JP2018024639A - Cosmetic composition comprising mannosylerythritol lipid - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic which forms vesicles with a small particle diameter containing a mannosylerythritol lipid and has transparency in appearance and excellent stability with time.SOLUTION: There is provided a cosmetic composition which comprises the following components (A) to (C), wherein the weight ratio between the component (A) and the component (B) is 9:1 to 6:4, the total of the contents of the component (A) and the component (B) is 2 to 30 wt.% and the content of the component (C) is 70 to 98 wt.%: (A) a mannosylerythritol lipid, (B) a phospholipid and (C) a polyhydric alcohol.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a cosmetic composition containing mannosyl erythritol lipid (hereinafter sometimes simply referred to as MEL), and a cosmetic using the cosmetic composition.

  The stratum corneum is present in the outermost layer of the skin and has an important function of preventing foreign substances and irritation from the outside. On the other hand, this barrier function suggests that it prevents the penetration of active ingredients in the use of cosmetics and skin external preparations. From such a viewpoint, attempts have been made to improve the permeability by encapsulating the active ingredient in a capsule such as a liposome. At this time, the smaller the particle diameter of the capsule, the more advantageous the improvement of the permeability.

  Glycolipid biosurfactants are produced by bacteria and yeast, and many types of substances have been reported. Such a glycolipid biosurfactant is not only highly biodegradable, low in toxicity and environmentally friendly, but also has excellent physiological functions. Mannosyl erythritol lipid (MEL) is known as one of typical glycolipid biosurfactants. MEL is very useful as an active ingredient of cosmetics and skin external preparations because it has physiological activities such as improvement of rough skin, anti-inflammation / anti-allergy, hair restoration and hair growth (for example, Patent Documents 1 to 3).

  Patent Document 4 describes that MEL itself forms vesicles, but the particle diameter when dispersed in water has not been studied. Patent Document 5 discloses a liposome composed of MEL and phospholipid. According to this patent, preparation of liposome requires a procedure of dissolving MEL and phospholipid in ethanol and removing ethanol under reduced pressure. is there. Patent Document 6 describes an oil-in-water emulsified cosmetic composition containing MEL, phospholipid, polyhydric alcohol and water, and describes that this emulsified composition can form a vesicle structure. However, the examples of this patent only describe examples of emulsions using hydroxylated lecithin as the phospholipid. Moreover, the particle diameter of the obtained emulsified composition is 200 nm or more, and it has not been confirmed whether the emulsified particles form vesicles. In addition, paragraphs 0110 to 0111 of this patent state that a high-pressure emulsifier is necessary for the formation of vesicles.

Table 2007-060956 JP 2005-068015 A JP 2003-261424 A JP 2009-154121 A JP 2005-281146 A JP 2009-275017 A

  As a subject of the present invention, firstly, a vesicle containing MEL is formed, the particle size of the vesicle is small, the appearance is transparent, and a cosmetic with excellent temporal stability is provided. . In addition, to solve this problem, it is also possible to use phospholipids that are as safe and environmentally friendly as biosurfactants, and that vesicles can be easily produced without the need for complicated operations and special machines such as high-pressure emulsifiers. It is mentioned as a subject of invention.

As a result of intensive studies to solve the above problems, the present inventors consist of the following components (A) to (C), and the weight ratio of the components (A) and (B) is 9: 1 to 6: 4, the total content of component (A) and component (B) is 2 to 30% by weight, and the content of component (C) is 70 to 98% by weight The present inventors have found that the above-mentioned problems can be solved by using a composition for foods, and have completed the present invention.

(A) Mannosylerythritol lipid having a structure represented by the following general formula (1)
(In the formula, R1 and R2 represent hydrogen or an aliphatic acyl group having 2 to 24 carbon atoms (but do not take hydrogen at the same time), R3 and R4 represent hydrogen or an acetyl group, and R5 represents hydrogen or carbon number. Represents 2 to 24 aliphatic acyl groups.)
(B) Phospholipid (C) Polyhydric alcohol

  The cosmetic composition of the present invention has a MEL-containing vesicle having a particle diameter of 100 nm or less formed by a simple operation of dispersing in water with low stirring force, and the appearance of the resulting cosmetic is transparent, Excellent stability over time.

The component (A) mannosyl erythritol lipid used in the present invention is a compound represented by the following general formula (1).
(In the formula, R1 and R2 represent hydrogen or an aliphatic acyl group having 2 to 24 carbon atoms (but do not take hydrogen at the same time), R3 and R4 represent hydrogen or an acetyl group, and R5 represents hydrogen or carbon number. Represents 2 to 24 aliphatic acyl groups.)

  R1, R2, and R5 in the general formula (1) are not particularly limited as long as they are aliphatic acyl groups having 2 to 24 carbon atoms, but are preferably saturated or unsaturated acyl groups having 6 to 20 carbon atoms. .

  The mannosyl erythritol lipid of the general formula (1) includes various compounds depending on the binding position of the acyl group or acetyl group, but generally four types of MEL-A, MEL-B, MEL-C and MEL-D are available. Widely known. MEL-A is a compound in which R1 and R2 in the general formula (1) are acyl groups, R3 and R4 are acetyl groups, and R5 is hydrogen. MEL-B is a compound in which R1 and R2 in the general formula (1) are acyl groups, R3 is hydrogen, R4 is an acetyl group, and R5 is hydrogen. MEL-C is a compound in which R1 and R2 in the general formula (1) are acyl groups, R3 is an acetyl group, R4 is hydrogen, and R5 is hydrogen. MEL-D is a compound in which R1 and R2 in the general formula (1) are acyl groups, R3 and R4 are hydrogen, and R5 is hydrogen. Any of these can be used in the present invention, but MEL-B or MEL-C is preferable and MEL-B is most preferable in terms of availability and effects of the invention.

  There is no restriction | limiting in particular in the manufacturing method of mannosyl erythritol lipid, It can manufacture by a well-known manufacturing method. In general, a fermentation method using a microorganism is known, and for example, it may be produced by a method described in JP-A-2009-275017.

  Component (B) phospholipid used in the present invention includes diacylglycerophospholipids having polar groups such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidic acid; soybean, rapeseed, sunflower, safflower, peanut Examples thereof include natural lecithin obtained from plants such as cottonseed, corn, rice and barley and egg yolk, and hydrogenated products thereof. Furthermore, these may be derivatives modified with a polyoxyalkylene group such as polyethylene glycol. These phospholipids may be used alone or in combination of two or more. Among these, natural lecithin and hydrogenated products thereof are preferable from the viewpoint of obtaining availability and the effects of the present invention. As natural lecithin, those having different contents of phosphatidylcholine (hereinafter, PC) depending on the degree of purification are commercially available. In the present invention, the PC content is 20 to 99%, more preferably 40 to 90%, most preferably. Is preferably 50 to 80%.

  Examples of the component (C) polyhydric alcohol used in the present invention include ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, and 2,3-butylene. Glycol, tetramethylene glycol, hexylene glycol, octylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, etc. A trihydric alcohol such as glycerin, trimethylolpropane, 1,2,6-hexanetriol; a sugar alcohol such as sorbitol, xylitol, erythritol, maltitol, mannitol; ethyl glycerin, butylglycerin, hexylglycerin , Et Glyceryl ethers such as hexylglycerin; polyhydric alcohol polymers such as diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, polyglycerin, etc. Etc. These may be used singly or in combination of two or more. Among these, glycerin, propylene glycol, 1,3-propanediol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1 1,2-octanediol is preferred, and 1,2-pentanediol, 1,3-butylene glycol, and glycerin are most preferred.

  The cosmetic composition of the present invention comprises the aforementioned components (A) to (C), the weight ratio of the component (A) to the component (B) is 9: 1 to 6: 4, and the component (A) And the total content of the component (B) is 2 to 30% by weight, and the content of the component (C) is 70 to 98% by weight. There is no restriction | limiting in particular in the manufacturing method of the composition for cosmetics of this invention, For example, it can manufacture by stirring and mixing component (A)-(C) at about 60 degreeC.

