JP2018048097A - Cosmetic or skin external preparation containing tranexamic acid - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic or a skin external preparation which suppresses crystal precipitation in a cosmetic or a skin external preparation containing tranexamic acid, a derivative thereof or a sat thereof.SOLUTION: There is provided a cosmetic or a skin external preparation comprising the following components (A) and (B) as essential components, which sufficiently suppresses crystal precipitation of tranexamic acid and can reduce a risk of crystal precipitation of tranexamic acid even if tranexamic acid is blended at a high concentration: (A) tranexamic acid, a derivative thereof or a sat thereof and (B) phytic acid or a salt thereof.SELECTED DRAWING: None

Description

  The present invention relates to (A) tranexamic acid or a derivative thereof or a salt thereof, and (B) a cosmetic or skin external preparation containing phytic acid or a salt thereof. Further, as (C), the present invention relates to a cosmetic or skin external preparation containing one or more selected from carboxyvinyl polymer, alkyl methacrylate copolymer, hyaluronic acid, carboxymethylcellulose and white jellyfish polysaccharide. .

Tranexamic acid has a hemostatic action and an anti-inflammatory action, so that it is used as an active ingredient of pharmaceuticals, and has a rough skin improving action and a whitening action, and is therefore widely used in cosmetics and skin external preparations.
However, while tranexamic acid is water-soluble, it has very high crystallinity, and there is a problem that crystals are easily precipitated by evaporation of moisture. For example, there is a problem that crystals precipitate over time during the storage of the preparation, or hard crystals precipitate in the preparation attached to the mouth of the container or the like as the water evaporates. Such crystal precipitation is not preferable because it changes the appearance of the product and gives a rough feeling of use.

  As a solution to the above problem, for example, a composition containing tranexamic acid, a higher alcohol, and a long-chain acyl sulfonate anionic surfactant having a pH of 3.0 to 6.0 (Patent Document 1), tranexam A composition containing acid, oil, PEG-60 hydrogenated castor oil and adjusted to pH 5.5 or lower with an organic / inorganic acid (Patent Document 2), a composition containing tranexamic acid and polyhydroxy acid (Patent Document) 3) A composition containing tranexamic acid, inositol, polyhydric alcohol (Patent Document 4) and the like have been disclosed, but not necessarily sufficient.

Patent 2011-084551 JP2011-195460 JP2013-121955A JP2006-121092

  The problem to be solved by the present invention is to provide a cosmetic or an external preparation for skin, in which crystal precipitation is suppressed in a cosmetic or an external preparation for skin containing tranexamic acid or a derivative thereof or a salt thereof.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have used the component (A) tranexamic acid or a derivative thereof or a salt thereof and the component (B) phytic acid or a salt thereof in combination, The inventors have found that crystal precipitation is suppressed, and have completed the present invention. Further, as component (C), by containing one or more selected from carboxyvinyl polymer, alkyl acrylate methacrylate copolymer, hyaluronic acid, carboxymethyl cellulose and white jellyfish polysaccharide, tranexamic acid It was found that crystal precipitation is further suppressed.

  The cosmetic or external preparation for skin of the present invention is one in which crystal precipitation of tranexamic acid is sufficiently suppressed, and even if tranexamic acid is blended in a high concentration, the concern about crystal precipitation of tranexamic acid can be reduced.

The cosmetic or external preparation for skin of the present invention contains the following components (A) and (B) as essential components.
(A) tranexamic acid or a derivative thereof or a salt thereof (B) phytic acid or a salt thereof Further, in the cosmetic or skin external preparation of the present invention, as (C), carboxyvinyl polymer, alkyl methacrylate methacrylate copolymer 1 type, or 2 or more types selected from a coalescence, hyaluronic acid, carboxymethylcellulose, and a white jellyfish polysaccharide can be contained.

  The component (A) tranexamic acid or a derivative thereof or a salt thereof used in the cosmetic or external preparation for skin of the present invention will be described. Tranexamic acid is also called trans-4-aminomethylcyclohexane-1-carboxylic acid, It is a compound having both an amino group and a carboxyl group. The tranexamic acid used for this invention may be mix | blended with the form as it is, or may be mix | blended with the form of a salt. The salt of tranexamic acid is not particularly limited. Specifically, alkali metal salts such as sodium and potassium; alkaline earth metal salts such as calcium and magnesium; metal salts such as aluminum, iron and zinc; lysine, Examples include basic amino acid salts such as arginine, histidine and ornithine; organic amine salts such as ammonium, monoethanolamine, diethanolamine, triethanolamine and stearylamine. In addition, component (A) may be a tranexamic acid derivative or a salt thereof, and specific examples include ester derivatives such as tranexamic acid cetyl ester; amide derivatives such as tranexamic acid methylamide. Of these, the present invention is particularly effective for suppressing crystal precipitation of tranexamic acid.

  The component (B) phytic acid or a salt thereof used in the cosmetic or external preparation for skin of the present invention will be described. Phytic acid has a structure in which all six hydroxy groups of inositol are phosphorylated. Nine types of compounds are known as isomers, but myo-inositol-1,2,3,4,5,6-hexaphosphate is generally used. In the present invention, any isomer may be used, and some of the six hydroxy groups may not be phosphorylated. Phytic acid is contained in most plants in the form of a combined salt (phytin) with minerals such as calcium and magnesium, and can be industrially extracted from rice bran or corn with water or an acidic aqueous solution. It can be obtained as a commercial product from Tsukino Food Industry Co., Ltd., Shikishima Starch Co., Ltd., FC Chemical Co., Ltd. or the like. The phytic acid used in the present invention may be formulated as it is or in the form of a salt. The salt of phytic acid is not particularly limited. Specifically, alkali metal salts such as sodium and potassium; alkaline earth metal salts such as calcium and magnesium; metal salts such as aluminum, iron and zinc; lysine, Examples include basic amino acid salts such as arginine, histidine and ornithine; organic amine salts such as ammonium, monoethanolamine, diethanolamine, triethanolamine and stearylamine.

  In the cosmetic or skin external preparation of the present invention, the component (B) can sufficiently obtain the excellent effects of the present invention with a smaller blending amount than the component (A). Specifically, the component (B) may be blended 0.001 times or more by weight ratio with respect to the component (A), more preferably 0.005 times or more, and most preferably 0.01 times or more. Although there is no restriction | limiting in particular as an upper limit of the compounding quantity of a component (B), Usually, it is less than 1.0 time, Preferably it is less than 0.5 time, More preferably, it is less than 0.1 time by weight ratio. By blending the component (B) at such a ratio, it is possible to obtain an effect of suppressing crystal precipitation of tranexamic acid. Further, the amount of the component (A) of the present invention to be added to the cosmetic or external skin preparation is not particularly limited as long as it can be achieved to the extent that the intended effect and efficacy of the component (A) can be exhibited. Usually, 0.001 to 15% by weight, preferably about 0.01 to 5% by weight can be blended.

  In the cosmetic or skin external preparation of the present invention, as the component (C), one or two kinds selected from carboxyvinyl polymer, alkyl acrylate methacrylate copolymer, hyaluronic acid, carboxymethylcellulose and white jellyfish polysaccharide The above can be contained. Thereby, compared with the case where only a component (B) is mix | blended, it is possible to suppress precipitation of tranexamic acid. Although there is no restriction | limiting in particular as a compounding quantity of a component (C), 0.001-5 weight% with respect to the cosmetics or skin external preparation of this invention, More preferably, it is 0.005-2 weight%, Most preferably May be added in an amount of 0.01 to 1% by weight.

