JP6971072B2 - Cosmetic composition containing mannosyl erythritol lipid - Google Patents

Description

The present invention relates to a cosmetic composition containing mannosyl erythritol lipid (hereinafter, may be simply referred to as MEL), and a cosmetic using the cosmetic composition.

The stratum corneum is located in the outermost layer of the skin and has an important function of preventing foreign substances and irritation from the outside. On the other hand, this barrier function suggests that the penetration of the active ingredient is hindered in the use of cosmetics and external skin preparations. From this point of view, attempts have been made to improve the permeability by encapsulating the active ingredient in a capsule such as a liposome. At this time, the smaller the particle size of the capsule, the more advantageous it is to improve the permeability.

Glycolipid-based biosurfactants are produced by bacteria and yeast, and many types of substances have been reported. Such glycolipid-based biosurfactants are not only highly biodegradable, low in toxicity and environmentally friendly, but also have excellent physiological functions. Mannosylerythritol lipid (MEL) is known as one of the representative glycolipid-based biosurfactants. Since MEL has physiological activities such as improvement of rough skin, anti-inflammatory / anti-allergy, hair growth / hair growth, etc., it is very useful as an active ingredient of cosmetics and external skin preparations (for example, Patent Documents 1 to 3).

Patent Document 4 describes that MEL itself forms a vesicle, but the particle size when dispersed in water has not been investigated. Patent Document 5 discloses a liposome composed of MEL and phospholipid, but according to this patent, a procedure of dissolving MEL and phospholipid in ethanol and removing ethanol under reduced pressure is required to prepare the liposome. be. Patent Document 6 describes an oil-in-water emulsified cosmetic composition containing MEL, a phospholipid, a polyhydric alcohol and water, and describes that this emulsified composition can form a vesicle structure. However, the examples of this patent only describe examples of emulsions using lecithin hydroxide as a phospholipid. Further, the particle size of the obtained emulsified composition is 200 nm or more, and it has not been confirmed whether or not the emulsified particles form vesicles. It should be noted that paragraphs 0110 to 0111 of this patent describe that a high pressure emulsifier is required for the formation of vesicles.

Re-table 2007-060956 Japanese Patent Application Laid-Open No. 2005-068015 JP-A-2003-261424 JP-A-2009-154121 JP-A-2005-281146 JP-A-2009-275017

The first object of the present invention is to provide a cosmetic having a vesicle containing MEL, having a small particle size of the vesicle, having a transparent appearance, and having excellent stability over time. .. In addition, to solve this problem, it is possible to use phospholipids that are as safe and environmentally friendly as biosurfactants, and that vesicles can be easily produced without complicated operations or special machines such as high-pressure emulsifiers. It is mentioned as a subject of the invention.

（式中、Ｒ１、Ｒ２は水素又は炭素数２〜２４の脂肪族アシル基を表す（ただし同時に水素はとらない）。また、Ｒ３、Ｒ４は水素又はアセチル基を表し、Ｒ５は水素又は炭素数２〜２４の脂肪族アシル基を表す。）
（Ｂ）リン脂質
（Ｃ）多価アルコール As a result of diligent studies to solve the above problems, the present inventors have the following components (A) to (C), and the weight ratio of the component (A) to the component (B) is 9: 1 to 6: 4, the total content of the component (A) and the component (B) is 2 to 30% by weight, and the content of the component (C) is 70 to 98% by weight. We have found that the above problems can be solved by using a material composition, and have completed the present invention.

(A) Mannosyl erythritol lipid having a structure represented by the following general formula (1)

(In the formula, R1 and R2 represent hydrogen or an aliphatic acyl group having 2 to 24 carbon atoms (however, hydrogen is not taken at the same time). In addition, R3 and R4 represent hydrogen or acetyl groups, and R5 represents hydrogen or carbon atoms. Represents 2 to 24 aliphatic acyl groups.)
(B) Phospholipid (C) Polyhydric alcohol

In the cosmetic composition of the present invention, a MEL-containing vesicle having a particle diameter of 100 nm or less is formed by a simple operation of dispersing in water with a low stirring force, and the obtained cosmetic has a transparent appearance. Excellent stability over time.

（式中、Ｒ１、Ｒ２は水素又は炭素数２〜２４の脂肪族アシル基を表す（ただし同時に水素はとらない）。また、Ｒ３、Ｒ４は水素又はアセチル基を表し、Ｒ５は水素又は炭素数２〜２４の脂肪族アシル基を表す。） The component (A) mannosyl erythritol lipid used in the present invention is a compound represented by the following general formula (1).

(In the formula, R1 and R2 represent hydrogen or an aliphatic acyl group having 2 to 24 carbon atoms (however, hydrogen is not taken at the same time). In addition, R3 and R4 represent hydrogen or acetyl groups, and R5 represents hydrogen or carbon atoms. Represents 2 to 24 aliphatic acyl groups.)

R1, R2, and R5 of the general formula (1) may be an aliphatic acyl group having 2 to 24 carbon atoms, and are not particularly limited, but are preferably saturated or unsaturated acyl groups having 6 to 20 carbon atoms. ..

The mannosyl erythritol lipid of the general formula (1) includes various compounds depending on the bonding position of the acyl group or the acetyl group, but generally there are four types of MEL-A, MEL-B, MEL-C and MEL-D. Widely known. In MEL-A, R1 and R2 of the general formula (1) are acyl groups, R3 and R4 are acetyl groups, and R5 is a hydrogen compound. In MEL-B, R1 and R2 of the general formula (1) are an acyl group, R3 is a hydrogen, R4 is an acetyl group, and R5 is a hydrogen compound. In MEL-C, R1 and R2 of the general formula (1) are acyl groups, R3 is an acetyl group, R4 is hydrogen, and R5 is a hydrogen compound. In MEL-D, R1 and R2 of the general formula (1) are acyl groups, R3 and R4 are hydrogens, and R5 is a hydrogen compound. Although any of these can be used in the present invention, MEL-B or MEL-C is preferable, and MEL-B is most preferable in terms of availability and the effects of the invention.

The method for producing mannosyl erythritol lipid is not particularly limited, and the mannosyl erythritol lipid can be produced by a known production method. Generally, a fermentation method using a microorganism is known, and for example, it may be produced by the method described in JP-A-2009-275017.

The component (B) phospholipid used in the present invention includes diacylglycerophospholipids having polar groups such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, and phosphatidylic acid; soybeans, rapeseed, sunflowers, saflowers, and peanuts. , Cottonseed, corn, rice, barley and other plants, natural lecithin obtained from egg yolk and their hydrogenated additives can be exemplified. Further, these may be derivatives modified with a polyoxyalkylene group such as polyethylene glycol. These phospholipids may be used alone or in combination of two or more. Of these, natural lecithin and hydrogenated additives thereof are preferable from the viewpoint of availability and the effect of the present invention. As natural lecithin, those having different phosphatidylcholine (hereinafter, PC) contents depending on the degree of purification are commercially available, but in the present invention, the PC content is 20 to 99%, more preferably 40 to 90%, most preferably. It is recommended to use 50 to 80% of the above.

Examples of the component (C) polyhydric alcohol used in the present invention include ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, and 2,3-butylene. Glycol, tetramethylene glycol, hexylene glycol, octylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, etc. Divalent alcohols; trivalent alcohols such as glycerin, trimethylolpropane, 1,2,6-hexanetriol; sugar alcohols such as sorbitol, xylitol, erythritol, martitol, mannitol; ethylglycerin, butylglycerin, hexylglycerin , Ethylhexyl glycerin and other glyceryl ethers; diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, polyglycerin and other polyhydric alcohol polymers. And so on. These may be used alone or in combination of two or more. Of these, glycerin, propylene glycol, 1,3-propanediol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptandiol, 1 , 2-Octandiol is preferred, 1,2-pentanediol, 1,3-butylene glycol and glycerin are most preferred.

The cosmetic composition of the present invention comprises the above-mentioned components (A) to (C), and the weight ratio of the component (A) to the component (B) is 9: 1 to 6: 4, and the component (A) is used. The total content of the component (B) is 2 to 30% by weight, and the content of the component (C) is 70 to 98% by weight. The method for producing the cosmetic composition of the present invention is not particularly limited, and can be produced, for example, by stirring and mixing the components (A) to (C) at about 60 ° C.

The cosmetic composition thus obtained can form a vesicle containing MEL only by dispersing it in water. At this time, a device having a high stirring power such as a homomixer is not required, and manufacturing with a stirring power such as a propeller or a stirrer is possible. The particle size of the vesicle obtained by using the cosmetic composition of the present invention is 100 nm or less, the appearance of the obtained cosmetic is transparent, and the stability over time is also excellent. If the weight ratio of the component (A) to the component (B) is out of the range of 9: 1 to 6: 4, a vesicle having a sufficiently small particle size cannot be formed, and the appearance and stability over time are not sufficient. Further, if the total content of the component (A) and the component (B) is less than 2% by weight, the effect of the present invention cannot be sufficiently exerted, and if it is more than 30% by weight, the component (A) and the component (B). ) Is not sufficiently dissolved in the component (C), and the effect of the present invention cannot be exhibited.

The amount of the cosmetic composition of the present invention to be blended in a cosmetic is not particularly limited, but is usually 0.01 to 30% by weight, preferably 0. from the viewpoint of the appearance of the obtained cosmetic and the stability over time. It is 05 to 15% by weight, more preferably 0.1 to 10% by weight.

The cosmetic of the present invention has an average degree of polymerization of 2 calculated from a linear or branched divalent carboxylic acid having 14 to 22 carbon atoms and a hydroxyl value from the viewpoint of further improving the appearance and stability of the cosmetic over time. It may contain an oligomer ester with ~ 15 polyglycerin. As such an oligomer ester, for example, (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 is commercially available from Nippon Seika Co., Ltd. under the trade names of Neosolue-Aqua and Neosolue-AquaS. By containing such a component, the cosmetic of the present invention can maintain its appearance and stability over time even when an organic acid such as citric acid and a polysaccharide such as sodium hyaluronate and xanthan gum coexist. Such an oligomer ester is usually preferably used in an amount of 0.01 to 10% by weight, preferably about 0.05 to 5% by weight.

The cosmetic of the present invention may contain a polyhydric alcohol from the viewpoint of further improving the appearance and stability of the cosmetic over time. Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, tetramethylene glycol, and hexylene glycol. Divalent alcohols such as octylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol; glycerin, trimethylol Trivalent alcohols such as propane, 1,2,6-hexanetriol; sugar alcohols such as sorbitol, xylitol, erythritol, martitol, mannitol; glyceryl ethers such as ethyl glycerin, butyl glycerin, hexyl glycerin, ethyl hexyl glycerin; diethylene glycol, Examples thereof include polyhydric alcohol polymers such as triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, and polyglycerin. These may be used alone or in combination of two or more. Of these, polyhydric alcohols having 3 to 8 carbon atoms are preferable, and glycerin, propylene glycol, 1,3-propanediol, dipropylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,2-butylene glycol, and 1,2-butylene glycol are preferable. Pentandiol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol and the like are more preferable. By containing such a component, the cosmetic of the present invention can maintain its appearance and stability over time even when an organic acid such as citric acid and a polysaccharide such as sodium hyaluronate and xanthan gum coexist. Such a polyhydric alcohol is usually used in an amount of 0.1 to 70% by weight, preferably about 0.5 to 50% by weight.

