JP2019189556A - Phosphatidylinositol-containing complex - Google Patents

Abstract

To provide compositions capable of easily emulsifying or solubilizing phosphatidylinositol in water without using a synthetic surfactant, the composition exerting an excellent physiological activity.SOLUTION: A complex obtained by removing from a solution in which component (A) of a phospholipid composition consisting of component phosphatidylinositol and lecithin, and component (B) of sterols are uniformly dissolved in an organic solvent the organic solvent and by simultaneously precipitating the components (A) and (B) is used, the content of the component (A) being 60 to 99%, and the content of the component (B) being 1 to 40%.SELECTED DRAWING: None

Description

  The present invention is obtained by removing an organic solvent from a solution in which a phospholipid composition comprising phosphatidylinositol and lecithin and a sterol are uniformly dissolved in the organic solvent, and simultaneously depositing the phospholipid composition and the sterol. Phosphatidylinositol-containing complex.

  Lecithin is a general term for glycerophospholipids obtained from animals or plants, and is widely used as a natural emulsifier in foods, cosmetics, pharmaceuticals and the like. The components of lecithin are classified according to the structure of the polar group bonded to the phosphate group, such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidic acid (PA), etc. Is known to be a major component. In recent years, studies have been conducted focusing on each of these functions and effects, and it is known that PI is deeply related to the information transmission function inside and outside the cell, and the blood triglyceride concentration by PI intake Physiological effects such as reduction and increase in HDL cholesterol have been reported. As cosmetic applications, physiological effects such as increasing hyaluronic acid in the skin (Patent Document 1) and enhancing Nrf2 activity (Patent Document 2) have been reported. When PI is used as an active ingredient for various purposes, it is important to obtain a composition containing PI at a high concentration. As a method for this, lecithin has long been separated by solvent fractionation (for example, Patent Document 3) or column purification. However, there are problems in manufacturing complexity and cost. On the other hand, recently, a method for efficiently producing PI using phospholipase B that specifically acts on phospholipids other than PI (Patent Documents 4 and 5) has been developed, and a composition containing PI at a high concentration has been industrially developed. Therefore, it is possible to obtain a new application of PI. However, PI is inferior to other phospholipids in emulsifying power, and it is very difficult to uniformly disperse PI alone in water. As a method for solving such a problem, for example, a method using a polyoxyethylene surfactant or the like (Patent Document 6) is known. There was concern, and a method without using a synthetic surfactant was desired.

  In Patent Document 7, as a method of dispersing lecithin having poor hydration properties in water, the organic solvent is removed from a solution in which lecithin and sterol are uniformly dissolved in the organic solvent, and lecithin and sterol are precipitated simultaneously. The resulting lecithin-sterol complex is disclosed. In Patent Document 8, the organic solvent is removed from a solution in which the poorly water-soluble physiologically active substance and the phospholipid are uniformly dissolved in the organic solvent, and the poorly water-soluble physiologically active substance and the phospholipid are simultaneously added. A poorly water-soluble physiologically active substance-phospholipid complex obtained by precipitation is disclosed, and by using the complex, a poorly water-soluble physiologically active substance can be easily emulsified or solubilized. It is described that the dispersion stability is also good. However, a complex in which a phospholipid composition composed of phosphatidylinositol and lecithin and a sterol are blended at a specific ratio has not been known.

International Publication No. 2009/110205 JP 2011-168541 A JP 60-246305 A International Publication No. 2007/010892 JP2015-27260A JP2012-77000 JP-A-4-149194 JP 2007-197328 A

  As a result of various studies on phosphatidylinositol, which has not been widely used for cosmetics, the present inventors have various physiological activities including actions that have not been known so far. I found it very useful. On the other hand, it has been found that blending into cosmetics is very difficult due to its low dispersibility in water. Accordingly, an object of the present invention is to provide a composition capable of easily emulsifying or solubilizing phosphatidylinositol in water without using a synthetic surfactant, and the composition has excellent physiological activity. It is also one of the problems of the present invention to exert the action.

As a result of intensive studies to solve the above problems, the present inventors have removed the organic solvent from a solution in which the following components (A) and (B) are uniformly dissolved in the organic solvent, and the components (A ) A composite obtained by simultaneously depositing (B), wherein the content of component (A) is 60 to 99%, and the content of component (B) is 1 to 40%. By using it, it discovered that the said subject was solved and completed this invention.
(A) Phospholipid composition comprising the following components (A1) and (A2) (A1) Phosphatidylinositol (A2) Lecithin (B) Sterols

  By using the complex of the present invention, phosphatidylinositol can be easily emulsified or solubilized in water. Moreover, the emulsified or solubilized composition obtained has a transparent appearance and its dispersion stability is good. In addition, the complex of the present invention exhibits the excellent physiological activity of phosphatidylinositol such as hyaluronic acid production promoting action, intracellular active oxygen scavenging action, whitening action, collagen production promoting action, etc. The use as a complex is more effective than the use of phosphatidylinositol alone.

  The composite as used in the present invention refers to a composite that exhibits one physicochemical property as a composite while a mixture of a plurality of substances maintains individual chemical properties. For example, the behavior with respect to temperature changes due to the composite, and the solubility and dispersibility in a solvent change.

  The complex of the present invention removes the organic solvent from the solution in which the phospholipid composition comprising phosphatidylinositol and lecithin and the sterols are uniformly dissolved in the organic solvent, and precipitates the phospholipid composition and the sterols simultaneously. Is obtained.

  The method for producing the composite of the present invention is as follows. First, a phospholipid composition comprising phosphatidylinositol and lecithin and sterols are uniformly dissolved or dispersed in an organic solvent. At this time, it can be performed efficiently by using means such as heating and stirring. Next, the organic solvent is removed from the organic solvent solution to precipitate the phospholipid composition and sterols simultaneously. As this method, for example, the organic solvent solution is heated or / and the organic solvent is distilled off under reduced pressure, the organic solvent solution is spray-dried, or the organic solvent is instantly frozen with liquid nitrogen or the like. Thereafter, a method of freeze-drying and the like can be mentioned. Although the target complex can be obtained in a semi-solid, solid, or powder state by such a method, it is preferably obtained in a powder form from the viewpoint of the swelling speed when dispersed in water. From this, it is preferable to use spray drying and freeze drying as the production method. Further, as the spray drying, the organic solvent solution is supplied to the tubular heater at a constant rate, and the organic solvent is heated in the heater. It is most preferable to use a device that instantaneously evaporates the organic solvent (instantaneous vacuum dryer) by evaporating the mixture into a mixture of substantially solids and vapor of the organic solvent, and introducing the mixture into the vacuum chamber at high speed. preferable. Details of this apparatus are described in Patent Document 7.