  The pH of the cosmetic or external preparation for skin of the present invention is not particularly limited, but is usually 3 to 9, preferably 4 to 8.5, more preferably 5 from the viewpoint of suppressing the stability of tranexamic acid and crystal precipitation. It is desirable to set it to ~ 8. The pH can be adjusted according to a conventional method using an acid, an alkali, a pH adjuster, etc. described later.

  In addition to the essential ingredients of the present invention, the cosmetic preparation of the present invention contains, in addition to the essential ingredients of the present invention, water and additives that are usually incorporated into cosmetics, such as oil bases, surfactants, alcohols, and humectants. , Polymer / thickening / gelling agent, antioxidant, preservative, bactericidal agent, chelating agent, pH adjuster / acid / alkali, UV absorber, whitening agent, solvent, exfoliating / dissolving agent, antipruritic agent, Anti-inflammatory agent, antiperspirant, refreshing agent, antihistamine, astringent, stimulant, hair-growth agent / blood circulation promoter, reducing agent / oxidant, polymer powder, hydroxy acid, vitamins and derivatives thereof, saccharides and the like Derivatives, organic acids, enzymes, nucleic acids, hormones, inorganic powders, fragrances, pigments and the like can be blended.

  Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as cannic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Hydrocarbons such as paraffin; candelilla wax, carnauba wax, rice wax, wax wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Tropsch wax, polyethylene wax, waxes such as ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cacao butter, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Fats and oils; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, Phospholipid derivatives such as partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytoster Sterols such as oleol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl) ), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N Acyl sarcosine alkyl esters such as lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phyto Sterols, sunflower seed oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, sterol esters such as long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid -Lipid complexes such as phytosterol complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl paritate, octyldodecyl palmitate, cetyl octoate, hexyldecyl octanoate, isotridecyl isononanoate, isononanoyl isononanoyl , Octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, neopenta Isostearyl acid, octyl dodecyl neodecanoate, oleyl oleate, octyl dodecyl oleate, octyl dodecyl ricinoleate, octyl dodecyl lanolinate, dicaprylyl carbonate, hexyl decyl dimethyloctanoate, octyl dodecyl erucate, isostearic acid hardened castor oil, oleic acid Ethyl, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, methyl heptyl laurate, methyl heptyl myristate, methyl heptyl palmitate, methyl heptyl isostearate, diethyl sebacate , Diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibuty sebacate Monoalcohol carboxylates such as ruoctyl, diisobutyl adipate, dioctyl succinate, triethyl citrate; oxyesters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, γ-ercalactone; Glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic acid / capric acid), tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogen Ester gum added), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, diocta Neopentyl glycol acid, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, triethylhexanoic acid Ditrimethylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate 10. Deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceride Polyhydric alcohol fatty acid esters such as lyloligoester, glycol distearate (ethylene glycol distearate), dineopentanoic acid 3-methyl-1,5-pentanediol, dineopentanoic acid 2,4-diethyl-1,5-pentanediol; Alkyl ethers such as dicaprylyl ether; diisopropyl dilinoleate diisopropyl, dimer dilinoleate diisostearyl, dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate (phytosteryl / behenyl), dimer dilinoleate ( Phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearate dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate, die Dimer acid or dimer diol derivative such as dilinoleic acid hydrogenated castor oil, hydroxyalkyl dimer linoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide ( Lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamid MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl) Fatty acid alkanolamides such as MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane) ), Cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino Amino-modified silicone such as propyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicone such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified Silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone, peptide modified silicone Fluorine modified silicone, cation modified and polyether modified silicone, amino modified and polyether modified silicone, alkyl modified and polyether modified silicone, amide alkyl modified silicone, amino glycol modified silicone, aminophenyl modified silicone, polysiloxane oxy Preferred examples include silicones such as alkylene copolymers; and fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether.

  As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosane diacid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan Sulfuric acid; white jellyfish extract; white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium Salt: betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, aspa Amino acids such as gin, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and the salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagenolytic peptide, hydrolyzed collagen, Hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat protein Degraded peptides, hydrolyzed wheat protein, casein-degraded peptides, acylated peptides and other protein peptides and their derivatives; palmitoyl oligopeptides , Acylated peptides such as palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, glutathione, albumin, milk Chin; choline chloride, phosphorylcholine; placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract, merirot extract Preferred are ceramides such as animal and plant extract components such as natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide, and sugar-ceramide-containing extracts. All It is.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acylamino acid salts such as sodium phosphate, triethanolamine cocoylglutamate, sodium lauroylglutamate, sodium myristoylglutamate, sodium stearoylglutamate, ditriethanolamine palmitoylaspartate, cocoylalaninetriethanolamine, lysine Nadilauroylglutamate; sodium laureth acetate, etc. Polyoxyethylene alkyl ether acetates; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; Fatty acid glyceride sulfate such as coconut oil fatty acid sodium glycerin sulfate; Oxyethylene sulfate; Olefin sulfonate such as sodium α-olefin sulfonate; Alkyl sulfosuccinate such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; Disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate Alkyl ether sulfosuccinates such as sodium acid, sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonate; alkanesulfonate; α-sulfo fatty acid methyl ester salt; acyl isethionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetates; alkyl ether phosphates such as sodium laureth phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate esters such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphorus Fatty acid amide ether phosphates; Phospholipids such as phosphatidylglycerol, phosphatidylinositol and phosphatidic acid; Silicone anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone and sulfuric acid-modified silicone; Among the ionic surfactants, laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether) ), Behenes (polyoxyethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether), octyldecesses (polyoxyethylene octyldodecyl ether), and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers Polyoxyethylene alkyl phenyl ether; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil Castor oil and hydrogenated castor oil derivatives such as monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polio Polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / poly Oxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; PPG-9 di (Poly) glycerin polyoxypropylene glycol such as glyceryl; glyceryl stearate, glyceryl isostearate, Glyceryl mycinate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-oleate pyroglutamate, glyceryl monostearate malate, etc. Glycerin fatty acid partial esters: polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl-6 distearate, 10, polyglyceryl tristearate, polyglyceryl decastearate -10, polyglyceryl isostearate 2, 3, 4, 5, 6, 8, 10, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 10, polyglyceryl triisostearate 2, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 8, dioleate polyglyceryl-6, trioleate polyglyceryl -2, polyglyceryl fatty acid ester such as polyglyceryl-10 dekaoleate; ethylene glycol mono fatty acid ester such as ethylene glycol monostearate; propylene glycol mono fatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid Maltitol partial fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbita Sorbitan fatty acid esters such as monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside Sugar ester partial esters such as fatty acid esters and undecylenic acid trehalose; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohols; reduced lanolins; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene mono Polyoxyethylene fatty acid mono- and diesters such as oleate and polyoxyethylene dioleate; polyoxyethylene propylene glycol Polyoxyethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol fatty acid esters such as polyoxyethylene monooleate such as polyoxyethylene glycerol triisostearate; polyoxyethylene Polyoxyethylene sorbitan fatty acid esters such as sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate Polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate, etc. Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable fats and oils such as polyoxyethylene sorbitol beeswax; Isostearyl glyceryl ether, chimyl alcohol, seraalkyl alcohol, batyl Alkyl glyceryl ethers such as alcohols; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acids Amides; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), la Phosphoric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamic acid MEA), palmitic acid diethanolamide (partamic acid DEA), coconut oil Fatty acid alkanolamides such as fatty acid methylethanolamide (cocamidomethyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkylmercaptan; Polyether-modified silicone such as dimethicone copolyol, polysiloxane-oxyalkylene copolymer, polyglycerin-modified silicone Silicone-based nonionic surfactants such as corn and sugar-modified silicone; and cationic surfactants such as alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; Alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines such as stearamidepropyldimethylamine and stearamideethyldiethylamine and salts thereof; stearoxypropyldimethyl Alkyl ether amines such as amines and salts or quaternary salts thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyl dimethyl Fatty acid amide type quaternary ammonium salts such as ruammonium and ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and salts or quaternary salts thereof; alkylamine salts; fatty acid amidoguanidinium salts; Alkyltrialkylene glycol ammonium salt; Benzalkonium salt; Benzethonium salt; Pyridinium salt such as cetylpyridinium chloride; Imidazolinium salt; Alkylisoquinolinium salt; Dialkyl morpholinium salt; Polyamine fatty acid derivative; Aminopropyl dimethicone And amino-modified silicone such as amodimethicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone Cationic surfactants, etc .; in amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryl dimethylaminoacetic acid betaine); cocamidopropyl betaine, lauramidopropyl betaine, etc. Fatty acid amide alkyl-N, N-dimethylamino acid betaines; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; alkyldimethylamino Phosphate betaines such as ethanol phosphates; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, water Phospholipids such as raw-added soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants; Preferable examples include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymers, and various silicone surfactants.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazoline derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzoyl chloride Luconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol , Photosensitizers, antibacterial zeolite, and silver ion are preferable, but when used as an antibacterial agent or antiseptic agent for antiseptic purposes, phenoxyethanol; 1 from the viewpoint of safety of cosmetics or skin external preparations; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.

  Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

  Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid-based UV absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone purple 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphsulfone Preference is given to acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

  Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

  As plant / animal / microbe extracts, Iris extract, Ashitaba extract, Asunaro extract, Asparagus extract, Avocado extract, Achacha extract, Almond extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Ginkgo biloba extract, Ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.

  As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Base dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4- Nitro dyes such as hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2 and Basic Blue 26; disperse dyes; inorganic white such as titanium dioxide and zinc oxide Pigments: Inorganic red pigments such as iron oxide (Bengara) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and loess; Black iron oxide, low-order titanium oxide, etc. Inorganic pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica; Titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil; aluminum powder, copper powder, gold, etc. Surface treated inorganic and metal powder pigments: Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204 No., Yellow 205, Yellow 401, Blue 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Organic pigments such as zirconium, barium or aluminum lake such as yellow 5, yellow 202, yellow 203, green 3 and blue 1; surface treatment organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene , Catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochini Natural pigments and dyes such as naphthoquinones such as ru and shikonin, bixin, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m- Oxidative dye intermediates and couplers such as p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; Oxidizing dyes; dihydroxyacetone is preferred.

  Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  Examples of the cosmetic or skin external preparation of the present invention include skin external preparations such as hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and ointments. From the viewpoint of exerting the effects of the present invention, it can be preferably used particularly for hair cosmetics and basic cosmetics. The cosmetic of the present invention can be produced according to a usual method.

  The cosmetic or skin external preparation of the present invention will be described in further detail. Examples of hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, and rinse-integrated shampoos. Rinsing, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow, split hair coat , Hair oil, permanent wave agent, straight permanent agent, oxidative hair dye, hair bleach, hair color pretreatment, hair color after treatment, permanent pretreatment, permare Terpolymers treatments, hair manicure, and as hair growth agents are preferred.

  Basic cosmetics include soft lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, Nourishing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; Liposome cosmetics such as liposomal serum and liposome lotion; packs and masks such as peel-off pack, powder pack, washing pack, oil pack, cleansing mask; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing gel Facial cleansers such as oils, cleansing masks, powders and facial cleansers; cosmetic soaps, transparent soaps, medicated soaps, liquid soaps, shaving soaps, synthetic cosmetic soaps Soap can be mentioned as preferred.

  As makeup cosmetics, white powder, dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment are preferable. .

  Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.

  Body cosmetics include body shampoos and other body cleansers, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics, depigmenting agents, depilation / hair removal agents, bathing agents, insect repellents, etc. A repeller is preferred.

  Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

  As the dosage form of the cosmetic or external preparation for skin of the present invention, emulsification such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type, etc. Type cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, pastes Preferred examples include cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

  The following examples further illustrate the present invention in detail but are not to be construed to limit the scope thereof.

<Storage stability of aqueous solution>
The aqueous solution which mix | blended tranexamic acid and phytic acid with the composition of Table 1, and adjusted pH to 7 vicinity with potassium hydroxide was produced (Examples 1-5). For comparison, an aqueous solution containing no phytic acid was prepared (Comparative Example 1). In addition, all the aqueous solutions immediately after preparation were melt | dissolving transparently. These aqueous solutions were stored at 25 ° C. for 1 week, and the appearance after storage was visually observed to confirm the presence or absence of crystal precipitation. Crystal precipitation was evaluated in the following three stages, and the results are shown in Table 1.

○ ... No crystal precipitation Δ: Slight crystal precipitation ×… Many crystal precipitations

  From the results of Table 1, it can be seen that the aqueous solution containing only tranexamic acid (Comparative Example 1) precipitated many crystals, whereas the aqueous solutions of Examples 1 to 5 combined with phytic acid had suppressed crystal precipitation. I understood.

<Inhibition of crystal precipitation after water evaporation (skin lotion)>
Toner lotion (Examples 6 to 9) containing tranexamic acid and phytic acid in the composition of Table 2 and lotion containing ingredients corresponding to tranexamic acid, phytic acid and component (C) in the composition of Table 3 (implementation) Examples 10-14) were prepared. For comparison, a lotion containing no phytic acid (Comparative Examples 2 and 3) was prepared. After 1.5 g of the prepared lotion was put in a petri dish having a diameter of 3.5 cm and allowed to stand at room temperature for 1 day to evaporate water, the presence or absence of crystal precipitation of tranexamic acid was visually confirmed. Crystal precipitation was evaluated in the following four stages, and the results are shown in Tables 2 and 3 together.

◎ ・ ・ ・ No crystal precipitation is observed ○ ・ ・ ・ Partial crystal precipitation is observed △ ・ ・ ・ Crystal precipitation is observed over the whole × ・ ・ ・ Crystal precipitation over the whole Can be seen

  From the results shown in Table 2, compared with the lotion containing only tranexamic acid (Comparative Example 2), the lotion containing the phytic acid (Examples 6 to 9) is suppressed from crystal precipitation after the water is evaporated. I found out. Moreover, from the result of Table 3, it was confirmed that crystal precipitation is further suppressed by further blending the component (C).

<Inhibition of crystal precipitation after water evaporation (cream)>
Creams (Examples 15 to 17) containing tranexamic acid and phytic acid in the composition of Table 4 and creams (Example 18) containing tranexamic acid, phytic acid and components corresponding to component (C) were prepared. . For comparison, a cream not containing phytic acid (Comparative Example 4) was prepared. 0.5 g of the prepared cream was put in a petri dish having a diameter of 3.5 cm and left at room temperature for 1 day to evaporate water. Since the cream after evaporation was cloudy, it was difficult to visually confirm crystal precipitation. Therefore, a preparation was prepared and observed with an optical microscope to confirm the presence or absence of crystal precipitation of tranexamic acid. Crystal precipitation was evaluated in the following four stages, and the results are shown in Table 4.

