JP2018087148A - COSMETIC CONTAINING γ-ORYZANOL - Google Patents
COSMETIC CONTAINING γ-ORYZANOL Download PDFInfo
- Publication number
- JP2018087148A JP2018087148A JP2016229783A JP2016229783A JP2018087148A JP 2018087148 A JP2018087148 A JP 2018087148A JP 2016229783 A JP2016229783 A JP 2016229783A JP 2016229783 A JP2016229783 A JP 2016229783A JP 2018087148 A JP2018087148 A JP 2018087148A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- extract
- oil
- oryzanol
- red
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 title claims abstract description 38
- 239000002537 cosmetic Substances 0.000 title claims description 45
- 239000000203 mixture Substances 0.000 claims abstract description 32
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 29
- 239000003960 organic solvent Substances 0.000 claims abstract description 26
- 238000002360 preparation method Methods 0.000 claims description 39
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 8
- 229940067606 lecithin Drugs 0.000 claims description 6
- 235000010445 lecithin Nutrition 0.000 claims description 6
- 239000000787 lecithin Substances 0.000 claims description 6
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 5
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Abstract
Description
本発明は、γ−オリザノールとリン脂質が有機溶媒中に均一に溶解している溶液から、有機溶媒を除去して、γ−オリザノールとリン脂質を同時に析出せしめて得られるγ−オリザノール−リン脂質複合体に関する。 The present invention relates to a γ-oryzanol-phospholipid obtained by removing an organic solvent from a solution in which γ-oryzanol and phospholipid are uniformly dissolved in an organic solvent, and simultaneously depositing γ-oryzanol and phospholipid. Concerning the complex.
γ−オリザノールは、古くから医薬品、食品、化粧品の有効成分として使用されている。γ−オリザノールの生体への作用は様々であり、皮膚への作用としては、例えば、抗酸化、紫外線吸収、血流促進、チロシナーゼ活性抑制、皮脂腺賦活等の作用が知られており、目的に応じて化粧品又は皮膚外用剤に配合されている。しかしながら、γ−オリザノールは難水溶性の化合物であり、これらを水系の処方に高濃度に配合するには、いったん油脂類などに溶解させたあと、界面活性剤を用いて水相中に乳化させる方法が用いられる(例えば特許文献1)。しかしながら、使用する界面活性剤の安全性や皮膚刺激性への懸念があり、これらの懸念のない処方が望まれていた。 γ-Oryzanol has long been used as an active ingredient in pharmaceuticals, foods and cosmetics. The action of γ-oryzanol on the living body is various, and as actions on the skin, for example, antioxidant, ultraviolet absorption, blood flow promotion, tyrosinase activity suppression, sebaceous gland activation, etc. are known, and depending on the purpose It is blended in cosmetics or skin external preparations. However, γ-oryzanol is a poorly water-soluble compound, and in order to incorporate these into a water-based formulation at a high concentration, it is first dissolved in fats and oils and then emulsified in an aqueous phase using a surfactant. A method is used (for example, Patent Document 1). However, there are concerns about the safety of the surfactants used and skin irritation, and a prescription without these concerns has been desired.
安全性、皮膚刺激性の懸念のない界面活性剤として、リン脂質が知られている。リン脂質は、生体の細胞膜を形成する主成分であり、人に対して非常に安全性が高く、また皮膚への刺激性もないため、医薬品、食品、化粧品等に広く用いられている。しかしながら、リン脂質は、油剤への溶解性が悪い、初期水和性が乏しい等の性質があり、リン脂質を用いた乳化又は可溶化組成物の調製には、特殊な装置を用いて激しく攪拌混合する等の煩雑な作業が必要となる。また、このような方法で得られる乳化又は可溶化組成物の分散安定性は十分とは言えなかった。 Phospholipids are known as surfactants that do not have safety and skin irritation concerns. Phospholipids are the main components that form biological cell membranes, are extremely safe for humans, and are not irritating to the skin. Therefore, phospholipids are widely used in pharmaceuticals, foods, cosmetics, and the like. However, phospholipids have properties such as poor solubility in oils and poor initial hydration properties. For the preparation of emulsified or solubilized compositions using phospholipids, vigorous stirring is performed using a special apparatus. Complicated work such as mixing is required. Moreover, it cannot be said that the dispersion stability of the emulsified or solubilized composition obtained by such a method is sufficient.
特許文献2には、難水溶性の生理活性物質とリン脂質が有機溶媒中に均一に溶解している溶液から、有機溶媒を除去して、難水溶性の生理活性物質とリン脂質を同時に析出せしめて得られる難水溶性生理活性物質−リン脂質複合体が開示されており、該複合体を用いることでリン脂質を用いて難水溶性の生理活性物質を簡便に乳化又は可溶化でき、得られる組成物の分散安定性も良好であることが記載されている。また特許文献2においては、γ−オリザノール10重量%とリン脂質90重量%からなる複合体(製造例3)が開示され、この複合体を0.2重量%の濃度で配合した水分散液(実施例3、γ−オリザノールの濃度として0.02重量%)が開示され、この分散液が安定性に優れることが開示されている(表1、表2)。しかしながら、γ−オリザノールの効果・効能をより発揮させるため、水系の処方にγ−オリザノールをより高濃度に配合することが望まれている。 In Patent Document 2, the organic solvent is removed from the solution in which the poorly water-soluble physiologically active substance and phospholipid are uniformly dissolved in the organic solvent, and the poorly water-soluble physiologically active substance and phospholipid are simultaneously deposited. A sparingly water-soluble physiologically active substance-phospholipid complex obtained is disclosed, and by using the complex, a sparingly water-soluble physiologically active substance can be easily emulsified or solubilized using phospholipid. It is described that the dispersion stability of the resulting composition is also good. Patent Document 2 discloses a complex (Production Example 3) composed of 10% by weight of γ-oryzanol and 90% by weight of phospholipid, and an aqueous dispersion containing this complex at a concentration of 0.2% by weight ( Example 3, 0.02% by weight as the concentration of γ-oryzanol) is disclosed, and it is disclosed that this dispersion is excellent in stability (Tables 1 and 2). However, in order to further exhibit the effects and efficacy of γ-oryzanol, it is desired to add γ-oryzanol to an aqueous formulation at a higher concentration.
本発明者らは、リン脂質を用いてγ−オリザノールを高濃度に配合した乳化又は可溶化組成物を作製することを目的に、特許文献2の複合体(製造例3)を使用して種々検討したところ、γ−オリザノールを高濃度に配合するべく、乳化又は可溶化組成物への複合体の配合量を多くすると、得られる乳化又は可溶化組成物の外観に透明性がなくなり、かつ、分散安定性が不十分となることを見出した。したがって本発明の課題は、γ−オリザノールを簡便かつ高濃度に乳化又は可溶化させることができ、かつ、外観に透明感があり、分散安定性が良好な乳化又は可溶化組成物が得られる複合体を提供することにある。 The inventors of the present invention use various composites (Production Example 3) of Patent Document 2 for the purpose of preparing an emulsified or solubilized composition containing γ-oryzanol at a high concentration using phospholipids. When examined, increasing the blending amount of the complex to the emulsified or solubilized composition in order to blend γ-oryzanol at a high concentration, the transparency of the resulting emulsified or solubilized composition is lost, and It was found that the dispersion stability was insufficient. Accordingly, an object of the present invention is to provide a composite in which γ-oryzanol can be easily emulsified or solubilized at a high concentration, and an emulsified or solubilized composition having a transparent appearance and good dispersion stability can be obtained. To provide a body.
本発明者らは上記課題を解決すべく鋭意検討を行った結果、成分(A)γ−オリザノールと、成分(B)リン脂質が有機溶媒中に均一に溶解している溶液から、有機溶媒を除去して、γ−オリザノールとリン脂質を同時に析出せしめて得られるγ−オリザノール−リン脂質複合体で、成分(A)の含有量が20〜40%、成分(B)の含有量が60〜80%であることを特徴とする複合体を用いることにより、上記課題を解決することを見出し、本発明を完成させた。 As a result of intensive studies to solve the above problems, the present inventors have determined that an organic solvent is removed from a solution in which the component (A) γ-oryzanol and the component (B) phospholipid are uniformly dissolved in the organic solvent. The γ-oryzanol-phospholipid complex obtained by removing and simultaneously depositing γ-oryzanol and phospholipid, the content of component (A) is 20-40%, the content of component (B) is 60- It was found that the above-mentioned problems can be solved by using a composite characterized by 80%, and the present invention was completed.
本発明の複合体を用いることにより、水中にγ−オリザノールを簡便かつ高濃度に乳化又は可溶化させることができる。また、得られる乳化又は可溶化組成物は外観に透明感があり、その分散安定性は良好である。 By using the complex of the present invention, γ-oryzanol can be easily emulsified or solubilized in water at a high concentration. Moreover, the emulsified or solubilized composition obtained has a transparent appearance and its dispersion stability is good.
本発明でいう複合体とは、複数の物質の混合物が単体個々の化学的性質を維持しつつ、複合体としてひとつの物理化学的性質を示すものをいう。例えば、複合化により温度に対する挙動が変化したり、溶媒に対する溶解性や分散性が変化することが挙げられる。 The composite as used in the present invention refers to a composite that exhibits one physicochemical property as a composite while a mixture of a plurality of substances maintains individual chemical properties. For example, the behavior with respect to temperature changes due to the composite, and the solubility and dispersibility in a solvent change.
本発明の複合体は、γ−オリザノールとリン脂質が有機溶媒中に均一に溶解している溶液から、有機溶媒を除去して、γ−オリザノールとリン脂質を同時に析出させることにより得られる。 The complex of the present invention can be obtained by removing the organic solvent from a solution in which γ-oryzanol and phospholipid are uniformly dissolved in the organic solvent, and simultaneously depositing γ-oryzanol and phospholipid.
本発明の複合体の製造方法は以下の通りである。まずγ−オリザノールとリン脂質を有機溶媒に均一に溶解又は分散させる。このとき、加温、攪拌等の手段を用いると効率よく行うことができる。次に、上記有機溶媒溶液から有機溶媒を除去して、γ−オリザノールとリン脂質を同時に析出させる。この方法としては、例えば、上記有機溶媒溶液を加温又は/及び減圧下で有機溶媒を留去する方法や、上記有機溶媒溶液を噴霧乾燥する方法、上記有機溶媒を液体窒素等により瞬時に凍結後、凍結乾燥する方法等が挙げられる。このような方法により目的の複合体を半固体、固体、粉末の状態で得ることができるが、水に分散させる際の膨潤速度の観点から粉末状で得ることが好ましい。このことより、製造方法としては噴霧乾燥及び凍結乾燥を用いることが好ましく、さらに噴霧乾燥として、上記有機溶媒溶液を管状加熱器に一定速度で供給し、該加熱器内で加温して有機溶媒を蒸発させて実質的に固形分と有機溶媒の蒸気との混合物とし、この混合物を高速で真空室に導入し、瞬間的に有機溶媒を揮散させる装置(瞬間真空乾燥機)を用いることが最も好ましい。本装置の詳細については特許文献3に記載がある。 The method for producing the composite of the present invention is as follows. First, γ-oryzanol and phospholipid are uniformly dissolved or dispersed in an organic solvent. At this time, it can be carried out efficiently by using means such as heating and stirring. Next, the organic solvent is removed from the organic solvent solution to precipitate γ-oryzanol and phospholipid simultaneously. As this method, for example, the organic solvent solution is heated or / and the organic solvent is distilled off under reduced pressure, the organic solvent solution is spray-dried, or the organic solvent is instantly frozen with liquid nitrogen or the like. Thereafter, a method of freeze-drying and the like can be mentioned. Although the target complex can be obtained in a semi-solid, solid, or powder state by such a method, it is preferably obtained in a powder form from the viewpoint of the swelling speed when dispersed in water. From this, it is preferable to use spray drying and freeze drying as the production method. Further, as the spray drying, the organic solvent solution is supplied to the tubular heater at a constant rate, and the organic solvent is heated in the heater. It is most preferable to use a device that instantaneously evaporates the organic solvent (instantaneous vacuum dryer) by evaporating the mixture into a mixture of substantially solids and vapor of the organic solvent, and introducing the mixture into the vacuum chamber at high speed. preferable. Details of this apparatus are described in Patent Document 3.
本発明の複合体の製造に用いられる有機溶媒としては、複合化させる全成分を均一に溶解または分散させるものであれば特に制限はなく、例えば、ペンタン、ヘキサン、ヘプタン、シクロヘキサン等の炭化水素類;塩化メチレン、クロロホルム等のハロゲン化炭化水素類;ベンゼン、トルエン等の芳香族炭化水素類;メタノール、エタノール、イソプロパノール、t−ブチルアルコール等の低級アルコール類;酢酸メチル、酢酸エチル等のエステル類が挙げられる。これらの有機溶媒は単独で用いてもよいし、あるいは2種類以上を混合して使用してもよい。これらのうち、溶解性及び安全性等の観点から、ペンタン、ヘキサン、ヘプタン、シクロヘキサン等の炭化水素類、メタノール、エタノール、イソプロパノール、t−ブチルアルコール等の低級アルコール類が好ましいものとして挙げられる。 The organic solvent used in the production of the composite of the present invention is not particularly limited as long as it can uniformly dissolve or disperse all components to be complexed. For example, hydrocarbons such as pentane, hexane, heptane, and cyclohexane Halogenated hydrocarbons such as methylene chloride and chloroform; aromatic hydrocarbons such as benzene and toluene; lower alcohols such as methanol, ethanol, isopropanol and t-butyl alcohol; esters such as methyl acetate and ethyl acetate; Can be mentioned. These organic solvents may be used alone or in combination of two or more. Of these, hydrocarbons such as pentane, hexane, heptane, and cyclohexane, and lower alcohols such as methanol, ethanol, isopropanol, and t-butyl alcohol are preferable from the viewpoints of solubility and safety.
本発明の複合体の製造に用いられる有機溶媒の使用量は、複合化させる全成分が均一に溶解又は分散していればよく、特に制限はないが、複合化させる成分の溶解性に応じて使用量を適宜変化させることができる。一般的には複合化させる全成分に対して1〜100重量倍、好ましくは3〜50重量倍使用するとよい。 The amount of the organic solvent used in the production of the complex of the present invention is not particularly limited as long as all components to be complexed are uniformly dissolved or dispersed, but depending on the solubility of the component to be complexed The amount used can be changed as appropriate. In general, it is preferable to use 1 to 100 times by weight, preferably 3 to 50 times by weight, based on all components to be combined.
本発明で使用される成分(A)γ−オリザノールは、自然界において米やトウモロコシ等の穀類に存在する物質で、複数種のトリテルペンアルコール又はステロールとフェルラ酸がエステル結合した化合物の混合物である。工業的には米糠や米胚芽から抽出して得ることができ、例えば、築野食品工業株式会社やオリザ油化株式会社から市販されている。本発明ではこのような市販品を使用することができ、また、その他の由来から得られるものを使用してもよく、その製造方法や精製方法等に特に制限はない。 Component (A) γ-oryzanol used in the present invention is a substance that naturally exists in cereals such as rice and corn, and is a mixture of a plurality of types of triterpene alcohol or a compound in which sterol and ferulic acid are ester-bonded. Industrially, it can be obtained by extracting from rice bran or rice germ, and is commercially available from, for example, Tsukino Food Industry Co., Ltd. or Oriza Oil Chemical Co., Ltd. In this invention, such a commercial item can be used, and what is obtained from another origin may be used, and there is no restriction | limiting in particular in the manufacturing method, the refinement | purification method, etc.
本発明で使用される成分(B)リン脂質としては、ホスファチジルエタノールアミン、ホスファチジルイノシトール、ホスファチジルセリン、ホスファチジン酸等の極性基を有するジアシルグリセロリン脂質;大豆、なたね、ひまわり、サフラワー、落花生、綿実、トウモロコシ、米、大麦などの植物や卵黄から得られる天然レシチン及びこれらの水素添加物が例示できる。さらにこれらはポリエチレングリコール等のポリオキシアルキレン基で修飾された誘導体であっても良い。これらのリン脂質は単独で用いてもよいし、2種類以上を混合して用いてもよい。これらのうち、入手性や本発明の効果を発揮させる観点から、天然レシチン及びこれらの水素添加物が好ましいものとして挙げられる。さらに天然のレシチンとしては、その精製度合いによりホスファチジルコリン(以下、PC)の含量が異なるものが市販されているが、本発明にはPC含有量が50〜90重量%ものを使用するのが好ましく、より好ましくは60〜90重量%である。 As the component (B) phospholipid used in the present invention, diacylglycerophospholipid having a polar group such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidic acid; soybean, rapeseed, sunflower, safflower, peanut, cotton Examples thereof include natural lecithin obtained from plants such as corn, rice and barley and egg yolk, and hydrogenated products thereof. Furthermore, these may be derivatives modified with a polyoxyalkylene group such as polyethylene glycol. These phospholipids may be used alone or in combination of two or more. Among these, natural lecithin and hydrogenated products thereof are preferable from the viewpoint of obtaining availability and the effects of the present invention. Furthermore, as natural lecithin, those having different contents of phosphatidylcholine (hereinafter, PC) depending on the degree of purification are commercially available, but it is preferable to use those having a PC content of 50 to 90% by weight in the present invention, More preferably, it is 60 to 90% by weight.