  The organic solvent used in the production of the composite of the present invention is not particularly limited as long as it can uniformly dissolve or disperse all components to be complexed. For example, hydrocarbons such as pentane, hexane, heptane, and cyclohexane Halogenated hydrocarbons such as methylene chloride and chloroform; aromatic hydrocarbons such as benzene and toluene; lower alcohols such as methanol, ethanol, isopropanol and t-butyl alcohol; esters such as methyl acetate and ethyl acetate; Can be mentioned. These organic solvents may be used alone or in combination of two or more. Of these, hydrocarbons such as pentane, hexane, heptane, and cyclohexane, and lower alcohols such as methanol, ethanol, isopropanol, and t-butyl alcohol are preferable from the viewpoints of solubility and safety.

  The amount of the organic solvent used in the production of the complex of the present invention is not particularly limited as long as all components to be complexed are uniformly dissolved or dispersed, but depending on the solubility of the component to be complexed The amount used can be changed as appropriate. In general, it is preferable to use 1 to 100 times by weight, preferably 3 to 50 times by weight, based on all components to be combined.

  The component (A1) phosphatidylinositol (hereinafter also referred to as PI) used in the present invention is one of phospholipids present in plants such as soybean, rapeseed, sunflower, corn, and palm in nature. Included in lecithin extracted from A composition containing PI at a high concentration can be obtained from such lecithin by solvent fractionation, column purification, or fractionation by a method using an enzyme described later. In the present invention, such a high concentration can be obtained. A PI-containing composition can be used as component (A1). As a high concentration PI-containing composition, a PI content of 40% by weight or more, preferably 50% by weight or more may be used. As a method for producing a high-concentration PI-containing composition, phospholipase B that specifically acts on phospholipids other than PI is used in addition to solvent fractionation and column purification that have been known for a long time, and PI such as PC, PE, PA, etc. Methods have been developed in which the remaining PI is selectively hydrolyzed after the other phospholipids are selectively hydrolyzed (Patent Documents 4 and 5). For this reason, it is possible to obtain a high-concentration PI-containing composition industrially and inexpensively, and Soy Brain PI50 (manufactured by Unitech Foods) is sold as a commercial product. In this invention, such a commercial item can be used preferably.

  As the component (A2) lecithin used in the present invention, natural lecithin obtained from plants such as soybean, rapeseed, sunflower, safflower, peanut, cottonseed, corn, rice, barley, and egg yolk, and hydrogenated products thereof. Can be illustrated. Furthermore, these may be derivatives modified with a polyoxyalkylene group such as polyethylene glycol. These may be used singly or in combination of two or more. Generally, natural plant-derived lecithin contains about 30% by weight of phosphatidylcholine (hereinafter also referred to as “PC”), but commercially available products with increased PC content by solvent fractionation are commercially available. In the present invention, it is preferable to use one having an increased PC content from the viewpoint of improving emulsification or solubilization ability, and the PC content in the component (A2) is 50 to 99% by weight, more preferably 70 to 99. It is good to be weight%. As mentioned above, the plant-derived lecithin contains about 10 to 20% of PI, but lecithin whose PC content has been increased by solvent fractionation is almost free of PI because it is removed in the fractionation process. Therefore, in order to obtain a phospholipid composition having a high PC content and containing PI, it is necessary to mix a high concentration PI-containing composition with lecithin with an increased PC content. Since lecithin obtained from egg yolk naturally contains about 70% by weight of PC (not including PI), it can be preferably used as component (A2), but in view of consumers' natural orientation, plant-derived lecithin may be used. preferable. From the viewpoint of improving the feeling of use when the complex of the present invention is dispersed in water, it is preferable to use a mixture of hydrogenated lecithin and non-hydrogenated lecithin as the component (A2). The mixing ratio of hydrogenated lecithin and non-hydrogenated lecithin may be 99: 1 to 70:30, more preferably 97: 3 to 80:20 by weight.

  The blending ratio of the components (A1) and (A2) used in the present invention is not particularly limited, but is 5 by weight from the viewpoint of sufficiently exerting the emulsification or solubilizing ability and the physiological activity of the present invention. : 95-50: 50, preferably 10: 90-30: 70.

  Specific examples of the sterols of component (B) used in the present invention include sterols derived from animals such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, desmosterol; stigmasterol, sitosterol, campesterol, brassica Examples include sterols and sterols derived from plants such as phytosterol which are mixtures thereof; sterols derived from microorganisms such as ergosterol; γ-oryzanol; ursolic acid; glycyrrhetinic acid; and esterified products thereof. These sterols may be used alone or in combination of two or more. Among these sterols, cholesterol, phytosterol, and γ-oryzanol are preferable from the viewpoint of sufficiently exerting the effects of the present invention.

  The composite of the present invention may further contain an antioxidant as component (C) for the purpose of improving the storage stability of the composite or the emulsified or solubilized composition prepared using the composite. Good. Specific examples of antioxidants include tocopherol and its derivatives, tocotrienol and its derivatives, gallic acid and its derivatives, ascorbic acid and its derivatives, vitamin A, carotenoids, lipoic acid, coenzyme Q10, ubiquinol, butylhydroxy Examples include toluene and butylhydroxyanisole. Of these, tocopherol and its derivatives, carotenoids, lipoic acid, and coenzyme Q10 are preferable.

  As the composition of the composite of the present invention, when the composite is composed of the components (A) and (B), the content of the component (A) in the composite is 60 to 99% by weight, and the component (B) The content may be 1 to 40% by weight, more preferably the content of component (A) is 70 to 98% by weight, and the content of component (B) is 2 to 30% by weight. When the component (C) is further contained as a composite, the content of the component (A) in the composite is 40 to 99.99% by weight, and the content of the component (B) is 1 to 40% by weight. The component (C) content may be 0.01 to 20% by weight, more preferably the component (A) content is 70 to 97% by weight, and the component (B) content is 2 to 20%. The content of weight and component (C) is 1 to 10%.

  By using the complex of the present invention thus obtained, phosphatidylinositol which is difficult to emulsify or solubilize by itself can be easily emulsified or solubilized. Moreover, phosphatidylinositol which is the component (A1) of the present invention has excellent physiological activities such as hyaluronic acid production promoting action, intracellular active oxygen scavenging action, whitening action, collagen production promoting action, etc. The composite of the present invention to be contained naturally has an excellent physiological activity, but surprisingly, the effect is better when used as a composite than when PI is used alone.