◎ ・ ・ ・ No crystal precipitation is observed ○ ・ ・ ・ Partial crystal precipitation is observed △ ・ ・ ・ Crystal precipitation is observed over the whole × ・ ・ ・ Crystal precipitation over the whole Can be seen

（調製方法）
Ｎｏ．１〜３を７０℃で攪拌し、均一に分散させた（Ａ部）。Ｎｏ．４〜５を７０℃で均一に攪拌混合した（Ｂ部）。Ｎｏ．６〜９を室温で均一に攪拌混合した（Ｃ部）。Ｎｏ．１０〜１１を７０℃で均一に攪拌混合した（Ｄ部）。ホモディスパーにて攪拌しながらＡ部にＢ部を加えた後、Ｄ部を加えて乳化した。約４０℃まで冷却した後、Ｃ部、を加えて攪拌した。

(Preparation method)
No. 1-3 were stirred at 70 ° C. and uniformly dispersed (part A). No. 4-5 was stirred and mixed uniformly at 70 ° C. (Part B). No. 6-9 were stirred and mixed uniformly at room temperature (part C). No. 10-11 were stirred and mixed uniformly at 70 ° C. (part D). After adding part B to part A while stirring with a homodisper, part D was added and emulsified. After cooling to about 40 ° C., part C was added and stirred.

  From the result of Table 4, compared with the cream (Comparative Example 4) which mix | blended only tranexamic acid, as for the cream (Examples 15-17) which used phytic acid together, the crystal | crystallization precipitation after a water | moisture content evaporated was suppressed. I found out. Further, it was confirmed that the cream (Example 18) in which the component (C) was further blended was further suppressed from crystal precipitation.

Example 19
A lotion having the following formulation was prepared. This lotion was one in which crystal precipitation of tranexamic acid was suppressed. This lotion had a moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Tranexamic acid 2.00
Phytic acid 0.30
Purified water 18.00
Part B 3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 0.10
Part C Arbutin 4.00
Dipropylene glycol 4.00
Absolute ethanol 5.00
Glycerin 5.00
Hyaluronic acid Na 0.20
Pyrosulfite Na 0.10
Phosphoric acid appropriate amount Dihydrogen phosphate Na appropriate amount Edetic acid diNa 0.10
Phenoxyethanol 0.30
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and dissolved uniformly. Part C was mixed and heated to about 70 ° C. to dissolve uniformly. Part C was cooled to 40 ° C., and parts A and B were mixed and made uniform.

Example 20 Lotion Toner lotion having the following formulation was prepared. This lotion was one in which crystal precipitation of tranexamic acid was suppressed. This lotion contains bisethoxydiglycol cyclohexanedicarboxylate (Neosolu-Aquilio: Nippon Seika) and promotes penetration of tranexamic acid. This lotion had a moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A 1,3-butylene glycol 4.00
Glycerin 2.00
Methylparaben 0.10
Part B Tranexamic acid 2.00
Phytic acid 0.10
Purified water 18.00
Part C Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolute-Aquilio: Nippon Seika) 0.50
Edetic acid di-Na 0.10
White jellyfish polysaccharide (Tremoist-SL: Nippon Seika) 5.00
Pyrosulfite Na 0.10
Phenoxyethanol 0.20
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A, part B and part C were taken and mixed uniformly. Part A and part B were added to part C to make it uniform.

Example 21 Gel A gel having the following formulation was prepared. This gel was one in which crystal precipitation of tranexamic acid was suppressed. This gel showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Tranexamic acid 2.00
Phytic acid 0.04
Purified water 18.00
Part B carboxyvinyl polymer 0.30
Purified water 15.00
Part C 1,3-butylene glycol 4.00
Glycerin 2.00
Methylparaben 0.15
Part D Edetic acid diNa 0.10
Phenoxyethanol 0.20
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and dissolved uniformly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and dissolved uniformly. After adding Part A and Part C to Part D and stirring, Part B was mixed and stirred to make it uniform.

Example 22 Emulsion An emulsion having the following formulation was prepared. This emulsion was one in which crystal precipitation of tranexamic acid was suppressed. This emulsion contains bisethoxydiglycol cyclohexanedicarboxylate (Neosol-Aquilio: Nippon Seikai) and promotes penetration of tranexamic acid. Moreover, this emulsion was an emulsion excellent in the effect which provides a moist feeling. This emulsion was a skin care cream having an appropriate viscosity, excellent spreadability, and a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl /
Behenyl) (Plandool-H: Nippon Seika) 1.00
N-lauroylmethyl-L-glutamate di (phytosteryl behenyl
2-octyldodecyl) (Plandool-LG1: Nippon Seika) 0.50
Glyceryl tri-2-ethylhexanoate (IOTG: Nippon Seika) 0.50
Hydrogenated palm oil 1.00
Stearyl alcohol 0.50
Behenyl alcohol 0.80
Lipophilic glyceryl monostearate 0.60
Self-emulsifying propylene glycol stearate 0.40
Polyoxyethylene glyceryl isostearate 0.40
Methyl polysiloxane 0.60
Ethyl paraoxybenzoate 0.10
Part B Carboxyvinyl polymer 0.20
Purified water 10.00
Part C Xanthan gum 0.06
Purified water 10.00
Part D White Jellyfish Polysaccharide (Tremoist-SL: Nippon Seika) 5.00
Part E Tranexamic acid 2.00
Phytic acid 0.04
Methyl paraoxybenzoate 0.10
Propylene glycol 2.00
Glycerin 1.00
Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosol-Aquorio: Nippon Seika) 1.00
Edetic acid di-Na 0.10
D-Panthetine-S-sulfonic acid Ca 0.02
Phenoxyethanol 0.10
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and heated to about 70 ° C. and dissolved uniformly. Part C was mixed and stirred to give a viscous liquid. Part E was mixed and dissolved uniformly. After adding E part to A part and stirring and emulsifying, it cooled and added B part, C part, and D part at about 50 degreeC, and it stirred and made it uniform.

Example 23 Cream A cream having the following formulation was prepared. In this cream, crystal precipitation of tranexamic acid was suppressed. This cream is mixed with bisethoxydiglycol (Neosolu-Aquilio: Nippon Seika), and promotes penetration of tranexamic acid. Moreover, this cream was excellent in the effect which provides a moist feeling. This cream was a skin care cream having an appropriate viscosity, excellent spread and a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A 2-Cetyl 2-ethylhexanoate (NS-CIO: Nippon Seika) 3.00
Glyceryl tri-2-ethylhexanoate (IOTG: Nippon Seika) 3.00
Palm kernel oil 2.50
Cetanol 1.20
Behenyl alcohol 1.70
Lipophilic glyceryl monostearate 1.80
Self-emulsifying propylene glycol stearate 1.00
Polyoxyethylene glyceryl isostearate 1.10
Methylpolysiloxane 1.50
Ethyl paraoxybenzoate 0.10
Part B Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolute-Aquilio: Nippon Seiki) 1.00
Methyl paraoxybenzoate 0.15
Taurine 0.10
1,3-butylene glycol 2.00
Glycerin 3.00
Edetic acid di-Na 0.10
Pyrosulfite Na 0.10
Purified water Total amount of 100 parts C Carboxyvinyl polymer 0.20
Purified water 20.00
Part D White Jellyfish Polysaccharide (Tremoist-SL: Nippon Seika) 5.00
Part E Tranexamic acid 2.00
Phytic acid 0.08
Purified water 18.00
--------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and heated to about 70 ° C. and dissolved uniformly. Part C was mixed and stirred to give a viscous liquid. Part E was mixed and dissolved uniformly. Part B was added to part A, stirred and emulsified, and then cooled and added at about 50 ° C., part C, part D and part E, and stirred to make uniform.

Example 24 Gel A gel having the following formulation was prepared. This gel was one in which crystal precipitation of tranexamic acid was suppressed. This gel showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A ethanol 5.00
Ethyl hexyl methoxycinnamate 0.01
BHT 0.01
1,3-butylene glycol 6.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 1.00
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.20
Hydrolyzed yeast extract 0.05
Hydroxyproline 0.20
Pentethic acid (diethylenetriaminepentaacetic acid) 0.06
Citric acid 0.05
Na citrate Appropriate amount Purified water Amount that will be 100 in total −
(Preparation method)
Part A was mixed and dissolved uniformly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part A and part C were added to part B and stirred to make uniform.

