JP2018087148A - COSMETIC CONTAINING γ-ORYZANOL - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a complex in which γ-oryzanol can be blended into aqueous formulation simply and at high concentration, and by which emulsified or solubilized composition having transparency of external appearance and high dispersion stability is obtained.SOLUTION: There is provided a γ-oryzanol-phospholipid complex which is obtained by removing organic solvent from solution in which component (A) γ-oryzanol and component (B) phospholipid are homogeneously dissolved in organic solvent and precipitating sparingly water-soluble physiologically active substance and phospholipid simultaneously, in which the content of component (A) is 20 to 40 wt.%, and the content of component (B) is 60 to 80 wt.%.SELECTED DRAWING: None

Description

  The present invention relates to a γ-oryzanol-phospholipid obtained by removing an organic solvent from a solution in which γ-oryzanol and phospholipid are uniformly dissolved in an organic solvent, and simultaneously depositing γ-oryzanol and phospholipid. Concerning the complex.

  γ-Oryzanol has long been used as an active ingredient in pharmaceuticals, foods and cosmetics. The action of γ-oryzanol on the living body is various, and as actions on the skin, for example, antioxidant, ultraviolet absorption, blood flow promotion, tyrosinase activity suppression, sebaceous gland activation, etc. are known, and depending on the purpose It is blended in cosmetics or skin external preparations. However, γ-oryzanol is a poorly water-soluble compound, and in order to incorporate these into a water-based formulation at a high concentration, it is first dissolved in fats and oils and then emulsified in an aqueous phase using a surfactant. A method is used (for example, Patent Document 1). However, there are concerns about the safety of the surfactants used and skin irritation, and a prescription without these concerns has been desired.

  Phospholipids are known as surfactants that do not have safety and skin irritation concerns. Phospholipids are the main components that form biological cell membranes, are extremely safe for humans, and are not irritating to the skin. Therefore, phospholipids are widely used in pharmaceuticals, foods, cosmetics, and the like. However, phospholipids have properties such as poor solubility in oils and poor initial hydration properties. For the preparation of emulsified or solubilized compositions using phospholipids, vigorous stirring is performed using a special apparatus. Complicated work such as mixing is required. Moreover, it cannot be said that the dispersion stability of the emulsified or solubilized composition obtained by such a method is sufficient.

  In Patent Document 2, the organic solvent is removed from the solution in which the poorly water-soluble physiologically active substance and phospholipid are uniformly dissolved in the organic solvent, and the poorly water-soluble physiologically active substance and phospholipid are simultaneously deposited. A sparingly water-soluble physiologically active substance-phospholipid complex obtained is disclosed, and by using the complex, a sparingly water-soluble physiologically active substance can be easily emulsified or solubilized using phospholipid. It is described that the dispersion stability of the resulting composition is also good. Patent Document 2 discloses a complex (Production Example 3) composed of 10% by weight of γ-oryzanol and 90% by weight of phospholipid, and an aqueous dispersion containing this complex at a concentration of 0.2% by weight ( Example 3, 0.02% by weight as the concentration of γ-oryzanol) is disclosed, and it is disclosed that this dispersion is excellent in stability (Tables 1 and 2). However, in order to further exhibit the effects and efficacy of γ-oryzanol, it is desired to add γ-oryzanol to an aqueous formulation at a higher concentration.

JP 2008-120748 A JP 2007-197328 A JP-A-4-149194

  The inventors of the present invention use various composites (Production Example 3) of Patent Document 2 for the purpose of preparing an emulsified or solubilized composition containing γ-oryzanol at a high concentration using phospholipids. When examined, increasing the blending amount of the complex to the emulsified or solubilized composition in order to blend γ-oryzanol at a high concentration, the transparency of the resulting emulsified or solubilized composition is lost, and It was found that the dispersion stability was insufficient. Accordingly, an object of the present invention is to provide a composite in which γ-oryzanol can be easily emulsified or solubilized at a high concentration, and an emulsified or solubilized composition having a transparent appearance and good dispersion stability can be obtained. To provide a body.

  As a result of intensive studies to solve the above problems, the present inventors have determined that an organic solvent is removed from a solution in which the component (A) γ-oryzanol and the component (B) phospholipid are uniformly dissolved in the organic solvent. The γ-oryzanol-phospholipid complex obtained by removing and simultaneously depositing γ-oryzanol and phospholipid, the content of component (A) is 20-40%, the content of component (B) is 60- It was found that the above-mentioned problems can be solved by using a composite characterized by 80%, and the present invention was completed.

  By using the complex of the present invention, γ-oryzanol can be easily emulsified or solubilized in water at a high concentration. Moreover, the emulsified or solubilized composition obtained has a transparent appearance and its dispersion stability is good.

  The composite as used in the present invention refers to a composite that exhibits one physicochemical property as a composite while a mixture of a plurality of substances maintains individual chemical properties. For example, the behavior with respect to temperature changes due to the composite, and the solubility and dispersibility in a solvent change.

  The complex of the present invention can be obtained by removing the organic solvent from a solution in which γ-oryzanol and phospholipid are uniformly dissolved in the organic solvent, and simultaneously depositing γ-oryzanol and phospholipid.

