JP5521025B2 - Penetration enhancer - Google Patents

Description

The present invention relates to a hair cosmetic containing a diester of a dicarboxylic acid represented by Chemical Formula 1 and a polyoxyethylene monoalkyl ether represented by Chemical Formula 2 and a water-soluble active ingredient.
(Chemical formula 1)
HO-CO-R1-CO-OH
(Wherein R1 represents a linear, branched or cyclic hydrocarbon group having 2 to 10 carbon atoms)
(Chemical formula 2)
R2- (OCH2CH2) n-OH
(Wherein R2 is a linear, branched or cyclic hydrocarbon group having 1 to 12 carbon atoms, and n represents an integer of 2 to 11)

  Promoting the penetration of the active ingredient of the cosmetic or the external preparation for skin into the hair or skin is important for enhancing the effect of the active ingredient. Therefore, various penetration enhancers have been used conventionally. As such penetration enhancers, dimethyl sulfoxide, oleic acid, benzyl alcohol and the like are known. Further, dibasic acid lower alcohol diesters such as diethyl sebacate are also known to have penetration promoting effects. However, conventional penetration enhancers such as dimethyl sulfoxide, oleic acid, and benzyl alcohol have problems in safety such as skin irritation and skin sensitization or feeling of use, and are not always satisfactory. Although dibasic acid lower alcohol diesters such as diethyl sebacate are excellent in safety and usability, they have a problem that they are difficult to use for promoting penetration of water-soluble components because they are poor in water solubility.

  On the other hand, diesters of polyoxyethylene monoalkyl ether and dicarboxylic acid have both hydrophilic and lipophilic functions, and are known to have excellent usability and feel as oils for cosmetics or skin external preparations. . However, the penetration promotion effect was not known at all.

Chem. Pharm. Bull. , 36, 4, 1519-1528 (1988) Chem. Pharm. Bull. , 29, 2, 519-531 (1981) Chem. Pharm. Bull. , 29, 6, pp. 1708-1714 (1981)

JP 2005-206524 A Japanese Patent Application No. 2006-315081

  The problem to be solved by the present invention is hair having excellent penetration of an active ingredient, which has an excellent penetration promotion effect on hair, and further contains a penetration promoter having water solubility and a water-soluble active ingredient. It is to provide cosmetics.

As a result of intensive studies to solve the above problems, the present inventors have used the above-mentioned problems when a diester of a dicarboxylic acid represented by Chemical Formula 1 and a polyoxyethylene monoalkyl ether represented by Chemical Formula 2 is used. The inventors have found that this can be solved and completed the present invention.
That is, the present invention provides a hair cosmetic containing a penetration enhancer containing a diester of a dicarboxylic acid represented by Chemical Formula 1 and a polyoxyethylene monoalkyl ether represented by Chemical Formula 2 and a water-soluble active ingredient. To do.
(Chemical formula 1)
HO-CO-R1-CO-OH
(Wherein R1 represents a linear, branched or cyclic hydrocarbon group having 2 to 10 carbon atoms)
(Chemical formula 2)
R2- (OCH2CH2) n-OH
(Wherein R2 is a linear, branched or cyclic hydrocarbon group having 1 to 12 carbon atoms, and n represents an integer of 2 to 11)

  The penetration enhancer containing the diester of the present invention has an excellent penetration promoting effect on the hair of the active ingredient and also has water solubility, so it can be preferably blended into hair cosmetics. The effect of the active ingredient of hair cosmetics can be enhanced. Moreover, the usefulness of an active ingredient is improved by the effect of said penetration enhancer in the hair cosmetics of this invention.

In order to express the excellent function of the present invention, it is essential to use a diester of a dicarboxylic acid represented by Chemical Formula 1 and a polyoxyethylene monoalkyl ether represented by Chemical Formula 2.
(Chemical formula 1)
HO-CO-R1-CO-OH
(Wherein R1 represents a linear, branched or cyclic hydrocarbon group having 2 to 10 carbon atoms)
(Chemical formula 2)
R2- (OCH2CH2) n-OH
(Wherein R2 is a linear, branched or cyclic hydrocarbon group having 1 to 12 carbon atoms, and n represents an integer of 2 to 11)

  As the dicarboxylic acid represented by Chemical Formula 1 constituting the diester, R1 is a dicarboxylic acid representing a linear, branched or cyclic hydrocarbon group having 2 to 10 carbon atoms. Specifically, saturated linear dicarboxylic acids such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, dodecanedioic acid; 2,2,4-trimethyladipic acid, 2,4 Saturated branched dicarboxylic acids such as 1,4-trimethyladipic acid; cyclic such as 1,2-cyclohexanedicarboxylic acid, 1,3-cyclohexanedicarboxylic acid, 1,4-cyclohexanedicarboxylic acid, phthalic acid, isophthalic acid, terephthalic acid And the like. Of these, succinic acid, adipic acid, azelaic acid, sebacic acid, and dodecanedioic acid are preferable as the saturated linear dicarboxylic acid from the viewpoint of availability, economy, penetration promotion effect, and the like, and as the cyclic dicarboxylic acid, 1,4-cyclohexanedicarboxylic acid, phthalic acid, and terephthalic acid are preferred. Of these, succinic acid, adipic acid and 1,4-cyclohexanedicarboxylic acid are preferred, and 1,4-cyclohexanedicarboxylic acid is most preferred.

  On the other hand, as a polyoxyethylene monoalkyl ether represented by Chemical Formula 2 constituting a diester, R2 is a linear, branched or cyclic hydrocarbon group having 1 to 12 carbon atoms, and n is an integer of 2 to 11 It is. Examples of straight, branched or cyclic hydrocarbon groups having 1 to 12 carbon atoms include methyl group, ethyl group, propyl group, isopropyl group, n-butyl group, isobutyl group, n-pentyl group, and n-hexyl group. Cyclohexyl group, n-octyl group, 2-ethylhexyl group, n-decyl group, n-dodecyl group, and the like. From the reactivity during esterification, performance of diester, economy, etc., methyl group, ethyl Group is preferred, and ethyl group is particularly preferred. Furthermore, n is preferably 2 or 3 from the viewpoint of economy, reactivity, etc., and the polyoxyethylene monoalkyl ether represented by Chemical formula 2 is preferably diethylene glycol monoethyl ether or triethylene glycol monoethyl ether, and diethylene glycol Most preferred is monoethyl ether.

  Preferred compounds as diesters of the dicarboxylic acid represented by Chemical Formula 1 and the polyoxyethylene monoalkyl ether represented by Chemical Formula 2 used in the present invention are the above-mentioned preferred dicarboxylic acids and preferred polyoxyethylene monoalkyl ethers. Is a combination. Specifically, 1,4-cyclohexanedicarboxylic acid bis (diethylene glycol monoethyl ether) ester, 1,4-cyclohexanedicarboxylic acid bis (triethylene glycol monoethyl ether) ester, adipic acid bis (diethylene glycol monoethyl ether) ester Preferably, 1,4-cyclohexanedicarboxylic acid bis (diethylene glycol monoethyl ether) ester is most preferable.