Example 25 Gel A gel having the following formulation was prepared. This gel was one in which crystal precipitation of tranexamic acid was suppressed. This gel showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Dipropylene glycol 1.00
1,3-butylene glycol 6.00
Phenoxyethanol 0.20
Methylparaben 0.15
Ethyl hexyl methoxycinnamate 0.01
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.40
Stearoxyhydroxypropylmethylcellulose 0.80
Purified water 20.00
Part C Tranexamic acid 1.00
Phytic acid 0.10
Betaine 0.05
Licorice extract 0.05
Alanylglutamine 0.05
Ethylenediaminetetraacetic acid di-Na 0.10
Hyaluronic acid Na 0.20
Citric acid 0.05
Na citrate Appropriate amount Purified water Amount that will be 100 in total −
(Preparation method)
Part A was mixed and dissolved uniformly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part A and part B were added to part C and stirred to make uniform.

Example 26 Gel A gel having the following formulation was prepared. This gel was one in which crystal precipitation of tranexamic acid was suppressed. This gel showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A PEG-30 0.01
Dipropylene glycol 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Part B (Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer
0.20
Carboxymethylcellulose Na 0.80
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.15
Betaine 0.05
Hydrolyzed white pepper seed extract 0.05
Sorbitol fermentation polysaccharide 0.05
Lactic acid 0.05
Lactic acid Na Appropriate amount Penteto acid (diethylenetriaminepentaacetic acid) 0.05
Polylysine 3.00
Trehalose 6.00
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and dissolved uniformly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part A and part B were added to part C and stirred to make uniform.

Example 27 Gel A gel having the following formulation was prepared. This gel was one in which crystal precipitation of tranexamic acid was suppressed. This gel showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Sorbitol 6.00
Diglycerin 1.00
Hydrogenated lecithin, phytosterol, coenzyme Q10 complex (Phytopresome-Q10: Nippon Seika) 0.30
Part B (Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer
0.20
Carboxymethylcellulose Na 0.80
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.03
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.10
3-O-ethylascorbic acid 0.20
Olive leaf extract 0.05
Maronier extract 0.05
Glycosyl trehalose 0.05
Fumaric acid 0.05
Sodium fumarate appropriate amount HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.15
Warmoko extract 0.20
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. Part C was added to part A, stirred with a homomixer, uniformly dissolved, cooled, and part B was added at about 50 ° C. to make it uniform.

Example 28 Emulsion An emulsion having the following formulation was prepared. This emulsion was one in which crystal precipitation of tranexamic acid was suppressed. This emulsion showed an appropriate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Setanol 0.20
Squalane 0.05
Soybean oil 0.05
Behenez-30 0.05
Ethylhexyl methoxycinnamate 0.05
Tocopherol 0.05
Part B Carboxymethylcellulose Na 0.40
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.10
Chondroitin sulfate Na 0.20
HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.01
Hyaluronic acid Na 0.03
Sorbitol 6.00
Succinic acid 0.03
Sodium succinate appropriate amount diglycerin 0.15
Sohakuhi extract 0.20
Loquat leaf extract 0.15
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. C part was added to A part, stirred and emulsified, then cooled and added at about 50 ° C., and B part was added and stirred to be uniform.

Example 29 Cream A cream having the following formulation was prepared. In this cream, crystal precipitation of tranexamic acid was suppressed. This cream showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Batyl alcohol 2.00
Squalane 2.00
Glyceryl tri-2-ethylhexanoate 3.00
Stearic acid 1.00
Macadamia nut oil fatty acid phytosteryl (Plandool-MAS: Nippon Seika) 1.00
Natural vitamin E 0.05
Behenyl alcohol 2.00
Lipophilic glyceryl monostearate1.00
Ethylparaben 0.15
Methyl polysiloxane 0.50
Polyoxyethylene cetyl ether 2.00
Hydrogenated lecithin, phytosterol complex (Phytocompo-PP: Nippon Seika) 1.00
Part B Carboxyvinyl polymer 0.20
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Gluconic acid 0.10
Succinic acid 0.01
Sodium succinate appropriate amount 1,3-butylene glycol 0.15
Sohakuhi extract 0.20
Hydroxyethane diphosphonic acid solution (60%) 0.10
Concentrated glycerin 0.20
Inositol 0.10
Methylparaben 0.10
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. C part was added to A part, stirred and emulsified, then cooled and added at about 50 ° C., and B part was added and stirred to be uniform.

Example 30 Cream A cream having the following formulation was prepared. In this cream, crystal precipitation of tranexamic acid was suppressed. This cream showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A jojoba oil 2.00
Dimerlinoleic acid (phytosteryl / isostearyl / cetyl / stearyl /
Behenyl) (Plandool-H: Nippon Seika) 1.00
PEG-60 glyceryl isostearate 0.70
Macadamia nut oil fatty acid phytosteryl 1.00
Propylene glycol monostearate 0.60
Behenyl alcohol 1.20
Self-emulsifying glyceryl monostearate 1.20
Ethylparaben 0.15
Methylpolysiloxane 1.00
Polyoxyethylene cetyl ether 2.00
Part B Carboxymethylcellulose Na 0.20
(Acryloyldimethyltaurine / Beheneth-25 methacrylate) polymer
0.30
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.05
Quince Seed Extract 0.05
Citric acid appropriate amount Na citrate appropriate amount 1,3-butylene glycol 0.15
Sohakuhi extract 0.20
Ethylenediaminetetraacetic acid di-Na 0.10
Concentrated glycerin 2.00
Methylparaben 0.10
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. C part was added to A part, stirred and emulsified, then cooled and added at about 50 ° C., and B part was added and stirred to be uniform.

Example 31 Emollient Cream An emollient cream having the following formulation was prepared. In this emollient cream, crystal precipitation of tranexamic acid was suppressed. This emollient cream was an emollient cream exhibiting an appropriate viscosity, excellent in spreading, and having a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Lauroyl glutamate di (phytosteryl / octyldodecyl)
(Plandool-LG2: Nippon Seika) 1.00
Dimer dilinoleic acid dimer dilinoleyl (LUSPLAN DD-DA5: Nippon Seika) 1.00
Hydrogenated palm oil 2.50
Behenyl alcohol 2.00
Dimethicone (10cs) 1.50
Glyceryl stearate 1.50
Stearyl alcohol 1.20
Stearic acid PG (SE) 1.00
PEG-60 glyceryl isostearate 1.00
Ethyl hexyl methoxycinnamate 0.20
Ethylparaben 0.10
Part B Carboxymethylcellulose Na 0.30
Acrylic acid alkyl methacrylate copolymer 0.30
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.20
1,3-butylene glycol 6.00
Ethylenediamine disuccinic acid 3Na 0.30
Pentethic acid (diethylenetriaminepentaacetic acid) 0.05
Fumaric acid appropriate amount Fumarate Na appropriate amount Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. After adding C part to A part and emulsifying with a homomixer, it cooled and added B part at about 50 degreeC, and it stirred and made it uniform.

Example 32 Sunscreen Agent A sunscreen agent having the following formulation was prepared. This sunscreen agent was one in which crystal precipitation of tranexamic acid was suppressed. This sunscreen exhibited an appropriate viscosity, was excellent in spreading, and had a good UV protection ability.

