dichloromethane, chloroform and the like. Moreover, you may react using a base as a solvent. Although there is no restriction | limiting in particular in reaction temperature, what is necessary is just to carry out at about 0-100 degreeC, and considering reaction rate, stability of a compound, etc., it is more preferable to carry out at about 40-80 degreeC. The ceramide derivative of the present invention thus obtained may be used as it is in cosmetics, but may be used after being appropriately purified by extraction, deoxidation, washing with water, recrystallization, adsorption purification, distillation, column purification, etc. Good.
セラミド類と脂肪酸ハライドの反応比率は特に制限はないが、セラミド類1モル等量に対して脂肪酸ハライドを1〜5モル等量使用すると良く、セラミド類に含まれる水酸基の数に応じて適宜調整すると良い。より具体的には、セラミド類に含まれる水酸基1モル等量に対して脂肪酸を0.5〜1.5モル等量使用して反応させればよく、より好ましくは0.8〜1.2モル等量反応させるとよい。例えばセラミド2の場合は、セラミド2が1モル等量に対して脂肪酸ハライドを1〜3モル等量、より好ましくは1.6〜2.4モル等量反応させるとよい。セラミド3の場合は、セラミド3が1モル等量に対して脂肪酸ハライドを1.5〜4.5モル等量、より好ましくは2.4〜3.6モル等量反応させるとよい。 The reaction ratio of ceramides and fatty acid halides is not particularly limited, but 1 to 5 molar equivalents of fatty acid halides may be used with respect to 1 molar equivalent of ceramides, and adjusted as appropriate according to the number of hydroxyl groups contained in the ceramides. Good. More specifically, the reaction may be performed by using 0.5 to 1.5 mole equivalent of fatty acid with respect to 1 mole equivalent of hydroxyl group contained in ceramides, and more preferably 0.8 to 1.2. It is recommended to react at a molar equivalent. For example, in the case of ceramide 2, ceramide 2 may be reacted with 1 to 3 mole equivalents of fatty acid halide, more preferably 1.6 to 2.4 mole equivalents with respect to 1 mole equivalent. In the case of ceramide 3, ceramide 3 may be reacted with 1.5 to 4.5 mole equivalent, more preferably 2.4 to 3.6 mole equivalent of fatty acid halide with respect to 1 mole equivalent.
本発明のセラミド誘導体の化粧料への配合量は特に限定されないが、0.001〜50重量%が好ましく、より好ましくは0.005〜20重量%である。 Although the compounding quantity to the cosmetics of the ceramide derivative of this invention is not specifically limited, 0.001 to 50 weight% is preferable, More preferably, it is 0.005 to 20 weight%.
本発明のセラミド誘導体は、融点が低く、油剤への溶解性に優れるため、化粧料に配合が容易であり、処方中での安定性にも優れるものである。よって本発明のセラミド誘導体は水性媒体中に容易に安定分散させることが可能である。本発明における水性媒体とは、水を主成分とする液体媒体を意味し、水以外の成分として水溶性の無機又は有機物を含んでいてもよい。本発明のセラミド誘導体を水性媒体へ分散させる場合は、界面活性剤を使用して分散させるとよい。界面活性剤としては、後述する陰イオン性界面活性剤、非イオン界面活性剤、陽イオン性界面活性剤、両性界面活性剤、高分子界面活性剤等の一般的に使用される界面活性剤のいずれを用いてもよく、また、これらを2種以上混合して使用してもよい。これらの界面活性剤うち、より安定な化粧料が得られる点で、ジ長鎖アルキル第4級アンモニウム塩又はリン脂質を主に用いることが好ましい。また、さらにステロール類又は/及びポリオール類を併用すると安定性の面でより好ましい。 Since the ceramide derivative of the present invention has a low melting point and excellent solubility in an oil agent, it can be easily incorporated into cosmetics and has excellent stability during formulation. Therefore, the ceramide derivative of the present invention can be easily and stably dispersed in an aqueous medium. The aqueous medium in the present invention means a liquid medium mainly composed of water, and may contain a water-soluble inorganic or organic substance as a component other than water. When the ceramide derivative of the present invention is dispersed in an aqueous medium, it may be dispersed using a surfactant. As the surfactant, an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, a polymer surfactant and the like which are generally used are described later. Any of these may be used, or two or more of these may be mixed and used. Of these surfactants, it is preferable to mainly use di-long-chain alkyl quaternary ammonium salts or phospholipids in that a more stable cosmetic can be obtained. Further, it is more preferable in terms of stability to use sterols and / or polyols in combination.
本発明に用いるジ長鎖アルキル第4級アンモニム塩としては、長鎖アルキル部分の炭素数が8〜22であることが好ましく、具体的には、ジデシルジメチルアンモニウムクロリド、ジデシルジメチルアンモニウムブロミド、ジココイルジメチルアンモニウムクロリド、ジココイルジメチルアンモニウムブロミド、ジラウリルジメチルアンモニウムクロリド、ジセチルジメチルアンモニウムクロリド、ジセチルジメチルアンモニウムブロミド、ジステアリルジメチルアンモニウムクロリド、ジステアリルジメチルアンモニウムブロミド、ジオレイルジメチルアンモニウムクロリド、ジベヘニルジメチルアンモニウムクロリド、ジベヘニルジメチルアンモニウムブロミド、ジアルキルジメチルアンモニウムクロリド、ジアルキルジメチルアンモニウムブロミド、ジココイルエチルヒドロキシエチルモニウムメトサルフェート、ジパルミトイルエチルヒドロキシエチルモニウムメトサルフェート、ジステアロイルエチルヒドロキシエチルモニウムメトサルフェートなどが挙げられる。これらは2種以上を混合して用いてもよい。これらのうち、入手性や安定性等の観点から、ジココイルジメチルアンモニウムクロリド、ジステアリルジメチルアンモニウムクロリドが好ましいものとして挙げられる。化粧料への配合量は特に限定されないが、通常0.01〜20重量%、より好ましくは0.05〜10重量%である。 The di-long-chain alkyl quaternary ammonium salt used in the present invention preferably has 8 to 22 carbon atoms in the long-chain alkyl moiety, specifically, didecyldimethylammonium chloride, didecyldimethylammonium bromide, Dicocoyldimethylammonium chloride, dicocoyldimethylammonium bromide, dilauryldimethylammonium chloride, dicetyldimethylammonium chloride, dicetyldimethylammonium bromide, distearyldimethylammonium chloride, distearyldimethylammonium bromide, dioleyldimethylammonium chloride, dibehenyl Dimethylammonium chloride, dibehenyldimethylammonium bromide, dialkyldimethylammonium chloride, dialkyldimethylammonium Muburomido self coil hydroxyethylmonium methosulfate, dipalmitoyl hydroxyethylmonium methosulfate, etc. distearoylphosphatidylcholine hydroxyethylmonium methosulfate and the like. You may use these in mixture of 2 or more types. Among these, dicocoyl dimethyl ammonium chloride and distearyl dimethyl ammonium chloride are preferable from the viewpoint of availability and stability. Although the compounding quantity to cosmetics is not specifically limited, Usually, 0.01 to 20 weight%, More preferably, it is 0.05 to 10 weight%.
本発明に用いるリン脂質としては、大豆レシチン、卵黄レシチン等の天然レシチン、及び、これらの水素添加物又は/及びリゾ体;ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルイノシトール、ホスファチジルセリン、ホスファチジン酸等の極性基を有するジアシルグリセロリン脂質、及び、これらの水素添加物又は/及びリゾ体;スフィンゴエミリン、スフィンゴエタノールアミン等のスフィンゴリン脂質及びこれらの水素添加物等が挙げられる。さらにこれらはポリエチレングリコール等のポリオキシアルキレン基で修飾された誘導体であってもよい。これらのリン脂質は単独で用いてもよいし、2種以上を混合して用いてもよい。これらのうち、入手性や安定性等の観点から、大豆レシチン、卵黄レシチン及びこれらの水素添加物が好ましいものとして挙げられる。大豆レシチンや卵黄レシチンは、その精製度合いによりホスファチジルコリン純度の異なるものが市販されているが、いずれの純度のものを用いてもよい。化粧料への配合量は特に限定されないが、通常0.01〜10重量%、より好ましくは0.05〜5重量%である。 Examples of phospholipids used in the present invention include natural lecithins such as soybean lecithin and egg yolk lecithin, and hydrogenated products and / or lyso forms thereof; polar groups such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, and phosphatidic acid. And diacylglycerophospholipids, and hydrogenated products or / and lyso forms thereof; sphingophospholipids such as sphingoemilin and sphingoethanolamine, and hydrogenated products thereof. Furthermore, these may be derivatives modified with a polyoxyalkylene group such as polyethylene glycol. These phospholipids may be used alone or in combination of two or more. Among these, soybean lecithin, egg yolk lecithin, and hydrogenated products thereof are preferable from the viewpoints of availability, stability, and the like. As for soybean lecithin and egg yolk lecithin, those having different phosphatidylcholine purities depending on the degree of purification are commercially available, but those having any purity may be used. Although the compounding quantity to cosmetics is not specifically limited, Usually, 0.01 to 10 weight%, More preferably, it is 0.05 to 5 weight%.
本発明に用いるステロールとしては、コレステロール、ジヒドロコレステロール、ラノステロール、ジヒドロラノステロール、及びこれらの混合物である還元ラノリン、ラノリンアルコール;β−シトステロール、カンペステロール、スチグマステロール、ブラシカステロール、及びこれらの混合物であるフィトステロール等のステロール類が挙げられる。これらは2種以上を混合して用いてもよい。これらのうち、入手性や安定性等の観点から、コレステロール、フィトステロールが好ましいものとして挙げられる。化粧料への配合量は特に限定されないが、通常0.001〜5重量%、より好ましくは0.05〜3重量%である。 The sterols used in the present invention are cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, and reduced lanolin, lanolin alcohol, which are mixtures thereof; β-sitosterol, campesterol, stigmasterol, brassicasterol, and mixtures thereof. Examples include sterols such as phytosterols. You may use these in mixture of 2 or more types. Among these, cholesterol and phytosterol are preferable from the viewpoints of availability and stability. Although the compounding quantity to cosmetics is not specifically limited, Usually, 0.001 to 5 weight%, More preferably, it is 0.05 to 3 weight%.
本発明に用いるポリオールとしては、プロピレングリコール、1,3−プロパンジオール、ジプロピレングリコール、グリセリン、ジグリセリン、1、3−ブチレングリコール、1、2−ペンタンジオール、1、5−ペンタンジオール、イソプレングリコール、ソルビトール、ヘキシレングリコール、1、2−ヘキサンジオール、1、6−ヘキサンジオール、マルチトール、ポリエチレングリコールなどが挙げられる。これらは2種以上を混合して用いてもよい。これらのうち、入手性や安定性等の観点から、ヘキシレングリコール、プロピレングリコール、1,3−プロパンジオール、ジプロピレングリコール、1、3−ブチレングリコールが好ましいものとして挙げられる。化粧料への配合量は特に限定されないが、通常0.05〜50重量%、より好ましくは0.1〜20重量%である。 Examples of the polyol used in the present invention include propylene glycol, 1,3-propanediol, dipropylene glycol, glycerin, diglycerin, 1,3-butylene glycol, 1,2-pentanediol, 1,5-pentanediol, and isoprene glycol. Sorbitol, hexylene glycol, 1,2-hexanediol, 1,6-hexanediol, maltitol, polyethylene glycol and the like. You may use these in mixture of 2 or more types. Among these, hexylene glycol, propylene glycol, 1,3-propanediol, dipropylene glycol, and 1,3-butylene glycol are preferable from the viewpoints of availability and stability. Although the compounding quantity to cosmetics is not specifically limited, Usually, 0.05 to 50 weight%, More preferably, it is 0.1 to 20 weight%.
本発明のセラミド誘導体を含有する化粧料には、必要に応じて一般的に化粧料に配合される添加成分、例えば油性基剤、保湿剤、感触向上剤、界面活性剤、高分子、増粘・ゲル化剤、溶剤、噴射剤、酸化防止剤、還元剤、酸化剤、抗菌剤、防腐剤、キレート剤、pH調整剤、酸、アルカリ、粉体、無機塩、紫外線吸収剤、美白剤、ビタミン類及びその誘導体類、消炎剤、抗炎症剤、育毛用薬剤、血行促進剤、刺激剤、ホルモン類、抗しわ剤、抗老化剤、ひきしめ剤、冷感剤、温感剤、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤、植物・動物・微生物エキス、鎮痒剤、角質剥離・溶解剤、制汗剤、清涼剤、収れん剤、酵素、核酸、香料、色素、着色剤、染料、顔料、水等を配合することができる。 Cosmetics containing the ceramide derivative of the present invention include additives that are generally blended into cosmetics as necessary, for example, oily bases, moisturizers, feel improvers, surfactants, polymers, thickeners. Gelling agent, solvent, propellant, antioxidant, reducing agent, oxidizing agent, antibacterial agent, preservative, chelating agent, pH adjuster, acid, alkali, powder, inorganic salt, UV absorber, whitening agent, Vitamins and their derivatives, anti-inflammatory agents, anti-inflammatory agents, hair-growing agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensation agents, warm sensation agents, wound healing promotion Agent, stimulant relieving agent, analgesic agent, cell activator, plant / animal / microbe extract, antipruritic agent, exfoliating / dissolving agent, antiperspirant, refreshing agent, astringent, enzyme, nucleic acid, fragrance, pigment, colorant, Dyes, pigments, water and the like can be blended.