  Although the manufacturing method of the diester used for this invention is not specifically limited, The esterification reaction is 150-260 degreeC by the following manufacturing methods, ie, the raw material dicarboxylic acid or dicarboxylic acid anhydride, and polyoxyethylene monoalkyl ether without a solvent. If it makes it, it can manufacture economically advantageous. The charging ratio of the dicarboxylic acid and the polyoxyethylene monoalkyl ether during the esterification reaction is preferably 1.6 to 6, more preferably 2 to 4 in molar ratio from the ester production rate and economical viewpoint. is there. Esterification can also be performed using a catalyst and a solvent. When a catalyst such as an acid catalyst is used, a general acid catalyst such as p-toluenesulfonic acid, sulfuric acid, hydrochloric acid, methanesulfonic acid, boron trifluoride diethyl ether complex, titanium alcoholate, or solid acid catalyst can be used. . When using a solvent, commonly used solvents such as toluene and heptane can be used. After completion of the esterification reaction, the target diester of the present invention can be obtained by purification without purification or by a conventional purification method such as vacuum distillation, washing with water, steam deodorization, activated carbon treatment or the like. During production, in addition to diesters, monoesters and unreacted polyoxyethylene monoalkyl ethers may remain in the diesters. Even if the monoester or unreacted polyoxyethylene monoalkyl ether remains, there is no problem in use, but the purity of the diester is 80% by weight or more, preferably 90% by weight or more, more preferably 95% by weight or more. It is desirable to be.

  The diester thus obtained has an excellent penetration promoting effect on the hair of the active ingredient and also has water solubility, so that it can be used as it is as a penetration promoter, but an antioxidant. And other moisturizers, feel improvers and the like for cosmetics or external preparations for skin. As the antioxidant, tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or a derivative thereof can be used. When the antioxidant is contained, the content of the antioxidant is preferably 0.0001 to 0.1% by weight. The content of the diester in the penetration enhancer of the present invention is not particularly limited, but is generally 0.1 to 99.99% by weight, preferably 50 to 99.99% by weight.

  Since the penetration enhancer of the present invention has an excellent penetration promoting effect on the hair of the active ingredient and also has water solubility, it can be preferably blended in hair cosmetics for the purpose of promoting penetration of the active ingredient. it can. The blending amount of the penetration enhancer of the present invention into the hair cosmetic composition is not particularly limited, but is preferably about 0.01 to 99% by weight, more preferably 0.1 to 50% by weight, and still more preferably 0.8% as a diester. 2 to 20% by weight.

  On the other hand, the hair cosmetic composition of the present invention contains the penetration enhancer of the present invention and a water-soluble active ingredient. By containing the penetration enhancer of the present invention and a water-soluble active ingredient, a hair cosmetic composition with improved permeability of the water-soluble active ingredient can be obtained. The blending amount of the penetration enhancer of the present invention into the hair cosmetic composition of the present invention is as described above. The water-soluble active ingredient to be contained in the hair cosmetic composition of the present invention is not particularly limited as long as it has sufficient water-solubility and is effective for hair, and specific examples include keratin-degrading peptides, Hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed Degraded silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat protein, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide and other protein peptides and their derivatives; palmitoyl oligopeptide, palmitoyl Acylated peptides such as glutamine, palmitoyltetrapeptide; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, asparagine Amino acids such as acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine and the like and salts and derivatives thereof; 18 -Methyl eicosanoate, branched fatty acid (12-31) salt, lanolin fatty acid salt, ethyl sulfate 18-methyleicosanoate aminopropylethyldimethylammonium, ethyl sulfate Long-chain branched fatty acid (12-31) 18-methyleicosanoic acid and anteiso fatty acid derivatives such as aminopropylethyldimethylammonium amino acid, lanolin fatty acid aminopropylethyldimethylammonium sulfate; water-soluble sphingolipids such as sugar ceramide; Vitamin Cs such as sodium salts; ascorbic acid alkyl ethers such as ascorbic acid ethyl ether; ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof; ascorbic acid phosphate sodium salts and ascorbic acid phosphates Ascorbic acid derivatives such as magnesium salt, palmitoyl ascorbic acid sodium phosphate, ascorbic acid phosphate such as tocopheryl phosphate ascorbyl; Hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide, and vitamin B group such as choline; pantothenic acid, panthenyl Other vitamins such as ethyl ether, panthenol, biotin; water-soluble vitamin Es such as tocopherol phosphate; hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; kojic acid, ellagic acid salt, tranexamic acid Salts and derivatives thereof, ferulates and derivatives thereof, placenta extract, glutathione, glycyrrhizic acid and derivatives thereof, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, cafe Derivatives such as in, α-lipoic acid, rutin and glycosides; derivatives such as hesperidin and glycosides; and various plant extracts such as Nishikawayanagi extract. The blending amount of the water-soluble active ingredient in the hair cosmetic composition of the present invention is generally 0.01 to 10% by weight, although it varies depending on the type of the active ingredient.

  In addition, the hair cosmetic composition of the present invention contains additives that are generally blended into the hair cosmetic composition as necessary, for example, an oily base, a moisturizer, a touch improver, a surfactant, a polymer, a thickening agent, Gelling agent, solvent, propellant, antioxidant, reducing agent, oxidizing agent, antiseptic, antibacterial agent, chelating agent, pH adjuster, acid, alkali, powder, inorganic salt, UV absorber, whitening agent, vitamin And derivatives thereof, anti-inflammatory agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, squeeze agents, cooling agents, warming agents, wound healing promoters , Stimulants, pain relievers, cell activators, plant / animal / microbe extracts, antipruritics, exfoliating / dissolving agents, antiperspirants, refreshing agents, astringents, enzymes, nucleic acids, fragrances, pigments, colorants, dye , Pigments, water and the like can be blended.

  Examples of these additive components include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, seraalkyl alcohol, batyl. Higher alcohols such as alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylen Acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, ethyl Higher fatty acids such as cosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. Metal soaps, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene , Hydrocarbons such as petroleum jelly and solid paraffin; candelilla wax, carnauba wax, rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax , Petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene / propylene copolymer and other waxes; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, Wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, mint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil Vegetable oils such as peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle Animal fats and oils such as oil; animal oils such as whale wax, lanolin and orange luffy oil Liquid lanolin, reduced lanolin, adsorption purified lanolin, lanolin acetate, acetic acid liquid lanolin, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester, etc. Lanolins: phospholipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phosphatidic acid, lysolecithin, etc .; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid , Phospholipid derivatives such as hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid; cholesterol, dihydrocholesterol, lanosterol, dihi Sterols such as loranosterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / Octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl) Acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, Steroid esters such as macadamia nut oil fatty acid phytosteryl, isostearate phytosteryl, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / phytosterol complex Lipid complexes such as octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononanoyl isononanoate, isononanoic acid Octyl, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, neopentanoic acid Stearyl, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, avocado oil fatty acid Ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate , Monoalcohol carboxylic acid esters such as triethyl citrate; cetyl lactate, dii malate Oxyacid esters such as sostearyl, monoisostearic acid hydrogenated castor oil; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / caprin) Acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, dioctanoic acid Neopentyl glycol, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate Pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearic acid / sebacic acid), pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / rosin acid) Dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate ( Ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopentanoate, 2, dineopentanoic acid 2, Polyhydric alcohol fatty acid esters such as diethyl-1,5-pentanediol; diisopropyl dimerlinoleate, diisostearyl dimerdilinoleate, dimerdilinoleate di (isostearyl / phytosteryl), dimerdilinoleic acid (phytosteryl) / Behenyl), dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearic dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinol Dimer acid or dimer diol derivative such as acid-hardened castor oil, hydroxyalkyl dimer linoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanola Amide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide ( Fatty acid alkanolamides such as partamide DEA) and palm oil fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopenta) Siloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylamino) (Ropylemethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicone such as dimethicone copolyol, polyglycerin-modified silicone, sugar Modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone, peptide modified silicone, fluorine modified silicone, cation modified and polyether modified silicone, Amino- and polyether-modified silicones, alkyl- and polyether-modified silicones, Silicones such as hexane-polyoxyalkylene copolymer; perfluorodecane, perfluorooctane, fluorine-based oils such as perfluoropolyether may be mentioned as preferred.