本発明の複合体は、前述の成分(A)γ−オリザノールと成分(B)リン脂質からなり、成分(A)の含有量が20〜40重量%、成分(B)の含有量が60〜80重量%であることを特徴とする。また、より好ましくは、成分(A)の含有量が30〜40重量%、成分(B)の含有量が60〜70%重量である。このようにして得られる複合体を用いることで、γ−オリザノールを簡便かつ高濃度に乳化又は可溶化させることができる。本発明において高濃度とは、乳化又は可溶化組成物中にγ−オリザノールが、0.05重量%以上、より好ましくは0.1重量%以上配合されていることを意味する。
また、本発明の複合体を使用して得られる乳化又は可溶化組成物は外観に透明感があり、その分散安定性は良好である。本発明において外観に透明感があるとは、直径3.5cmのガラス瓶に試料を入れて横から観察した際に、液の背後が透けて見える程度の透明感を言う。分光光度計にて濁度を測定する場合、厚さ1cmのセルに試料を入れて、波長600nmで測定した際の透過率が20%以上である。
複合体中の成分(A)の含有量が20重量%より少ないと、γ−オリザノールを高濃度に配合した場合、得られる乳化又は可溶化組成物の外観に透明感がなくなり、かつ、分散安定性も悪くなる。逆に成分(A)の含有量が40重量%より多いと、γ−オリザノールが水中に分散できなくなってしまう。
The complex of the present invention comprises the aforementioned component (A) γ-oryzanol and component (B) phospholipid, the content of component (A) is 20 to 40% by weight, and the content of component (B) is 60 to 80% by weight. More preferably, the content of the component (A) is 30 to 40% by weight, and the content of the component (B) is 60 to 70% by weight. By using the complex thus obtained, γ-oryzanol can be easily emulsified or solubilized at a high concentration. In the present invention, high concentration means that γ-oryzanol is mixed in an emulsified or solubilized composition in an amount of 0.05% by weight or more, more preferably 0.1% by weight or more.
In addition, the emulsified or solubilized composition obtained using the composite of the present invention has a transparent appearance and good dispersion stability. In the present invention, “transparency” means that the appearance of the liquid is transparent when the sample is placed in a glass bottle having a diameter of 3.5 cm and observed from the side. When measuring turbidity with a spectrophotometer, the transmittance is 20% or more when a sample is put in a cell having a thickness of 1 cm and measured at a wavelength of 600 nm.
When the content of the component (A) in the composite is less than 20% by weight, when γ-oryzanol is blended at a high concentration, the appearance of the resulting emulsified or solubilized composition is not transparent, and the dispersion is stable. Also worse. Conversely, if the content of component (A) is more than 40% by weight, γ-oryzanol cannot be dispersed in water.
本発明の複合体を含有する化粧料には、必要に応じて水及び通常化粧料に配合される添加成分、例えば油性基剤、界面活性剤、アルコール類、保湿剤、高分子・増粘・ゲル化剤、酸化防止剤、防腐剤、殺菌剤、キレート剤、pH調整剤・酸・アルカリ、紫外線吸収剤、美白剤、溶剤、角質剥離・溶解剤、鎮痒剤、消炎剤、制汗剤、清涼剤、抗ヒスタミン剤、収れん剤、刺激剤、育毛用薬剤・血行促進剤、還元剤・酸化剤、高分子粉体、ヒドロキシ酸、ビタミン類及びその誘導体類、糖類及びその誘導体類、有機酸類、酵素類、核酸類、ホルモン類、無機粉体類、香料、色素等を本発明の効果を損なわない程度で含有していてもよい。 Cosmetics containing the composite of the present invention include water and additives added to normal cosmetics as necessary, such as oil bases, surfactants, alcohols, humectants, polymers, thickeners, Gelling agent, antioxidant, antiseptic, bactericidal agent, chelating agent, pH adjuster / acid / alkali, UV absorber, whitening agent, solvent, exfoliating / dissolving agent, antipruritic agent, anti-inflammatory agent, antiperspirant, Refreshing agents, antihistamines, astringents, stimulants, hair growth agents / blood circulation promoters, reducing agents / oxidants, polymer powders, hydroxy acids, vitamins and derivatives thereof, saccharides and derivatives thereof, organic acids, enzymes , Nucleic acids, hormones, inorganic powders, fragrances, pigments and the like may be contained to the extent that the effects of the present invention are not impaired.
油性基剤としては、セタノール、ミリスチルアルコール、オレイルアルコール、ラウリルアルコール、セトステアリルアルコール、ステアリルアルコール、アラキルアルコール、ベヘニルアルコール、ホホバアルコール、キミルアルコール、セラキルアルコール、バチルアルコール、ヘキシルデカノール、イソステアリルアルコール、2−オクチルドデカノール、ダイマージオール等の高級アルコール類;ベンジルアルコール等のアラルキルアルコール及び誘導体;ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、イソステアリン酸、ベヘン酸、ウンデシレン酸、12−ヒドロキシステアリン酸、パルミトオレイン酸、オレイン酸、リノール酸、リノレイン酸、エルカ酸、ドコサヘキサエン酸、エイコサペンタエン酸、イソヘキサデカン酸、アンテイソヘンイコサン酸、長鎖分岐脂肪酸、ダイマー酸、水素添加ダイマー酸等の高級脂肪酸類及びそのアルミニウム塩、カルシウム塩、マグネシウム塩、亜鉛塩、カリウム、ナトリウム塩等の金属石けん類、及びアミド等の含窒素誘導体類;流動パラフィン(ミネラルオイル)、重質流動イソパラフィン、軽質流動イソパラフィン、α−オレフィンオリゴマー、ポリイソブテン、水添ポリイソブテン、ポリブテン、スクワラン、オリーブ由来スクワラン、スクワレン、ワセリン、固形パラフィン等の炭化水素類;キャンデリラワックス、カルナウバワックス、ライスワックス、木ろう、みつろう、モンタンワックス、オゾケライト、セレシン、パラフィンワックス、マイクロクリスタリンワックス、ペトロラタム、フィッシャートロプシュワックス、ポリエチレンワックス、エチレン・プロピレンコポリマー等のワックス類;ヤシ油、パーム油、パーム核油、サフラワー油、オリーブ油、ヒマシ油、アボカド油、ゴマ油、茶油、月見草油、小麦胚芽油、マカデミアナッツ油、ヘーゼルナッツ油、ククイナッツ油、ローズヒップ油、メドウフォーム油、パーシック油、ティートリー油、ハッカ油、トウモロコシ油、ナタネ油、ヒマワリ油、小麦胚芽油、アマニ油、綿実油、大豆油、落花生油、コメヌカ油、カカオ脂、シア脂、水素添加ヤシ油、水素添加ヒマシ油、ホホバ油、水素添加ホホバ油等の植物油脂類;牛脂、乳脂、馬脂、卵黄油、ミンク油、タートル油等の動物性油脂類;鯨ロウ、ラノリン、オレンジラッフィー油等の動物性ロウ類;液状ラノリン、還元ラノリン、吸着精製ラノリン、酢酸ラノリン、酢酸液状ラノリン、ヒドロキシラノリン、ポリオキシエチレンラノリン、ラノリン脂肪酸、硬質ラノリン脂肪酸、ラノリンアルコール、酢酸ラノリンアルコール、酢酸(セチル・ラノリル)エステル等のラノリン類;レシチン、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、ホスファチジルグリセロール、ホスファチジルイノシトール、スフィンゴミエリン等のスフィンゴリン脂質、ホスファチジン酸、環状リゾホスファチジン酸またはその塩、リゾレシチン等のリン脂質類;水素添加大豆リン脂質、部分水素添加大豆リン脂質、水素添加卵黄リン脂質、部分水素添加卵黄リン脂質等のリン脂質誘導体類;コレステロール、ジヒドロコレステロール、ラノステロール、ジヒドロラノステロール、フィトステロール、コール酸等のステロール類;サポゲニン類;サポニン類;酢酸コレステリル、ノナン酸コレステリル、ステアリン酸コレステリル、イソステアリン酸コレステリル、オレイン酸コレステリル、N−ラウロイル−L−グルタミン酸ジ(コレステリル/ベヘニル/オクチルドデシル)、N−ラウロイル−L−グルタミン酸ジ(コレステリル/オクチルドデシル)、N−ラウロイル−L−グルタミン酸ジ(フィトステリル/ベヘニル/オクチルドデシル)、N−ラウロイル−L−グルタミン酸ジ(フィトステリル/オクチルドデシル)、N−ラウロイルサルコシンイソプロピル等のアシルサルコシンアルキルエステル、12−ヒドロキシステアリン酸コレステリル、マカデミアナッツ油脂肪酸コレステリル、マカデミアナッツ油脂肪酸フィトステリル、ヒマワリ種子油脂肪酸フィトステリル、イソステアリン酸フィトステリル、軟質ラノリン脂肪酸コレステリル、硬質ラノリン脂肪酸コレステリル、長鎖分岐脂肪酸コレステリル、長鎖α−ヒドロキシ脂肪酸コレステリル等のステロールエステル類;リン脂質・コレステロール複合体、リン脂質・フィトステロール複合体等の脂質複合体;ミリスチン酸オクチルドデシル、ミリスチン酸ヘキシルデシル、イソステアリン酸オクチルドデシル、パリミチン酸セチル、パルミチン酸オクチルドデシル、オクタン酸セチル、オクタン酸ヘキシルデシル、イソノナン酸イソトリデシル、イソノナン酸イソノニル、イソノナン酸オクチル、イソノナン酸イソトリデシル、ネオペンタン酸イソデシル、ネオペンタン酸イソトリデシル、ネオペンタン酸イソステアリル、ネオデカン酸オクチルドデシル、オレイン酸オレイル、オレイン酸オクチルドデシル、リシノレイン酸オクチルドデシル、ラノリン脂肪酸オクチルドデシル、炭酸ジカプリリル、ジメチルオクタン酸ヘキシルデシル、エルカ酸オクチルドデシル、イソステアリン酸硬化ヒマシ油、オレイン酸エチル、アボカド油脂肪酸エチル、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、パルミチン酸オクチル、イソステアリン酸イソプロピル、ラノリン脂肪酸イソプロピル、ラウリン酸メチルヘプチル、ミリスチン酸メチルヘプチル、パルミチン酸メチルヘプチル、イソステアリン酸メチルヘプチル、セバシン酸ジエチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、アジピン酸ジイソプロピル、セバシン酸ジブチルオクチル、アジピン酸ジイソブチル、コハク酸ジオクチル、クエン酸トリエチル等のモノアルコールカルボン酸エステル類;乳酸セチル、リンゴ酸ジイソステアリル、モノイソステアリン酸水添ヒマシ油、γ−エルカラクトン等のオキシ酸エステル類;トリオクタン酸グリセリル、トリオレイン酸グリセリル、トリイソステアリン酸グリセリル、ジイソステアリン酸グリセリル、トリ(カプリル酸/カプリン酸)グリセリル、トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリル、水添ロジントリグリセリド(水素添加エステルガム)、ロジントリグリセリド(エステルガム)、ベヘン酸エイコサン二酸グリセリル、トリオクタン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、ジオクタン酸ネオペンチルグリコール、ジカプリン酸ネオペンチルグリコール、ジオクタン酸2−ブチル−2−エチル−1,3−プロパンジオール、ジオレイン酸プロピレングリコール、テトラオクタン酸ペンタエリスリチル、水素添加ロジンペンタエリスリチル、トリエチルヘキサン酸ジトリメチロールプロパン、(イソステアリン酸/セバシン酸)ジトリメチロールプロパン、トリエチルヘキサン酸ペンタエリスリチル、(ヒドロキシステアリン酸/ステアリン酸/ロジン酸)ジペンタエリスリチル、ジイソステアリン酸ジグリセリル、テトライソステアリン酸ポリグリセリル、ノナイソステアリン酸ポリグリセリル−10、デカ(エルカ酸/イソステアリン酸/リシノレイン酸)ポリグリセリル−8、(ヘキシルデカン酸/セバシン酸)ジグリセリルオリゴエステル、ジステアリン酸グリコール(ジステアリン酸エチレングリコール)、ジネオペンタン酸3−メチル−1,5−ペンタンジオール、ジネオペンタン酸2,4−ジエチル−1,5−ペンタンジオール等の多価アルコール脂肪酸エステル類;ジカプリリルエーテル等のアルキルエーテル類;ダイマージリノール酸ジイソプロピル、ダイマージリノール酸ジイソステアリル、ダイマージリノール酸ジ(イソステアリル/フィトステリル)、ダイマージリノール酸(フィトステリル/ベヘニル)、ダイマージリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)、ダイマージリノール酸ダイマージリノレイル、ジイソステアリン酸ダイマージリノレイル、ダイマージリノレイル水添ロジン縮合物、ダイマージリノール酸硬化ヒマシ油、ヒドロキシアルキルダイマージリノレイルエーテル等のダイマー酸若しくはダイマージオールの誘導体;ヤシ油脂肪酸モノエタノールアミド(コカミドMEA)、ヤシ油脂肪酸ジエタノールアミド(コカミドDEA)、ラウリン酸モノエタノールアミド(ラウラミドMEA)、ラウリン酸ジエタノールアミド(ラウラミドDEA)、ラウリン酸モノイソプロパノールアミド(ラウラミドMIPA)、パルミチン酸モノエタノールアミド(パルタミドMEA)、パルミチン酸ジエタノールアミド(パルタミドDEA)、ヤシ油脂肪酸メチルエタノールアミド(コカミドメチルMEA)等の脂肪酸アルカノールアミド類;ジメチコン(ジメチルポリシロキサン)、高重合ジメチコン(高重合ジメチルポリシロキサン)、シクロメチコン(環状ジメチルシロキサン、デカメチルシクロペンタシロキサン)、フェニルトリメチコン、ジフェニルジメチコン、フェニルジメチコン、(アミノエチルアミノプロピルメチコン/ジメチコン)コポリマー、ジメチコノール、ジメチコノールクロスポリマー、シリコーン樹脂、シリコーンゴム、アミノプロピルジメチコン及びアモジメチコン等のアミノ変性シリコーン、カチオン変性シリコーン、ジメチコンコポリオール等のポリエーテル変性シリコーン、ポリグリセリン変性シリコーン、糖変性シリコーン、カルボン酸変性シリコーン、リン酸変性シリコーン、硫酸変性シリコーン、アルキル変性シリコーン、脂肪酸変性シリコーン、アルキルエーテル変性シリコーン、アミノ酸変性シリコーン、ペプチド変性シリコーン、フッ素変性シリコーン、カチオン変性及びポリエーテル変性シリコーン、アミノ変性及びポリエーテル変性シリコーン、アルキル変性及びポリエーテル変性シリコーン、アミドアルキル変性シリコーン、アミノグリコール変性シリコーン、アミノフェニル変性シリコーン、ポリシロキサン・オキシアルキレン共重合体等のシリコーン類;パーフルオロデカン、パーフルオロオクタン、パーフルオロポリエーテル等のフッ素系油剤類が、好ましいものとして挙げられる。 Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as cannic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Hydrocarbons such as paraffin; candelilla wax, carnauba wax, rice wax, wax wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Tropsch wax, polyethylene wax, waxes such as ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cacao butter, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Fats and oils; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof, phospholipids such as lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospho Phospholipid derivatives such as lipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanostero , Sterols such as dihydrolanosterol, phytosterol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamate di (cholesteryl / behenyl) / Octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl) ), Acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid choles Steryl esters such as teryl, macadamia nut oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipids / cholesterol Complexes, lipid complexes such as phospholipid / phytosterol complexes; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl parimilate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isononanoic acid Isotridecyl, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, ne Isotridecyl pentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid cure Castor oil, ethyl oleate, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, methyl heptyl laurate, methyl heptyl palmitate, methyl heptyl palmitate, methyl isostearate Heptyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, Monoalcohol carboxylic acid esters such as diisopropyl pinate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate; cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, γ-ercalactone Oxyesters such as: glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic acid / capric acid), tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl , Hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, triisostearate Trimethylol propane acid, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin Pentaerythrityl, triethylhexanoic acid ditrimethylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, triethylhexanoic acid pentaerythrityl, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diisostearate diglyceryl, tetraisostearic acid Polyglyceryl, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, ( Hexyl decanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate, etc. Polyhydric alcohol fatty acid esters; alkyl ethers such as dicaprylyl ether; diisopropyl dimerolinolate diisostearyl, dimerdilinoleate diisostearyl, dimerdilinoleate di (isostearyl / phytosteryl), dimerdilinoleic acid (phytosteryl / behenyl) ), Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearic dimer dilinoleyl, die -Dimerinoyl hydrogenated rosin condensate, dimer linoleic acid hydrogenated castor oil, dimer acid or dimer diol derivative such as hydroxyalkyl dimer linoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide) DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA) , Fatty acid alkanolamides such as coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), high polymerization Methicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, Silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, polyether-modified silicone such as cation-modified silicone and dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone , Sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino Non-acid modified silicone, peptide modified silicone, fluorine modified silicone, cation modified and polyether modified silicone, amino modified and polyether modified silicone, alkyl modified and polyether modified silicone, amide alkyl modified silicone, amino glycol modified silicone, aminophenyl modified Preferable examples include silicones such as silicone and polysiloxane / oxyalkylene copolymer; and fluorine-based oils such as perfluorodecane, perfluorooctane and perfluoropolyether.