In addition to the cosmetic composition of the present invention, the cosmetic of the present invention includes additive components such as oily bases, surfactants, alcohols, moisturizers, which are added to water and ordinary cosmetics as needed. Polymer / thickening / gelling agent, antioxidant, preservative, bactericidal agent, chelating agent, pH adjuster / acid / alkali, ultraviolet absorber, whitening agent, solvent, keratin peeling / dissolving agent, antipruritic agent, anti-inflammatory Agents, antiperspirants, refreshing agents, antihistamines, astringents, stimulants, hair growth agents / blood circulation promoters, reducing agents / oxidizing agents, polymer powders, hydroxy acids, vitamins and their derivatives, saccharides and their derivatives Kinds, organic acids, enzymes, nucleic acids, hormones, inorganic powders, fragrances, pigments and the like can be added. These components may be embedded inside a vesicle containing MEL.

Oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, araquil alcohol, behenyl alcohol, jojoba alcohol, chimil alcohol, seraquil alcohol, bacillus alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol, dimerdiol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Higher grades such as palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eikosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long chain branched fatty acids, dimer acid, hydrogenated dimer acid, etc. Fatty acids and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium and sodium salts, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin , Α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalane, vaseline, solid paraffin and other hydrocarbons; candelilla wax, carnauba wax, rice wax, wood wax, honey wax, montan Waxes such as wax, ozokelite, selecin, paraffin wax, microcrystallin wax, petrolatum, fishertroph wax, polyethylene wax, ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, Avocado oil, sesame oil, brown oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rose hip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, Vegetable fats and oils such as wheat germ oil, flaxseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef fat, milk fat , Horse fat, egg yolk oil, mink oil, turtle oil and other animal oils; whale wax, lanolin, orange raffy oil and other animal waxes; liquid lanolin, reduced lanoli Lanolins such as adsorption-purified lanolin, lanolin acetate, liquid acetate lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine , Sphingophosphory acids such as phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids. , Phosphoric lipid derivatives such as partially hydrogenated egg yolk phospholipids; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, Cholesteryl isostearate, cholesteryl oleate, di-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (cholesteryl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl). / Behenyl / Octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), acylsarcosine alkyl esters such as N-lauroyl sarcosin isopropyl, cholesteryl 12-hydroxystearate, fatty acid cholesteryl of macadamia nut oil, fatty acid phytosteryl of macadamia nut oil. , Phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl and other sterol esters; Complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl parimitinate, octyldodecyl palmitate, cetyl octanate, hexyldecyl octanoate, isotoridesyl isononanoate, isononyl isononanoate, octyl isononanoate. Isotridecyl, Isodecyl neopentate, Isotridecyl neopentate, Isostearyl neopentate, Oku neodecanoate Tildodecyl, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, cured castor oil isostearate, ethyl oleate, avocado oil fatty acid ethyl, Isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, sebacic acid Monoalcohol carboxylic acid esters such as dioctyl, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate; cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, γ- Oxyacid esters such as erucalactone; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (capric acid / capric acid) glyceryl, tri (capric acid / capric acid / myristic acid / stearic acid) ) Glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl beecosanate, glyceryl trioctanoate, trimethylol propane triisostearate, neopentyl glycol dioctanoate, neo dicaprate Pentyl glycol, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosinpentaerythrityl, ditrimethylolpropane triethylhexanoic acid, (isostearic acid / Sevacinic acid) ditrimethylol propane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / logonic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostear) Acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, distearic acid Polyhydric alcohol fatty acid esters such as glycol (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineeopentanoic acid, 2,4-diethyl-1,5-pentanediol dineeopentanoic acid; alkyl such as dicaprylyl ether Ethers; diisopropyl dimergilinoleate, diisostearyl dimergilinolate, dimerjilinol acid di (isostearyl / phytosteryl), dimerjilinol acid (phytosteryl / behenyl), dimerjilinol acid (phytosteryl / isostearyl / cetyl) / Stearyl / Behenyl), Dimer dilinoleic acid Dimerjilinoleil, Dimersyreinoleyl diisostearate, Dimerjilinoleyl hydrogenated rosin condensate, Dimerjilinol acid-cured castor oil, Hydroxyalkyl Dimerjilinoleyl ether and other dimers. Acid or dimerdiol derivatives; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid mono Fatty acid alkanolamides such as isopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), Highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol cloth Amino-modified silicones such as polymers, silicone resins, silicone rubbers, aminopropyl dimethicone and amodimethicone, polyether-modified silicones such as cation-modified silicones and dimethicone copolyols, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, and phosphoric acids. Modified Silicone, Sulfate Modified Silicone, Alkyl Modified Silicone, Fatty Acid Modified Silicone, Alkyl Ether Modified Silicone, Amino Acid Modified Silicone, Peptide Modified Silicone, Fluorine Modified Silicone, Catio Silicones such as N-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, and polysiloxane / oxyalkylene copolymers. Classes; Fluoro-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether are preferable.

Examples of the moisturizing agent / feeling improving agent include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, and the like. Polypolymers such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and its polymers; diethylene glycol monoethyl ether Glycol alkyl ethers such as (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10, polyglyceryl-10 tetradecanedioate, cyclohexanedicarboxylic acid Water-soluble esters such as bisethoxydiglycol; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, martitol; glucose, fructose, galactose, mannose, treose, xylose, arabinose, fucose, ribose, deoxyribose, maltose Trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated and hydroxyalkylated), β-glucan, chitin, chitosan, Sugars and derivatives such as heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate , Caronine sulfate, keratosulfate, dermatane sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; organic acids such as citric acid, tartrate acid, lactic acid and salts thereof; urea; 2-pyrrolidone-5 -Dicarboxylic acids and salts such as sodium thereof; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, ass Amino acids such as paragin, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and their salts; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, hydrolyzed collagen, Hydroxypropylammonium chloride Hydrolyzed collagen, elastin-degraded peptide, keratin-degraded peptide, hydrolyzed keratin, conchiolin-degraded peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, wheat protein Protein peptides such as degrading peptides, hydrolyzed wheat proteins, casein-degrading peptides, acylated peptides and their derivatives; acylated peptides such as palmitoyl oligopeptides, palmitoyl pentapeptides and palmitoyl tetrapeptides; silylated peptides; lactic acid bacteria culture solution. , Yeast extract, eggshell membrane protein, submandibular gland mutin, hypotaurine, sesame lignan glycoside, glutathione, albumin, lactose; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extract, hamamelis water, hechima Animal / plant extracts such as water, chamomile extract, kanzo extract, comfrey extract, silk extract, Izayoi rose extract, sardine extract, eucalyptus extract, and melilot extract, natural ceramide (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides, sphingolipeptides, ceramides and ceramides such as sugar ceramide-containing extracts are preferred.

Preferred examples of the surfactant include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymer surfactants. The HLB of the surfactant is not particularly limited and can be used from a low HLB of about 1 to a high HLB of about 20, and it is also preferable to combine a low HLB and a high HLB. Examples of preferred surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulphates such as sodium lauryl sulphate, triethanolamine lauryl sulphate and ammonium lauryl sulphate; laureth. Polyoxyethylene alkyl sulfates such as sodium sulphate, triethanolamine laures sulphate; sodium cocoylmethyl taurine, potassium cocoyl methyl taurine, sodium lauroyl methyl taurine, sodium myristylmethyl taurine, sodium lauroyl methyl alanine, sodium lauroyl sulcocin, sodium lauroyl sulcocin triethanol. Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroyl glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine. , Acyl amino acid salts such as lysine Na dilauroyl glutamate; Polyoxyethylene alkyl ether acetates such as sodium laures acetate; Succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; Polyoxyethylene fatty amine sulfate; fatty acid alkanolamide sulfate; hardened coconut oil fatty acid fatty acid glyceride sulfate such as sodium glycerin sulfate; alkylbenzene polyoxyethylene sulfate; olefin sulfonate such as α-olefin sulfonate sodium; Alkyl sulfosuccinates such as lauryl disodium acid, sodium dioctyl sulfosuccinate; alkyl ether sulfosuccinates such as laures disodium sulfosuccinate, monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; tetradecyl Alkyl benzene sulfonates such as sodium benzene sulfonate, triethanolamine tetradecyl benzene sulfonic acid; alkyl naphthalene sulfonate; alkane sulfonate; α-sulfo fatty acid methyl ester salt; acyl isethionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetate; Alkyl ether phosphate such as sodium laureth phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monoolesphosphate; Alkyl phosphate such as potassium lauryl phosphate; Sodium casein; Alkyl aryl ether Phosphate; fatty acid amide ether phosphate; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, sulfate-modified silicone; Non-ionic surfactants include laures (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steares (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), and isosteares (poly). Polyoxyethylene alkyl ethers with various polyoxyethylene additions such as oxyethylene isostearyl ethers), octyldodeces (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkylphenyl ethers; polyoxyethylene hydrogenated castor oil, poly Oxyethylene castor oil, polyoxyethylene cured castor oil monoisostearate, polyoxyethylene cured castor oil triisostearate, polyoxyethylene cured castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene cured castor oil maleic acid, etc. Himashima oil and hardened Himashima oil derivative; Polyoxyethylene phytosterol; Polyoxyethylene cholesterol; Polyoxyethylene cholestanol; Polyoxyethylene lanolin; Polyoxyethylene reduced lanolin; Polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / Polyoxyethylene / polyoxypropylene alkyl such as polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether, etc. Ether; Polyoxyethylene / Polyoxypropylene glycol; (Poly) glycerin such as PPG-9 diglyceryl Polyoxypropylene glycol; Glyceryl stearate, Glyceryl isostearate, PA Glyceryl luminate, Glyceryl myristate, Glyceryl oleate, Glyceryl coconut oil, Glycerin monocotton seed oil, Glycerin monoerkaate, Glycerin sesquioleate, α, α'-Glycerin pyroglutamate oleate, Glycerin monostearate, etc. Partial esters of glycerin fatty acids; polyglyceryl-2 stearate, 3, 4, 5, 5, 6, 8, 10, distearate polyglyceryl-6, 10, tristearate polyglyceryl-2, decastearate polyglyceryl -10, Polyglyceryl-2 isostearate-2, 3, 4, 5, 6, 8, 8, 10, Polyglyceryl diisostearate-2 (diglyceryl diisostearate), 3, 10, Polyglyceryl triisostearate- 2, Polyglyceryl-2 tetraisostearate, Polyglyceryl-10 decaisostearate, Polyglyceryl-2 oleate 3, 4, 4, 5, 6, 8, 10, Dioleate polyglyceryl-6, Trioleate polyglyceryl -2, Polyglycerin fatty acid ester such as polyglyceryl-10 decaoreate; ethylene glycol monofatty acid ester such as ethylene glycol monostearate; propylene glycol monofatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid Estares; multi-toll partial fatty acid esters; multi-toll ethers; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, penta-2 -Sorbitan fatty acid esters such as diglycerol sorbitan ethylhexylate and diglycerol sorbitan tetra-2-ethylhexylate; sugar derivative partial esters such as sucrose fatty acid ester, methylglucoside fatty acid ester and trehalose undecylate; alkyl glucosides such as caprylyl glucoside; Alkyl polyglycoside; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate and other polyoxyethylene fatty acid monos and diesters; polyoxy Ethylene / propylene Recall fatty acid ester; polyoxyethylene glycerin fatty acid ester such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene glycerin fatty acid ester; polyoxyethylene sorbitan Polyoxyethylene sorbitan fatty acid esters such as monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate. , Polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate and the like; polyoxyethylene sorbitol fatty acid ester; polyoxyethylene methyl glucoside fatty acid ester; polyoxyethylene alkyl ether fatty acid ester; Ethylene animal and vegetable oils and fats; alkyl glyceryl ethers such as isostearyl glyceryl ether, kimil alcohol, ceracyl alcohol, bacillic alcohol; polyhydric alcohol alkyl ether; polyoxyethylene alkylamine; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine Condensates; Natural surfactants such as saponin and sophorolipid; Polyoxyethylene fatty acid amide; Palm oil fatty acid monoethanolamide (cocamide MEA), Palm oil fatty acid diethanolamide (cocamide DEA), Lauric acid monoethanolamide (lauramide MEA) ), Lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA) Fatty acid alkanolamides such as; alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, behenamine oxide; alkylethoxydimethylamine oxides; polyoxyethylene alkyl mercaptans; polyether modification such as dimethicone copolyethylenes. Silicone, polysiloxane / oxyalkylene copolymer, polyglycerin modification Silicone-based nonionic surfactants such as silicones and sugar-modified silicones; For cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, stealtrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride; Alkyltrimethylammonium bromide such as stearyltrimonium bromide; Dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amide amines such as stearamide propyldimethylamine and stearamide ethyldiethylamine and salts thereof; stearoxypropyldimethyl Alkyl ether amines such as amines and their salts or quaternary salts; fatty acid amide-type quaternary ammonium salts such as ethyl sulfate long chain branched fatty acids (12-31) aminopropylethyldimethylammonium, ethylsulfate lanolin fatty acid aminopropylethyldimethylammonium; Polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salts; fatty acid amide guanidium salts; alkyl etheraminemonium salts; alkyltrialkylene glycol ammonium salts; benzalconium salts; benzethonium salts; cetylpyridinium chloride, etc. Pyridinium salt; imidazolinium salt; alkylisoquinolinium salt; dialkylmoriphonium salt; polyamine fatty acid derivative; amino-modified silicone such as aminopropyldimethicone and amodimethicone, cationic-modified silicone, cationic-modified and polyether-modified silicone, amino Silicone-based cationic surfactants such as modified and polyether-modified silicones; N-alkyl-N, N-dimethylaminomic acid betaines such as lauryl betaine (lauryl dimethylaminoacetic acid betaine) for amphoteric surfactants; cocamidopropyl Fatains such as betaine and lauramidopropyl betaine Alkylamide alkyl-N, N-dimethyl amino acid betaine; imidazoline-type betaine such as sodium cocoamphoacetate and sodium lauroammonium acetate; alkylsulfobetaine such as alkyldimethyltaurin; alkyldimethylaminoethanol sulfate ester and the like Sulfate-type betaine; Phosphate-type betaine such as alkyldimethylaminoethanol phosphate ester; Sphingophosphory lipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin, lysolecithin , Hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as lecithin hydroxide; , Polyvinyl alcohol, sodium alginate, starch derivative, tragant gum, acrylic acid / alkyl methacrylic acid copolymer; various silicone-based surfactants are preferable.