  The cosmetic composition thus obtained can form vesicles containing MEL simply by dispersing in water. At this time, an apparatus having a high stirring force such as a homomixer is not necessary, and the production with a stirring force such as a propeller or a stirrer is possible. The particle size of the vesicle obtained using the cosmetic composition of the present invention is 100 nm or less, and the appearance of the resulting cosmetic is transparent and has excellent temporal stability. If the weight ratio of component (A) to component (B) is outside the range of 9: 1 to 6: 4, vesicles having a sufficiently small particle size cannot be formed, and the appearance and stability over time are not sufficient. In addition, if the total content of the component (A) and the component (B) is less than 2% by weight, the effect of the present invention cannot be sufficiently exerted. ) Does not sufficiently dissolve in the component (C), and the effects of the present invention cannot be exhibited.

  The blending amount of the cosmetic composition of the present invention in the cosmetic is not particularly limited, but is usually 0.01 to 30% by weight, preferably 0. 0% from the viewpoint of the appearance and stability with time of the resulting cosmetic. It is 05 to 15% by weight, more preferably 0.1 to 10% by weight.

  The cosmetic of the present invention has an average degree of polymerization calculated from a linear or branched divalent carboxylic acid having 14 to 22 carbon atoms and a hydroxyl value from the viewpoint of further improving the appearance and temporal stability of the cosmetic. You may contain the oligomer ester with -15 polyglycerol. As such an oligomer ester, for example, (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 is commercially available from Nippon Seika Co., Ltd. under the trade names Neosole-Aqua and Neosole-AquaS. By containing such a component, even if an organic acid such as citric acid or a polysaccharide such as sodium hyaluronate or xanthan gum coexists, the cosmetic of the present invention can maintain the appearance and stability over time. Such an oligomer ester is usually used in an amount of about 0.01 to 10% by weight, preferably about 0.05 to 5% by weight.

  The cosmetic of the present invention may contain a polyhydric alcohol from the viewpoint of further improving the appearance and temporal stability of the cosmetic. Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, tetramethylene glycol, hexylene glycol, Divalent alcohols such as octylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol; glycerin, trimethylol Trivalent alcohols such as propane, 1,2,6-hexanetriol; sugar alcohols such as sorbitol, xylitol, erythritol, maltitol, mannitol; glycers such as ethyl glycerin, butyl glycerin, hexyl glycerin, ethyl hexyl glycerin Rirueteru diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerol, triglycerol, tetraglycerol, polyhydric alcohol polymers such as poly glycerin and the like. These may be used singly or in combination of two or more. Of these, polyhydric alcohols having 3 to 8 carbon atoms are preferable, and glycerin, propylene glycol, 1,3-propanediol, dipropylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol and the like are more preferable. By containing such a component, even if an organic acid such as citric acid or a polysaccharide such as sodium hyaluronate or xanthan gum coexists, the cosmetic of the present invention can maintain the appearance and stability over time. Such a polyhydric alcohol is usually used in an amount of about 0.1 to 70% by weight, preferably about 0.5 to 50% by weight.

  In the cosmetic of the present invention, in addition to the cosmetic composition of the present invention, water and additives added to the normal cosmetic as necessary, such as oil bases, surfactants, alcohols, humectants, Polymers, thickeners, gelling agents, antioxidants, preservatives, bactericides, chelating agents, pH adjusters / acids / alkalis, UV absorbers, whitening agents, solvents, exfoliating / dissolving agents, antipruritics, anti-inflammatory agents Agent, antiperspirant, refreshing agent, antihistamine, astringent, stimulant, hair-growth agent / blood circulation promoter, reducing agent / oxidant, polymer powder, hydroxy acid, vitamins and derivatives thereof, saccharides and derivatives thereof , Organic acids, enzymes, nucleic acids, hormones, inorganic powders, fragrances, pigments and the like can be added. These components may be embedded inside vesicles containing MEL.

  Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as cannic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Type hydrocarbons such as candelilla wax, carnauba wax, rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Tropsch wax, polyethylene wax, waxes such as ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cacao butter, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Fats and oils; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, Phospholipid derivatives such as partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytoster Sterols such as oleol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl) ), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N Acyl sarcosine alkyl esters such as lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phyto Sterol esters such as steryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / phytosterol complex, etc. Lipid complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl parmitate, octyldodecyl palmitate, cetyl octanoate, hexyl decyl octanoate, isotridecyl isononanoate, isononyl isononanoate, isononanoate Isotridecyl acid, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octeodecanoate Ludodecyl, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, ethyl avocado oil fatty acid, Isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, methyl heptyl laurate, methyl heptyl myristate, methyl heptyl palmitate, methyl heptyl isostearate, diethyl sebacate, diisopropyl sebacate, sebacic acid Dioctyl, diisopropyl adipate, dibutyl octyl sebacate, diisobutyl adipate, Monoalcohol carboxylates such as dioctyl succinate and triethyl citrate; oxyacid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, and γ-ercalactone; glyceryl trioctanoate, triolein Glyceryl acid, glyceryl triisostearate, glyceryl diisostearate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin Triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, dicapri Neopentyl glycol acid, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate (isostearin) Acid / sebacic acid) ditrimethylolpropane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca (erucic acid) / Isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, distearic acid Polyhydric alcohol fatty acid esters such as recall (ethylene glycol distearate), dineopentanoic acid 3-methyl-1,5-pentanediol, dineopentanoic acid 2,4-diethyl-1,5-pentanediol; alkyl such as dicaprylyl ether Ethers: Diisopropyl dimerlinoleate diisopropyl, dimer dilinoleate diisostearyl, dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate (phytosteryl / behenyl), dimer dilinoleate (phytosteryl / isostearyl / cetyl) / Stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearic dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydro Dimer acid or dimer diol derivative such as sialkyl dimer linoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid Fatty acid alkanols such as diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA) Amides: Dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsilane) Xanthine, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, aminopropyldimethicone and amodimethicone Polyether-modified silicone such as amino-modified silicone, cation-modified silicone, dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl Ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation Modified and polyether-modified silicones, amino- and polyether-modified silicones, alkyl- and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, silicones such as polysiloxane / oxyalkylene copolymers Fluorinated oils such as perfluorodecane, perfluorooctane and perfluoropolyether are preferred.