保湿剤・感触向上剤としては、グリセリン、1,3−ブチレングリコール、プロピレングリコール、3−メチル−1,3−ブタンジオール、1,3−プロパンジオール、2−メチル−1,3−プロパンジオール、トリメチロールプロパン、ペンタエリスリトール、ヘキシレングリコール、ジグリセリン、ポリグリセリン、ジエチレングリコール、ポリエチレングリコール、ジプロピレングリコール、ポリプロピレングリコール、エチレングリコール・プロピレングリコール共重合体等のポリオール類及びその重合体;ジエチレングリコールモノエチルエーテル(エトキシジグリコール)、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、ジエチレングリコールジブチルエーテル等のグリコールアルキルエーテル類;(エイコサン二酸/テトラデカン二酸)ポリグリセリル−10、テトラデカン二酸ポリグリセリル−10、シクロヘキサンジカルボン酸ビスエトキシジグリコール等の水溶性エステル類;ソルビトール、キシリトール、エリスリトール、マンニトール、マルチトール等の糖アルコール類;グルコース、フルクトース、ガラクトース、マンノース、トレオース、キシロース、アラビノース、フコース、リボース、デオキシリボース、マルトース、トレハロース、ラクトース、ラフィノース、グルコン酸、グルクロン酸、シクロデキストリン類(α−、β−、γ−シクロデキストリン、及び、マルトシル化、ヒドロキシアルキル化等の修飾シクロデキストリン)、β−グルカン、キチン、キトサン、ヘパリン及び誘導体、ペクチン、アラビノガラクタン、デキストリン、デキストラン、グリコーゲン、エチルグルコシド、メタクリル酸グルコシルエチル重合物若しくは共重合物等の糖類及びその誘導体類;ヒアルロン酸、ヒアルロン酸ナトリウム;コンドロイチン硫酸ナトリウム;ムコイチン硫酸、カロニン硫酸、ケラト硫酸、デルマタン硫酸;シロキクラゲ抽出物、シロキクラゲ多糖体;イヌリン、レバン等のフルクタン類;フコイダン;チューベロース多糖体、天然由来多糖体;クエン酸、酒石酸、乳酸等の有機酸及びその塩;尿素;2−ピロリドン−5−カルボン酸及びそのナトリウム等の塩;ベタイン(トリメチルグリシン)、プロリン、ヒドロキシプロリン、アルギニン、リジン、セリン、グリシン、アラニン、フェニルアラニン、チロシン、β−アラニン、スレオニン、グルタミン酸、グルタミン、アスパラギン、アスパラギン酸、システイン、シスチン、メチオニン、ロイシン、イソロイシン、バリン、トリプトファン、ヒスチジン、タウリン等のアミノ酸類及びその塩;コラーゲン、魚由来コラーゲン、アテロコラーゲン、ゼラチン、エラスチン、コラーゲン分解ペプチド、加水分解コラーゲン、塩化ヒドロキシプロピルアンモニウム加水分解コラーゲン、エラスチン分解ペプチド、ケラチン分解ペプチド、加水分解ケラチン、コンキオリン分解ペプチド、加水分解コンキオリン、シルク蛋白分解ペプチド、加水分解シルク、ラウロイル加水分解シルクナトリウム、大豆蛋白分解ペプチド、小麦蛋白分解ペプチド、加水分解小麦蛋白、カゼイン分解ペプチド、アシル化ペプチド等の蛋白ペプチド類及びその誘導体;パルミトイルオリゴペプチド、パルミトイルペンタペプチド、パルミトイルテトラペプチド等のアシル化ペプチド類;シリル化ペプチド類;乳酸菌培養液、酵母抽出液、卵殻膜タンパク、牛顎下腺ムチン、ヒポタウリン、ゴマリグナン配糖体、グルタチオン、アルブミン、乳清;塩化コリン、ホスホリルコリン;胎盤抽出液、エアラスチン、コラーゲン、アロエ抽出物、ハマメリス水、ヘチマ水、カモミラエキス、カンゾウエキス、コンフリーエキス、シルクエキス、イザヨイバラエキス、セイヨウノコギリソウエキス、ユーカリエキス、メリロートエキス等の動物・植物抽出成分、天然型セラミド(タイプ1、2、3、4、5、6)、ヒドロキシセラミド、疑似セラミド、スフィンゴ糖脂質、セラミド及び糖セラミド含有エキス等のセラミド類が好ましいものとして挙げられる。 As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosane diacid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan Sulfuric acid; white jellyfish extract; white jellyfish polysaccharide; fructans such as inulin and levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; organic acids such as citric acid, tartaric acid and lactic acid and salts thereof; urea; 2-pyrrolidone-5 -Carboxylic acid and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine Amino acids and salts thereof such as glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagenolytic peptide, Hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic Peptides, wheat proteolytic peptides, hydrolyzed wheat proteins, casein degrading peptides, acylated peptides and other protein peptides and their Derivatives; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, Glutathione, albumin, whey; choline chloride, phosphorylcholine; placental extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayobara extract, yarrow extract Animal / plant extract components such as eucalyptus extract and merirot extract, natural ceramide (type 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide and sugar ceramide-containing extract Ceramides can be mentioned as preferred.
界面活性剤としては、陰イオン性界面活性剤、非イオン性界面活性剤、陽イオン性界面活性剤、両性界面活性剤、高分子界面活性剤等が好ましいものとして挙げられる。界面活性剤のHLBには特に制限はなく、1程度の低いものから20程度の高いものまで使用でき、HLB低いものと高いものを組み合わせることも好ましい。界面活性剤として好ましいものを例示すると、陰イオン性界面活性剤では、ラウリン酸カリウム、ミリスチン酸カリウム等の脂肪酸塩;ラウリル硫酸ナトリウム、ラウリル硫酸トリエタノールアミン、ラウリル硫酸アンモニウム等のアルキル硫酸エステル塩;ラウレス硫酸ナトリウム、ラウレス硫酸トリエタノールアミン等のポリオキシエチレンアルキル硫酸塩;ココイルメチルタウリンナトリウム、ココイルメチルタウリンカリウム、ラウロイルメチルタウリンナトリウム、ミリストイルメチルタウリンナトリウム、ラウロイルメチルアラニンナトリウム、ラウロイルサルコシンナトリウム、ラウロイルサルコシントリエタノールアミン、ラウロイルグルタミン酸メチルアラニンナトリウム等のアシルN−メチルアミノ酸塩;ココイルグルタミン酸ナトリウム、ココイルグルタミン酸トリエタノールアミン、ラウロイルグルタミン酸ナトリウム、ミリストイルグルタミン酸ナトリウム、ステアロイルグルタミン酸ナトリウム、パルミトイルアスパラギン酸ジトリエタノールアミン、ココイルアラニントリエタノールアミン、ジラウロイルグルタミン酸リシンNa等のアシルアミノ酸塩;ラウレス酢酸ナトリウム等のポリオキシエチレンアルキルエーテル酢酸塩;ラウロイルモノエタノールアミドコハク酸ナトリウム等のコハク酸エステル塩;脂肪酸アルカノールアミドエーテルカルボン酸塩;アシル乳酸塩;ポリオキシエチレン脂肪アミン硫酸塩;脂肪酸アルカノールアミド硫酸塩;硬化ヤシ油脂肪酸グリセリン硫酸ナトリウム等の脂肪酸グリセリド硫酸塩;アルキルベンゼンポリオキシエチレン硫酸塩;α−オレフィンスルホン酸ナトリウム等のオレフィンスルホン酸塩;スルホコハク酸ラウリル2ナトリウム、スルホコハク酸ジオクチルナトリウム等のアルキルスルホコハク酸塩;スルホコハク酸ラウレス2ナトリウム、モノラウロイルモノエタノールアミドポリオキシエチレンスルホコハク酸ナトリウム、ラウリルポリプロピレングリコールスルホコハク酸ナトリウム等のアルキルエーテルスルホコハク酸塩;テトラデシルベンゼンスルホン酸ナトリウム、テトラデシルベンゼンスルホン酸トリエタノールアミン等のアルキルベンゼンスルホン酸塩;アルキルナフタレンスルホン酸塩;アルカンスルホン酸塩;α−スルホ脂肪酸メチルエステル塩;アシルイセチオン酸塩;アルキルグリシジルエーテルスルホン酸塩;アルキルスルホ酢酸塩;ラウレスリン酸ナトリウム、ジラウレスリン酸ナトリウム、トリラウレスリン酸ナトリウム、モノオレスリン酸ナトリウム等のアルキルエーテルリン酸エステル塩;ラウリルリン酸カリウム等のアルキルリン酸エステル塩;カゼインナトリウム;アルキルアリールエーテルリン酸塩;脂肪酸アミドエーテルリン酸塩;ホスファチジルグリセロール、ホスファチジルイノシトール、ホスファチジン酸、環状リゾホスファチジン酸またはその塩等のリン脂質類;カルボン酸変性シリコーン、リン酸変性シリコーン、硫酸変性シリコーン等のシリコーン系陰イオン性界面活性剤等;非イオン界面活性剤では、ラウレス(ポリオキシエチレンラウリルエーテル)類、セテス(ポリオキシエチレンセチルエーテル)類、ステアレス(ポリオキシエチレンステアリルエーテル)類、ベヘネス類(ポリオキシエチレンベヘニルエーテル)、イソステアレス(ポリオキシエチレンイソステアリルエーテル)類、オクチルドデセス(ポリオキシエチレンオクチルドデシルエーテル)類等の種々のポリオキシエチレン付加数のポリオキシエチレンアルキルエーテル類;ポリオキシエチレンアルキルフェニルエーテル;ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンヒマシ油、ポリオキシエチレン硬化ヒマシ油モノイソステアレート、ポリオキシエチレン硬化ヒマシ油トリイソステアレート、ポリオキシエチレン硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、ポリオキシエチレン硬化ヒマシ油マレイン酸等のヒマシ油及び硬化ヒマシ油誘導体;ポリオキシエチレンフィトステロール;ポリオキシエチレンコレステロール;ポリオキシエチレンコレスタノール;ポリオキシエチレンラノリン;ポリオキシエチレン還元ラノリン;ポリオキシエチレン・ポリオキシプロピレンセチルエーテル、ポリオキシエチレン・ポリオキシプロピレン2−デシルテトラデシルエーテル、ポリオキシエチレン・ポリオキシプロピレンモノブチルエーテル、ポリオキシエチレン・ポリオキシプロピレン水添ラノリン、ポリオキシエチレン・ポリオキシプロピレングリセリンエーテル等のポリオキシエチレン・ポリオキシプロピレンアルキルエーテル;ポリオキシエチレン・ポリオキシプロピレングリコール;PPG−9ジグリセリル等の(ポリ)グリセリンポリオキシプロピレングリコール;ステアリン酸グリセリル、イソステアリン酸グリセリル、パルミチン酸グリセリル、ミリスチン酸グリセリル、オレイン酸グリセリル、ヤシ油脂肪酸グリセリル、モノ綿実油脂肪酸グリセリン、モノエルカ酸グリセリン、セスキオレイン酸グリセリン、α,α’−オレイン酸ピログルタミン酸グリセリン、モノステアリン酸グリセリンリンゴ酸等のグリセリン脂肪酸部分エステル類;ステアリン酸ポリグリセリル−2、同3、同4、同5、同6、同8、同10、ジステアリン酸ポリグリセリル−6、同10、トリステアリン酸ポリグリセリル−2、デカステアリン酸ポリグリセリル−10、イソステアリン酸ポリグリセリル−2、同3、同4、同5、同6、同8、同10、ジイソステアリン酸ポリグリセリル−2(ジイソステアリン酸ジグリセリル)、同3、同10、トリイソステアリン酸ポリグリセリル−2、テトライソステアリン酸ポリグリセリル−2、デカイソステアリン酸ポリグリセリル−10、オレイン酸ポリグリセリル−2、同3、同4、同5、同6、同8、同10、ジオレイン酸ポリグリセリル−6、トリオレイン酸ポリグリセリル−2、デカオレイン酸ポリグリセリル−10等のポリグリセリン脂肪酸エステル;モノステアリン酸エチレングリコール等のエチレングリコールモノ脂肪酸エステル;モノステアリン酸プロピレングリコール等のプロピレングリコールモノ脂肪酸エステル;ペンタエリスリトール部分脂肪酸エステル;ソルビトール部分脂肪酸エステル;マルチトール部分脂肪酸エステル;マルチトールエーテル;ソルビタンモノオレエート、ソルビタンモノイソステアレート、ソルビタンモノラウレート、ソルビタンモノパルミテート、ソルビタンモノステアレート、ソルビタンセスキオレエート、ソルビタントリオレエート、ペンタ−2−エチルヘキシル酸ジグリセロールソルビタン、テトラ−2−エチルヘキシル酸ジグリセロールソルビタン等のソルビタン脂肪酸エステル;ショ糖脂肪酸エステル、メチルグルコシド脂肪酸エステル、ウンデシレン酸トレハロース等の糖誘導体部分エステル;カプリリルグルコシド等のアルキルグルコシド;アルキルポリグリコシド;マンノシルエリスリトールリピッド等の糖脂質;ラノリンアルコール;還元ラノリン;ポリオキシエチレンジステアレート、ポリチレングリコールジイソステアレート、ポリオキシエチレンモノオレエート、ポリオキシエチレンジオレエート等のポリオキシエチレン脂肪酸モノ及びジエステル;ポリオキシエチレン・プロピレングリコール脂肪酸エステル;ポリオキシエチレングリセリンモノステアレート、ポリオキシエチレングリセリンモノイソステアレート、ポリオキシエチレングリセリントリイソステアレート等のポリオキシエチレンモノオレエート等のポリオキシエチレングリセリン脂肪酸エステル;ポリオキシエチレンソルビタンモノオレエート、ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレンソルビタンモノオレート、ポリオキシエチレンソルビタンテトラオレエート等のポリオキシエチレンソルビタン脂肪酸エステル;ポリオキシエチレンソルビトールモノラウレート、ポリオキシエチレンソルビトールモノオレエート、ポリオキシエチレンソルビトールペンタオレエート、ポリオキシエチレンソルビトールモノステアレート等のポリオキシエチレンソルビトール脂肪酸エステル;ポリオキシエチレンメチルグルコシド脂肪酸エステル;ポリオキシエチレンアルキルエーテル脂肪酸エステル;ポリオキシエチレンソルビトールミツロウ等のポリオキシエチレン動植物油脂類;イソステアリルグリセリルエーテル、キミルアルコール、セラキルアルコール、バチルアルコール等のアルキルグリセリルエーテル類;多価アルコールアルキルエーテル;ポリオキシエチレンアルキルアミン;テトラポリオキシエチレン・テトラポリオキシプロピレン−エチレンジアミン縮合物類;サポニン、ソホロリピッド等の天然系界面活性剤;ポリオキシエチレン脂肪酸アミド;ヤシ油脂肪酸モノエタノールアミド(コカミドMEA)、ヤシ油脂肪酸ジエタノールアミド(コカミドDEA)、ラウリン酸モノエタノールアミド(ラウラミドMEA)、ラウリン酸ジエタノールアミド(ラウラミドDEA)、ラウリン酸モノイソプロパノールアミド(ラウラミドMIPA)、パルミチン酸モノエタノールアミド(パルタミドMEA)、パルミチン酸ジエタノールアミド(パルタミドDEA)、ヤシ油脂肪酸メチルエタノールアミド(コカミドメチルMEA)等の脂肪酸アルカノールアミド類;ラウラミンオキシド、コカミンオキシド、ステアラミンオキシド、ベヘナミンオキシド等のアルキルジメチルアミンオキシド;アルキルエトキシジメチルアミンオキシド;ポリオキシエチレンアルキルメルカプタン;ジメチコンコポリオール等のポリエーテル変性シリコーン、ポリシロキサン・オキシアルキレン共重合体、ポリグリセリン変性シリコーン、糖変性シリコーン等のシリコーン系非イオン性界面活性剤等;陽イオン性界面活性剤では、ベヘントリモニウムクロリド、ステアルトリモニウムクロリド、セトリモニウムクロリド、ラウリルトリモニウムクロリド等のアルキルトリメチルアンモニウムクロリド;ステアリルトリモニウムブロミド等のアルキルトリメチルアンモニウムブロミド;ジステアリルジモニウムクロリド、ジココジモニウムクロリド等のジアルキルジメチルアンモニウムクロリド;ステアラミドプロピルジメチルアミン、ステアラミドエチルジエチルアミン等の脂肪酸アミドアミン及びその塩;ステアロキシプロピルジメチルアミン等のアルキルエーテルアミン及びその塩または四級塩;エチル硫酸長鎖分岐脂肪酸(12〜31)アミノプロピルエチルジメチルアンモニウム、エチル硫酸ラノリン脂肪酸アミノプロピルエチルジメチルアンモニウム等の脂肪酸アミド型四級アンモニウム塩;ポリオキシエチレンアルキルアミン及びその塩または四級塩;アルキルアミン塩;脂肪酸アミドグアニジウム塩;アルキルエーテルアミンモニウム塩;アルキルトリアルキレングリコールアンモニウム塩;ベンザルコニウム塩;ベンゼトニウム塩;塩化セチルピリジニウム等のピリジニウム塩;イミダゾリニウム塩;アルキルイソキノリニウム塩;ジアルキルモリホニウム塩;ポリアミン脂肪酸誘導体;アミノプロピルジメチコン及びアモジメチコン等のアミノ変性シリコーン、カチオン変性シリコーン、カチオン変性及びポリエーテル変性シリコーン、アミノ変性及びポリエーテル変性シリコーン等のシリコーン系陽イオン性界面活性剤等;両性界面活性剤では、ラウリルベタイン(ラウリルジメチルアミノ酢酸ベタイン)等のN−アルキル−N,N−ジメチルアミノ酸ベタイン;コカミドプロピルベタイン、ラウラミドプロピルベタイン等の脂肪酸アミドアルキル−N,N−ジメチルアミノ酸ベタイン;ココアンホ酢酸ナトリウム、ラウロアンホ酢酸ナトリウム等のイミダゾリン型ベタイン;アルキルジメチルタウリン等のアルキルスルホベタイン;アルキルジメチルアミノエタノール硫酸エステル等の硫酸型ベタイン;アルキルジメチルアミノエタノールリン酸エステル等のリン酸型ベ
タイン;ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、スフィンゴミエリン等のスフィンゴリン脂質、リゾレシチン、水素添加大豆リン脂質、部分水素添加大豆リン脂質、水素添加卵黄リン脂質、部分水素添加卵黄リン脂質、水酸化レシチン等のリン脂質類;シリコーン系両性界面活性剤等;高分子界面活性剤では、ポリビニルアルコール、アルギン酸ナトリウム、デンプン誘導体、トラガントガム、アクリル酸・メタアクリル酸アルキル共重合体;シリコーン系各種界面活性剤が好ましいものとして挙げられる。
Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acylamino acid salts such as sodium phosphate, triethanolamine cocoylglutamate, sodium lauroylglutamate, sodium myristoylglutamate, sodium stearoylglutamate, ditriethanolamine palmitoylaspartate, cocoylalaninetriethanolamine, lysine Nadilauroylglutamate; sodium laureth acetate, etc. Polyoxyethylene alkyl ether acetates; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; Fatty acid glyceride sulfate such as coconut oil fatty acid sodium glycerin sulfate; Oxyethylene sulfate; Olefin sulfonate such as sodium α-olefin sulfonate; Alkyl sulfosuccinate such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; Disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate Alkyl ether sulfosuccinates such as sodium acid, sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonate; alkanesulfonate; α-sulfo fatty acid methyl ester salt; acyl isethionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetates; alkyl ether phosphates such as sodium laureth phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate esters such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphorus Acid salts; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof; silicone-based shades such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone Nonionic surfactants such as ionic surfactants, laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steale Various polyoxyethylene addition numbers such as bis (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether), octyldecesses (polyoxyethylene octyldodecyl ether) Polyoxyethylene alkyl ethers; polyoxyethylene alkyl phenyl ethers; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, Castor oil and hardened castor oil derivatives such as polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hardened castor oil maleic acid; Polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether; Polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol ; (Poly) glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; Glyceryl isostearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl palm oil fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-pyroglutamate oleate, monostearate Glycerin fatty acid partial esters such as glyceryl malic acid; polyglyceryl stearate-2, 3, 4, 5, 6, 8, 8, disglyceryl-6, 10, polyglyceryl tristearate 2, polyglyceryl-10 decastearate, polyglyceryl-2 isostearate, 3, 4, 5, 6, 6, 8, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 1 Polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, dioleate polyglyceryl- 6, polyglyceryl fatty acid ester such as polyglyceryl-2 trioleate, polyglyceryl-10 decaoleate; ethylene glycol mono fatty acid ester such as ethylene glycol monostearate; propylene glycol mono fatty acid ester such as propylene glycol monostearate; pentaerythritol moiety Fatty acid ester; sorbitol partial fatty acid ester; maltitol partial fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate Sorbitan fatty acid esters such as sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; Sugar derivatives partial esters such as sucrose fatty acid ester, methyl glucoside fatty acid ester and undecylenic acid trehalose; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; glycolipid such as mannosyl erythritol lipid; lanolin alcohol; reduced lanolin; Stearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate, etc. Polyoxyethylene fatty acid mono- and diesters; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene sorbitan monooleate; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate, and other polyoxyethylene sorbitan fatty acid esters; poly Oxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene Polyoxyethylene sorbitol fatty acid esters such as bitol pentaoleate and polyoxyethylene sorbitol monostearate; Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax Alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; Natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil fatty acid monoethano Luamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide Fatty acid alkanolamides such as (partamide MEA), palmitic acid diethanolamide (partamide DEA), and palm oil fatty acid methylethanolamide (cocamidomethyl MEA); alkyl such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide Polydimethyl ether oxide; alkyl ethoxy dimethyl amine oxide; polyoxyethylene alkyl mercaptan; polyether such as dimethicone copolyol Silicone-based nonionic surfactants such as silicone-modified silicones, polysiloxane / oxyalkylene copolymers, polyglycerin-modified silicones, sugar-modified silicones, etc .; for cationic surfactants, behentrimonium chloride, steartrimonium chloride Alkyltrimethylammonium chloride such as cetrimonium chloride and lauryltrimonium chloride; alkyltrimethylammonium bromide such as stearyltrimonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; stearamidepropyldimethylamine; Fatty acid amidoamines such as stearamide ethyl diethylamine and salts thereof; alkyl ether amines such as stearoxypropyldimethylamine; and Salt or quaternary salt of fatty acid amide type quaternary ammonium salt such as ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamine and its Alkylamine salt; fatty acid amidoguanidinium salt; alkyl etheraminemonium salt; alkyltrialkylene glycol ammonium salt; benzalkonium salt; benzethonium salt; pyridinium salt such as cetylpyridinium chloride; imidazolinium salt Alkyl isoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyl dimethicone and amodimethicone; cation-modified silicones; And silicone-based cationic surfactants such as polyether-modified silicones, amino-modified and polyether-modified silicones, etc .; in amphoteric surfactants, N-alkyl-N, N- such as laurylbetaine (lauryldimethylaminoacetic acid betaine) Dimethylamino acid betaine; fatty acid amide alkyl-N, N-dimethylamino acid betaine such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline type betaine such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyl sulfobetaine such as alkyldimethyltaurine; alkyl Sulfate-type betaines such as dimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; phosphatidylcholine, phosphatidylethanolamine , Sphingophospholipids such as phosphatidylserine and sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, hydroxylated lecithin, etc .; silicone Preferred examples of the polymeric surfactant include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymer, and various silicone surfactants.
高分子・増粘剤・ゲル化剤としては、グアーガム、ローカストビーンガム、クィーンスシード、カラギーナン、ガラクタン、アラビアガム、タラガム、タマリンド、ファーセレラン、カラヤガム、トロロアオイ、キャラガム、トラガントガム、ペクチン、ペクチン酸及びナトリウム塩等の塩、アルギン酸及びナトリウム塩等の塩、マンナン;コメ、トウモロコシ、バレイショ、コムギ等のデンプン;キサンタンガム、デキストラン、サクシノグルカン、カードラン、ヒアルロン酸及びその塩、ザンサンガム、プルラン、ジェランガム、キチン、キトサン、寒天、カッソウエキス、コンドロイチン硫酸塩、カゼイン、コラーゲン、ゼラチン、アルブミン;メチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロース及びそのナトリウム等の塩、メチルヒドロキシプロピルセルロース、セルロース硫酸ナトリウム、ジアルキルジメチルアンモニウム硫酸セルロース、結晶セルロース、セルロース末等のセルロース及びその誘導体;可溶性デンプン、カルボキシメチルデンプン、メチルヒドロキシプロピルデンプン、メチルデンプン等のデンプン系高分子、塩化ヒドロキシプロピルトリモニウムデンプン、オクテニルコハク酸トウモロコシデンプンアルミニウム等のデンプン誘導体;アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等アルギン酸誘導体;ポリビニルピドリドン(PVP)、ポリビニルアルコール(PVA)、ビニルピドリドン・ビニルアルコール共重合体、ポリビニルメチルエーテル;ポリエチレングリコール、ポリプロピレングリコール、ポリオキシエチレン・ポリオキシプロピレン共重合体;(メタクリロイルオキシエチルカルボキシベタイン/メタクリル酸アルキル)コポリマー、(アクリレーツ/アクリル酸ステアリル/メタクリル酸エチルアミンオキシド)コポリマー等の両性メタクリル酸エステル共重合体;(ジメチコン/ビニルジメチコン)クロスポリマー、(アクリル酸アルキル/ジアセトンアクリルアミド)コポリマー、(アクリル酸アルキル/ジアセトンアクリルアミド)コポリマーAMP;ポリ酢酸ビニル部分けん化物、マレイン酸共重合体;ビニルピロリドン・メタクリル酸ジアルキルアミノアルキル共重合体;アクリル樹脂アルカノールアミン;ポリエステル、水分散性ポリエステル;ポリアクリルアミド;ポリアクリル酸エチル等のポリアクリル酸エステル共重合体、カルボキシビニルポリマー、ポリアクリル酸及びそのナトリウム塩等の塩、アクリル酸・メタアクリル酸エステル共重合体;アクリル酸・メタアクリル酸アルキル共重合体;ポリクオタニウム−10等のカチオン化セルロース、ポリクオタニウム−7等のジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、ポリクオタニウム−22等のアクリル酸・ジアリルジメチルアンモニウムクロリド共重合体、ポリクオタニウム−39等のアクリル酸・ジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、アクリル酸・カチオン化メタアクリル酸エステル共重合体、アクリル酸・カチオン化メタアクリル酸アミド共重合体、ポリクオタニウム−47等のアクリル酸・アクリル酸メチル・塩化メタクリルアミドプロピルトリメチルアンモニウム共重合体、塩化メタクリル酸コリンエステル重合体;カチオン化オリゴ糖、カチオン化デキストラン、グアーヒドロキシプロピルトリモニウムクロリド等のカチオン化多糖類;ポリエチレンイミン;カチオンポリマー;ポリクオタニウム−51等の2−メタクリロイルオキシエチルホスホリルコリンの重合体及びメタクリル酸ブチル共重合体等との共重合体;アクリル樹脂エマルジョン、ポリアクリル酸エチルエマルジョン、ポリアクリルアルキルエステルエマルジョン、ポリ酢酸ビニル樹脂エマルジョン、天然ゴムラテックス、合成ラテックス等の高分子エマルジョン;ニトロセルロース;ポリウレタン類及び各種共重合体;各種シリコーン類;アクリル−シリコーングラフト共重合体等のシリコーン系各種共重合体;各種フッ素系高分子;12−ヒドロキシステアリン酸及びその塩;パルミチン酸デキストリン、ミリスチン酸デキストリン等のデキストリン脂肪酸エステル;無水ケイ酸、煙霧状シリカ(超微粒子無水ケイ酸)、ケイ酸アルミニウムマグネシウム、ケイ酸ナトリウムマグネシウム、金属石鹸、ジアルキルリン酸金属塩、ベントナイト、ヘクトライト、有機変性粘土鉱物、ショ糖脂肪酸エステル、フラクトオリゴ糖脂肪酸エステルが好ましいものとして挙げられる。 Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.
溶剤・噴射剤類としては、エタノール、2−プロパノール(イソプロピルアルコール)、ブタノール、イソブチルアルコール等の低級アルコール類;プロピレングリコール、1,3−ブチレングリコール、ジエチレングリコール、ジプロピレングリコール、イソペンチルジオール等のグリコール類;ジエチレングリコールモノエチルエーテル(エトキシジグリコール)、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、トリエチレングリコールモノエチルエーテル、ジエチレングリコールジエチルエーテル、ジエチレングリコールジブチルエーテル、プロピレングリコールモノエチルエーテル、ジプロピレングリコールモノエチルエーテル等のグリコールエーテル類;エチレングリコールモノエチルエーテルアセテート、ジエチレングリコールモノエチルエーテルアセテート、プロピレングリコールモノエチルエーテルアセテート等のグリコールエーテルエステル類;コハク酸ジエトキシエチル、エチレングリコールジサクシネート等のグリコールエステル類;ベンジルアルコール、ベンジルオキシエタノール、炭酸プロピレン、炭酸ジアルキル、アセトン、酢酸エチル、N−メチルピロリドン;トルエン;フルオロカーボン、次世代フロン;LPG、ジメチルエーテル、炭酸ガス等の噴射剤が好ましいものとして挙げられる。 Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.
酸化防止剤としては、トコフェロール(ビタミンE)、酢酸トコフェロール等のトコフェロール誘導体;BHT、BHA;没食子酸プロピル等の没食子酸誘導体;ビタミンC(アスコルビン酸)および/またはその誘導体;エリソルビン酸及びその誘導体;亜硫酸ナトリウム等の亜硫酸塩;亜硫酸水素ナトリウム等の亜硫酸水素塩;チオ硫酸ナトリウム等のチオ硫酸塩;メタ亜硫酸水素塩;チオタウリン、ヒポタウリン;チオグリセロール、チオ尿素、チオグリコール酸、システイン塩酸塩が好ましいものとして挙げられる。還元剤としては、チオグリコール酸、システイン、システアミン等が好ましいものとして挙げられる。酸化剤としては、過酸化水素水、過硫酸アンモニウム、臭素酸ナトリウム、過炭酸等が好ましいものとして挙げられる。 Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.
抗菌剤又は防腐剤としては、メチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベン等のパラベン(ヒドロキシ安息香酸エステル)類;フェノキシエタノール;1,2−ペンタンジオール、1,2−ヘキサンジオール、1,2−オクタンジオール等の1,2−アルカンジオール類;2−エチルヘキシルグリセリルエーテル(エチルヘキシルグリセリン)等のアルキルグリセリルエーテル類;サリチル酸;安息香酸ナトリウム;メチルクロロイソチアゾリノン、メチルイソチアゾリノン等のイソチアゾリンオン誘導体;イミダゾリニウムウレア;デヒドロ酢酸及びその塩;フェノール類;トリクロサン等のハロゲン化ビスフェノール類、酸アミド類、四級アンモニウム塩類;トリクロロカルバニド、ジンクピリチオン、塩化ベンザルコニウム、塩化ベンゼトニウム、ソルビン酸、クロルヘキシジン、グルコン酸クロルヘキシジン、ハロカルバン、ヘキサクロロフェン、ヒノキチオール;フェノール、イソプロピルフェノール、クレゾール、チモール、パラクロロフェノール、フェニルフェノール、フェニルフェノールナトリウム等のその他フェノール類;フェニルエチルアルコール、感光素類、抗菌性ゼオライト、銀イオンが好ましいものとして挙げられるが、防腐を目的とした抗菌剤又は防腐剤として用いる場合は、化粧料又は皮膚外用剤の安全性の観点から、フェノキシエタノール;1,2−ペンタンジオール、1,2−ヘキサンジオール、1,2−オクタンジオール等の1,2−アルカンジオール類;2−エチルヘキシルグリセリルエーテル等のアルキルグリセリルエーテル類を用いることが、より好ましい。 Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazoline derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzoyl chloride Luconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol , Photosensitizers, antibacterial zeolite, and silver ion are preferable, but when used as an antibacterial agent or antiseptic agent for antiseptic purposes, phenoxyethanol; 1 from the viewpoint of safety of cosmetics or skin external preparations; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.
キレート剤としては、EDTA、EDTA2Na、EDTA3Na、EDTA4Na等のエデト酸塩(エチレンジアミン四酢酸塩);HEDTA3Na等のヒドロキシエチルエチレンジアミン三酢酸塩;ペンテト酸塩(ジエチレントリアミン五酢酸塩);フィチン酸;エチドロン酸等のホスホン酸及びそのナトリウム塩等の塩類;シュウ酸ナトリウム;ポリアスパラギン酸、ポリグルタミン酸等のポリポリアミノ酸類;ポリリン酸ナトリウム、メタリン酸ナトリウム、リン酸;クエン酸ナトリウム、クエン酸、アラニン、ジヒドロキシエチルグリシン、グルコン酸、アスコルビン酸、コハク酸、酒石酸が好ましいものとして挙げられる。pH調整剤・酸・アルカリとしては、クエン酸、クエン酸ナトリウム、乳酸、乳酸ナトリウム、グリコール酸、コハク酸、酢酸、酢酸ナトリウム、リンゴ酸、酒石酸、フマル酸、リン酸、塩酸、硫酸、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、イソプロパノールアミン、トリイソプロパノールアミン、2−アミノ−2−メチル−1,3ープロパンジオール、2−アミノ−2−ヒドロキシメチル−1,3ープロパンジオール、アルギニン、水酸化ナトリウム、水酸化カリウム、アンモニア水、炭酸グアニジン、炭酸アンモニウムが好ましいものとして挙げられる。 Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.