Examples of the polymer / thickener / gelling agent include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, farcerelan, karaya gum, trolley aoi, cara gum, tragant gum, pectin, pectic acid and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potatoes, wheat; xanthan gum, dextran, succinoglucan, curdran, hyaluronic acid and its salts, zansan gum, purulan, gellan gum, chitin , Chitosan, agar, casso extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and salts such as sodium thereof, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethyl Ammium sulfate cellulose, crystalline cellulose, cellulose such as cellulose powder and derivatives thereof; starch-based polymers such as soluble starch, carboxymethyl starch, methyl hydroxypropyl starch, methyl starch, hydroxypropyltrimonium chloride starch, octenyl succinate corn starch aluminum, etc. Alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpidridone / vinyl alcohol copolymer, polyvinylmethyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene. Polyoxypropylene copolymer; (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (Acrylate / stearyl acrylate / ethylamine methacrylate) copolymer and other amphoteric methacrylic acid ester copolymers; (dimethicone / vinyldimethicone) cloth Polymers, (alkyl acrylate / diacetone acrylamide) copolymers, (alkyl acrylate / diacetone acrylamide) copolymers AMP; partially saponified polyvinyl acetates, maleic acid copolymers; vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymers; Acrylic resin alkanolamine; polyester, water-dispersible polyester; polya Crylamide; polyacrylic acid ester copolymer such as ethyl polyacrylic acid, carboxyvinyl polymer, salt such as polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; both acrylic acid and alkyl methacrylic acid. Polymers: cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid such as polyquaterium-39. -Diallyldimethylammonium chloride-acrylamide copolymer, acrylic acid-cationized methacrylic acid ester copolymer, acrylic acid-cationized methacrylic acid amide copolymer, polyquaterium-47 and other acrylic acid-methyl acrylate-chloride Methalamide propyltrimethylammonium copolymers, choline chloride ester polymers; cationized oligosaccharides, cationized dextran, cationized polysaccharides such as guarhydroxypropyltrimonium chloride; polyethyleneimine; cationic polymers; polyquaternium-51 and the like. 2-Polymer of methacryloyloxyethyl phosphorylcholine and polymer with butyl methacrylate copolymer, etc .; acrylic resin emulsion, polyacrylic acid ethyl emulsion, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic Polymer emulsions such as latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and The salt; dextrin fatty acid ester such as dextrin palmitate, dextrin myristinate; anhydrous silicic acid, fumes silica (ultrafine anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, dialkylphosphate metal salt, Bentonite, hectrite, organically modified clay minerals, sucrose fatty acid esters, fructo-oligosaccharide fatty acid esters are preferred.

Examples of solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol and isopentyldiol. Kind: Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate, ethylene glycol dissuccinate; benzyl Preferred examples include propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation freon; LPG, dimethyl ether, carbon dioxide gas and the like.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; ascorbic acid derivatives such as propyl bisulfate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; Sodium bisulfite and other sulfites; Sodium bisulfite and other sulfite hydrogen salts; Sodium bisulfite and other thiosulfates; Metahydrosulfite hydrogen salts; Thiotaurine, hypotaurine; Thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferred. Is mentioned as. As the reducing agent, thioglycolic acid, cysteine, cysteamine and the like are preferable. As the oxidizing agent, hydrogen peroxide solution, ammonium persulfate, sodium bromate, percarbonate and the like are preferable.

Examples of antibacterial agents or preservatives include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane. 1,2-Alcandiols such as diols; Alkylglyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); Salicylic acid; Sodium benzoate; Isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; Linium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acidamides, quaternary ammonium salts; trichlorocarbanide, zincpyrythion, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, glucon Chlorhexidine acid acid, halocarban, hexachlorophen, hinokithiol; other phenols such as phenol, isopropylphenol, cresol, timol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion However, when used as an antibacterial agent or an antiseptic for the purpose of antiseptic, from the viewpoint of safety of cosmetics or external skin preparations, phenoxyethanol; 1,2-pentanediol, 1,2-hexane It is more preferable to use 1,2-alkanediols such as diols and 1,2-octanediols; and alkylglyceryl ethers such as 2-ethylhexyl glyceryl ethers.

Examples of the chelating agent include edetates (ethylenediamine tetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediamine triacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; ethidronic acid and the like. Phosphonic acid and salts such as sodium salts thereof; Sodium oxalate; Polypolyamino acids such as polyaspartic acid and polyglutamic acid; Sodium polyphosphate, sodium metaphosphate, phosphate; sodium citrate, citric acid, alanine, dihydroxyethylglycine , Gluconic acid, ascorbic acid, succinic acid, tartrate acid are preferred. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol. Amin, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Preferred are sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate and ammonium carbonate.

Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, white mica, gold mica, synthetic mica, red mica, black mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, cay. Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal salt of tungsten acid, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (eg zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, dark blue, carbon black, titanium oxide, fine powder and ultrafine titanium oxide, zinc oxide , Fine particles and ultrafine zinc oxide, alumina, silica, fumigant silica (ultrafine anhydrous silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine gold mica, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with silicones such as hydrogen silicone and cyclic hydrogen silicone or other surface treatment agents such as silane or titanium coupling agents to make them hydrophobic. Inorganic powder such as hydrophilized powder; starch, cellulose, nylon powder, polyethylene powder, polymethylmethacrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate -Polymethylmethacrylate laminated powder, polyethylene terephthalate, aluminum, epoxy laminated powder, etc., urethane powder, silicone powder, Teflon (registered trademark) powder, and other organic powders and surface-treated powders of various sizes and shapes, organic and inorganic Composite powders are preferred. Inorganic salts include sodium chloride-containing salts such as salt, normal salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, ginger, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, etc. Aluminum / potassium sulfate (myoban), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na / 2Na / 3Na phosphate, phosphate Potassiums, calcium phosphates, magnesium phosphates are preferred.

Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoate ethyl. Anthranic acid-based UV absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl esters, N, N-dimethylparaaminobenzoic acid ethyl esters; Anthranilic acid-based UV absorbers such as homomentyl-N-acetylanthranilate; salicylic acid. And salicylic acid-based ultraviolet absorbers such as sodium salts, amilsalicylate, menthylsalicylate, homomentylsalicylate, octylsalicylate, phenylsalicylate, benzylsalicylate, p-isopropanolphenylsalicylate; octylcinnamate, ethyl-4-isopropylsinnate, methyl. -2,5-Diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy Synnamete, 2-Ethylhexyl p-methoxysinamate (octyl paramethoxysilicate), 2-ethoxyethyl-p-methoxysinamate (sinoxate), cyclohexyl-p-methoxysinamate, ethyl-α-cyano-β-phenyl Ceramic acid-based ultraviolet absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate (octocrine), glycerylmono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and its derivatives; 2, 4-Dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-Methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' Benzophenones such as −phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone System UV absorbers; 3- (4'-methylbenziliden) -d, l-phenyl, 3-benziliden-d, l-phenyl; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 -Methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoilmethane; 5-( 3,3-Dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivative such as 4-t-butylmethoxydibenzoylmethane; octylriazone; urocanic acid derivative such as urocanic acid and ethyl urocanate 2- (2'-Hydroxy-5'-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentandione, dimethoxybenzilidendioxoimidazolidinepropionic acid Preferred examples include hydridein derivatives such as 2-ethylhexyl, phenylbenzimidazole sulfonic acid, terephthalylidenedicanfursulfonic acid, drometrizoletrisiloxane, methyl anthranilate, rutin and its derivatives, orizanol and its derivatives.