油性基剤としては、セタノール、ミリスチルアルコール、オレイルアルコール、ラウリルアルコール、セトステアリルアルコール、ステアリルアルコール、アラキルアルコール、ベヘニルアルコール、ホホバアルコール、キミルアルコール、セラキルアルコール、バチルアルコール、ヘキシルデカノール、イソステアリルアルコール、2−オクチルドデカノール、ダイマージオール等の高級アルコール類;ベンジルアルコール等のアラルキルアルコール及び誘導体;ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、イソステアリン酸、ベヘン酸、ウンデシレン酸、12−ヒドロキシステアリン酸、パルミトオレイン酸、オレイン酸、リノール酸、リノレイン酸、エルカ酸、ドコサヘキサエン酸、エイコサペンタエン酸、イソヘキサデカン酸、アンテイソヘンイコサン酸、長鎖分岐脂肪酸、ダイマー酸、水素添加ダイマー酸等の高級脂肪酸類及びそのアルミニウム塩、カルシウム塩、マグネシウム塩、亜鉛塩、カリウム、ナトリウム塩等の金属石けん類、及びアミド等の含窒素誘導体類;流動パラフィン(ミネラルオイル)、重質流動イソパラフィン、軽質流動イソパラフィン、α−オレフィンオリゴマー、ポリイソブテン、水添ポリイソブテン、ポリブテン、スクワラン、オリーブ由来スクワラン、スクワレン、ワセリン、固型パラフィン等の炭化水素類;キャンデリラワックス、カルナウバワックス、ライスワックス、木ろう、みつろう、モンタンワックス、オゾケライト、セレシン、パラフィンワックス、マイクロクリスタリンワックス、ペトロラタム、フィッシャートロプシュワックス、ポリエチレンワックス、エチレン・プロピレンコポリマー等のワックス類;ヤシ油、パーム油、パーム核油、サフラワー油、オリーブ油、ヒマシ油、アボカド油、ゴマ油、茶油、月見草油、小麦胚芽油、マカデミアナッツ油、ヘーゼルナッツ油、ククイナッツ油、ローズヒップ油、メドウフォーム油、パーシック油、ティートリー油、ハッカ油、トウモロコシ油、ナタネ油、ヒマワリ油、小麦胚芽油、アマニ油、綿実油、大豆油、落花生油、コメヌカ油、カカオ脂、シア脂、水素添加ヤシ油、水素添加ヒマシ油、ホホバ油、水素添加ホホバ油等の植物油脂類;牛脂、乳脂、馬脂、卵黄油、ミンク油、タートル油等の動物性油脂類;鯨ロウ、ラノリン、オレンジラッフィー油等の動物性ロウ類;液状ラノリン、還元ラノリン、吸着精製ラノリン、酢酸ラノリン、酢酸液状ラノリン、ヒドロキシラノリン、ポリオキシエチレンラノリン、ラノリン脂肪酸、硬質ラノリン脂肪酸、ラノリンアルコール、酢酸ラノリンアルコール、酢酸(セチル・ラノリル)エステル等のラノリン類;レシチン、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、ホスファチジルグリセロール、ホスファチジルイノシトール、スフィンゴミエリン等のスフィンゴリン脂質、ホスファチジン酸、リゾレシチン等のリン脂質類;水素添加大豆リン脂質、部分水素添加大豆リン脂質、水素添加卵黄リン脂質、部分水素添加卵黄リン脂質等のリン脂質誘導体類;コレステロール、ジヒドロコレステロール、ラノステロール、ジヒドロラノステロール、フィトステロール、コール酸等のステロール類;サポゲニン類;サポニン類;酢酸コレステリル、ノナン酸コレステリル、ステアリン酸コレステリル、イソステアリン酸コレステリル、オレイン酸コレステリル、N−ラウロイル−L−グルタミン酸ジ(コレステリル/ベヘニル/オクチルドデシル)、N−ラウロイル−L−グルタミン酸ジ(コレステリル/オクチルドデシル)、N−ラウロイル−L−グルタミン酸ジ(フィトステリル/ベヘニル/オクチルドデシル)、N−ラウロイル−L−グルタミン酸ジ(フィトステリル/オクチルドデシル)、N−ラウロイルサルコシンイソプロピル等のアシルサルコシンアルキルエステル、12−ヒドロキシステアリン酸コレステリル、マカデミアナッツ油脂肪酸コレステリル、マカデミアナッツ油脂肪酸フィトステリル、イソステアリン酸フィトステリル、軟質ラノリン脂肪酸コレステリル、硬質ラノリン脂肪酸コレステリル、長鎖分岐脂肪酸コレステリル、長鎖α−ヒドロキシ脂肪酸コレステリル等のステロールエステル類;リン脂質・コレステロール複合体、リン脂質・フィトステロール複合体等の脂質複合体;ミリスチン酸オクチルドデシル、ミリスチン酸ヘキシルデシル、イソステアリン酸オクチルドデシル、パリミチン酸セチル、パルミチン酸オクチルドデシル、オクタン酸セチル、オクタン酸ヘキシルデシル、イソノナン酸イソトリデシル、イソノナン酸イソノニル、イソノナン酸オクチル、イソノナン酸イソトリデシル、ネオペンタン酸イソデシル、ネオペンタン酸イソトリデシル、ネオペンタン酸イソステアリル、ネオデカン酸オクチルドデシル、オレイン酸オレイル、オレイン酸オクチルドデシル、リシノレイン酸オクチルドデシル、ラノリン脂肪酸オクチルドデシル、ジメチルオクタン酸ヘキシルデシル、エルカ酸オクチルドデシル、イソステアリン酸硬化ヒマシ油、オレイン酸エチル、アボカド油脂肪酸エチル、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、パルミチン酸オクチル、イソステアリン酸イソプロピル、ラノリン脂肪酸イソプロピル、セバシン酸ジエチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、アジピン酸ジイソプロピル、セバシン酸ジブチルオクチル、アジピン酸ジイソブチル、コハク酸ジオクチル、クエン酸トリエチル等のモノアルコールカルボン酸エステル類;乳酸セチル、リンゴ酸ジイソステアリル、モノイソステアリン酸水添ヒマシ油等のオキシ酸エステル類;トリオクタン酸グリセリル、トリオレイン酸グリセリル、トリイソステアリン酸グリセリル、ジイソステアリン酸グリセリル、トリ(カプリル酸/カプリン酸)グリセリル、トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリル、水添ロジントリグリセリド(水素添加エステルガム)、ロジントリグリセリド(エステルガム)、ベヘン酸エイコサン二酸グリセリル、トリオクタン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、ジオクタン酸ネオペンチルグリコール、ジカプリン酸ネオペンチルグリコール、ジオクタン酸2−ブチル−2−エチル−1,3−プロパンジオール、ジオレイン酸プロピレングリコール、テトラオクタン酸ペンタエリスリチル、水素添加ロジンペンタエリスリチル、トリエチルヘキサン酸ジトリメチロールプロパン、(イソステアリン酸/セバシン酸)ジトリメチロールプロパン、トリエチルヘキサン酸ペンタエリスリチル、(ヒドロキシステアリン酸/ステアリン酸/ロジン酸)ジペンタエリスリチル、ジイソステアリン酸ジグリセリル、テトライソステアリン酸ポリグリセリル、ノナイソステアリン酸ポリグリセリル−10、デカ(エルカ酸/イソステアリン酸/リシノレイン酸)ポリグリセリル−8、(ヘキシルデカン酸/セバシン酸)ジグリセリルオリゴエステル、ジステアリン酸グリコール(ジステアリン酸エチレングリコール)、ジネオペンタン酸3−メチル−1,5−ペンタンジオール、ジネオペンタン酸2,4−ジエチル−1,5−ペンタンジオール等の多価アルコール脂肪酸エステル類;ダイマージリノール酸ジイソプロピル、ダイマージリノール酸ジイソステアリル、ダイマージリノール酸ジ(イソステアリル/フィトステリル)、ダイマージリノール酸(フィトステリル/ベヘニル)、ダイマージリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)、ダイマージリノール酸ダイマージリノレイル、ジイソステアリン酸ダイマージリノレイル、ダイマージリノレイル水添ロジン縮合物、ダイマージリノール酸硬化ヒマシ油、ヒドロキシアルキルダイマージリノレイルエーテル等のダイマー酸若しくはダイマージオールの誘導体;ヤシ油脂肪酸モノエタノールアミド(コカミドMEA)、ヤシ油脂肪酸ジエタノールアミド(コカミドDEA)、ラウリン酸モノエタノールアミド(ラウラミドMEA)、ラウリン酸ジエタノールアミド(ラウラミドDEA)、ラウリン酸モノイソプロパノールアミド(ラウラミドMIPA)、パルミチン酸モノエタノールアミド(パルタミドMEA)、パルミチン酸ジエタノールアミド(パルタミドDEA)、ヤシ油脂肪酸メチルエタノールアミド(コカミドメチルMEA)等の脂肪酸アルカノールアミド類;ジメチコン(ジメチルポリシロキサン)、高重合ジメチコン(高重合ジメチルポリシロキサン)、シクロメチコン(環状ジメチルシロキサン、デカメチルシクロペンタシロキサン)、フェニルトリメチコン、ジフェニルジメチコン、フェニルジメチコン、ステアロキシプロピルジメチルアミン、(アミノエチルアミノプロピルメチコン/ジメチコン)コポリマー、ジメチコノール、ジメチコノールクロスポリマー、シリコーン樹脂、シリコーンゴム、アミノプロピルジメチコン及びアモジメチコン等のアミノ変性シリコーン、カチオン変性シリコーン、ジメチコンコポリオール等のポリエーテル変性シリコーン、ポリグリセリン変性シリコーン、糖変性シリコーン、カルボン酸変性シリコーン、リン酸変性シリコーン、硫酸変性シリコーン、アルキル変性シリコーン、脂肪酸変性シリコーン、アルキルエーテル変性シリコーン、アミノ酸変性シリコーン、ペプチド変性シリコーン、フッ素変性シリコーン、カチオン変性及びポリエーテル変性シリコーン、アミノ変性及びポリエーテル変性シリコーン、アルキル変性及びポリエーテル変性シリコーン、ポリシロキサン・オキシアルキレン共重合体等のシリコーン類;パーフルオロデカン、パーフルオロオクタン、パーフルオロポリエーテル等のフッ素系油剤類が、好ましいものとして挙げられる。 Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as cannic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Type hydrocarbons such as candelilla wax, carnauba wax, rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Tropsch wax, polyethylene wax, waxes such as ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cacao butter, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Fats and oils; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, Phospholipid derivatives such as partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytoster And sterols such as cholol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di (N-lauroyl-L-glutamate) ), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N Acyl sarcosine alkyl esters such as lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phyto Sterol esters such as steryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / phytosterol complex, etc. Lipid complex: octyldodecyl myristate, hexyl decyl myristate, octyl dodecyl isostearate, cetyl paritate, octyldodecyl palmitate, cetyl octanoate, hexyl decyl octanoate, isotridecyl isononanoate, isononyl isononanoate, isononanoate Isotridecyl acid, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octeodecanoate Ludodecyl, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, ethyl avocado oil, isopropyl myristate , Isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyl octyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate, etc. Monoalcohol carboxylic acid esters; cetyl lactate, diisostearyl malate, monoisostearyl Oxyacid esters such as acid hydrogenated castor oil; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic / capric), tri (caprylic / capric / myristin) Acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate , Neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrtetraoctanoate Chill, hydrogenated rosin pentaerythrityl, triethylhexanoic acid ditrimethylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, triethylhexanoic acid pentaerythrityl, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diisostearic acid di Glyceryl, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate) , Dineopentanoic acid 3-methyl-1,5-pentanediol, dineopentanoic acid 2,4-diethyl-1,5-pentane Polyhydric alcohol fatty acid esters such as ol; dimer dilinoleate diisopropyl, dimer dilinoleate diisostearyl, dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate (phytosteryl / behenyl), dimer dilinoleate (Phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearic dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl die Dimer acid or dimer diol derivative such as merlinoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), Lauri Acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil Fatty acid alkanolamides such as fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone , Diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) Polymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicone such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carvone Acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and poly-modified Ether-modified silicone, alkyl-modified and polyether-modified silicone, polysiloxane-oxyalkylene copolymer Silicones such as body; perfluorodecane, perfluorooctane, fluorine-based oils such as perfluoropolyether may be mentioned as preferred.
保湿剤・感触向上剤としては、グリセリン、1,3−ブチレングリコール、プロピレングリコール、3−メチル−1,3−ブタンジオール、1,3−プロパンジオール、2−メチル−1,3−プロパンジオール、トリメチロールプロパン、ペンタエリスリトール、ヘキシレングリコール、ジグリセリン、ポリグリセリン、ジエチレングリコール、ポリエチレングリコール、ジプロピレングリコール、ポリプロピレングリコール、エチレングリコール・プロピレングリコール共重合体等のポリオール類及びその重合体;ジエチレングリコールモノエチルエーテル(エトキシジグリコール)、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、ジエチレングリコールジブチルエーテル等のグリコールアルキルエーテル類;(エイコサン二酸/テトラデカン二酸)ポリグリセリル−10、テトラデカン二酸ポリグリセリル−10、シクロヘキサンジカルボン酸ビスエトキシジグリコール等の水溶性エステル類;ソルビトール、キシリトール、エリスリトール、マンニトール、マルチトール等の糖アルコール類;グルコース、フルクトース、ガラクトース、マンノース、トレオース、キシロース、アラビノース、フコース、リボース、デオキシリボース、マルトース、トレハロース、ラクトース、ラフィノース、グルコン酸、グルクロン酸、シクロデキストリン類(α−、β−、γ−シクロデキストリン、及び、マルトシル化、ヒドロキシアルキル化等の修飾シクロデキストリン)、β−グルカン、キチン、キトサン、ヘパリン及び誘導体、ペクチン、アラビノガラクタン、デキストリン、デキストラン、グリコーゲン、エチルグルコシド、メタクリル酸グルコシルエチル重合物若しくは共重合物等の糖類及びその誘導体類;ヒアルロン酸、ヒアルロン酸ナトリウム;コンドロイチン硫酸ナトリウム;ムコイチン硫酸、カロニン硫酸、ケラト硫酸、デルマタン硫酸;シロキクラゲ抽出物、シロキクラゲ多糖体;フコイダン;チューベロース多糖体、天然由来多糖体;クエン酸、酒石酸、乳酸等の有機酸及びその塩;尿素;2−ピロリドン−5−カルボン酸及びそのナトリウム等の塩;ベタイン(トリメチルグリシン)、プロリン、ヒドロキシプロリン、アルギニン、リジン、セリン、グリシン、アラニン、フェニルアラニン、チロシン、β−アラニン、スレオニン、グルタミン酸、グルタミン、アスパラギン、アスパラギン酸、システイン、シスチン、メチオニン、ロイシン、イソロイシン、バリン、トリプトファン、ヒスチジン、タウリン等のアミノ酸類及びその塩;コラーゲン、魚由来コラーゲン、アテロコラーゲン、ゼラチン、エラスチン、コラーゲン分解ペプチド、加水分解コラーゲン、塩化ヒドロキシプロピルアンモニウム加水分解コラーゲン、エラスチン分解ペプチド、ケラチン分解ペプチド、加水分解ケラチン、コンキオリン分解ペプチド、加水分解コンキオリン、シルク蛋白分解ペプチド、加水分解シルク、ラウロイル加水分解シルクナトリウム、大豆蛋白分解ペプチド、小麦蛋白分解ペプチド、加水分解小麦蛋白、カゼイン分解ペプチド、アシル化ペプチド等の蛋白ペプチド類及びその誘導体;パルミトイルオリゴペプチド、パルミトイルペンタペプチド、パルミトイルテトラペプチド等のアシル化ペプチド類;シリル化ペプチド類;乳酸菌培養液、酵母抽出液、卵殻膜タンパク、牛顎下腺ムチン、ヒポタウリン、ゴマリグナン配糖体、グルタチオン、アルブミン、乳清;塩化コリン、ホスホリルコリン;胎盤抽出液、エアラスチン、コラーゲン、アロエ抽出物、ハマメリス水、ヘチマ水、カモミラエキス、カンゾウエキス、コンフリーエキス、シルクエキス、イザヨイバラエキス、セイヨウノコギリソウエキス、ユーカリエキス、メリロートエキス等の動物・植物抽出成分、天然型セラミド(タイプ1、2、3、4、5、6、7)、ヒドロキシセラミド、疑似セラミド、スフィンゴ糖脂質、セラミド及び糖セラミド含有エキス等のセラミド類が好ましいものとして挙げられる。 As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosane diacid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan Sulfuric acid; white jellyfish extract; white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium Salt: betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, aspa Amino acids such as gin, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and the salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagenolytic peptide, hydrolyzed collagen, Hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat protein Degraded peptides, hydrolyzed wheat protein, casein-degraded peptides, acylated peptides and other protein peptides and their derivatives; palmitoyl oligopeptides , Acylated peptides such as palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, glutathione, albumin, milk Chin; choline chloride, phosphorylcholine; placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract, merirot extract Preferred are ceramides such as animal / plant extract components such as natural ceramide (types 1, 2, 3, 4, 5, 6, 7), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide, and sugar-ceramide-containing extract. Shall And the like.