  As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosane diacid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan Sulfuric acid; white jellyfish extract; white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium Salt: betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, aspa Amino acids such as gin, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and the salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagenolytic peptide, hydrolyzed collagen, Hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat protein Degraded peptides, hydrolyzed wheat protein, casein-degraded peptides, acylated peptides and other protein peptides and their derivatives; palmitoyl oligopeptides , Acylated peptides such as palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, glutathione, albumin, milk Chin; choline chloride, phosphorylcholine; placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract, merirot extract Preferred are ceramides such as animal and plant extract components such as natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide, and sugar-ceramide-containing extracts. All It is.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acylamino acid salts such as sodium phosphate, triethanolamine cocoylglutamate, sodium lauroylglutamate, sodium myristoylglutamate, sodium stearoylglutamate, ditriethanolamine palmitoylaspartate, cocoylalaninetriethanolamine, lysine Nadilauroylglutamate; sodium laureth acetate, etc. Polyoxyethylene alkyl ether acetates; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; Fatty acid glyceride sulfate such as coconut oil fatty acid sodium glycerin sulfate; Oxyethylene sulfate; Olefin sulfonate such as sodium α-olefin sulfonate; Alkyl sulfosuccinate such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; Disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate Alkyl ether sulfosuccinates such as sodium acid, sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonate; alkanesulfonate; α-sulfo fatty acid methyl ester salt; acyl isethionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetates; alkyl ether phosphates such as sodium laureth phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate esters such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphorus Fatty acid amide ether phosphates; Phospholipids such as phosphatidylglycerol, phosphatidylinositol and phosphatidic acid; Silicone anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone and sulfuric acid-modified silicone; Among the ionic surfactants, laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether) ), Behenes (polyoxyethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether), octyldecesses (polyoxyethylene octyldodecyl ether), and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers Polyoxyethylene alkyl phenyl ether; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil Castor oil and hydrogenated castor oil derivatives such as monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polio Polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / poly Oxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; PPG-9 di (Poly) glycerin polyoxypropylene glycol such as glyceryl; glyceryl stearate, glyceryl isostearate, Glyceryl mycinate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-oleate pyroglutamate, glyceryl monostearate malate, etc. Glycerin fatty acid partial esters: polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl-6 distearate, 10, polyglyceryl tristearate, polyglyceryl decastearate -10, polyglyceryl isostearate 2, 3, 4, 5, 6, 8, 10, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 10, polyglyceryl triisostearate 2, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 8, dioleate polyglyceryl-6, trioleate polyglyceryl -2, polyglyceryl fatty acid ester such as polyglyceryl-10 dekaoleate; ethylene glycol mono fatty acid ester such as ethylene glycol monostearate; propylene glycol mono fatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid Maltitol partial fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbita Sorbitan fatty acid esters such as monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside Sugar ester partial esters such as fatty acid esters and undecylenic acid trehalose; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohols; reduced lanolins; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene mono Polyoxyethylene fatty acid mono- and diesters such as oleate and polyoxyethylene dioleate; polyoxyethylene propylene glycol Polyoxyethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol fatty acid esters such as polyoxyethylene monooleate such as polyoxyethylene glycerol triisostearate; polyoxyethylene Polyoxyethylene sorbitan fatty acid esters such as sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate Polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate, etc. Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable fats and oils such as polyoxyethylene sorbitol beeswax; Isostearyl glyceryl ether, chimyl alcohol, seraalkyl alcohol, batyl Alkyl glyceryl ethers such as alcohols; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acids Amides; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), la Phosphoric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamic acid MEA), palmitic acid diethanolamide (partamic acid DEA), coconut oil Fatty acid alkanolamides such as fatty acid methylethanolamide (cocamidomethyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkylmercaptan; Polyether-modified silicone such as dimethicone copolyol, polysiloxane-oxyalkylene copolymer, polyglycerin-modified silicone Silicone-based nonionic surfactants such as corn and sugar-modified silicone; and cationic surfactants such as alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; Alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines such as stearamidepropyldimethylamine and stearamideethyldiethylamine and salts thereof; stearoxypropyldimethyl Alkyl ether amines such as amines and salts or quaternary salts thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyl dimethyl Fatty acid amide type quaternary ammonium salts such as ruammonium and ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and salts or quaternary salts thereof; alkylamine salts; fatty acid amidoguanidinium salts; Alkyltrialkylene glycol ammonium salt; Benzalkonium salt; Benzethonium salt; Pyridinium salt such as cetylpyridinium chloride; Imidazolinium salt; Alkylisoquinolinium salt; Dialkyl morpholinium salt; Polyamine fatty acid derivative; Aminopropyl dimethicone And amino-modified silicone such as amodimethicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone Cationic surfactants, etc .; in amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryl dimethylaminoacetic acid betaine); cocamidopropyl betaine, lauramidopropyl betaine, etc. Fatty acid amide alkyl-N, N-dimethylamino acid betaines; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; alkyldimethylamino Phosphate betaines such as ethanol phosphates; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, water Phospholipids such as raw-added soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants; Preferable examples include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymers, and various silicone surfactants.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazoline derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzoyl chloride Luconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol , Photosensitizers, antibacterial zeolite, and silver ion are preferable, but when used as an antibacterial agent or antiseptic agent for antiseptic purposes, phenoxyethanol; 1 from the viewpoint of safety of cosmetics or skin external preparations; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.

  Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

  Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid-based UV absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone purple 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphsulfone Preference is given to acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

  Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

  As plant / animal / microbe extracts, Iris extract, Ashitaba extract, Asunaro extract, Asparagus extract, Avocado extract, Achacha extract, Almond extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Ginkgo biloba extract, Ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.

  As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Base dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4- Nitro dyes such as hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2 and Basic Blue 26; disperse dyes; inorganic white such as titanium dioxide and zinc oxide Pigments: Inorganic red pigments such as iron oxide (Bengara) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and loess; Black iron oxide, low-order titanium oxide, etc. Inorganic pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica; Titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil; aluminum powder, copper powder, gold, etc. Surface treated inorganic and metal powder pigments: Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204 No., Yellow 205, Yellow 401, Blue 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Organic pigments such as zirconium, barium or aluminum lake such as yellow 5, yellow 202, yellow 203, green 3 and blue 1; surface treatment organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene , Catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochini Natural pigments and dyes such as naphthoquinones such as ru and shikonin, bixin, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m- Oxidative dye intermediates and couplers such as p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; Oxidizing dyes; dihydroxyacetone is preferred.

  Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  Examples of the cosmetics containing the cosmetic composition of the present invention include hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, skin external preparations such as ointments, and the like. . From the viewpoint of exerting the effects of the present invention, it can be preferably used particularly for hair cosmetics and basic cosmetics. The cosmetic of the present invention can be produced according to a usual method.

  The types of cosmetics containing the cosmetic composition of the present invention will be described in more detail. Examples of hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, and rinse integrated types. Shampoo such as shampoo; rinse, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow , Split coat, hair oil, permanent wave agent, straight permanent agent, oxidative hair dye, hair bleach, hair color pre-treatment, hair color after treatment, permanent pre-treatment, Over Ma after treatments, hair manicure, and as hair growth agents are preferred.

  Basic cosmetics include soft lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, Nourishing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; Liposome cosmetics such as liposomal serum and liposome lotion; packs and masks such as peel-off pack, powder pack, washing pack, oil pack, cleansing mask; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing gel Facial cleansers such as oils, cleansing masks, powders and facial cleansers; cosmetic soaps, transparent soaps, medicated soaps, liquid soaps, shaving soaps, synthetic cosmetic soaps Soap can be mentioned as preferred.

  As makeup cosmetics, white powder, dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment are preferable. .

  Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.

  Body cosmetics include body shampoos and other body cleansers, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics, depigmenting agents, depilation / hair removal agents, bathing agents, insect repellents, etc. A repeller is preferred.

  Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

  Examples of the dosage form of the cosmetic or the external preparation for skin containing the cosmetic composition of the present invention include oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type emulsified cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, kneaded cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, Preferred examples include gel cosmetics, paste cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

  The following examples further illustrate the present invention in detail but are not to be construed to limit the scope thereof.

(Production of cosmetic composition)
The composition for cosmetics of this invention was produced with the composition of Table 1 (Examples 1-5). Moreover, the composition outside the range of the composition for cosmetics of this invention with the composition of Table 2 was produced (Comparative Examples 1-6).

(Stability of cosmetic composition over time)
The cosmetic composition obtained above was stored at 25 ° C. for 1 week, and changes in appearance were confirmed. Evaluation was performed in the following three stages, and the results are shown in Tables 1 and 2. From the results of Tables 1 and 2, the cosmetic composition of the present invention was excellent in stability over time. On the other hand, those using a lecithin with a low PC content (Comparative Example 5) and those with a content of (A) and (B) exceeding 30% (Comparative Example 6) are not sufficiently dissolved in the component (C). As a result, the stability over time was insufficient.

〇 No change in appearance and initial △ Appearance changed slightly from initial × Appearance changed significantly from initial

(Preparation of vesicle-containing lotion 1)
While stirring 1 g of purified water at 300 rpm with a stirrer at 300 rpm, 1 g of each of the cosmetic compositions of Examples 1 to 5 and Comparative Examples 1 to 6 was slowly added to purified water and stirred at room temperature for 5 minutes. The formed lotion was prepared. The obtained lotion was evaluated for appearance, stability with time, and particle size by the following methods. The results are shown in Table 3.

<Appearance>
About the obtained vesicle containing lotion, the external appearance was evaluated in the following three steps.

〇 Transparent to slightly turbid △ Some turbid × Very turbid

<Stability over time>
The obtained vesicle-containing lotion was stored at room temperature for one month, and the appearance was evaluated in the following three stages.

〇 No change in initial and appearance △ Appearance has changed slightly from the beginning × Appearance has changed significantly from the beginning

<Particle size>
The particle diameter was confirmed by electron microscope observation (TEM image), and the particle diameter was evaluated in the following two stages.

〇 Observed particle size is smaller than 100 nm × Observed particle size is larger than 100 nm

As an example, a TEM image of the vesicle obtained with the cosmetic composition of Example 2 is shown in FIG. As can be seen from FIG. 1, it was confirmed that the particle size was smaller than 100 nm and a vesicle structure was formed.