Examples of vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxin hydrochloride, pyridoxin dioctanoate, pyridoxin dipalmitate, and the like. Flavin adenine dinucleotide, cyanocobalamine, folic acid, nicotinic acids such as nicotinic acid amide and benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin E such as β, γ, δ-tocopherol; Other vitamins such as pantothenic acid and biotin; Ascorbic acid phosphate ester salt such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt, ascorbic acid tetra Ascorbic acid fatty acid ester such as isopalmitic acid ester, ascorbic stearate, ascorbic palmitate, ascorbic dipalmitate, ascorbic acid alkyl ether such as ethyl ascorbic acid ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and its fatty acid ester. , Ascorbic acid derivatives such as tocopheryl phosphate ascorbic; vitamin derivatives such as tocopherol derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleic acid, tocopherol ferulate, tocopherol phosphate ester, tocotrienol, and other various vitamin derivatives are preferable. Is mentioned as.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokithiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednison, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract. , Plant extracts such as Honoha extract are preferred. As hair growth agents, blood circulation promoters and stimulants, plant extracts and tinctures such as senburi extract, sugar cane tincture, ginger tincture, ginger extract, cantalis tincture; , Borneol, cyclanderate, cinnaridine, trazoline, acetylcholine, verapamil, cepharanthin, γ-orizanol, cepharanthin, vitamin E and derivatives such as tocopherol nicotinate / tocopherol acetate, γ-orizanol, nicotinic acid and nicotinic acid amide / benzyl nicotinate. Derivatives such as ester inositol hexanicotinate and nicotin alcohol, allantin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivative, stigmasterol or stigmasterol and its glycosyl, minoxidyl are preferable. Is mentioned as. As the hormones, estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like are preferable. Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cold sensitizers, warming agents, wound healing promoters, stimulants, painkillers, cell activators, etc. include retinols, retinoic acids, retinoins. Tocopheryl acid; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, hydroxycapric acid, long-chain α-hydroxy fatty acid, long-chain α-hydroxy fatty acid cholesteryl and the like α-or β-Hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosin; creatin; ceramides, spingosins; caffeine, xanthin and its derivatives; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloids, fullerene and other antioxidant / active oxygen scavengers; catechins; kelcetin and other flavones; isoflavones; Polyphenols such as anthocyanidin, chlorogenic acid, apple polyphenol; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; Gyogaol, gingerol; fragrance substances such as menthol, camphor, sedrol and its derivatives; capsaicin, vanillin and the like and derivatives; insect repellents such as diethyl toluamide; complexes of physiologically active substances and cyclodextrins are preferred. Can be mentioned.

Plant / animal / microbial extracts include iris extract, asitaba extract, asnalo extract, asparagus extract, avocado extract, flaxseed extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract. , Inchkou extract, Uikyo extract, Ukon extract, Woolong tea extract, Uwaurushi extract, Agetsu extract, Echinashi leaf extract, Enmeisou extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otaneninjin extract, Otogirisou extract, Odorikosou extract, Ononis extract , Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cucumber extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomogi Extract, crow wheat extract, karukade extract, kanzo extract, oil-soluble kanzo extract, kiwi extract, kiou extract, kikurage extract, kina extract, cucumber extract, kiri leaf extract, guanosine, guava extract, kujin extract, kuchinashi extract, kumazasa extract, clara extract, walnut Extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, quail extract, gentiana extract, gennoshoco extract, tea extract, yeast extract, koboku extract, coffee extract, gobo extract, rice extract, rice Fermented extract, fermented rice bran extract, rice germ oil, confree extract, collagen, kokemomo extract, saishin extract, psycho extract, saitai extract, saffron extract, salvia extract, sabonsou extract, sasa extract, sanzashi extract, sansha extract, sansho Extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Jatoba extract, Shakuyaku extract, Shokyu extract, Shobu root extract, Shirakaba extract, White chrysanthemum extract, Sugina extract, Stevia extract, Stevia fermented product, Nishikawayanagi extract, Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogirisou extract, Seiyouhakka extract, Sage extract, Zeniaoi extract, Senkyu extract, Senburi extract, Souhakuhi extract, Daiou extract, Die Zu extract, Taisou extract, Thyme extract, Dandelion extract, Local clothing extract, Tea extract, Chouji extract, Chigaya extract, Chinpi extract, Tea tree oil, Jincha extract, Togarashi extract, Touki extract, Tokinsenka extract, Tounin extract, Tohi extract, Dokudami extract, Tomato Extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Hass extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Parietaria extract, Hikiokoshi extract, Bisabolol, Hinoki extract, Bifizus bacterium extract, Biwa extract, Fukitanpopo extract, Fukinotou extract, Bukuryo extract, Butcher bloom extract, Grape extract, Grape seed extract, Propolis, Hechima extract, Benibana extract, Peppermint extract, Bodaiju extract, Button extract, Hop extract, Maikaika extract, Pine extract, Maronie extract , Mizubasho extract, Mukuroji extract, Melissa extract, Mozuku extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yuzu extract, Yuri extract, Yokuinin extract, Yomogi extract, Lavender extract, Green tea extract, Eggshell membrane extract, Apple extract, Louis Boss tea extract , Reishi extract, lettuce extract, lemon extract, lotus extract, lotus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, crackle extract and the like are preferable.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenolsulfonate and the like. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid and the like. Examples of the enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease and the like. Preferred examples of nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and disodium adenosine triphosphate.

As fragrances, acetylsedrene, amilcinnamaldehyde, allylamylglycolate, β-ionone, isoe super, isobutylquinoline, iris oil, iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragor, Eugenol, Oak Moss, Opoponax Resinoid, Orange Oil, Eugenol, Oranthiol, Galaxolid, Carbachlor, L-Carbon, Kamfer, Cannon, Carrot Seed Oil, Clove Oil, Methyl Caynate, Geraniol, Geranylnitrile , Isobornyl acetate, Geranyl acetate, Dimethylbenzylcarbyl acetate, Styralyl acetate, Sedrill acetate, Telepinel acetate, pt-butylcyclohexyl acetate, Vetiberyl acetate, benzyl acetate, Linaryl acetate, Isopentyl salicylate, benzyl salicylate, Sandalwood oil, Santa roll, Cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citroneral, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylux Reginoid, Cedarwood Oil, Sedren, Sedrol, Cellory Seed Oil, Thyme Oil, Damascon, Damasenon, Timor, Tuberose Absolute, Decanal, Decalactone, Terpineol, γ-Terpinen, Triplar, Nerol, Nonanar, 2,6-Nonadienor, Nonalactone, Pacholi Alcohol, vanilla absolute, vanillin, basil oil, patcholi oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil, vetiverol , Peppermint oil, pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, millresinoid, muskketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menton, eucalyptus oil, β-yonon, lime oil , Lavender oil, D-limonen, linalol, lylar, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, synthetic fragrances such as various essential oils and natural Fragrances and various blended fragrances are preferred.

Dyes / colorants / dyes / pigments include brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, and blue 204. , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213. , Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1. , Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505. , Red 506, Orange 201, Orange 203, Orange 204, Orange 205, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202-1 , Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow Legal dyes such as No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p- phenylenediamine, HC Blue 2, Basic Blue 26 and other nitro dyes; Disperse dyes; Titanium dioxide, Zinc oxide Inorganic white pigments such as; Inorganic red pigments such as iron oxide (Bengala) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and ocher; Black iron oxide, low Inorganic black pigments such as secondary titanium oxide; Inorganic purple pigments such as mango violet and cobalt violet; Inorganic green pigments such as dye, chromium hydroxide, cobalt titanate; inorganic blue pigments such as ultramarine and navy blue; titanium oxide coated mica, titanium oxide coated oxybismus chloride, titanium oxide coated talc, colored titanium oxide coated mica, oxy Pearl pigments such as bismuth chloride and fish scale foil; metal powder pigments such as aluminum powder, copper powder and gold; surface-treated inorganic and metal powder pigments; red 201, red 202, red 204, red 205, red 220 , Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404, Red 3, Red 104, Red 106, Red 227, Red Organic pigments such as zirconium, barium or aluminum lakes such as 230, red 401, red 505, orange 205, yellow 4, yellow 5, yellow 202, yellow 203, green 3 and blue 1. Surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsantine, chalcone, calsamine, quercetin, closin, chlorophyll, curcumin, cochineal, ciconin and other naphthoquinones, bixins, flavones, beta Natural pigments and dyes such as sianidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5- Oxidation dye intermediates and couplers such as amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and salts thereof; automatic oxidation dyes such as indolin; dihydroxyacetones are preferred.

As the water, in addition to normal water and purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionized water, electrolytically acidic ionized water, ionized water, and cluster water are preferable.

In addition to these, cosmetic raw material standards, compounding ingredient standards by cosmetic type, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), non-pharmaceutical raw material standards, Japanese Pharmacy, pharmaceutical additives Ingredients described in standards, official food additives, etc., and Japanese and foreign patent gazettes and patent publication gazettes (including published gazettes and republished gazettes) whose international patent classification IPC belongs to the A61K7 and A61K8 classifications. It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the described ingredients, in known combinations, blending ratios, and blending amounts.

Examples of the type of cosmetic containing the cosmetic composition of the present invention include hair cosmetics, basic cosmetics, make-up cosmetics, aromatic cosmetics, body cosmetics, skin external preparations such as ointments, and the like. .. From the viewpoint of exerting the effect of the present invention, it can be particularly preferably used for hair cosmetics and basic cosmetics. The cosmetic of the present invention can be produced according to a usual method.

The types of cosmetics containing the cosmetic composition of the present invention will be described in more detail. As hair cosmetics, oil shampoo, cream shampoo, conditioning shampoo, indulgence shampoo, hair color shampoo, and rinse-integrated type Shampoos such as shampoos; rinses, treatments, hair packs, hair foams, hair mousses, hair sprays, hair mists, hair waxes, hair gels, water greases, set lotions, color lotions, hair tonics, hair liquids, pomades, tics, hair creams, hair blows. , Split hair coat, hair oil, permanent wave agent, straight perm agent, oxidative hair dye, hair bleach, hair color pretreatment, hair color after treatment, perma pretreatment, perma after treatment, hair manicure, hair restorer are preferred It is mentioned as.

Basic cosmetics include softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisturizer, moisturizer. -Emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sun screen, make-up lotion, horny smoother, elbow lotion, hand lotion, body lotion and other emulsions; emollient cream, nutrition cream, Nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, make-up cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening Creams such as creams; Gels such as moisture gels; Essences such as moisturizing essences, whitening essences, and UV protection essences; Lipstick cosmetics such as liposome beauty liquids and liposome cosmetics; Peel-off packs, powder packs, washing packs, oil packs, cleansing Packs and masks such as masks; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, washing powder, facial cleansing powder, etc.; cosmetic soap, transparent soap, medicated soap, liquid soap, Soaps such as shaving soaps and synthetic cosmetic soaps are preferred.

Preferred makeup cosmetics include white powder / dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment. ..

Preferable fragrance cosmetics include perfumes, perfumes, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powders, perfume soaps, body lotions and bath oils.