Component Blending amount (% by weight)
--------------------------------------
Part A Squalane 22.50
Dimer dilinoleic acid di (isostearyl / phytosteryl)
(LUSPLAN PI-DA: Nippon Seika) 2.70
Microcrystalline wax 2.70
Distearate Al 1.60
Mg stearate 1.60
1,3-butylene glycol 5.00
Behenyl alcohol 4.80
Hydrogenated lecithin, cholesterol complex (Composite-PC: Nippon Seika) 1.00
Cholesterol 0.80
Propylparaben 0.20
Part B Alkyl methacrylate alkyl copolymer 0.30
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.30
Pentethic acid (diethylenetriaminepentaacetic acid) 0.10
Appropriate amount of succinic acid Appropriate amount of sodium succinate Purified water 20.00
Part D Methylparaben 0.20
Titanium oxide 9.00
Magnesium sulfate 0.50
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was added and kneaded with a mill. Part B was added to a separate container and heated to about 80 ° C. and dissolved. Part C was added to another container and heated to about 80 ° C. and dissolved. Part D was added to a separate container and heated to about 80 ° C. and dissolved. Part C was added to part B, mixed, and then added to part A and mixed uniformly. Subsequently, D part was added and made uniform.

Example 33 Base Cream A base cream having the following formulation was prepared. This base cream was one in which crystal precipitation of tranexamic acid was suppressed. This whitening base cream was a base cream having an appropriate viscosity, excellent spreading, and covering power.

Component Blending amount (% by weight)
--------------------------------------
Part A Cyclomethicone 15.00
Trimethylsiloxysilicate 3.00
Glyceryl stearate (SE) 2.00
Stearic acid PG (SE) 2.00
Macadamia nut fatty acid phytosteryl (Plandool-MAS: Nippon Seika) 2.00
Stearic acid 0.50
Palmitic acid 0.50
Ethyl hexyl methoxycinnamate 0.50
Tocopherol 0.20
Part B Carboxymethylcellulose Na 0.10
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Purified water 18.00
Part D 1,3-butylene glycol 10.00
Mica 8.00
Talc 7.00
Phenoxyethanol 0.80
Titanate (Li / Cobalt) 0.20
Xanthan gum (10%) 2.00
Cellulose gum (10%) 2.00
Glutamic acid diacetate 4Na 0.80
Pentethic acid (diethylenetriaminepentaacetic acid) 0.05
Lactic acid Appropriate amount Sodium lactate Appropriate amount Purified water Total amount of 100 ------------------------------ −−
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added about B part and C part at about 50 degreeC, and it was made uniform.

Example 34 Massage cream A massage cream having the following formulation was prepared. This massage cream was one in which crystal precipitation of tranexamic acid was suppressed. This massage cream was a massage cream having a high massage effect, an appropriate viscosity, excellent spreading, and a moisturizing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Macadamia Nuts Fatty Acid Phytosteryl (Plandool-MAS: Nippon Seika) 8.00
Glyceryl stearate (SE) 2.00
Polysorbate 60 1.80
Sorbitan stearate 1.00
Polyglyceryl stearate-10 0.50
Cholesterol 0.20
Dimethicone (10cs) 1.00
Myristyl alcohol 1.00
Stearic acid 1.00
Stearyl alcohol 0.50
Behenyl alcohol 0.50
Hydrogenated palm oil 9.00
Tocopherol 0.10
Isostearyl palmitate 2.00
Cetyl ethylhexanoate 15.00
Ethylparaben 0.20
Part B carboxyvinyl polymer 0.30
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Purified water 18.00
Part D Phenoxyethanol 0.20
Methylparaben 0.10
HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.20
Fumaric acid 0.05
Sodium fumarate appropriate amount Salicylic acid 0.02
1,3-butylene glycol 10.00
Glycerin 3.00
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it was made uniform.

Example 35 Emulsion An emulsion having the following formulation was prepared. This emulsion was one in which crystal precipitation of tranexamic acid was suppressed. This emulsion showed an appropriate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A sorbitan stearate 0.50
PEG-10 stearate 0.50
Polysorbate 60 0.50
Phytosteryl isostearate (Plandool-ISS: Nippon Seika) 1.00
Cetyl ethylhexanoate 3.70
Cetanol 1.20
Dimethicone (10cs) 1.00
1,2-hexanediol / caprylyl glycol 0.50
Ethylparaben 0.10
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.05
Stearoxyhydroxypropylmethylcellulose 0.10
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Purified water 18.00
Part D 1,3-butylene glycol 3.00
(Eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Hydroxyethane diphosphonic acid solution (60%) 0.05
Citric acid 0.01
Na citrate 0.09
Xanthan gum 0.10
Carboxyvinyl polymer 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it was made uniform.

Example 36 Liquid Foundation A liquid foundation having the following formulation was prepared. In this liquid foundation, crystal precipitation of tranexamic acid was suppressed. This liquid foundation was excellent in usability and adhesion to the skin, showed an appropriate viscosity, and was excellent in spreading.

Component Blending amount (% by weight)
--------------------------------------
Part A Glyceryl stearate (SE) 1.00
Stearic acid PG (SE) 1.00
Cetyl octanoate 6.00
Tocopherol 0.10
Propylparaben 0.10
Titanium oxide / iron oxide mixture (FDP-W-007 manufactured by Toyo Pigment Co., Ltd.) 18.00
Mica 7.00
Trimethylsiloxysilicate 3.00
Cyclomethicone 7.00
Phenylmethicone 5.00
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.20
Carboxymethylcellulose Na 0.05
(Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer
0.15
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Succinic acid 0.05
Sodium succinate appropriate amount Purified water 18.00
Part D Cellulose gum 0.10
Xanthan gum 0.20
Hydroxyethane diphosphonic acid solution (60%) 0.05
Glutamic acid diacetate 4Na 1.20
1,3-butylene glycol 5.00
Pentylene glycol 3.00
Methylparaben 0.05
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it was made uniform.

Example 37 Anti-aging cream An anti-aging cream having the following formulation was prepared. In this anti-aging cream, crystal precipitation of tranexamic acid was suppressed. This anti-aging cream was a cream with good elongation and excellent moisturizing effect, an appropriate viscosity, excellent spread, and a penetrating feel.

Component Blending amount (% by weight)
---------------------------------------
Part A Ethylhexanoate Cetyl 7.00
Batyl isostearate 2.00
PEG-60 glyceryl isostearate 1.50
Hydrogenated palm oil 3.70
Ceramide 2 0.10
Retinol 0.10
Oil-soluble chamomile extract 0.10
Ethylparaben 0.20
Stearyl alcohol 3.50
Glyceryl stearate (SE) 1.00
Steerless-6 1.50
Distearic acid PEG-8 1.00
Cetanol 1.00
Dimethicone 1.00
Cetyl dimethicone copolyol 0.50
Tocopherol 0.20
Part B (Ammonium acryloyldimethyltaurate / VP) copolymer 0.10
Carboxymethylcellulose Na 0.05
(Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer
0.15
Purified water 20.00
Part C Nishigayu extract 0.05
Tranexamic acid 2.00
Phytic acid 0.04
Purified water 18.00
Part D Arbutin 0.50
Ascorbic acid 2-O-glucoside 0.50
EDTA-3Na 0.10
Polyglutamic acid 0.10
(Eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
Glycerin 4.00
Bisulfite Na 0.05
Lactic acid 0.05
Lactic acid Na proper amount Na propionate 0.02
Methylparaben 0.05
Phenoxyethanol 0.10
1,3-butylene glycol 6.00
Purified water Total amount of 100 ---------------------------------------
(Production method)
Part A was heated to about 80 ° C. and dissolved uniformly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was heated to about 80 ° C. and dissolved. While stirring with a homomixer at about 80 ° C., part A was gradually added, emulsified and mixed uniformly, cooled to about 40 ° C., and parts B and C were added to make uniform.

Example 38 Sunscreen Cosmetic A sunscreen cosmetic having the following formulation was prepared. In this sunscreen cosmetic, crystal precipitation of tranexamic acid was suppressed. This sunscreen cosmetic did not float white and had a high UV protection effect. Furthermore, it was a sunscreen cosmetic that showed an appropriate viscosity and was excellent in spreading.