  As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosandioic acid / tetradecandioic acid) water-soluble esters such as polyglyceryl-10 and tetradecandioic acid polyglyceryl-10; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol; glucose, fructose, galactose Mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and maltosylation, Modified cyclodextrins such as hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen Sugars such as ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer, and derivatives thereof; hyaluronic acid, sodium hyaluronate; chondroitin sulfate sodium; mucoitin sulfate, caroline sulfate, kerato sulfate, dermatan sulfate; white jellyfish extract, white jellyfish Fucoidan; Tuberose polysaccharide, naturally-occurring polysaccharide; Organic acids such as citric acid, tartaric acid and lactic acid and salts thereof; Urea; 2-pyrrolidone-5-carboxylic acid and salts thereof such as sodium; Betaine (trimethylglycine) , Proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methio , Leucine, isoleucine, valine, tryptophan, histidine, taurine and other amino acids and salts thereof; keratin-degrading peptide, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, hydrolyzed collagen, chloride Hydroxypropylammonium hydrolyzed collagen, elastin degrading peptide, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat protein, wheat proteolytic peptide, hydrolyzed wheat Protein peptides such as proteins and casein-degrading peptides and their derivatives; such as palmitoyl oligopeptides, palmitoyl pentapeptides, palmitoyl tetrapeptides, etc. Acylated peptides; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular mucin, hypotaurine, sesameignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placental extract , Aerustin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, Achillea millefolium extract, eucalyptus extract, merirot extract, etc., natural type Preferred examples include ceramides such as ceramide (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide and sugar-ceramide-containing extract.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium minate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonate; alkylsulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and tetraethanolamine tetraethanol; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laurethrin Alkyl ether phosphates such as sodium, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide ether phosphorus Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants, laureth (Polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez (polyoxyethylene) Nbehenyl ethers), isosteares (polyoxyethylene isostearyl ethers), octyldecesses (polyoxyethylene octyldodecyl ethers) and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, poly Castor oil such as oxyethylene hydrogenated castor oil maleic acid and hydrogenated castor oil derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxy Polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene polyoxypropylene monobutyl ether, polyoxyethylene lanolin; Oxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, myristate group Glyceryl fatty acid partial esters such as ceryl, glyceryl oleate, glyceryl coconut fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, α, α'-oleic acid pyroglutamic acid glycerin, monostearic acid glycerin malic acid; Polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, polyglyceryl isostearate -2, 3, 4, 5, 6, 8, 10, diglycostyl diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl tetraisostearate Ril-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3,4, 5,6, 8,8, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol moieties Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monos Sorbitan fatty acid esters such as allate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside fatty acid ester, trehalose undecylenate, etc. Partial derivatives of sugar derivatives; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohols; reduced lanolin; polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene di- Polyoxyethylene fatty acid mono- and diesters such as oleate; polyoxyethylene propylene glycol fatty acid ester; polyoxyethylene Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as polyglycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxy Polyoxyethylene sorbitan fatty acid esters such as ethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol penta Polyoxyethylene sorbitol fatty acid esters such as oleate and polyoxyethylene sorbitol monostearate Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; Alkyl such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, batyl alcohol Glyceryl ethers; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil Fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (laura) De MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methyl ethanolamide (cocamidomethyl) Fatty acid alkanolamides such as MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; poly such as dimethicone copolyol Silicone such as ether-modified silicone, polysiloxane-oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone Nonionic surfactants, etc .; for cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; alkyls such as stearyltrimonium bromide Trialkylammonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ether amines such as stearoxypropyldimethylamine; Salt or quaternary salt thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl lanolin sulfate Fatty acid amide-type quaternary ammonium salts such as aminopropylethyldimethylammonium fatty acid; polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzalkonium salt; Pyridinium salt such as cetylpyridinium chloride; Imidazolinium salt; Alkylisoquinolinium salt; Dialkyl morpholinium salt; Polyamine fatty acid derivatives; Aminopropyl dimethicone and amodimethicone Silicone-based cationic surfactants such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, etc .; amphoteric Surfactants include N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N, N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine. Imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanolphosphate; phosphatidylcholine , Phosphatidylethanolamine, phosphatidylserine, sphingomyelin and other sphingophospholipids, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean Phospholipids such as phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, and hydroxylated lecithin; silicone-based amphoteric surfactants; polymer surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum , Acrylic acid / methacrylic acid alkyl copolymer; and various silicone-based surfactants.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, Chitin, chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypro Cellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch , Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinic acid corn starch aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA) , Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ester Ter; polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymers; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; poly Acrylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquatani -47 and other acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer, chloromethacrylic acid choline ester polymer; cationized polysaccharide such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride ; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacryl alkyl ester emulsion , Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride , Fumed silica (ultrafine silica), magnesium magnesium silicate, sodium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester Is preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Preservatives and antibacterial agents include hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben, and butylparaben and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-pentanediol, 1,2-hexane 1,2-diols such as diols; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides , Quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, Kichioru; phenol, isopropyl phenol, cresol, thymol, p-chlorophenol, phenylphenol, other phenols such as phenylphenol sodium; phenylethyl alcohol, photosensitive Motorui, be mentioned as antibacterial zeolite, silver ion. Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

  Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid-based UV absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone purple 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphsulfone Preference is given to acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

  Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbate phosphate and magnesium ascorbate phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylreso Shinoru, oil-soluble Kamomiraekisu, oil-soluble licorice extract, Nishikawa willow extract, be mentioned as saxifrage extract, and the like plant extracts are preferred.

  Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin E such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid, panthenyl ethyl ether, panthenol, biotin; ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium Ascorbic acid phosphate ester salts such as ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl fatty acid esters such as ascorbyl, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid- Ascorbic acid glucosides such as 2-glucoside and fatty acid esters thereof, ascorbic acid derivatives such as tocopheryl phosphate ascorbyl; vitamins such as tocopherol derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, ferulic acid tocopherol and tocopherol phosphate Derivatives, tocotrienols, and other various vitamin derivatives are preferred.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

  As plant / animal / microbe extracts, Iris extract, Ashitaba extract, Asunaro extract, Asparagus extract, Avocado extract, Achacha extract, Almond extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Ginkgo biloba extract, Ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.

As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Base dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4- hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-
phenylenediamine, HC Blue 2, Basic
Nitro dyes such as Blue 26; Disperse dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic red pigments such as iron oxide (Bengara) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Yellow oxidation Inorganic yellow pigments such as iron and ocher; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic such as chromium oxide, chromium hydroxide and cobalt titanate Green pigments; inorganic blue pigments such as ultramarine and bitumen; pearl pigments such as titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil; aluminum powder Metal powder pigments such as copper powder and gold; surface-treated inorganic and metal powder pigments; red 201, red 202, Color No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red 104 No., Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1, etc. Organic pigments such as zirconium, barium or aluminum lakes; surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin Naphthoquinones, bixins, flavones, betacyanidine, Natural pigments / dyes such as hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2 -Oxidative dye intermediates and couplers such as methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; auto-oxidizing dyes such as indoline; and dihydroxyacetone are preferred.

  Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  The hair cosmetic composition of the present invention can be produced according to a usual method.

  The types of hair cosmetics of the present invention will be described in more detail. Examples of hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, rinse-integrated shampoos, etc .; Treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow, split hair coat, hair oil, Permanent Wave Agent, Straight Perm Agent, Oxidative Hair Dye, Hair Bleach, Hair Color Pretreatment, Hair Color After Treatment, Perm Pre Treatment, Perm After Tree Instruments, hair manicure, and as hair growth agents are preferred.

  Examples of the dosage form of the hair cosmetic of the present invention include aqueous liquid cosmetics, oil-in-water (O / W) types, water-in-oil (W / O) types, W / O / W types, O / W / O types, and the like. Emulsified cosmetics, oily cosmetics, solid cosmetics, kneaded cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, paste cosmetics Examples of preferable dosage forms include emulsion polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example, this invention is not limited to these Examples.

Example 1 Synthesis of 1,4-cyclohexanedicarboxylic acid bis (diethylene glycol monoethyl ether) ester and preparation of a penetration enhancer composition containing the same 1 in a 3 L reactor equipped with a stirrer, thermometer and gas introduction pipe , 4-cyclohexanedicarboxylic acid 602 g (3.5 mol) and diethylene glycol monoethyl ether 1503 g (11.2 mol) were charged, heated to 150 ° C. to 230 ° C. while blowing nitrogen, and reacted for 33 hours while distilling off water. I let you. Subsequently, unreacted diethylene glycol monoethyl ether was distilled off under reduced pressure, and steam deodorization was performed to obtain 1358 g (yield 96%) of the desired 1,4-cyclohexanedicarboxylic acid bis (diethylene glycol monoethyl ether) ester. The obtained ester was a colorless to pale yellow liquid having an acid value of 3.3 and a hue Gardner of 1 or less. The diester content was 99% from analysis by capillary gas chromatography (FID, area percentage). By adding 0.03% by weight of δ-d-tocopherol to the obtained 1,4-cyclohexanedicarboxylic acid bis (diethylene glycol monoethyl ether) ester, stirring and mixing, the penetration enhancer composition 1 (1,4 -Permeation accelerator composition of 99.97% by weight of bis (diethylene glycol monoethyl ether) ester of cyclohexanedicarboxylic acid and 0.03% by weight of δ-d-tocopherol) was obtained.

Example 2 Synthesis of 1,4-cyclohexanedicarboxylic acid bis (triethylene glycol monoethyl ether) ester and preparation of penetration enhancer composition containing the same 300 mL reactor equipped with stirrer, thermometer and gas introduction pipe 1,4-cyclohexanedicarboxylic acid 55 g (0.32 mol) and triethylene glycol monoethyl ether 112 g (0.64 mol) were charged, heated to 150 ° C. to 250 ° C. while blowing nitrogen, and water was distilled off. The reaction was carried out for 30 hours, and steam deodorization was carried out to obtain 140 g (yield 92%) of the desired 1,4-cyclohexanedicarboxylic acid bis (triethylene glycol monoethyl ether) ester. The ester obtained was a pale yellow liquid with an acid value of 7.7 and a hue Gardner 3. The diester content was 90% from analysis by capillary gas chromatography (FID, area percentage). By adding 0.03% by weight of δ-d-tocopherol to the resulting 1,4-cyclohexanedicarboxylic acid bis (triethylene glycol monoethyl ether) ester, stirring and mixing, the penetration enhancer composition 2 (1 , 4-cyclohexanedicarboxylic acid bis (triethylene glycol monoethyl ether) ester 99.97 wt%, δ-d-tocopherol 0.03% wt penetration penetration enhancer composition).

Example 3 Synthesis of bis (diethylene glycol monoethyl ether) ester of adipic acid and preparation of penetration enhancer composition containing the same 75 g of adipic acid (0.3 g) in a 300 mL reactor equipped with a stirrer, thermometer and gas introduction tube. 5 mol) and 206.3 g (1.5 mol) of diethylene glycol monoethyl ether were charged, heated to 150 ° C. to 230 ° C. while blowing nitrogen, and reacted for 27 hours while distilling off water. Subsequently, unreacted diethylene glycol monoethyl ether was distilled off under reduced pressure and steam deodorization was performed to obtain 185 g (yield 96%) of the target diester. The obtained ester was a colorless to pale yellow liquid having an acid value of 4.0 and a hue Gardner of 1 or less. The diester content was 99% from analysis by capillary gas chromatography (FID, area percentage). By adding 0.03% by weight of δ-d-tocopherol to the obtained diester, stirring and mixing, the penetration enhancer composition 3 (99.97% by weight of bis (diethylene glycol monoethyl ether) ester adipate, δ -D-tocopherol 0.03% by weight penetration enhancer composition).

Example 4 Synthesis of succinic acid bis (diethylene glycol monoethyl ether) ester and preparation of penetration enhancer composition containing the same 90.0 g of succinic anhydride in a 300 mL reactor equipped with a stirrer, thermometer and gas introduction tube (0.9 mol) and 362.1 g (2.7 mol) of diethylene glycol monoethyl ether were charged, heated to 150 ° C. to 230 ° C. while blowing nitrogen, and reacted for 20 hours while distilling off water. Subsequently, unreacted diethylene glycol monoethyl ether was distilled off under reduced pressure and steam deodorization was performed to obtain 297 g (yield 94%) of the target diester. The obtained ester was a colorless to pale yellow liquid having an acid value of 3.4 and a hue Gardner of 1 or less. The diester content was 99% from analysis by capillary gas chromatography (FID, area percentage). By adding 0.03% by weight of δ-d-tocopherol to the obtained diester, stirring and mixing, the penetration enhancer composition 4 (99.97% by weight of bis (diethylene glycol monoethyl ether) succinate), δ -D-tocopherol 0.03% by weight penetration enhancer composition).

Example 5 Water solubility The solubility of the penetration enhancer compositions 1 to 4 of the present invention obtained in Examples 1 to 4 and diethyl sebacate in water was evaluated. The water solubility was evaluated by adding 2% by weight of each ester to water, stirring at 25 ° C., and visually confirming the appearance. As a result, it was confirmed that each of the penetration enhancer compositions of the present invention obtained in Examples 1 to 4 has a water solubility of 2% by weight or more. On the other hand, diethyl sebacate did not dissolve in water at all.

Examples 6 to 14 and Comparative Examples 1 to 8 Evaluation of hair cosmetics and hair penetration promoting effect (hair damage improving effect) Using the penetration promoter composition of the present invention obtained in Examples 1 to 4, 1 (Table 1-1, Table 1-2) was prepared by a conventional method. In addition, as a comparative control (comparative example), hair cosmetics having the compositions shown in Table 1 were prepared by a conventional method. Healthy black hair was subjected to permanent treatment once with a commercially available permanent wave treating agent and twice with a commercially available two-component oxidized bleaching agent to produce 17 bundles of 50 damaged hairs. These hair bundles were immersed in 50 g of each hair cosmetic composition of Examples 6 to 14 and Comparative Examples 1 to 8, treated at 37 ° C. for 30 minutes, washed with water and dried. After leaving at room temperature of 25 ° C. and humidity of 45% for 39 hours, 20 hairs were collected and the hair breaking strength was measured with a pulling tester (Rheometer / Fudo Kogyo Co., Ltd.). The measurement results are shown in the lower part of Table 1 as relative strength when the hair strength of undamaged hair (normal hair) is taken as 100.