Body cosmetics include body cleaners such as body shampoo, deodorant lotions, deodorant powders, deodorant sprays, deodorant cosmetics such as deodorant sticks, depigmenting agents, depilatory / depilatory agents, bathing agents, insect repellent sprays, etc. Repellers are preferred.

Further, as the external skin preparation, it can be used in a dosage form such as an ointment, a patch, a lotion, a liniment, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

Examples of the dosage form of the cosmetic or skin external preparation containing the cosmetic composition of the present invention include oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, and O /. W / O type and other emulsified cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, Formulation types such as gel-like cosmetics, paste-like cosmetics, emulsified polymer-type cosmetics, sheet-like cosmetics, mist-like cosmetics, and spray-type cosmetics are preferable.

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

(Preparation of cosmetic composition)
The cosmetic composition of the present invention was prepared with the composition shown in Table 1 (Examples 1 to 5). In addition, a composition outside the range of the cosmetic composition of the present invention was prepared with the composition shown in Table 2 (Comparative Examples 1 to 6).

(Stability of cosmetic composition over time)
The cosmetic composition obtained above was stored at 25 ° C. for 1 week, and a change in appearance was confirmed. The evaluation was performed in the following three stages, and the results are shown in Tables 1 and 2. From the results shown in Tables 1 and 2, the cosmetic composition of the present invention was excellent in stability over time. On the other hand, the one using lecithin having a low PC content (Comparative Example 5) and the one using the contents of (A) and (B) exceeding 30% (Comparative Example 6) are not sufficiently dissolved in the component (C). Therefore, the stability over time was insufficient.

〇 No change in appearance from the initial stage △ The appearance changed slightly from the initial stage × The appearance changed significantly from the initial stage

(Preparation of vesicle-containing lotion 1)
While stirring 99 g of purified water at 300 rpm of Stirrer, 1 g of each of the cosmetic compositions of Examples 1 to 5 and Comparative Examples 1 to 6 was slowly added to purified water and stirred at room temperature for 5 minutes to obtain a MEL-containing vesicle. The formed lotion was prepared. The appearance, stability over time, and particle size of the obtained lotion were evaluated by the following methods, and the results are shown in Table 3.

<Appearance>
The appearance of the obtained vesicle-containing lotion was evaluated in the following three stages.

〇 Transparent to slightly turbid △ Slightly turbid × Slightly turbid

<Stability over time>
The obtained vesicle-containing lotion was stored at room temperature for 1 month, and the appearance was evaluated in the following 3 stages.

〇 No change in appearance from the initial stage △ The appearance has changed slightly from the initial stage × The appearance has changed significantly from the initial stage

<Particle size>
The particle size was confirmed by electron microscope observation (TEM image), and the particle size was evaluated in the following two stages.

〇 Observed particle size is less than 100 nm × Observed particle size is larger than 100 nm

As an example, FIG. 1 shows a TEM image of the vesicle obtained with the cosmetic composition of Example 2. As can be seen from FIG. 1, it was confirmed that the particle size was smaller than 100 nm and that a vesicle structure was formed.

From the results in Table 3, a cosmetic composition having a weight ratio of components (A): (B) of 9: 1 to 6: 4 and a content of (A) and (B) of 30% or less was used. The cosmetic waters (Examples 1 to 5) thus obtained were good in appearance, stability, and particle size. On the other hand, the cosmetic waters (Comparative Examples 1 to 3 and 6) using the cosmetic composition outside the range could not be said to have sufficient evaluation. In addition, good results were not obtained even in the case of using lecithin having a PC content of 97.2% and 25.2% (Comparative Examples 4 and 5).

(Preparation of vesicle-containing lotion 2)
5 g each of the polyhydric alcohols shown in Table 4 and 1 g of the cosmetic composition of Example 2 were mixed and heated to 60 ° C. (Part A). Put 94 g of purified water heated to about 60 ° C. in a separate container, slowly add part A while stirring at 300 rpm of the stirrer, stir for 5 minutes, and allow to cool to room temperature to form a cosmetic solution containing MEL-containing vesicles. Was produced. The obtained lotion was evaluated for stability over time by measuring the transmittance at a wavelength of 600 nm and the following method, and the results are shown in Table 4.

<Stability over time>
The obtained vesicle-containing lotion was stored at 50 ° C. for 2 weeks, and the appearance was evaluated in the following three stages.

〇 No change in appearance from the initial stage △ The appearance has changed slightly from the initial stage × The appearance has changed significantly from the initial stage

(Preparation of vesicle-containing lotion 3)
5 g each of the polyhydric alcohols shown in Table 5 and 1 g of the cosmetic composition of Example 2 were mixed and heated to 60 ° C. (Part A). Put 94 g of purified water heated to about 60 ° C. and 2.5 g of a 2% xanthan gum aqueous solution in a separate container, slowly add part A while stirring at a stirrer 300 rpm, stir for 5 minutes, allow to cool to room temperature, and MEL. A lotion containing the contained vesicles was prepared. The transmittance of the obtained lotion was measured at a wavelength of 600 nm, and the results are shown in Table 5.

From the results in Tables 4 and 5, it was found that the cosmetic water containing the cosmetic composition of the present invention has high permeability and excellent transparency. Further, the cosmetic water containing the polyhydric alcohol in addition to the cosmetic composition of the present invention has higher permeability than the product not containing the polyhydric alcohol, and the transparency and the stability over time can be improved. Do you get it.

Example 20 Whitening Toner A toner having the following formulation was prepared. This lotion has excellent transparency, whitening effect, keeps the skin healthy, and can prevent fine wrinkles due to rough skin and dryness.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic Composition of Example 2 2.0
BG 4.0
Innocitol 0.5
Part B xanthan gum 0.05
BG 3.0
Purified water 20.0
Part C 3-O-ethylascorbic acid (VC ethyl: Nippon Fine Chemical Co., Ltd.) 1.0
Purified water 5.0
Part D White fungus polysaccharide (Tremost-TP: Nippon Fine Chemical Co., Ltd.) 0.01
Glycyrrhizinate 2K 0.05
Ethanol 3.0
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid 0.1
Amount of sodium citrate pH 4.5 Amount of purified water totaling 100 ------------- −−−−−−−
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A was heated to 50 ° C. and slowly added to part B with stirring to prepare a nanovesicle solution. Further, parts C and D mixed in advance were added to obtain a uniform liquid.

Example 21 Whitening Toner A toner having the following formulation was prepared. This lotion has an excellent whitening effect and can prevent fine wrinkles caused by rough skin and dryness.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic Composition of Example 1 3.0
DPG 3.0
Glycerin 1.0
Part B purified water 20.0
Part C tranexamic acid (Nippon Fine Chemical Co., Ltd.) 2.0
Purified water 20.0
Part D Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolue-Aquio: Nippon Fine Chemical Co., Ltd.) 0.5
Niacinamide 0.3
Betaine 1.0
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was mixed and slowly added to part B with stirring to prepare a nanovesicle solution. Further, parts C and D mixed in advance were added to obtain a uniform liquid.

Example 22 Moisturizing Toner A lotion having the following formulation was prepared. This lotion was a highly transparent formulation. In addition, it moisturizes the skin, keeps it fresh by suppressing water evaporation, and prevents fine wrinkles due to rough skin and dryness.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic Composition of Example 5 1.0
Diglycerin 3.0
Hydrolyzed hyaluronic acid 0.01
Arginine 0.05
Part B purified water 20.0
Part C (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10
(Neosolve-AquaS: Nippon Fine Chemical Co., Ltd.) 1.0
Betaine 0.5
Pullulan 0.5
Hyaluronic acid Na 0.01
Hydroxyethyl cellulose 0.03
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was mixed and slowly added to part B with stirring to prepare a nanovesicle solution. Further, it was added to the C portion mixed in advance to obtain a uniform liquid.

Example 23 Moisturizing Toner A lotion having the following formulation was prepared. This lotion has an excellent moisturizing effect, moisturizes the skin, keeps it fresh, and prevents fine wrinkles due to rough skin and dryness. In addition, it was possible to uniformly disperse the oily components (astaxanthin, ubiquinone) without adding a surfactant.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic Composition of Example 3 2.0
Diglycerin 3.0
Astaxanthin 0.01
Ubiquinone 0.05
Part B purified water 20.0
Part C (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10
(Neosolve-AquaS: Nippon Fine Chemical Co., Ltd.) 1.0
PEG / PPG / Polybutylene Glycol-8 / 5/3 Glycerin 0.5
Glucosyl ceramide 0.5
Glucosylrutin 0.01
Polyquaternium-51 0.5
Acetyl Hexapeptide-8 0.001
Hydrolyzed collagen 0.05
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was mixed and part B was slowly added with stirring to prepare a nanovesicle solution. Further, it was added to the C portion mixed in advance to obtain a uniform liquid.

Example 24 Gel Toner A toner having the following formulation was prepared. This lotion has a feeling of penetration into the skin, keeps it moisturized and fresh, and can prevent fine wrinkles due to rough skin and dryness.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Hydrogenated Lecithin, Phytosterols (Phytocompo-PP: Nippon Fine Chemical Co., Ltd.) 1.0
Glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl behenate 0.8
Stearic acid 0.3
PEG-10 Dimethicone 0.4
Part B Cosmetic Composition of Example 1 3.0
Purified water 20.0
Part C Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexyl glycerin 0.2
Poly HEMA Glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Hyaluronic acid Na 0.01
Carbomer 0.06
Hydroxide K 0.05
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was heated to about 70 ° C. and uniformly dispersed. Part C was mixed, stirred well, made uniform, and then heated to about 70 ° C. Part B was stirred with a propeller to prepare a nanovesicle solution. Part C was added to part A, stirred at about 70 ° C. using a homomixer, cooled to about 40 ° C., and the mixed solution of part B was added.

Example 25 Transparent gel A gel having the following formulation was prepared. There was a feeling of penetration into this gel skin. In addition, it is possible to keep the skin moisturized and fresh, and prevent fine wrinkles due to rough skin and dryness.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic composition of Example 2 0.5
Glycerin 3.0
Purified water 30.0
Part B PEG-4000 0.2
Methylgluces-10 1.0
Phenoxyethanol 0.3
Pyridoxine hydrochloride 0.05
Ethylhexyl glycerin 0.2
Hydroxyethyl cellulose 0.05
White fungus polysaccharide (Tremost-TP: Nippon Fine Chemical Co., Ltd.) 0.01
Hydrolyzed collagen 0.01
Amount of purified water totaling 100 parts C
(Dimethyltaurine ammonium acrylate / vinylpyrrolidone) Copolymer 0.05
(Acrylate / Alkyl Acrylate (C10-30)) Cross Polymer 0.15
Arginine 0.25
Purified water 30.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was stirred with a propeller to prepare a nanovesicle solution. Part C was made into a viscous liquid when mixed. Part B was mixed to obtain a uniform liquid. A part and B part were added to C part to make it uniform.