  From the results in Table 3, a cosmetic composition having a weight ratio of components (A) :( B) of 9: 1 to 6: 4 and a content of (A) and (B) of 30% or less is used. The lotions (Examples 1 to 5) obtained in this manner were all good in appearance, stability and particle size. On the other hand, these evaluations were not sufficient for the lotions (comparative examples 1 to 3 and 6) using the cosmetic composition outside the range. Also, those using lecithin with a PC content of 97.2% and 25.2% (Comparative Examples 4 and 5) did not give good results.

(Preparation of vesicle-containing lotion 2)
5 g of each polyhydric alcohol listed in Table 4 and 1 g of the cosmetic composition of Example 2 were mixed and heated to 60 ° C. (Part A). In a separate container, 94 g of purified water heated to about 60 ° C. is added. While stirring with a stirrer at 300 rpm, part A is slowly added, stirred for 5 minutes, and allowed to cool to room temperature. Was made. The obtained lotion was evaluated for permeability over time at a wavelength of 600 nm and evaluated by the following method. The results are shown in Table 4.

<Stability over time>
The obtained vesicle-containing lotion was stored at 50 ° C. for 2 weeks, and the appearance was evaluated according to the following three stages.

〇 No change in initial and appearance △ Appearance has changed slightly from the beginning × Appearance has changed significantly from the beginning

(Preparation of vesicle-containing lotion 3)
5 g of each polyhydric alcohol listed in Table 5 and 1 g of the cosmetic composition of Example 2 were mixed and heated to 60 ° C. (Part A). In a separate container, add 94 g of purified water heated to about 60 ° C. and 2.5 g of xanthan gum 2% aqueous solution, slowly add part A while stirring with a stirrer 300 rpm, stir for 5 minutes, allow to cool to room temperature, A lotion in which a contained vesicle was formed was prepared. About the obtained lotion, the transmittance | permeability in wavelength 600nm was measured, and the result was shown in Table 5.

  From the results of Tables 4 and 5, it was found that the lotion containing the cosmetic composition of the present invention has high permeability and excellent transparency. Further, in addition to the cosmetic composition of the present invention, a lotion containing a polyhydric alcohol has higher permeability than a non-polyhydric alcohol compounded product, and transparency and stability over time may be improved. I understood.

Example 20 Whitening lotion A lotion having the following formulation was prepared. This lotion is excellent in transparency, excellent in whitening effect, keeps the skin healthy, and can prevent wrinkles due to rough skin and dryness.

Component Blending amount (% by weight)
---------------------------------------
Part A Cosmetic composition of Example 2 2.0
BG 4.0
Inositol 0.5
Part B Xanthan gum 0.05
BG 3.0
Purified water 20.0
Part C 3-O-ethylascorbic acid (VC ethyl: Nippon Seika) 1.0
Purified water 5.0
Part D white jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.01
Glycyrrhizic acid 2K 0.05
Ethanol 3.0
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid 0.1
Amount of Na citrate pH to 4.5 Purified water Amount to total of 100 -------------------------------- --------
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A was heated to 50 ° C. and slowly added to Part B with stirring to prepare a nanovesicle solution. Furthermore, C part and D part mixed beforehand were added, and it was set as the uniform liquid.

Example 21 Whitening lotion A lotion having the following formulation was prepared. This skin lotion has an excellent whitening effect and can prevent fine wrinkles due to rough skin and dryness.

Component Blending amount (% by weight)
---------------------------------------
Part A Cosmetic composition of Example 1 3.0
DPG 3.0
Glycerin 1.0
Part B purified water 20.0
Part C Tranexamic acid (Nippon Seika) 2.0
Purified water 20.0
Part D Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosol-Aquilio: Nippon Seika) 0.5
Niacinamide 0.3
Betaine 1.0
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A was mixed and slowly added to Part B while stirring to prepare a nanovesicle solution. Furthermore, C part and D part mixed beforehand were added, and it was set as the uniform liquid.

Example 22 Moisturizing lotion A lotion having the following formulation was prepared. This lotion was a highly transparent preparation. It also moisturizes the skin, keeps it fresh by suppressing moisture transpiration, and prevents fine wrinkles due to rough skin and dryness.

Component Blending amount (% by weight)
--------------------------------------
Part A Cosmetic composition of Example 5 1.0
Diglycerin 3.0
Hydrolyzed hyaluronic acid 0.01
Arginine 0.05
Part B purified water 20.0
Part C (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10
(Neosol-AquaS: Nippon Seika) 1.0
Betaine 0.5
Pullulan 0.5
Hyaluronic acid Na 0.01
Hydroxyethyl cellulose 0.03
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and slowly added to Part B while stirring to prepare a nanovesicle solution. Furthermore, it added to the C part mixed previously, and was set as the uniform liquid.

Example 23 Moisturizing lotion A lotion having the following formulation was prepared. This lotion has an excellent moisturizing effect, moisturizes the skin, keeps it fresh, and prevents wrinkles caused by dry skin and dry skin. Moreover, it was possible to disperse | distribute an oil-based component (astaxanthin, ubiquinone) uniformly, without adding surfactant.

Component Blending amount (% by weight)
---------------------------------------
Part A Cosmetic composition of Example 3 2.0
Diglycerin 3.0
Astaxanthin 0.01
Ubiquinone 0.05
Part B purified water 20.0
Part C (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10
(Neosol-AquaS: Nippon Seika) 1.0
PEG / PPG / polybutylene glycol-8 / 5/3 glycerol 0.5
Glucosylceramide 0.5
Glucosyl rutin 0.01
Polyquaternium-51 0.5
Acetyl hexapeptide-8 0.001
Hydrolyzed collagen 0.05
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A was mixed and part B was slowly added with stirring to prepare a nanovesicle solution. Furthermore, it added to the C part mixed previously, and was set as the uniform liquid.

Example 24 Gel lotion A lotion having the following formulation was prepared. This skin lotion has a sense of penetrating the skin, keeps it moist and fresh, and prevents wrinkles due to skin dryness and dryness.

Component Blending amount (% by weight)
-----------------------------------
Part A Hydrogenated lecithin, phytosterols (Phytocompo-PP: Nippon Seika) 1.0
Glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl behenate 0.8
Stearic acid 0.3
PEG-10 Dimethicone 0.4
Part B Composition for Cosmetics of Example 1 3.0
Purified water 20.0
Part C Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexyl glycerin 0.2
Poly HEMA glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Hyaluronic acid Na 0.01
Carbomer 0.06
Hydroxide K 0.05
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dispersed uniformly. Part C was mixed, stirred well, homogenized, and heated to about 70 ° C. Part B was stirred with a propeller to prepare a nano vesicle solution. C part was added to A part, it stirred using the homomixer at about 70 degreeC, it cooled to about 40 degreeC, and the liquid mixture of B part was added.

Example 25 Transparent Gel A gel having the following formulation was prepared. There was a feeling of penetration into this gel skin. It also keeps the skin moist and fresh and prevents wrinkles caused by rough skin and dryness.

Component Blending amount (% by weight)
--------------------------------------
Part A Cosmetic composition of Example 2 0.5
Glycerin 3.0
Purified water 30.0
Part B PEG-4000 0.2
Methyl Gluces-10 1.0
Phenoxyethanol 0.3
Pyridoxine hydrochloride 0.05
Ethylhexyl glycerin 0.2
Hydroxyethyl cellulose 0.05
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.01
Hydrolyzed collagen 0.01
Amount C of purified water totaling 100
(Ammonium dimethyltaurate acrylate / vinylpyrrolidone) copolymer 0.05
(Acrylates / alkyl acrylate (C10-30)) cross polymer 0.15
Arginine 0.25
Purified water 30.0
---------------------------------------
(Preparation method)
Part A was stirred with a propeller to prepare a nano vesicle solution. Part C was a viscous liquid when mixed. Part B was mixed to obtain a uniform liquid. Part A and part B were added to part C to make it uniform.

Example 26 Whitening Emulsion An emulsion having the following formulation was prepared. This emulsion is excellent in whitening effect and barrier function improving effect, has a penetrating feeling on the skin, moisturizes and maintains freshness, and prevents wrinkles due to skin dryness and dryness.