  The method for producing the composite of the present invention is as follows. First, γ-oryzanol and phospholipid are uniformly dissolved or dispersed in an organic solvent. At this time, it can be carried out efficiently by using means such as heating and stirring. Next, the organic solvent is removed from the organic solvent solution to precipitate γ-oryzanol and phospholipid simultaneously. As this method, for example, the organic solvent solution is heated or / and the organic solvent is distilled off under reduced pressure, the organic solvent solution is spray-dried, or the organic solvent is instantly frozen with liquid nitrogen or the like. Thereafter, a method of freeze-drying and the like can be mentioned. Although the target complex can be obtained in a semi-solid, solid, or powder state by such a method, it is preferably obtained in a powder form from the viewpoint of the swelling speed when dispersed in water. From this, it is preferable to use spray drying and freeze drying as the production method. Further, as the spray drying, the organic solvent solution is supplied to the tubular heater at a constant rate, and the organic solvent is heated in the heater. It is most preferable to use a device that instantaneously evaporates the organic solvent (instantaneous vacuum dryer) by evaporating the mixture into a mixture of substantially solids and vapor of the organic solvent, and introducing the mixture into the vacuum chamber at high speed. preferable. Details of this apparatus are described in Patent Document 3.

  The organic solvent used in the production of the composite of the present invention is not particularly limited as long as it can uniformly dissolve or disperse all components to be complexed. For example, hydrocarbons such as pentane, hexane, heptane, and cyclohexane Halogenated hydrocarbons such as methylene chloride and chloroform; aromatic hydrocarbons such as benzene and toluene; lower alcohols such as methanol, ethanol, isopropanol and t-butyl alcohol; esters such as methyl acetate and ethyl acetate; Can be mentioned. These organic solvents may be used alone or in combination of two or more. Of these, hydrocarbons such as pentane, hexane, heptane, and cyclohexane, and lower alcohols such as methanol, ethanol, isopropanol, and t-butyl alcohol are preferable from the viewpoints of solubility and safety.

  The amount of the organic solvent used in the production of the complex of the present invention is not particularly limited as long as all components to be complexed are uniformly dissolved or dispersed, but depending on the solubility of the component to be complexed The amount used can be changed as appropriate. In general, it is preferable to use 1 to 100 times by weight, preferably 3 to 50 times by weight, based on all components to be combined.

  Component (A) γ-oryzanol used in the present invention is a substance that naturally exists in cereals such as rice and corn, and is a mixture of a plurality of types of triterpene alcohol or a compound in which sterol and ferulic acid are ester-bonded. Industrially, it can be obtained by extracting from rice bran or rice germ, and is commercially available from, for example, Tsukino Food Industry Co., Ltd. or Oriza Oil Chemical Co., Ltd. In this invention, such a commercial item can be used, and what is obtained from another origin may be used, and there is no restriction | limiting in particular in the manufacturing method, the refinement | purification method, etc.

  As the component (B) phospholipid used in the present invention, diacylglycerophospholipid having a polar group such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidic acid; soybean, rapeseed, sunflower, safflower, peanut, cotton Examples thereof include natural lecithin obtained from plants such as corn, rice and barley and egg yolk, and hydrogenated products thereof. Furthermore, these may be derivatives modified with a polyoxyalkylene group such as polyethylene glycol. These phospholipids may be used alone or in combination of two or more. Among these, natural lecithin and hydrogenated products thereof are preferable from the viewpoint of obtaining availability and the effects of the present invention. Furthermore, as natural lecithin, those having different contents of phosphatidylcholine (hereinafter, PC) depending on the degree of purification are commercially available, but it is preferable to use those having a PC content of 50 to 90% by weight in the present invention, More preferably, it is 60 to 90% by weight.

The complex of the present invention comprises the aforementioned component (A) γ-oryzanol and component (B) phospholipid, the content of component (A) is 20 to 40% by weight, and the content of component (B) is 60 to 80% by weight. More preferably, the content of the component (A) is 30 to 40% by weight, and the content of the component (B) is 60 to 70% by weight. By using the complex thus obtained, γ-oryzanol can be easily emulsified or solubilized at a high concentration. In the present invention, high concentration means that γ-oryzanol is mixed in an emulsified or solubilized composition in an amount of 0.05% by weight or more, more preferably 0.1% by weight or more.
In addition, the emulsified or solubilized composition obtained using the composite of the present invention has a transparent appearance and good dispersion stability. In the present invention, “transparency” means that the appearance of the liquid is transparent when the sample is placed in a glass bottle having a diameter of 3.5 cm and observed from the side. When measuring turbidity with a spectrophotometer, the transmittance is 20% or more when a sample is put in a cell having a thickness of 1 cm and measured at a wavelength of 600 nm.
When the content of the component (A) in the composite is less than 20% by weight, when γ-oryzanol is blended at a high concentration, the appearance of the resulting emulsified or solubilized composition is not transparent, and the dispersion is stable. Also worse. Conversely, if the content of component (A) is more than 40% by weight, γ-oryzanol cannot be dispersed in water.