Example 26 Whitening emulsion A emulsion having the following formulation was prepared. This milky lotion has an excellent whitening effect and barrier function improving effect, and can permeate and moisturize the skin, maintain freshness, and prevent fine wrinkles due to rough skin and dryness.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Dimer dilinoleate di (isostearyl / phytosteryl)
(LUSPLAN PI-DA: Nippon Fine Chemical Co., Ltd.) 1.0
Bisdiglyceryl polyacyl adipate-2
(Plandol-DP: Nippon Fine Chemical Co., Ltd.) 1.0
Cetyl ethylcaproate (NS-CIO: Nippon Fine Chemical Co., Ltd.) 10.0
Hydrogenated lecithin, phytosterols, BG, glycerin (Phytocompo-SP: Nippon Fine Chemical Co., Ltd.) 10.0
Phenyltrimethicone 3.0
Myristil Alcohol 2.0
Cetanol 1.0
Part B Stearoxy hydroxypropyl Methyl Cellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Cosmetic Composition of Example 2 1.0
Pentylene Glycol 2.0
Glycerin 3.0
Purified water 20.0
Part D VC Ethyl (Nippon Fine Chemical Co., Ltd.) 1.0
Pentetic acid 5Na 0.1
Citric acid 0.1
Amount of sodium citrate pH 4.5 Purified water 5.0
Part E Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 -------------
(Preparation method)
Parts A and E were each heated to about 70 ° C. and uniformly dissolved. Part B was stirred to obtain a viscous liquid. Part C was mixed to prepare a vesicle solution. At about 70 ° C., part A was added and emulsified while stirring part E with a homodisper. Parts B, C and D were added at about 50 ° C., and the mixture was stirred and uniformly dissolved.

Example 27 Moisturizing Emulsion An emulsion having the following formulation was prepared. The coexistence of two types of particles, A, B, and E, and C, gives a characteristic feeling of use to the skin, moisturizes the skin, keeps it fresh, and makes the skin rough and dry. It is possible to prevent fine wrinkles caused by.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Hydrogenated lysolecithin (LP70H: Nippon Fine Chemical Co., Ltd.) 0.1
Part B Triethylhexanoin (IOTG: Nippon Fine Chemical Co., Ltd.) 3.0
Dimer dilinoleic acid dimer dilinoleil,
Tri (caprylic acid / capric acid) glyceryl (LUSPLAN SR-DM4: Nippon Fine Chemical Co., Ltd.) 0.5
Dimethicone (100CS) 5.0
Hydrogenated polyisobutene 3.5
Setostearyl alcohol 1.0
Arachidyl alcohol 0.1
Jojoba Alcohol 3.0
Kimil alcohol 0.3
Ceraquil Alcohol 0.1
Hexildecanol 0.5
Part C Cosmetic Composition of Example 1 2.0
Purified water 20.0
Part D (Hydroxyethyl Acrylate / Acryloyl Dimethyl Taurine Na) Copolymer 0.2
Snow fungus polysaccharide (Tremost-TP: Nippon Fine Chemical Co., Ltd.) 0.03
Carbomer 0.1
Purified water 30.0
Part E (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, glycerin (Neosolue-QuaaS: Nippon Fine Chemical Co., Ltd.) 0.5
Polyquaternium-51 1.0
Ascorbyl Glucoside 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 -------------
(Preparation method)
Parts A, B, and E were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed with a propeller (room temperature) to prepare a nanovesicle solution. Part D was mixed and stirred to obtain a viscous liquid. After adding the B part while stirring the A part with a homodisper, the E part was added and emulsified. After cooling, parts C and D were added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 28 UV Emulsion A UV emulsion having the following formulation was prepared. This milky lotion had an excellent sun protection effect, and had a light feeling of use without feeling sticky or squeaky.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 5, ceramide 6
(Phytocompo-C5: Nippon Fine Chemical Co., Ltd.) 1.0
Cosmetic Composition of Example 5 1.5
Part B Diethylpentanediol dineopentane (Neosolue-DE: Nippon Fine Chemical Co., Ltd.) 5.0
Methylpentanediol dineopolynate (Neosolue-MP: Nippon Fine Chemical Co., Ltd.) 2.0
Isodecyl neopentane (DUB VCI-10: Nippon Fine Chemical Co., Ltd.) 2.0
Plandol-ISS (Nippon Fine Chemical Co., Ltd.) 0.8
Dimethicone 5.0
Ethylhexyl methoxycinnamate 5.0
Dimethoxybenzylidene dioxoimidazolidine propionate ethylhexyl 0.5
t-Butylmethoxydibenzoylmethane 0.5
Cinoxate 1.0
Dihydroxydimethoxybenzophenone 0.5
Tetra hydroxybenzophenone 0.1
Methylbis trimethoxycinnamate (trimethylsiloxy)
Cyril isopentyl 0.5
2-Ethylhexyl Paradimethylaminobenzoate 1.0
Bisethylhexyloxyphenol methoxyphenyl triazine 1.0
Diethylaminohydroxybenzoyl hexyl benzoate 1.0
Ethylhexyl triazone 1.0
3- (4'-Methylbenzylidene) -d, l-camphor 1.0
Methyl 2,5-diisopropylcinnamate 1.0
Octyl salicylate 2.0
Homomentyl salicylate 1.5
1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione 1.0
Amyl paradimethylaminobenzoate 0.5
Polyglyceryl pentastearate-10 1.0
N-lauroyl sarcosine isopropyl 2.0
Isostearyl alcohol 1.0
Stearyl alcohol 0.5
2-Octyldodecanol 1.0
Dimerdiol 0.5
Benzyl alcohol 0.5
Isostearic acid 1.0
Behenic acid 0.5
Undecylenic acid 0.2
12-Hydroxystearic acid 0.2
Palmitooleic acid 0.1
Oleic acid 0.7
Linoleic acid 0.2
Linolenic acid 0.01
Erucic acid 1.0
Rice wax 0.1
Celesin 0.1
Paraffin wax 0.1
Microcrystalline wax 0.1
Polyethylene 0.1
Safflower oil 0.5
Olive oil 0.5
Castor oil 0.3
Avocado oil 0.3
Sesame oil 0.3
Tea oil 0.3
Evening primrose oil 0.3
Wheat germ oil 0.3
Part C Hydroxyethyl Cellulose 0.2
Stearoxy hydroxypropyl Methyl Cellulose 0.8
Snow fungus polysaccharide (Tremost-TP: Nippon Fine Chemical Co., Ltd.) 0.03
Purified water 20.0
Part D Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.5
3-O-Ethyl Ascorbic Acid (Nippon Fine Chemical Co., Ltd .; VC Ethyl) 0.5
Arbutin (Nippon Fine Chemical Co., Ltd.) 0.5
Phenoxyethanol 0.2
Methylparaben 0.15
Sodium dihydroxydimethoxybenzophenone disulfonate 0.5
Phenylbenzimidazole sulfonic acid 1.0
Na hydroxide 1.0
Amount of purified water totaling 100 -------------
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to obtain a viscous liquid. After adding the B part while stirring the A part with a homomixer, the D part was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 29 UV emulsion A UV emulsion having the following formulation was prepared. This milky lotion has a characteristic feeling of use and excellent sunburn prevention effect by coexisting two kinds of particles consisting of particles A, B and E and parts D, and there is no stickiness or squeak. It was moist.
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Part B Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 1.0
Dimethicone 10.0
Ethylhexyl methoxycinnamate 7.0
t-Butylmethoxydibenzoylmethane 1.5
Bisethylhexyloxyphenol methoxyphenyl triazine 1.0
Diethylaminohydroxybenzoyl hexyl benzoate 0.5
Ethylhexyl triazone 1.0
Homo salate 0.5
4- (2-β-Glucopyranosiloxane) propoxy-2-hydroxybenzophenone 0.7
2-Hydroxy-4-methoxybenzophenone 0.3
Dimethyldiethylbenzalmalonate 0.5
Part C Hydroxyethyl Cellulose 0.2
Stearoxy hydroxypropyl Methyl Cellulose 0.8
Snow fungus polysaccharide (Tremost-TP: Nippon Fine Chemical Co., Ltd.) 0.03
Purified water 20.0
Part D Cosmetic composition of Example 3 1.0
Purified water 15.0
Part E Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.5
VC Ethyl (Nippon Fine Chemical Co., Ltd.) 1.0
Tranexamic acid 1.0
Glyceryl ascorbic acid 0.5
Arbutin 0.5
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 Part F Titanium oxide (silica treatment) 1.0
Zinc oxide (silica treatment) 2.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Parts A, B, and E were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to obtain a viscous liquid. Part D was mixed by stirring with a propeller to obtain a nanovesicle liquid. After adding the B part while stirring the A part with a homodisper, the E part was added and emulsified. After cooling, parts D and F were added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 30 Skin care cream A cream having the following formulation was prepared. This cream moisturizes the skin, keeps it fresh, and prevents fine wrinkles caused by rough skin and dryness.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 1.0
Jojoba oil 2.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-MCT (Nippon Fine Chemical Co., Ltd.) 5.0
LUSPLAN DD-DHR (Nippon Fine Chemical Co., Ltd.) 3.0
Propylene glycol monostearate 0.6
Behenyl alcohol 2.0
Ethylparaben 0.1
Liquid isoparaffin 0.5
Carnauba wax 0.3
Corn oil 0.3
Rapeseed oil 1.0
Sunflower oil 1.0
Wheat germ oil 1.0
Flaxseed oil 0.1
Cottonseed oil 0.1
Soybean oil 0.1
Cholesteryl nonanoate 0.1
Cholesteryl stearate 0.1
Cholesteryl isostearate 1.0
Cholesteryl oleate 0.1
Cholesteryl 12-hydroxystearate 0.1
Long-chain branched fatty acid cholesteryl 0.3
Octyldodecyl myristic acid 1.0
Dimer dilinoleic acid hardened castor oil 1.0
Hydroxyalkyl dimer dilinoleyl ether 1.0
Phenyltrimethicone 1.0
Diphenyldimethicone 1.0
Methylhydrogenpolysiloxane 1.0
Polyglyceryl-3 polydimethylsiloxyethyl dimethicone 0.5
Polyoxyethylene / methylpolysiloxane copolymer 1.0
Tannin 0.01
Sesamin 0.01
Proanthocyanidins 0.01
Gravlydin 0.01
Grablen 0.01
Liquiritin 0.01
Isoliquilithin 0.01
Lactoferrin 0.01
Shogaol 0.01
Gingerol 0.01
Part B (acryloyldimethyltaurine /
Behennes Methacrylic Acid-25) Copolymer 0.2
(Acryloyl dimethyl taurine ammonium / VP) copolymer Purified water 20.0
Part C Cosmetic composition of Example 4 0.5
Hydrogenated lecithin, cholesterol (Composite-PC: Nippon Fine Chemical Co., Ltd.) 1.5
Lysolecithin 0.05
Hydrogenated egg yolk lecithin 0.1
Stigmasterol 1.0
Stannole 1.0
Dihydrocholesterol 0.1
Lanosterol 0.1
Dihydrolanosterol 0.1
Glycerin 7.0
DPG 7.0
Menthol 0.1
Camphor 0.1
Tocopherol ferulate 0.1
Tocopherol Phosphate Ester 0.1
Polyglyceryl laurate-10 0.5
Tocotrienols 0.1
Part D Citric acid 0.07
Appropriate amount of Na citrate EDTA-2Na 0.1
Tranexamic acid 2.0
Methylparaben 0.1
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to uniformly dissolve. Part B was mixed and stirred to obtain a viscous liquid. Part C was mixed, heated to about 70 ° C., and uniformly dispersed. Part D was mixed and heated to about 70 ° C. to uniformly dissolve. After adding the A part to the C part while stirring with a homogenizer, the D part was added and emulsified. After cooling, part B was added at about 50 ° C., and the mixture was stirred and uniformly dissolved.