  When the complex of the present invention is emulsified or solubilized in water, it can be prepared by adding the complex as it is to water and stirring and mixing, but the complex is once dispersed in a polyhydric alcohol. Preferably, water is added to the polyhydric alcohol dispersion while stirring, or the polyhydric alcohol dispersion is added to the water while stirring. The emulsified or solubilized composition prepared by such a method has a transparent feeling due to its appearance, and its dispersion stability becomes better. In the present invention, “transparency” means that the appearance of the liquid is transparent when the sample is placed in a glass bottle having a diameter of 3.5 cm and observed from the side. Therefore, if such a polyhydric alcohol dispersion (premix composition) is prepared in advance, the preparation of the emulsified or solubilized composition becomes easier. Specific examples of the polyhydric alcohol in which the complex of the present invention is dispersed include ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3- Butylene glycol, 2-methyl-1,3-propanediol, 3-methyl-1,3-butanediol (isopentyldiol), tetramethylene glycol, hexylene glycol, caprylyl glycol, 1,2-pentanediol, 1 , 2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol and other dihydric alcohols; glycerin, trimethylolpropane, 1,2,6-hexanetriol, etc. Trivalent alcohol; sorbitol, xylitol, erythritol, mal Sugar alcohols such as Toll, Mannitol, Pentaerythritol; Glyceryl ethers such as ethyl glycerin, butyl glycerin, hexyl glycerin, ethyl hexyl glycerin; diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol And polyhydric alcohol polymers such as diglycerin, triglycerin, tetraglycerin and polyglycerin. These may be used singly or in combination of two or more. Among these, from the viewpoint of transparency and dispersion stability of the obtained emulsified or solubilized composition, glycerin, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, Xylene glycol, 1,2-pentanediol, and 1,2-hexanediol are preferred, and in particular, one or more selected from hexylene glycol, 1,2-pentanediol, and 1,2-hexanediol. Is essential.

  Cosmetics containing the composite of the present invention include water and additives added to normal cosmetics as necessary, such as oil bases, surfactants, alcohols, humectants, polymers, thickeners, Gelling agent, antioxidant, antiseptic, bactericidal agent, chelating agent, pH adjuster / acid / alkali, UV absorber, whitening agent, solvent, exfoliating / dissolving agent, antipruritic agent, anti-inflammatory agent, antiperspirant, Refreshing agents, antihistamines, astringents, stimulants, hair growth agents / blood circulation promoters, reducing agents / oxidants, polymer powders, hydroxy acids, vitamins and derivatives thereof, saccharides and derivatives thereof, organic acids, enzymes , Nucleic acids, hormones, inorganic powders, fragrances, pigments and the like may be contained to the extent that the effects of the present invention are not impaired.

  Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as cannic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Hydrocarbons such as paraffin; candelilla wax, carnauba wax, rice wax, wax wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Tropsch wax, polyethylene wax, waxes such as ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cacao butter, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Fats and oils; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof, phospholipids such as lysolecithin; Phospholipid derivatives such as lipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; sapogenins; saponins; cholesteryl acetate, nonanoic acid Lesteryl, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamate di (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl- Acyl sarcosine alkyl esters such as L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N-lauroylsarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid Cholesteryl, macadamia nut oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, isostearic acid phytosteryl, soft lano Sterol esters such as phosphofatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid / cholesterol complex, phospholipid / phytosterol complex; octyl myristate Dodecyl, hexyldecyl myristate, octyldodecyl isostearate, cetyl parimitate, octyldodecyl palmitate, cetyl octoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isopentyl neopentanoate, Isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyl oleate Dodecyl, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, ethyl avocado oil, isopropyl myristate, isopropyl palmitate, palmitic Octyl acid, isopropyl isostearate, lanolin fatty acid isopropyl, methyl heptyl laurate, methyl heptyl myristate, methyl heptyl palmitate, methyl heptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyl sebacate Octyl, diisobutyl adipate, dioctyl adipate, dioctyl succinate, citric acid Monoalcohol carboxylates such as triethyl; oxyacid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, γ-ercalactone; glyceryl trioctanoate, glyceryl trioleate, triisostearic acid Glyceryl, glyceryl diisostearate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), Glyceryl behenate, glyceryl trioctanoate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol octanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, (isostearic acid / sebacic acid) Ditrimethylolpropane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / rosin acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid / ricinolein) Acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethyl distearate) Lenglycol), polymethyl alcohol fatty acid esters such as 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate; alkyl ethers such as dicaprylyl ether; Diisopropyl merlinoleate, diisostearyl dimerlinoleate, dimerisolinoleate di (isostearyl / phytosteryl), dimerlinoleic acid (phytosteryl / behenyl), dimerlinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) ), Dimer dilinoleic acid dimer dilinoleyl, diisostearic acid dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl dimer dilinole Dimer acid or dimer diol derivative such as ruether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA) , Fatty acid alkanolamides such as lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); Polysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclope) Tasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, aminopropyldimethicone and aminomodified silicone such as amodimethicone, cation Polyether modified silicone such as modified silicone and dimethicone copolyol, polyglycerin modified silicone, sugar modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid Modified silicone, peptide modified silicone, fluorine modified silicone, cation modified and polyether modified silicone Silicones such as corn, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, polysiloxane-oxyalkylene copolymers; Fluorine-based oils such as perfluorooctane and perfluoropolyether are preferred.