  As shown in Table 1, a hair cosmetic containing a penetration enhancer 1 to 4 containing the diester of the present invention and hydrolyzed keratin, hydrolyzed wheat protein, hydrophobized hydrolyzed collagen, or pantothenyl ethyl ether (implementation) It was confirmed that Examples 6 to 14) had a higher effect of recovering the hair breaking strength than the hair cosmetics (Comparative Examples 1 to 7) not containing the penetration enhancer of the present invention. In addition, it was speculated that the penetration enhancer of the present invention promoted the penetration of active ingredients such as hydrolyzed keratin into the hair.

Example 15 Hair Essence without Washing out A hair essence having the following formulation was prepared. When this hair essence was applied to the hair, the hydrolyzed keratin penetrated into the hair, and the hair slipped, cohered, touched, moistened, and smooth on the hair surface.

Component Blending amount (% by weight)
--------------------------------
Penetration enhancing composition of Example 1 2.0
Hydrolyzed keratin aqueous solution (number average molecular weight 400, evaporation residue concentration 25%)
2.0
Cetrimonium chloride (25%) 0.6
Glycerin 5.0
Phenoxyethanol 0.2
Polyquaternium-6 0.8
Betaine 0.8
Ethanol 20.0
Purified water Total amount of 100 --------------------------------
(Preparation method)
Dissolve all ingredients uniformly.

Example 16 Non-washing hair treatment A non-washing hair treatment of the following formulation was prepared. When this hair treatment was applied to the hair, the hydrolyzed wheat protein penetrated into the hair, and the slipping, gathering, fingering, moist feeling, and smoothness of the hair surface were improved.

Component Blending amount (% by weight)
--------------------------------
Part A Penetration promoting composition of Example 1 2.0
Hydrolyzed wheat protein aqueous solution (number average molecular weight 700, evaporation residue concentration 20%)
2.0
Cetrimonium chloride (25%) 3.8
Caprylyl glucoside (50%) 0.8
Glycerin 4.0
Phenoxyethanol 0.2
Part B Ethanol 20.0
Part C Polyquaternium-6 0.6
Polyquaternium-7 0.4
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part C is heated to about 80 ° C. and dissolved. A part A is added to this, and it is made to melt | dissolve uniformly and it is made to cool to about 40 degreeC. Next, part B is added and mixed uniformly.

Example 17 Moist Charge Water A moist charge water having the following formulation was prepared. When this moist charge water was sprayed on the hair, the slip and unity improved, and a moist feeling could be imparted.
Component Blending amount (% by weight)
--------------------------------
Part A Penetration promoting composition of Example 1 5.0
Hydrolyzed keratin aqueous solution (number average molecular weight 400, evaporation residue concentration 25%)
1.0
Pentylene glycol 2.0
Phenoxyethanol 0.2
Stearyl trimonium chloride (64%) 4.6
Caprylyl glucoside (50%) 1.0
Dicocodimonium chloride (74%) 0.8
Lauramide DEA 1.0
PEG-60 hydrogenated castor oil 0.8
Part B Castor oil 0.2
Ethanol 20.0
Part C Polyquaternium-10 0.2
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part C is heated to about 80 ° C. and dissolved. A part A is added to this, and it is made to melt | dissolve uniformly and it is made to cool to about 40 degreeC. Next, part B is added and mixed uniformly.

Example 18 Restoration of bedclothes A bedclothing of the following formulation was prepared. By applying it to the hair, slipping and cohesion improved, and a moist feeling and suppleness could be imparted.

Component Blending amount (% by weight)
--------------------------------
Penetration enhancing composition of Example 1 5.0
Hydrolyzed keratin aqueous solution (number average molecular weight 1000, evaporation residue concentration 25%)
1.0
Glycerin 2.0
Pentylene glycol 2.0
Behentrimonium chloride (80%) 0.6
Ethanol 20.0
Dimethicone propyl betaine 1.0
Purified water Total amount of 100 --------------------------------
(Preparation method)
Dissolve all ingredients uniformly.

Example 19 Hair Lotion A hair lotion having the following formulation was prepared. By applying this hair lotion, the refreshing feeling of menthol was maintained and the scalp was kept healthy.

Component Blending amount (% by weight)
--------------------------------
Part A Penetration promoting composition of Example 1 2.0
Menthol 0.05
Ethanol 50.0
Part B Pyridoxine HCl 0.1
Glycyrrhizic acid 2K 0.1
BG 3.0
Panthenol 2.0
Purified water Total amount of 100 --------------------------------
(Preparation method)
A part Each component is mixed (A part). , B part Each component is mixed (B part). Add part B to part A and mix evenly.

Example 20 Preperm Liquid A preperm liquid having the following formulation was prepared. This pre-perm liquid can be applied to the hair before the permanent treatment, so that hair damage can be suppressed, the perm can be applied, and the holding can be improved.

Component Blending amount (% by weight)
--------------------------------
Penetration enhancing composition of Example 1 2.0
Cationic NH (Nippon Seika) 0.8
Hydrolyzed keratin aqueous solution (number average molecular weight 400, evaporation residue concentration 25%)
0.5
Caprylyl glucoside (50%) 1.0
PolySugaSil C-35P (Nippon Seika) 0.5
Citric acid appropriate amount Na citrate appropriate amount methylparaben 0.2
Purified water Total amount of 100 --------------------------------
(Preparation method)
Dissolve all ingredients uniformly.

Example 21 Shampoo A shampoo having the following formulation was prepared. This shampoo was not sticky, gave a moist feeling to the hair, and was able to give a smooth fingering.

Component Blending amount (% by weight)
--------------------------------
Part A Laureth sulfate Na (27%) 30.00
Cocamidopropyl betaine 10.00
Lauramide MIPA 1.00
PPG-2 cocamide 1.50
Methyl isothiazolinone 0.10
Penetration enhancing composition of Example 1 3.00
Part B Hydrolyzed keratin aqueous solution (number average molecular weight 400, evaporation residue concentration 25%)
1.00
Polyquaternium-10 0.20
Purified water Amount of part C totaling 100 parts Glycolic acid (50%) Suitable amount -----------------------------
(Preparation method)
Take part A and part B, heat to about 80 ° C., and mix uniformly. Add part A to part B, mix uniformly, and then cool (part D). Add part C to part D and adjust pH to 6-7.

Example 22 Treatment A treatment having the following formulation was prepared. This treatment was able to improve the hair damage feeling and give the hair a moist and soft feeling.

Component Blending amount (% by weight)
--------------------------------
Part A Behentrimonium chloride (80%) 2.40
Cetanol 5.20
Glyceryl stearate 1.20
LUSPLAN DAR 0.40
Dimethicone 2.00
(Aminoethylaminopropyl methicone / dimethicone)
Copolymer 0.50
Penetration enhancing composition of Example 1 1.60
Part B Hydrolyzed keratin aqueous solution (number average molecular weight 400, evaporation residue concentration 25%)
2.00
Methylparaben 0.10
Propylparaben 0.20
Purified water Total amount of 100 parts C Adenosine monophosphate (10%) Appropriate amount ------------------------------ −−
(Preparation method)
Take part A and part B, heat to about 80 ° C., and mix uniformly. The part B is gradually added to the part A with stirring and mixed uniformly, and then cooled (part D). Add part C to part D and adjust the pH to 5.2-5.7.