  Cosmetics containing the composite of the present invention include water and additives added to normal cosmetics as necessary, such as oil bases, surfactants, alcohols, humectants, polymers, thickeners, Gelling agent, antioxidant, antiseptic, bactericidal agent, chelating agent, pH adjuster / acid / alkali, UV absorber, whitening agent, solvent, exfoliating / dissolving agent, antipruritic agent, anti-inflammatory agent, antiperspirant, Refreshing agents, antihistamines, astringents, stimulants, hair growth agents / blood circulation promoters, reducing agents / oxidants, polymer powders, hydroxy acids, vitamins and derivatives thereof, saccharides and derivatives thereof, organic acids, enzymes , Nucleic acids, hormones, inorganic powders, fragrances, pigments and the like may be contained to the extent that the effects of the present invention are not impaired.

  Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as cannic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Hydrocarbons such as paraffin; candelilla wax, carnauba wax, rice wax, wax wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Tropsch wax, polyethylene wax, waxes such as ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cacao butter, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Fats and oils; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof, phospholipids such as lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospho Phospholipid derivatives such as lipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanostero , Sterols such as dihydrolanosterol, phytosterol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamate di (cholesteryl / behenyl) / Octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl) ), Acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid choles Steryl esters such as teryl, macadamia nut oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipids / cholesterol Complexes, lipid complexes such as phospholipid / phytosterol complexes; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl parimilate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isononanoic acid Isotridecyl, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, ne Isotridecyl pentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid cure Castor oil, ethyl oleate, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, methyl heptyl laurate, methyl heptyl palmitate, methyl heptyl palmitate, methyl isostearate Heptyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, Monoalcohol carboxylic acid esters such as diisopropyl pinate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate; cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, γ-ercalactone Oxyesters such as: glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic acid / capric acid), tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl , Hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, triisostearate Trimethylol propane acid, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin Pentaerythrityl, triethylhexanoic acid ditrimethylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, triethylhexanoic acid pentaerythrityl, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diisostearate diglyceryl, tetraisostearic acid Polyglyceryl, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, ( Hexyl decanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate, etc. Polyhydric alcohol fatty acid esters; alkyl ethers such as dicaprylyl ether; diisopropyl dimerolinolate diisostearyl, dimerdilinoleate diisostearyl, dimerdilinoleate di (isostearyl / phytosteryl), dimerdilinoleic acid (phytosteryl / behenyl) ), Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearic dimer dilinoleyl, die -Dimerinoyl hydrogenated rosin condensate, dimer linoleic acid hydrogenated castor oil, dimer acid or dimer diol derivative such as hydroxyalkyl dimer linoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide) DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA) , Fatty acid alkanolamides such as coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), high polymerization Methicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, Silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, polyether-modified silicone such as cation-modified silicone and dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone , Sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino Non-acid modified silicone, peptide modified silicone, fluorine modified silicone, cation modified and polyether modified silicone, amino modified and polyether modified silicone, alkyl modified and polyether modified silicone, amide alkyl modified silicone, amino glycol modified silicone, aminophenyl modified Preferable examples include silicones such as silicone and polysiloxane / oxyalkylene copolymer; and fluorine-based oils such as perfluorodecane, perfluorooctane and perfluoropolyether.