Component Blending amount (% by weight)
---------------------------------------
Part A dimer linoleic acid di (isostearyl / phytosteryl)
(LUSPLAN PI-DA: Nippon Seika) 1.0
Bisdiglyceryl polyacyl adipate-2
(Plandool-DP: Nippon Seika) 1.0
Cetyl ethylhexanoate (NS-CIO: Nippon Seika) 10.0
Hydrogenated lecithin, phytosterols, BG, glycerin (Phytocompo-SP: Nippon Seika) 10.0
Phenyltrimethicone 3.0
Myristyl alcohol 2.0
Cetanol 1.0
Part B stearoxyhydroxypropylmethylcellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Cosmetic composition of Example 2 1.0
Pentylene glycol 2.0
Glycerin 3.0
Purified water 20.0
Part D VC ethyl (Nippon Seika) 1.0
Penteto acid 5Na 0.1
Citric acid 0.1
Amount of Na citrate pH 4.5 Purified water 5.0
Part E Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part E were each heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was mixed to prepare a vesicle solution. At about 70 ° C., part A was added and emulsified while stirring part E with a homodisper. At about 50 ° C., parts B, C and D were added and stirred to dissolve uniformly.

Example 27 Moisturizing emulsion An emulsion having the following formulation was prepared. The emulsion contains two types of particles consisting of parts A, B, and E and part C, giving it a unique feeling of use, moisturizing the skin and keeping it fresh, dry and dry Can prevent small wrinkles.

Component Blending amount (% by weight)
----------------------------------
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Phytocompo-PP (Nippon Seika) 1.0
Hydrogenated lysolecithin (LP70H: Nippon Seika) 0.1
Part B Triethylhexanoin (IOTG: Nippon Seika) 3.0
Dimer dilinoleic acid dimer dilinoleyl,
Tri (caprylic acid / capric acid) glyceryl (LUSPLAN SR-DM4: Nippon Seika) 0.5
Dimethicone (100CS) 5.0
Hydrogenated polyisobutene 3.5
Cetostearyl alcohol 1.0
Aralkyl alcohol 0.1
Jojoba alcohol 3.0
Kimyl alcohol 0.3
Serakil alcohol 0.1
Hexyldecanol 0.5
Part C Cosmetic composition of Example 1 2.0
Purified water 20.0
Part D (hydroxyethyl acrylate / acryloyl dimethyltaurine Na) copolymer 0.2
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.03
Carbomer 0.1
Purified water 30.0
Part E (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10, glycerin (Neosol-AquaS: Nippon Seika) 0.5
Polyquaternium-51 1.0
Ascorbyl glucoside 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 -----------------------------------
(Preparation method)
Part A, part B and part E were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part C was mixed with a propeller (room temperature) to prepare a nano vesicle solution. Part D was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part E was added and emulsified. At about 50 ° C., C and D parts were added, and the mixture was stirred and cooled to about 40 ° C.

Example 28 UV emulsion A UV emulsion having the following formulation was prepared. This milky lotion was excellent in sunburn prevention effect, and had a light feeling without stickiness or tingling.

Component Blending amount (% by weight)
--------------------------------------
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 5, ceramide 6
(Phytocompo-C5: Nippon Seika) 1.0
Cosmetic composition of Example 5 1.5
Part B Dineopentanoic acid diethylpentanediol (Neosol-DE: Nippon Seika) 5.0
Dineopentanoic acid methylpentanediol (Neosolu-MP: Nippon Seika) 2.0
Isodecyl neopentanoate (DUB VCI-10: Nippon Seika) 2.0
Plandool-ISS (Nippon Seika) 0.8
Dimethicone 5.0
Ethyl hexyl methoxycinnamate 5.0
Dimethoxybenzylidene dioxoimidazolidine propionate ethylhexyl 0.5
t-Butylmethoxydibenzoylmethane 0.5
Synoxate 1.0
Dihydroxydimethoxybenzophenone 0.5
Tetrahydroxybenzophenone 0.1
Methyl bis (trimethylsiloxy) trimethoxycinnamate
Silylisopentyl 0.5
2-Ethylhexyl paradimethylaminobenzoate 1.0
Bisethylhexyloxyphenol methoxyphenyl triazine 1.0
Diethylaminohydroxybenzoyl hexyl benzoate 1.0
Ethylhexyl triazone 1.0
3- (4′-Methylbenzylidene) -d, l-camphor 1.0
Methyl 2,5-diisopropylcinnamate1.0
Octyl salicylate 2.0
Homomentil salicylate 1.5
1- (3,4-Dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione 1.0
Amyl paradimethylaminobenzoate 0.5
Polyglyceryl pentastearate-10 1.0
N-lauroyl sarcosine isopropyl 2.0
Isostearyl alcohol 1.0
Stearyl alcohol 0.5
2-Octyldodecanol 1.0
Dimer diol 0.5
Benzyl alcohol 0.5
Isostearic acid 1.0
Behenic acid 0.5
Undecylenic acid 0.2
12-hydroxystearic acid 0.2
Palmitooleic acid 0.1
Oleic acid 0.7
Linoleic acid 0.2
Linolenic acid 0.01
Erucic acid 1.0
Rice wax 0.1
Ceresin 0.1
Paraffin wax 0.1
Microcrystalline wax 0.1
Polyethylene 0.1
Safflower oil 0.5
Olive oil 0.5
Castor oil 0.3
Avocado oil 0.3
Sesame oil 0.3
Tea oil 0.3
Evening primrose oil 0.3
Wheat germ oil 0.3
Part C Hydroxyethylcellulose 0.2
Stearoxyhydroxypropylmethylcellulose 0.8
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.03
Purified water 20.0
Part D Neosolue-AquaS (Nippon Seika) 0.5
3-O-ethylascorbic acid (Nippon Seika; VC ethyl) 0.5
Arbutin (Nippon Seika) 0.5
Phenoxyethanol 0.2
Methylparaben 0.15
Sodium dihydroxydimethoxybenzophenone disulfonate 0.5
Phenylbenzimidazolazosulfonic acid 1.0
Hydroxide Na 1.0
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A, part B and part D were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homomixer, part D was added and emulsified. C. Part C was added at about 50.degree. C., and the mixture was stirred and cooled to about 40.degree.

Example 29 UV emulsion A UV emulsion having the following formulation was prepared. This emulsion contains two types of particles consisting of A, B, and E parts and D part, giving it a distinctive feeling of use and being excellent in sun protection, without stickiness and creaking. It was moist.
Component Blending amount (% by weight)
---------------------------------------
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Phytocompo-PP (Nippon Seika) 1.0
Part B Plandool-SUN (Nippon Seika) 1.0
Dimethicone 10.0
Ethyl hexyl methoxycinnamate 7.0
t-Butylmethoxydibenzoylmethane 1.5
Bisethylhexyloxyphenol methoxyphenyl triazine 1.0
Diethylaminohydroxybenzoyl hexyl benzoate 0.5
Ethylhexyl triazone 1.0
Homosalate 0.5
4- (2-β-Glucopyranosiloxane) propoxy-2-hydroxybenzophenone 0.7
2-Hydroxy-4-methoxybenzophenone 0.3
Dimethyldiethylbenzalmalonate 0.5
Part C Hydroxyethylcellulose 0.2
Stearoxyhydroxypropylmethylcellulose 0.8
White jellyfish polysaccharide (Tremoist-TP: Nippon Seika) 0.03
Purified water 20.0
Part D Cosmetic composition of Example 3 1.0
Purified water 15.0
Part E Neosolue-AquaS (Nippon Seika) 0.5
VC ethyl (Nippon Seika) 1.0
Tranexamic acid 1.0
Glyceryl ascorbic acid 0.5
Arbutin 0.5
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Amount F totaling 100 Titanium oxide (silica treatment) 1.0
Zinc oxide (silica treatment) 2.0
----------------------------------------
(Preparation method)
Part A, part B and part E were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part C was mixed and stirred to give a viscous liquid. Part D was mixed by propeller stirring to obtain a nano vesicle solution. After adding part B while stirring part A with a homodisper, part E was added and emulsified. After cooling, at about 50 ° C., D part and F part were added and stirred to cool to about 40 ° C.

Example 30 Skin Care Cream A cream having the following formulation was prepared. This cream moisturizes the skin, keeps it fresh, and prevents wrinkles caused by rough skin and dryness.