Example 23 Conditioner A conditioner having the following formulation was prepared. This conditioner was able to improve the hair damage feeling and give the hair a moist and soft feeling.

Component Blending amount (% by weight)
--------------------------------
Part A Cetanol 7.00
Glycerin 8.00
Behentrimonium chloride (80%) 2.80
Glyceryl stearate 0.20
Dicocodimonium chloride 0.20
Penetration enhancing composition of Example 1 1.00
Part B Hydrolyzed wheat protein aqueous solution (number average molecular weight 700, evaporation residue concentration 20%)
2.00
Phenoxyethanol 0.40
Purified water Amount to be 100 in total C part Citric acid (10%) Appropriate amount -------------------------------
(Preparation method)
Take part A and part B, heat to about 80 ° C., and mix uniformly. The part B is gradually added to the part A with stirring and mixed uniformly, and then cooled (part D). Add part C to part D and adjust pH to 4-5.

Example 24 Hair Cream A hair cream having the following formulation was prepared. This hair cream was not sticky, had good adhesion to the hair, was excellent in a set hair bundle feeling, and improved the hair damage feeling.

Component Blending amount (% by weight)
--------------------------------
Part A Cetanol 8.00
BEHENETH-2 2.00
BEHENETH-20 1.00
Methylparaben 0.20
Phenoxyethanol 0.40
Penetration enhancing composition of Example 1 0.50
Part B Hydrolyzed wheat protein aqueous solution (number average molecular weight 700, evaporation residue concentration 20%)
2.00
Polyquaternium-10 0.60
Ethanol (95%) 20.00
Purified water Total amount of 100 --------------------------------
(Preparation method)
Take part A and part B, heat to about 80 ° C., and mix uniformly. The part B is gradually added to the part A while stirring, and the mixture is uniformly mixed and then cooled.

Example 25 Hair wax A hair wax having the following formulation was prepared. This hair wax was not sticky, had good adhesion to the hair, and was excellent in set hair bundle feeling. Moreover, by continuing to use it, the damage feeling of hair was suppressed.

Component Blending amount (% by weight)
--------------------------------
Part A Microcrystalline wax 12.00
Triethylhexanoin 5.00
Candelilla Row 6.00
Hydroxystearic acid 4.00
Glyceryl stearate (Rheidol MS-60) 1.00
Glyceryl stearate (Nikkor MGS-BSE) 1.00
Behenez-2 4.00
BEHENETH-20 10.00
Phenoxyethanol 0.60
Methylparaben 0.20
BG 3.00
Penetration enhancing composition of Example 1 6.00
Part B Hydrolyzed keratin aqueous solution (number average molecular weight 400, evaporation residue concentration 25%)
0.50
Alcox Z-240 (Meisei Chemical) 0.20
Purified water Amount C in a total of 100 parts Citric acid (1%) Suitable amount Nacitrate Na (1%) Suitable amount ------------------------ ---------
(Preparation method)
Take part A and part B, heat to about 80 ° C., and mix uniformly. The part B is gradually added to the part A with stirring and mixed uniformly, and then cooled (part D). Adjust the pH to 6 by adding part C to part D.

Example 26 Straight Perm Agent (Cation Type)
One part and two parts of a straight perm agent (cation type) having the following formulation were prepared. This straight perm solution is a straight perm solution that can be applied to the straight perm firmly because it has high adhesion to hair and has a setting power.

(1 liquid)
Component Blending amount (% by weight)
--------------------------------
1 Penetration enhancing composition of Example 1 0.50
2 Cetanol 5.00
3 Steartrimonium chloride (63%) 2.40
4 Seths-20 2.40
5 TRIBEHENIN PEG-20 ESTERS 2.00
6 Seths-6 0.80
7 Lauramide MIPA 0.80
8 PEG-60 hydrogenated castor oil 0.40
9 Ammonium thioglycolate solution (50%) 13.50
10 Monoethanolamine 1.70
11 Polyquaternium-6 1.30
12 Hydrolyzed soy protein 1.00
13 EDTA-4Na 0.10
14 Ammonia water (28%) 1.10
15 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. Most of 15 were heated to about 80 ° C. (Part A). No. in a separate container. 1-8 were added and it heated and dissolved (part B). No. in a separate container. No.15, no. 9 to 13 were added and dissolved uniformly (part C). Part B was added to part A, mixed and stirred, and part C was added at about 45 ° C. and mixed uniformly. After cooling to room temperature, no. 14 was added.

(2 liquids)
Component Blending amount (% by weight)
--------------------------------
1 Penetration promoting composition of Example 1 2.00
2 Cetanol 5.00
3 Emmacol VT-20 (Sanei Chemical) 5.00
4 Dimethicone (200cs) 2.00
5 Trioctanoin 2.00
6 Octyldodecanol 0.60
7 Seths-20 0.50
8 Diammonium phosphate 0.20
9 Sodium benzoate 0.15
10 Hydrolyzed keratin 0.50
11 Na bromate 8.00
12 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. 1-7 were added, it heated at about 70 degreeC, and it was made to melt | dissolve (A part). No. in a separate container. No. 12 was taken and heated to about 70 ° C. 8-10 were added and dissolved (part B). No. in a separate container. Take the remainder of 12 and heat to about 60 ° C. 11 was added and dissolved (part C). At about 70 ° C., part B was added to part A and stirred until the viscosity increased. The mixture was cooled to 60 ° C., and part C was added with stirring and mixed uniformly. After the temperature dropped to about 50 ° C., it was rapidly cooled.

Example 27 Hair depigmenting agent (2 agent type)
A hair bleaching agent (two-part formulation) having the following formulation was prepared. This depigmenting agent (two-component type) is a depigmenting agent that reduces the sense of hair damage after depigmentation and gives the hair a good feel such as flexibility, moistness, and slipping. there were.

(1 agent)
Component Blending amount (% by weight)
--------------------------------
1 Penetration enhancing composition of Example 1 0.50
2 Polyoxyethylene oleyl ether 52.00
3 Ammonia water (25%) 25.50
4 Cetrimonium chloride (30%) 10.00
5 Ethanol 10.00
6 Purified water Total amount of 100 --------------------------------
(Preparation method)
Each component was stirred and mixed uniformly.

(2 agents)
Component Blending amount (% by weight)
--------------------------------
1 Hydrogen peroxide solution 17.00
2 Cetrimonium chloride (30%) 10.00
3 Cetanol 3.00
4 Seths-2 1.00
5 Seths-20 1.00
6 Na pyrophosphate 0.10
7 Diethylenetriaminepentaacetic acid 0.10
8 Citric acid (50%) appropriate amount
9 Purified water Total amount of 100 --------------------------------
(Preparation method)
Each component was mixed uniformly, and the pH was adjusted to 3.5 to 4.0 with citric acid.
(Mixing ratio)
1 agent: 2 agents = 1: 7

Example 28 Oxidative hair dye An oxidative hair dye having the following formulation was prepared. This oxidative hair dye is an oxidative hair dye that reduces the feeling of hair damage after hair dyeing and gives the hair a good feel such as flexibility, moist feeling, and slipperiness. It was.