Component Blending amount (% by weight)
--------------------------------------
Part A Quotanium-18 Hectorite 1.00
Part B Cyclomethicone 13.70
Diphenyl dimethicone 7.00
Dimethicone copolyol 5.50
Macadamia nut fatty acid phytosteryl (Plandool-MAS: Nippon Seika) 1.00
Part C Silicone-treated fine particle titanium oxide 3.90
Silicone-treated zinc oxide 2.10
D part Al stearate 0.70
Hydroxide Al 0.50
Isononyl isononanoate 2.50
Isodecyl neopentanoate 2.50
Part E Trimethylsiloxysilicate 1.20
Dimethicone 0.80
Meticon 0.10
Stearyl glycyrrhetinate 0.02
Sorbitan sesquioleate 2.00
Tocopherol 0.02
Part F Tranexamic acid 2.00
Phytic acid 0.04
(Acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Na chloride 1.00
Hydroxyethane diphosphonic acid solution (60%) 0.07
Lactic acid 0.05
Lactic acid Na appropriate amount Hyaluronic acid Na 0.20
Isopropyl methylphenol 0.05
EDTA-3Na 0.10
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Production method)
Add Part A to Part B and stir. Add part C and disperse using a roller mill. Part D is heated and melted and added to the mixture of Part A, Part B and Part C, and further Part E is added to about 70 ° C. Part F is heated and gradually emulsified with stirring into the mixture from Part A to Part E.

Example 39 Moisturizing lotion A moisturizing lotion having the following formulation was prepared. This moisturizing lotion was one in which crystal precipitation of tranexamic acid was suppressed. This moisturizing lotion was excellent in the feeling of use and moisturizing, kept the skin soft and fresh and smooth and moisturized, and these effects lasted for a long time. This moisturizing lotion was a whitening moisturizing lotion having an appropriate viscosity, excellent spread and a feeling of penetration.

Component Blending amount (% by weight)
--------------------------------------
Part A (acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Carboxymethylcellulose Na 0.20
Purified water 20.00
Part B Tranexamic acid 2.00
Phytic acid 0.04
Purified water 18.00
Part C (Eicosanedioic acid / Tetradecanedioic acid) Polyglyceryl-10 1.00
1,3-butylene glycol 1.00
Glycerin 2.00
Citric acid 0.01
Sodium citrate appropriate amount ubiquinone 0.03
Glyceryl tri-2-ethylhexanoate (IOTG: Nippon Seika) 0.03
Tetraoleic acid Solves-60 0.12
PEG-60 hydrogenated castor oil 0.03
PEG-30 glyceryl isostearate 0.03
Hydroxyethane diphosphonic acid solution (60%) 0.03
Methylparaben 0.20
Fragrance Trace amount Ethanol 7.00
Triclosan 0.05
Glutamic acid diacetate 4Na 0.80
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and stirred to give a viscous liquid. Part B was mixed and dissolved uniformly. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. The mixture was cooled, and A and B parts were added to C part at about 50 ° C. and stirred to make it uniform.

Example 40 Hand Cream A hand cream having the following formulation was prepared. This hand cream was one in which crystal precipitation of tranexamic acid was suppressed. This hand cream was non-sticky and water-repellent hand cream. Moreover, it was a hand cream which showed moderate viscosity and was excellent in spreading.

Component Blending amount (% by weight)
--------------------------------------
Part A Dimerlinoleic acid dimerlinoleyl bis (behenyl / isostearyl /
Phytosteryl) (Plandool-G: Nippon Seika) 0.30
Hydrogenated lecithin 1.00
Behenyl alcohol 2.50
Cetyl 2-ethylhexanoate (NS-CIO: Nippon Seika) 3.00
Propylparaben 0.20
Dimethicone 4.00
Part B stearoxyhydroxypropylmethylcellulose 0.20
Acrylic acid alkyl methacrylate copolymer 0.50
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Purified water 18.00
Part D 1,3-butylene glycol 5.00
Methylparaben 0.20
Butylcarbamate propynyl iodide 0.02
Ethylenediaminetetraacetic acid 0.10
Xanthan gum (2% aqueous solution) 15.00
Fumaric acid 0.01
Sodium fumarate Appropriate amount Purified water Total amount to be 100 ---------------------------------- −
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. After adding C part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it was made uniform.

Example 41 Pre-shave lotion A pre-shave lotion having the following formulation was prepared. In this pre-shave lotion, crystal precipitation of tranexamic acid was suppressed. This pre-shave lotion has the effect of making the skin smooth. Furthermore, it was a pre-shave lotion exhibiting an appropriate viscosity and excellent in spreading.

Component Blending amount (% by weight)
--------------------------------------
Part A Tranexamic acid 2.00
Phytic acid 0.04
Citric acid 0.05
Zinc phenol sulfonate 0.20
Carboxymethylcellulose Na 0.10
(Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer
0.10
PEG-60 hydrogenated castor oil 0.10
Ethylenediaminetetraacetic acid di-Na 0.10
Glycyrrhizic acid 2K 0.05
Succinic acid 0.05
Sodium succinate Appropriate amount Purified water Amount to be 100 in total Part B Ethanol 30.00
Tocopherol 0.01
Triclocarban 0.02
Methylparaben 0.15
--------------------------------------
(Preparation method)
Both part A and part B were dissolved at room temperature, and part B was gradually added to part A while stirring to make it uniform.

Example 42 Carmine lotion A carmine lotion having the following formulation was prepared. This carmine lotion was one in which crystal precipitation of tranexamic acid was suppressed. This carmine lotion has the effect of making the skin smooth. This carmine lotion was a carmine lotion having an appropriate viscosity, excellent spreading, and a smooth feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Calamine 0.40
Kaolin 4.00
Mg carbonate 0.10
Purified water 20.00
Part B Alkyl methacrylate alkyl copolymer 0.30
(Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer
0.05
1,3-butylene glycol 2.00
Hydroxyethyl ethylenediamine triacetic acid 0.15
Allantoin 0.10
Citric acid 0.05
Sodium citrate appropriate amount Hinokitiol 0.02
Tranexamic acid 2.00
Phytic acid 0.04
Purified water Total amount of 100 parts C Ethanol 20.00
Canful 0.05
Methylparaben 0.20
--------------------------------------
(Preparation method)
Part A is dispersed. Both part B and part C were dissolved at room temperature, and part C was gradually added to part B with stirring, and further, part A was gradually added while stirring to make it uniform.

Example 43 Deodorant Lotion A deodorant lotion having the following formulation was prepared. This deodorant lotion was one in which crystal precipitation of tranexamic acid was suppressed. This deodorant lotion has the effect of making the skin smoother. This deodorant lotion was a deodorant lotion having an appropriate viscosity, excellent in spreading and refreshing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Purified water Total amount of 100 (styrene / DVB) copolymer 0.20
Tea dry distillation solution 0.50
Benzalkonium chloride 0.05
Na chloride 0.10
Carboxymethyl chitin 0.02
Alkyl methacrylate methacrylate copolymer 0.10
Hydroxyethane diphosphonic acid solution (60%) 0.05
Hydrochloric acid 0.01
Sodium hydroxide appropriate amount Tranexamic acid 2.00
Phytic acid 1.00
Part B Denatured alcohol 50.00
Methylparaben 0.20
--------------------------------------
(Preparation method)
Both part A and part B were dissolved at room temperature, and part B was gradually added to part A while stirring to make it uniform.

