JP6832676B2 - Cosmetics - Google Patents

Description

The present invention provides a cosmetic having an excellent moisturizing effect, which contains a monoester of cyclohexanedicarboxylic acid and cholesterol.

It is known that dry skin not only causes rough skin and fine wrinkles, but also triggers itching and inflammation. Preventing dry skin keeps the skin beautiful and healthy, and prevents skin diseases. It is also important as a treatment. It is known that the stratum corneum, which consists of only about 20 μm of the outermost layer of the skin, is greatly involved in the drying of the skin, and it is important to maintain the normal water retention function and skin barrier function of the stratum corneum. Become.

The stratum corneum has a structure in which keratinocytes form a layered structure of 10 to 20 layers, and the gaps between the keratinocytes are filled with intercorneocyte lipids, as compared with the relationship between blocks forming a block wall and mortar. doing. The intercellular lipids in the stratum corneum not only adhere to each other and support the stratum corneum structure, but also play an important role in water retention and barrier function of the stratum corneum. It is considered that the water retention / barrier function of this intercellular lipid is largely related to the structure formed by the intercellular lipid. That is, the intercellular lipids in the stratum corneum are mainly composed of ceramide, cholesterol, and fatty acids, but form a layered structure (lamellar structure) that sandwiches water, and such a lamellar structure holds water and goes to the outside. It is thought that it contributes to the water retention and barrier function of the stratum corneum by controlling the evaporation of water.

Methods for improving the dryness of the skin include a method of suppressing transepidermal water evaporation using an oily component such as petrolatum, and a water-soluble moisturizer such as glycerin, pyrrolidone carboxylate, amino acids, peptides, and hyaluronate. A method using an agent is known, but a method of adding an intercorneocyte lipid component such as ceramide or cholesterol to improve the barrier function of the skin is also generally used. Attempts have also been made to use derivatives and similar substances in place of ceramides and cholesterol, which are highly crystalline and difficult to incorporate into cosmetics. As one of such attempts, a cosmetic containing a monoester of cholesterol and α, ω-dicarboxylic acid or alkenyl succinic acid having a linear hydrocarbon chain having 2 to 10 carbon atoms, which is a cholesterol derivative, is disclosed. (Patent Documents 1 and 2). According to these documents, it is described that the cholesterol monoester of this document is useful as a component of a moisturizing cosmetic that improves the water retention capacity of the stratum corneum. However, these cholesterol monoesters have a drawback that they are easily hydrolyzed, and are not sufficient in terms of stability.

Japanese Unexamined Patent Publication No. 5-213731 Japanese Unexamined Patent Publication No. 7-010731

An object of the present invention is to provide a cosmetic having excellent moisturizing properties and stability by using a cholesterol derivative capable of imparting a moisturizing effect and having excellent stability.

In view of this situation, the present inventors have made extensive studies and found that a cosmetic containing a monoester of cyclohexanedicarboxylic acid and cholesterol can solve the above-mentioned problems, and completed the present invention.

The monoester of cyclohexanedicarboxylic acid and cholesterol of the present invention can be used in cosmetics to impart a moisturizing effect. Further, since the dicarboxylic acid having a ring structure in the molecule is used, the hydrolysis stability is excellent, so that a stable cosmetic can be obtained.

The cosmetic of the present invention is a cosmetic characterized by containing a monoester of cyclohexanedicarboxylic acid and cholesterol.

Cholesterol used in the monoester of the present invention is a kind of organic compound classified into sterols, and is a compound widely distributed in the living body of mammals and fish including humans. Industrially, it can be obtained mainly by extracting and purifying from wool fat. In addition, it can be obtained from the cerebrospinal cord of cattle and pigs, fish oil, cod liver oil of squid, and the like. In the present invention, any origin may be used, and one containing a sterol component other than cholesterol may be used.

The cyclohexanedicarboxylic acid used in the monoester of the present invention includes 1,2-cyclohexanedicarboxylic acid, 1,3-cyclohexanedicarboxylic acid, and 1,4-cyclohexanedicarboxylic acid, depending on the position of the carboxy group attached to the cyclohexane ring. As is known, any of them can be used in the present invention. Further, these may be either a cis form or a trans form, or may be a mixture thereof. Of these, 1,2-cyclohexanedicarboxylic acid can be preferably used in the present invention.

The method for producing the monoester of the present invention is not particularly limited, and the monoester may be produced by a known production method. Specifically, cyclohexanedicarboxylic acid and cholesterol are used without a catalyst, or paratoluenesulfonic acid, sulfuric acid, hydrochloric acid, methanesulfonic acid, boron trifluoride diethyl ether complex or the like is used as a solvent, and heptane, hexane, etc. are used as a solvent. The reaction may be carried out at 50 to 260 ° C. using cyclohexane, toluene, xylene or the like. Further, a solvent using cyclohexanedicarboxylic acid and 1,2-cyclohexanedicarboxylic acid anhydride without a catalyst or using paratoluenesulfonic acid, sulfuric acid, hydrochloric acid, methanesulfonic acid, boron trifluoride diethyl ether complex or the like as a catalyst. It is possible to preferably obtain a monoester by reacting with heptane, hexane, cyclohexane, toluene, xylene or the like at 50 to 260 ° C. The obtained monoester may be purified and used by a usual method, if necessary, and may contain an unreacted dicarboxylic acid or diester in addition to the monoester.

The monoester of the present invention may be used in the form of a salt. The salt is not particularly limited, but specifically, alkali metal salts such as sodium and potassium; alkaline earth metal salts such as calcium and magnesium; metal salts such as aluminum, iron and zinc; lysine, arginine and histidine, Basic amino acid salts such as ornithine; organic amine salts such as ammonium, monoethanolamine, diethanolamine, triethanolamine, stearylamine and the like can be mentioned.

The monoester of the present invention has an excellent moisturizing function and is excellent in hydrolysis stability as compared with a monoester of succinic acid and cholesterol. It is presumed that this is due to the three-dimensional structure of the cyclohexane ring.

The monoester of the present invention can be used in combination with cosmetics to obtain the excellent effects of the present invention. The amount to be blended in the cosmetic is not particularly limited as long as the effect of the present invention is not impaired, and is usually 0.01 to 99% by weight, preferably 0.05 to 50% by weight.

The cosmetics of the present invention include additive components that are added to water and ordinary cosmetics as needed, such as oily bases, surfactants, alcohols, moisturizers, polymers / thickening / gelling agents, and antioxidants. Agents, preservatives, bactericides, chelating agents, pH regulators / acids / alkalis, UV absorbers, whitening agents, solvents, keratin exfoliating / dissolving agents, antipruritic agents, anti-inflammatory agents, antiperspirants, refreshing agents, antihistamines, astringents Agents, stimulants, hair growth agents / blood circulation promoters, reducing agents / oxidizing agents, polymer powders, hydroxy acids, vitamins and their derivatives, sugars and their derivatives, organic acids, enzymes, nucleic acids, hormones , Inorganic powders, fragrances, pigments, etc. can be blended.

Oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, araquil alcohol, behenyl alcohol, jojoba alcohol, chimil alcohol, seraquil alcohol, bacil alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimerdiol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Higher grades such as palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eikosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long chain branched fatty acids, dimer acid, hydrogenated dimer acid, etc. Fatty acids and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium and sodium salts, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin , Α-Olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalane, vaseline, solid paraffin and other hydrocarbons; candelilla wax, carnauba wax, rice wax, wood wax, honey wax, montan wax , Ozokerite, Celesin, Paraffin wax, Microcrystallin wax, Petrolatum, Fishertroph wax, Polyethylene wax, Ethylene-propylene copolymer and other waxes; Palm oil, Palm oil, Palm kernel oil, Saflower oil, Olive oil, Himasi oil, Avocado Oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rose hip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat Vegetable oils and fats such as germ oil, flaxseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef fat, milk fat, Animal oils and fats such as horse fat, egg yolk oil, mink oil, turtle oil; animal waxes such as whale wax, lanolin, orange raffy oil; liquid lanolin, reduced lanolin Lanolins such as adsorption-purified lanolin, lanolin acetate, liquid acetate lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate alcohol, acetic acid (cetyl lanolin) ester; lecithin, phosphatidylcholine, Sphingophospholipids such as phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, Phosphorlipid derivatives such as partially hydrogenated egg yolk phospholipids; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, isostear Cholesteryl acid, cholesteryl oleate, di-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (cholesteryl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl / Behenyl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl / octyldodecyl), acylsarcosine alkyl esters such as N-lauroyl sarcosin isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, Sunflower seed oil Sterol esters such as fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; phospholipid-cholesterol complex, phospholipid-phytosterol Lipid complexes such as complexes; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl parimitinate, octyldodecyl palmitate, cetyl octanate, hexyldecyl octanate, isotridesyl isononanoate, isononyl isononanate, isononan Octyl acid, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, neopentane Isostearyl acid, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, dicaprylic carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hardened isostearic acid, oleic acid Ethyl, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, laminolin fatty acid isopropyl, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate , Diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyl octyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate and other monoalcoholic carboxylic acid esters; cetyl lactate, diisostearyl malate, monoisostearic acid Oxyate esters such as hydrogenated castor oil, γ-ercalactone; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic acid / capric acid), tri (caprylic acid / caprylic acid) Acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl beecosanate diate, trimethylol propane trioctanoate, trimethylol propane triisostearate, dioctanoic acid Neopentyl glycol, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditriethylhexanoate Methylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, pentaerythricyl triethylhexanoate, (hydroxystearic acid / stearic acid / logonic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10 , Deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyce Polyhydric alcohol fatty acid esters such as lyl oligoester, glycol distearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopenate, 2,4-diethyl-1,5-pentanediol dineopenate; Alkyl ethers such as dicaprylyl ether; diisopropyl dimergylinolate, diisostearyl dimerserinolate, dimerserylinolate di (isostearyl / phytosteryl), dimergylinolic acid (phytosteryl / behenyl), dimergylinol acid ( Phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimerdilinoleic acid dimergylinoleil, diisostearate dimergylinoleil, dimergylinoleil hydrogenated rosin condensate, dimergylinol acid-cured castor oil, hydroxyalkyl dimerg Dimeric acid or dimerdiol derivative such as linoleyl ether; palm oil fatty acid monoethanolamide (cocamide MEA), palm oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide) Fatty acid alkanolamides such as DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitate monoethanolamide (partamide MEA), palmitate diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (Dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone / dimethicone) Copolymers, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, polyether-modified silicones such as cation-modified silicones and dimethicone copolyols, polyglycerin-modified silicones, sugar-modified silicones, and carboxylics. Acid-modified silicone, phosphate-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkylether-modified silicone, amino acid-modified silicone, peptide-modified silicone , Fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, amide alkyl-modified silicone, aminoglycol-modified silicone, aminophenyl-modified silicone, polysiloxane / oxy. Silicones such as alkylene copolymers; fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether are preferable.

Examples of the moisturizing agent / feel improving agent include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, and the like. Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and its polymers; diethylene glycol monoethyl ether Glycolalkyl ethers such as (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, polyglyceryl-10 tetradecanedioate, cyclohexanedicarboxylic acid Water-soluble esters such as bisethoxydiglycol; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, martitol; glucose, fructose, galactose, mannose, treose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, Trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, Heparin and derivatives, saccharides such as pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer and derivatives thereof; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate , Caronine sulfate, keratosulfate, dermatane sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; organic acids such as citrate, tartrate, lactic acid and salts thereof; urea; 2-pyrrolidone-5 -Dicarboxylic acids and salts such as sodium thereof; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamate, glutamine, asses Amino acids such as paragin, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and their salts; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, hydrolyzed collagen, Hydroxypropyl ammonium chloride Hydrolyzed collagen, elastin-degraded peptide, keratin-degraded peptide, hydrolyzed keratin, conchiolin-degraded peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, wheat protein Protein peptides such as degrading peptides, hydrolyzed wheat proteins, casein-degrading peptides, acylated peptides and their derivatives; acylated peptides such as palmitoyl oligopeptides, palmitoyl pentapeptides and palmitoyl tetrapeptides; silylated peptides; lactic acid bacteria culture solution , Yeast extract, eggshell membrane protein, submandibular gland mutin, hypotaurine, sesame lignan glycoside, glutathione, albumin, lactate; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extract, hamamelis water, hechima Animal / plant extracts such as water, chamomile extract, kanzo extract, comfrey extract, silk extract, isayoibara extract, sardine extract, eucalyptus extract, and melilot extract, natural ceramide (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides, sphingoglycolipids, ceramides and ceramides such as sugar ceramide-containing extracts are preferred.