(1 agent)
Component Blending amount (% by weight)
--------------------------------
1 Penetration enhancing composition of Example 1 0.50
2 Cationic NH (Nippon Seika) 1.00
3 Cetrinium chloride (25%) 23.00
4 Cetanol 9.00
5 Octild decanol 9.00
6 Monoethanolamine 3.80
7 Ammonia water 2.00
8 Myristyl sulfate Na 1.50
9 Ores-20 1.40
10 Toluene-2,5-diamine hydrochloride 1.00
11 Resorcin 1.00
12 Metaaminophenol 0.50
13 Paraaminophenol 0.20
14 Orthoaminophenol 0.10
15 Ascorbic acid 0.20
16 Fragrance 0.10
17 Purified water Total amount of 100 --------------------------------
(Preparation method)
Each component was mixed uniformly.

(2 agents)
Component Blending amount (% by weight)
--------------------------------
1 Hydrogen peroxide solution 17.00
2 Cetrinium chloride (30%) 10.00
3 Cetanol 3.00
4 Seths-2 1.00
5 Seths-20 1.00
6 Na pyrophosphate 0.10
7 Diethylenetriaminepentaacetic acid 0.10
8 Citric acid (50%) appropriate amount
9 Purified water Total amount of 100 --------------------------------
(Preparation method)
Each component was mixed uniformly, and the pH was adjusted to 3.5 to 4.0 with citric acid.
(Mixing ratio)
1 agent: 2 agents = 1: 1

Example 29 Curling Agent A curling agent having the following formulation was produced. By using the curl agent 1 and 2 produced in this way for the hair, it was possible to curl with good flexibility, slipperiness, moist texture, and good finish.

(1 liquid)
Component Blending amount (% by weight)
---------------------------------
1 Cysteamine hydrochloride 2.00
2 DL cysteine 0.40
3 Monoethanolamine 0.90
4 Ammonia water (28%) 0.50
5 POE20 palm oil fatty acid sorbitan 0.50
6 Fragrance 0.10
7 Diallylammonium chloride / acrylic acid copolymer 1.00
8 Emmacol VT-20 (Sanei Chemical) 3.00
9 Ores-20 0.50
10 Ores-50 0.20
11 Penetration enhancing composition of Example 1 0.50
12 Lanolin fatty acid octyldodecyl 0.30
13 Sorbitan monostearate 0.20
14 tetrasodium edetate tetrahydrate 0.10
15 Ammonium phosphate 0.50
16 Purified water Total amount of 100 ---------------------------------
(Preparation method)
No. No. 16 in part (20%) 1 to 3 was added and dissolved, and No. 1 was previously stored in another container. No. 16 in part (10%) What was melt | dissolved by adding 14 and 15 was added at about 40 degreeC, and it was made to melt | dissolve uniformly (part A). In another container, no. The remainder of 16 was warmed to about 75 ° C. (Part B). In another container 8-13 were taken and heated to about 75 ° C. to dissolve (Part C). After adding part B to part C and emulsifying and stirring and mixing well, it was cooled to 40 ° C. and part A was added and stirred uniformly. Next, no. No. 7 was added and stirred. Nos. 5 and 6 were added. 4 was added, and the mixture was stirred and mixed uniformly to adjust the pH to 9.0 to 9.5, thereby obtaining the target curling agent 1 solution.

(2 liquids)
Component Blending amount (% by weight)
----------------------------------
1 EDTA-2Na 0.10
2 Na bromate 4.00
3 Ammonium phosphate 0.50
4 Cationic NH (Nippon Seika) 2.00
5 Cetrinium chloride (30%) 1.00
6 Ores-50 0.20
7 Dimethicone copolyol 0.50
8 Sodium benzoate 0.15
9 Purified water Total amount of 100 -----------------------------------
(Preparation method)
No. 4-7 were heated to about 80 ° C. and dissolved (part A). In another container 9 (70%) and No. 9 1 and 8 were added and heated to about 80 ° C. to dissolve (Part B). In another container, no. No. 9 and No. 9 A few were added and heated to about 50 ° C. to dissolve (Part C). Add part B to part A and mix and stir uniformly to emulsify, then add part C when the temperature reaches 40 ° C., mix well, and adjust the pH to 6.5 to 6.8 at room temperature. Curl agent 2 liquid was obtained.

Example 30 Hair restorer The following formula was prepared. This hair restorer was able to prevent hair loss, dandruff and itching.

Component Blending amount (% by weight)
----------------------------------
Penetration enhancing composition of Example 1 2.00
Menthol 0.10
Pepper tincture 0.50
Assembly extract 2.00
Ethanol 30.00
Preservative Suitable amount Fragrance Suitable amount PPG-6 Decyltetradeces-30
Purified water Total amount of 100 ----------------------------------
(Production method)
Each component was stirred and mixed uniformly.

Example 31 A hair essence not washed off A hair essence having the following formulation was prepared. When this hair essence was applied to the hair, the hydrolyzed keratin penetrated into the hair, and the hair slipped, cohered, touched, moistened, and smooth on the hair surface.

Component Blending amount (% by weight)
--------------------------------
Penetration enhancing composition of Example 2 2.0
Hydrolyzed keratin aqueous solution (number average molecular weight 400, evaporation residue concentration 25%)
2.0
Cetrimonium chloride (25%) 0.6
Glycerin 5.0
Phenoxyethanol 0.2
Polyquaternium-6 0.8
Betaine 0.8
Ethanol 20.0
Purified water Total amount of 100 --------------------------------
(Preparation method)
Dissolve all ingredients uniformly.

Example 32 Non-washing hair treatment A non-washing hair treatment of the following formulation was prepared. When this hair treatment was applied to the hair, the hydrolyzed wheat protein penetrated into the hair, and the slipping, gathering, fingering, moist feeling, and smoothness of the hair surface were improved.

Component Blending amount (% by weight)
--------------------------------
Part A Penetration promoting composition of Example 3 2.0
Hydrolyzed wheat protein aqueous solution (number average molecular weight 700, evaporation residue concentration 20%)
2.0
Cetrimonium chloride (25%) 3.8
Caprylyl glucoside (50%) 0.8
Glycerin 4.0
Phenoxyethanol 0.2
Part B Ethanol 20.0
Part C Polyquaternium-6 0.6
Polyquaternium-7 0.4
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part C is heated to about 80 ° C. and dissolved. A part A is added to this, and it is made to melt | dissolve uniformly and it is made to cool to about 40 degreeC. Next, part B is added and mixed uniformly.

Example 33 Moist Charge Water A moist charge water having the following formulation was prepared. When this moist charge water was sprayed on the hair, the slip and unity improved, and a moist feeling could be imparted.

Component Blending amount (% by weight)
--------------------------------
Part A Penetration promoting composition of Example 4 5.0
Hydrolyzed keratin aqueous solution (number average molecular weight 400, evaporation residue concentration 25%)
1.0
Pentylene glycol 2.0
Phenoxyethanol 0.2
Stearyl trimonium chloride (64%) 4.6
Caprylyl glucoside (50%) 1.0
Dicocodimonium chloride (74%) 0.8
Lauramide DEA 1.0
PEG-60 hydrogenated castor oil 0.8
Part B Castor oil 0.2
Ethanol 20.0
Part C Polyquaternium-10 0.2
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part C is heated to about 80 ° C. and dissolved. A part A is added to this, and it is made to melt | dissolve uniformly and it is made to cool to about 40 degreeC. Next, part B is added and mixed uniformly.