Example 31 Skin care cream A cream having the following formulation was prepared. This cream improves the feeling of use by two kinds of particles consisting of A and C parts and D part, softens the skin, and the skin after use is non-greasy and moist, and these effects last for a long time. ..

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-Aquio (Nippon Fine Chemical Co., Ltd.) 1.5
Neosolue-EHS (Nippon Fine Chemical Co., Ltd.) 8.0
Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 1.0
Diisopropyl sebacate (IPSE: Nippon Fine Chemical Co., Ltd.) 2.0
Bacil isostearate 2.0
Shea butter 3.0
Cyclopentasiloxane 5.0
Isostearyl pivalate 0.1
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical Co., Ltd.) 0.1
Ethylparaben 0.2
Stearyl alcohol 3.5
Dimethicone 1.0
Cyclomethicone 3.0
Tocopherol 0.1
Ascorbyl Tetrahexyl Decanoate 3.0
Tocopheryl Phosphyl Ascorbyl 2.0
Placenta extract 1.0
Oryzanol 0.3
Phytosphingosine 0.0001
Ubiquinone 0.03
Carotene 0.05
Lycopene 0.01
Astaxanthin 0.01
Lutein 0.01
Peanut oil 0.1
Rice bran oil 1.0
Hydrogenated castor oil 0.3
Jojoba oil 2.0
Orange roughy oil 1.0
Liquid lanolin (liquid lanolin: Nippon Fine Chemical Co., Ltd.) 1.0
Lanolin (Purified Lanolin: Nippon Fine Chemical Co., Ltd.) 1.0
Polyoxyethylene lanolin 1.0
Lanolin Alcohol A (Nippon Fine Chemical Co., Ltd.) 0.3
Lanolin acetate alcohol 0.1
Cholesteryl acetate 0.1
Polyglyceryl triisostearate-2 1.0
PEG-60 glyceryl isostearate 1.5
Stearic acid PG (SE) 1.0
Glyceryl stearate (SE) 1.0
Octocrylene 0.05
Part B Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.05
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
2-methacryloyloxyethyl phosphorylcholine
Butyl methacrylate copolymer solution 0.05
(HEMA Glucoside / Ethyltrimonium Methacrylate Trimonium Chloride) Copolymer (20%, Nippon Fine Chemical Co., Ltd.) 0.4
Glutathione 0.3
4- (4-Hydroxyphenyl) -2-butanol 1.5
Butyl resorcinol 1.5
Arbutin (Nippon Fine Chemical Co., Ltd.) 3.0
Ascorbyl Phosphate Mg 1.0
Part C BG 5.0
Glycerin 7.0
DPG 2.0
Sodium metabisulfite 0.1
Imidazolenium urea 0.1
Polyvinylpyrrolidone 0.1
Pullulan 0.1
Polyvinyl alcohol 0.1
Dehydroacetic acid 0.1
PEG-30 1.0
Diglycerin 1.0
Polyglycerin 1.0
Pentetic acid 5Na 0.05
Appropriate amount of phosphoric acid and Na phosphate Amount of purified water totaling 100 Part D Cosmetic composition of Example 2 1.0
Purified water 15.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was heated to about 70 ° C. and uniformly dissolved. Part C was heated to about 70 ° C. and dispersed. Part D was stirred well with a propeller to prepare a nanovesicle solution. While stirring with a homomixer at about 70 ° C., part A was gradually added to part C, emulsified and then mixed uniformly, cooled to about 40 ° C., parts B and D were added, and the mixture was uniformly mixed.

Example 32 Skin care cream A cream having the following formulation was prepared. This cream has a characteristic feeling of use due to the coexistence of particles consisting of parts A, B and C and two types of particles consisting of parts D, softening the skin and making the skin moist and non-greasy after use. These effects last for a long time.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 5.0
PG 2.0
Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6II
(Phytocompo-C: Nippon Fine Chemical Co., Ltd.) 1.0
Part B Di (phytosteryl / octyldodecyl) lauroyl glutamate
(Plandol-LG2: Nippon Fine Chemical Co., Ltd.) 0.5
Plandol-LG1 (Nippon Fine Chemical Co., Ltd.) 0.5
Dimari Linoleic Acid Dimari Linole (LUSPLAN DD-DA7: Nippon Fine Chemical Co., Ltd.) 0.1
Plandol-MAS (Nippon Fine Chemical Co., Ltd.) 0.5
Glyceryl amide ethyl methacrylate
Stearyl Methacrylate Copolymer 0.05
Olive oil 3.5
Macademia nut oil 4.5
Hydrogenated vegetable oil 3.0
Dimethicone (100cs) 0.5
Ethylhexyl methoxycinnamate 2.0
Ethylparaben 0.15
Lanolin fatty acid octyldodecyl 1.0
Isostearic acid hardened castor oil 0.5
Ethyl oleate 3.0
Avocado Oil Fatty Acid Ethyl 2.0
Isopropyl palmitate 2.0
Isopropyl isostearate 1.0
Methyl heptyl laurate 3.0
Methylheptyl myristate 3.0
Methyl heptyl palmitate 3.0
Methyl heptyl isostearate 3.0
Diethyl sebacate 1.0
Diisopropyl sebacate 1.0
Diisopropyl adipate 1.0
Diisobutyl adipate 1.0
Dioctyl succinate 1.0
Triethyl citrate 1.0
Ethyl lactate 1.0
Diisostearyl malate 5.0
γ-docosalactone 0.2
Glyceryl trioleinate 0.1
Glyceryl triisostearate 0.1
Glyceryl diisostearate 0.1
Birds (caprylic acid / capric acid / myristic acid /
Stearic acid) glyceryl 0.1
(Behenic acid / icosane diacid) Glyceryl 0.1
Trimethylolpropane trioctanoate 0.5
Neopentyl glycol dicaprate 1.0
Perfluorodecane 1.0
Perfluorooctane 1.0
5,5'-Dipropyl-biphenyl-2,2'-diol 0.3
Oil-soluble chamomile extract 0.3
Oil-soluble licorice extract 0.05
Retinol 0.1
Retinyl acetate 0.1
Retinyl palmitate 0.1
Pyridoxine dioctanoate 0.1
Pyridoxine dipalmitate 0.1
Tocopherol nicotinate 0.1
Tocopherol acetate 0.1
Tocopherol linoleate 0.1
Glycyrrhetinic acid 0.05
Hinokitiol 0.05
Indomethacin 0.05
Hydrocortisone acetate 0.1
Prednisone 0.1
Diphedramin hydrochloride 0.1
Borneol 0.1
Cepharanthine 0.001
Photosensitizer 301 0.001
Photosensitizer 401 0.001
Cetyl tranexamic acid 2.0 2.0
Part C Cosmetic composition of Example 2 2.5
Ascorbyl Tetrahexyl Decanoate 1.0
Purified water 10.0
Part D Methylparaben 0.1
Phenoxyethanol 0.2
Xanthan gum 0.1
(Acrylate / Alkyl Acrylate (C10-30)) Cross Polymer 0.2
(Hydroxyethyl acrylate /
Acryloyl dimethyl taurine Na) copolymer 0.2
Arginine 0.3
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was heated to about 70 ° C. and uniformly dispersed. Part B was heated to about 80 ° C. and uniformly dissolved. Part C was stirred well to prepare a nanovesicle solution. While stirring part A with a homodisper, part B was added and dispersed (part E). Further, the D part was added to the E part while stirring. The mixture was stirred and cooled to about 40 ° C.

Example 33 Skull lotion A scalp lotion having the following formulation was prepared. This lotion can soften the scalp and improve the stickiness and dryness of the scalp.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 4.0
Pentylene Glycol 2.0
Maltitol liquid 0.5
Glycyrrhetinic acid 0.05
PPG-5 Phytosterol 0.1
The cosmetic composition of Example 2 2.5
Part B Methylparaben 0.1
Purified water 50.0
Part C ethanol 10.0
Neosolue-Aquio (Nippon Fine Chemical Co., Ltd.) 1.0
Tocopherol acetate 0.05
Menthol 0.1
Mentoxipropanediol 0.05
Betaine 0.2
Carrot extract 0.1
Swertia japonica extract 0.1
Menispermaceae root extract 0.003
Pyridoxine hydrochloride 0.05
Panthenol 0.1
PCA-Na 0.1
Amount of purified water totaling 100 -------------
(Preparation method)
Each component was measured and mixed uniformly. Part A was added to part B to prepare a nanovesicle solution. Further, part C was added while stirring to make it uniform.

Example 34 Skull lotion A scalp lotion having the following formulation was prepared. This lotion has excellent moisturizing and penetrating sensations, improves the condition of the scalp, and can suppress stickiness and dryness.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 2.0
The cosmetic composition of Example 5 0.3
Purified water 10.0
Part B Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.5
Nicotinamide 1.0
Dipotassium glycyrrhizinate 0.1
VC Ethyl (Nippon Fine Chemical Co., Ltd.) 0.3
Hyaluronic acid Na 0.01
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 0.5
Caprilyl Proline 0.3
Raffinose 0.2
Arginine 0.5
Serine 0.1
Glycine 0.1
Purified water 50.0
Part C ethanol 10.0
Methylparaben 0.1
Menthol 0.1
Mentoxipropanediol 0.1
Ethyl dicarboethoxypantothenate 0.2 0.2
Camphor 0.1
Carrot extract 1.0
Swertia japonica extract 1.0
Glycosyl trehalose 0.5
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was stirred with a propeller to prepare a nanovesicle solution. Each component of part B and part C was measured and mixed uniformly. After adding the B part to the A part to make it uniform, the C part was added to make it uniform.

Example 35 Body shampoo A body shampoo with the following formulation was prepared. This body shampoo foamed well, was moisturized after washing, and gave a soft feeling to the skin.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic composition of Example 2 0.3
Purified water 10.0
Part B Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.5
Cocoyl Methyl Taurine Na 10.0
Lauroyl hydrolyzed silk Na 6.0
Lauroylmethylalanine Na 10.0
Sodium cocoamphoacetate (30%) 4.0
Cocamidopropyl Betaine (30%) 10.0
Olefin (C14-16) Na Sulfonate 5.0
Polyquaternium-10 1.3
Guar hydroxypropyltrimonium chloride 0.8
Acetyl hyaluronic acid Na 0.02
Cocamide DEA 3.0
Glycerin 5.0
Methylparaben 0.2
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was stirred and mixed with a propeller to prepare a nanovesicle solution. Part B was weighed, heated to about 80 ° C., and mixed uniformly. Part B was cooled with stirring, and part A was added at 40 ° C.