  As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosane diacid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan Sulfuric acid; white jellyfish extract; white jellyfish polysaccharide; fructans such as inulin and levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; organic acids such as citric acid, tartaric acid and lactic acid and salts thereof; urea; 2-pyrrolidone-5 -Carboxylic acid and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine Amino acids and salts thereof such as glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagenolytic peptide, Hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic Peptides, wheat proteolytic peptides, hydrolyzed wheat proteins, casein degrading peptides, acylated peptides and other protein peptides and their Derivatives; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, Glutathione, albumin, whey; choline chloride, phosphorylcholine; placental extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayobara extract, yarrow extract Animal / plant extract components such as eucalyptus extract and merirot extract, natural ceramide (type 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide and sugar ceramide-containing extract Ceramides can be mentioned as preferred.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acylamino acid salts such as sodium phosphate, triethanolamine cocoylglutamate, sodium lauroylglutamate, sodium myristoylglutamate, sodium stearoylglutamate, ditriethanolamine palmitoylaspartate, cocoylalaninetriethanolamine, lysine Nadilauroylglutamate; sodium laureth acetate, etc. Polyoxyethylene alkyl ether acetates; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; Fatty acid glyceride sulfate such as coconut oil fatty acid sodium glycerin sulfate; Oxyethylene sulfate; Olefin sulfonate such as sodium α-olefin sulfonate; Alkyl sulfosuccinate such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; Disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate Alkyl ether sulfosuccinates such as sodium acid, sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonate; alkanesulfonate; α-sulfo fatty acid methyl ester salt; acyl isethionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetates; alkyl ether phosphates such as sodium laureth phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate esters such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphorus Acid salts; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof; silicone-based shades such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone Nonionic surfactants such as ionic surfactants, laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steale Various polyoxyethylene addition numbers such as bis (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether), octyldecesses (polyoxyethylene octyldodecyl ether) Polyoxyethylene alkyl ethers; polyoxyethylene alkyl phenyl ethers; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, Castor oil and hardened castor oil derivatives such as polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hardened castor oil maleic acid; Polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether; Polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol ; (Poly) glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; Glyceryl isostearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl palm oil fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-pyroglutamate oleate, monostearate Glycerin fatty acid partial esters such as glyceryl malic acid; polyglyceryl stearate-2, 3, 4, 5, 6, 8, 8, disglyceryl-6, 10, polyglyceryl tristearate 2, polyglyceryl-10 decastearate, polyglyceryl-2 isostearate, 3, 4, 5, 6, 6, 8, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 1 Polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, dioleate polyglyceryl- 6, polyglyceryl fatty acid ester such as polyglyceryl-2 trioleate, polyglyceryl-10 decaoleate; ethylene glycol mono fatty acid ester such as ethylene glycol monostearate; propylene glycol mono fatty acid ester such as propylene glycol monostearate; pentaerythritol moiety Fatty acid ester; sorbitol partial fatty acid ester; maltitol partial fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate Sorbitan fatty acid esters such as sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; Sugar derivatives partial esters such as sucrose fatty acid ester, methyl glucoside fatty acid ester and undecylenic acid trehalose; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; glycolipid such as mannosyl erythritol lipid; lanolin alcohol; reduced lanolin; Stearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate, etc. Polyoxyethylene fatty acid mono- and diesters; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene sorbitan monooleate; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate, and other polyoxyethylene sorbitan fatty acid esters; poly Oxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene Polyoxyethylene sorbitol fatty acid esters such as bitol pentaoleate and polyoxyethylene sorbitol monostearate; Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax Alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; Natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil fatty acid monoethano Luamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide Fatty acid alkanolamides such as (partamide MEA), palmitic acid diethanolamide (partamide DEA), and palm oil fatty acid methylethanolamide (cocamidomethyl MEA); alkyl such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide Polydimethyl ether oxide; alkyl ethoxy dimethyl amine oxide; polyoxyethylene alkyl mercaptan; polyether such as dimethicone copolyol Silicone-based nonionic surfactants such as silicone-modified silicones, polysiloxane / oxyalkylene copolymers, polyglycerin-modified silicones, sugar-modified silicones, etc .; for cationic surfactants, behentrimonium chloride, steartrimonium chloride Alkyltrimethylammonium chloride such as cetrimonium chloride and lauryltrimonium chloride; alkyltrimethylammonium bromide such as stearyltrimonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; stearamidepropyldimethylamine; Fatty acid amidoamines such as stearamide ethyl diethylamine and salts thereof; alkyl ether amines such as stearoxypropyldimethylamine; and Salt or quaternary salt of fatty acid amide type quaternary ammonium salt such as ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamine and its Alkylamine salt; fatty acid amidoguanidinium salt; alkyl etheraminemonium salt; alkyltrialkylene glycol ammonium salt; benzalkonium salt; benzethonium salt; pyridinium salt such as cetylpyridinium chloride; imidazolinium salt Alkyl isoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyl dimethicone and amodimethicone; cation-modified silicones; And silicone-based cationic surfactants such as polyether-modified silicones, amino-modified and polyether-modified silicones, etc .; in amphoteric surfactants, N-alkyl-N, N- such as laurylbetaine (lauryldimethylaminoacetic acid betaine) Dimethylamino acid betaine; fatty acid amide alkyl-N, N-dimethylamino acid betaine such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline type betaine such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyl sulfobetaine such as alkyldimethyltaurine; alkyl Sulfate-type betaines such as dimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; phosphatidylcholine, phosphatidylethanolamine , Sphingophospholipids such as phosphatidylserine and sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, hydroxylated lecithin, etc .; silicone Preferred examples of the polymeric surfactant include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymer, and various silicone surfactants.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazoline derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzoyl chloride Luconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol , Photosensitizers, antibacterial zeolite, and silver ion are preferable, but when used as an antibacterial agent or antiseptic agent for antiseptic purposes, phenoxyethanol; 1 from the viewpoint of safety of cosmetics or skin external preparations; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.

  Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

  Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid-based UV absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone purple 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphsulfone Preference is given to acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

  Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

  As plant / animal / microbe extracts, Iris extract, Ashitaba extract, Asunaro extract, Asparagus extract, Avocado extract, Achacha extract, Almond extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Ginkgo biloba extract, Ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.

  As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Base dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4- Nitro dyes such as hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2 and Basic Blue 26; disperse dyes; inorganic white such as titanium dioxide and zinc oxide Pigments: Inorganic red pigments such as iron oxide (Bengara) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and loess; Black iron oxide, low-order titanium oxide, etc. Inorganic pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica; Titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil; aluminum powder, copper powder, gold, etc. Surface treated inorganic and metal powder pigments: Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204 No., Yellow 205, Yellow 401, Blue 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Organic pigments such as zirconium, barium or aluminum lake such as yellow 5, yellow 202, yellow 203, green 3 and blue 1; surface treatment organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene , Catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochini Natural pigments and dyes such as naphthoquinones such as ru and shikonin, bixin, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m- Oxidative dye intermediates and couplers such as p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; Oxidizing dyes; dihydroxyacetone is preferred.

  Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  Examples of the cosmetic or skin external preparation of the present invention include skin external preparations such as hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and ointments. From the viewpoint of exerting the effects of the present invention, it can be preferably used particularly for hair cosmetics and basic cosmetics. The cosmetic of the present invention can be produced according to a usual method.