界面活性剤としては、陰イオン性界面活性剤、非イオン界面活性剤、陽イオン性界面活性剤、両性界面活性剤、高分子界面活性剤等が好ましいものとして挙げられる。界面活性剤のHLBには特に制限はなく、1程度の低いものから20程度の高いものまで使用でき、HLB低いものと高いものを組み合わせることも好ましい。界面活性剤として好ましいものを例示すると、陰イオン性界面活性剤では、ラウリン酸カリウム、ミリスチン酸カリウム等の脂肪酸塩;ラウリル硫酸ナトリウム、ラウリル硫酸トリエタノールアミン、ラウリル硫酸アンモニウム等のアルキル硫酸エステル塩;ラウレス硫酸ナトリウム、ラウレス硫酸トリエタノールアミン等のポリオキシエチレンアルキル硫酸塩;ココイルメチルタウリンナトリウム、ココイルメチルタウリンカリウム、ラウロイルメチルタウリンナトリウム、ミリストイルメチルタウリンナトリウム、ラウロイルメチルアラニンナトリウム、ラウロイルサルコシンナトリウム、ラウロイルサルコシントリエタノールアミン、ラウロイルグルタミン酸メチルアラニンナトリウム等のアシルN−メチルアミノ酸塩;ココイルグルタミン酸ナトリウム、ココイルグルタミン酸トリエタノールアミン、ラウロイルグルタミン酸ナトリウム、ミリストイルグルタミン酸ナトリウム、ステアロイルグルタミン酸ナトリウム、パルミトイルアスパラギン酸ジトリエタノールアミン、ココイルアラニントリエタノールアミン等のアシルアミノ酸塩;ラウレス酢酸ナトリウム等のポリオキシエチレンアルキルエーテル酢酸塩;ラウロイルモノエタノールアミドコハク酸ナトリウム等のコハク酸エステル塩;脂肪酸アルカノールアミドエーテルカルボン酸塩;アシル乳酸塩;ポリオキシエチレン脂肪アミン硫酸塩;脂肪酸アルカノールアミド硫酸塩;硬化ヤシ油脂肪酸グリセリン硫酸ナトリウム等の脂肪酸グリセリド硫酸塩;アルキルベンゼンポリオキシエチレン硫酸塩;α−オレフィンスルホン酸ナトリウム等のオレフィンスルホン酸塩;スルホコハク酸ラウリル2ナトリウム、スルホコハク酸ジオクチルナトリウム等のアルキルスルホコハク酸塩;スルホコハク酸ラウレス2ナトリウム、モノラウロイルモノエタノールアミドポリオキシエチレンスルホコハク酸ナトリウム、ラウリルポリプロピレングリコールスルホコハク酸ナトリウム等のアルキルエーテルスルホコハク酸塩;テトラデシルベンゼンスルホン酸ナトリウム、テトラデシルベンゼンスルホン酸トリエタノールアミン等のアルキルベンゼンスルホン酸塩;アルキルナフタレンスルホン酸塩;アルカンスルホン酸塩;α−スルホ脂肪酸メチルエステル塩;アシルイセチオン酸塩;アルキルグリシジルエーテルスルホン酸塩;アルキルスルホ酢酸塩;ラウレスリン酸ナトリウム、ジラウレスリン酸ナトリウム、トリラウレスリン酸ナトリウム、モノオレスリン酸ナトリウム等のアルキルエーテルリン酸エステル塩;ラウリルリン酸カリウム等のアルキルリン酸エステル塩;カゼインナトリウム;アルキルアリールエーテルリン酸塩;脂肪酸アミドエーテルリン酸塩;ホスファチジルグリセロール、ホスファチジルイノシトール、ホスファチジン酸等のリン脂質類;カルボン酸変性シリコーン、リン酸変性シリコーン、硫酸変性シリコーン等のシリコーン系陰イオン性界面活性剤等;非イオン界面活性剤では、ラウレス(ポリオキシエチレンラウリルエーテル)類、セテス(ポリオキシエチレンセチルエーテル)類、ステアレス(ポリオキシエチレンステアリルエーテル)類、ベヘネス類(ポリオキシエチレンベヘニルエーテル)、イソステアレス(ポリオキシエチレンイソステアリルエーテル)類、オクチルドデセス(ポリオキシエチレンオクチルドデシルエーテル)類等の種々のポリオキシエチレン付加数のポリオキシエチレンアルキルエーテル類;ポリオキシエチレンアルキルフェニルエーテル;ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンヒマシ油、ポリオキシエチレン硬化ヒマシ油モノイソステアレート、ポリオキシエチレン硬化ヒマシ油トリイソステアレート、ポリオキシエチレン硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、ポリオキシエチレン硬化ヒマシ油マレイン酸等のヒマシ油及び硬化ヒマシ油誘導体;ポリオキシエチレンフィトステロール;ポリオキシエチレンコレステロール;ポリオキシエチレンコレスタノール;ポリオキシエチレンラノリン;ポリオキシエチレン還元ラノリン;ポリオキシエチレン・ポリオキシプロピレンセチルエーテル、ポリオキシエチレン・ポリオキシプロピレン2−デシルテトラデシルエーテル、ポリオキシエチレン・ポリオキシプロピレンモノブチルエーテル、ポリオキシエチレン・ポリオキシプロピレン水添ラノリン、ポリオキシエチレン・ポリオキシプロピレングリセリンエーテル等のポリオキシエチレン・ポリオキシプロピレンアルキルエーテル;ポリオキシエチレン・ポリオキシプロピレングリコール;PPG−9ジグリセリル等の(ポリ)グリセリンポリオキシプロピレングリコール;ステアリン酸グリセリル、イソステアリン酸グリセリル、パルミチン酸グリセリル、ミリスチン酸グリセリル、オレイン酸グリセリル、ヤシ油脂肪酸グリセリル、モノ綿実油脂肪酸グリセリン、モノエルカ酸グリセリン、セスキオレイン酸グリセリン、α,α’−オレイン酸ピログルタミン酸グリセリン、モノステアリン酸グリセリンリンゴ酸等のグリセリン脂肪酸部分エステル類;ステアリン酸ポリグリセリル−2、同3、同4、同5、同6、同8、同10、ジステアリン酸ポリグリセリル−6、同10、トリステアリン酸ポリグリセリル−2、デカステアリン酸ポリグリセリル−10、イソステアリン酸ポリグリセリル−2、同3、同4、同5、同6、同8、同10、ジイソステアリン酸ポリグリセリル−2(ジイソステアリン酸ジグリセリル)、同3、同10、トリイソステアリン酸ポリグリセリル−2、テトライソステアリン酸ポリグリセリル−2、デカイソステアリン酸ポリグリセリル−10、オレイン酸ポリグリセリル−2、同3、同4、同5、同6、同8、同10、ジオレイン酸ポリグリセリル−6、トリオレイン酸ポリグリセリル−2、デカオレイン酸ポリグリセリル−10等のポリグリセリン脂肪酸エステル;モノステアリン酸エチレングリコール等のエチレングリコールモノ脂肪酸エステル;モノステアリン酸プロピレングリコール等のプロピレングリコールモノ脂肪酸エステル;ペンタエリスリトール部分脂肪酸エステル;ソルビトール部分脂肪酸エステル;マルチトール部分脂肪酸エステル;マルチトールエーテル;ソルビタンモノオレエート、ソルビタンモノイソステアレート、ソルビタンモノラウレート、ソルビタンモノパルミテート、ソルビタンモノステアレート、ソルビタンセスキオレエート、ソルビタントリオレエート、ペンタ−2−エチルヘキシル酸ジグリセロールソルビタン、テトラ−2−エチルヘキシル酸ジグリセロールソルビタン等のソルビタン脂肪酸エステル;ショ糖脂肪酸エステル、メチルグルコシド脂肪酸エステル、ウンデシレン酸トレハロース等の糖誘導体部分エステル;カプリリルグルコシド等のアルキルグルコシド;アルキルポリグリコシド;ラノリンアルコール;還元ラノリン;ポリオキシエチレンジステアレート、ポリチレングリコールジイソステアレート、ポリオキシエチレンモノオレエート、ポリオキシエチレンジオレエート等のポリオキシエチレン脂肪酸モノ及びジエステル;ポリオキシエチレン・プロピレングリコール脂肪酸エステル;ポリオキシエチレングリセリンモノステアレート、ポリオキシエチレングリセリンモノイソステアレート、ポリオキシエチレングリセリントリイソステアレート等のポリオキシエチレンモノオレエート等のポリオキシエチレングリセリン脂肪酸エステル;ポリオキシエチレンソルビタンモノオレエート、ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレンソルビタンモノオレート、ポリオキシエチレンソルビタンテトラオレエート等のポリオキシエチレンソルビタン脂肪酸エステル;ポリオキシエチレンソルビトールモノラウレート、ポリオキシエチレンソルビトールモノオレエート、ポリオキシエチレンソルビトールペンタオレエート、ポリオキシエチレンソルビトールモノステアレート等のポリオキシエチレンソルビトール脂肪酸エステル;ポリオキシエチレンメチルグルコシド脂肪酸エステル;ポリオキシエチレンアルキルエーテル脂肪酸エステル;ポリオキシエチレンソルビトールミツロウ等のポリオキシエチレン動植物油脂類;イソステアリルグリセリルエーテル、キミルアルコール、セラキルアルコール、バチルアルコール等のアルキルグリセリルエーテル類;多価アルコールアルキルエーテル;ポリオキシエチレンアルキルアミン;テトラポリオキシエチレン・テトラポリオキシプロピレン−エチレンジアミン縮合物類;サポニン、ソホロリピッド等の天然系界面活性剤;ポリオキシエチレン脂肪酸アミド;ヤシ油脂肪酸モノエタノールアミド(コカミドMEA)、ヤシ油脂肪酸ジエタノールアミド(コカミドDEA)、ラウリン酸モノエタノールアミド(ラウラミドMEA)、ラウリン酸ジエタノールアミド(ラウラミドDEA)、ラウリン酸モノイソプロパノールアミド(ラウラミドMIPA)、パルミチン酸モノエタノールアミド(パルタミドMEA)、パルミチン酸ジエタノールアミド(パルタミドDEA)、ヤシ油脂肪酸メチルエタノールアミド(コカミドメチルMEA)等の脂肪酸アルカノールアミド類;ラウラミンオキシド、コカミンオキシド、ステアラミンオキシド、ベヘナミンオキシド等のアルキルジメチルアミンオキシド;アルキルエトキシジメチルアミンオキシド;ポリオキシエチレンアルキルメルカプタン;ジメチコンコポリオール等のポリエーテル変性シリコーン、ポリシロキサン・オキシアルキレン共重合体、ポリグリセリン変性シリコーン、糖変性シリコーン等のシリコーン系非イオン性界面活性剤等;陽イオン性界面活性剤では、ベヘントリモニウムクロリド、ステアルトリモニウムクロリド、セトリモニウムクロリド、ラウリルトリモニウムクロリド等のアルキルトリメチルアンモニウムクロリド;ステアリルトリモニウムブロミド等のアルキルトリメチルアンモニウムブロミド;ジステアリルジモニウムクロリド、ジココジモニウムクロリド等のジアルキルジメチルアンモニウムクロリド;ステアラミドプロピルジメチルアミン、ステアラミドエチルジエチルアミン等の脂肪酸アミドアミン及びその塩;ステアロキシプロピルジメチルアミン等のアルキルエーテルアミン及びその塩または四級塩;エチル硫酸長鎖分岐脂肪酸(12〜31)アミノプロピルエチルジメチルアンモニウム、エチル硫酸ラノリン脂肪酸アミノプロピルエチルジメチルアンモニウム等の脂肪酸アミド型四級アンモニウム塩;ポリオキシエチレンアルキルアミン及びその塩または四級塩;アルキルアミン塩;脂肪酸アミドグアニジウム塩;アルキルエーテルアミンモニウム塩;アルキルトリアルキレングリコールアンモニウム塩;ベンザルコニウム塩;ベンゼトニウム塩;塩化セチルピリジニウム等のピリジニウム塩;イミダゾリニウム塩;アルキルイソキノリニウム塩;ジアルキルモリホニウム塩;ポリアミン脂肪酸誘導体;アミノプロピルジメチコン及びアモジメチコン等のアミノ変性シリコーン、カチオン変性シリコーン、カチオン変性及びポリエーテル変性シリコーン、アミノ変性及びポリエーテル変性シリコーン等のシリコーン系陽イオン性界面活性剤等;
両性界面活性剤では、ラウリルベタイン(ラウリルジメチルアミノ酢酸ベタイン)等のN−アルキル−N,N−ジメチルアミノ酸ベタイン;コカミドプロピルベタイン、ラウラミドプロピルベタイン等の脂肪酸アミドアルキル−N,N−ジメチルアミノ酸ベタイン;ココアンホ酢酸ナトリウム、ラウロアンホ酢酸ナトリウム等のイミダゾリン型ベタイン;アルキルジメチルタウリン等のアルキルスルホベタイン;アルキルジメチルアミノエタノール硫酸エステル等の硫酸型ベタイン;アルキルジメチルアミノエタノールリン酸エステル等のリン酸型ベタイン;ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、スフィンゴミエリン等のスフィンゴリン脂質、リゾレシチン、水素添加大豆リン脂質、部分水素添加大豆リン脂質、水素添加卵黄リン脂質、部分水素添加卵黄リン脂質、水酸化レシチン等のリン脂質類;シリコーン系両性界面活性剤等;高分子界面活性剤では、ポリビニルアルコール、アルギン酸ナトリウム、デンプン誘導体、トラガントガム、アクリル酸・メタアクリル酸アルキル共重合体;シリコーン系各種界面活性剤が好ましいものとして挙げられる。
Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium minate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonate; alkylsulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and tetraethanolamine tetraethanol; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laurethrin Alkyl ether phosphates such as sodium, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide ether phosphorus Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants, laureth (Polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez (polyoxyethylene) Nbehenyl ethers), isosteares (polyoxyethylene isostearyl ethers), octyldecesses (polyoxyethylene octyldodecyl ethers) and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, poly Castor oil such as oxyethylene hydrogenated castor oil maleic acid and hydrogenated castor oil derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxy Polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene polyoxypropylene monobutyl ether, polyoxyethylene lanolin; Oxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, myristate group Glyceryl fatty acid partial esters such as ceryl, glyceryl oleate, glyceryl coconut fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, α, α'-oleic acid pyroglutamic acid glycerin, monostearic acid glycerin malic acid; Polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, polyglyceryl isostearate -2, 3, 4, 5, 6, 8, 10, diglycostyl diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl tetraisostearate Ril-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3,4, 5,6, 8,8, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol moieties Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monos Sorbitan fatty acid esters such as allate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside fatty acid ester, trehalose undecylenate, etc. Partial derivatives of sugar derivatives; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohols; reduced lanolin; polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene di- Polyoxyethylene fatty acid mono- and diesters such as oleate; polyoxyethylene propylene glycol fatty acid ester; polyoxyethylene Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as polyglycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxy Polyoxyethylene sorbitan fatty acid esters such as ethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol penta Polyoxyethylene sorbitol fatty acid esters such as oleate and polyoxyethylene sorbitol monostearate Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; Alkyl such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, batyl alcohol Glyceryl ethers; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil Fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (laura) De-MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl) Fatty acid alkanolamides such as MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; poly such as dimethicone copolyol Silicone such as ether-modified silicone, polysiloxane-oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone Nonionic surfactants, etc .; for cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; alkyls such as stearyltrimonium bromide Trialkylammonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ether amines such as stearoxypropyldimethylamine; Salt or quaternary salt thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl lanolin sulfate Fatty acid amide-type quaternary ammonium salts such as aminopropylethyldimethylammonium fatty acid; polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzalkonium salt; Pyridinium salt such as cetylpyridinium chloride; Imidazolinium salt; Alkylisoquinolinium salt; Dialkyl morpholinium salt; Polyamine fatty acid derivatives; Aminopropyl dimethicone and amodimethicone Silicone-based cationic surfactants such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone;
In amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N, N-dimethylamino acids such as cocamidopropyl betaine and lauramidopropyl betaine Betaines; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; Sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated Phospholipids such as soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants; polymer surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, Preferred are tragacanth gum, acrylic acid / alkyl methacrylate copolymer; and various silicone surfactants.