  As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosane diacid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan Sulfuric acid; white jellyfish extract; white jellyfish polysaccharide; fructans such as inulin and levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; organic acids such as citric acid, tartaric acid and lactic acid and salts thereof; urea; 2-pyrrolidone-5 -Carboxylic acid and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine Amino acids and salts thereof such as glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagenolytic peptide, Hydrolyzed collagen, Hydroxypropylammonium chloride hydrolyzed collagen, Elastin degrading peptide, Keratin degrading peptide, Hydrolyzed keratin, Conchiolin degrading peptide, Hydrolyzed conchiolin, Silk proteolytic peptide, Hydrolyzed silk, Lauroyl hydrolyzed silk sodium, Soy protein Peptides, wheat proteolytic peptides, hydrolyzed wheat proteins, casein degrading peptides, acylated peptides and other protein peptides and their Derivatives; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, Glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract Animal / plant extract components such as eucalyptus extract and merirot extract, natural ceramide (type 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide and sugar ceramide-containing extract Ceramides can be mentioned as preferred.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium phosphate, cocoyl glutamate triethanolamine, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine, lysine Na dilauroyl glutamate; sodium laureth acetate, etc. Polyoxyethylene alkyl ether acetates; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; Fatty acid glyceride sulfate such as coconut oil fatty acid sodium glycerin sulfate; Oxyethylene sulfate; Olefin sulfonate such as sodium α-olefin sulfonate; Alkyl sulfosuccinate such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; Disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate Alkyl ether sulfosuccinates such as sodium acid, sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonate; alkanesulfonate; α-sulfo fatty acid methyl ester salt; acyl isethionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetates; alkyl ether phosphates such as sodium laureth phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate esters such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphorus Acid salts; Fatty acid amide ether phosphates; Phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof; Silicone shades such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone Nonionic surfactants such as ionic surfactants, laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steale Various polyoxyethylene addition numbers such as bis (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether), octyldecesses (polyoxyethylene octyldodecyl ether) Polyoxyethylene alkyl ethers; polyoxyethylene alkyl phenyl ethers; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, Castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid; poly Polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether; Polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol ; (Poly) glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; Glyceryl isostearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl palm oil fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-pyroglutamate oleate, monostearate Glycerin fatty acid partial esters such as glyceryl malic acid; polyglyceryl stearate-2, 3, 4, 5, 6, 8, 8, disglyceryl-6, 10, polyglyceryl tristearate 2, polyglyceryl-10 decastearate, polyglyceryl-2 isostearate, 3, 4, 5, 6, 6, 8, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 1 Polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, dioleate polyglyceryl- 6, polyglyceryl fatty acid ester such as polyglyceryl-2 trioleate, polyglyceryl-10 dekaoleate; ethylene glycol mono fatty acid ester such as ethylene glycol monostearate; propylene glycol mono fatty acid ester such as propylene glycol monostearate; pentaerythritol moiety Fatty acid ester; sorbitol partial fatty acid ester; maltitol partial fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate Sorbitan fatty acid esters such as sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; Sugar derivative partial esters such as sucrose fatty acid ester, methyl glucoside fatty acid ester and undecylenic acid trehalose; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; glycolipid such as mannosyl erythritol lipid; lanolin alcohol; reduced lanolin; Stearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate, etc. Polyoxyethylene fatty acid mono- and diesters; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene sorbitan monooleate; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate, and other polyoxyethylene sorbitan fatty acid esters; poly Oxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene Polyoxyethylene sorbitol fatty acid esters such as bitol pentaoleate and polyoxyethylene sorbitol monostearate; Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax Alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; Natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil fatty acid monoethano Luamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide Fatty acid alkanolamides such as (partamide MEA), palmitic acid diethanolamide (partamide DEA), and palm oil fatty acid methylethanolamide (cocamidomethyl MEA); alkyl such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide Polydimethyl ether oxide; alkyl ethoxy dimethyl amine oxide; polyoxyethylene alkyl mercaptan; polyether such as dimethicone copolyol Silicone-based nonionic surfactants such as silicone-modified silicones, polysiloxane / oxyalkylene copolymers, polyglycerin-modified silicones, sugar-modified silicones, etc .; for cationic surfactants, behentrimonium chloride, steartrimonium chloride Alkyltrimethylammonium chloride such as cetrimonium chloride and lauryltrimonium chloride; alkyltrimethylammonium bromide such as stearyltrimonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; stearamidepropyldimethylamine; Fatty acid amidoamines such as stearamide ethyl diethylamine and salts thereof; alkyl ether amines such as stearoxypropyldimethylamine; and Salt or quaternary salt of fatty acid amide type quaternary ammonium salt such as ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamine and its Alkylamine salt; fatty acid amidoguanidinium salt; alkyl etheraminemonium salt; alkyltrialkylene glycol ammonium salt; benzalkonium salt; benzethonium salt; pyridinium salt such as cetylpyridinium chloride; imidazolinium salt Alkyl isoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyl dimethicone and amodimethicone; cation-modified silicones; And silicone-based cationic surfactants such as polyether-modified silicone, amino-modified and polyether-modified silicone; amphoteric surfactants such as N-alkyl-N, N- Dimethylamino acid betaine; fatty acid amide alkyl-N, N-dimethylamino acid betaine such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline type betaine such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaine such as alkyldimethyltaurine; alkyl Sulfate-type betaines such as dimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; phosphatidylcholine, phosphatidylethanolamine , Sphingophospholipids such as phosphatidylserine and sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, hydroxylated lecithin, etc .; silicone Preferred examples of the polymeric surfactant include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymer; and various silicone surfactants.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationic cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazoline derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzoyl chloride Luconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol , Photosensitizers, antibacterial zeolite, and silver ion are preferable, but when used as an antibacterial agent or antiseptic agent for antiseptic purposes, phenoxyethanol; 1 from the viewpoint of safety of cosmetics or skin external preparations; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.

  Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

  Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid-based UV absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone purple 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphsulfone Preference is given to acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

  Vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol / acetic acid tocopherol, derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and derivatives thereof; , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

  Plant / animal / microbe extracts include iris extract, ashitaba extract, asunaro extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menton, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.

  As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 3, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1, red 105-1, red 106, red 2, red 3, red 201, red 202, red 203, red 204, red 205, red 206, red 207 , Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 28, red 230-1, red 230-2, red 231, red 232, red 3, red 401, red 404, red 405, red 501, red 502, red 503 Red 504, red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202-1, yellow 202-2, yellow 203, yellow 204, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, Yellow 406, Yellow 407, Yellow 5 and other legal dyes; Acid Red 14 and other acidic dyes; Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow and other basic dyes; HC Yellow 2 Nitro dyes such as HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26, etc. Dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (Bengara) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and loess Pigments; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; ultramarine and bitumen Inorganic blue pigments: Titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, pearl pigments; aluminum powder, Metal powder pigments such as perpowder and gold; anthraquinones such as astaxanthin and alizarin; anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, naphthoquinones such as cochineal, shikonin, bixin, Natural pigments and dyes such as flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylene Oxidative dye intermediates and couplers such as diamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; auto-oxidizing dyes such as indoline; dihydroxyacetone is preferred And the like as correct ones.

  Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  Examples of the cosmetics of the present invention include hair cosmetics, skin cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and skin external preparations such as ointments. The cosmetic of the present invention can be produced according to a usual method.

  The cosmetic or skin external preparation of the present invention will be described in further detail. Examples of hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, and rinse-integrated shampoos. Rinsing, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow, split hair coat , Hair oil, permanent wave agent, straight permanent agent, oxidative hair dye, hair bleach, hair color pretreatment, hair color after treatment, permanent pretreatment, permare Terpolymers treatments, hair manicure, and as hair growth agents are preferred.

  Skin cosmetics include lotions such as soft lotion, astringent lotion, cleansing lotion, multi-layer lotion; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, Nourishing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; Liposome cosmetics such as liposomal serum and liposome lotion; packs and masks such as peel-off pack, powder pack, washing pack, oil pack, cleansing mask; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing gel Facial cleansers such as oils, cleansing masks, powders and facial cleansers; cosmetic soaps, transparent soaps, medicated soaps, liquid soaps, shaving soaps, synthetic cosmetic soaps Soap can be mentioned as preferred.

  As makeup cosmetics, white powder, dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment are preferable. .

  Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.

  Body cosmetics include body shampoos and other body cleansers, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics, depigmenting agents, depilation / hair removal agents, bathing agents, insect repellents, etc. A repeller is preferred.

  Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

  As the dosage form of the cosmetic or external preparation for skin of the present invention, emulsification such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type, etc. Type cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, pastes Preferred examples include cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

  The following examples further illustrate the present invention in detail but are not to be construed to limit the scope thereof.

<Manufacture of composite>
Each component (total 10 g) of the complex of the present invention having the composition shown in Table 1 was dissolved in 80 g of t-butyl alcohol, and then instantly frozen with liquid nitrogen, and freeze-dried (Tokyo Rika Kikai Co., Ltd., FDU-2200). The mold was freeze-dried. The pressure was 10 Pa or less and the trap temperature was −80 ° C. All the composites thus obtained were homogeneous light yellow powders. For comparison, composites having the compositions shown in Table 2 were similarly prepared.

<Preparation and evaluation of aqueous dispersion>
An aqueous dispersion having the composition shown in Table 3 was prepared using the composite obtained above. The obtained aqueous dispersion was evaluated for initial dispersibility, transparency and dispersion stability by the following methods, and the results are shown in the lower columns of Tables 1 and 2.