  The cosmetic or skin external preparation of the present invention will be described in further detail. Examples of hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, and rinse-integrated shampoos. Rinsing, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow, split hair coat , Hair oil, permanent wave agent, straight permanent agent, oxidative hair dye, hair bleach, hair color pretreatment, hair color after treatment, permanent pretreatment, permare Terpolymers treatments, hair manicure, and as hair growth agents are preferred.

  Basic cosmetics include soft lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, Nourishing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; Liposome cosmetics such as liposomal serum and liposome lotion; packs and masks such as peel-off pack, powder pack, washing pack, oil pack, cleansing mask; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing gel Facial cleansers such as oils, cleansing masks, powders and facial cleansers; cosmetic soaps, transparent soaps, medicated soaps, liquid soaps, shaving soaps, synthetic cosmetic soaps Soap can be mentioned as preferred.

  As makeup cosmetics, white powder, dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment are preferable. .

  Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.

  Body cosmetics include body shampoos and other body cleansers, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics, depigmenting agents, depilation / hair removal agents, bathing agents, insect repellents, etc. A repeller is preferred.

  Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

  As the dosage form of the cosmetic or external preparation for skin of the present invention, emulsification such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type, etc. Type cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, pastes Preferred examples include cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

  The following examples further illustrate the present invention in detail but are not to be construed to limit the scope thereof.

Manufacture of composites After a total of 10 g of γ-oryzanol and hydrogenated soybean lecithin was dissolved in 80 g of t-butyl alcohol with the composition shown in Table 1, it was immediately frozen in liquid nitrogen and freeze-dried (Tokyo Rika Kikai Co., Ltd., The product was freeze-dried with FDU-2200 type. The pressure was 10 Pa or less and the trap temperature was −80 ° C. The composites thus obtained were all homogeneous white powders. Examples 1-3 are composites within the range of the composition of the present invention, Comparative Examples 1-2 are composites outside the range of the composition of the present invention, and Comparative Examples 3-4 are ranges of the composition of the present invention. However, the PC purity of hydrogenated soybean lecithin is different from the examples.

Preparation and Evaluation of Aqueous Dispersion Using the composites of Examples 1 to 3, the aqueous dispersion was prepared with the composition shown in Table 2 so that the amount of γ-oryzanol was 0.05% by weight based on the aqueous dispersion. Prepared (Examples 4-6). Similarly, aqueous dispersions having the compositions shown in Table 2 were prepared using the composites of Comparative Examples 1 to 4 (Comparative Examples 5 to 8). The obtained aqueous dispersion was evaluated for initial dispersibility, transparency / transmittance, and dispersion stability by the following methods, and the results are also shown in the lower column of Table 2.
Next, an aqueous dispersion was prepared with the composition shown in Table 3 using the composites of Examples 1 to 3 so that the blending amount of γ-oryzanol was 0.1% by weight with respect to the aqueous dispersion (implementation). Examples 7-9). Similarly, aqueous dispersions having the compositions shown in Table 3 were prepared using the composites of Comparative Examples 1 to 4 (Comparative Examples 9 to 12). The obtained aqueous dispersion was evaluated for initial dispersibility, transparency / transmittance, and dispersion stability by the following methods, and the results are also shown in the lower column of Table 3.

<Initial dispersibility>
About the obtained aqueous dispersion, the dispersion state immediately after preparation was observed visually, and initial dispersibility was evaluated according to the following evaluation criteria.

○ ・ ・ ・ Uniformly dispersed × ・ ・ ・ Not uniformly dispersed

<Transparency / Transparency>
The obtained aqueous dispersion was put in a glass bottle having a diameter of 3.5 cm, the appearance was visually observed from the side, and the transparency was evaluated according to the following evaluation criteria. Further, the transmittance of the aqueous dispersion was measured using a spectrophotometer (cell thickness: 1 cm, wavelength: 600 nm).

○ ... The back of the liquid can be seen through. × ... The back of the liquid cannot be seen through.

<Dispersion stability>
The obtained aqueous dispersion was subjected to a storage stability test at 50 ° C./month, and the dispersion stability was evaluated according to the following evaluation criteria.

○ ・ ・ ・ Uniformly dispersed after storage × ・ ・ ・ Not uniformly dispersed after storage or precipitation occurs

（調製方法）
Ｎｏ．１〜２を７０℃で攪拌し、均一に分散後、この液を予め約７０℃でＮｏ．３とＮｏ．４を加温溶解させた水相に添加し、ホモミキサーにて攪拌（７０℃、５０００ｒｐｍ、２０分）した。

(Preparation method)
No. Nos. 1 and 2 were stirred at 70 ° C. and uniformly dispersed. 3 and no. 4 was added to the aqueous phase dissolved by heating, and stirred with a homomixer (70 ° C., 5000 rpm, 20 minutes).

（調製方法）
Ｎｏ．１〜２を７０℃で攪拌し、均一に分散後、この液を予め約７０℃でＮｏ．３とＮｏ．４を加温溶解させた水相に添加し、ホモミキサーにて攪拌（７０℃、５０００ｒｐｍ、２０分）した。

(Preparation method)
No. Nos. 1 and 2 were stirred at 70 ° C. and uniformly dispersed. 3 and no. 4 was added to the aqueous phase dissolved by heating, and stirred with a homomixer (70 ° C., 5000 rpm, 20 minutes).