粉体類としては、マイカ、タルク、カオリン、セリサイト、モンモリロナイト、カオリナイト、雲母、白雲母、金雲母、合成雲母、紅雲母、黒雲母、パーミキュライト、炭酸マグネシウム、炭酸カルシウム、ケイ酸アルミニウム、ケイ酸バリウム、ケイ酸カルシウム、ケイ酸マグネシウム、ケイ酸ストロンチウム、タングステン酸金属塩、マグネシウム、ゼオライト、硫酸バリウム、焼成硫酸カルシウム、リン酸カルシウム、弗素アパタイト、ヒドロキシアパタイト、セラミックパウダー、ベントナイト、スメクタイト、粘土、泥、金属石鹸(例えば、ミリスチン酸亜鉛、パルミチン酸カルシウム、ステアリン酸アルミニウム)、炭酸カルシウム、ベンガラ、黄酸化鉄、黒酸化鉄、群青、紺青、カーボンブラック、酸化チタン、微粒子及び超微粒子酸化チタン、酸化亜鉛、微粒子及び超微粒子酸化亜鉛、アルミナ、シリカ、煙霧状シリカ(超微粒子無水ケイ酸)、雲母チタン、魚鱗箔、窒化ホウ素、ホトクロミック顔料、合成フッ素金雲母、微粒子複合粉体、金、アルミニウム等の各種の大きさ・形状の無機粉体、及び、これらをハイドロジェンシリコーン、環状ハイドロジェンシリコーン等のシリコーン若しくはその他のシラン若しくはチタンカップリング剤等の各種表面処理剤で処理を行って疎水化若しくは親水化した粉体等の無機粉体;デンプン、セルロース、ナイロンパウダー、ポリエチレン末、ポリメタクリル酸メチル末、ポリスチレン末、スチレンとアクリル酸の共重合体樹脂粉末、ポリエステル末、ベンゾグアナミン樹脂粉末、ポリエチレンテレフタレート・ポリメチルメタクリレート積層末、ポリエチレンテレフタレート・アルミニウム・エポキシ積層末等、ウレタン粉末、シリコーン粉末、テフロン(登録商標)粉末等の各種の大きさ・形状の有機系粉体及び表面処理粉体、有機無機複合粉体が好ましいものとして挙げられる。無機塩類としては、食塩、並塩、岩塩、海塩、天然塩等の塩化ナトリウム含有塩類;塩化カリウム、塩化アルミニウム、塩化カルシウム、塩化マグネシウム、にがり、塩化亜鉛、塩化アンモニウム;硫酸ナトリウム、硫酸アルミニウム、硫酸アルミニウム・カリウム(ミョウバン)、硫酸アルミニウム・アンモニウム、硫酸バリウム、硫酸カルシウム、硫酸カリウム、硫酸マグネシウム、硫酸亜鉛、硫酸鉄、硫酸銅;リン酸1Na・2Na・3Na等のリン酸ナトリウム類、リン酸カリウム類、リン酸カルシウム類、リン酸マグネシウム類が好ましいものとして挙げられる。 Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.
紫外線吸収剤としては、パラアミノ安息香酸、パラアミノ安息香酸モノグリセリンエステル、N,N−ジプロポキシパラアミノ安息香酸エチルエステル、N,N−ジエトキシパラアミノ安息香酸エチルエステル、N,N−ジメチルパラアミノ安息香酸エチルエステル、N,N−ジメチルパラアミノ安息香酸ブチルエステル、N,N−ジメチルパラアミノ安息香酸エチルエステル等の安息香酸系紫外線吸収剤;ホモメンチル−N−アセチルアントラニレート等のアントラニル酸系紫外線吸収剤;サリチル酸及びそのナトリウム塩、アミルサリシレート、メンチルサリシレート、ホモメンチルサリシレート、オクチルサリシレート、フェニルサリシレート、ベンジルサリシレート、p−イソプロパノールフェニルサリシレート等のサリチル酸系紫外線吸収剤;オクチルシンナメート、エチル−4−イソプロピルシンナメート、メチル−2,5−ジイソプロピルシンナメート、エチル−2,4−ジイソプロピルシンナメート、メチル−2,4−ジイソプロピルシンナメート、プロピル−p−メトキシシンナメート、イソプロピル−p−メトキシシンナメート、イソアミル−p−メトキシシンナメート、2−エチルヘキシルp−メトキシシンナメート(パラメトキシケイヒ酸オクチル)、2−エトキシエチル−p−メトキシシンナメート(シノキサート)、シクロヘキシル-p-メトキシシンナメート、エチル−α−シアノ−β−フェニルシンナメート、2−エチルヘキシルα−シアノ−β−フェニルシンナメート(オクトクリン)、グリセリルモノ−2−エチルヘキサノイル−ジパラメトキシシンナメート、フェルラ酸及びその誘導体等の桂皮酸系紫外線吸収剤;2,4−ジヒドロキシベンゾフェノン、2,2’−ジヒドロキシ−4−メトキシベンゾフェノン、2,2’−ジヒドロキシ−4,4’−ジメトキシベンゾフェノン、2,2’,4,4’−テトラヒドロキシベンゾフェノン、2−ヒドロキシ−4−メトキシベンゾフェノン(オキシベンゾン−3)、2−ヒドロキシ−4−メトキシ−4’−メチルベンゾフェノン、2−ヒドロキシ−4−メトキシベンゾフェノン−5−スルホン酸塩、4−フェニルベンゾフェノン、2−エチルヘキシル−4’−フェニル−ベンゾフェノン−2−カルボキシレート、2−ヒドロキシ−4−n−オクトキシベンゾフェノン、4−ヒドロキシ−3−カルボキシベンゾフェノン等のベンゾフェノン系紫外線吸収剤;3−(4’−メチルベンジリデン)−d,l−カンファー、3−ベンジリデン−d,l−カンファー;2−フェニル−5−メチルベンゾキサゾール;2,2’−ヒドロキシ−5−メチルフェニルベンゾトリアゾール;2−(2’−ヒドロキシ−5’−t−オクチルフェニル)ベンゾトリアゾール;2−(2’−ヒドロキシ−5’−メチルフェニルベンゾトリアゾール;ジベンザラジン;ジアニソイルメタン;5−(3,3−ジメチル−2−ノルボルニリデン)−3−ペンタン−2−オン;4−t−ブチルメトキシジベンゾイルメタン等のジベンゾイルメタン誘導体;オクチルトリアゾン;ウロカニン酸及びウロカニン酸エチル等のウロカニン酸誘導体;2−(2'−ヒドロキシ−5'−メチルフェニル)ベンゾトリアゾール、1−(3,4−ジメトキシフェニル)−4,4−ジメチル−1,3−ペンタンジオン、ジメトキシベンジリデンジオキソイミダゾリジンプロピオン酸2−エチルヘキシル等のヒダントイン誘導体、フェニルベンズイミダソゾールスルホン酸、テレフタリリデンジカンフルスルホン酸、ドロメトリゾールトリシロキサン、アントラニル酸メチル、ルチン及びその誘導体、オリザノール及びその誘導体が好ましいものとして挙げられる。 Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid-based UV absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone purple 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphsulfone Preference is given to acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.
ビタミン類及びその誘導体類としては、レチノール、酢酸レチノール、パルミチン酸レチノール等のビタミンA類;チアミン塩酸塩、チアミン硫酸塩、リボフラビン、酢酸リボフラビン、塩酸ピリドキシン、ピリドキシンジオクタノエート、ピリドキシンジパルミテート、フラビンアデニンジヌクレオチド、シアノコバラミン、葉酸類、ニコチン酸アミド・ニコチン酸ベンジル等のニコチン酸類、コリン類等のビタミンB群類;アスコルビン酸及びそのナトリウム等の塩等のビタミンC類;ビタミンD;α、β、γ、δ−トコフェロール等のビタミンE類;パントテン酸、ビオチン等のその他ビタミン類;アスコルビン酸リン酸エステルナトリウム塩及びアスコルビン酸リン酸エステルマグネシウム塩等のアスコルビン酸リン酸エステル塩、アスコルビン酸テトライソパルミチン酸エステル・ステアリン酸アスコルビル・パルミチン酸アスコルビル・ジパルミチン酸アスコルビル等のアスコルビン酸脂肪酸エステル、アスコルビン酸エチルエーテル等のアスコルビン酸アルキルエーテル、アスコルビン酸−2−グルコシド等のアスコルビン酸グルコシド及びその脂肪酸エステル、リン酸トコフェリルアスコルビル等のアスコルビン酸誘導体;ニコチン酸トコフェロール、酢酸トコフェロール、リノール酸トコフェロール、フェルラ酸トコフェロール、トコフェロールリン酸エステル等のトコフェロール誘導体等のビタミン誘導体、トコトリエノール、その他各種ビタミン誘導体類が好ましいものとして挙げられる。 Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.
消炎剤・抗炎症剤としては、グリチルリチン酸及びその誘導体、グリチルレチン酸誘導体、サリチル酸誘導体、ヒノキチオール、グアイアズレン、アラントイン、インドメタシン、酸化亜鉛、酢酸ヒドロコーチゾン、プレドニゾン、塩酸ジフェドラミン、マレイン酸クロルフェニラミン;桃葉エキス、蓬葉エキス等の植物エキスが好ましいものとして挙げられる。育毛用薬剤・血行促進剤・刺激剤としては、センブリエキス、トウガラシチンキ、ショウキョウチンキ、ショウキョウエキス、カンタリスチンキ等の植物エキス・チンキ類;カプサイシン、ノニル酸ワレニルアミド、ジンゲロン、イクタモール、タンニン酸、ボルネオール、シクランデレート、シンナリジン、トラゾリン、アセチルコリン、ベラパミル、セファランチン、γ−オリザノール、セファランチン、ビタミンE及びニコチン酸トコフェロール・酢酸トコフェロール等の誘導体、γ−オリザノール、ニコチン酸及びニコチン酸アミド・ニコチン酸ベンジルエステル・イノシトールヘキサニコチネート、ニコチンアルコール等の誘導体、アラントイン、感光素301、感光素401、塩化カプロニウム、ペンタデカン酸モノグリセリド、フラバノノール誘導体、スチグマステロール又はスチグマスタノール及びその配糖体、ミノキシジルが好ましいものとして挙げられる。ホルモン類としては、エストラジオール、エストロン、エチニルエストラジオール、コルチゾン、ヒドロコルチゾン、プレドニゾン等が好ましいものとして挙げられる。抗しわ剤、抗老化剤、ひきしめ剤、冷感剤、温感剤、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤等のその他の薬効剤としては、レチノール類、レチノイン酸類、レチノイン酸トコフェリル;乳酸、グリコール酸、グルコン酸、フルーツ酸、サリチル酸及びその配糖体・エステル化物等の誘導体、ヒドロキシカプリン酸、長鎖α−ヒドロキシ脂肪酸、長鎖α−ヒドロキシ脂肪酸コレステリル等のα−又はβ−ヒドロキシ酸類及びその誘導体類;γ−アミノ酪酸、γ−アミノ−β−ヒドロキシ酪酸;カルニチン;カルノシン;クレアチン;セラミド類、スフィンゴシン類;カフェイン、キサンチン等及びその誘導体;コエンザイムQ10、カロチン、リコピン、アスタキサンチン、ルテイン、α−リポ酸、白金ナノコロイド、フラーレン類等の抗酸化・活性酸素消去剤;カテキン類;ケルセチン等のフラボン類;イソフラボン類;没食子酸及びエステル糖誘導体;タンニン、セサミン、プロトアントシアニジン、クロロゲン酸、リンゴポリフェノール等のポリフェノール類;ルチン及び配糖体等の誘導体;ヘスペリジン及び配糖体等の誘導体;リグナン配糖体;グラブリジン、グラブレン、リクイリチン、イソリクイリチン等のカンゾウエキス関連物質;ラクトフェリン;ショウガオール、ジンゲロール;メントール、カンファー、セドロール等の香料物質及びその誘導体;カプサイシン、バニリン等及び誘導体;ジエチルトルアミド等の昆虫忌避剤;生理活性物質とシクロデキストリン類との複合体が好ましいものとして挙げられる。 Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.
植物・動物・微生物エキス類としては、アイリスエキス、アシタバエキス、アスナロエキス、アスパラガスエキス、アボガドエキス、アマチャエキス、アーモンドエキス、アルテアエキス、アルニカエキス、アロエエキス、アンズエキス、アンズ核エキス、イチョウエキス、インチコウエキス、ウイキョウエキス、ウコンエキス、ウーロン茶エキス、ウワウルシエキス、エイジツエキス、エチナシ葉エキス、エンメイソウエキス、オウゴンエキス、オウバクエキス、オウレンエキス、オオムギエキス、オタネニンジンエキス、オトギリソウエキス、オドリコソウエキス、オノニスエキス、オランダカラシエキス、オレンジエキス、海水乾燥物、海藻エキス、カキ葉エキス、カキョクエキス、加水分解エラスチン、加水分解コムギ末、加水分解シルク、カッコンエキス、カモミラエキス、油溶性カモミラエキス、カロットエキス、カワラヨモギエキス、カラスムギエキス、カルカデエキス、カンゾウエキス、油溶性カンゾウエキス、キウイエキス、キオウエキス、キクラゲエキス、キナエキス、キューカンバーエキス、キリ葉エキス、グアノシン、グアバエキス、クジンエキス、クチナシエキス、クマザサエキス、クララエキス、クルミエキス、クリエキス、グレープフルーツエキス、クレマティスエキス、黒米エキス、黒砂糖抽出物、黒酢、クロレラエキス、クワエキス、ゲンチアナエキス、ゲンノショウコエキス、紅茶エキス、酵母エキス、コウボクエキス、コーヒーエキス、ゴボウエキス、コメエキス、コメ発酵エキス、コメヌカ発酵エキス、コメ胚芽油、コンフリーエキス、コラーゲン、コケモモエキス、サイシンエキス、サイコエキス、サイタイ抽出液、サフランエキス、サルビアエキス、サボンソウエキス、ササエキス、サンザシエキス、サンシャエキス、サンショウエキス、シイタケエキス、ジオウエキス、シコンエキス、シソエキス、シナノキエキス、シモツケソウエキス、ジャトバエキス、シャクヤクエキス、ショウキュウエキス、ショウブ根エキス、シラカバエキス、白キクラゲエキス、スギナエキス、ステビアエキス、ステビア発酵物、西河柳エキス、セイヨウキズタエキス、セイヨウサンザシエキス、セイヨウニワトコエキス、セイヨウノコギリソウエキス、セイヨウハッカエキス、セージエキス、ゼニアオイエキス、センキュウエキス、センブリエキス、ソウハクヒエキス、ダイオウエキス、ダイズエキス、タイソウエキス、タイムエキス、タンポポエキス、地衣類エキス、茶エキス、チョウジエキス、チガヤエキス、チンピエキス、ティートリー油、甜茶エキス、トウガラシエキス、トウキエキス、トウキンセンカエキス、トウニンエキス、トウヒエキス、ドクダミエキス、トマトエキス、納豆エキス、ニンジンエキス、ニンニクエキス、ノバラエキス、ハイビスカスエキス、バクモンドウエキス、ハスエキス、パセリエキス、バーチエキス、蜂蜜、ハマメリスエキス、パリエタリアエキス、ヒキオコシエキス、ビサボロール、ヒノキエキス、ビフィズス菌エキス、ビワエキス、フキタンポポエキス、フキノトウエキス、ブクリョウエキス、ブッチャーブルームエキス、ブドウエキス、ブドウ種子エキス、プロポリス、ヘチマエキス、ベニバナエキス、ペパーミントエキス、ボダイジュエキス、ボタンエキス、ホップエキス、マイカイカエキス、マツエキス、マロニエエキス、ミズバショウエキス、ムクロジエキス、メリッサエキス、モズクエキス、モモエキス、ヤグルマギクエキス、ユーカリエキス、ユキノシタエキス、ユズエキス、ユリエキス、ヨクイニンエキス、ヨモギエキス、ラベンダーエキス、緑茶エキス、卵殻膜エキス、リンゴエキス、ルイボス茶エキス、レイシエキス、レタスエキス、レモンエキス、レンギョウエキス、レンゲソウエキス、ローズエキス、ローズマリーエキス、ローマカミツレエキス、ローヤルゼリーエキス、ワレモコウエキス等のエキスが好ましいものとして挙げられる。 As plant / animal / microbe extracts, Iris extract, Ashitaba extract, Asunaro extract, Asparagus extract, Avocado extract, Achacha extract, Almond extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Ginkgo biloba extract, Ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.
鎮痒剤としては、塩酸ジフェンヒドラミン、マレイン酸クロルフェニラミン、カンファー、サブスタンス−P阻害剤等を例示することができる。角質剥離・溶解剤としては、サリチル酸、イオウ、レゾルシン、硫化セレン、ピリドキシン等を例示することができる。制汗剤としては、クロルヒドロキシアルミニウム、塩化アルミニウム、酸化亜鉛、パラフェノールスルホン酸亜鉛等を例示することができる。清涼剤としては、メントール、サリチル酸メチル等を例示することができる。収れん剤としては、クエン酸、酒石酸、乳酸、硫酸アルミニウム・カリウム、タンニン酸等を例示することができる。酵素類としては、スーパーオキサイドディスムターゼ、カタラーゼ、塩化リゾチーム、リパーゼ、パパイン、パンクレアチン、プロテアーゼ等を例示することができる。核酸類としては、リボ核酸及びその塩、デオキシリボ核酸及びその塩、アデノシン三リン酸二ナトリウムが好ましいものとして挙げられる。 Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.