Preferred examples of the surfactant include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymer surfactants. The HLB of the surfactant is not particularly limited and can be used from a low HLB of about 1 to a high HLB of about 20, and it is also preferable to combine a low HLB and a high HLB. Examples of preferred surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate and ammonium lauryl sulfate; laureth. Polyoxyethylene alkyl sulfates such as sodium sulfate and triethanolamine laureth sulfate; sodium cocoyl methyl taurine, potassium cocoyl methyl taurine, sodium lauroyl methyl taurine, sodium myristyl methyl taurine, sodium lauroyl methyl alanine, sodium lauroyl sarcosin, and lauroyl sarcosin triethanol. Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroyl glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine. , Acyl amino acid salts such as lysine Na dilauroyl glutamate; Polyoxyethylene alkyl ether acetate salts such as sodium laures acetate; Sulfonic acid ester salts such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylates; Acyl lates Polyoxyethylene fatty amine sulfate; fatty acid alkanolamide sulfate; hardened coconut oil fatty acid fatty acid glyceride sulfate such as sodium glycerin sulfate; alkylbenzene polyoxyethylene sulfate; olefin sulfonate such as α-olefin sulfonate; sulfosuccin Alkyl sulfosuccinates such as sodium lauryl sulphate, sodium dioctyl sulfosuccinate; alkyl ether sulfosuccinates such as sodium laures sulfosuccinate, monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; tetradecyl Alkyl benzene sulfonates such as sodium benzene sulfonate, triethanolamine tetradecyl benzene sulfonic acid; alkyl naphthalene sulfonate; alkane sulfonate; α-sulfo fatty acid methyl ester salt; acyl acetylionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetate; Alkyl ether phosphate such as sodium laureth phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooles phosphate; Alkyl phosphate such as potassium lauryl phosphate; Sodium caseinate; Alkyl aryl ether Phosphate; fatty acid amide ether phosphate; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, sulfate-modified silicone; Among nonionic surfactants, laures (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steares (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), isosteares (poly) Polyoxyethylene alkyl ethers with various polyoxyethylene additions such as oxyethylene isostearyl ethers) and octyldodeces (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkylphenyl ethers; polyoxyethylene hydrogenated castor oil, poly Oxyethylene castor oil, polyoxyethylene cured castor oil monoisostearate, polyoxyethylene cured castor oil triisostearate, polyoxyethylene cured castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene cured castor oil maleic acid, etc. Polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / Polyoxyethylene / polyoxypropylene alkyl such as polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether, etc. Ether; polyoxyethylene / polyoxypropylene glycol; (poly) glycerin such as PPG-9 diglyceryl Polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, pa Glyceryl luminate, glyceryl myristate, glyceryl oleate, coconut oil fatty acid glyceryl, monocotton seed oil fatty acid glycerin, glycerin monoercaate, glycerin sesquioleate, glycerin α, α'-pyroglutamate oleate, glycerin monostearate Partial esters of glycerin fatty acids; polyglyceryl-2, 3, 4, 5, 5, 6, 8, 10, distearate, polyglyceryl-6, 10, polyglyceryl tristearate-2, polyglyceryl decastarate -10, polyglyceryl isostearate-2, 3, 4, 5, 6, 8, 8, 10, polyglyceryl diisostearate-2 (diglyceryl diisostearate), 3, 10, polyglyceryl triisostearate- 2. Polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate 3, 4, 4, 5, 6, 8, 10, dioleate polyglyceryl-6, polyglyceryl trioleate -2, Polyglycerin fatty acid ester such as polyglyceryl-10 dekaoleate; ethylene glycol monofatty acid ester such as ethylene glycol monostearate; propylene glycol monofatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid Estares; multi-toll partial fatty acid esters; multi-toll ethers; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitans sesquioleate, sorbitan trioleate, penta-2 -Sorbitan fatty acid esters such as diglycerol sorbitan ethylhexylate and diglycerol sorbitan tetra-2-ethylhexylate; sugar derivative partial esters such as sucrose fatty acid ester, methylglucoside fatty acid ester and trehalose undecylate; alkyl glucosides such as caprylyl glucoside; Alkyl polyglycoside; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate and other polyoxyethylene fatty acid monos and diesters; polyoxy Ethylene / propylene Recall fatty acid ester; polyoxyethylene glycerin fatty acid ester such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene glycerin monostearate; polyoxyethylene sorbitan Polyoxyethylene sorbitan fatty acid esters such as monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate , Polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate and the like; polyoxyethylene sorbitol fatty acid ester; polyoxyethylene methyl glucoside fatty acid ester; polyoxyethylene alkyl ether fatty acid ester; polyoxyethylene sorbitol mitsuro and the like Ethylene animal and vegetable oils and fats; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimil alcohol, ceracyl alcohol, bacillus alcohol; polyhydric alcohol alkyl ether; polyoxyethylene alkylamine; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine Condensates; Natural surfactants such as saponin and sophorolipid; Polyoxyethylene fatty acid amide; Palm oil fatty acid monoethanolamide (cocamide MEA), palm oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA) ), Lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitate monoethanolamide (partamide MEA), palmitate diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA) Alcohol alkanolamides such as; alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, behenamine oxide; alkylethoxydimethylamine oxides; polyoxyethylene alkyl mercaptans; polyether modifications such as dimethicone copolyol Silicone, polysiloxane / oxyalkylene copolymer, polyglycerin modification Silicone-based nonionic surfactants such as silicones and sugar-modified silicones; among cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, stealtrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride; Alkyltrimethylammonium bromide such as stearyltrimonium bromide; Dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidamines such as stearamidepropyldimethylamine and stearamideethyldiethylamine and salts thereof; stearoxypropyldimethyl Alkyl ether amines such as amines and salts or quaternary salts thereof; fatty acid amide type quaternary ammonium salts such as ethyl sulfate long chain branched fatty acids (12-31) aminopropyl ethyl dimethyl ammonium, ethyl sulfate lanolin fatty acids aminopropyl ethyl dimethyl ammonium; Polyoxyethylene alkylamine and its salt or quaternary salt; alkylamine salt; fatty acid amide guanidium salt; alkyletheraminemonium salt; alkyltrialkylene glycolammonium salt; benzalconium salt; benzethonium salt; cetylpyridinium chloride, etc. Pyridinium salt; imidazolinium salt; alkylisoquinolinium salt; dialkylmoriphonium salt; polyamine fatty acid derivative; amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cationic-modified silicone, cationic-modified and polyether-modified silicone, amino Silicone-based cationic surfactants such as modified and polyether-modified silicones; among amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryl dimethylaminoacetic acid betaine); cocamidopropyl Fatty acids such as betaine and lauramidopropyl betaine Alkyl-N, N-dimethylamino acid betaine; imidazoline-type betaine such as sodium cocoamphoacetate and sodium lauroammonium acetate; alkylsulfobetaine such as alkyldimethyltaurin; alkyldimethylaminoethanol sulfate ester and the like Sulfate-type betaine; Phosphate-type betaine such as alkyldimethylaminoethanol phosphate: Phosphati containing myristic acid, palmitic acid, stearic acid, arachidonic acid, oleic acid, linoleic acid, linolenic acid, etc. as constituent fatty acids of phospholipids. Sphingophospholipids such as zyrcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, lecithin hydroxide, etc. Phospholipids; Silicone-based amphoteric surfactants, etc .; Among polymer surfactants, polyvinyl alcohol, sodium alginate, starch derivatives, traganth gum, acrylic acid / alkyl methacrylic acid copolymers; various silicone-based surfactants are preferable. Is listed as.

Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, farcerelan, karaya gum, trolley aoi, cara gum, tragant gum, pectin, pectic acid and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potatoes, wheat; xanthan gum, dextran, succinoglucan, curdran, hyaluronic acid and its salts, zansan gum, purulan, gellan gum, chitin , Chitosan, agar, casso extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts such as sodium thereof, methyl hydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethyl Cellulose sulfate, crystalline cellulose, cellulose powder and other cellulose and derivatives thereof; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch and methyl starch, hydroxypropyltrimonium chloride starch, corn starch aluminum octenyl succinate and the like. Alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpidridone / vinyl alcohol copolymer, polyvinylmethyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene Polyoxypropylene copolymer; amphoteric methacrylate copolymer such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrelites / stearyl acrylate / ethylamine methacrylate) copolymer; (dimethicone / vinyldimethicone) cloth Polymers, (alkyl acrylate / diacetone acrylamide) copolymers, (alkyl acrylate / diacetone acrylamide) copolymers AMP; partially saponified polyvinyl acetate, maleic acid copolymers; vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymers; Acrylic resin alkanolamine; polyester, water-dispersible polymer; polya Crylamide; polyacrylic acid ester copolymer such as ethyl polyacrylic acid, carboxyvinyl polymer, salt such as polyacrylic acid and sodium salt thereof, acrylic acid / methacrylic acid ester copolymer; acrylate / alkyl methacrylic acid Polymers: cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid such as polyquaternium-39. -Diallyldimethylammonium chloride-acrylamide copolymer, acrylic acid-cationized methacrylic acid ester copolymer, acrylic acid-cationized methacrylic acid amide copolymer, polyquaterium-47 and other acrylic acid-methyl acrylate-chloride Methacylamide propyltrimethylammonium copolymer, choline chloride methacrylate polymer; cationized oligosaccharide, cationized dextran, cationized polysaccharide such as guarhydroxypropyltrimonium chloride; polyethyleneimine; cationic polymer; polyquaternium-51 and the like. 2-Polymer of methacryloyloxyethyl phosphorylcholine and polymer with butyl methacrylate copolymer, etc .; acrylic resin emulsion, ethyl polyacrylate emulsion, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic Polymer emulsions such as latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and Its salts; dextrin fatty acid esters such as dextrin palmitate, dextrin myristinate; silicic anhydride, fuming silica (ultrafine anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, metal dialkyl phosphate, Bentonite, hectrite, organically modified clay minerals, sucrose fatty acid esters, fructo-oligosaccharide fatty acid esters are preferred.

Examples of solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyldiol. Kind: Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as: ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, glycol ether esters such as propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl Preferables include propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation freon; LPG, dimethyl ether, and carbon dioxide.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; bisulfite derivatives such as propyl bisulfite; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; Sulfites such as sodium sulfite; hydrogen sulfites such as sodium hydrogen sulfite; thiosulfites such as sodium bisulfite; metahydrosulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferable. Is listed as. As the reducing agent, thioglycolic acid, cysteine, cysteamine and the like are preferable. As the oxidizing agent, hydrogen peroxide solution, ammonium persulfate, sodium bromate, percarbonate and the like are preferable.

Examples of antibacterial agents or preservatives include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane. 1,2-Alcandiols such as diols; Alkylglyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); Salicylic acid; Sodium benzoate; Isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; Imidazo Linium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zincpyrythion, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, glucon Chlorhexidine acid, halocarban, hexachlorophenol, hinokithiol; other phenols such as phenol, isopropylphenol, cresol, timol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion However, when used as an antibacterial agent or an antiseptic for the purpose of antiseptic, from the viewpoint of safety of cosmetics or external preparations for skin, phenoxyethanol; 1,2-pentanediol, 1,2-hexane It is more preferable to use 1,2-alkanediols such as diols and 1,2-octanediols; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ethers.

Examples of the chelating agent include edetates (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytate; ethidroic acid and the like. Phosphonic acid and salts such as sodium salt thereof; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphate; sodium citrate, citric acid, alanine, dihydroxyethylglycine , Gluconic acid, ascorbic acid, succinic acid, tartrate acid are preferred. Acids and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, and monoethanol. Amin, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxide Preferred are sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate and ammonium carbonate.

Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, white mica, gold mica, synthetic mica, red mica, black mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, cay. Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (eg zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, dark blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide , Fine particles and ultrafine zinc oxide, alumina, silica, fumigant silica (ultrafine anhydrous silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine gold mica, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with silicones such as hydrogen silicone and cyclic hydrogen silicone or other surface treatment agents such as silane or titanium coupling agents to make them hydrophobic or Inorganic powders such as hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethylmethacrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate. -Polymethylmethacrylate laminated powder, polyethylene terephthalate, aluminum, epoxy laminated powder, etc., urethane powder, silicone powder, Teflon (registered trademark) powder, and other organic powders and surface treatment powders of various sizes and shapes, organic and inorganic Composite powders are preferred. Inorganic salts include sodium chloride-containing salts such as salt, normal salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, ginger, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, etc. Aluminum / potassium sulfate (myoban), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na / 2Na / 3Na phosphate, phosphoric acid Potassiums, calcium phosphates and magnesium phosphates are preferred.

Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, N, N-dimethylparaaminobenzoate ethyl. An benzoic acid-based ultraviolet absorber such as ester, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorber such as homomentyl-N-acetylanthranilate; salicylic acid And salicylic acid-based ultraviolet absorbers such as sodium salt, amylsalicylate, menthylsalicylate, homomentylsalicylate, octylsalicylate, phenylsalicylate, benzylsalicylate, p-isopropanol phenylsalicylate; octylcinnamate, ethyl-4-isopropylcinnamate, methyl. -2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy Synnamete, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Ceramic acid-based ultraviolet absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate (octocrine), glycerylmono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and derivatives thereof; 2, 4-Dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-Methoxybenzophenone (oxybenzon-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' Benzophenones such as −phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone Ultraviolet absorbers; 3- (4'-methylbenziliden) -d, l-phenyl, 3-benziliden-d, l-phenyl; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 -Methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoilmethane; 5-( 3,3-Dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octylriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate 2- (2'-Hydroxy-5'-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentandione, dimethoxybenzilidendioxoimidazolidine propionic acid Hydantin derivatives such as 2-ethylhexyl, phenylbenzimidazole sulfonic acid, terephthalilidene dicanfursulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives are preferred.

Examples of the whitening agent include hydroquinone glycosides such as arbutin and α-arbutin and their esters; ascorbic acid, ascorbic acid phosphate sodium salt, ascorbic acid phosphate ester magnesium salt and the like, ascorbic acid phosphate ester salt, ascorbic acid. Ascorbic acid fatty acid ester such as tetraisopalmitic acid ester, ascorbic acid alkyl ether such as ethyl ether ascorbic acid, ascorbic acid glucoside such as ascorbic acid-2-glucoside and its fatty acid esters, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as: kodic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble kanzo extract, Nishikawayanagi extract, Yukinoshita extract Ascorbic acid is preferred.

Examples of vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxin hydrochloride, pyridoxin dioctanoate, pyridoxin dipalmitate, etc. Vitamin B group such as flavin adenin dinucleotide, cyanocobalamine, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin E such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate ester salt such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt, tetra ascorbic acid Ascorbic acid fatty acid ester such as isoparmic acid ester, ascorbic stearate, ascorbic palmitate, ascorbic dipalmitate, alkyl ether ascorbic acid such as ethyl ether ascorbic acid, ascorbic acid glucoside such as -2-glucoside ascorbic acid and its fatty acid ester , Ascorbic acid derivatives such as tocopheryl ascorbic acid; tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, tocopherol derivatives such as tocopherol phosphate, and other vitamin derivatives, tocotrienol, and other various vitamin derivatives are preferable. Is listed as.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokithiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, difedramine hydrochloride, chlorpheniramine maleate; peach leaf extract. , Plant extracts such as Honoha extract are preferred. As hair growth agents, blood circulation promoters, and stimulants, plant extracts and tinctures such as senburi extract, capsicum tincture, ginger tincture, gypsum tincture extract, and cantalis tincture; capsaicin, nonylate warenylamide, zingerone, ictamol, and tannic acid. , Borneol, cyclanderate, cinnaridine, trazoline, acetylcholine, verapamil, cepharanthin, γ-orizanol, cepharanthin, vitamin E and derivatives such as tocopherol nicotinate / tocopherol acetate, γ-orizanol, nicotinic acid and nicotinic acid amide / benzyl nicotinate. Derivatives such as ester inositol hexanicotinate and nicotine alcohol, allantin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivative, stigmasterol or stigmasterol and its glycoside, minoxidil are preferable. Is listed as. As the hormones, estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like are preferable. Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cold sensitizers, warming agents, wound healing promoters, irritation palliatives, analgesics, cell activators, etc. include retinols, retinoic acids, retinoins. Tocopheryl acid; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and its glycosides / esterified products, hydroxycapric acid, long-chain α-hydroxy fatty acid, long-chain α-hydroxy fatty acid cholesteryl and other α- or β-Hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosin; creatin; ceramides, spingosines; caffeine, xanthin and its derivatives; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloids, fullerene and other antioxidant / active oxygen scavengers; catechins; quercetin and other flavones; isoflavones; gallic acid and ester sugar derivatives; tannins, sesamine, proto Polyphenols such as anthocyanidin, chlorogenic acid, apple polyphenols; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; kanzo extract-related substances such as glabridin, glabrene, liquilithin, isoliquilithin; lactoferrin Glycoside, gingerol; fragrance substances such as menthol, camphor, sedrol and derivatives thereof; capsaicin, vanillin and derivatives; insect repellents such as diethyl toluamide; complexes of physiologically active substances and cyclodextrins are preferred. Can be mentioned.

Plant / animal / microbial extracts include iris extract, acitaba extract, asunaro extract, asparagus extract, avocado extract, flaxseed extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract. , Inchikou extract, Uikyo extract, Ukon extract, Woolong tea extract, Uwaurushi extract, Agetsu extract, Echinashi leaf extract, Enmeisou extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otanenjinjin extract, Otogirisou extract, Odori kosou extract, Ononis extract , Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cucumber extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomogi Extract, crow wheat extract, calcade extract, kanzo extract, oil-soluble kanzo extract, kiwi extract, kiou extract, kikurage extract, kina extract, cucumber extract, kiri leaf extract, guanosine, guava extract, kujin extract, kuchinashi extract, kumazasa extract, clara extract, walnut Extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, quail extract, gentiana extract, gennoshouko extract, tea extract, yeast extract, koboku extract, coffee extract, gobo extract, rice extract, rice Fermented extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, moss peach extract, saishin extract, psycho extract, saitai extract, saffron extract, salvia extract, sabonsou extract, sasa extract, sanzashi extract, sansha extract, sansho Extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Jatoba extract, Shakuyaku extract, Shokyu extract, Shobu root extract, Shirakaba extract, White chrysanthemum extract, Sugina extract, Stevia extract, Stevia fermented product, Nishikawayanagi extract, Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogirisou extract, Seiyouhakka extract, Sage extract, Zeniaoi extract, Senkyu extract, Senburi extract, Souhakuhi extract, Daiou extract, Dai Zu extract, Taisou extract, Thyme extract, Dandelion extract, Local clothing extract, Tea extract, Chouji extract, Chigaya extract, Chinpi extract, Tea tree oil, Jincha extract, Togarashi extract, Touki extract, Tokinsenka extract, Tounin extract, Tohi extract, Dokudami extract, Tomato Extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Hass extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Paris etalia extract, Hikiokoshi extract, Bisaborol, Hinoki extract, Bifizus bacterium extract, Biwa extract, Fukitanpopo extract, Fukinotou extract, Bukuryo extract, Butcher bloom extract, Grape extract, Grape seed extract, Propolis, Hechima extract, Benibana extract, Peppermint extract, Bodaiju extract, Button extract, Hop extract, Maikaika extract, Pine extract, Maronie extract , Mizubasho extract, Mukuroji extract, Melissa extract, Mozuku extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yuzu extract, Yuri extract, Yokuinin extract, Yomogi extract, Lavender extract, Green tea extract, Eggshell membrane extract, Apple extract, Louis Boss tea extract , Reishi extract, lettuce extract, lemon extract, lotus extract, lotus extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, crackle extract and the like are preferable.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate and the like. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid and the like. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease and the like. Preferred examples of nucleic acids include ribonucleic acid and a salt thereof, deoxyribonucleic acid and a salt thereof, and disodium adenosine triphosphate.