  From the results in Tables 2 and 3, the aqueous dispersion containing γ-oryzanol at a high concentration prepared using the composite of the present invention was excellent in initial dispersibility, transparency, and dispersion stability. On the other hand, the composite of Comparative Example 1 having a small content of γ-oryzanol in the composite had good initial dispersibility but no transparency and insufficient dispersion stability. The composite of Comparative Example 2 having a high γ-oryzanol content in the composite had insufficient dispersibility from the beginning. In addition, the aqueous dispersion using the composites of Comparative Examples 3 and 4 also has insufficient dispersibility from the beginning, and even if the γ-oryzanol content is within the scope of the present invention, the PC content of lecithin is different. It was suggested that the dispersibility becomes insufficient.

Example 10 Whitening lotion This lotion is excellent in transparency and whitening effect, keeps the skin healthy, and can prevent wrinkles due to rough skin and dryness.

Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 1 0.5
Glycerin 8.0
Part B 3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 1.0
Purified water 20.0
BG 5.0
Ethanol 3.0
DPG 2.0
Methyl Gluces-10 2.0
Glycyrrhizic acid 2K 0.05
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.01
Xanthan gum 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid 0.1
Amount of sodium citrate in which the pH is 4.5 Part C Purified water Amount in total of 100 ----------------------- ----------
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A and part C were each heated to 70 ° C., and part A was added while stirring part C with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part B mixed in advance was added to obtain a uniform liquid.

Example 11 Whitening lotion This lotion is transparent, has an excellent whitening effect, keeps the skin healthy, and prevents wrinkles caused by rough skin and dryness.

Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.3
Glycerin 6.0
Part B purified water 30.0
DPG 3.0
Part C Tranexamic acid (Nippon Seika) 2.0
Purified water 20.0
Niacinamide 0.3
Betaine 1.0
Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolu-Aquorio: Nippon Seika) 0.5
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 12 Moisturizing lotion This lotion was a highly transparent preparation. It also moisturizes the skin, keeps it fresh by suppressing moisture transpiration, and prevents wrinkles caused by dry skin and dryness.

Component Blending amount (% by weight)
--------------------------------------
Part A Composite of Example 2 0.3
Diglycerin 3.0
Glycerin 8.0
Part B purified water 40.0
Arginine 0.05
Part C Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (Neosolu-Aculio: Nippon Seika) 1.0
Betaine 0.5
Glyceres-26 0.2
Hydrolyzed hyaluronic acid 0.01
Pullulan 0.5
Hyaluronic acid Na 0.01
Hydroxyethyl cellulose 0.03
Carboxyvinyl polymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 13 Moisturizing lotion This lotion is highly transparent, has an excellent moisturizing effect, moisturizes the skin, keeps it fresh, and prevents wrinkles due to dry skin and dryness.

Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.25
Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6
(Phytopresome-Cera236: Nippon Seika) 0.1
Glycolipid, hydrogenated lecithin, BG, glycerin (Phytopresome-MEL: Nippon Seika) 0.8
BG 5.0
Glycerin 12.0
Inositol 1.0
Part B purified water 20.0
Part C (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10
(Neosol-AquaS: Nippon Seika) 1.0
PEG / PPG / polybutylene glycol-8 / 5/3 glycerol 0.5
Glucosylceramide 0.5
Glucosyl trehalose 0.5
Polyquaternium-51 0.5
Acetyl hexapeptide-8 0.001
Hydrolyzed collagen 0.05
EDTA-2Na 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 14 Osmotic Toner Lotion This skin lotion has a sense of penetration into the skin, keeps it moist and fresh, and prevents wrinkles due to skin dryness and dryness.

Component Blending amount (% by weight)
-----------------------------------
Part A Composite of Example 3 0.7
Oleyl oleate 0.03
Glycerin 10.0
Part B Glucose 1.0
DPG 3.0
Cocoyl Arginine Ethyl PCA 0.05
Polylysine 0.05
Tripropylene glycol 1.0
Purified water 20.0
Part C Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexyl glycerin 0.2
Acetylglucosamine 0.03
Poly HEMA glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Chitosan 0.05
Hydroxyethyl cellulose 0.05
Hyaluronic acid Na 0.01
Carbomer 0.06
Hydroxide K 0.03
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dispersed uniformly. Part C was mixed, stirred well, homogenized, and heated to about 70 ° C. Part B was stirred with a propeller to prepare a nano vesicle solution. C part was added to A part, it stirred using the homomixer at about 70 degreeC, it cooled to about 40 degreeC, and the liquid mixture of B part was added.

Example 15 Gel lotion This skin lotion has a feeling of penetrating into the skin, keeps it moist and fresh, and prevents wrinkles due to skin dryness and dryness.