Component Blending amount (% by weight)
--------------------------------------
Part A Plandool-ISS (Nippon Seika) 1.0
Jojoba oil 2.0
Plandool-H (Nippon Seika) 1.0
Neosolute-MCT (Nippon Seika) 5.0
LUSPLAN DD-DHR (Nippon Seika) 3.0
Propylene glycol monostearate 0.6
Behenyl alcohol 2.0
Ethylparaben 0.1
Liquid isoparaffin 0.5
Carnauba wax 0.3
Corn oil 0.3
Rapeseed oil 1.0
Sunflower oil 1.0
Wheat germ oil 1.0
Linseed oil 0.1
Cottonseed oil 0.1
Soybean oil 0.1
Cholesteryl nonanoate 0.1
Cholesteryl stearate 0.1
Cholesteryl isostearate 1.0
Cholesteryl oleate 0.1
Cholesteryl 12-hydroxystearate 0.1
Long-chain branched fatty acid cholesteryl 0.3
Octyldodecyl myristate 1.0
Daimerlinoleic acid hydrogenated castor oil 1.0
Hydroxyalkyl dimer linoleyl ether 1.0
Phenyltrimethicone 1.0
Diphenyl dimethicone 1.0
Methyl hydrogen polysiloxane 1.0
Polyglyceryl-3 polydimethylsiloxyethyl dimethicone 0.5
Polyoxyethylene methylpolysiloxane copolymer 1.0
Tannin 0.01
Sesamin 0.01
Protoanthocyanidin 0.01
Grab lysine 0.01
Grablen 0.01
Liquiritin 0.01
Isoliquitin 0.01
Lactoferrin 0.01
Gingerall 0.01
Gingerol 0.01
Part B (acryloyldimethyltaurine /
Methenic acid behenes-25) copolymer 0.2
(Acryloyldimethyltaurate ammonium / VP) copolymer Purified water 20.0
Part C Cosmetic composition of Example 4 0.5
Hydrogenated lecithin, cholesterol (Composite-PC: Nippon Seika) 1.5
Lysolecithin 0.05
Hydrogenated egg yolk lecithin 0.1
Stigmasterol 1.0
Stigmasterol 1.0
Dihydrocholesterol 0.1
Lanosterol 0.1
Dihydrolanosterol 0.1
Glycerin 7.0
DPG 7.0
Menthol 0.1
Camphor 0.1
Tocopherol ferulate 0.1
Tocopherol phosphate 0.1
Polyglyceryl laurate-10 0.5
Tocotrienol 0.1
Part D Citric acid 0.07
Sodium citrate appropriate amount EDTA-2Na 0.1
Tranexamic acid 2.0
Methylparaben 0.1
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed, heated to about 70 ° C., and dispersed uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. A part A was added to part C while stirring with a homogenizer, and then part D was added to emulsify. At about 50 ° C., part B was added and stirred to dissolve uniformly.

Example 31 Skin Care Cream A cream having the following formulation was prepared. This cream improves the feeling of use with two kinds of particles consisting of A and C parts and D part, and softens the skin. After use, the skin is moist and moist, and these effects last for a long time. .

Component Blending amount (% by weight)
------------------------------------
Part A Plandool-SUN (Nippon Seika) 1.0
Neosolu-Aculio (Nippon Seika) 1.5
Neosolute-EHS (Nippon Seika) 8.0
Plandool-ISS (Nippon Seika) 1.0
Diisopropyl sebacate (IPSE: Nippon Seika) 2.0
Batyl isostearate 2.0
Shea fat 3.0
Cyclopentasiloxane 5.0
Isostearyl pivalate 0.1
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Seika) 0.1
Ethylparaben 0.2
Stearyl alcohol 3.5
Dimethicone 1.0
Cyclomethicone 3.0
Tocopherol 0.1
Ascorbyl tetrahexyldecanoate 3.0
Tocopheryl ascorbyl phosphate 2.0
Placenta extract 1.0
Oryzanol 0.3
Phytosphingosine 0.0001
Ubiquinone 0.03
Carotene 0.05
Lycopene 0.01
Astaxanthin 0.01
Lutein 0.01
Peanut oil 0.1
Rice bran oil 1.0
Hydrogenated castor oil 0.3
Jojoba oil 2.0
Orange Raffy Oil 1.0
Liquid lanolin (liquid lanolin: Nippon Seika) 1.0
Lanolin (Purified Lanolin: Nippon Seika) 1.0
Polyoxyethylene lanolin 1.0
Lanolin Alcohol A (Nippon Seika) 0.3
Lanolin acetate 0.1
Cholesteryl acetate 0.1
Polyglyceryl triisostearate-2 1.0
PEG-60 glyceryl isostearate 1.5
Stearic acid PG (SE) 1.0
Glyceryl stearate (SE) 1.0
Octocrylene 0.05
Part B Tremoist-TP (Nippon Seika) 0.05
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
2-Methacryloyloxyethyl phosphorylcholine
Butyl methacrylate copolymer solution 0.05
(HEMA glucoside / ethyltrimonium methacrylate methacrylate) copolymer (20%, Nippon Seika) 0.4
Glutathione 0.3
4- (4-Hydroxyphenyl) -2-butanol 1.5
Butyl resorcinol 1.5
Arbutin (Nippon Seika) 3.0
Ascorbyl phosphate Mg 1.0
Part C BG 5.0
Glycerin 7.0
DPG 2.0
Pyrosulfite Na 0.1
Imidazolinium urea 0.1
Polyvinylpyrrolidone 0.1
Pullulan 0.1
Polyvinyl alcohol 0.1
Dehydroacetic acid 0.1
PEG-30 1.0
Diglycerin 1.0
Polyglycerin 1.0
Penteto acid 5Na 0.05
Phosphoric acid, phosphoric acid Na Appropriate amount Purified water Amount to be 100 in total D part Cosmetic composition of Example 2 1.0
Purified water 15.0
------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part C was heated to about 70 ° C. and dispersed. Part D was thoroughly stirred with a propeller to prepare a nanovesicle solution. While stirring with a homomixer at about 70 ° C., part A was gradually added to part C and mixed uniformly after emulsification, cooled to about 40 ° C., and parts B and D were added and mixed uniformly.

Example 32 Skin Care Cream A cream having the following formulation was prepared. This cream had a distinctive feeling of use due to the coexistence of particles consisting of parts A, B, and C and part D, and the skin was softened and moistened after use. These effects last for a long time.

Component Blending amount (% by weight)
-----------------------------------
Part A Glycerin 5.0
PG 2.0
Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6II
(Phytocompo-C: Nippon Seika) 1.0
Part B Lauroyl glutamate di (phytosteryl / octyldodecyl)
(Plandool-LG2: Nippon Seika) 0.5
Plandool-LG1 (Nippon Seika) 0.5
Dimer dilinoleic acid dimer dilinoleyl (LUSPLAN DD-DA7: Nippon Seika) 0.1
Plandool-MAS (Nippon Seika) 0.5
Glyceryl amidomethacrylate /
Stearyl methacrylate copolymer 0.05
Olive oil 3.5
Macadamia nut oil 4.5
Hydrogenated vegetable oil 3.0
Dimethicone (100cs) 0.5
Ethyl hexyl methoxycinnamate 2.0
Ethylparaben 0.15
Lanolin fatty acid octyldodecyl 1.0
Isostearic acid hydrogenated castor oil 0.5
Ethyl oleate 3.0
Avocado oil fatty acid ethyl 2.0
Isopropyl palmitate 2.0
Isopropyl isostearate 1.0
Methylheptyl laurate 3.0
Methyl heptyl myristate 3.0
Methylheptyl palmitate 3.0
Methylheptyl isostearate 3.0
Diethyl sebacate 1.0
Diisopropyl sebacate 1.0
Diisopropyl adipate1.0
Diisobutyl adipate 1.0
Dioctyl succinate 1.0
Triethyl citrate 1.0
Cetyl lactate 1.0
Diisostearyl malate 5.0
γ-docosalactone 0.2
Glyceryl trioleate 0.1
Glyceryl triisostearate0.1
Glyceryl diisostearate0.1
Tri (caprylic acid / capric acid / myristic acid /
Stearic acid) glyceryl 0.1
(Behenic acid / eicosanedioic acid) Glyceryl 0.1
Trimethylolpropane trioctanoate 0.5
Neopentyl glycol dicaprate 1.0
Perfluorodecane 1.0
Perfluorooctane 1.0
5,5′-Dipropyl-biphenyl-2,2′-diol 0.3
Oil-soluble chamomile extract 0.3
Oil-soluble licorice extract 0.05
Retinol 0.1
Retinol acetate 0.1
Retinol palmitate 0.1
Pyridoxine dioctanoate 0.1
Pyridoxine dipalmitate 0.1
Tocopherol nicotinate 0.1
Tocopherol acetate 0.1
Tocopherol linoleate 0.1
Glycyrrhetinic acid 0.05
Hinokitiol 0.05
Indomethacin 0.05
Hydrocortisone acetate 0.1
Prednisone 0.1
Diphedramine hydrochloride 0.1
Borneol 0.1
Cephalanthin 0.001
Photosensitive element 301 0.001
Photosensitive element 401 0.001
Cetyl tranexamate 2.0
Part C Cosmetic Composition of Example 2 2.5
Ascorbyl tetrahexyldecanoate 1.0
Purified water 10.0
Part D Methylparaben 0.1
Phenoxyethanol 0.2
Xanthan gum 0.1
(Acrylates / alkyl acrylate (C10-30)) Cross polymer 0.2
(Hydroxyethyl acrylate /
Acryloyldimethyltaurine Na) copolymer 0.2
Arginine 0.3
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dispersed uniformly. Part B was heated to about 80 ° C. and dissolved uniformly. Part C was stirred well to prepare a nano vesicle solution. While part A was stirred with a homodisper, part B was added and dispersed (part E). Further, D part was added to E part with stirring. Stir and cool to about 40 ° C.