高分子・増粘剤・ゲル化剤としては、グアーガム、ローカストビーンガム、クィーンスシード、カラギーナン、ガラクタン、アラビアガム、タラガム、タマリンド、ファーセレラン、カラヤガム、トロロアオイ、キャラガム、トラガントガム、ペクチン、ペクチン酸及びナトリウム塩等の塩、アルギン酸及びナトリウム塩等の塩、マンナン;コメ、トウモロコシ、バレイショ、コムギ等のデンプン;キサンタンガム、デキストラン、サクシノグルカン、カードラン、ヒアルロン酸及びその塩、ザンサンガム、プルラン、ジェランガム、キチン、キトサン、寒天、カッソウエキス、コンドロイチン硫酸塩、カゼイン、コラーゲン、ゼラチン、アルブミン;メチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロース及びそのナトリウム等の塩、メチルヒドロキシプロピルセルロース、セルロース硫酸ナトリウム、ジアルキルジメチルアンモニウム硫酸セルロース、結晶セルロース、セルロース末等のセルロース及びその誘導体;可溶性デンプン、カルボキシメチルデンプン、メチルヒドロキシプロピルデンプン、メチルデンプン等のデンプン系高分子、塩化ヒドロキシプロピルトリモニウムデンプン、オクテニルコハク酸トウモロコシデンプンアルミニウム等のデンプン誘導体;アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等アルギン酸誘導体;ポリビニルピドリドン(PVP)、ポリビニルアルコール(PVA)、ビニルピドリドン・ビニルアルコール共重合体、ポリビニルメチルエーテル;ポリエチレングリコール、ポリプロピレングリコール、ポリオキシエチレン・ポリオキシプロピレン共重合体;(メタクリロイルオキシエチルカルボキシベタイン/メタクリル酸アルキル)コポリマー、(アクリレーツ/アクリル酸ステアリル/メタクリル酸エチルアミンオキシド)コポリマー等の両性メタクリル酸エステル共重合体;(ジメチコン/ビニルジメチコン)クロスポリマー、(アクリル酸アルキル/ジアセトンアクリルアミド)コポリマー、(アクリル酸アルキル/ジアセトンアクリルアミド)コポリマーAMP;ポリ酢酸ビニル部分けん化物、マレイン酸共重合体;ビニルピロリドン・メタクリル酸ジアルキルアミノアルキル共重合体;アクリル樹脂アルカノールアミン;ポリエステル、水分散性ポリエステル;ポリアクリルアミド;ポリアクリル酸エチル等のポリアクリル酸エステル共重合体、カルボキシビニルポリマー、ポリアクリル酸及びそのナトリウム塩等の塩、アクリル酸・メタアクリル酸エステル共重合体;アクリル酸・メタアクリル酸アルキル共重合体;ポリクオタニウム−10等のカチオン化セルロース、ポリクオタニウム−7等のジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、ポリクオタニウム−22等のアクリル酸・ジアリルジメチルアンモニウムクロリド共重合体、ポリクオタニウム−39等のアクリル酸・ジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、アクリル酸・カチオン化メタアクリル酸エステル共重合体、アクリル酸・カチオン化メタアクリル酸アミド共重合体、ポリクオタニウム−47等のアクリル酸・アクリル酸メチル・塩化メタクリルアミドプロピルトリメチルアンモニウム共重合体、塩化メタクリル酸コリンエステル重合体;カチオン化オリゴ糖、カチオン化デキストラン、グアーヒドロキシプロピルトリモニウムクロリド等のカチオン化多糖類;ポリエチレンイミン;カチオンポリマー;ポリクオタニウム−51等の2−メタクリロイルオキシエチルホスホリルコリンの重合体及びメタクリル酸ブチル共重合体等との共重合体;アクリル樹脂エマルジョン、ポリアクリル酸エチルエマルジョン、ポリアクリルアルキルエステルエマルジョン、ポリ酢酸ビニル樹脂エマルジョン、天然ゴムラテックス、合成ラテックス等の高分子エマルジョン;ニトロセルロース;ポリウレタン類及び各種共重合体;各種シリコーン類;アクリル−シリコーングラフト共重合体等のシリコーン系各種共重合体;各種フッ素系高分子;12−ヒドロキシステアリン酸及びその塩;パルミチン酸デキストリン、ミリスチン酸デキストリン等のデキストリン脂肪酸エステル;無水ケイ酸、煙霧状シリカ(超微粒子無水ケイ酸)、ケイ酸アルミニウムマグネシウム、ケイ酸ナトリウムマグネシウム、金属石鹸、ジアルキルリン酸金属塩、ベントナイト、ヘクトライト、有機変性粘土鉱物、ショ糖脂肪酸エステル、フラクトオリゴ糖脂肪酸エステルが好ましいものとして挙げられる。 Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.
溶剤・噴射剤類としては、エタノール、2−プロパノール(イソプロピルアルコール)、ブタノール、イソブチルアルコール等の低級アルコール類;プロピレングリコール、1,3−ブチレングリコール、ジエチレングリコール、ジプロピレングリコール、イソペンチルジオール等のグリコール類;ジエチレングリコールモノエチルエーテル(エトキシジグリコール)、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、トリエチレングリコールモノエチルエーテル、ジエチレングリコールジエチルエーテル、ジエチレングリコールジブチルエーテル、プロピレングリコールモノエチルエーテル、ジプロピレングリコールモノエチルエーテル等のグリコールエーテル類;エチレングリコールモノエチルエーテルアセテート、ジエチレングリコールモノエチルエーテルアセテート、プロピレングリコールモノエチルエーテルアセテート等のグリコールエーテルエステル類;コハク酸ジエトキシエチル、エチレングリコールジサクシネート等のグリコールエステル類;ベンジルアルコール、ベンジルオキシエタノール、炭酸プロピレン、炭酸ジアルキル、アセトン、酢酸エチル、N−メチルピロリドン;トルエン;フルオロカーボン、次世代フロン;LPG、ジメチルエーテル、炭酸ガス等の噴射剤が好ましいものとして挙げられる。 Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.
酸化防止剤としては、トコフェロール(ビタミンE)、酢酸トコフェロール等のトコフェロール誘導体;BHT、BHA;没食子酸プロピル等の没食子酸誘導体;ビタミンC(アスコルビン酸)および/またはその誘導体;エリソルビン酸及びその誘導体;亜硫酸ナトリウム等の亜硫酸塩;亜硫酸水素ナトリウム等の亜硫酸水素塩;チオ硫酸ナトリウム等のチオ硫酸塩;メタ亜硫酸水素塩;チオタウリン、ヒポタウリン;チオグリセロール、チオ尿素、チオグリコール酸、システイン塩酸塩が好ましいものとして挙げられる。還元剤としては、チオグリコール酸、システイン、システアミン等が好ましいものとして挙げられる。酸化剤としては、過酸化水素水、過硫酸アンモニウム、臭素酸ナトリウム、過炭酸等が好ましいものとして挙げられる。 Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.
抗菌剤又は防腐剤としては、メチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベン等のパラベン(ヒドロキシ安息香酸エステル)類;フェノキシエタノール;1,2−ペンタンジオール、1,2−ヘキサンジオール、1,2−オクタンジオール等の1,2−アルカンジオール類;2−エチルヘキシルグリセリルエーテル(エチルヘキシルグリセリン)等のアルキルグリセリルエーテル類;サリチル酸;安息香酸ナトリウム;メチルクロロイソチアゾリノン、メチルイソチアゾリノン等のイソチアゾリンオン誘導体;イミダゾリニウムウレア;デヒドロ酢酸及びその塩;フェノール類;トリクロサン等のハロゲン化ビスフェノール類、酸アミド類、四級アンモニウム塩類;トリクロロカルバニド、ジンクピリチオン、塩化ベンザルコニウム、塩化ベンゼトニウム、ソルビン酸、クロルヘキシジン、グルコン酸クロルヘキシジン、ハロカルバン、ヘキサクロロフェン、ヒノキチオール;フェノール、イソプロピルフェノール、クレゾール、チモール、パラクロロフェノール、フェニルフェノール、フェニルフェノールナトリウム等のその他フェノール類;フェニルエチルアルコール、感光素類、抗菌性ゼオライト、銀イオンが好ましいものとして挙げられるが、防腐を目的とした抗菌剤又は防腐剤として用いる場合は、化粧料又は皮膚外用剤の安全性の観点から、フェノキシエタノール;1,2−ペンタンジオール、1,2−ヘキサンジオール、1,2−オクタンジオール等の1,2−アルカンジオール類;2−エチルヘキシルグリセリルエーテル等のアルキルグリセリルエーテル類を用いることが、より好ましい。 Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazoline derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzoyl chloride Luconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol , Photosensitizers, antibacterial zeolite, and silver ion are preferable, but when used as an antibacterial agent or antiseptic agent for antiseptic purposes, phenoxyethanol; 1 from the viewpoint of safety of cosmetics or skin external preparations; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.
キレート剤としては、EDTA、EDTA2Na、EDTA3Na、EDTA4Na等のエデト酸塩(エチレンジアミン四酢酸塩);HEDTA3Na等のヒドロキシエチルエチレンジアミン三酢酸塩;ペンテト酸塩(ジエチレントリアミン五酢酸塩);フィチン酸;エチドロン酸等のホスホン酸及びそのナトリウム塩等の塩類;シュウ酸ナトリウム;ポリアスパラギン酸、ポリグルタミン酸等のポリポリアミノ酸類;ポリリン酸ナトリウム、メタリン酸ナトリウム、リン酸;クエン酸ナトリウム、クエン酸、アラニン、ジヒドロキシエチルグリシン、グルコン酸、アスコルビン酸、コハク酸、酒石酸が好ましいものとして挙げられる。pH調整剤・酸・アルカリとしては、クエン酸、クエン酸ナトリウム、乳酸、乳酸ナトリウム、グリコール酸、コハク酸、酢酸、酢酸ナトリウム、リンゴ酸、酒石酸、フマル酸、リン酸、塩酸、硫酸、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、イソプロパノールアミン、トリイソプロパノールアミン、2−アミノ−2−メチル−1,3ープロパンジオール、2−アミノ−2−ヒドロキシメチル−1,3ープロパンジオール、アルギニン、水酸化ナトリウム、水酸化カリウム、アンモニア水、炭酸グアニジン、炭酸アンモニウムが好ましいものとして挙げられる。 Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.
粉体類としては、マイカ、タルク、カオリン、セリサイト、モンモリロナイト、カオリナイト、雲母、白雲母、金雲母、合成雲母、紅雲母、黒雲母、パーミキュライト、炭酸マグネシウム、炭酸カルシウム、ケイ酸アルミニウム、ケイ酸バリウム、ケイ酸カルシウム、ケイ酸マグネシウム、ケイ酸ストロンチウム、タングステン酸金属塩、マグネシウム、ゼオライト、硫酸バリウム、焼成硫酸カルシウム、リン酸カルシウム、弗素アパタイト、ヒドロキシアパタイト、セラミックパウダー、ベントナイト、スメクタイト、粘土、泥、金属石鹸(例えば、ミリスチン酸亜鉛、パルミチン酸カルシウム、ステアリン酸アルミニウム)、炭酸カルシウム、ベンガラ、黄酸化鉄、黒酸化鉄、群青、紺青、カーボンブラック、酸化チタン、微粒子及び超微粒子酸化チタン、酸化亜鉛、微粒子及び超微粒子酸化亜鉛、アルミナ、シリカ、煙霧状シリカ(超微粒子無水ケイ酸)、雲母チタン、魚鱗箔、窒化ホウ素、ホトクロミック顔料、合成フッ素金雲母、微粒子複合粉体、金、アルミニウム等の各種の大きさ・形状の無機粉体、及び、これらをハイドロジェンシリコーン、環状ハイドロジェンシリコーン等のシリコーン若しくはその他のシラン若しくはチタンカップリング剤等の各種表面処理剤で処理を行って疎水化若しくは親水化した粉体等の無機粉体;デンプン、セルロース、ナイロンパウダー、ポリエチレン末、ポリメタクリル酸メチル末、ポリスチレン末、スチレンとアクリル酸の共重合体樹脂粉末、ポリエステル末、ベンゾグアナミン樹脂粉末、ポリエチレンテレフタレート・ポリメチルメタクリレート積層末、ポリエチレンテレフタレート・アルミニウム・エポキシ積層末等、ウレタン粉末、シリコーン粉末、テフロン(登録商標)粉末等の各種の大きさ・形状の有機系粉体及び表面処理粉体、有機無機複合粉体が好ましいものとして挙げられる。無機塩類としては、食塩、並塩、岩塩、海塩、天然塩等の塩化ナトリウム含有塩類;塩化カリウム、塩化アルミニウム、塩化カルシウム、塩化マグネシウム、にがり、塩化亜鉛、塩化アンモニウム;硫酸ナトリウム、硫酸アルミニウム、硫酸アルミニウム・カリウム(ミョウバン)、硫酸アルミニウム・アンモニウム、硫酸バリウム、硫酸カルシウム、硫酸カリウム、硫酸マグネシウム、硫酸亜鉛、硫酸鉄、硫酸銅;リン酸1Na・2Na・3Na等のリン酸ナトリウム類、リン酸カリウム類、リン酸カルシウム類、リン酸マグネシウム類が好ましいものとして挙げられる。 Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.
紫外線吸収剤としては、パラアミノ安息香酸、パラアミノ安息香酸モノグリセリンエステル、N,N−ジプロポキシパラアミノ安息香酸エチルエステル、N,N−ジエトキシパラアミノ安息香酸エチルエステル、N,N−ジメチルパラアミノ安息香酸エチルエステル、N,N−ジメチルパラアミノ安息香酸ブチルエステル、N,N−ジメチルパラアミノ安息香酸エチルエステル等の安息香酸系紫外線吸収剤;ホモメンチル−N−アセチルアントラニレート等のアントラニル酸系紫外線吸収剤;サリチル酸及びそのナトリウム塩、アミルサリシレート、メンチルサリシレート、ホモメンチルサリシレート、オクチルサリシレート、フェニルサリシレート、ベンジルサリシレート、p−イソプロパノールフェニルサリシレート等のサリチル酸系紫外線吸収剤;オクチルシンナメート、エチル−4−イソプロピルシンナメート、メチル−2,5−ジイソプロピルシンナメート、エチル−2,4−ジイソプロピルシンナメート、メチル−2,4−ジイソプロピルシンナメート、プロピル−p−メトキシシンナメート、イソプロピル−p−メトキシシンナメート、イソアミル−p−メトキシシンナメート、2−エチルヘキシルp−メトキシシンナメート(パラメトキシケイヒ酸オクチル)、2−エトキシエチル−p−メトキシシンナメート(シノキサート)、シクロヘキシル-p-メトキシシンナメート、エチル−α−シアノ−β−フェニルシンナメート、2−エチルヘキシルα−シアノ−β−フェニルシンナメート(オクトクリン)、グリセリルモノ−2−エチルヘキサノイル−ジパラメトキシシンナメート、フェルラ酸及びその誘導体等の桂皮酸系紫外線吸収剤;2,4−ジヒドロキシベンゾフェノン、2,2’−
ジヒドロキシ−4−メトキシベンゾフェノン、2,2’−ジヒドロキシ−4,4’−ジメトキシベンゾフェノン、2,2’,4,4’−テトラヒドロキシベンゾフェノン、2−ヒドロキシ−4−
メトキシベンゾフェノン(オキシベンゾン−3)、2−ヒドロキシ−4−メトキシ−4’−メチルベンゾフェノン、2−ヒドロキシ−4−メトキシベンゾフェノン−5−スルホン酸塩、4−フェニルベンゾフェノン、2−エチルヘキシル−4’−フェニル−ベンゾフェノン−2−カルボキシレート、2−ヒドロキシ−4−n−オクトキシベンゾフェノン、4−ヒドロキシ−3−カルボキシベンゾフェノン等のベンゾフェノン系紫外線吸収剤;3−(4’−メチルベンジリデン)−d,l−カンファー、3−ベンジリデン−d,l−カンファー;2−フェニル−5−メチルベンゾキサゾール;2,2’−ヒドロキシ−5−メチルフェニルベンゾトリアゾール;2−(2’−ヒドロキシ−5’−t−オクチルフェニル)ベンゾトリアゾール;2−(2’−ヒドロキシ−5’−メチルフェニルベンゾトリアゾール;ジベンザラジン;ジアニソイルメタン;5−(3,3−ジメチル−2−ノルボルニリデン)−3−ペンタン−2−オン;4−t−ブチルメトキシジベンゾイルメタン等のジベンゾイルメタン誘導体;オクチルトリアゾン;ウロカニン酸及びウロカニン酸エチル等のウロカニン酸誘導体;2−(2'−ヒドロキシ−5'−メチルフェニル)ベンゾトリアゾール、1−(3,4−ジメトキシフェニル)−4,4−ジメチル−1,3−ペンタンジオン、ジメトキシベンジリデンジオキソイミダゾリジンプロピオン酸2−エチルヘキシル等のヒダントイン誘導体、フェニルベンズイミダソゾールスルホン酸、テレフタリリデンジカンフルスルホン酸、ドロメトリゾールトリシロキサン、アントラニル酸メチル、ルチン及びその誘導体、オリザノール及びその誘導体が好ましいものとして挙げられる。
Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Nameto, cinnamic acid UV absorbers such as ferulic acid and its derivatives; 2,4-dihydroxybenzophenone, 2,2'-
Dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-
Methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl -Benzophenone ultraviolet absorbers such as benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3- (4'-methylbenzylidene) -d, l- Camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t- Octylphenyl) benzotriazole; 2- (2′-H Dioxy-5'-methylphenylbenzotriazole;dibenzalazine;dianisoylmethane; 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one; di- such as 4-t-butylmethoxydibenzoylmethane Benzoylmethane derivatives; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4, Hydantoin derivatives such as 4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, phenylbenzimidazolazole sulfonic acid, terephthalylidene dicamphulsulfonic acid, drometrizol trisiloxane, anthranyl Methyl, rutin and its derivatives, oryzanol and derivatives thereof as preferred.