Component Blending amount (% by weight)
-----------------------------------
Part A Composite of Example 3 0.25
Glycerin 10.0
Sorbitol solution (70%) 5.0
PEG-10 Dimethicone 0.4
Part B Glucose 1.0
DPG 3.0
Tripropylene glycol 1.0
Purified water 20.0
Part C Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexyl glycerin 0.2
Poly HEMA glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Carrageenan 0.05
Hyaluronic acid Na 0.01
Carbomer 0.06
Hydroxide K 0.05
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dispersed uniformly. Part C was mixed, stirred well, homogenized, and heated to about 70 ° C. Part B was stirred with a propeller to prepare a nano vesicle solution. C part was added to A part, it stirred using the homomixer at about 70 degreeC, it cooled to about 40 degreeC, and the liquid mixture of B part was added.

Example 16 Moisturizing lotion This lotion is highly transparent, excellent in moisturizing effect, moisturizes the skin, keeps it fresh, and prevents wrinkles due to skin dryness and dryness.

Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 1 0.9
Glycerin 6.0
PEG-50 hydrogenated castor oil 0.3
Polyglyceryl laurate-10 0.2
Macadamia nut oil fatty acid phytosteryl (Plandool-MAS: Nippon Seika) 0.05
Part B purified water 20.0
Part C Polyquaternium-51 0.5
Acetyl hexapeptide-8 0.001
Hydrolyzed collagen 0.05
EDTA-2Na 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 17 Moisturizing lotion This lotion is highly transparent, has an excellent moisturizing effect, moisturizes the skin, keeps it fresh, and prevents wrinkles due to skin dryness and dryness.

Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.2
Glycerin 8.0
Lysolecithin 0.03
Cyclic lysophosphatidic acid Na 0.001
Part B purified water 20.0
Part C Hydrolyzed collagen 0.05
Citric acid 0.01
Na citrate 0.09
EDTA-2Na 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 18 Transparent Gel This gel had a sense of penetration into the skin. It also keeps the skin moist and fresh and prevents fine wrinkles due to skin dryness and dryness.

Component Blending amount (% by weight)
--------------------------------------
Part A Composite of Example 2 0.4
Glycerin 5.0
PPG-6 decyltetradeces-30 0.2
PEG-30 phytosterol 0.3
Phytopresome-MEL (Nippon Seika) 0.8
Purified water 30.0
Part B PEG-4000 0.2
Methyl Gluces-10 1.0
Pyridoxine hydrochloride 0.05
Ethylhexyl glycerin 0.2
Phenoxyethanol 0.4
Cyclic lysophosphatidic acid Na 0.001
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.01
Hydrolyzed collagen 0.01
Purified water Amount of part C totaling 100 parts Pentate acid 5Na 0.05
(Ammonium dimethyltaurate acrylate / vinylpyrrolidone) Copolymer 0.05
(Acrylates / alkyl acrylate (C10-30)) cross polymer 0.15
Arginine 0.25
Purified water 30.0
---------------------------------------
(Preparation method)
Part A was stirred with a propeller to prepare a nano vesicle solution. Part C was a viscous liquid when mixed. Part B was mixed to obtain a uniform liquid. Part A and part B were added to part C to make it uniform.

Example 19 Moisturizing lotion This lotion is a highly transparent preparation, moisturizes the skin, keeps it fresh by inhibiting moisture transpiration, and prevents wrinkles due to skin dryness and dryness.

Component Blending amount (% by weight)
--------------------------------------
Part A Composite of Example 3 0.3
Diglycerin 3.0
Glycerin 8.0
Part B purified water 20.0
Arginine 0.05
Part C (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10
(Neosol-AquaS: Nippon Seika) 1.0
Betaine 0.5
Polylysine 0.01
Hydrolyzed hyaluronic acid 0.01
Pullulan 0.5
Hyaluronic acid Na 0.01
Hydroxyethyl cellulose 0.03
Chitosan 0.02
Carboxyvinyl polymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 20 Moisturizing lotion This lotion was a highly transparent preparation. It also moisturizes the skin, keeps it fresh by suppressing moisture transpiration, and prevents wrinkles caused by dry skin and dryness.

Component Blending amount (% by weight)
--------------------------------------
Part A Composite of Example 2 0.8
Diglycerin 1.0
Glycerin 8.0
Lauroyl glutamate di (phytosteryl / octyldodecyl)
(Plandool-LG2: Nippon Seika) 0.1
Phytosteryl isostearate (Plandool-ISS: Nippon Seika) 0.05
Polysorbate 20 0.3
Part B purified water 30.0
Part C Maltitol solution 1.0
Betaine 0.5
α-glucan oligosaccharide 0.1
Pullulan 0.5
Tuberose polysaccharide 0.01
Hydroxypropyl methylcellulose stearoxy ether 0.05
(Acrylates / alkyl acrylate (C10-30)) Crosspolymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, the mixture was dispersed with a high-pressure emulsifier (Microfluidizer manufactured by Mizuho Industries). After cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 21 Moisturizing lotion This lotion was a highly transparent preparation. It also moisturizes the skin, keeps it fresh by suppressing moisture transpiration, and prevents wrinkles caused by dry skin and dryness.