Fragrances include acetylsedrene, amylcinnamaldehyde, allylamylglycolate, β-ionone, isoesuper, isobutylquinolin, iris oil, iron, indol, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragor, Eugenol, Oak Moss, Opoponax Resinoid, Orange Oil, Eugenol, Oranthiol, Galax Solid, Carbachlor, L-Carbon, Kamfer, Cannon, Carrot Seed Oil, Clove Oil, Methyl Caynate, Geraniol, Geranyl nitrile , Isobornyl acetate, Geranyl acetate, Dimethylbenzylcarvinyl acetate, Styralyl acetate, Cedril acetate, Telepinel acetate, pt-butylcyclohexyl acetate, Vetiberyl acetate, benzyl acetate, Linaryl acetate, Isopentyl salicylate, benzyl salicylate, Sandalwood oil, Santa roll, Cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citroneral, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylux Reginoid, Cedarwood Oil, Sedren, Sedrol, Celori Seed Oil, Thyme Oil, Damascon, Damasenon, Timor, Tuberose Absolute, Decanal, Decalactone, Terpineol, γ-Terpinen, Triplar, Nerol, Nonanar, 2,6-Nonadienor, Nonalactone, Pacholi Alcohol, vanilla absolute, vanillin, basil oil, patcholi oil, hydroxycitroneral, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil, vetiverol , Peppermint oil, pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, muskketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-mentone, eucalyptus oil, β-yonone, lime oil , Lavender oil, D-limonen, linalol, lylar, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, synthetic fragrances such as various essential oils and natural Fragrances and various blended fragrances are preferred.

As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213 , Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1 , Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505 , Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1 , Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow Legal dyes such as No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p- phenylenediamine, HC Blue 2, Basic Blue 26 and other nitro dyes; Disperse dyes; Titanium dioxide, Zinc oxide Inorganic white pigments such as; Inorganic red pigments such as iron oxide (Bengala) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and ocher; Black iron oxide, low Inorganic black pigments such as next titanium oxide; Inorganic purple pigments such as mango violet and cobalt violet; Inorganic green pigments such as dye, chromium hydroxide, cobalt titanate; inorganic blue pigments such as ultramarine and dark blue; titanium oxide coated mica, titanium oxide coated oxybismus chloride, titanium oxide coated talc, colored titanium oxide coated mica, oxy Pearl pigments such as bismuth chloride and fish scale foil; metal powder pigments such as aluminum powder, copper powder and gold; surface-treated inorganic and metal powder pigments; red 201, red 202, red 204, red 205, red 220 , Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red Organic pigments such as zirconium, barium or aluminum lakes such as 230, red 401, red 505, orange 205, yellow 4, yellow 5, yellow 202, yellow 203, green 3 and blue 1. Surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsantin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, naphthoquinones such as ciconin, bixin, flavones, beta Natural pigments and dyes such as cyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5- Oxidation dye intermediates and couplers such as amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and salts thereof; automatic oxidation dyes such as indolin; dihydroxyacetones are preferred.

As the water, in addition to normal water and purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionized water, electrolytically acidic ionized water, ionized water, and cluster water are preferable.

In addition to these, cosmetic raw material standards, compounding ingredient standards by cosmetic type, Japanese Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), non-pharmaceutical raw material standards, Japanese Pharmacy, pharmaceutical additives Ingredients described in standards, official standards for food additives, etc., and in Japanese and foreign patent gazettes and patent publication gazettes (including publication gazettes and republications) whose international patent classification IPC belongs to the classification of A61K7 and A61K8. It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the described ingredients, in known combinations, blending ratios, and blending amounts.

Examples of the type of cosmetics of the present invention include hair cosmetics, basic cosmetics, make-up cosmetics, aromatic cosmetics, body cosmetics, skin external preparations such as ointments, and the like. The cosmetic of the present invention can be produced according to a usual method.

Explaining the types of the cosmetics of the present invention in more detail, the hair cosmetics include shampoos such as oil shampoo, cream shampoo, conditioning shampoo, indulgence shampoo, hair coloring shampoo, and rinse-integrated shampoo; rinse, treatment. , Hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow, split hair coat, hair oil, permanent Wave agents, straight perms, oxidative hair dyes, hair bleaches, hair color pretreatments, hair color aftertreatments, perma pretreatments, perma aftertreatments, hair manicures, and hair restorers are preferred.

Basic cosmetics include softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisturizer, moisturizer. -Emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sun screen, make-up lotion, horny smoother, elbow lotion, hand lotion, body lotion and other emulsions; emollient cream, nutrition cream, Nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, make-up cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening Creams such as creams; Gels such as moisture gels; Essences such as moisturizing essences, whitening essences, and UV protection essences; Lipstick cosmetics such as liposome beauty liquids and liposome cosmetics; Peel-off packs, powder packs, washing packs, oil packs, cleansing Packs and masks such as masks; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, cleansing powder, facial cleansing powder, etc.; cosmetic soap, transparent soap, medicated soap, liquid soap, Soaps such as shaving soaps and synthetic cosmetic soaps are preferred.

Preferable makeup cosmetics include white powder / dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment. ..

Preferable aromatic cosmetics include perfumes, perfumes, parfum, eau de parfum, eau de toilette, cologne, perfumes, fragrance powders, perfume soaps, body lotions, and bath oils.

Body cosmetics include body cleaning agents such as body shampoo; deodorant cosmetics such as deodorant lotion, deodorant powder, deodorant spray, and deodorant stick; depigmenting agents, depilatory / depilatory agents; bathing agents; insect repellent sprays, etc. Repellers are preferred.

As the external preparation for skin, it can be used in a dosage form such as an ointment, a patch, a lotion, a liniment, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

Examples of the dosage form of the cosmetic or external preparation for skin of the present invention include oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, and O / in combination with a surfactant. Emulsified cosmetics such as W / O type, liposome cosmetics combined with phospholipids, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder Preferred dosage forms include form cosmetics, jelly form cosmetics, gel form cosmetics, paste form cosmetics, emulsified polymer type cosmetics, sheet form cosmetics, mist form cosmetics, spray type cosmetics and the like. ..

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

Synthesis Example 1 Synthesis of monocholesteryl 1,2-cyclohexanedicarboxylic acid 30.0 g (0.19) of 1,2-cyclohexanedicarboxylic acid anhydride in a 500 mL reactor equipped with a stirrer, thermometer, gas introduction tube, and cooling tube. Mol), 62.7 g (0.16 mol) of cholesterol and 200 g of toluene as a solvent were charged, heated to 110-120 ° C. in a nitrogen stream, and reacted for 8 hours. After the reaction, 14.8 g of methyl ethyl ketone and 59.1 g of purified water were added, and the organic layer was washed with water at 50 to 60 ° C. Further, after repeating washing with water until the aqueous layer became neutral, the organic layer was concentrated. Next, heptane was added to the concentrate to dissolve it, and the mixture was cooled to 5 ° C. for crystallization and filtration. The obtained crystals were rinsed with cold heptane and dried under reduced pressure at 25 ° C. for 24 hours to obtain 63.5 g of the target monocholesteryl 1,2-cyclohexaneate as white crystals (yield 72. 4%).

Moisturizing Evaluation A milky lotion containing the monoester of the present invention obtained in Synthesis Example 1 was prepared with the composition shown in Table 1. Further, as a comparison, a milky lotion containing no monoester of the present invention was prepared (Comparative Example 1). The inner part of the forearm of 5 panelists was used as a measurement site, and a fixed amount of the emulsion of Example 1 or Comparative Example 1 was applied to a range of 2 × 2 cm. The water content (conductance) of the stratum corneum was measured with SKICON-200EX (manufactured by Yayoi Co., Ltd.) before coating, and after 1 hr, 2 hr, 4 hr, and 8 hr of the coated portion. The coating and measurement were carried out after acclimatizing the panelist to an environment of 20 ° C. and 50% humidity for 20 minutes or more. The result was a relative value obtained by 100% before application, and was shown as an average value of 5 panelists. The results obtained are also shown in Table 1. From the results shown in Table 1, the monoester of the present invention showed a significantly higher water content in the stratum corneum than the emulsion containing no monoester of the present invention. Therefore, it was considered that the monoester of the present invention imparts a moisturizing effect when blended in cosmetics.