美白剤としては、アルブチン、α−アルブチン等のヒドロキノン配糖体及びそのエステル類;アスコルビン酸、アスコルビン酸リン酸エステルナトリウム塩及びアスコルビン酸リン酸エステルマグネシウム塩等のアスコルビン酸リン酸エステル塩、アスコルビン酸テトライソパルミチン酸エステル等のアスコルビン酸脂肪酸エステル、アスコルビン酸エチルエーテル等のアスコルビン酸アルキルエーテル、アスコルビン酸−2−グルコシド等のアスコルビン酸グルコシドおよびその脂肪酸エステル類、アスコルビン酸硫酸エステル、リン酸トコフェリルアスコルビル等のアスコルビン酸誘導体;コウジ酸、エラグ酸、トラネキサム酸及びその誘導体、フェルラ酸及びその誘導体、プラセンタエキス、グルタチオン、オリザノール、ブチルレゾルシノール、油溶性カモミラエキス、油溶性カンゾウエキス、西河柳エキス、ユキノシタエキス等植物エキスが好ましいものとして挙げられる。 Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbate phosphate and magnesium ascorbate phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylreso Shinoru, oil-soluble Kamomiraekisu, oil-soluble licorice extract, Nishikawa willow extract, be mentioned as saxifrage extract, and the like plant extracts are preferred.
ビタミン類及びその誘導体類としては、レチノール、酢酸レチノール、パルミチン酸レチノール等のビタミンA類;チアミン塩酸塩、チアミン硫酸塩、リボフラビン、酢酸リボフラビン、塩酸ピリドキシン、ピリドキシンジオクタノエート、ピリドキシンジパルミテート、フラビンアデニンジヌクレオチド、シアノコバラミン、葉酸類、ニコチン酸アミド・ニコチン酸ベンジル等のニコチン酸類、コリン類等のビタミンB群類;アスコルビン酸及びそのナトリウム等の塩等のビタミンC類;ビタミンD;α、β、γ、δ−トコフェロール等のビタミンE類;パントテン酸、ビオチン等のその他ビタミン類;アスコルビン酸リン酸エステルナトリウム塩及びアスコルビン酸リン酸エステルマグネシウム塩等のアスコルビン酸リン酸エステル塩、アスコルビン酸テトライソパルミチン酸エステル・ステアリン酸アスコルビル・パルミチン酸アスコルビル・ジパルミチン酸アスコルビル等のアスコルビン酸脂肪酸エステル、アスコルビン酸エチルエーテル等のアスコルビン酸アルキルエーテル、アスコルビン酸−2−グルコシド等のアスコルビン酸グルコシド及びその脂肪酸エステル、リン酸トコフェリルアスコルビル等のアスコルビン酸誘導体;ニコチン酸トコフェロール、酢酸トコフェロール、リノール酸トコフェロール、フェルラ酸トコフェロール、トコフェロールリン酸エステル等のトコフェロール誘導体等のビタミン誘導体、トコトリエノール、その他各種ビタミン誘導体類が好ましいものとして挙げられる。 Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.
消炎剤・抗炎症剤としては、グリチルリチン酸及びその誘導体、グリチルレチン酸誘導体、サリチル酸誘導体、ヒノキチオール、グアイアズレン、アラントイン、インドメタシン、酸化亜鉛、酢酸ヒドロコーチゾン、プレドニゾン、塩酸ジフェドラミン、マレイン酸クロルフェニラミン;桃葉エキス、蓬葉エキス等の植物エキスが好ましいものとして挙げられる。育毛用薬剤・血行促進剤・刺激剤としては、センブリエキス、トウガラシチンキ、ショウキョウチンキ、ショウキョウエキス、カンタリスチンキ等の植物エキス・チンキ類;カプサイシン、ノニル酸ワレニルアミド、ジンゲロン、イクタモール、タンニン酸、ボルネオール、シクランデレート、シンナリジン、トラゾリン、アセチルコリン、ベラパミル、セファランチン、γ−オリザノール、セファランチン、ビタミンE及びニコチン酸トコフェロール・酢酸トコフェロール等の誘導体、γ−オリザノール、ニコチン酸及びニコチン酸アミド・ニコチン酸ベンジルエステル・イノシトールヘキサニコチネート、ニコチンアルコール等の誘導体、アラントイン、感光素301、感光素401、塩化カプロニウム、ペンタデカン酸モノグリセリド、フラバノノール誘導体、スチグマステロール又はスチグマスタノール及びその配糖体、ミノキシジルが好ましいものとして挙げられる。ホルモン類としては、エストラジオール、エストロン、エチニルエストラジオール、コルチゾン、ヒドロコルチゾン、プレドニゾン等が好ましいものとして挙げられる。抗しわ剤、抗老化剤、ひきしめ剤、冷感剤、温感剤、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤等のその他の薬効剤としては、レチノール類、レチノイン酸類、レチノイン酸トコフェリル;乳酸、グリコール酸、グルコン酸、フルーツ酸、サリチル酸及びその配糖体・エステル化物等の誘導体、ヒドロキシカプリン酸、長鎖α−ヒドロキシ脂肪酸、長鎖α−ヒドロキシ脂肪酸コレステリル等のα−又はβ−ヒドロキシ酸類及びその誘導体類;γ−アミノ酪酸、γ−アミノ−β−ヒドロキシ酪酸;カルニチン;カルノシン;クレアチン;セラミド類、スフィンゴシン類;カフェイン、キサンチン等及びその誘導体;コエンザイムQ10、カロチン、リコピン、アスタキサンチン、ルテイン、α−リポ酸、白金ナノコロイド、フラーレン類等の抗酸化・活性酸素消去剤;カテキン類;ケルセチン等のフラボン類;イソフラボン類;没食子酸及びエステル糖誘導体;タンニン、セサミン、プロトアントシアニジン、クロロゲン酸、リンゴポリフェノール等のポリフェノール類;ルチン及び配糖体等の誘導体;ヘスペリジン及び配糖体等の誘導体;リグナン配糖体;グラブリジン、グラブレン、リクイリチン、イソリクイリチン等のカンゾウエキス関連物質;ラクトフェリン;ショウガオール、ジンゲロール;メントール、カンファー、セドロール等の香料物質及びその誘導体;カプサイシン、バニリン等及び誘導体;ジエチルトルアミド等の昆虫忌避剤;生理活性物質とシクロデキストリン類との複合体が好ましいものとして挙げられる。 Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol / acetic acid tocopherol, derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.
植物・動物・微生物エキス類としては、アイリスエキス、アシタバエキス、アスナロエキス、アスパラガスエキス、アボガドエキス、アマチャエキス、アーモンドエキス、アルテアエキス、アルニカエキス、アロエエキス、アンズエキス、アンズ核エキス、イチョウエキス、インチコウエキス、ウイキョウエキス、ウコンエキス、ウーロン茶エキス、ウワウルシエキス、エイジツエキス、エチナシ葉エキス、エンメイソウエキス、オウゴンエキス、オウバクエキス、オウレンエキス、オオムギエキス、オタネニンジンエキス、オトギリソウエキス、オドリコソウエキス、オノニスエキス、オランダカラシエキス、オレンジエキス、海水乾燥物、海藻エキス、カキ葉エキス、カキョクエキス、加水分解エラスチン、加水分解コムギ末、加水分解シルク、カッコンエキス、カモミラエキス、油溶性カモミラエキス、カロットエキス、カワラヨモギエキス、カラスムギエキス、カルカデエキス、カンゾウエキス、油溶性カンゾウエキス、キウイエキス、キオウエキス、キクラゲエキス、キナエキス、キューカンバーエキス、キリ葉エキス、グアノシン、グアバエキス、クジンエキス、クチナシエキス、クマザサエキス、クララエキス、クルミエキス、クリエキス、グレープフルーツエキス、クレマティスエキス、黒米エキス、黒砂糖抽出物、黒酢、クロレラエキス、クワエキス、ゲンチアナエキス、ゲンノショウコエキス、紅茶エキス、酵母エキス、コウボクエキス、コーヒーエキス、ゴボウエキス、コメエキス、コメ発酵エキス、コメヌカ発酵エキス、コメ胚芽油、コンフリーエキス、コラーゲン、コケモモエキス、サイシンエキス、サイコエキス、サイタイ抽出液、サフランエキス、サルビアエキス、サボンソウエキス、ササエキス、サンザシエキス、サンシャエキス、サンショウエキス、シイタケエキス、ジオウエキス、シコンエキス、シソエキス、シナノキエキス、シモツケソウエキス、ジャトバエキス、シャクヤクエキス、ショウキュウエキス、ショウブ根エキス、シラカバエキス、白キクラゲエキス、スギナエキス、ステビアエキス、ステビア発酵物、西河柳エキス、セイヨウキズタエキス、セイヨウサンザシエキス、セイヨウニワトコエキス、セイヨウノコギリソウエキス、セイヨウハッカエキス、セージエキス、ゼニアオイエキス、センキュウエキス、センブリエキス、ソウハクヒエキス、ダイオウエキス、ダイズエキス、タイソウエキス、タイムエキス、タンポポエキス、地衣類エキス、茶エキス、チョウジエキス、チガヤエキス、チンピエキス、ティートリー油、甜茶エキス、トウガラシエキス、トウキエキス、トウキンセンカエキス、トウニンエキス、トウヒエキス、ドクダミエキス、トマトエキス、納豆エキス、ニンジンエキス、ニンニクエキス、ノバラエキス、ハイビスカスエキス、バクモンドウエキス、ハスエキス、パセリエキス、バーチエキス、蜂蜜、ハマメリスエキス、パリエタリアエキス、ヒキオコシエキス、ビサボロール、ヒノキエキス、ビフィズス菌エキス、ビワエキス、フキタンポポエキス、フキノトウエキス、ブクリョウエキス、ブッチャーブルームエキス、ブドウエキス、ブドウ種子エキス、プロポリス、ヘチマエキス、ベニバナエキス、ペパーミントエキス、ボダイジュエキス、ボタンエキス、ホップエキス、マイカイカエキス、マツエキス、マロニエエキス、ミズバショウエキス、ムクロジエキス、メリッサエキス、モズクエキス、モモエキス、ヤグルマギクエキス、ユーカリエキス、ユキノシタエキス、ユズエキス、ユリエキス、ヨクイニンエキス、ヨモギエキス、ラベンダーエキス、緑茶エキス、卵殻膜エキス、リンゴエキス、ルイボス茶エキス、レイシエキス、レタスエキス、レモンエキス、レンギョウエキス、レンゲソウエキス、ローズエキス、ローズマリーエキス、ローマカミツレエキス、ローヤルゼリーエキス、ワレモコウエキス等のエキスが好ましいものとして挙げられる。 Plant / animal / microbe extracts include iris extract, ashitaba extract, asunalo extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.
鎮痒剤としては、塩酸ジフェンヒドラミン、マレイン酸クロルフェニラミン、カンファー、サブスタンス−P阻害剤等を例示することができる。角質剥離・溶解剤としては、サリチル酸、イオウ、レゾルシン、硫化セレン、ピリドキシン等を例示することができる。制汗剤としては、クロルヒドロキシアルミニウム、塩化アルミニウム、酸化亜鉛、パラフェノールスルホン酸亜鉛等を例示することができる。清涼剤としては、メントール、サリチル酸メチル等を例示することができる。収れん剤としては、クエン酸、酒石酸、乳酸、硫酸アルミニウム・カリウム、タンニン酸等を例示することができる。酵素類としては、スーパーオキサイドディスムターゼ、カタラーゼ、塩化リゾチーム、リパーゼ、パパイン、パンクレアチン、プロテアーゼ等を例示することができる。核酸類としては、リボ核酸及びその塩、デオキシリボ核酸及びその塩、アデノシン三リン酸二ナトリウムが好ましいものとして挙げられる。 Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.
香料としては、アセチルセドレン、アミルシンナムアルデヒド、アリルアミルグリコレート、β−イオノン、イソイースーパー、イソブチルキノリン、イリス油、イロン、インドール、イランイラン油、ウンデカナール、ウンデセナール、γ−ウンデカラクトン、エストラゴール、オイゲノール、オークモス、オポポナックスレジノイド、オレンジ油、オイゲノール、オーランチオール、ガラクソリッド、カルバクロール、L−カルボン、カンファー、キャノン、キャロットシード油、クローブ油、ケイヒ酸メチル、ゲラニオール、ゲラニルニトリル、酢酸イソボルニル、酢酸ゲラニル、酢酸ジメチルベンジルカルビニル、酢酸スチラリル、酢酸セドリル、酢酸テレピネル、酢酸p-t-ブチルシクロヘキシル、酢酸ベチベリル、酢酸ベンジル、酢酸リナリル、サリチル酸イソペンチル、サリチル酸ベンジル、サンダルウッド油、サンタロール、シクラメンアルデヒド、シクロペンタデカノリド、ジヒドロジャスモン酸メチル、ジヒドロミルセノール、ジャスミンアブソリュート、ジャスミンラクトン、cis-ジャスモン、シトラール、シトロネノール、シトロネラール、シナモンバーク油、1,8−シネオール、シンナムアルデヒド、スチラックスレジノイド、セダーウッド油、セドレン、セドロール、セロリシード油、タイム油、ダマスコン、ダマセノン、チモール、チュベローズアブソリュート、デカナール、デカラクトン、テルピネオール、γ−テルピネン、トリプラール、ネロール、ノナナール、2,6−ノナジエノール、ノナラクトン、パチョリアルコール、バニラアブソリュート、バニリン、バジル油、パチョリ油、ヒドロキシシトロネラール、α−ピネン、ピペリトン、フェネチルアルコール、フェニルアセトアルデヒド、プチグレン油、ヘキシルシンナムアルデヒド、cis-3-ヘキセノール、ペルーバルサム、ベチバー油、ベチベロール、ペパーミント油、ペパー油、ヘリオトロピン、ベルガモット油、ベンジルベンゾエート、ボルネオール、ミルレジノイド、ムスクケトン、メチルノニルアセトアルデヒド、γ−メチルヨノン、メントール、L−メントール、L−メントン、ユーカリ油、β−ヨノン、ライム油、ラベンダー油、D−リモネン、リナロール、リラール、リリアール、レモン油、ローズアブソリュート、ローズオキシド、ローズ油、ローズマリー油、各種精油等の合成香料及び天然香料並びに各種調合香料が好ましいものとして挙げられる。 As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.