<Initial dispersibility>
About the obtained aqueous dispersion, the dispersion state immediately after preparation was observed visually, and initial dispersibility was evaluated according to the following evaluation criteria.

○ ・ ・ ・ Uniformly dispersed × ・ ・ ・ Not uniformly dispersed

<Transparency>
The obtained aqueous dispersion was put into a glass bottle having a diameter of 3.5 cm, the appearance was visually observed from the side, and the transparency was evaluated according to the following evaluation criteria.

○… The back of the liquid can be seen through △ ・ ・ ・ The back of the liquid can be seen through a little ×× The back of the liquid can be seen through

<Dispersion stability>
The obtained aqueous dispersion was subjected to a storage stability test at 50 ° C./month, and the dispersion stability was evaluated according to the following evaluation criteria.

○ ・ ・ ・ Uniformly dispersed after storage △ ・ ・ ・ Almost uniformly dispersed after storage × ・ ・ ・ Not uniformly dispersed after storage or precipitation occurs

  From the results shown in Table 1, the aqueous dispersion prepared using the composite of the present invention was excellent in initial dispersibility, transparency and dispersion stability. Moreover, when the usability was compared for the aqueous dispersions prepared with the composites of Example 1 and Example 2, the composite of Example 2 blended with unhydrogenated lecithin was more familiar to the skin, penetrating, etc. The feeling of use was excellent. In addition, as a result of comparing the appearances of the composites of Example 2 and Example 3 when stored at 50 ° C. for 2 weeks, the composite of Example 3 containing an antioxidant has a change in hue and odor. It turns out that there are few. On the other hand, from the results in Table 2, the composite of Comparative Example 1 having a high component (A1) ratio in the component (A) and the composite of Comparative Example 2 having a large amount of component (B) have satisfactory water dispersion. In the composite of Comparative Example 3 in which the liquid could not be prepared and the component (B) was not included in the composite, although the initial dispersibility and transparency were good, the dispersion stability was insufficient. Moreover, in the composite of Comparative Example 4 having a low PC content in the component (A2), although initial dispersion is possible, the transparency and dispersion stability are poor, and the PC content in the component (A2) is the water dispersion of the composite. It was thought to greatly affect the sex.

<Preparation and evaluation of aqueous dispersion 2>
An aqueous dispersion using the composite of the present invention having the composition shown in Table 4 was prepared. The obtained aqueous dispersion was measured for transmittance (cell thickness 1 cm, wavelength 600 nm) as an index of transparency, and the results are also shown in Table 4.

  From the results shown in Table 4, when the complex of the present invention is dispersed in water, 1,2-pentanediol, 1,2-hexanediol, and hexylene glycol are used as the polyhydric alcohol, whereby the dispersion can be transparent. It turns out that the nature becomes high. Moreover, it turned out that a highly transparent aqueous dispersion can be obtained even if other polyhydric alcohol is used by using these together.

<Evaluation of hyaluronic acid production promotion>
After normal human epidermal cells were cultured for 72 hours in the medium to which each test sample was added at the concentrations shown in Table 5, the amount of hyaluronic acid in the medium supernatant was quantified by ELISA. As a control, the amount of hyaluronic acid in a medium to which no test sample was added was quantified in the same manner. The results are shown in Table 5 as relative values with the amount of control hyaluronic acid as 100%.

  From the results in Table 5, it was found that the complex of the present invention had a significant increase in the amount of hyaluronic acid not only with no addition but also with phosphatidylinositol alone, and had an excellent hyaluronic acid production promoting effect.

<Intracellular reactive oxygen scavenging evaluation>
Normal human epidermal cells were cultured for 24 hours in a medium supplemented with each test sample at the concentrations shown in Table 6, and then washed with Hank's balanced salt solution (-) (HBSS (-)) to detect active oxygen. The fluorescent probe was exposed to HBSS (−) containing 2′-7′-Dichlorofluorescin (SIGMA) at a concentration of 20 μM for 45 minutes to allow the fluorescent probe to be incorporated into the cells. Then, the amount of intracellular active oxygen after 1 hour exposure to HBSS (-) containing 500 μM hydrogen peroxide as active oxygen was quantified with a fluorescent plate reader (EX / EM485 / 535 nm). As a control, the amount of intracellular active oxygen in a medium to which no test sample was added was quantified in the same manner. The results are shown in Table 6 as relative values with the amount of active oxygen in the control as 100%.

  From the results shown in Table 6, it can be seen that the complex of the present invention has a significant decrease in the amount of intracellular active oxygen not only with no addition but also with phosphatidylinositol alone, and has an excellent intracellular reactive oxygen scavenging action. I understood.

<Suppression evaluation of SLS-induced intracellular active oxygen>
Sodium lauryl sulfate (SLS) increases intracellular active oxygen. Normal human epidermal cells were cultured for 24 hours in a medium containing SLS 10 μg / mL and each test sample at a concentration shown in Table 7, and then washed with Hank's balanced salt solution (−) (HBSS (−)). Then, exposure to HBSS (−) containing 2′-7′-Dichlorofluorescin (SIGMA), which is a fluorescent probe for detecting active oxygen, at a concentration of 20 μM for 45 minutes, causes the fluorescent probe to be taken into cells, and intracellular reactive oxygen The amount was quantified with a fluorescence plate reader (EX / EM485 / 535 nm). As a control, the amount of intracellular active oxygen in a medium to which no test sample was added was quantified in the same manner. The results are shown in Table 7 as relative values with the amount of active oxygen in the control as 100%.

  From the results shown in Table 7, the complex of the present invention has a significantly reduced amount of SLS-induced intracellular active oxygen, not only with no addition but also with phosphatidylinositol alone, and has an excellent inhibitory effect on intracellular active oxygen. I found out that

<Inhibition of melanin production>
B16F10 mouse melanoma cells were cultured for 72 hours in a medium in which each test sample was added at the concentrations shown in Table 8. After completion of the addition culture, a 2N aqueous sodium hydroxide solution containing 10% dimethyl sulfoxide was added to the collected cells, and the mixture was heated to 60 ° C. to obtain a cell lysate. The amount of melanin in the pigment cells was quantified by measuring the absorbance of the obtained cell lysate at 450 nm. The protein concentration of the cell lysate was quantified using Protein Assay Day Reagent Concentrate (BIO-RAD) with bovine serum-derived albumin (Thermo Scientific) as a standard, and the amount of melanin per unit protein amount was calculated. As a control, the amount of melanin in a medium to which no test sample was added was similarly quantified. The results are shown in Table 8 as relative values with the amount of control melanin as 100%.

  From the results shown in Table 8, it can be seen that the composite of the present invention has an excellent melanin production inhibitory effect (whitening effect), not only with no addition but also with a significant decrease in the amount of melanin compared to phosphatidylinositol alone. It was.