Example 33 Scalp Lotion A scalp lotion having the following formulation was prepared. This lotion can soften the scalp and improve the stickiness and rustiness of the scalp.

Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 4.0
Pentylene glycol 2.0
Maltitol 0.5
Glycyrrhetinic acid 0.05
PPG-5 phytosterol 0.1
Cosmetic composition of Example 2 2.5
Part B Methylparaben 0.1
Purified water 50.0
Part C ethanol 10.0
Neosolu-Aquilio (Nippon Seika) 1.0
Tocopherol acetate 0.05
Menthol 0.1
Menthoxypropanediol 0.05
Betaine 0.2
Carrot extract 0.1
Assembly extract 0.1
Japanese cypress rafji root extract 0.003
Pyridoxine hydrochloride 0.05
Panthenol 0.1
PCA-Na 0.1
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Each component was measured and mixed uniformly. Part A was added to part B to prepare a nanovesicle solution. Further, C part was added with stirring to make uniform.

Example 34 Scalp Lotion A scalp lotion having the following formulation was prepared. This lotion has excellent moisturizing and penetrating feelings, improves the condition of the scalp, and can suppress stickiness and rustiness.

Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 2.0
Cosmetic composition of Example 5 0.3
Purified water 10.0
Part B Neosolute-AquaS (Japan Seika) 0.5
Nicotinamide 1.0
Dipotassium glycyrrhizinate 0.1
VC ethyl (Nippon Seika) 0.3
Hyaluronic acid Na 0.01
Tremoist-SL (Nippon Seika) 0.5
Caprylyl proline 0.3
Raffinose 0.2
Arginine 0.5
Serine 0.1
Glycine 0.1
Purified water 50.0
Part C ethanol 10.0
Methylparaben 0.1
Menthol 0.1
Menthoxypropanediol 0.1
Ethyl dicarboethoxy pantothenate 0.2
Camphor 0.1
Carrot extract 1.0
Assembly extract 1.0
Glycosyl trehalose 0.5
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was stirred with a propeller to prepare a nano vesicle solution. Each component of B part and C part was measured and mixed uniformly. After adding B part to A part and making it uniform, C part was added and made uniform.

Example 35 Body Shampoo A body shampoo having the following formulation was prepared. This body shampoo was foamy, moisturized and moistened, and provided a soft skin feeling.

Component Blending amount (% by weight)
--------------------------------
Part A Cosmetic composition of Example 2 0.3
Purified water 10.0
Part B Neosolute-AquaS (Japan Seika) 0.5
Cocoyl Methyl Taurine Na 10.0
Lauroyl hydrolyzed silk Na 6.0
Lauroylmethylalanine Na 10.0
Cocoamphoacetate Na (30%) 4.0
Cocamidopropyl betaine (30%) 10.0
Olefin (C14-16) sulfonic acid Na 5.0
Polyquaternium-10 1.3
Guar hydroxypropyltrimonium chloride 0.8
Acetyl hyaluronic acid Na 0.02
Cocamide DEA 3.0
Glycerin 5.0
Methylparaben 0.2
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part A was stirred and mixed with a propeller to prepare a nanovesicle solution. Part B was weighed and heated to about 80 ° C. and mixed uniformly. Part B was cooled with stirring and part A was added at 40 ° C.

Example 36 Shampoo A shampoo having the following formulation was prepared. This shampoo is foamy, moisturized and can be damaged.

Component Blending amount (% by weight)
--------------------------------
Part A Cosmetic composition of Example 1 0.5
Purified water 10.0
Part B Plandool-LG2 (Nippon Seika) 0.03
Neosolute-Aqlio (Nippon Seika) 0.1
Tremoist-SL (Nippon Seika) 0.5
Laureth-4 carboxylic acid Na (28%) 10.0
Laureth-6 carboxylic acid 4.0
Cocamidopropyl betaine (30%) 10.0
Lauroylmethylalanine Na (30%) 5.0
Cocamidomethyl MEA 3.0
Palm oil fatty acid PEG-7 glyceryl 5.0
Hydroxyl Na 1% solution 0.5
Polyquaternium-10 0.6
Cationized guar gum 0.2
Polyquaternium-7 0.5
EDTA-2Na 0.05
Methylparaben 0.2
Phenoxyethanol 0.4
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part A was stirred with a propeller to prepare a nano vesicle solution. Part B was weighed and heated at about 80 ° C. and stirred and mixed uniformly. Part B was cooled and part A was added at 40 ° C.

Example 37 Non-washing hair treatment A non-washing hair treatment of the following formulation was prepared. This hair treatment was able to improve the damage inside the hair and give a moist and smooth feeling without using silicone.

Component Blending amount (% by weight)
------------------------------------
Part A Cosmetic composition of Example 1 1.0
Purified water 10.0
Part B Polyquaternium-37 2.0
Squalane 2.0
PPG-3 caprylyl ether 2.0
Microcrystalline wax 0.1
Lanolin alcohol 0.2
Montan wax 0.1
Polyethylene wax 0.1
Beeswax 0.1
Owl 0.2
Ceresin 0.1
Dicapric acid PG 1.0
Almond oil 0.5
Ethylhexyl ethylhexanoate 1.0
Candelilla wax extract 0.1
Octyldodecyl erucate 4.5
Tocopherol acetate 0.02
γ-docosalactone, tri (caprylic acid / capric acid) glyceryl (Elcalactone MCT: Nippon Seika) 2.0
Dipentaerythrityl tripolyhydroxystearate1.5
Broccoli seed oil 0.3
Sphinganine 0.01
PPG-5 phytosteryl 0.5
Glycerin 4.0
Sorbitol 2.0
Phenoxyethanol 0.5
Part C Hydrolyzed conchiolin 0.1
Panthenol 0.1
Hydroxypropyltrimonium hyaluronate 0.01
Polyquaternium-11 0.2
Glycosyl trehalose 0.1
Glyceryl glucoside 0.3
Arginine 0.1
Purified water 10.0
Part D Purified water Total amount of 100 Hydroxypropyl starch phosphate 1.0
--------------------------------------
(Preparation method)
Part D was uniformly dispersed and heated to about 80 ° C. Next, part B was heated to about 80 ° C. and dissolved. Part A was stirred with a propeller to prepare a nano vesicle solution. Part B was added to part D with stirring and mixed uniformly, and then cooled to about 40 ° C. A and C parts were added and mixed uniformly.

Example 38 Scalp / hair treatment without washing off A scalp / hair treatment with the following formulation was prepared. This hair treatment improved the damage to the hair and improved the smoothness and moistness. In addition, the scalp environment can be improved.