Evaluation of Stability 0.5 g of each of the monoester of the present invention obtained in Synthesis Example 1 and monocholesteryl succinate for comparison were weighed in a 20 mL screw tube, and 0.5 g of purified water was further added to water the mixture. The obtained hydrous was stored at 50 ° C., and after 2 and 4 weeks, 9.5 g of purified water was further added to prepare a 5% aqueous dispersion, and the pH of the aqueous dispersion was measured. The results are shown in Table 2. From the results in Table 2, it was found that the monoester of the present invention is excellent in hydrolysis stability, so that the decrease in pH is small and the stability in cosmetics is excellent.

The cosmetics described below were prepared using the monoester of the present invention. The obtained cosmetics had excellent moisturizing properties.

Example 2 Emulsion Using the monoester of the present invention, an emulsion having the following formulation was prepared.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3,
Ceramide 6II (Phytocompo-C: Nippon Fine Chemical Co., Ltd.) 1.0
Hydrogenated lysolecithin (LP70H: Nippon Fine Chemical Co., Ltd.) 0.1
Compound 0.5 of Synthesis Example 1
Part B Triethylhexanoin (IOTG: Nippon Fine Chemical Co., Ltd.) 3.0
Dimer dilinoleic acid dimer dilinoleil,
Tri (caprylic acid / capric acid) glyceryl (LUSPLAN SR-DM4: Nippon Fine Chemical Co., Ltd.) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Setostearyl alcohol 1.0
Arachidyl alcohol 0.1
Jojoba Alcohol 3.0
Kimil alcohol 0.3
Ceraquil Alcohol 0.1
Hexildecanol 0.5
Part C Hydroxyethyl Acrylate / Acryloyl Dimethyltaurine Na) Copolymer 0.2
White fungus polysaccharide (Tremost-TP: Nippon Fine Chemical Co., Ltd.) 0.03
Carbomer 0.1
Purified water 20.0
Part D (icosanedioic acid / tetradecanedioic acid) polyglyceryl-10, glycerin (Neosolue-AquaS: Nippon Fine Chemical Co., Ltd.) 0.5
Polyquaternium-51 1.0
Ascorbyl glucoside 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 3 Emulsion Using the monoester of the present invention, an emulsion having the following formulation was prepared.

Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Hydrogenated lecithin, phytosterols, BG, glycerin (Phytocompo-SP: Nippon Fine Chemical Co., Ltd.) 8.0
Risophospholipid (LP70H: Nippon Fine Chemical Co., Ltd.) 0.1
Compound 0.3 of Synthesis Example 1
Part B Squalene 4.0
Tri (caprylic acid / capric acid) glyceryl (Neosolue-MCT: Nippon Fine Chemical Co., Ltd.) 4.0
α-olefin oligomer 2.5
Cyclopentasiloxane 3.5
Cetanol 1.5
Glyceryl stearate 1.0
Part C Hydroxyproline 0.05
Citric acid 0.01
Na citrate 0.09
Arbutin (Nippon Fine Chemical Co., Ltd.) 3.0
Phenoxyethanol 0.3
Methylparaben 0.1
Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.1
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A to C were taken, heated to about 70 ° C., and mixed uniformly. Part B was gradually added to part A while stirring with a homodisper, and then part C was added at about 70 ° C. for emulsification. Then it was cooled to about 40 ° C.

Example 4 Skin Care Cream Using the monoester of the present invention, a cream having the following formulation was prepared.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 12.0
BG 6.0
Hydrogenated lecithin, phytosterols (Phytocompo-PP: Nippon Fine Chemical Co., Ltd.) 2.5
Compound 0.5 of Synthesis Example 1
Part B Olive Fruit Oil 3.0
Olive oil 1.5
Shea butter 1.0
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical Co., Ltd.) 3.0
Sucrose stearate 0.8
Cetearyl glucoside 1.2
Behenyl alcohol 1.5
Ascorbyl Tetrahexyl Decanoate 7.0
Lauroyl sarcosine isopropyl 2.0
Hydrogenated cocoglyceryl 3.0
Cetanol 2.5
Sorbitan stearate 0.8
Part C xanthan gum 0.05
White fungus polysaccharide (Tremost-SL: Nippon Fine Chemical Co., Ltd.) 1.0
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
Sodium metabisulfite 0.03
Arbutin (Nippon Fine Chemical Co., Ltd.) 1.0
Tranexamic acid (Nippon Fine Chemical Co., Ltd.) 1.0
Part D Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolue-Aquolio: Nippon Fine Chemical Co., Ltd.) 1.0
Propanediol 3.0
Methylparaben 0.1
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 5 Skin Care Cream Using the monoester of the present invention, a cream having the following formulation was prepared.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 10.0 of Synthesis Example 1
Macademia nut fatty acid phytosteryl (Plandol-MAS: Nippon Fine Chemical Co., Ltd.) 2.0
Di-lauroyl glutamate (octyldodecyl / phytosteryl / behenyl)
(Plandol-LG1: Nippon Fine Chemical Co., Ltd.) 1.0
Paraffin wax 3.0
Shea butter 3.0
Squalene 8.0
Cetanol 1.8
Hydrogenated cocoglyceryl 0.8
Glyceryl stearate 1.0
PEG-60 glyceryl isostearate 1.3
Behenyl alcohol 1.5
Sorbitan stearate 1.0
Methyl Glucose Sesquistearate 1.5
Part B xanthan gum 0.1
Hydroxyethyl cellulose 0.1
Crystalline cellulose powder 0.3
Stearoxy hydroxypropyl methylcellulose 0.1
Purified water 20.0
Part C Glycerin 8.0
DPG 5.0
Sorbitol 2.0
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and C were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part B was mixed and stirred to give a viscous liquid. Part C was added while stirring with a homomixer to emulsify part A. After cooling, part B was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 6 Hand cream Using the monoester of the present invention, a hand cream having the following formulation was prepared.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 2.0 of Synthesis Example 1
Lanolin fatty acid cholesteryl (YOFCO CLE-S: Nippon Fine Chemical Co., Ltd.) 5.0
LUSPLAN SR-DM4 (Nippon Fine Chemical Co., Ltd.) 0.1
Squalene 8.0
Macademia nut oil 0.5
Rosehip oil 1.0
Meadowfoam oil 1.0
Vaseline 15.0
Microcrystalline wax 2.0
Glyceryl stearate 2.0
Cetanol 2.0
Cetyl phosphate 1.0
Beeswax 3.0
Propylparaben 0.1
Tocopherol 0.05
Perfluoropolyether 1.0
Part B Glycerin 8.0
Propanediol 5.0
Methylparaben 0.1
Ethylhexyl glycerin 0.5
Phenoxyethanol 0.3
(Acrylic Acid / Alkyl Acrylic Acid (C10-30)) Copolymer 0.1
Na hydroxide 0.5
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part B was heated to about 70 ° C. and dissolved. Part A was placed in another container and heated to about 80 ° C. to dissolve it. Part A was added to part B with stirring with a homomixer and emulsified. After emulsification, it was cooled to about 40 ° C.

Example 7 Toner A lotion having the following formulation was prepared using the monoester of the present invention.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 0.02 of Synthesis Example 1
Hydrogenated lecithin 0.30
PEG-60 hydrogenated castor oil 0.10
Phytosterol 0.02
1,3-butylene glycol 6.00
1,2-Pentanediol 2.00
Glycerin 2.00
Part B Phenoxyethanol 0.20
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was heated to about 80 ° C. in a separate container and dissolved uniformly. Part B was added to part A, emulsified with a homomixer, and then cooled to 40 ° C.