香料としては、アセチルセドレン、アミルシンナムアルデヒド、アリルアミルグリコレート、β−イオノン、イソイースーパー、イソブチルキノリン、イリス油、イロン、インドール、イランイラン油、ウンデカナール、ウンデセナール、γ−ウンデカラクトン、エストラゴール、オイゲノール、オークモス、オポポナックスレジノイド、オレンジ油、オイゲノール、オーランチオール、ガラクソリッド、カルバクロール、L−カルボン、カンファー、キャノン、キャロットシード油、クローブ油、ケイヒ酸メチル、ゲラニオール、ゲラニルニトリル、酢酸イソボルニル、酢酸ゲラニル、酢酸ジメチルベンジルカルビニル、酢酸スチラリル、酢酸セドリル、酢酸テレピネル、酢酸p-t-ブチルシクロヘキシル、酢酸ベチベリル、酢酸ベンジル、酢酸リナリル、サリチル酸イソペンチル、サリチル酸ベンジル、サンダルウッド油、サンタロール、シクラメンアルデヒド、シクロペンタデカノリド、ジヒドロジャスモン酸メチル、ジヒドロミルセノール、ジャスミンアブソリュート、ジャスミンラクトン、cis-ジャスモン、シトラール、シトロネノール、シトロネラール、シナモンバーク油、1,8−シネオール、シンナムアルデヒド、スチラックスレジノイド、セダーウッド油、セドレン、セドロール、セロリシード油、タイム油、ダマスコン、ダマセノン、チモール、チュベローズアブソリュート、デカナール、デカラクトン、テルピネオール、γ−テルピネン、トリプラール、ネロール、ノナナール、2,6−ノナジエノール、ノナラクトン、パチョリアルコール、バニラアブソリュート、バニリン、バジル油、パチョリ油、ヒドロキシシトロネラール、α−ピネン、ピペリトン、フェネチルアルコール、フェニルアセトアルデヒド、プチグレン油、ヘキシルシンナムアルデヒド、cis-3-ヘキセノール、ペルーバルサム、ベチバー油、ベチベロール、ペパーミント油、ペパー油、ヘリオトロピン、ベルガモット油、ベンジルベンゾエート、ボルネオール、ミルレジノイド、ムスクケトン、メチルノニルアセトアルデヒド、γ−メチルヨノン、メントール、L−メントール、L−メントン、ユーカリ油、β−ヨノン、ライム油、ラベンダー油、D−リモネン、リナロール、リラール、リリアール、レモン油、ローズアブソリュート、ローズオキシド、ローズ油、ローズマリー油、各種精油等の合成香料及び天然香料並びに各種調合香料が好ましいものとして挙げられる。 As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.
色素・着色剤・染料・顔料としては、褐色201号、黒色401号、紫色201号、紫色401号、青色1号、青色2号、青色201号、青色202号、青色203号、青色204号、青色205号、青色403号、青色404号、緑色201号、緑色202号、緑色204号、緑色205号、緑色3号、緑色401号、緑色402号、赤色102号、赤色104−1号、赤色105−1号、赤色106号、赤色2号、赤色201号、赤色202号、赤色203号、赤色204号、赤色205号、赤色206号、赤色207号、赤色208号、赤色213号、赤色214号、赤色215号、赤色218号、赤色219号、赤色220号、赤色221号、赤色223号、赤色225号、赤色226号、赤色227号、赤色228号、赤色230−1号、赤色230−2号、赤色231号、赤色232号、赤色3号、赤色401号、赤色404号、赤色405号、赤色501号、赤色502号、赤色503号、赤色504号、赤色505号、赤色506号、橙色201号、橙色203号、橙色204号、橙色205号、橙色206号、橙色207号、橙色401号、橙色402号、橙色403号、黄色201号、黄色202−1号、黄色202−2号、黄色203号、黄色204号、黄色205号、黄色4号、黄色401号、黄色402号、黄色403−1号、黄色404号、黄色405号、黄色406号、黄色407号、黄色5号等の法定色素;Acid Red 14等のその他酸性染料;Arianor Sienna Brown、Arianor Madder Red、Arianor Steel Blue、Arianor Straw Yellow等の塩基染料;HC Yellow 2、HC Yellow 5、HC Red 3、4-hydoxypropylamino-3-nitrophenol、N,N’-bis(2-hydroxyethyl)-2-nitro-p- phenylenediamine、HC Blue 2、Basic Blue 26等のニトロ染料;分散染料;二酸化チタン、酸化亜鉛等の無機白色顔料;酸化鉄(ベンガラ)、チタン酸鉄等の無機赤色系顔料;γ−酸化鉄等の無機褐色系顔料;黄酸化鉄、黄土等の無機黄色系顔料;黒酸化鉄、低次酸化チタン等の無機黒色系顔料;マンゴバイオレット、コバルトバイオレット等の無機紫色系顔料;酸化クロム、水酸化クロム、チタン酸コバルト等の無機緑色系顔料;群青、紺青等の無機青色系顔料;酸化チタンコーテッドマイカ、酸化チタンコーテッドオキシ塩化ビスマス、酸化チタンコーテッドタルク、着色酸化チタンコーテッドマイカ、オキシ塩化ビスマス、魚鱗箔等のパール顔料;アルミニウムパウダー、カッパーパウダー、金等の金属粉末顔料;表面処理無機及び金属粉末顔料;赤色201号、赤色202号、赤色204号、赤色205号、赤色220号、赤色226号、赤色228号、赤色405号、橙色203号、橙色204号、黄色205号、黄色401号、青色404号、赤色3号、赤色104号、赤色106号、赤色227号、赤色230号、赤色401号、赤色505号、橙色205号、黄色4号、黄色5号、黄色202号、黄色203号、緑色3号、青色1号等のジルコニウム、バリウム又はアルミニウムレーキ等の有機顔料;表面処理有機顔料;アスタキサンチン、アリザリン等のアントラキノン類、アントシアニジン、β−カロチン、カテナール、カプサンチン、カルコン、カルサミン、クエルセチン、クロシン、クロロフィル、クルクミン、コチニール、シコニン等のナフトキノン類、ビキシン、フラボン類、ベタシアニジン、ヘナ、ヘモグロビン、リコピン、リボフラビン、ルチン等の天然色素・染料;p−フェニレンジアミン、トルエン−2,5−ジアミン、o−,m−,若しくはp−アミノフェノール、m−フェニレンジアミン、5−アミノ−2−メチルフェノール、レゾルシン、1−ナフトール、2,6−ジアミノピリジン等及びその塩等の酸化染料中間体及びカップラー;インドリン等の自動酸化型染料;ジヒドロキシアセトンが好ましいものとして挙げられる。 As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Base dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4- Nitro dyes such as hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2 and Basic Blue 26; disperse dyes; inorganic white such as titanium dioxide and zinc oxide Pigments: Inorganic red pigments such as iron oxide (Bengara) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and loess; Black iron oxide, low-order titanium oxide, etc. Inorganic pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica; Titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil; aluminum powder, copper powder, gold, etc. Surface treated inorganic and metal powder pigments: Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204 No., Yellow 205, Yellow 401, Blue 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Organic pigments such as zirconium, barium or aluminum lake such as yellow 5, yellow 202, yellow 203, green 3 and blue 1; surface treatment organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene , Catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochini Natural pigments and dyes such as naphthoquinones such as ru and shikonin, bixin, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m- Oxidative dye intermediates and couplers such as p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; Oxidizing dyes; dihydroxyacetone is preferred.
水としては、常水、精製水の他、硬水、軟水、天然水、海洋深層水、電解アルカリイオン水、電解酸性イオン水、イオン水、クラスター水が好ましいものとして挙げられる。 Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.
これらの他、化粧品原料基準、化粧品種別配合成分規格、日本化粧品工業連合会成分表示名称リスト、INCI辞書(The International Cosmetic Ingredient Dictionary and Handbook)、医薬部外品原料規格、日本薬局方、医薬品添加物規格、食品添加物公定書等に記載されている成分、及び、国際特許分類IPCがA61K7及びA61K8の分類に属する日本国及び諸外国特許公報及び特許公開公報(公表公報・再公表を含む)に記載されている成分等、公知の化粧料成分、医薬品成分、食品成分などを、公知の組み合わせ及び配合比・配合量で含有させることが可能である。 In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.
本発明の化粧料又は皮膚外用剤の種類としては、毛髪用化粧料、基礎化粧料、メイクアップ化粧料、芳香化粧料、ボディ化粧料、軟膏等の皮膚外用剤等が挙げられる。本発明の効果を発揮させる観点から、特に毛髪用化粧料、基礎化粧料に好ましく使用することができる。本発明の化粧料は、通常の方法に従って製造することができる。 Examples of the cosmetic or skin external preparation of the present invention include skin external preparations such as hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and ointments. From the viewpoint of exerting the effects of the present invention, it can be preferably used particularly for hair cosmetics and basic cosmetics. The cosmetic of the present invention can be produced according to a usual method.
本発明の化粧料又は皮膚外用剤の種類をさらに詳細に説明すると、毛髪用化粧料としては、オイルシャンプー、クリームシャンプー、コンディショニングシャンプー、ふけ用シャンプー、ヘアカラー用シャンプー、リンス一体型シャンプー等のシャンプー;リンス、トリートメント、ヘアパック、ヘアフォーム、ヘアムース、ヘアスプレー、ヘアミスト、ヘアワックス、ヘアジェル、ウォーターグリース、セットローション、カラーローション、ヘアトニック、ヘアリキッド、ポマード、チック、ヘアクリーム、ヘアブロー、枝毛コート、ヘアオイル、パーマネントウェーブ用剤、ストレートパーマ剤、酸化染毛剤、ヘアブリーチ、ヘアカラープレトリートメント、ヘアカラーアフタートリートメント、パーマプレトリートメント、パーマアフタートリートメント、ヘアマニキュア、育毛剤が好ましいものとして挙げられる。 The cosmetic or skin external preparation of the present invention will be described in further detail. Examples of hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, and rinse-integrated shampoos. Rinsing, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow, split hair coat , Hair oil, permanent wave agent, straight permanent agent, oxidative hair dye, hair bleach, hair color pretreatment, hair color after treatment, permanent pretreatment, permare Terpolymers treatments, hair manicure, and as hair growth agents are preferred.
基礎化粧料としては、柔軟化粧水、収れん化粧水、洗浄用化粧水、多層式化粧水等の化粧水;エモリエントローション、モイスチャーローション、ミルキィーローション、ナリシングローション、ナリシングミルク、スキンモイスチャー、モイスャーエマルション、マッサージローション、クレンジングローション、プロテクトエマルション、サンプロテクト、サンプロテクター、UVケアミルク、サンスクリーン、メイクアップローション、角質スムーザー、エルボーローション、ハンドローション、ボディローション等の乳液;エモリエントクリーム、栄養クリーム、ナリシングクリーム、バニシングクリーム、モイスチャークリーム、ナイトクリーム、マッサージクリーム、クレンジングクリーム、メイクアップクリーム、ベースクリーム、プレメイクアップクリーム、サンスクリーンクリーム、サンタンクリーム、除毛クリーム、デオドラントクリーム、シェービングクリーム、角質軟化クリーム等のクリーム;モイスチャージェル等のジェル;保湿エッセンス、美白エッセンス、紫外線防止エッセンス等のエッセンス;リポソーム美容液、リポソーム化粧水等のリポソーム化粧品類;ピールオフパック、粉末パック、ウォッシングパック、オイルパック、クレンジングマスク等のパック・マスク類;クレンジングフォーム、クレンジングクリーム、クレンジングミルク、クレンジングローション、クレンジングジェル、クレンジングオイル、クレンジングマスク、洗粉、洗顔パウダー等の洗顔料;化粧石鹸、透明石鹸、薬用石鹸、液状石鹸、ひげそり石鹸、合成化粧石鹸等の石鹸が好ましいものとして挙げられる。 Basic cosmetics include soft lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, Nourishing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; Liposome cosmetics such as liposomal serum and liposome lotion; packs and masks such as peel-off pack, powder pack, washing pack, oil pack, cleansing mask; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing gel Facial cleansers such as oils, cleansing masks, powders and facial cleansers; cosmetic soaps, transparent soaps, medicated soaps, liquid soaps, shaving soaps, synthetic cosmetic soaps Soap can be mentioned as preferred.
メイクアップ化粧料としては、白粉・打粉類、ファンデーション類、口紅類、リップグロス、頬紅類、アイライナー、マスカラ、アイシャドー、眉墨、アイブロー、ネイルエナメル、エナメルリムーバー、ネイルトリートメントが好ましいものとして挙げられる。 As makeup cosmetics, white powder, dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment are preferable. .
芳香化粧料としては、香水、パフューム、パルファム、オードパルファム、オードトワレ、オーデコロン、練香水、芳香パウダー、香水石鹸、ボディローション、バスオイルが好ましいものとして挙げられる。 Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.
ボディ化粧料としては、ボディシャンプー等のボディ洗浄料、デオドラントローション、デオドラントパウダー、デオドラントスプレー、デオドラントスティック等の防臭化粧料、脱色剤、脱毛・除毛剤、浴用剤、虫よけスプレー等のインセクトリペラーが好ましいものとして挙げられる。 Body cosmetics include body shampoos and other body cleansers, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics, depigmenting agents, depilation / hair removal agents, bathing agents, insect repellents, etc. A repeller is preferred.
また、皮膚外用剤としては、軟膏剤、貼付剤、ローション剤、リニメント剤、液状塗布剤などの剤型で用いることができる。また、歯磨き、マウスウォッシュ等の口腔内化粧料としても用いることが出来る。 Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.
本発明の化粧料又は皮膚外用剤の剤型としては、水中油(O/W)型、油中水(W/O)型、W/O/W型、O/W/O型等の乳化型化粧料、油性化粧料、固形化粧料、液状化粧料、練状化粧料、スティック状化粧料、揮発性油型化粧料、粉状化粧料、ゼリー状化粧料、ジェル状化粧料、ペースト状化粧料、乳化高分子型化粧料、シート状化粧料、ミスト状化粧料、スプレー型化粧料等の剤型が好ましいものとして挙げられる。 As the dosage form of the cosmetic or external preparation for skin of the present invention, emulsification such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type, etc. Type cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, pastes Preferred examples include cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.
以下の実施例により、本発明を更に詳細に説明するが、本発明は、これらに何ら限定されるものではない。 The following examples further illustrate the present invention in detail but are not to be construed to limit the scope thereof.
複合体の製造
表1の組成でγ−オリザノールと水添大豆レシチンの合計10gをt−ブチルアルコール80gに溶解させた後、液体窒素にて瞬時に凍結し、凍結乾燥装置(東京理化器械製、FDU−2200型)にて凍結乾燥を行った。圧力は10Pa以下、トラップ温度は−80℃とした。このようにして得られた複合体は、いずれも均質な白色の粉末であった。なお、実施例1〜3は本発明の組成の範囲内の複合体であり、比較例1〜2は本発明の組成の範囲外の複合体、比較例3〜4は本発明の組成の範囲内の複合体であるが、水添大豆レシチンのPC純度が実施例とは異なる複合体である。
Manufacture of composites After a total of 10 g of γ-oryzanol and hydrogenated soybean lecithin was dissolved in 80 g of t-butyl alcohol with the composition shown in Table 1, it was immediately frozen in liquid nitrogen and freeze-dried (Tokyo Rika Kikai Co., Ltd., The product was freeze-dried with FDU-2200 type. The pressure was 10 Pa or less and the trap temperature was −80 ° C. The composites thus obtained were all homogeneous white powders. Examples 1-3 are composites within the range of the composition of the present invention, Comparative Examples 1-2 are composites outside the range of the composition of the present invention, and Comparative Examples 3-4 are ranges of the composition of the present invention. However, the PC purity of hydrogenated soybean lecithin is different from the examples.
水分散液の調製・評価
γ−オリザノールの配合量が水分散物に対して0.05重量%になるように、実施例1〜3の複合体を用いて表2の組成で水分散液を調製した(実施例4〜6)。また、同様に比較例1〜4の複合体を用いて表2の組成で水分散液を調製した(比較例5〜8)。得られた水分散液について、下記の方法で、初期分散性、透明感・透過率、分散安定性を評価し、結果は表2の下欄に併記した。
次に、γ−オリザノールの配合量が水分散物に対して0.1重量%になるように、実施例1〜3の複合体を用いて表3の組成で水分散液を調製した(実施例7〜9)。また、同様に比較例1〜4の複合体を用いて表3の組成で水分散液を調製した(比較例9〜12)。得られた水分散液について、下記の方法で、初期分散性、透明感・透過率、分散安定性を評価し、結果は表3の下欄に併記した。
<初期分散性>
得られた水分散液について、調製直後の分散状態を目視で観察し、下記の評価基準で初期分散性を評価した。
○・・・均一に分散されている
×・・・均一に分散されていない
<透明感・透過率>
得られた水分散液を直径3.5cmのガラス瓶に入れ、横から外観を目視で観察し、下記の評価基準で透明感を評価した。また、分光光度計を用いて水分散液の透過率を測定した(セル厚1cm、波長600nm)。
○・・・液の背後が透けて見える
×・・・液の背後が透けて見えない
<分散安定性>
得られた水分散液について、50℃/1ヵ月の保管安定性試験を行い、下記の評価基準で分散安定性を評価した。
○・・・保管後も均一に分散されている
×・・・保管後は均一に分散されていない、又は、沈殿が生じている
Preparation and Evaluation of Aqueous Dispersion Using the composites of Examples 1 to 3, the aqueous dispersion was prepared with the composition shown in Table 2 so that the amount of γ-oryzanol was 0.05% by weight based on the aqueous dispersion. Prepared (Examples 4-6). Similarly, aqueous dispersions having the compositions shown in Table 2 were prepared using the composites of Comparative Examples 1 to 4 (Comparative Examples 5 to 8). The obtained aqueous dispersion was evaluated for initial dispersibility, transparency / transmittance, and dispersion stability by the following methods, and the results are also shown in the lower column of Table 2.