Component Blending amount (% by weight)
------------------------------------
Part A Cosmetic composition of Example 3 0.5
Purified water 10.0
Part B Neosolute-AQulio (Nihon Seika) 2.0
Ethanol 40.0
Glycyrrhetinic acid 0.02
PPG-3 caprylyl ether 0.3
γ-docosalactone, diethyl sebacate (Erucalactone DES: Nippon Seika) 1.5
PEG / PPG-20 / 20 dimethicone 0.2
PEG-12 Dimethicone 0.4
Hydrogenated retinol 0.1
Tridohexyl decanoate pyridoxine 0.05
Bisglyceryl ascorbic acid 0.3
Hexyl 3-glyceryl ascorbic acid 0.3
Part C Triethanolamine 0.1
Purified water Total amount of 100 acrylates / alkyl acrylate (C10-30)) Crosspolymer 0.4
Carbomer 0.05
Tremoist-SL (Nippon Seika) 1.0
Acryloyldimethyltaurate ammonium / VP) copolymer 0.05
(Acryloyldimethyltauronium ammonium / methacrylic acid beheneth-25) cross polymer 0.1
Hydroxypropyl chitosan 0.1
Methylparaben 0.1
Phenoxyethanol 0.2
Part D VC ethyl (Nippon Seika) 0.05
Nicotinamide 0.3
Pyridoxine hydrochloride 0.1
Caffeine 0.1
Glucosyl trehalose 0.1
Purified water 10.0
------------------------------------
(Preparation method)
Parts B and D were heated to about 50 ° C. and dissolved. Part A was mixed with stirring with a propeller to prepare a nanovesicle solution. Next, part C was uniformly dispersed to obtain a viscous liquid. While stirring C part, it added in order of A, B, D part, and mixed uniformly.

Example 39 Hair Treatment A treatment having the following formulation was prepared. This treatment was a treatment capable of improving hair damage without giving silicone and giving a moist feeling, smoothness, a smooth feeling and a long-lasting feeling.

Component Blending amount (% by weight)
-----------------------------------
Part A Cosmetic composition of Example 4 2.0
Purified water 10.0
Part B Neosolu-Aculio (Nihon Seika) 0.2
Dimer dilinoleic acid dimer dilinoleyl, tri (caprylic acid / capric acid) glyceryl (LUSPLAN SR-DM4: Nippon Seika) 0.1
Candelilla wax 0.2
Cetyl Esters 0.3
Stearyl ethylhexanoate 1.0
Cetearyl alcohol 3.5
PEG-200 0.5
Hydroxyethyl cellulose 0.4
Cetrimonium chloride (30%) 1.0
Behentrimonium chloride (80%) 1.0
Trideceth-6 0.3
BHT 0.03
Part C Methylparaben 0.2
Citric acid 0.05
Purified water Amount D totaling 100 PPG-3 myristyl 0.5
DUB VIC-10 (Nippon Seika) 1.0
------------------------------------
(Preparation method)
Part B and part C were heated to about 80 ° C. and dissolved. Part A was mixed with stirring with a propeller to prepare a nanovesicle solution. C part was gradually added to B part and mixed uniformly. At about 50 ° C., part D was added with stirring to make it uniform.

Example 40 Hair Treatment A treatment having the following formulation was prepared. This treatment is a complex with a white jellyfish polysaccharide and behenamidopropyl dimethylamine. there were.

Component Blending amount (% by weight)
------------------------------------
Part A Cosmetic composition of Example 1 0.3
Purified water 10.0
Part B Plandool-LG2 (Nippon Seika) 0.5
Propanediol 3.0
Behenamidopropyldimethylamine 1.5
Cetanol 2.2
Stearyl alcohol 0.8
Hydrogenated rapeseed oil alcohol 0.5
Neopentyl glycol diethylhexanoate 0.8
Jojoba seed oil 1.0
Glyceryl stearate 0.4
Propylparaben 0.1
Cocamide MEA 0.8
Caesarpinia spinosa hydroxypropyltrimonium chloride 0.1
Rice bran wax 0.5
Glycerin 1.0
Part C Methylparaben 0.1
Lactic acid 0.4
Purified water Amount to be 100 in total Part D
Purified water 10.0
------------------------------------
(Preparation method)
Part B and part C were heated to about 80 ° C. and dissolved. Part A was mixed with stirring with a propeller to prepare a nanovesicle solution. C part was gradually added to B part and mixed uniformly. At about 50 ° C., A part and D part were added with stirring to make uniform.

Example 41 Harikoshi Treatment A treatment having the following formulation was prepared. This treatment repaired damage from the inside of the hair, gave a harsh feeling, increased the volume, and suppressed discoloration of colored hair.

Component Blending amount (% by weight)
-----------------------------------
Part A Cosmetic composition of Example 3 0.5
Purified water 10.0
Part B Plandool-ISS (Nihon Seika) 0.3
Cetanol 1.0
Elcalactone DES (Nippon Seika) 2.5
Behentrimonium chloride (80%) 1.0
DPG 0.4
Phenoxyethanol 0.3
Neosolute-EHS (Nippon Seika) 2.0
Part C Hydroxyethylcellulose 0.3
Tremoist-SL (Nippon Seika) 1.0
Phenoxyethanol 0.4
EDTA-2Na 0.05
Purified water Total amount of 100 -----------------------------------
(Preparation method)
Part A was mixed with stirring with a propeller to prepare a nanovesicle solution. Part C was heated to about 60 ° C. and dissolved. Next, part B was heated to about 80 ° C. and dissolved. Part B was added while stirring part C and mixed uniformly, then cooled to about 40 ° C. and part A was added to make it uniform.

Example 42 Washing Treatment A treatment having the following formulation was prepared. This treatment had a damage care effect inside the hair, gave a moist feel to the hair, and provided a volume-up effect.

Component Blending amount (% by weight)
------------------------------------
Part A Cosmetic composition of Example 4 1.5
Purified water 10.0
Part B Sunflower oil fatty acid phytosteryl (Plandool-SUN: Nippon Seika) 3.0
Cetrimonium chloride (70%) 1.0
Stearamidopropyldimethylamine 0.5
Steartrimonium chloride 0.8
Cetyl ethylhexanoate (NS-CIO: Nippon Seika) 1.5
Behenyl alcohol 0.3
Hydrogenated rapeseed oil alcohol 0.3
Myristyl alcohol 0.3
LUSPLAN SR-DM4 (Nippon Seika) 0.5
Behendimonium ethyl stearyl phosphate 0.1
Dimethicone (1 million cs) 1.0
Glycerin 1.0
Propanediol 0.3
Part C Purified water Total amount of 100 Malic acid 0.2
Hydroxyethyl cellulose 0.2
Part D Tremoist-SL (Nippon Seika) 1.0
Purified water 10.0
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(Preparation method)
Part B and part C were heated to about 80 ° C. and dissolved. Part A was mixed with stirring with a propeller to prepare a nanovesicle solution. C part was gradually added to B part and mixed uniformly. At about 50 ° C., A part and D part were added with stirring to make uniform.

2 is a TEM image of a vesicle obtained using the cosmetic composition of Example 2.

Claims (6)

It consists of the following components (A) to (C), the weight ratio of the component (A) to the component (B) is 9: 1 to 6: 4, and the total content of the components (A) and (B) Is 2 to 30% by weight, and the content of component (C) is 70 to 98% by weight.
(A) Mannosylerythritol lipid having a structure represented by the following general formula (1)
(In the formula, R1 and R2 represent hydrogen or an aliphatic acyl group having 2 to 24 carbon atoms (but do not take hydrogen at the same time), R3 and R4 represent hydrogen or an acetyl group, and R5 represents hydrogen or carbon number. Represents 2 to 24 aliphatic acyl groups.)
(B) Phospholipid (C) Polyhydric alcohol A cosmetic comprising the cosmetic composition according to claim 1. A cosmetic obtained by dispersing the cosmetic composition according to claim 1 in water and forming a vesicle with the component (A) and the component (B). Furthermore, it contains an oligomer ester of polyglycerin having an average polymerization degree of 2 to 15 calculated from a linear or branched divalent carboxylic acid having 14 to 22 carbon atoms and a hydroxyl value. 4. The cosmetic composition or cosmetic according to any one of 3 above. Furthermore, polyhydric alcohol is contained, Cosmetics in any one of Claims 2-4 characterized by the above-mentioned. Furthermore, the composition for cosmetics or cosmetics in any one of Claims 1-5 characterized by containing a tocopherol.