Example 8 Gel Toner Using the monoester of the present invention, a toner having the following formulation was prepared.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 0.5
Glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl behenate 0.8
Compound 0.5 of Synthesis Example 1
Stearic acid 0.3
PEG-20 hydrogenated castor oil 0.1
Polyglyceryl oleate-10 0.1
Part B Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexyl glycerin 0.2
Poly HEMA Glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Hyaluronate Na 0.01
Carbomer 0.06
Hydroxide K 0.05
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated to about 70 ° C. and uniformly dispersed. Part B was mixed, stirred well, made uniform, and then heated to about 70 ° C. Part B was added to part A, stirred at about 70 ° C. using a homomixer, and cooled to about 40 ° C.

Example 9 Body shampoo A body shampoo having the following formulation was prepared using the monoester of the present invention.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Compound 0.1 of Synthesis Example 1
Cocoyl methyl taurine Na 10.0
Lauroyl hydrolyzed silk Na 6.0
Lauroylmethylalanine Na 10.0
Na cocoamphoacetate (30%) 4.0
Cocamidopropyl Betaine (30%) 10.0
Olefin (C14-16) Na Sulfonate 5.0
Polyquaternium-10 1.3
Guar Hydroxypropyltrimonium Chloride 0.8
Acetyl hyaluronic acid Na 0.02
Cocamide DEA 3.0
Glycerin 5.0
Methylparaben 0.2
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
All components were heated at about 80 ° C. and uniformly stirred and mixed.

Example 10 Shampoo A shampoo having the following formulation was prepared using the monoester of the present invention.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Compound 0.1 of Synthesis Example 1
Di (octyldodecyl / phytosteryl) lauroyl glutamate
(Plandol-LG2: Nippon Fine Chemical Co., Ltd.) 0.03
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.1
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 0.5
Laureth-4 Carboxylate Na (28%) 10.0
Laureth-6 Carboxylic Acid 4.0
Cocamidopropyl Betaine (30%) 10.0
Lauroylmethylalanine Na (30%) 5.0
Cocamidomethyl MEA 3.0
Coconut oil fatty acid PEG-7 glyceryl 5.0
Na hydroxide 1% solution 0.5
Polyquaternium-10 0.8
Glycol distearate 0.5
Polyquaternium-7 0.5
EDTA-2Na 0.05
Methylparaben 0.2
Phenoxyethanol 0.4
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
All components were heated at about 80 ° C. and uniformly stirred and mixed.

Example 11 Hair Treatment A treatment of the following formulation was prepared using the monoester of the present invention.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 0.5 of Synthesis Example 1
Dodecane 1.5
Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 0.2
Candelilla wax 0.2
Cetyl Esters 0.3
Stearyl ethyl hexaneate 1.0
Cetearyl alcohol 3.5
PEG-200 0.5
Hydroxyethyl cellulose 0.4
Setrimonium chloride (30%) 1.0
Behentrimonium chloride (80%) 1.0
Trideces-6 0.3
BHT 0.03
Part B Methylparaben 0.2
Citric acid 0.05
Amount of purified water totaling 100 Part C PPG-3 myristyl 0.5
Isodecyl neopentane (DUB VCI-10: Nippon Fine Chemical Co., Ltd.) 1.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part B was heated to about 80 ° C. and dissolved. Part A was added to another container, and the mixture was heated and dissolved. Part B was gradually added to part A and mixed uniformly. Part C was added with stirring at about 50 ° C. to make it uniform.

Example 12 Lipstick Using the monoester of the present invention, a lipstick having the following formulation was prepared.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Compound 1.0 of Synthesis Example 1
Phenyltrimethicone 2.0
Neosolue-MCT (Nippon Fine Chemical Co., Ltd.) 12.0
Isotridecyl isononanoate 8.0
Microcrystalline wax 5.0
Polyethylene, microcrystalline wax 10.0
Paraffin wax 3.0
Beeswax 1.5
Dimer dilinoleic acid dimer dilinoleyl bis (behenyl / isostearyl / phytosteryl) (Plandol-G: Nippon Fine Chemical Co., Ltd.) 5.0
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 6.0
Di-lauroyl glutamate (octyldodecyl / phytosteryl / behenyl)
(Plandol-LG3: Nippon Fine Chemical Co., Ltd.) 3.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Diisostearyl malate A total amount of 100 Hydrogenated polyisobutene 6.0
Sorbitan isostearate 0.1
Calcium carbonate 5.0
Sulfate Ba 0.5
Al 0.5 hydroxide
Methylparaben 0.1
BHT Appropriate amount Titanium oxide 0.8
Red 202 10.0
Iron oxide 6.6
Isohexadecane 5.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
All the components were uniformly mixed with stirring at about 80 ° C., and then rapidly cooled.

Example 13 Foundation Using the monoester of the present invention, a foundation having the following formulation was prepared.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 5.0 of Synthesis Example 1
Cyclopentasiloxane 4.0
Mineral oil 4.0
Ethylhexyl methoxycinnamate 3.0
Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl /
Stearyl / Behenyl) (Plandol-H: Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Vaseline 1.0
Phenyltrimethicone 2.0
Sorbitan isostearate 1.5
Tribehenin 0.5
(Butyl acrylate / glycol dimethacrylate) Cross polymer, silica,
(Methyl methacrylate / glycol dimethacrylate) Cross-polymer mixture
2.0
Boron Nitride 1.0
PEG / PPG-19 / 19 dimethicone, cyclopentasiloxane mixture
4.0
Gistear dimonium hectorite (20%) 2.5
Polypropylsilsesquioxane, cyclopentasiloxane mixture 1.0
Mica 15.0
Talc 4.0
Zinc oxide 5.0
Titanium oxide 10.0
Iron oxide 1.5
Part B Water Total amount of 100 DPG 4.0
Maltitol (75% solution) 1.0
Neosolue-Aqua (Nippon Fine Chemical Co., Ltd.) 0.4
Na Chloride 1.0
BG 1.0
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Hyaluronic acid (1% solution) 0.1
Phenoxyethanol 0.3
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was heated to about 70 ° C., stirred well and dispersed uniformly. Part B was heated to about 70 ° C. to make it uniform, then part B was added to part A, stirred and emulsified at about 70 ° C., and cooled to about 40 ° C.

Example 14 Cream Using the monoester of the present invention, a cream having the following formulation was prepared.

Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Mineral oil 7.8
Vaseline 7.0
Squalene 0.2
Jojoba oil 0.15
Microcrystalline wax 2.4
Paraffin wax 2.0
Al 0.9 distearate
Hydrogenated polyisobutene 2.8
Lanolin alcohol (Ecolano AL-E: Nippon Fine Chemical Co., Ltd.) 2.3
Octyldodecanol 3.0
Compound 1.0 of Synthesis Example 1
Part B Magnesium Sulfate 0.5
Na benzoate 0.1
Concentrated glycerin 3.5
Amount of purified water totaling 100 Part C Mg stearate 0.9
Cyclomethicone 2.5
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and B are heated and dissolved to uniformly disperse. Part B is gradually added to part A to emulsify. The dispersed part C is blended and cooled with stirring.

Example 15 Lip balm Using the monoester of the present invention, a lip balm having the following formulation was prepared.

Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Liquid lanolin (Nippon Fine Chemical) A total amount of 100 Neosolue-MCT (Nippon Fine Chemical) 20.0
Candelilla Row 10.0
Purified lanolin (Nippon Fine Chemical Co., Ltd.) 5.0
Beeswax 3.0
Compound 1.0 of Synthesis Example 1
Stearic acid 1.0
Olive oil 1.0
Squalene 1.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
All components were heated and melted and mixed uniformly.

Example 16 Sunscreen Cosmetics Using the monoester of the present invention, sunscreen cosmetics having the following formulation were prepared.

Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
BG 10.0
Glycerin 9.0
Part B Octocrylene 4.0
Octyl salicylate 4.0
Diethylaminohydroxybenzoyl hexyl benzoate 2.25
t-Butylmethoxydibenzoylmethane 1.0
Diethylhexyl sebacate (Neosolue-EHS: Nippon Fine Chemical Co., Ltd.) 3.0
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical Co., Ltd.) 2.0
Diisopropyl sebacate (IPSE: Nippon Fine Chemical Co., Ltd.) 1.0
Compound 1.0 of Synthesis Example 1
Behenyl alcohol 2.0
Cetearyl alcohol 2.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Tocopherol 0.05
Part C Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Methylparaben Appropriate amount Water Amount that totals 100 Part D Xanthan gum (2%) 5.0
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 10.0
Water-dispersed titanium oxide 5.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Disperse part A evenly. Parts B and C are each heated and dissolved at about 70 ° C. After gradually adding the B part to the A part, the C part is gradually added and emulsified. Cool while stirring, add part D at 45 ° C, and stir.