Example 44 Deodorant (Antiperspirant)
A deodorant (antiperspirant) having the following formulation was prepared. This deodorant (antiperspirant) was one in which crystal precipitation of tranexamic acid was suppressed. This deodorant has the effect of making the skin smoother. This deodorant was a deodorant that exhibited an appropriate viscosity, was excellent in spreading, and had a refreshing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Purified water Total amount to be 100 Tranexamic acid 2.00
Phytic acid 0.80
(Acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Stearoxyhydroxypropylmethylcellulose 0.20
(Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer
0.30
Methylparaben 0.10
Na chloride 0.01
Citric acid 0.05
Sodium citrate appropriate amount Hydroxyethane diphosphonic acid solution (60%) 0.10
Laureth-21 0.10
Benzalkonium chloride 0.05
Chlorhydroxyaluminum 0.20
White jellyfish polysaccharide (Tremoist-SL: Nippon Seika) 5.00
Part B Denatured alcohol 40.00
Propylparaben 0.10
Isopropyl methylphenol 0.50
--------------------------------------
(Preparation method)
Both part A and part B were dissolved at room temperature, and part B was gradually added to part A while stirring to make it uniform.

Example 45 Moisture Pack A moisture pack having the following formulation was prepared. In this moisture pack, crystal precipitation of tranexamic acid was suppressed. This moist chair pack enhances the moisturizing effect, softens the skin, gives a moist feeling and provides an excellent cleaning action. In addition, it was a moisture pack with an appropriate viscosity, excellent spread and moisturizing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A polyvinyl alcohol 13.00
Acryloyldimethyltaurine ammonium / VP) copolymer 0.80
Stearoxyhydroxypropylmethylcellulose 2.00
Alginate Na 0.50
1,3-butylene glycol 3.00
Alginic acid K 0.50
(Styrene / Vinylpyrrolidone) Copolymer 1.50
B part dimer dilinoleic acid dimer dilinoleyl bis (behenyl / isostearyl /
Phytosteryl) (Plandool-G: Nippon Seika) 0.30
Tranexamic acid 2.00
Phytic acid 0.04
PCA Glyceres-25 isostearate-25 1.50
Denatured alcohol 8.00
PEG / PPG-5 / 30 copolymer 1.00
Ores-10 phosphate DEA 1.00
Glycyrrhizic acid 2K 0.05
Tocopherol 0.10
Methylparaben 0.20
Hyaluronic acid Na 0.05
Na chloride 0.30
Hydroxyethyl ethylenediamine triacetic acid 0.20
Ethylhexyl glycerin 0.02
Fumaric acid 0.05
Sodium fumarate Appropriate amount Purified water Total amount to be 100 ---------------------------------- −
(Preparation method)
Part A is heated and swollen at 50 ° C. Gradually add part B to part A with stirring and mix uniformly.

Example 46 Lotion Toner lotion having the following formulation was prepared. This lotion was one in which crystal precipitation of tranexamic acid was suppressed. This skin lotion was not sticky, gave a moist feeling, and was excellent in familiarity with the skin. This whitening lotion had a moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Tranexamic acid 2.00
Phytic acid 0.10
(Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer
0.02
Carboxymethylcellulose Na 0.05
Succinoglucan 0.03
Purified water 20.00
Part B Dipropylene glycol 2.00
1,3-butylene glycol 2.00
Citric acid 0.10
Sodium citrate appropriate amount ethanol 8.00
Phenoxyethanol 0.20
Photosensitive Element 301 0.01
Methylparaben 0.10
EDTA-2Na 0.10
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and stirred to give a viscous liquid. Part B was mixed and dissolved uniformly. Part A was added to part B and stirred to dissolve uniformly.

Example 47 Cosmetic liquid A cosmetic liquid having the following formulation was prepared. This cosmetic liquid was one in which crystal precipitation of tranexamic acid was suppressed. This essence had a smooth feel while softening the skin and keeping the skin fresh and smooth. This whitening serum had an appropriate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A (acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Hyaluronic acid Na 0.40
Acrylic acid alkyl methacrylate copolymer 0.30
Purified water 20.00
Part B Tranexamic acid 2.00
Phytic acid 0.20
Purified water 18.00
Part C Glycyrrhizic acid 2K 0.10
Dipropylene glycol 2.00
1,3-butylene glycol 5.00
Succinic acid 0.05
Sodium succinate appropriate amount White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.20
Ethanol 5.00
Phenoxyethanol 0.20
Methylparaben 0.10
Hydroxyethane diphosphonic acid solution (60%) 0.07
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and stirred to give a viscous liquid. Part B was mixed and dissolved uniformly. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. The mixture was cooled, and A and B parts were added to C part at about 50 ° C. and stirred to make it uniform.

Example 48 Skin Care Cream A skin care cream having the following formulation was prepared. In this skin care cream, crystal precipitation of tranexamic acid was suppressed. This skin care cream was a cream with excellent moisturizing effect. This skin care cream was a skin care cream having an appropriate viscosity, excellent spreadability and a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Arbutin 3.00
Glycerin 3.00
Squalane 3.00
Jojoba oil 3.00
Palm kernel oil 3.10
Glyceryl stearate 2.30
PEG-60 glyceryl isostearate 1.40
Stearic acid PG (SE) 1.30
Stearyl alcohol 3.00
Behenyl alcohol 2.00
Dimethicone 1.50
Sunflower seed oil fatty acid phytosteryl (Plandool-SUN: Nippon Seika) 1.00
Ethylparaben 0.10
Part B stearoxyhydroxypropylmethylcellulose 0.20
Pullulan 0.50
Acrylic acid alkyl methacrylate copolymer 0.30
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.05
Purified water 18.00
Part D Methylparaben 0.15
Hydroxyethane diphosphonic acid solution (60%) 0.08
Citric acid 0.01
Na citrate Appropriate amount Purified water Amount that will be 100 in total −
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it was made uniform.

Example 49 Oil-in Lotion An oil-in lotion having the following formulation was prepared. In this oil lotion, crystal precipitation of tranexamic acid was suppressed. This oil lotion was a lotion that was excellent in the effect of imparting a moist feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Hydrogenated lecithin (Phytocompo-SP: Nippon Seika) 1.00
Glycerin 10.00
1,3-butylene glycol 3.00
B part dimer dilinoleic acid dimer dilinoleyl bis (behenyl / isostearyl /
Phytosteryl) (Plandool-G: Nippon Seika) 0.10
Glyceryl tri-2-ethylhexanoate (IOTG: Nippon Seika) 0.30
Squalane 0.30
Cetanol 0.30
Dimethicone 0.20
Methyl Gluces-10 3.00
Part C White Jellyfish Polysaccharide (Tremoist-SL: Nippon Seika) 3.00
(Acrylates / alkyl acrylate (C10-30)) cross polymer
0.06
Hydroxide K appropriate amount Purified water 20.00
Part D Propylene glycol 5.00
Phenoxyethanol 0.20
Methylparaben 0.10
Tranexamic acid 2.00
Phytic acid 0.04
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and heated to about 70 ° C. and dissolved uniformly. Part C was mixed and stirred to give a viscous liquid. Add Part C to Part A, stir and add Part D. After cooling, at about 50 ° C., part B was added and stirred until uniform.

Claims (3)

Cosmetic or skin external preparation containing the following components (A) and (B).
(A) tranexamic acid or a derivative thereof or a salt thereof (B) phytic acid or a salt thereof   The cosmetic or skin external preparation according to claim 1, wherein the component (B) is blended 0.001 times or more by weight with respect to the component (A). Furthermore, as a component (C), 1 type or 2 or more types selected from a carboxy vinyl polymer, an acrylic acid alkyl methacrylate copolymer, a hyaluronic acid, a carboxymethylcellulose, and a white jellyfish polysaccharide are described in Claim 1 or 2. Cosmetic or topical skin preparation.