<Collagen production promotion evaluation>
After normal human dermal fibroblasts were cultured for 72 hours in a medium to which each test sample was added at the concentrations shown in Table 9, the amount of type I collagen in the medium supernatant was quantified by ELISA. As a control, the amount of type I collagen in a medium to which no test sample was added was quantified in the same manner. The results are shown in Table 9 as relative values with the amount of control type I collagen as 100%.

  From the results in Table 9, it was found that the amount of type I collagen was significantly increased in the complex of the present invention as compared to the case where no addition was made, and there was an excellent type I collagen production promoting effect.

  The following cosmetics were produced using the composite of the present invention. The obtained cosmetic was excellent in moisture retention and penetration, prevented fine lines and rough skin, and the skin looked bright and bright.

Example 17 Moisturizing lotion

Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.25
BG 5.0
Glycerin 10.0
1,2-pentanediol 3.0
Part B purified water 20.0
Part C Neosolue-Aculio (Nippon Seika) 1.0
Glucosylceramide 0.5
Tremoist-TP (Nippon Seika) 0.1
EDTA-2Na 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 18 Moisturizing lotion

Component Blending amount (% by weight)
-------------------------------------
Part A Composite of Example 3 0.5
Diglycerin 1.0
Glycerin 8.0
1,2-pentanediol 4.0
Plandool-LG2 (Nippon Seika) 0.1
Plandool-ISS (Nippon Seika) 0.05
Polysorbate-20 0.3
Part B purified water 30.0
Part C Maltitol solution 1.0
Betaine 0.5
α-glucan oligosaccharide 0.1
Pullulan 0.5
Tuberose polysaccharide 0.01
Hydroxypropyl methylcellulose stearoxy ether 0.05
(Acrylates / alkyl acrylate (C10-30)) Crosspolymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, the mixture was dispersed with a high-pressure emulsifier (Microfluidizer manufactured by Mizuho Industries). After cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 19 Moisturizing lotion

Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.25
Phytopresome-MEL (Nippon Seika) 0.8
BG 5.0
Glycerin 10.0
1,2-hexanediol 3.0
Part B purified water 20.0
Part C Neosolue-AquaS (Nippon Seika) 1.0
PEG / PPG / polybutylene glycol-8 / 5/3 glycerol 0.5
Glucosyl trehalose 0.5
Polyquaternium-51 0.5
Acetyl hexapeptide-8 0.001
Rice bran ferment extract 1.0
Penteto acid 5Na 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 20 Moisturizing lotion

Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.2
Glycerin 8.0
Pentanediol 5.0
Lysolecithin 0.03
Cyclic lysophosphatidic acid Na 0.001
Part B purified water 20.0
Part C Hydrolyzed collagen 0.05
Citric acid 0.01
Na citrate 0.09
Neosolu-Aculio (Nippon Seika) 1.0
PPG-6 decyltetradeces-30 0.5
Apple fruit water 5.0
Bergamot peel oil 0.05
EDTA-2Na 0.05
Phenoxyethanol 0.4
Purified water Total amount of 100 ---------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 21 Moisturizing lotion

Component Blending amount (% by weight)
-------------------------------------
Part A Composite of Example 5 0.2
DPG 1.0
Glycerin 8.0
1,2-hexanediol 4.0
LUSPLAN PI-DA (Nippon Seika) 0.05
Plandool-DP (Nihon Seika) 0.05
Part B purified water 30.0
Part C Mannitol 1.0
PEG-30 1.0
Hydrolyzed collagen 0.1
Pullulan 0.5
Mucopolysaccharide 0.01
Hydroxyethyl cellulose 0.03
Carboxyvinyl polymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, the mixture was dispersed with a high-pressure emulsifier (Microfluidizer manufactured by Mizuho Industries). After cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 22 Whitening lotion

Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.5
Glycerin 8.0
1,3-propanediol 8.0
Part B VC ethyl (Nippon Seika) 1.0
Purified water 30.0
Ethanol 3.0
DPG 2.0
Methyl Gluces-10 2.0
Glycyrrhizic acid 2K 0.05
Tremoist-TP (Nippon Seika) 0.01
Xanthan gum 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid 0.1
Amount of sodium citrate in which the pH becomes 4.5 Part C Purified water Amount in total of 100 ----------------------------- ----------
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A and part C were each heated to 70 ° C., and part A was added while stirring part C with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part B mixed in advance was added to obtain a uniform liquid.

Example 23 Whitening lotion

Component Blending amount (% by weight)
---------------------------------------
Part A Composite of Example 3 0.5
1,2-pentanediol 3.0
Part B Tranexamic acid (Nippon Seika) 2.0
Phytic acid 0.30
Purified water 20.0
BG 5.0
Tripropylene glycol 2.0
DPG 2.0
Maltose 1.0
Carbomer 0.01
Glutamic acid 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid 0.1
Sodium citrate Appropriate part C Purified water Amount to be 100 in total ----------------------------------- -----
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A and part C were each heated to 70 ° C., and part A was added while stirring part C with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part B mixed in advance was added to obtain a uniform liquid.

Example 24 Gel lotion

Component Blending amount (% by weight)
-----------------------------------
Part A Composite of Example 3 0.25
Glycerin 10.0
1,2-pentanediol 3.0
Sorbitol solution (70%) 5.0
PEG-10 Dimethicone 0.4
Part B Glucose 1.0
DPG 3.0
Tripropylene glycol 3.0
Purified water 20.0
Part C Pullulan 0.2
Ethylhexyl glycerin 0.2
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Xanthan gum 0.05
Hyaluronic acid Na 0.01
Carbomer 0.06
Hydroxide K 0.05
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dispersed uniformly. Part C was mixed, stirred well, homogenized, and heated to about 70 ° C. Part B was stirred with a propeller to prepare a mixed solution. C part was added to A part, it stirred using the homomixer at about 70 degreeC, it cooled to about 40 degreeC, and the liquid mixture of B part was added.

Example 25 Transparent Gel

Component Blending amount (% by weight)
-------------------------------------
Part A Composite of Example 3 0.4
Glycerin 5.0
1,2-hexanediol 3.0
PPG-6 decyltetradeces-30 0.2
PEG-30 phytosterol 0.3
Phytopresome-MEL (Nippon Seika) 0.8
Purified water 30.0
Part B PEG-4M 0.2
Methyl Gluces-10 1.0
Pyridoxine hydrochloride 0.05
Ethylhexyl glycerin 0.2
Phenoxyethanol 0.4
Tremoist-TP (Nippon Seika) 0.01
Hydrolyzed collagen 0.01
Purified water Amount C to be 100 in total Pentate acid 5Na 0.05
(Ammonium dimethyltaurate acrylate / vinylpyrrolidone) Copolymer 0.05
(Acrylates / alkyl acrylate (C10-30)) cross polymer 0.15
Arginine 0.25
Purified water 30.0
---------------------------------------
(Preparation method)
Part A was stirred with a propeller to prepare a nano vesicle solution. Part C was mixed to obtain a viscous liquid. Part B was mixed to obtain a uniform liquid. Part A and part B were added to part C to make it uniform.