色素・着色剤・染料・顔料としては、褐色201号、黒色401号、紫色201号、紫色401号、青色1号、青色2号、青色201号、青色202号、青色203号、青色204号、青色205号、青色403号、青色404号、緑色201号、緑色202号、緑色204号、緑色205号、緑色3号、緑色401号、緑色402号、赤色102号、赤色104−1号、赤色105−1号、赤色106号、赤色2号、赤色201号、赤色202号、赤色203号、赤色204号、赤色205号、赤色206号、赤色207号、赤色208号、赤色213号、赤色214号、赤色215号、赤色218号、赤色219号、赤色220号、赤色221号、赤色223号、赤色225号、赤色226号、赤色227号、赤色228号、赤色230−1号、赤色230−2号、赤色231号、赤色232号、赤色3号、赤色401号、赤色404号、赤色405号、赤色501号、赤色502号、赤色503号、赤色504号、赤色505号、赤色506号、橙色201号、橙色203号、橙色204号、橙色205号、橙色206号、橙色207号、橙色401号、橙色402号、橙色403号、黄色201号、黄色202−1号、黄色202−2号、黄色203号、黄色204号、黄色205号、黄色4号、黄色401号、黄色402号、黄色403−1号、黄色404号、黄色405号、黄色406号、黄色407号、黄色5号等の法定色素;Acid Red 14等のその他酸性染料;Arianor Sienna Brown、Arianor Madder Red、Arianor
Steel Blue、Arianor Straw Yellow等の塩基染料;HC Yellow 2、HC Yellow 5、HC Red 3、4-hydoxypropylamino-3-nitrophenol、N,N’-bis(2-hydroxyethyl)-2-nitro-p-
phenylenediamine、HC Blue 2、Basic Blue 26等のニトロ染料;分散染料;二酸化チタン、酸化亜鉛等の無機白色顔料;酸化鉄(ベンガラ)、チタン酸鉄等の無機赤色系顔料;γ−酸化鉄等の無機褐色系顔料;黄酸化鉄、黄土等の無機黄色系顔料;黒酸化鉄、低次酸化チタン等の無機黒色系顔料;マンゴバイオレット、コバルトバイオレット等の無機紫色系顔料;酸化クロム、水酸化クロム、チタン酸コバルト等の無機緑色系顔料;群青、紺青等の無機青色系顔料;酸化チタンコーテッドマイカ、酸化チタンコーテッドオキシ塩化ビスマス、酸化チタンコーテッドタルク、着色酸化チタンコーテッドマイカ、オキシ塩化ビスマス、魚鱗箔等のパール顔料;アルミニウムパウダー、カッパーパウダー、金等の金属粉末顔料;表面処理無機及び金属粉末顔料;赤色201号、赤色202号、赤色204号、赤色205号、赤色220号、赤色226号、赤色228号、赤色405号、橙色203号、橙色204号、黄色205号、黄色401号、青色404号、赤色3号、赤色104号、赤色106号、赤色227号、赤色230号、赤色401号、赤色505号、橙色205号、黄色4号、黄色5号、黄色202号、黄色203号、緑色3号、青色1号等のジルコニウム、バリウム又はアルミニウムレーキ等の有機顔料;表面処理有機顔料;アスタキサンチン、アリザリン等のアントラキノン類、アントシアニジン、β−カロチン、カテナール、カプサンチン、カルコン、カルサミン、クエルセチン、クロシン、クロロフィル、クルクミン、コチニール、シコニン等のナフトキノン類、ビキシン、フラボン類、ベタシアニジン、ヘナ、ヘモグロビン、リコピン、リボフラビン、ルチン等の天然色素・染料;p−フェニレンジアミン、トルエン−2,5−ジアミン、o−,m−,若しくはp−アミノフェノール、m−フェニレンジアミン、5−アミノ−2−メチルフェノール、レゾルシン、1−ナフトール、2,6−ジアミノピリジン等及びその塩等の酸化染料中間体及びカップラー;インドリン等の自動酸化型染料;ジヒドロキシアセトンが好ましいものとして挙げられる。
As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Arianor Sienna Brown, Arianor Madder Red, Arianor
Basic dyes such as Steel Blue and Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-
Nitro dyes such as phenylenediamine, HC Blue 2 and Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (Bengara) and iron titanate; and γ-iron oxide Inorganic brown pigments; inorganic yellow pigments such as yellow iron oxide and ocher; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; chromium oxide and chromium hydroxide Inorganic green pigments such as cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil Pearl powder such as aluminum powder, copper powder, metal powder pigment such as gold; surface treatment inorganic and metal powder pigment; red 01, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404 Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1 organic pigments such as zirconium, barium or aluminum lakes; Surface treatment organic pigments; Naphthoquinones such as chlorophyll, curcumin, cochineal, shikonin, bixin, flavo Natural pigments and dyes such as amines, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylene Oxidative dye intermediates and couplers such as diamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; auto-oxidizing dyes such as indoline; Can be mentioned.
水としては、常水、精製水の他、硬水、軟水、天然水、海洋深層水、電解アルカリイオン水、電解酸性イオン水、イオン水、クラスター水が好ましいものとして挙げられる。 Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.
これらの他、化粧品原料基準、化粧品種別配合成分規格、日本化粧品工業連合会成分表示名称リスト、INCI辞書(The International Cosmetic Ingredient Dictionary and Handbook)、医薬部外品原料規格、日本薬局方、医薬品添加物規格、食品添加物公定書等に記載されている成分、及び、国際特許分類IPCがA61K7及びA61K8の分類に属する日本国及び諸外国特許公報及び特許公開公報(公表公報・再公表を含む)に記載されている成分等、公知の化粧料成分、医薬品成分、食品成分などを、公知の組み合わせ及び配合比・配合量で含有させることが可能である。 In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.
本発明のセラミド誘導体を含有する化粧料の種類としては、毛髪用化粧料、基礎化粧料、メーキャップ化粧料、芳香化粧料、ボディ化粧料、軟膏等の皮膚外用剤が好ましいものとして挙げられる。本発明の化粧料は、通常の方法に従って製造することができる。 Examples of the cosmetics containing the ceramide derivative of the present invention include skin external preparations such as hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and ointments. The cosmetic of the present invention can be produced according to a usual method.
本発明のセラミド誘導体を含有する化粧料の種類を更に詳細に説明すると、毛髪用化粧料としては、オイルシャンプー、クリームシャンプー、コンディショニングシャンプー、ふけ用シャンプー、ヘアカラー用シャンプー、リンス一体型シャンプー等のシャンプー;リンス、トリートメント、ヘアパック、ヘアフォーム、ヘアムース、ヘアスプレー、ヘアミスト、ヘアワックス、ヘアジェル、ウォーターグリース、セットローション、カラーローション、ヘアトニック、ヘアリキッド、ポマード、チック、ヘアクリーム、ヘアブロー、枝毛コート、ヘアオイル、パーマネントウェーブ用剤、ストレートパーマ剤、酸化染毛剤、ヘアブリーチ、ヘアカラープレトリートメント、ヘアカラーアフタートリートメント、パーマプレトリートメント、パーマアフタートリートメント、ヘアマニキュア、育毛剤が好ましいものとして挙げられる。 The types of cosmetics containing the ceramide derivative of the present invention will be described in more detail. Examples of hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, and rinse-integrated shampoos. Shampoo; rinse, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow, split ends Coat, hair oil, permanent wave agent, straight permanent agent, oxidation hair dye, hair bleach, hair color pretreatment, hair color after treatment, permanent pretreatment, Over Ma after treatments, hair manicure, and as hair growth agents are preferred.
基礎化粧料としては、柔軟化粧水、収れん化粧水、洗浄用化粧水、多層式化粧水等の化粧水;エモリエントローション、モイスチャーローション、ミルキィーローション、ナリシングローション、ナリシングミルク、スキンモイスチャー、モイスャーエマルション、マッサージローション、クレンジングローション、プロテクトエマルション、サンプロテクト、サンプロテクター、UVケアミルク、サンスクリーン、メーキャップローション、角質スムーザー、エルボーローション、ハンドローション、ボディローション等の乳液;エモリエントクリーム、栄養クリーム、ナリシングクリーム、バニシングクリーム、モイスチャークリーム、ナイトクリーム、マッサージクリーム、クレンジングクリーム、メーキャップクリーム、ベースクリーム、プレメーキャップクリーム、サンスクリーンクリーム、サンタンクリーム、除毛クリーム、デオドラントクリーム、シェービングクリーム、角質軟化クリーム等のクリーム;モイスチャージェル等のジェル;保湿エッセンス、美白エッセンス、紫外線防止エッセンス等のエッセンス;リポソーム美容液、リポソーム化粧水等のリポソーム化粧品類;ピールオフパック、粉末パック、ウォッシングパック、オイルパック、クレンジングマスク等のパック・マスク類;クレンジングフォーム、クレンジングクリーム、クレンジングミルク、クレンジングローション、クレンジングジェル、クレンジングオイル、クレンジングマスク、洗粉、洗顔パウダー等の洗顔料;化粧石鹸、透明石鹸、薬用石鹸、液状石鹸、ひげそり石鹸、合成化粧石鹸等の石鹸が好ましいものとして挙げられる。 Basic cosmetics include soft lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, nari Thing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, sun makeup cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; liposome Liposome cosmetics such as beauty essence and liposome lotion; Peel-off packs, powder packs, washing packs, oil packs, cleansing masks and other packs and masks; cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels, cleansing oils , Cleansing mask, washing powder, face washing powder, etc .; cosmetic soap, transparent soap, medicated soap, liquid soap, shaving soap, synthetic cosmetic soap Soap can be mentioned as preferred.
メーキャップ化粧料としては、白粉・打粉類、ファンデーション類、口紅類、リップグロス、頬紅類、アイライナー、マスカラ、アイシャドー、眉墨、アイブロー、ネイルエナメル、エナメルリムーバー、ネイルトリートメントが好ましいものとして挙げられる。 Examples of makeup cosmetics that may be preferably used include white powder, dusts, foundations, lipsticks, lip gloss, blushers, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment.
芳香化粧料としては、香水、パフューム、パルファム、オードパルファム、オードトワレ、オーデコロン、練香水、芳香パウダー、香水石鹸、ボディローション、バスオイルが好ましいものとして挙げられる。 Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.
ボディ化粧料としては、ボディシャンプー等のボディ洗浄料;デオドラントローション、デオドラントパウダー、デオドラントスプレー、デオドラントスティック等の防臭化粧料;脱色剤、脱毛・除毛剤;浴用剤;虫よけスプレー等のインセクトリペラーが好ましいものとして挙げられる。 Body cosmetics such as body shampoos; deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics; decoloring agents, hair removal / hair removal agents; bathing agents; insect repellents A repeller is preferred.
また、皮膚外用剤としては、軟膏剤、貼付剤、ローション剤、リニメント剤、液状塗布剤などの剤型で用いることができる。また、歯磨き、マウスウォッシュ等の口腔内化粧料としても用いることが出来る。 Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.
本発明のセラミド誘導体を含有する化粧料の剤型としては、水中油(O/W)型、油中水(W/O)型、W/O/W型、O/W/O型等の乳化型化粧料、油性化粧料、固形化粧料、液状化粧料、練状化粧料、スティック状化粧料、揮発性油型化粧料、粉状化粧料、ゼリー状化粧料、ジェル状化粧料、ペースト状化粧料、乳化高分子型化粧料、シート状化粧料、ミスト状化粧料、スプレー型化粧料等の剤型が好ましいものとして挙げられる。 The cosmetic dosage forms containing the ceramide derivative of the present invention include oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type and the like. Emulsified cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, kneaded cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, pastes Preferable examples include dosage forms such as a cosmetic, an emulsified polymer cosmetic, a sheet cosmetic, a mist cosmetic, and a spray cosmetic.
以下、本発明につき実施例を用いてより詳細に説明するが、本発明はこれら実施例に限定されるものでない。 EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example, this invention is not limited to these Examples.
合成例1 ジラウリン酸セラミド2の合成
攪拌機、温度計、ガス導入管を備えた300mLの反応器に、セラミド2(高砂香料工業社製、商品名TIC−001)20g(0.0352モル)、ピリジン6.41g(0.0810モル)、トルエン92gを仕込み、窒素雰囲気下60℃でラウリン酸クロライド16.95g(0.0775モル)を滴下し、6時間反応させた。得られた反応液中に水50g、トルエン80g、IPA40gを仕込み、目的物をトルエン相へ抽出し、5%水酸化ナトリウム液で脱酸後、水洗を3回行った。トルエン相を減圧下で濃縮し目的物の化合物30gを固形物として得た。得られた固形物は白色固体で、酸価:0.6、水酸基価:0.4であった。
赤外吸収スペクトル(KBr法):2913、2849、1736、1640、1533、1468、1190cm−1
Synthesis Example 1 Synthesis of ceramide dilaurate 2 In a 300 mL reactor equipped with a stirrer, a thermometer, and a gas introduction tube, 20 g (0.0352 mol) of ceramide 2 (trade name TIC-001, manufactured by Takasago International Corporation), pyridine 6.41 g (0.0810 mol) and 92 g of toluene were charged, and 16.95 g (0.0775 mol) of lauric acid chloride was added dropwise at 60 ° C. in a nitrogen atmosphere and reacted for 6 hours. 50 g of water, 80 g of toluene, and 40 g of IPA were charged into the resulting reaction solution, and the target product was extracted into the toluene phase, deacidified with 5% sodium hydroxide solution, and then washed with water three times. The toluene phase was concentrated under reduced pressure to obtain 30 g of the desired compound as a solid. The obtained solid was a white solid having an acid value of 0.6 and a hydroxyl value of 0.4.
Infrared absorption spectrum (KBr method): 2913, 2849, 1736, 1640, 1533, 1468, 1190 cm −1
合成例2 ジイソパルミチン酸セラミド2の合成
攪拌機、温度計、ガス導入管を備えた200mLの反応器に、セラミド2(高砂香料工業社製、商品名TIC−001)10g(0.0176モル)、ピリジン3.90g(0.0493モル)、トルエン46gを仕込み、窒素雰囲気下60℃でイソパルミチン酸クロライド12.58g(0.0458モル)を滴下し、6時間反応させた。得られた反応液中に水25g、トルエン40g、IPA20gを仕込み、目的物をトルエン相へ抽出し、5%水酸化ナトリウム液で脱酸後、水洗を3回行った。トルエン相を減圧下で濃縮し目的物の化合物18gを固形物として得た。得られた固形物は白色固体で、酸価:0.7、水酸基価:0.5であった。
赤外吸収スペクトル(KBr法):2913、2849、1722、1650、1531、1470cm−1
Synthesis Example 2 Synthesis of diisopalmitic acid ceramide 2 In a 200 mL reactor equipped with a stirrer, a thermometer and a gas introduction tube, 10 g (0.0176 mol) of ceramide 2 (trade name TIC-001, manufactured by Takasago International Corporation) Then, 3.90 g (0.0493 mol) of pyridine and 46 g of toluene were charged, and 12.58 g (0.0458 mol) of isopalmitic acid chloride was added dropwise at 60 ° C. in a nitrogen atmosphere and reacted for 6 hours. 25 g of water, 40 g of toluene, and 20 g of IPA were charged into the resulting reaction solution, and the target product was extracted into a toluene phase, deoxidized with 5% sodium hydroxide solution, and washed with water three times. The toluene phase was concentrated under reduced pressure to obtain 18 g of the desired compound as a solid. The obtained solid was a white solid having an acid value of 0.7 and a hydroxyl value of 0.5.
Infrared absorption spectrum (KBr method): 2913, 2849, 1722, 1650, 1531, 1470 cm −1
融点測定
合成例1及び合成例2の化合物について示差走査型熱量計(島津製作所製、DSC−50)を用いて融点の測定を行った。比較としてセラミド2についても測定を行った。測定で得られる吸熱ピークのピークトップ温度を融点とし、結果を表1に示した。
Melting | fusing point measurement About the compound of the synthesis example 1 and the synthesis example 2, the melting | fusing point was measured using the differential scanning calorimeter (The Shimadzu Corporation make, DSC-50). As a comparison, measurement was also performed for ceramide 2. The peak top temperature of the endothermic peak obtained by the measurement was taken as the melting point, and the results are shown in Table 1.
溶解性試験
合成例1及び合成例2の化合物について油剤への溶解性を評価した。比較としてセラミド2を用いた。評価は以下のように行い、結果は表2に示した。
(評価方法)
流動パラフィン、トリ2−エチルヘキサン酸グリセリル、2−エチルへキサン酸セチル各100gに合成例1、合成例2の化合物及びセラミド2それぞれを0.05g加え、一旦80℃まで加熱し、その後20℃及び5℃まで冷却し、各温度で24時間保管後のサンプルについて目視で不溶物の有無を確認した。
Solubility test About the compound of the synthesis example 1 and the synthesis example 2, the solubility to an oil agent was evaluated. Ceramide 2 was used as a comparison. Evaluation was performed as follows, and the results are shown in Table 2.
(Evaluation method)
0.05 g of each of the compound of Synthesis Example 1 and Synthesis Example 2 and Ceramide 2 was added to 100 g of liquid paraffin, glyceryl tri-2-ethylhexanoate, and cetyl 2-ethylhexanoate, and once heated to 80 ° C., then 20 ° C. The sample was cooled to 5 ° C. and stored at each temperature for 24 hours, and the presence or absence of insoluble matter was confirmed visually.
表1、表2の結果より、本発明で使用されるセラミド誘導体である合成例1及び合成例2の化合物は、セラミド2と比較し融点は低く、また、各種油剤への溶解性も高いことから、化粧料への配合が容易である。 From the results of Tables 1 and 2, the compounds of Synthesis Example 1 and Synthesis Example 2, which are ceramide derivatives used in the present invention, have a lower melting point than ceramide 2 and high solubility in various oils. Therefore, it can be easily blended into cosmetics.