Component Blending amount (% by weight)
--------------------------------------
Part A Composite of Example 3 0.2
Diglycerin 1.0
Glycerin 8.0
Dimer dilinoleic acid di (isostearyl / phytosteryl)
(LUSPLAN PI-DA: Nippon Seika) 0.05
Bisdiglyceryl polyacyl adipate-2
(Plandool-DP: Nippon Seika) 0.05
Part B purified water 30.0
Part C Mannitol 1.0
PEG-30 1.0
Hydrolyzed collagen 0.1
Pullulan 0.5
Tremoist-TP (Nippon Seika) 0.01
Hydroxyethyl cellulose 0.03
Carboxyvinyl polymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, the mixture was dispersed with a high-pressure emulsifier (Microfluidizer manufactured by Mizuho Industries). After cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 22 Scalp Lotion This lotion is a highly transparent preparation, which can soften the scalp and improve the stickiness and roughness of the scalp.

Component Blending amount (% by weight)
------------------------------------
Part A Composite of Example 3 0.3
Glycerin 4.0
Pentylene glycol 2.0
Maltitol 0.5
Part B purified water 50.0
Part C ethanol 10.0
Neosolu-Aquilio (Nippon Seika) 1.0
Tocopherol acetate 0.05
Menthol 0.1
Menthoxypropanediol 0.05
Betaine 0.2
Hydroxypropyl chitosan solution 0.05
Carrot extract 0.1
Assembly extract 0.1
Japanese cypress rafji root extract 0.003
Pyridoxine hydrochloride 0.05
Panthenol 0.1
PCA-Na 0.1
Penteto acid 5Na 0.05
Methylparaben 0.1
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 23 Skull Lotion This lotion is a highly transparent preparation, which can soften the scalp and improve the stickiness and roughness of the scalp.

Component Blending amount (% by weight)
------------------------------------
Part A Complex of Example 1 0.3
Pentylene glycol 2.0
PEG-60 hydrogenated castor oil 0.3
Part B purified water 50.0
Part C Neosolue-Aculio (Nippon Seika) 1.0
Tremoist-TP (Nippon Seika) 0.01
Pyridoxine hydrochloride 0.05
Malic acid 0.01
Oyster tannin 0.005
Anhydrous caffeine 0.001
Hydrolyzed collagen 0.05
Penteto acid 5Na 0.05
Methylparaben 0.1
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 24 Scalp Lotion This lotion has high transparency, excellent moisturizing and penetrating feeling, improves the condition of the scalp, and can suppress stickiness and rustiness.

Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 6.0
Complex of Example 3 0.3
Part B Neosolute-AquaS (Japan Seika) 0.5
Raffinose 0.2
Arginine 0.5
Glycine 0.1
Purified water 50.0
Part C Ethanol 5.0
Methylparaben 0.1
Menthoxypropanediol 0.1
Ethyl dicarboethoxy pantothenate 0.2
Camphor 0.1
Carrot extract 1.0
Glycosyl trehalose 0.5
Nicotinamide 1.0
Dipotassium glycyrrhizinate 0.1
VC ethyl (Nippon Seika) 0.3
Hyaluronic acid Na 0.01
Tremoist-SL (Nippon Seika) 0.5
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 25 Hair Growth Agent This hair growth agent was a preparation that was highly transparent, excellent in moisturizing feeling and penetrating feeling, improved the state of the scalp, and suppressed stickiness and roughness.

Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 2.0
Complex of Example 2 0.5
PEG-60 hydrogenated castor oil 0.3
Part B Betaine 0.5
Purified water 50.0
Part C ethanol 20.0
Menthoxypropanediol 0.1
Orange oil 0.05
Panthenyl ethyl ether 0.2
Glutamic acid 0.1
Polydimethyldimethylmethylenepiperidinium solution 0.1
Carrot extract 5.0
Assembly extract 1.0
Trehalose 0.5
Nicotinamide 1.0
Piroctone olamine 0.1
Dipotassium glycyrrhizinate 0.1
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 26 Hair Growth Agent This hair growth agent was a formulation with high transparency, excellent moisturizing feeling and penetrating feeling, improved scalp condition, and expected hair growth effect.

Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 4.0
BG 3.0
Complex of Example 3 0.1
Phytopresome-MEL (Nippon Seika) 1.0
Part B Neosolu-Aquorio (Nippon Seika) 0.5
DPG 2.0
Lactic acid 0.1
Tremoist-TP (Nippon Seika) 0.01
Purified water 50.0
Part C ethanol 10.0
Menthol 0.1
Menthyl glyceryl ether 0.15
Panthenyl ethyl ether 0.2
Camphor 0.1
Cordyceps extract 1.0
Assembly extract 1.0
Hydrolyzed hyaluronic acid 0.02
Cyclic lysophosphatidic acid Na 0.001
Pepper extract 0.01
Betaine 0.3
Trehalose 0.2
Cymene-5-ol 0.1
Tocopherol acetate 0.05
β-glycyrrhetinic acid 0.05
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Claims (3)

The following components (A) and (B);
(A) An emulsified or solubilized composition obtained by removing an organic solvent from a solution in which γ-oryzanol (B) phospholipid is uniformly dissolved in the organic solvent and simultaneously depositing the components (A) and (B) In the γ-oryzanol-phospholipid complex for cosmetics or skin external preparations used for the preparation of products, the content of (A) is 20 to 40% by weight, and the content of (B) is 60 to 80% by weight A complex characterized in that The complex according to claim 1, wherein the phospholipid of component (B) is lecithin having a phosphatidylcholine (PC) content of 50 to 90% by weight. A cosmetic or external preparation for skin comprising the complex according to claim 1 or 2.