Next, an aqueous dispersion was prepared with the composition shown in Table 3 using the composites of Examples 1 to 3 so that the blending amount of γ-oryzanol was 0.1% by weight with respect to the aqueous dispersion (implementation). Examples 7-9). Similarly, aqueous dispersions having the compositions shown in Table 3 were prepared using the composites of Comparative Examples 1 to 4 (Comparative Examples 9 to 12). The obtained aqueous dispersion was evaluated for initial dispersibility, transparency / transmittance, and dispersion stability by the following methods, and the results are also shown in the lower column of Table 3.
<Initial dispersibility>
About the obtained aqueous dispersion, the dispersion state immediately after preparation was observed visually, and initial dispersibility was evaluated according to the following evaluation criteria.
○ ・ ・ ・ Uniformly dispersed × ・ ・ ・ Not uniformly dispersed
<Transparency / Transparency>
The obtained aqueous dispersion was put in a glass bottle having a diameter of 3.5 cm, the appearance was visually observed from the side, and the transparency was evaluated according to the following evaluation criteria. Further, the transmittance of the aqueous dispersion was measured using a spectrophotometer (cell thickness: 1 cm, wavelength: 600 nm).
○ ... The back of the liquid can be seen through. × ... The back of the liquid cannot be seen through.
<Dispersion stability>
The obtained aqueous dispersion was subjected to a storage stability test at 50 ° C./month, and the dispersion stability was evaluated according to the following evaluation criteria.
○ ・ ・ ・ Uniformly dispersed after storage × ・ ・ ・ Not uniformly dispersed after storage or precipitation occurs
No.1〜2を70℃で攪拌し、均一に分散後、この液を予め約70℃でNo.3とNo.4を加温溶解させた水相に添加し、ホモミキサーにて攪拌(70℃、5000rpm、20分)した。
No. Nos. 1 and 2 were stirred at 70 ° C. and uniformly dispersed. 3 and no. 4 was added to the aqueous phase dissolved by heating, and stirred with a homomixer (70 ° C., 5000 rpm, 20 minutes).
No.1〜2を70℃で攪拌し、均一に分散後、この液を予め約70℃でNo.3とNo.4を加温溶解させた水相に添加し、ホモミキサーにて攪拌(70℃、5000rpm、20分)した。
No. Nos. 1 and 2 were stirred at 70 ° C. and uniformly dispersed. 3 and no. 4 was added to the aqueous phase dissolved by heating, and stirred with a homomixer (70 ° C., 5000 rpm, 20 minutes).
表2、3の結果より、本発明の複合体を用いて調製したγ−オリザノールを高濃度に含む水分散液は、初期分散性、透明感、分散安定性に優れるものであった。一方、複合体中のγ−オリザノール含有量が少ない比較例1の複合体は、初期分散性は良好なものの透明感がなく、分散安定性も不十分であった。複合体中のγ−オリザノール含有量が多い比較例2の複合体は、初期から分散性が不十分であった。また、比較例3、4の複合体を用いた水分散液も初期から分散性が不十分であり、γ−オリザノール含有量が本発明の範囲内であっても、レシチンのPC含量が異なると、分散性が不十分になることが示唆された。 From the results in Tables 2 and 3, the aqueous dispersion containing γ-oryzanol at a high concentration prepared using the composite of the present invention was excellent in initial dispersibility, transparency, and dispersion stability. On the other hand, the composite of Comparative Example 1 having a small content of γ-oryzanol in the composite had good initial dispersibility but no transparency and insufficient dispersion stability. The composite of Comparative Example 2 having a high γ-oryzanol content in the composite had insufficient dispersibility from the beginning. In addition, the aqueous dispersion using the composites of Comparative Examples 3 and 4 also has insufficient dispersibility from the beginning, and even if the γ-oryzanol content is within the scope of the present invention, the PC content of lecithin is different. It was suggested that the dispersibility becomes insufficient.
実施例10 美白化粧水
この化粧水は透明性、美白効果に優れ、肌を健やかに保ち、肌あれや乾燥による小ジワを防ぐことができる。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例1の複合体 0.5
グリセリン 8.0
B部
3−O−エチルアスコルビン酸(VCエチル:日本精化) 1.0
精製水 20.0
BG 5.0
エタノール 3.0
DPG 2.0
メチルグルセス−10 2.0
グリチルリチン酸2K 0.05
シロキクラゲ多糖体(Tremoist−TP:日本精化) 0.01
キサンタンガム 0.05
フェノキシエタノール 0.2
メチルパラベン 0.15
クエン酸 0.1
クエン酸Na pHが4.5になる量
C部
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
B部を混合し粘性な液を調製した。A部、C部を各70℃に加温し、C部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したB部を添加し、均一な液とした。
Example 10 Whitening lotion This lotion is excellent in transparency and whitening effect, keeps the skin healthy, and can prevent wrinkles due to rough skin and dryness.
Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 1 0.5
Glycerin 8.0
Part B 3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 1.0
Purified water 20.0
BG 5.0
Ethanol 3.0
DPG 2.0
Methyl Gluces-10 2.0
Glycyrrhizic acid 2K 0.05
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.01
Xanthan gum 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid 0.1
Amount of sodium citrate in which the pH is 4.5 Part C Purified water Amount in total of 100 ----------------------- ----------
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A and part C were each heated to 70 ° C., and part A was added while stirring part C with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part B mixed in advance was added to obtain a uniform liquid.
実施例11 美白化粧水
この化粧水は透明感があり、美白効果に優れ、肌を健やかに保ち、肌あれや乾燥による小ジワを防ぐことができる。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例3の複合体 0.3
グリセリン 6.0
B部
精製水 30.0
DPG 3.0
C部
トラネキサム酸(日本精化) 2.0
精製水 20.0
ナイアシンアミド 0.3
ベタイン 1.0
シクロヘキサンジカルボン酸ビスエトキシジグリコール
(Neosolue−Aqulio:日本精化) 0.5
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 11 Whitening lotion This lotion is transparent, has an excellent whitening effect, keeps the skin healthy, and prevents wrinkles caused by rough skin and dryness.
Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.3
Glycerin 6.0
Part B purified water 30.0
DPG 3.0
Part C Tranexamic acid (Nippon Seika) 2.0
Purified water 20.0
Niacinamide 0.3
Betaine 1.0
Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolu-Aquorio: Nippon Seika) 0.5
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例12 保湿化粧水
この化粧水は透明度の高い製剤であった。また、肌に潤いを与え、水分蒸散抑制によりみずみずしさを保ち、肌あれや乾燥による小ジワを防ぐ。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例2の複合体 0.3
ジグリセリン 3.0
グリセリン 8.0
B部
精製水 40.0
アルギニン 0.05
C部
シクロヘキサン-1,4-ジカルボン酸ビスエトキシジグリコール
(Neosolue−Aqulio:日本精化) 1.0
ベタイン 0.5
グリセレス−26 0.2
加水分解ヒアルロン酸 0.01
プルラン 0.5
ヒアルロン酸Na 0.01
ヒドロキシエチルセルロース 0.03
カルボキシビニルポリマー 0.05
アルギニン 0.05
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 12 Moisturizing lotion This lotion was a highly transparent preparation. It also moisturizes the skin, keeps it fresh by suppressing moisture transpiration, and prevents wrinkles caused by dry skin and dryness.
Component Blending amount (% by weight)
--------------------------------------
Part A Composite of Example 2 0.3
Diglycerin 3.0
Glycerin 8.0
Part B purified water 40.0
Arginine 0.05
Part C Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (Neosolu-Aculio: Nippon Seika) 1.0
Betaine 0.5
Glyceres-26 0.2
Hydrolyzed hyaluronic acid 0.01
Pullulan 0.5
Hyaluronic acid Na 0.01
Hydroxyethyl cellulose 0.03
Carboxyvinyl polymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例13 保湿化粧水
この化粧水は透明性が高く、保湿効果に優れ、肌に潤いを与え、みずみずしさを保ち、肌あれや乾燥による小ジワを防ぐ。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例3の複合体 0.25
水添レシチン、フィトステロールズ、セラミド2、セラミド3、セラミド6
(Phytopresome−Cera236:日本精化) 0.1
糖脂質、水添レシチン、BG、グリセリン
(Phytopresome−MEL:日本精化) 0.8
BG 5.0
グリセリン 12.0
イノシト−ル 1.0
B部
精製水 20.0
C部
(エイコサン二酸/テトラデカン二酸)ポリグリセリル−10
(Neosolue−AquaS:日本精化) 1.0
PEG/PPG/ポリブチレングリコール−8/5/3グリセリン 0.5
グルコシルセラミド 0.5
グルコシルトレハロース 0.5
ポリクオタニウム−51 0.5
アセチルヘキサペプチド−8 0.001
加水分解コラーゲン 0.05
EDTA−2Na 0.05
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 13 Moisturizing lotion This lotion is highly transparent, has an excellent moisturizing effect, moisturizes the skin, keeps it fresh, and prevents wrinkles due to dry skin and dryness.
Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.25
Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6
(Phytopresome-Cera236: Nippon Seika) 0.1
Glycolipid, hydrogenated lecithin, BG, glycerin (Phytopresome-MEL: Nippon Seika) 0.8
BG 5.0
Glycerin 12.0
Inositol 1.0
Part B purified water 20.0
Part C (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10
(Neosol-AquaS: Nippon Seika) 1.0
PEG / PPG / polybutylene glycol-8 / 5/3 glycerol 0.5
Glucosylceramide 0.5
Glucosyl trehalose 0.5
Polyquaternium-51 0.5
Acetyl hexapeptide-8 0.001
Hydrolyzed collagen 0.05
EDTA-2Na 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例14 浸透化粧水
この化粧水は肌への浸透感があり、潤い、みずみずしさを保ち、肌あれや乾燥による小ジワを防ぐ。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例3の複合体 0.7
オレイン酸オレイル 0.03
グリセリン 10.0
B部
グルコース 1.0
DPG 3.0
ココイルアルギニンエチルPCA 0.05
ポリリジン 0.05
トリプロピレングリコール 1.0
精製水 20.0
C部
フェノキシエタノール 0.3
プルラン 0.2
エチルヘキシルグリセリン 0.2
アセチルグルコサミン 0.03
ポリHEMAグルコシド 0.05
ポリメタクリロイルリシン 0.05
結晶セルロース末 0.1
ローカストビーンガム 0.03
キトサン 0.05
ヒドロキシエチルセルロース 0.05
ヒアルロン酸Na 0.01
カルボマー 0.06
水酸化K 0.03
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部を約70℃に加温し、均一に分散させた。C部を混合、よく攪拌し、均一にしたのち約70℃に加温した。B部をプロペラで攪拌しナノベシクル液を調製した。A部にC部を加え、約70℃でホモミキサーを用い撹拌し、約40℃まで冷却し、B部の混合液を添加した。
Example 14 Osmotic Toner Lotion This skin lotion has a sense of penetration into the skin, keeps it moist and fresh, and prevents wrinkles due to skin dryness and dryness.
Component Blending amount (% by weight)
-----------------------------------
Part A Composite of Example 3 0.7
Oleyl oleate 0.03
Glycerin 10.0
Part B Glucose 1.0
DPG 3.0
Cocoyl Arginine Ethyl PCA 0.05
Polylysine 0.05
Tripropylene glycol 1.0
Purified water 20.0
Part C Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexyl glycerin 0.2
Acetylglucosamine 0.03
Poly HEMA glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Chitosan 0.05
Hydroxyethyl cellulose 0.05
Hyaluronic acid Na 0.01
Carbomer 0.06
Hydroxide K 0.03
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dispersed uniformly. Part C was mixed, stirred well, homogenized, and heated to about 70 ° C. Part B was stirred with a propeller to prepare a nano vesicle solution. C part was added to A part, it stirred using the homomixer at about 70 degreeC, it cooled to about 40 degreeC, and the liquid mixture of B part was added.
実施例15 ジェル化粧水
この化粧水は肌への浸透感があり、潤い、みずみずしさを保ち、肌あれや乾燥による小ジワを防ぐ。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例3の複合体 0.25
グリセリン 10.0
ソルビトール液(70%) 5.0
PEG−10ジメチコン 0.4
B部
グルコース 1.0
DPG 3.0
トリプロピレングリコール 1.0
精製水 20.0
C部
フェノキシエタノール 0.3
プルラン 0.2
エチルヘキシルグリセリン 0.2
ポリHEMAグルコシド 0.05
ポリメタクリロイルリシン 0.05
結晶セルロース末 0.1
ローカストビーンガム 0.03
ヒドロキシエチルセルロース 0.05
カラギーナン 0.05
ヒアルロン酸Na 0.01
カルボマー 0.06
水酸化K 0.05
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部を約70℃に加温し、均一に分散させた。C部を混合、よく攪拌し、均一にしたのち約70℃に加温した。B部をプロペラで攪拌しナノベシクル液を調製した。A部にC部を加え、約70℃でホモミキサーを用い撹拌し、約40℃まで冷却し、B部の混合液を添加した。
Example 15 Gel lotion This skin lotion has a feeling of penetrating into the skin, keeps it moist and fresh, and prevents wrinkles due to skin dryness and dryness.
Component Blending amount (% by weight)
-----------------------------------
Part A Composite of Example 3 0.25
Glycerin 10.0
Sorbitol solution (70%) 5.0
PEG-10 Dimethicone 0.4
Part B Glucose 1.0
DPG 3.0
Tripropylene glycol 1.0
Purified water 20.0
Part C Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexyl glycerin 0.2
Poly HEMA glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Carrageenan 0.05
Hyaluronic acid Na 0.01
Carbomer 0.06
Hydroxide K 0.05
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dispersed uniformly. Part C was mixed, stirred well, homogenized, and heated to about 70 ° C. Part B was stirred with a propeller to prepare a nano vesicle solution. C part was added to A part, it stirred using the homomixer at about 70 degreeC, it cooled to about 40 degreeC, and the liquid mixture of B part was added.
実施例16 保湿化粧水
この化粧水は透明性が高く、保湿効果に優れ、肌に潤いを与え、みずみずしさを保ち、肌あれや乾燥による小ジワを防ぐ。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例1の複合体 0.9
グリセリン 6.0
PEG−50水添ヒマシ油 0.3
ラウリン酸ポリグリセリル−10 0.2
マカデミアナッツ油脂肪酸フィトステリル
(Plandool−MAS:日本精化) 0.05
B部
精製水 20.0
C部
ポリクオタニウム−51 0.5
アセチルヘキサペプチド−8 0.001
加水分解コラーゲン 0.05
EDTA−2Na 0.05
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 16 Moisturizing lotion This lotion is highly transparent, excellent in moisturizing effect, moisturizes the skin, keeps it fresh, and prevents wrinkles due to skin dryness and dryness.
Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 1 0.9
Glycerin 6.0
PEG-50 hydrogenated castor oil 0.3
Polyglyceryl laurate-10 0.2
Macadamia nut oil fatty acid phytosteryl (Plandool-MAS: Nippon Seika) 0.05
Part B purified water 20.0
Part C Polyquaternium-51 0.5
Acetyl hexapeptide-8 0.001
Hydrolyzed collagen 0.05
EDTA-2Na 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例17 保湿化粧水
この化粧水は透明性が高く、保湿効果に優れ、肌に潤いを与え、みずみずしさを保ち、肌あれや乾燥による小ジワを防ぐ。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例3の複合体 0.2
グリセリン 8.0
リゾレシチン 0.03
環状リゾフォスファチジン酸Na 0.001
B部
精製水 20.0
C部
加水分解コラーゲン 0.05
クエン酸 0.01
クエン酸Na 0.09
EDTA−2Na 0.05
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をプロペラ(500rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 17 Moisturizing lotion This lotion is highly transparent, has an excellent moisturizing effect, moisturizes the skin, keeps it fresh, and prevents wrinkles due to skin dryness and dryness.
Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.2
Glycerin 8.0
Lysolecithin 0.03
Cyclic lysophosphatidic acid Na 0.001
Part B purified water 20.0
Part C Hydrolyzed collagen 0.05
Citric acid 0.01
Na citrate 0.09
EDTA-2Na 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例18 透明ジェル
このジェルは、肌への浸透感があるものであった。また肌の潤い、みずみずしさを保ち、肌あれや乾燥による小ジワを防ぐ。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例2の複合体 0.4
グリセリン 5.0
PPG−6デシルテトラデセス−30 0.2
PEG−30フィトステロール 0.3
Phytopresome−MEL(日本精化) 0.8
精製水 30.0
B部
PEG−4000 0.2
メチルグルセス−10 1.0
ピリドキシン塩酸塩 0.05
エチルヘキシルグリセリン 0.2
フェノキシエタノール 0.4
環状リゾフォスファチジン酸Na 0.001
シロキクラゲ多糖体(Tremoist−TP:日本精化) 0.01
加水分解コラーゲン 0.01
精製水 合計で100となる量
C部
ペンテト酸5Na 0.05
(アクリル酸ジメチルタウリンアンモニウム/ビニルピロリドン)コポリマー0.05
(アクリレーツ/アクリル酸アルキル(C10-30))クロスポリマー 0.15
アルギニン 0.25
精製水 30.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部をプロペラで攪拌しナノベシクル液を調製した。C部を混合時、粘性の液とした。B部を混合し、均一な液とした。C部にA部、B部を加え均一にした。
Example 18 Transparent Gel This gel had a sense of penetration into the skin. It also keeps the skin moist and fresh and prevents fine wrinkles due to skin dryness and dryness.