安定性試験
表3、表4の組成で、合成例1、合成例2の化合物、及び、セラミド2を配合した水分散物を作製した。得られた水分散物について、25℃及び40℃で30日間静置保管し、水分散物の安定性を目視で評価した。結果は、表3、表4の下段に併記した。結果より、セラミド2を配合した水分散物(水分散物3、7)は保管中に沈殿が生じたのに対して、本発明のセラミド誘導体を配合した水分散物(水分散物1、2、5、6、)はいずれも沈殿等の外観変化は見られなかった。このことより、本発明のセラミド誘導体は処方中での安定性が優れることが分かった。
(水分散物調製方法)
A部を約80℃で攪拌混合した。予め80℃に加温したA部をB部に加え、ホモミキサーを用いて攪拌(8000rpm、30分)後、室温まで冷却した。
Stability test The aqueous dispersion which mix | blended the compound of the synthesis example 1 and the synthesis example 2, and the ceramide 2 with the composition of Table 3 and Table 4 was produced. About the obtained aqueous dispersion, it stood still for 30 days at 25 degreeC and 40 degreeC, and the stability of the aqueous dispersion was evaluated visually. The results are shown in the lower part of Tables 3 and 4. From the results, the aqueous dispersion containing the ceramide 2 (aqueous dispersions 3 and 7) was precipitated during storage, whereas the aqueous dispersion containing the ceramide derivative of the present invention (the aqueous dispersions 1 and 2). No changes in appearance such as precipitation were observed in all of Nos. 5, 6, and). This indicates that the ceramide derivative of the present invention is excellent in stability during formulation.
(Method for preparing aqueous dispersion)
Part A was stirred and mixed at about 80 ° C. A part preliminarily heated to 80 ° C. was added to part B, and after stirring (8000 rpm, 30 minutes) using a homomixer, the mixture was cooled to room temperature.
皮膚保湿能評価
表3の水分散物1、水分散物2及び水分散物4を用いて、表5の組成で実施例1、実施例2及び比較例1の皮膚化粧料を作製した。得られた皮膚化粧料について、角層水分量回復試験を実施し、皮膚保湿能を評価した。試験方法は下記のように行い、結果は表5の下段に併記した。
(試験方法)
パネラー10名の前腕内側部を試験部位とし、恒温恒湿室(室温22℃、湿度45%)にて30分間馴化後、角層水分量測定装置(IBS社製SKICON−200)を用いて、予め各試験部位(面積4cm2)のコンダクタンスを測定した(初期値)。その後、試験部位をアセトン/エーテル=1:1液で処理して肌荒れを惹起し、肌荒れ部位に皮膚化粧料を1日2回、3日間連続で塗布した後、初期値と同条件で塗布部位のコンダクタンスを測定した。結果は、初期のコンダクタンスを100とした際の相対値で示した。
Skin moisturizing ability evaluation Using the aqueous dispersion 1, the aqueous dispersion 2 and the aqueous dispersion 4 in Table 3, skin cosmetics of Examples 1, 2 and Comparative Example 1 having the compositions shown in Table 5 were prepared. The obtained skin cosmetic was subjected to a stratum corneum moisture recovery test to evaluate the skin moisturizing ability. The test method was performed as follows, and the results are shown in the lower part of Table 5.
(Test method)
The inner part of the forearm of 10 panelists was used as a test site, and after acclimatization for 30 minutes in a constant temperature and humidity chamber (room temperature 22 ° C., humidity 45%), using a stratum corneum moisture measuring device (SKICON-200 manufactured by IBS) The conductance of each test site (area 4 cm 2 ) was measured in advance (initial value). Thereafter, the test site was treated with acetone / ether = 1: 1 solution to cause rough skin, and the skin cosmetic was applied to the rough skin site twice a day for 3 consecutive days, and then applied under the same conditions as the initial values. The conductance was measured. The results are shown as relative values when the initial conductance is 100.
表5の結果より、本発明のセラミド誘導体を配合した皮膚化粧料は、皮膚の水分量を塗布前より向上させ、その効果は未配合品に比較して非常に高いものであった。よって、本発明のセラミド誘導体を配合した皮膚化粧料は、皮膚に対して優れた保湿作用を有することが分かった。 From the results shown in Table 5, the skin cosmetic containing the ceramide derivative of the present invention improved the moisture content of the skin before application, and the effect was very high compared to the unmixed product. Therefore, it turned out that the skin cosmetics which mix | blended the ceramide derivative of this invention have the outstanding moisturizing effect with respect to skin.
毛髪ダメージ回復能評価
表4の水分散物5、水分散物6及び水分散物8を用いて、表6の組成で実施例3、実施例4及び比較例2の毛髪化粧料を作製した。得られた毛髪化粧料について、毛髪破断強度試験を実施し、毛髪ダメージ回復能を評価した。試験方法は以下のように行い、結果は表6の下段に併記した。
(試験方法)
健常黒髪人毛に市販パーマネントウェーブ処理剤にてパーマネント処理を1回、市販2剤式酸化染毛剤にて染毛処理を2回行い、損傷毛50本の毛束4束を作製した。実施例3、実施例4及び比較例2の毛髪化粧料30gに毛束を浸漬し、25℃にて1分間処理した後、ラウレス硫酸Na3%液にて洗浄、水洗した。室温25℃、湿度45%の条件下、24時間放置後、毛髪20本採取し、ひっぱり試験機(レオメーター/不動工業社製)にて毛髪破断強度を測定した。結果は未損傷毛(健常毛)の毛髪強度を100とした際の相対値として示した。
Hair damage recovery ability evaluation Using the aqueous dispersion 5, the aqueous dispersion 6 and the aqueous dispersion 8 shown in Table 4, hair cosmetics of Examples 3, 4 and Comparative Example 2 were prepared with the compositions shown in Table 6. About the obtained hair cosmetics, the hair breaking strength test was implemented and the hair damage recovery ability was evaluated. The test method was performed as follows, and the results are shown in the lower part of Table 6.
(Test method)
Healthy black hair was subjected to permanent treatment once with a commercially available permanent wave treating agent and twice with a commercially available two-component oxidative hair dye to produce 4 bundles of 50 damaged hair. The hair bundle was immersed in 30 g of the hair cosmetic composition of Example 3, Example 4 and Comparative Example 2, treated at 25 ° C. for 1 minute, then washed with 3% laureth sulfate Na solution and washed with water. After standing for 24 hours at room temperature of 25 ° C. and humidity of 45%, 20 hairs were collected, and the hair breaking strength was measured with a pulling tester (Rheometer / Fudo Kogyo Co., Ltd.). The results are shown as relative values when the hair strength of undamaged hair (normal hair) is taken as 100.
表6の結果より、本発明のセラミド誘導体を配合した毛髪化粧料は、毛髪破断強度を健常毛とほぼ同程度まで回復させ、またその効果は未配合品に比較して高いものであった。よって、本発明のセラミド誘導体を配合した毛髪化粧料は、高い毛髪ダメージ回復効果を有することが分かった。 From the results shown in Table 6, the hair cosmetic containing the ceramide derivative of the present invention recovered the hair breaking strength to almost the same level as that of healthy hair, and the effect was higher than that of the unblended product. Therefore, it turned out that the hair cosmetics which mix | blended the ceramide derivative of this invention have a high hair damage recovery effect.
実施例5 乳液
下記処方の乳液を調製した。この乳液は、適度な粘度を示し、使用感に優れ、皮膚に潤いを与え皮膚の乾燥を防ぐものであり、これらの効果は長時間持続するものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
合成例1の化合物 0.10
セタノール 1.00
スクワラン 0.50
ダイズ油 0.50
ベヘネス−30 0.25
セバシン酸ジエチルヘキシル 0.50
トコフェロール 0.05
B部
ステアロキシヒドロキシプロピルメチルセルロース 0.40
精製水 20.00
C部
HEDTA−3Na(ヒドロキシエチルエチレンジアミン三酢酸)0.01
ヒアルロン酸Na 0.03
ソルビトール 6.00
コハク酸 0.03
コハク酸Na 適量
ジグリセリン 0.15
アスコルビルエチル 0.50
フェノキシエタノール 0.20
メチルパラベン 0.15
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部を約70℃に加温し、均一に溶解させた。B部を攪拌して粘性の液とした。A部に約70℃に加温したC部を加え、攪拌して乳化した後、冷却し約50℃でB部を加え、攪拌して均一に溶解し、コハク酸NaにてpH6.0とした。
Example 5 Emulsion An emulsion having the following formulation was prepared. This emulsion showed moderate viscosity, excellent usability, moisturizes the skin and prevents the skin from drying, and these effects last for a long time.
Component Blending amount (% by weight)
--------------------------------------
Part A Compound of Synthesis Example 1 0.10
Cetanol 1.00
Squalane 0.50
Soybean oil 0.50
Behenez-30 0.25
Diethylhexyl sebacate 0.50
Tocopherol 0.05
Part B stearoxyhydroxypropylmethylcellulose 0.40
Purified water 20.00
Part C HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.01
Hyaluronic acid Na 0.03
Sorbitol 6.00
Succinic acid 0.03
Sodium succinate appropriate amount diglycerin 0.15
Ascorbyl ethyl 0.50
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Add part C heated to about 70 ° C. to part A, stir to emulsify, then cool and add part B at about 50 ° C., stir to dissolve uniformly, and pH 6.0 with Na succinate. did.
実施例6 クリーム
下記処方のクリームを調製した。このクリームは、適度な粘度を示し、使用感に優れ、皮膚に潤いを与え皮膚の乾燥を防ぐものであり、これらの効果は長時間持続するものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
合成例1の化合物 0.50
バチルアルコール 2.00
スクワラン 2.00
トリ2−エチルへキサン酸グリセリル 3.00
ステアリン酸 1.00
マカデミアナッツ油脂肪酸フィトステリル 1.00
天然ビタミンE 0.05
ベヘニルアルコール 2.00
ステアリン酸グリセリル 1.00
エチルパラベン 0.15
メチルポリシロキサン 0.50
ポリオキシエチレンセチルエーテル 2.00
Phytocompo−PP(日本精化) 0.50
B部
(アクリロイルジメチルタウリンアンモニウム/
メタクリル酸ベヘネス−25)クロスポリマー 0.20
精製水 20.00
C部
コハク酸 0.01
コハク酸Na 適量
1,3−ブチレングリコール 0.15
加水分解コラーゲン 0.20
ヒドロキシエタンジホスホン酸液 0.03
濃グリセリン 2.00
メチルパラベン 0.10
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部を約70℃に加温し、均一に溶解させた。B部を攪拌して粘性の液とした。C部を約70℃に加温し、均一に溶解させた。A部にC部を加え攪拌して、乳化した後冷却し、約50℃でB部を加え、攪拌して均一に溶解し、コハク酸NaにてpH6.0とした。
Example 6 Cream A cream having the following formulation was prepared. This cream has an appropriate viscosity, is excellent in feeling of use, moisturizes the skin and prevents the skin from drying, and these effects last for a long time.
Component Blending amount (% by weight)
--------------------------------------
Part A Compound of Synthesis Example 1 0.50
Batyl alcohol 2.00
Squalane 2.00
Glyceryl tri-2-ethylhexanoate 3.00
Stearic acid 1.00
Macadamia nut oil fatty acid phytosteryl 1.00
Natural vitamin E 0.05
Behenyl alcohol 2.00
Glyceryl stearate 1.00
Ethylparaben 0.15
Methyl polysiloxane 0.50
Polyoxyethylene cetyl ether 2.00
Phytocompo-PP (Nippon Seika) 0.50
Part B (Acryloyldimethyltaurate ammonium /
Methenic acid behenes-25) Cross polymer 0.20
Purified water 20.00
Part C Succinic acid 0.01
Sodium succinate appropriate amount 1,3-butylene glycol 0.15
Hydrolyzed collagen 0.20
Hydroxyethane diphosphonic acid solution 0.03
Concentrated glycerin 2.00
Methylparaben 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was heated to about 70 ° C. and dissolved uniformly. C part was added to A part, stirred and emulsified and then cooled. Part B was added at about 50 ° C. and stirred to dissolve uniformly, and the pH was adjusted to 6.0 with Na succinate.
実施例7 乳液
下記処方の乳液を調製した。この乳液は、適度な粘度を示し、使用感に優れ、皮膚に潤いを与え皮膚の乾燥を防ぐものであり、これらの効果は長時間持続するものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
合成例2の化合物 0.15
ステアリン酸ソルビタン 0.50
ステアリン酸PEG−10 0.50
ポリソルベート60 0.50
エチルへキサン酸セチル 3.70
セタノール 1.20
ジメチコン(10cs) 1.00
プロピルパラベン 0.10
B部
(アクリロイルジメチルタウリンアンモニウム/VP)コポリマー 0.05
ステアロキシヒドロキシプロピルメチルセルロース 0.10
キサンタンガム 0.10
カルボマー 0.15
水酸化K 0.06
精製水 20.00
C部
1,3−ブチレングリコール 3.00
シクロヘキサンジカルボン酸ビスエトキシジグリコール 1.00
グリセリン 1.00
フェノキシエタノール 0.20
メチルパラベン 0.15
フィチン酸 0.50
クエン酸 0.01
クエン酸Na 適量
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部を約70℃に加温し、均一に溶解させた。B部を攪拌して粘性の液とした。C部を約70℃に加温し、均一に溶解させた。A部にC部を加え、ホモミキサーにて乳化した後冷却し、約50℃でB部を加え、攪拌して均一に溶解し、クエン酸Naにて、pH6.0とした。
Example 7 Emulsion An emulsion having the following formulation was prepared. This emulsion showed moderate viscosity, excellent usability, moisturizes the skin and prevents the skin from drying, and these effects last for a long time.
Component Blending amount (% by weight)
--------------------------------------
Part A Compound of Synthesis Example 2 0.15
Sorbitan stearate 0.50
PEG-10 stearate 0.50
Polysorbate 60 0.50
Cetyl ethylhexanoate 3.70
Cetanol 1.20
Dimethicone (10cs) 1.00
Propylparaben 0.10
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.05
Stearoxyhydroxypropylmethylcellulose 0.10
Xanthan gum 0.10
Carbomer 0.15
Hydroxide K 0.06
Purified water 20.00
Part C 1,3-butylene glycol 3.00
Cyclohexanedicarboxylic acid bisethoxydiglycol 1.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Phytic acid 0.50
Citric acid 0.01
Na citrate Appropriate amount Purified water Total amount to be 100 ------------------------------------ −
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was heated to about 70 ° C. and dissolved uniformly. C part was added to part A, emulsified with a homomixer and then cooled. Part B was added at about 50 ° C., stirred and dissolved uniformly, and adjusted to pH 6.0 with sodium citrate.
実施例8 化粧水
下記処方の化粧水を調製した。この化粧水は、使用感、保湿感に優れ、皮膚を柔軟にしみずみずしくなめらかなうるおいのある肌を保ち、これらの効果は長時間持続するものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
キサンタンガム 0.30
カルボマー 0.20
Tremoist−TP(日本精化) 0.20
精製水 20.00
B部
合成例1の化合物 0.05
(エイコサン二酸/テトラデカン二酸)ポリグリセリル−10 1.00
BG 1.00
グリセリン 2.00
ユビキノン 0.03
トリ2−エチルへキサン酸グリセリル 0.08
テトラオレイン酸ソルベス−60 0.12
PEG−60水添ヒマシ油 0.03
イソステアリン酸PEG−30グリセリル 0.03
メチルパラベン 0.20
香料 微量
エタノール 7.00
C部
クエン酸 0.01
クエン酸Na 適量
グルタミン酸ジ酢酸4Na 0.80
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部を攪拌して粘性の液とした。B部を約70℃に加温し、均一に溶解させた。約50℃でC部にB部を加え、攪拌して均一に溶解し、さらに、A部を加え、攪拌して均一に溶解し、クエン酸Naにて、pH6.0とした。
Example 8 Lotion Toner lotion having the following formulation was prepared. This skin lotion was excellent in feeling of use and moisturizing, kept the skin soft and fresh and smooth and moisturized, and these effects lasted for a long time.