Example 26 Skull Proration

Component Blending amount (% by weight)
------------------------------------
Part A Composite of Example 3 0.3
Glycerin 4.0
1,2-pentanediol 2.0
Maltitol 0.5
PEG-60 hydrogenated castor oil 0.3
Part B purified water 50.0
Part C ethanol 10.0
Neosolute-AquaS (Nippon Seika) 2.0
Betaine 0.2
Hydroxypropyl chitosan solution 0.05
Carrot extract 0.1
Pyridoxine hydrochloride 0.05
Panthenol 0.1
Dipotassium glycyrrhizinate 0.1
Phenoxyethanol 0.3
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 27 Skull Proration

Component Blending amount (% by weight)
------------------------------------
Part A Composite of Example 3 0.3
Glycerin 6.0
1,2-hexanediol 1.0
Part B purified water 50.0
Part C Neosolue-Aculio (Nippon Seika) 1.0
Tocopherol acetate 0.05
Menthol 0.1
Betaine 0.2
Assembly extract 0.1
Japanese cypress rafji root extract 0.003
Hinokitiol 0.1
PCA-Na 0.1
Carbomer 0.01
Hydroxide K 0.01
Penteto acid 5Na 0.05
Methylparaben 0.1
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 28 Hair restorer

Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 2.0
Complex of Example 3 0.5
1,2-pentanediol 3.0
PEG-60 hydrogenated castor oil 0.3
Part B Betaine 0.5
Purified water 50.0
Part C ethanol 20.0
Menthol 0.1
Neosolute-AquaS (Nippon Seika) 2.0
Orange oil 0.05
Panthenyl ethyl ether 0.2
Glutamic acid 0.1
Polydimethyldimethylmethylenepiperidinium solution 0.1
Carrot extract 1.0
Clara extract 2.0
Chlorella extract 1.0
Trehalose 0.5
Nicotinamide 1.0
Piroctone olamine 0.1
Dipotassium glycyrrhizinate 0.1
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 29 Hair restorer

Component Blending amount (% by weight)
------------------------------------
Part A 1,2-hexanediol 2.0
Complex of Example 3 0.2
Phytopresome-MEL (Nippon Seika) 1.0
Part B Neosolu-Aquorio (Nippon Seika) 0.5
DPG 2.0
Lactic acid 0.1
Tremoist-TP (Nippon Seika) 0.01
Purified water 50.0
Part C ethanol 10.0
Menthol 0.1
Menthyl glyceryl ether 0.15
Panthenyl ethyl ether 0.2
Camphor 0.1
Cordyceps extract 1.0
Assembly extract 1.0
Loquat leaf extract 1.0
Hydrolyzed hyaluronic acid 0.02
Cyclic lysophosphatidic acid Na 0.001
Pepper extract 0.01
Betaine 0.3
Trehalose 0.2
Cymene-5-ol 0.1
Tocopherol acetate 0.05
β-glycyrrhetinic acid 0.05
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part B were each heated to 70 ° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare a nanovesicle solution. Further, after cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 30 Two-phase separation skin treatment

Component Blending amount (% by weight)
-------------------------------------
Part A Neosolute-MCT (Nippon Seika) 10.0
Squalane 24.0
Olive oil 24.0
Plandool-SUN (Nippon Seika) 2.0
Tocopherol acetate 0.1
Part B Composite of Example 3 0.2
1,2-pentanediol 3.0
Glycerin 8.0
Xanthan gum 0.02
NaCl 0.1
Benzoic acid Na 0.2
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. At about 50 ° C., part A and part B were added and stirred and cooled.

Example 31 Whitening emulsion

Component Blending amount (% by weight)
------------------------------------
Part A Plandool-DP (Nippon Seika) 1.0
Cetyl ethylhexanoate (Nippon Seika) 10.0
Cetanol 1.2
Dimethicone 100cs 3.0
Myristyl alcohol 2.0
Oleyl alcohol 1.0
Part B stearoxyhydroxypropylmethylcellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Composite of Example 3 0.2
Phytocompo-PP (Nippon Seika) 1.0
1,2-pentanediol 3.0
Glycerin 8.0
Part D 3-O-ethylascorbic acid (Nippon Seika) 1.0
Tranexamic acid (Nippon Seika) 2.0
Purified water 5.0
Part E Phenoxyethanol 0.2
Methylparaben 0.15
Phytic acid 0.5
Citric acid 0.1
Amount of Na citrate pH 4.5 Purified water Amount of total 100 100 ------------------------------- ------
(Preparation method)
Part A and part E were each heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was heated to about 70 ° C. and dispersed uniformly. After adding part A while stirring part C with a homodisper, part E was added while stirring. Part D and part B were added at about 50 ° C. and stirred to dissolve uniformly.

Example 32 Latex
Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 3.0
Diglycerin 1.0
BG 3.0
LP70H (Nippon Seika) 0.1
Phytocompo-PP (Nippon Seika) 1.5
Part B Triethylhexanoin (Nippon Seika) 3.0
LUSPLAN SR-DM4 (Nippon Seika) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Cetostearyl alcohol 1.0
Aralkyl alcohol 0.1
Jojoba alcohol 3.0
Kimyl alcohol 0.3
Serakil alcohol 0.1
Hexyldecanol 0.5
Part C Composite of Example 3 0.5
BG 5.0
(Hydroxyethyl acrylate / acryloyl dimethyltaurine Na) copolymer 0.2
Tremoist-TP (Nihon Seika) 0.03
Carbomer 0.1
Purified water 30.0
Part D Neosolue-AquaS (Nippon Seika) 0.5
Polyquaternium-51 1.0
Ascorbyl glucoside 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A, part B and part D were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part C was mixed and stirred to obtain a liposome solution. After adding part B while stirring part A with a homodisper, part D was added and emulsified. C. Part C was added at about 50.degree. C. and the mixture was stirred and cooled to about 40.degree.

Example 33 Skin Care Cream

Component Blending amount (% by weight)
------------------------------------
Part A Composite of Example 3 0.5
Glycerin 9.0
DPG 5.0
Tripropylene glycol 2.0
Phytocompo-PP (Nippon Seika) 1.0
Part B (C13-15) Alkane 8.0
Vaseline 10.0
Pentaerythrityl tetraisostearate5.0
Astaxanthin 0.01
Cetyl PG hydroxyethyl palmitamide 0.05
Cyclic lysophosphatidic acid Na 0.01
Dipentaerythrityl hexahydroxystearate1.0
Part C Carbomer 0.1
Hydroxide K 0.07
Xanthan gum 0.1
Purified water 10.0
Part D Phenoxyethanol 0.4
Ethylhexyl glycerin 0.2
Methylparaben 0.05
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A, part B and part D were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. C. Part C was added at about 50.degree. C. and the mixture was stirred and cooled to about 40.degree.