Example 36 Shampoo A shampoo with the following formulation was prepared. This shampoo foams well, moisturizes the hair, and can be used for damage care.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic composition of Example 1 0.5
Purified water 10.0
Part B Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.03
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 0.1
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 0.5
Laureth-4 Carboxylic Acid Na (28%) 10.0
Laureth-6 Carboxylic Acid 4.0
Cocamidopropyl Betaine (30%) 10.0
Lauroylmethylalanine Na (30%) 5.0
Cocamidomethyl MEA 3.0
Coconut oil fatty acid PEG-7 glyceryl 5.0
Na hydroxide 1% solution 0.5
Polyquaternium-10 0.6
Cationized guar gum 0.2
Polyquaternium-7 0.5
EDTA-2Na 0.05
Methylparaben 0.2
Phenoxyethanol 0.4
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was stirred with a propeller to prepare a nanovesicle solution. Part B was weighed, heated at about 80 ° C., and uniformly stirred and mixed. Part B was cooled and part A was added at 40 ° C.

Example 37 Non-rinse hair treatment A non-rinse hair treatment according to the following formulation was prepared. This hair treatment improved the damage inside the hair and was able to give a moist and smooth feeling without using silicone.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic Composition of Example 1 1.0
Purified water 10.0
Part B Polyquaternium-37 2.0
Squalene 2.0
PPG-3 Caprylyl Ether 2.0
Microcrystalline wax 0.1
Lanolin alcohol 0.2
Montan wax 0.1
Polyethylene wax 0.1
Beeswax 0.1
Japan wax 0.2
Celesin 0.1
Dicapric acid PG 1.0
Almond oil 0.5
Ethylhexyl ethylhexanoate 1.0
Candelilla wax extract 0.1
Octyldodecyl erucate 4.5
Tocopherol acetate 0.02
γ-docosalactone, tri (caprylic acid / capric acid) glyceryl (Elcalactone MCT: Nippon Fine Chemical Co., Ltd.) 2.0
Dipentaerythrityl tripolyhydroxystearate 1.5
Broccoli seed oil 0.3
Sphinganin 0.01
PPG-5 Phytosteryl 0.5
Glycerin 4.0
Sorbitol 2.0
Phenoxyethanol 0.5
Part C Hydrolyzed Conchiolin 0.1
Panthenol 0.1
Hydroxypropyltrimonium hyaluronate 0.01
Polyquaternium-11 0.2 0.2
Glycosyl trehalose 0.1
Glyceryl glucoside 0.3
Arginine 0.1
Purified water 10.0
Part D Purified water Amount totaling 100 Hydroxypropyl starch phosphate 1.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part D was uniformly dispersed and heated to about 80 ° C. Next, the B part was heated to about 80 ° C. and dissolved. Part A was stirred with a propeller to prepare a nanovesicle solution. Part B was added to part D with stirring, mixed uniformly, and then cooled to about 40 ° C. Parts A and C were added and mixed uniformly.

Example 38 Non-rinse scalp / hair treatment A non-rinse scalp / hair treatment according to the following formulation was prepared. This hair treatment improved the damage to the hair and improved the smoothness and moistness. In addition, the scalp environment can be improved.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic composition of Example 3 0.5
Purified water 10.0
Part B Neosolue-Aquio (Nippon Fine Chemical Co., Ltd.) 2.0
Ethanol 40.0
Glycyrrhetinic acid 0.02
PPG-3 Caprylyl Ether 0.3
γ-Docosalactone, diethyl sebacate (Elcalactone DES: Nippon Fine Chemical Co., Ltd.) 1.5
PEG / PPG-20 / 20 Dimethicone 0.2
PEG-12 Dimethicone 0.4
Hydrogenated retinol 0.1
Trishexyldecanoic acid pyridoxine 0.05
Bisglyceryl ascorbic acid 0.3
Hexil 3-glyceryl ascorbic acid 0.3
Part C Triethanolamine 0.1
Amount of purified water totaling 100 Acrylate / Alkyl acrylate (C10-30)) Crosspolymer 0.4
Carbomer 0.05
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Acryloyl dimethyl taurine ammonium / VP) copolymer 0.05
(Acryloyldimethyltaurine ammonium / Behenez methacrylic acid-25) Crosspolymer 0.1
Hydroxypropyl chitosan 0.1
Methylparaben 0.1
Phenoxyethanol 0.2
Part D VC Ethyl (Nippon Fine Chemical Co., Ltd.) 0.05
Nicotinamide 0.3
Pyridoxine hydrochloride 0.1
Caffeine 0.1
Glucosyltrehalose 0.1
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Parts B and D were heated to about 50 ° C. and dissolved. Part A was mixed with stirring with a propeller to prepare a nanovesicle solution. Next, the C part was uniformly dispersed to obtain a viscous liquid. Part C was added in the order of parts A, B, and D while stirring, and the mixture was uniformly mixed.

Example 39 Hair Treatment A treatment with the following formulation was prepared. This treatment was a treatment that could improve hair damage without using silicone and give a moist feeling, smoothness, smooth feeling and its lasting feeling.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic Composition of Example 4 2.0
Purified water 10.0
Part B Neosolue-Aquio (Nippon Fine Chemical Co., Ltd.) 0.2
Dimer dilinoleic acid Dimer dilinoleil, tri (caprylic acid / capric acid) glyceryl (LUSPLAN SR-DM4: Nippon Fine Chemical Co., Ltd.) 0.1
Candelilla wax 0.2
Cetyl Esters 0.3
Stearyl Ethylhexanoate 1.0
Cetearyl alcohol 3.5
PEG-200 0.5
Hydroxyethyl cellulose 0.4
Setrimonium chloride (30%) 1.0
Behentrimonium chloride (80%) 1.0
Trideces-6 0.3
BHT 0.03
Part C Methylparaben 0.2
Citric acid 0.05
Amount of purified water totaling 100 Part D PPG-3 millistil 0.5
DUB VIC-10 (Nippon Fine Chemical Co., Ltd.) 1.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Parts B and C were heated to about 80 ° C. and dissolved. Part A was mixed with stirring with a propeller to prepare a nanovesicle solution. Part C was gradually added to part B and mixed uniformly. Part D was added with stirring at about 50 ° C. to make it uniform.

Example 40 Hair Treatment A treatment with the following formulation was prepared. This treatment is a complex of white fungus polysaccharide and behenamide propyldimethylamine that can be easily applied to the hair to give volume, and the composition of the example can penetrate into the hair for damage care. there were.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic composition of Example 1 0.3
Purified water 10.0
Part B Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.5
Propane Glycol 3.0
Behenamide propyldimethylamine 1.5
Cetanol 2.2
Stearyl alcohol 0.8
Hydrogenated rapeseed oil alcohol 0.5
Neopentyl glycol diethylcaproate 0.8 0.8
Jojoba seed oil 1.0
Glyceryl stearate 0.4
Propylparaben 0.1
Cocamide MEA 0.8
Caesarpinia Spinosa hydroxypropyltrimonium chloride 0.1
Rice bran wax 0.5
Glycerin 1.0
Part C Methylparaben 0.1
Lactic acid 0.4
Amount of purified water totaling 100 Part D Shikuki jellyfish polysaccharide aqueous solution (Tremoist-SL: Nippon Fine Chemical Co., Ltd.) 1.0
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Parts B and C were heated to about 80 ° C. and dissolved. Part A was mixed with stirring with a propeller to prepare a nanovesicle solution. Part C was gradually added to part B and mixed uniformly. A part and D part were added with stirring at about 50 ° C. to make them uniform.

Example 41 Harikoshi Treatment A treatment with the following formulation was prepared. This treatment repairs damage from the inside of the hair, gives it a feeling of elasticity, has the effect of increasing volume, and suppresses the fading of colored hair.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic composition of Example 3 0.5
Purified water 10.0
Part B Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 0.3
Cetanol 1.0
Elcalactone DES (Nippon Fine Chemical Co., Ltd.) 2.5
Behentrimonium chloride (80%) 1.0
DPG 0.4
Phenoxyethanol 0.3
Neosolue-EHS (Nippon Fine Chemical Co., Ltd.) 2.0
Part C Hydroxyethyl Cellulose 0.3
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Phenoxyethanol 0.4
EDTA-2Na 0.05
Amount of purified water totaling 100 -------------
(Preparation method)
Part A was mixed with stirring with a propeller to prepare a nanovesicle solution. Part C was heated to about 60 ° C. and dissolved. Next, the B part was heated to about 80 ° C. and dissolved. Part B was added while stirring part C, and after mixing uniformly, the mixture was cooled to about 40 ° C. and part A was added to make it uniform.

Example 42 Rinse Treatment A treatment with the following formulation was prepared. This treatment had a damage care effect inside the hair, gave the hair a moist feel, and gave a volume-up effect.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cosmetic Composition of Example 4 1.5
Purified water 10.0
Part B Sunflower oil fatty acid phytosteryl (Plandol-SUN: Nippon Fine Chemical Co., Ltd.) 3.0
Setrimonium chloride (70%) 1.0
Stearamidopropyldimethylamine 0.5
Stealtrimonium chloride 0.8
Cetyl ethylcaproate (NS-CIO: Nippon Fine Chemical Co., Ltd.) 1.5
Behenyl alcohol 0.3
Hydrogenated rapeseed oil alcohol 0.3
Myristyl alcohol 0.3
LUSPLAN SR-DM4 (Nippon Fine Chemical Co., Ltd.) 0.5
Behendimonium stearyl ethyl phosphate 0.1
Dimethicone (1 million cs) 1.0
Glycerin 1.0
Propane diol 0.3
Part C Purified water Total amount of 100 Malic acid 0.2
Hydroxyethyl cellulose 0.2
Part D Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Parts B and C were heated to about 80 ° C. and dissolved. Part A was mixed with stirring with a propeller to prepare a nanovesicle solution. Part C was gradually added to part B and mixed uniformly. A part and D part were added with stirring at about 50 ° C. to make them uniform.

6 is a TEM image of a vesicle obtained by using the cosmetic composition of Example 2.

Claims (5)

It consists of the following components (A) to (C), the weight ratio of the component (A) to the component (B) is 9: 1 to 6: 4, and the total content of the component (A) and the component (B). Is 2 to 30% by weight, and the content of the component (C) is 70 to 98% by weight.
(A) Mannosyl erythritol lipid having a structure represented by the following general formula (1)

(In the formula, R1 and R2 represent hydrogen or an aliphatic acyl group having 2 to 24 carbon atoms (however, hydrogen is not taken at the same time). In addition, R3 and R4 represent hydrogen or acetyl groups, and R5 represents hydrogen or carbon atoms. Represents 2 to 24 aliphatic acyl groups.)
(B) Hydrogenated lecithin with a phosphatidylcholine content of 40-90% (C) polyhydric alcohol A cosmetic containing the cosmetic composition according to claim 1. A cosmetic composition obtained by dispersing the cosmetic composition according to claim 1 in water, and forming a vesicle with the component (A) and the component (B). Further, claims 1 to 1, which contain an oligomer ester of a linear or branched divalent carboxylic acid having 14 to 22 carbon atoms and a polyglycerin having an average degree of polymerization of 2 to 15 calculated from the hydroxyl value. The cosmetic composition or cosmetic according to any one of 3. The cosmetic composition or cosmetic according to any one of claims 1 to 4, further comprising tocopherol.

Images