Example 34 Acid hair dye (hair manicure)
An acid hair dye having the following formulation was prepared. This acidic hair dye was an acidic hair dye that has good dyeability when applied to the hair and can impart good feel such as flexibility and slipping to the hair.

Component Blending amount (% by weight)
--------------------------------
1 Penetration promoting composition of Example 1 2.00
2 N-methylpyrrolidone 15.00
3 Benzyl alcohol 8.00
4 Citric acid 1.00
5 Brown 201 0.13
6 Black 401 0.05
7 Purified water Total amount of 100 --------------------------------
(Preparation method)
Each component was mixed uniformly.

Example 35 Perm Agent A perm agent having the following formulation was prepared. This permanent agent was a permanent agent that gave hair a feeling of slipping and softness when applied to the hair.

(1 liquid)
Component Blending amount (% by weight)
--------------------------------
1 Penetration enhancing composition of Example 1 1.00
2 Polyquaternium-22 2.00
3 Hydrolyzed keratin aqueous solution (number average molecular weight 400, evaporation residue concentration 25%)
2.00
4 Monoethanolamine 1.00
5 Ammonia water (28%) 1.00
6 PEG-50 hydrogenated castor oil 0.20
7 Ammonium bicarbonate 2.00
8 Phosphoric acid 2Na 0.50
9 Ammonium thioglycolate aqueous solution (50%) 11.50
10 Cysteine 1.50
11 EDTA-4Na 0.15
12 Hydroxide Na 0.25
13 Polyquaternium-10 0.10
14 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. No. 14 in most of No. 14. 12 is dissolved, and then No. 12 is dissolved. No. 13 was added in small portions and dissolved. 9 to 11 were added and dissolved (part A). No. in a separate container. Take the rest of 14 7, 8 was added and heated and dissolved (part B). No. in a separate container. 1-6 was added, it heated at about 50 degreeC, and it was made to melt | dissolve (part C). Part B was added to part A and mixed uniformly, then part C was gradually added and mixed uniformly.

(2 liquids)
Component Blending amount (% by weight)
--------------------------------
1 Penetration enhancing composition of Example 1 0.50
2 Sodium benzoate 0.20
3 Edetic acid 2Na 0.10
4 Diammonium phosphate 0.10
5 Emmacol TS-703 (Sanei Chemical) 2.00
6 Stearyltrimonium chloride (50%) 2.00
7 Na bromate 10.00
8 Emmacol NZ (Sanei Chemical) 4.00
9 Ores-20 3.00
10 Purified water Total amount of 100 --------------------------------
(Preparation method)
No. Take most of 10 and heat to about 60 ° C. No. 1 to 3 were added and dissolved. 4 was added and dissolved. Then No. No. 5 and 6 were added, and the mixture was heated and dissolved. 7-9 was added and made uniform. The remaining No. 10 was added, mixed uniformly and cooled.

Example 36 Hair Essence A hair essence having the following formulation was prepared. This hair essence was excellent in penetrating active ingredients, had a refreshing feel, was not sticky, and was able to impart softness and slipperiness to the hair.

Component Blending amount (% by weight)
--------------------------------
Part A Penetration promoting composition of Example 1 2.00
Plandool-H (Nippon Seika) 0.50
Diethyl sebacate 0.50
Diisopropyl sebacate 0.50
Cetanol 1.00
Behentrimonium chloride (80%) 0.60
Distearyldimonium chloride (75%) 2.80
Tetraoleic acid Solves-60 1.00
PEG-40 hydrogenated castor oil 0.20
Part B Pantothenyl ethyl ether 2.00
Carbomer liquid (2%) 1.00
Xanthan gum solution (2%) 1.00
Citric acid appropriate amount Citric acid Na appropriate amount Methylparaben 0.10
Phenoxyethanol 0.10
Purified water Total amount to be 100 in total --------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was taken in another container and dissolved by heating to about 80 ° C. Part B was gradually added to part A and mixed uniformly.

Example 37 Hair Color Shampoo A hair color shampoo having the following formulation was prepared. This shampoo for hair color suppresses discoloration of the hair color, and provides a touch improvement such as glossiness and moisturization and a lasting effect.

Component Blending amount (% by weight)
--------------------------------
1 Poly (HEMA glucoside) (20%) (Nippon Seika) 4.00
2 Cocoyl Methyl Taurine Na (30%) 15.00
3 Olefin (C14-16) sulfonic acid Na (36%) 13.00
4 Sodium cocoamphoacetate (30%) 8.00
5 PPG-12-PEG-50 Lanolin 2.50
6 Cocoyl glutamic acid (30%) 7.00
7 Polyquaternium-10 1.00
8 Lauramidopropylhydroxysultain / water 4.00
9 PEG-20 hydrogenated castor oil 2.00
10 Sunflower Ceramide (LABORATORIES
SEROBIOLOGIQUES) 0.50
11 Proticute U Alpha (Ichimaru Falcos) 0.50
12 Etidronic acid 0.20
13 PG 0.20
14 Penetration enhancing composition of Example 1 0.05
15 Methylparaben 0.20
16 Phenoxyethanol 0.20
17 Purified water Total amount of 100 ---------------------------------
(Preparation method)
No. No. 17 After adding 7 and stirring, warm to about 80 ° C. to dissolve (A). In another container 13 is weighed and 14, no. No. 15 was added and blended. 6 is added and heated to about 80 ° C. to dissolve (B). B is added to A. 2-No. Add 5 in order and stir uniformly (C). In another container 1, no. 8-No. 10 is weighed and dissolved at about 80 ° C. (D). While heating to about 80 ° C., D was added to C, and the mixture was stirred and dissolved uniformly. 11, no. 12, no. After adding 16 and stirring well, it is cooled to room temperature and adjusted to pH 5.5 to 6.0.

  According to the present invention, it is possible to obtain a penetration enhancer that has an excellent penetration promoting effect on the hair of an active ingredient and also has water solubility, and by blending this into a hair cosmetic, the penetration penetration of the active ingredient is promoted. , Can enhance the effect. Furthermore, a hair cosmetic with enhanced effects of active ingredients can be obtained.

Claims (4)

A hair cosmetic containing the following components (A) and (B).
(A) Protein peptides and derivatives thereof, amino acids and salts and derivatives thereof, water-soluble active ingredients selected from pantothenic acid, pantothenyl ethyl ether, and panthenol (B) Cyclohexanedicarboxylic acid and chemical formula 2 Diester with polyoxyethylene monoalkyl ether
R2- (OCH2CH2) n-OH
(Wherein R2 is a linear, branched or cyclic hydrocarbon group having 1 to 12 carbon atoms, and n represents an integer of 2 to 11) (A) is keratin-degrading peptide, hydrolyzed keratin, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptide, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl The hair cosmetic according to claim 1, wherein the hair cosmetic is selected from hydrolyzed silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, and casein degrading peptide. The hair cosmetic composition according to any one of claims. 1 to 2 R2 polyoxyethylene monoalkyl ether is a methyl group or an ethyl group shown in Chemical formula 2. Polyoxyethylenated monoalkyl ether represented by 2, diethylene glycol monoethyl ether, hair cosmetic according to any one of claims 1-2 it is one or two elements selected from triethylene glycol monoethyl ether.