Example 17 Sunscreen cosmetics Using the monoester of the present invention, sunscreen cosmetics having the following formulation were prepared.

Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Cyclomethicone 22.0
Isododecane 10.0
Diethylaminohydroxybenzoyl hexyl benzoate 5.0
Ethylhexyl methoxycinnamate 5.0
(Dimethicone / Vinyl Dimethicone) Cross Polymer 5.0
(Vinyl dimethicone / methicone silsesquioxane) Cross polymer
5.0
Neosolue-EHS (Nippon Fine Chemical Co., Ltd.) 3.0
IPSE (Nippon Fine Chemical) 3.0
NS-408 (Nippon Fine Chemical Co., Ltd.) 3.0
Silicone treated zinc oxide 3.0
Silicone treated titanium oxide 3.0
Ethylhexyl methoxycinnamate 3.0
Octocrylene 3.0
Cetyldiglyceryltris (trimethylsiloxy) Cyrilethyldimethicone
1.0
Bisethylhexyloxyphenol methoxyphenyl triazine
1.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
PEG / PPG-19 / 19 dimethicone, cyclopentasiloxane
1.0
Neosolue-MP (Nippon Fine Chemical Co., Ltd.) 0.5
Compound 0.5 of Synthesis Example 1
Part B Ethanol 10.0
Glycerin 3.0
BG 9.0
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 0.5
VC Ethyl (Nippon Fine Chemical Co., Ltd.) 0.1
Na citrate, appropriate amount of citric acid Amount of water that makes a total of 100 -----------------------------------------------------------------------------
(Preparation method)
Parts A and B are heated and dissolved to uniformly disperse. Part B is gradually added to part A to emulsify. Cool with stirring.

Example 18 Foundation Using the monoester of the present invention, a foundation having the following formulation was prepared.

Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Phytosteryl isostearate (Plandol-ISS: Nippon Fine Chemical Co., Ltd.) 4.0
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 8.0
NS-408 (Nippon Fine Chemical Co., Ltd.) 5.0
Isopropyl myristate (Neosolve-IPM: Nippon Fine Chemical Co., Ltd.) 2.0
IOTG (Nippon Fine Chemical Co., Ltd.) A total amount of 100 isostearic acid 10.0
Compound 1.0 of Synthesis Example 1
Vaseline 0.2
Squalene 0.2
Dimethicone 3.0
Beeswax 21.0
Talc 10.0
Tocopherol 0.1
Titanium oxide 1.5
Yellow iron oxide 0.3
Bengala 0.03
Black iron oxide 0.03
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Each component was mixed, stirred at high speed, and mixed uniformly.

Example 19 Foundation Using the monoester of the present invention, a foundation having the following formulation was prepared.

Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Sunflower seed oil fatty acid phytosteryl (Plandol-SUN: Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 0.3
Cyclomethicone 3.5
Dimethicone (5cs) 2.0
Trimethylsiloxysilicic acid 1.5
Octyl methoxycinnamon 1.0
Compound 0.5 of Synthesis Example 1
Phenoxyethanol 0.4
Tocopherol 0.1
Ascorbyl palmitate 0.1
Amount of mica totaling 100 talc 24.0
Titanium oxide 20.0
Iron oxide 1.9
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Each component was mixed, stirred at high speed, and mixed uniformly.

Example 20 Solid powder foundation Using the monoester of the present invention, a solid powder foundation having the following formulation was prepared.

Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Plandoll-H (Nippon Fine Chemical Co., Ltd.) 2.0
Macadamia nut oil fatty acid cholesteryl (YOFCO MAC: Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG3 (Nippon Fine Chemical Co., Ltd.) 0.1
Di-lauroyl glutamate (octyldodecyl / phytosteryl / behenyl)
(Plandol-LG4: Nippon Fine Chemical Co., Ltd.) 0.1
Dimer dilinoleate di (isostearyl / phytosteryl)
(LUSPLAN PI-DA: Nippon Fine Chemical Co., Ltd.) 3.0
Cetyl ethylhexanoate (NS-CIO: Nippon Fine Chemical Co., Ltd.) 3.0
Mineral oil 1.6
Part B Lecithin-treated sericite 20.0
Boron Nitride 10.0
Compound 0.5 of Synthesis Example 1
Mica 3.0
Silica 2.0
Dimethicone 3.0
Nylon-12 3.0
Talc 10.0
Titanium oxide 10.0
Amount of iron oxide totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Heat and mix part A. Take part B in a separate container and mix and disperse. Add part A to part B and mix uniformly.

Example 21 Lip Gloss Using the monoester of the present invention, a lip gloss having the following formulation was prepared.

Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Triethylhexyl trimeritate 20.0
Glyceryl triethylhexanoate (IOTG: Nippon Fine Chemical Co., Ltd.) 3.0
Dimethylsilylated silica 3.2
Compound 0.1 of Synthesis Example 1
Methylparaben 0.1
BHT 0.01
Part B Diisostearyl malate Amount totaling 100 NS-408 (Nippon Fine Chemical Co., Ltd.) 15.0
Dextrin palmitate 1.0
Microcrystalline wax 1.0
Beeswax 1.0
Part C Ethylhexyl palmitate (Neosolue-IOP: Nippon Fine Chemical Co., Ltd.) 1.6
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 2.0
Dimer dilinoleic acid Dimer dilinoleil (LUSPLAN DD-DA7: Nippon Fine Chemical Co., Ltd.) 20.0
Shea butter 1.0
Iron oxide 0.1
Yellow 4 0.2
Titanium oxide 0.5
Red 202 0.03
Gunjo 0.1
Borosilicate (Ca / Al), titanium oxide, silica, tin oxide 2.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and dispersed. Part B was heated to about 120 ° C. and mixed uniformly. Part C was kneaded and made uniform, and part B and part A were mixed and made uniform.

Example 22 Mascara Using the monoester of the present invention, a mascara having the following formulation was produced.

Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Iron Oxide (Black) 10.0
Polyacrylic acid ester emulsion 30.0
Amount of purified water totaling 100 Part B Celesin 6.0
Beeswax 2.0
Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 0.5
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 0.5
Sorbitan sesquioleate 4.0
Compound 0.05 of Synthesis Example 1
Preservatives Appropriate amount Fragrance Appropriate amount Hydrogenated polyisobutene 30.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was dispersed with a homomixer and then heated to maintain 70 ° C. Part B was mixed and heated to keep at 70 ° C. Part A was added to part B and emulsified and dispersed uniformly with a homomixer to obtain the desired mascara.

Example 23 Eyeshadow Using the monoester of the present invention, an eyeshadow having the following formulation was produced.

Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A talc 10.0
Kaolin 2.0
Facial department 5.0
Compound 0.05 of Synthesis Example 1
Part B Plandool-ISS (Nippon Fine Chemical Co., Ltd.) 0.5
Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 0.5
Stearic acid 3.0
Neosolue-IPM (Nippon Fine Chemical Co., Ltd.) 5.0
Liquid paraffin 5.0
Propylene glycol monolaurate 3.0
BHT Appropriate amount C part BG 5.00
Glycerin 1.0
Methylparaben Appropriate amount Triethanolamine 1.20
EDTA-2Na 0.2
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was mixed with a blender and then treated with a crusher. Part C was heated and dissolved at 70 to 75 ° C. Part B was heated and dissolved at 70 to 80 ° C. (oil phase part). Part A was added to part C, and the mixture was stirred and mixed. Part B was added to this with stirring, dispersed by a homomixer, and stirred and cooled to room temperature to obtain the desired eye shadow.

Claims (2)

A cosmetic comprising a cyclohexanedicarboxylic acid selected from 1,2-cyclohexanedicarboxylic acid, 1,3-cyclohexanedicarboxylic acid and 1,4-cyclohexanedicarboxylic acid and a monoester of cholesterol. The cosmetic according to claim 1, wherein the cyclohexanedicarboxylic acid is a 1,2-cyclohexanedicarboxylic acid.