Component Blending amount (% by weight)
--------------------------------------
Part A Composite of Example 2 0.4
Glycerin 5.0
PPG-6 decyltetradeces-30 0.2
PEG-30 phytosterol 0.3
Phytopresome-MEL (Nippon Seika) 0.8
Purified water 30.0
Part B PEG-4000 0.2
Methyl Gluces-10 1.0
Pyridoxine hydrochloride 0.05
Ethylhexyl glycerin 0.2
Phenoxyethanol 0.4
Cyclic lysophosphatidic acid Na 0.001
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.01
Hydrolyzed collagen 0.01
Purified water Amount of part C totaling 100 parts Pentate acid 5Na 0.05
(Ammonium dimethyltaurate acrylate / vinylpyrrolidone) Copolymer 0.05
(Acrylates / alkyl acrylate (C10-30)) cross polymer 0.15
Arginine 0.25
Purified water 30.0
---------------------------------------
(Preparation method)
Part A was stirred with a propeller to prepare a nano vesicle solution. Part C was a viscous liquid when mixed. Part B was mixed to obtain a uniform liquid. Part A and part B were added to part C to make it uniform.
実施例19 保湿化粧水
この化粧水は透明度の高い製剤であり、肌に潤いを与え、水分蒸散抑制によりみずみずしさを保ち、肌あれや乾燥による小ジワを防ぐ。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例3の複合体 0.3
ジグリセリン 3.0
グリセリン 8.0
B部
精製水 20.0
アルギニン 0.05
C部
(エイコサン二酸/テトラデカン二酸)ポリグリセリル−10
(Neosolue−AquaS:日本精化) 1.0
ベタイン 0.5
ポリリジン 0.01
加水分解ヒアルロン酸 0.01
プルラン 0.5
ヒアルロン酸Na 0.01
ヒドロキシエチルセルロース 0.03
キトサン 0.02
カルボキシビニルポリマー 0.05
アルギニン 0.05
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 19 Moisturizing lotion This lotion is a highly transparent preparation, moisturizes the skin, keeps it fresh by inhibiting moisture transpiration, and prevents wrinkles due to skin dryness and dryness.
Component Blending amount (% by weight)
--------------------------------------
Part A Composite of Example 3 0.3
Diglycerin 3.0
Glycerin 8.0
Part B purified water 20.0
Arginine 0.05
Part C (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10
(Neosol-AquaS: Nippon Seika) 1.0
Betaine 0.5
Polylysine 0.01
Hydrolyzed hyaluronic acid 0.01
Pullulan 0.5
Hyaluronic acid Na 0.01
Hydroxyethyl cellulose 0.03
Chitosan 0.02
Carboxyvinyl polymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例20 保湿化粧水
この化粧水は透明度の高い製剤であった。また、肌に潤いを与え、水分蒸散抑制によりみずみずしさを保ち、肌あれや乾燥による小ジワを防ぐ。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例2の複合体 0.8
ジグリセリン 1.0
グリセリン 8.0
ラウロイルグルタミン酸ジ(フィトステリル/オクチルドデシル)
(Plandool−LG2:日本精化) 0.1
イソステアリン酸フィトステリル
(Plandool−ISS:日本精化) 0.05
ポリソルベート20 0.3
B部
精製水 30.0
C部
マルチトール液 1.0
ベタイン 0.5
α−グルカンオリゴサッカリド 0.1
プルラン 0.5
チューベロース多糖体 0.01
ヒドロキシプロピルメチルセルロースステアロキシエーテル 0.05
(アクリレーツ/アクリル酸アルキル(C10−30))クロスポリマー 0.05
アルギニン 0.05
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに高圧乳化機(みずほ工業製マイクロフルイダイザー)にて分散させた。冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 20 Moisturizing lotion This lotion was a highly transparent preparation. It also moisturizes the skin, keeps it fresh by suppressing moisture transpiration, and prevents wrinkles caused by dry skin and dryness.
Component Blending amount (% by weight)
--------------------------------------
Part A Composite of Example 2 0.8
Diglycerin 1.0
Glycerin 8.0
Lauroyl glutamate di (phytosteryl / octyldodecyl)
(Plandool-LG2: Nippon Seika) 0.1
Phytosteryl isostearate (Plandool-ISS: Nippon Seika) 0.05
Polysorbate 20 0.3
Part B purified water 30.0
Part C Maltitol solution 1.0
Betaine 0.5
α-glucan oligosaccharide 0.1
Pullulan 0.5
Tuberose polysaccharide 0.01
Hydroxypropyl methylcellulose stearoxy ether 0.05
(Acrylates / alkyl acrylate (C10-30)) Crosspolymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, the mixture was dispersed with a high-pressure emulsifier (Microfluidizer manufactured by Mizuho Industries). After cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例21 保湿化粧水
この化粧水は透明度の高い製剤であった。また、肌に潤いを与え、水分蒸散抑制によりみずみずしさを保ち、肌あれや乾燥による小ジワを防ぐ。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例3の複合体 0.2
ジグリセリン 1.0
グリセリン 8.0
ダイマージリノール酸ジ(イソステアリル/フィトステリル)
(LUSPLAN PI−DA:日本精化) 0.05
ビスジグリセリルポリアシルアジペート−2
(Plandool−DP:日本精化) 0.05
B部
精製水 30.0
C部
マンニトール 1.0
PEG−30 1.0
加水分解コラーゲン 0.1
プルラン 0.5
Tremoist−TP(日本精化) 0.01
ヒドロキシエチルセルロース 0.03
カルボキシビニルポリマー 0.05
アルギニン 0.05
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに高圧乳化機(みずほ工業製マイクロフルイダイザー)にて分散させた。冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 21 Moisturizing lotion This lotion was a highly transparent preparation. It also moisturizes the skin, keeps it fresh by suppressing moisture transpiration, and prevents wrinkles caused by dry skin and dryness.
Component Blending amount (% by weight)
--------------------------------------
Part A Composite of Example 3 0.2
Diglycerin 1.0
Glycerin 8.0
Dimer dilinoleic acid di (isostearyl / phytosteryl)
(LUSPLAN PI-DA: Nippon Seika) 0.05
Bisdiglyceryl polyacyl adipate-2
(Plandool-DP: Nippon Seika) 0.05
Part B purified water 30.0
Part C Mannitol 1.0
PEG-30 1.0
Hydrolyzed collagen 0.1
Pullulan 0.5
Tremoist-TP (Nippon Seika) 0.01
Hydroxyethyl cellulose 0.03
Carboxyvinyl polymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, the mixture was dispersed with a high-pressure emulsifier (Microfluidizer manufactured by Mizuho Industries). After cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例22 スカルプローション
このローションは透明度の高い製剤であり、頭皮を柔軟にし、頭皮のべたつきやカサつきなどの改善が可能である。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例3の複合体 0.3
グリセリン 4.0
ペンチレングリコール 2.0
マルチトール液 0.5
B部
精製水 50.0
C部
エタノール 10.0
Neosolue−Aqulio(日本精化) 1.0
酢酸トコフェロール 0.05
メントール 0.1
メントキシプロパンジオール 0.05
ベタイン 0.2
ヒドロキシプロピルキトサン液 0.05
ニンジンエキス 0.1
センブリエキス 0.1
タマサキツヅラフジ根エキス 0.003
ピリドキシン塩酸塩 0.05
パンテノール 0.1
PCA−Na 0.1
ペンテト酸5Na 0.05
メチルパラベン 0.1
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 22 Scalp Lotion This lotion is a highly transparent preparation, which can soften the scalp and improve the stickiness and roughness of the scalp.
Component Blending amount (% by weight)
------------------------------------
Part A Composite of Example 3 0.3
Glycerin 4.0
Pentylene glycol 2.0
Maltitol 0.5
Part B purified water 50.0
Part C ethanol 10.0
Neosolu-Aquilio (Nippon Seika) 1.0
Tocopherol acetate 0.05
Menthol 0.1
Menthoxypropanediol 0.05
Betaine 0.2
Hydroxypropyl chitosan solution 0.05
Carrot extract 0.1
Assembly extract 0.1
Japanese cypress rafji root extract 0.003
Pyridoxine hydrochloride 0.05
Panthenol 0.1
PCA-Na 0.1
Penteto acid 5Na 0.05
Methylparaben 0.1
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例23 スカルプローション
このローションは透明度の高い製剤であり、頭皮を柔軟にし、頭皮のべたつきやカサつきなどの改善が可能である。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
実施例1の複合体 0.3
ペンチレングリコール 2.0
PEG−60水添ヒマシ油 0.3
B部
精製水 50.0
C部
Neosolue−Aqulio(日本精化) 1.0
Tremoist−TP(日本精化) 0.01
ピリドキシン塩酸塩 0.05
リンゴ酸 0.01
カキタンニン 0.005
無水カフェイン 0.001
加水分解コラーゲン 0.05
ペンテト酸5Na 0.05
メチルパラベン 0.1
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 23 Skull Lotion This lotion is a highly transparent preparation, which can soften the scalp and improve the stickiness and roughness of the scalp.
Component Blending amount (% by weight)
------------------------------------
Part A Complex of Example 1 0.3
Pentylene glycol 2.0
PEG-60 hydrogenated castor oil 0.3
Part B purified water 50.0
Part C Neosolue-Aculio (Nippon Seika) 1.0
Tremoist-TP (Nippon Seika) 0.01
Pyridoxine hydrochloride 0.05
Malic acid 0.01
Oyster tannin 0.005
Anhydrous caffeine 0.001
Hydrolyzed collagen 0.05
Penteto acid 5Na 0.05
Methylparaben 0.1
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例24 スカルプローション
このローションは透明度が高く、保湿感と浸透感に優れ、頭皮の状態を改善し、べたつきやカサつきを抑制できる。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
グリセリン 6.0
実施例3の複合体 0.3
B部
Neosolue−AquaS(日本精化) 0.5
ラフィノース 0.2
アルギニン 0.5
グリシン 0.1
精製水 50.0
C部
エタノール 5.0
メチルパラベン 0.1
メントキシプロパンジオール 0.1
ジカルボエトキシパントテン酸エチル 0.2
カンファー 0.1
ニンジンエキス 1.0
グリコシルトレハロース 0.5
ニコチン酸アミド 1.0
グリチルリチン酸ジカリウム 0.1
VCエチル(日本精化) 0.3
ヒアルロン酸Na 0.01
Tremoist−SL(日本精化) 0.5
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をプロペラ(500rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 24 Scalp Lotion This lotion has high transparency, excellent moisturizing and penetrating feeling, improves the condition of the scalp, and can suppress stickiness and rustiness.
Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 6.0
Complex of Example 3 0.3
Part B Neosolute-AquaS (Japan Seika) 0.5
Raffinose 0.2
Arginine 0.5
Glycine 0.1
Purified water 50.0
Part C Ethanol 5.0
Methylparaben 0.1
Menthoxypropanediol 0.1
Ethyl dicarboethoxy pantothenate 0.2
Camphor 0.1
Carrot extract 1.0
Glycosyl trehalose 0.5
Nicotinamide 1.0
Dipotassium glycyrrhizinate 0.1
VC ethyl (Nippon Seika) 0.3
Hyaluronic acid Na 0.01
Tremoist-SL (Nippon Seika) 0.5
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例25 育毛剤
この育毛剤は透明度が高く、保湿感と浸透感に優れ、頭皮の状態を改善し、べたつきやカサつきを抑制できる製剤であった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
グリセリン 2.0
実施例2の複合体 0.5
PEG−60水添ヒマシ油 0.3
B部
ベタイン 0.5
精製水 50.0
C部
エタノール 20.0
メントキシプロパンジオール 0.1
オレンジ油 0.05
パンテニルエチルエ−テル 0.2
グルタミン酸 0.1
ポリ塩化ジメチルメチレンピペリジニウム液 0.1
ニンジンエキス 5.0
センブリエキス 1.0
トレハロース 0.5
ニコチン酸アミド 1.0
ピロクトンオラミン 0.1
グリチルリチン酸ジカリウム 0.1
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をホモミキサー(7000rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 25 Hair Growth Agent This hair growth agent was a preparation that was highly transparent, excellent in moisturizing feeling and penetrating feeling, improved the state of the scalp, and suppressed stickiness and roughness.
Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 2.0
Complex of Example 2 0.5
PEG-60 hydrogenated castor oil 0.3
Part B Betaine 0.5
Purified water 50.0
Part C ethanol 20.0
Menthoxypropanediol 0.1
Orange oil 0.05
Panthenyl ethyl ether 0.2
Glutamic acid 0.1
Polydimethyldimethylmethylenepiperidinium solution 0.1
Carrot extract 5.0
Assembly extract 1.0
Trehalose 0.5
Nicotinamide 1.0
Piroctone olamine 0.1
Dipotassium glycyrrhizinate 0.1
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
実施例26 育毛剤
この育毛剤は透明度が高く、保湿感と浸透感に優れ、頭皮の状態を改善し、育毛効果が期待できる製剤であった。
成 分 配合量(重量%)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
A部
グリセリン 4.0
BG 3.0
実施例3の複合体 0.1
Phytopresome−MEL(日本精化) 1.0
B部
Neosolue−Aqulio(日本精化) 0.5
DPG 2.0
乳酸 0.1
Tremoist−TP(日本精化) 0.01
精製水 50.0
C部
エタノール 10.0
メントール 0.1
メンチルグリセリルエーテル 0.15
パンテニルエチルエ−テル 0.2
カンファー 0.1
冬虫夏草エキス 1.0
センブリエキス 1.0
加水分解ヒアルロン酸 0.02
環状リゾフォスファチジン酸Na 0.001
トウガラシエキス 0.01
ベタイン 0.3
トレハロース 0.2
シメン−5−オール 0.1
酢酸トコフェロール 0.05
β−グリチルレチン酸 0.05
精製水 合計で100となる量
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(調製方法)
A部、B部を各70℃に加温し、B部をプロペラ(500rpm)で攪拌しながらA部を加え、ナノベシクル液を調製した。さらに冷却後あらかじめ混合したC部を添加し、均一な液とした。
Example 26 Hair Growth Agent This hair growth agent was a formulation with high transparency, excellent moisturizing feeling and penetrating feeling, improved scalp condition, and expected hair growth effect.
Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 4.0
BG 3.0
Complex of Example 3 0.1
Phytopresome-MEL (Nippon Seika) 1.0
Part B Neosolu-Aquorio (Nippon Seika) 0.5
DPG 2.0
Lactic acid 0.1
Tremoist-TP (Nippon Seika) 0.01
Purified water 50.0
Part C ethanol 10.0
Menthol 0.1
Menthyl glyceryl ether 0.15
Panthenyl ethyl ether 0.2
Camphor 0.1
Cordyceps extract 1.0
Assembly extract 1.0
Hydrolyzed hyaluronic acid 0.02
Cyclic lysophosphatidic acid Na 0.001
Pepper extract 0.01
Betaine 0.3
Trehalose 0.2
Cymene-5-ol 0.1
Tocopherol acetate 0.05
β-glycyrrhetinic acid 0.05
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.
Claims (3)
(A)γ−オリザノール
(B)リン脂質
が有機溶媒中に均一に溶解している溶液から有機溶媒を除去して、成分(A)(B)を同時に析出せしめて得られる乳化又は可溶化組成物の調製に使用される化粧料又は皮膚外用剤用のγ−オリザノール−リン脂質複合体において、(A)の含有量が20〜40重量%、(B)の含有量が60〜80重量%であることを特徴とする複合体。 The following components (A) and (B);
(A) An emulsified or solubilized composition obtained by removing an organic solvent from a solution in which γ-oryzanol (B) phospholipid is uniformly dissolved in the organic solvent and simultaneously depositing the components (A) and (B) In the γ-oryzanol-phospholipid complex for cosmetics or skin external preparations used for the preparation of products, the content of (A) is 20 to 40% by weight, and the content of (B) is 60 to 80% by weight A complex characterized in that
A cosmetic or external preparation for skin comprising the complex according to claim 1 or 2.
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JP2019099566A (en) * | 2017-11-29 | 2019-06-24 | サンスター株式会社 | Skin lotion composition |
JP2019131547A (en) * | 2018-01-31 | 2019-08-08 | 株式会社コーセー | Aqueous composition |
JP2020010678A (en) * | 2018-07-10 | 2020-01-23 | 富士フイルム株式会社 | Skin-whitening agent screening method, preparation, and fiber formation inhibitor |
WO2020149162A1 (en) * | 2019-01-16 | 2020-07-23 | 株式会社 資生堂 | Lecithin-containing cosmetic base material and cosmetic preparation in which same is blended |
CN112843006A (en) * | 2021-01-28 | 2021-05-28 | 上海嘉申医药研发有限公司 | Oryzanol phospholipid complex and preparation method and application thereof |
CN112870168A (en) * | 2021-01-28 | 2021-06-01 | 上海嘉申医药研发有限公司 | Oryzanol phospholipid complex solid dispersion as well as preparation method and application thereof |
CN113226277A (en) * | 2018-12-26 | 2021-08-06 | 日本精化株式会社 | Whitening agent, hyaluronic acid production promoter, collagen production promoter, intracellular active oxygen scavenger, irritation relieving agent, wrinkle improving agent, complex, cosmetic and skin external preparation |
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US20220110850A1 (en) * | 2019-01-16 | 2022-04-14 | Shiseido Company, Ltd. | Lecithin-containing cosmetic base material and cosmetic preparation in which same is blended |
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