Component Blending amount (% by weight)
--------------------------------------
Part A xanthan gum 0.30
Carbomer 0.20
Tremoist-TP (Nippon Seika) 0.20
Purified water 20.00
Part B Compound of Synthesis Example 1 0.05
(Eicosanedioic acid / Tetradecanedioic acid) Polyglyceryl-10 1.00
BG 1.00
Glycerin 2.00
Ubiquinone 0.03
Glyceryl tri-2-ethylhexanoate 0.08
Tetraoleic acid Solves-60 0.12
PEG-60 hydrogenated castor oil 0.03
PEG-30 glyceryl isostearate 0.03
Methylparaben 0.20
Fragrance Trace amount Ethanol 7.00
Part C Citric acid 0.01
Sodium citrate appropriate amount glutamic acid diacetate 4Na 0.80
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was stirred to obtain a viscous liquid. Part B was heated to about 70 ° C. and dissolved uniformly. Part B was added to part C at about 50 ° C. and stirred to dissolve uniformly. Further, part A was added and stirred to dissolve uniformly, and the pH was adjusted to 6.0 with Na citrate.
実施例9 ヘアミスト
下記処方のヘアミストを調製した。このヘアミストは、べたつかず、毛髪につるつるとした良好な感触となめらかな指通りを付与することができるものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
合成例1の化合物 0.10
Plandool−H(日本精化) 0.30
SUCRAPH AG−8(日本精化) 0.20
ジメチコン 0.20
セトリモニウムクロリド(30%) 4.00
エタノール 8.00
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
各成分を均一に撹拌、混合した。
Example 9 Hair mist Hair mist having the following formulation was prepared. This hair mist was not sticky and was able to give a smooth feel to the hair and smooth touch.
Component Blending amount (% by weight)
--------------------------------
Compound of Synthesis Example 1 0.10
Plandool-H (Nippon Seika) 0.30
SUCRAPH AG-8 (Nippon Seika) 0.20
Dimethicone 0.20
Cetrimonium chloride (30%) 4.00
Ethanol 8.00
Purified water Total amount of 100 --------------------------------
(Preparation method)
Each component was stirred and mixed uniformly.
実施例10 ヘアエッセンス
下記処方のヘアエッセンスを調製した。このヘアエッセンスは、さっぱりとした感触で、べたつかず、毛髪に潤いとすべり感を付与できるものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
合成例1の化合物 0.20
シクロヘキサンジカルボン酸ビスエトキシジグリコール 1.00
セタノール 1.00
ステアルトリモニウムクロリド(63%) 0.80
ジココジモニウムクロリド(75%) 2.80
テトラオレイン酸ソルベス−60 1.00
PEG−40水添ヒマシ油 0.20
B部
メチルパラベン 0.10
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部を約80℃に加温して溶解させた。別の容器にB部をとり、約80℃に加温して溶解させた。A部にB部を徐々に加えて均一に混合した。
Example 10 Hair Essence A hair essence having the following formulation was prepared. This hair essence was refreshing and non-sticky and could give moisture and a feeling of slipping.
Component Blending amount (% by weight)
--------------------------------
Part A Compound of Synthesis Example 1 0.20
Cyclohexanedicarboxylic acid bisethoxydiglycol 1.00
Cetanol 1.00
Steartrimonium chloride (63%) 0.80
Dicocodimonium chloride (75%) 2.80
Tetraoleic acid Solves-60 1.00
PEG-40 hydrogenated castor oil 0.20
Part B Methylparaben 0.10
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was taken in another container and dissolved by heating to about 80 ° C. Part B was gradually added to part A and mixed uniformly.
実施例11 ヘアクリーム
下記処方のヘアクリームを調製した。このヘアクリームは、艶があり、べたつかず、毛髪の水分を保ち、つるつるとした感触を付与することができるものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
合成例2の化合物 0.50
セタノール 4.00
ジメチコン(500cs) 13.00
ステアリン酸グリセリル 2.80
オレス−10リン酸 0.80
ステアリン酸グリセリル(SE) 1.60
B部
フェノキシエタノール 0.40
メチルパラベン 0.20
10%NaOH 0.60
精製水 74.60
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部を約80℃に加温し、溶解させた。別容器にB部を加え、約80℃に加温し、溶解させた。A部にB部を加え撹拌混合した。
Example 11 Hair Cream A hair cream having the following formulation was prepared. This hair cream was glossy, non-sticky, kept the moisture of the hair, and was able to impart a smooth feel.
Component Blending amount (% by weight)
--------------------------------
Part A Compound of Synthesis Example 2 0.50
Cetanol 4.00
Dimethicone (500cs) 13.00
Glyceryl stearate 2.80
Ores-10 phosphate 0.80
Glyceryl stearate (SE) 1.60
Part B Phenoxyethanol 0.40
Methylparaben 0.20
10% NaOH 0.60
Purified water 74.60
--------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was added to a separate container, heated to about 80 ° C. and dissolved. Part B was added to part A and mixed with stirring.
実施例12 アンチエイジングクリーム
下記処方のアンチエイジングクリームを調製した。このクリームは、適度な粘度を示し、使用感に優れ、皮膚に潤いを与え皮膚の乾燥を防ぐものであり、これらの効果は長時間持続するものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
合成例2の化合物 1.00
エチルヘキサン酸セチル 7.00
イソステアリン酸バチル 2.00
イソステアリン酸PEG−60グリセリル 1.50
水添パーム油 3.70
レチノール 0.10
油溶性カミツレエキス 0.10
エチルパラベン 0.20
ステアリルアルコール 3.50
ステアリン酸グリセリル(SE) 1.00
ステアレス−6 1.50
ジステアリン酸PEG−8 1.00
セタノール 1.00
ジメチコン 1.00
セチルジメチコンコポリオール 0.50
トコフェロール 0.20
B部
西河柳エキス 0.05
C部
アルブチン 0.50
EDTA−3Na 0.10
ポリグルタミン酸(一丸ファルコス、バイオPGA溶液) 0.10
(エイコサン二酸/テトラデカン二酸)ポリグリセリル−10 1.00
グリセリン 4.00
亜硫酸水素Na 0.05
メチルパラベン 0.10
フェノキシエタノール 0.10
BG 6.00
水酸化K 適量
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(製造方法)
A部を約80℃に加温し、均一に溶解させた。C部を約80℃に加温し、溶解させた。約80℃でホモミキサーにて攪拌しながら、A部にC部を徐々に加え、乳化後均一に混合し、約40℃まで冷却し、B部を加え、均一に混合した。
Example 12 Anti-aging cream An anti-aging cream having the following formulation was prepared. This cream has an appropriate viscosity, is excellent in feeling of use, moisturizes the skin and prevents the skin from drying, and these effects last for a long time.
Component Blending amount (% by weight)
----------------------------------
Part A Compound of Synthesis Example 2 1.00
Cetyl ethylhexanoate 7.00
Batyl isostearate 2.00
PEG-60 glyceryl isostearate 1.50
Hydrogenated palm oil 3.70
Retinol 0.10
Oil-soluble chamomile extract 0.10
Ethylparaben 0.20
Stearyl alcohol 3.50
Glyceryl stearate (SE) 1.00
Steerless-6 1.50
Distearic acid PEG-8 1.00
Cetanol 1.00
Dimethicone 1.00
Cetyl dimethicone copolyol 0.50
Tocopherol 0.20
Part B Nishikawayanagi Extract 0.05
Part C Arbutin 0.50
EDTA-3Na 0.10
Polyglutamic acid (Ichimaru Falcos, Bio PGA solution) 0.10
(Eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
Glycerin 4.00
Bisulfite Na 0.05
Methylparaben 0.10
Phenoxyethanol 0.10
BG 6.00
Hydroxide K Appropriate amount Purified water Amount to be 100 in total ---------------------------------
(Production method)
Part A was heated to about 80 ° C. and dissolved uniformly. Part C was heated to about 80 ° C. and dissolved. While stirring with a homomixer at about 80 ° C., part C was gradually added to part A, mixed uniformly after emulsification, cooled to about 40 ° C., part B was added and mixed uniformly.
実施例13 化粧水
下記処方の保湿化粧水を調製した。この化粧水は、適度な粘度を示し、使用感に優れ、皮膚に潤いを与え皮膚の乾燥を防ぐものであり、これらの効果は長時間持続するものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
(エイコサン二酸/テトラデカン二酸)ポリグリセリル−10 1.00
BG 1.00
グリセリン 2.00
クエン酸 0.01
クエン酸Na 0.10
精製水 合計で100となる量
B部
合成例2の化合物 0.05
エチルヘキサン酸セチル 0.03
テトラオレイン酸ソルベス−60 0.12
ポリソルベート80 0.03
メチルパラベン 0.10
香料 微量
エタノール 7.00
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部を均一に溶解させた。次にB部を均一に溶解させた。B部にA部を攪拌しながら加え、均一にした。
Example 13 Lotion A moisturizing lotion having the following formulation was prepared. This skin lotion has an appropriate viscosity, is excellent in use feeling, moisturizes the skin and prevents the skin from drying, and these effects last for a long time.
Component Blending amount (% by weight)
--------------------------------
Part A (Eicosanedioic acid / Tetradecanedioic acid) Polyglyceryl-10 1.00
BG 1.00
Glycerin 2.00
Citric acid 0.01
Na citrate 0.10
Purified water Amount B totaling 100 parts Compound of Synthesis Example 2 0.05
Cetyl ethylhexanoate 0.03
Tetraoleic acid Solves-60 0.12
Polysorbate 80 0.03
Methylparaben 0.10
Fragrance Trace amount Ethanol 7.00
--------------------------------
(Preparation method)
Part A was dissolved uniformly. Next, part B was dissolved uniformly. A part was added to part B with stirring to make it uniform.
実施例14 シャンプー
下記処方のシャンプーを調製した。このシャンプーは、軋みを抑え、毛髪にしっとり感を付与し、なめらかな指通りを付与することができるものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
ココイルグルタミン酸TEA(30%) 50.00
テトラデセンスルホン酸Na(36%) 15.00
ジステアリン酸PEG−150 5.00
メチルパラベン 0.20
フェノキシエタノール 0.50
プロピレングリコール 1.00
合成例1の化合物 0.50
B部
カチオン化グアーガム 0.20
精製水 合計で100となる量
C部
リン酸(10%) 適量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部をそれぞれとり、約80℃に加温し、均一に混合した。B部にA部を加え、均一に混合した後、冷却した(D部)。D部にC部を加えpHを6〜6.5に調整した。
Example 14 Shampoo A shampoo having the following formulation was prepared. This shampoo was able to suppress itching, give the hair a moist feeling, and give smooth fingering.
Component Blending amount (% by weight)
--------------------------------
Part A Cocoyl glutamic acid TEA (30%) 50.00
Tetradecenesulfonic acid Na (36%) 15.00
Distearic acid PEG-150 5.00
Methylparaben 0.20
Phenoxyethanol 0.50
Propylene glycol 1.00
Compound of Synthesis Example 1 0.50
Part B Cationized guar gum 0.20
Purified water Amount to be 100 in total C part phosphoric acid (10%) appropriate amount -------------------------------
(Preparation method)
Part A and part B were taken and heated to about 80 ° C. and mixed uniformly. After adding A part to B part and mixing uniformly, it cooled (D part). C part was added to D part, and pH was adjusted to 6-6.5.
実施例15 トリートメント
下記処方のトリートメントを調製した。このトリートメントは、毛髪にしっとり感、柔軟感を付与することができるものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
合成例1の化合物 0.10
ベヘントリモニウムクロリド(80%) 2.40
セタノール 5.20
ステアリン酸グリセリル 1.20
LUSPLAN DA−R(日本精化) 0.40
ジメチコン 2.00
(アミノエチルアミノプロピルメチコン/ジメチコン)
コポリマー 0.50
B部
メチルパラベン 0.10
プロピルパラベン 0.10
精製水 合計で100となる量
C部
アデノシン一リン酸(10%) 適量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部をそれぞれとり、約80℃に加温し、均一に混合した。A部にB部を攪拌しながら徐々に加え、均一に混合した後、冷却した(D部)。D部にC部を加えpHを5.2〜5.7に調整した。
Example 15 Treatment A treatment having the following formulation was prepared. This treatment can impart a moist and soft feeling to the hair.
Component Blending amount (% by weight)
--------------------------------
Part A Compound of Synthesis Example 1 0.10
Behentrimonium chloride (80%) 2.40
Cetanol 5.20
Glyceryl stearate 1.20
LUSPLAN DA-R (Nippon Seika) 0.40
Dimethicone 2.00
(Aminoethylaminopropyl methicone / dimethicone)
Copolymer 0.50
Part B Methylparaben 0.10
Propylparaben 0.10
Purified water Total amount of 100 parts C Adenosine monophosphate (10%) Appropriate amount ------------------------------ −−
(Preparation method)
Part A and part B were taken and heated to about 80 ° C. and mixed uniformly. The part B was gradually added to the part A with stirring and mixed uniformly, and then cooled (part D). Part C was added to part D to adjust the pH to 5.2 to 5.7.
実施例16 洗い流さないヘアトリートメント
下記処方の洗い流さないヘアトリートメントを調製した。このヘアトリートメントは、毛髪のすべり、まとまり、指通り、しっとり感が向上するものであった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
合成例2の化合物 0.10
シクロヘキサンジカルボン酸ビスエトキシジグリコール 2.00
セトリモニウムクロリド(25%) 3.80
カプリリルグルコシド(50%) 0.80
グリセリン 4.00
フェノキシエタノール 0.20
B部
エタノール 20.00
C部
ポリクオタニウム−6 0.60
ポリクオタニウム−7 0.40
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
C部を約80℃に加温し、溶解させた。次にA部を約80℃に加温し溶解させた。C部を攪拌しながらA部加え、均一に混合後、約40℃まで冷却させた。次いで、B部を加え、均一に混合させた。
Example 16 Non-washing hair treatment A non-washing hair treatment of the following formulation was prepared. This hair treatment improved the slipperiness, unity, fingering and moistness of the hair.
Component Blending amount (% by weight)
--------------------------------
Part A Compound of Synthesis Example 2 0.10
Cyclohexanedicarboxylic acid bisethoxydiglycol 2.00
Cetrimonium chloride (25%) 3.80
Caprylyl glucoside (50%) 0.80
Glycerin 4.00
Phenoxyethanol 0.20
Part B Ethanol 20.00
Part C Polyquaternium-6 0.60
Polyquaternium-7 0.40
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part C was heated to about 80 ° C. and dissolved. Next, part A was heated to about 80 ° C. and dissolved. Part A was added with stirring, part A was mixed uniformly, and then cooled to about 40 ° C. Next, part B was added and mixed uniformly.
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KR101770440B1 (en) | 2009-12-28 | 2017-08-22 | 가부시키가이샤 시세이도 | Cosmetic preparation |
KR102273178B1 (en) * | 2020-08-28 | 2021-07-05 | 주식회사 비제이바이오켐 | Novel ceramide compound and preparation method thereof |
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JP6000540B2 (en) * | 2011-12-14 | 2016-09-28 | ポーラ化成工業株式会社 | Emulsified composition containing ceramide |
JP2014084308A (en) * | 2012-10-25 | 2014-05-12 | Fancl Corp | Liquid crystal composition |
JP7008971B2 (en) * | 2017-02-15 | 2022-01-25 | クラシエホームプロダクツ株式会社 | Cosmetics |
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US20200345611A1 (en) * | 2019-04-30 | 2020-11-05 | Evonik Operations Gmbh | Composition comprising at least one ceramide, at least one sphingoid base and triethyl citrate |
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FR2834986B1 (en) * | 2002-01-22 | 2004-02-20 | Oreal | NOVEL CERAMIDES, COMPOSITIONS CONTAINING THEM AND THEIR COSMETIC OR DERMATOLOGICAL USE |
JP4188149B2 (en) * | 2003-06-10 | 2008-11-26 | 花王株式会社 | Skin preparation |
JP4563194B2 (en) * | 2005-01-21 | 2010-10-13 | ポーラ化成工業株式会社 | Composition for external use |
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KR101770440B1 (en) | 2009-12-28 | 2017-08-22 | 가부시키가이샤 시세이도 | Cosmetic preparation |
KR102273178B1 (en) * | 2020-08-28 | 2021-07-05 | 주식회사 비제이바이오켐 | Novel ceramide compound and preparation method thereof |
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