Example 34 Skin Care Cream

Component Blending amount (% by weight)
------------------------------------
Part A Sugar Squalane 10.0
Stearic acid 1.0
Plandool-ISS (Nippon Seika) 1.0
Macadamia nut oil 3.0
Hydrogenated rapeseed oil alcohol 2.0
Olive oil fatty acid cetearyl 1.0
Olive oil fatty acid sorbitan 0.8
Polyglyceryl oleate-10 1.0
Part B Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.07
(Ammonium acryloyldimethyltaurate /
Methenic acid behenes-25) Cross polymer 0.2
Tremoist-SL (Nippon Seika) 1.0
Purified water 20.0
Hydrolyzed polyγ-glutamic acid K 0.1
Polyglutamate Na 0.1
Oligopeptide-24 0.05
Part C composite of Example 5 0.5
Glycerin 9.0
Propanediol 10.0
PEG-8 5.0
PEG-2M 2.0
Glyceryl caprylate0.8
1,2-pentanediol 1.5
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part C were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part B was mixed and stirred to give a viscous liquid. While stirring part C with a homomixer, part A was added and emulsified. Cooled to about 50 ° C., part B was added, stirred and cooled to about 40 ° C.

Example 35 Skin Care Cream

Component Blending amount (% by weight)
------------------------------------
Part A Composite of Example 3 0.5
Plandool-MAS (Nippon Seika) 2.0
Plandool-LG1 (Nippon Seika) 1.0
Paraffin wax 3.0
Shea Butter 3.0
Squalane 8.0
Cetanol 1.8
Hydrogenated cocoglyceryl 0.8
Glyceryl stearate 1.0
Behenyl alcohol 1.5
Sorbitan stearate 1.0
Polyglyceryl laurate-10 1.0
PEG-60 glyceryl isostearate 1.0
Methyl glucose sesquistearate1.5
Part B xanthan gum 0.1
Hydroxyethyl cellulose 0.1
Crystalline cellulose powder 0.3
Stearoxyhydroxypropylmethylcellulose 0.1
Tranexamic acid 0.5
Purified water 20.0
Part C Glycerin 8.0
DPG 5.0
Sorbitol 2.0
Neosolu-Aculio (Nippon Seika) 1.0
Methylparaben 0.15
Purified water Total amount of 100 ------------------------------------
(Preparation method)
Part A and part C were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part B was mixed and stirred to give a viscous liquid. While stirring part C with a homomixer, part A was added and emulsified. Cooled to about 50 ° C., part B was added, stirred and cooled to about 40 ° C.

Example 36 Skin Care Cream

Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 9.0
Phytocompo-C (Nippon Seika) 1.0
Glucosyl rutin 0.001
Part B Argania spinosa kernel oil 1.0
Theobroma grunge flour seed fat 1.0
Astaxanthin 0.005
Pentaerythrityl tetraethylhexanoate (Nippon Seika) 0.1
Ethyl hexyl stearate 3.0
Plandool-ISS (Nippon Seika) 2.0
Sucrose stearate 1.0
Carnauba 0.5
Steareth-2 2.5
Steareth-21 1.8
Cetanol 3.0
Tocopherol acetate 0.03
Squalane 3.0
Part C Composite of Example 3 0.5
1,2-pentanediol 2.0
Carbomer 0.1
Arginine 0.1
Hydroxypropyl chitosan 0.2
Ethanol 3.0
Purified water 10.0
Panthenol 0.5
Retinol palmitate 0.05
Part D Methylparaben 0.15
Purified water Amount to be 100 in total
(Preparation method)
Part A, part B and part D were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. C. Part C was added at about 50.degree. C. and the mixture was stirred and cooled to about 40.degree.

Example 37 Skin Care Cream

Component Blending amount (% by weight)
------------------------------------
Part A Glycerin 12.0
BG 3.0
Phytocompo-PP (Nippon Seika) 2.5
Part B Olive fruit oil 3.0
Olive oil 1.5
Shea fat 1.0
Pentaerythrityl tetraethylhexanoate (Nippon Seika) 3.0
Sucrose stearate 0.8
Cetearyl glucoside 1.2
Behenyl alcohol 1.5
Ascorbyl tetrahexyldecanoate 7.0
Lauroyl sarcosine isopropyl 2.0
Hydrogenated cocoglyceryl 3.0
Cetanol 2.5
Sorbitan stearate 0.8
Part C Composite of Example 3 0.2
Purified water 20.0
1,2-hexanediol 2.0
Part D Xanthan gum 0.05
Tremoist-SL (Nippon Seika) 1.0
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
Pyrosulfite Na 0.03
Arbutin (Nippon Seika) 1.0
Tranexamic acid (Nippon Seika) 1.0
Purified water 10.0
Part E Neosolue-Aculio (Nippon Seika) 1.0
Propanediol 3.0
Methylparaben 0.1
Glyceryl caprylate 1.0
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A, part B and part E were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part D was mixed and stirred to give a viscous liquid. Part C was heated and mixed to about 70 ° C. to prepare liposomes. After adding part B while stirring part A with a homodisper, part E was added and emulsified. C. and D parts were added at about 50.degree. C., and the mixture was stirred and cooled to about 40.degree.

Example 38 Skin Care Cream

Component Blending amount (% by weight)
-----------------------------------
Part A diisostearyl malate (Nippon Seika) 5.0
Jojoba oil 2.0
Plandool-H (Nippon Seika) 1.0
Neosolute-MCT (Nippon Seika) 3.0
LUSPLAN DD-DHR (Nippon Seika) 1.0
Plandool-SUN (Nippon Seika) 1.3
Propylene glycol stearate 0.6
Squalane 3.0
Behenyl alcohol 2.0
Ethylparaben 0.1
Liquid isoparaffin 0.5
Carnauba wax 0.3
Corn oil 0.3
Rapeseed oil 1.0
Sunflower oil 1.0
Wheat germ oil 1.0
Linseed oil 0.1
Cottonseed oil 0.1
Soybean oil 0.1
Shea fat 0.5
Stigmasterol 1.0
Stigmasterol 1.0
Dihydrocholesterol 0.1
Lanosterol 0.1
Dihydrolanosterol 0.1
Cholesteryl nonanoate 0.1
Cholesteryl stearate 0.1
Cholesteryl isostearate 1.0
Cholesteryl oleate 0.1
Cholesteryl 12-hydroxystearate 0.1
Long-chain branched fatty acid cholesteryl 0.3
Octyldodecyl myristate 1.0
Octyldodecyl isostearate 1.0
Daimerlinoleic acid hydrogenated castor oil 1.0
Hydroxyalkyl dimer linoleyl ether 1.0
Tetra (hydroxystearic acid / isostearic acid)
Dipentaerythrityl 0.5
Rice bran oil fatty acid phytosteryl 0.5
Phenyltrimethicone 1.0
Diphenyl dimethicone 1.0
Methyl hydrogen polysiloxane 1.0
Polyglyceryl-3 polydimethylsiloxyethyl dimethicone 0.5
Sugar-modified silicone 0.3
Polyoxyethylene methylpolysiloxane copolymer 1.0
Tocopherol ferulate 0.1
Tocopherol phosphate 0.1
Tocotrienol 0.1
Tannin 0.01
Sesamin 0.01
Proanthocyanidins 0.01
Grab lysine 0.01
Grablen 0.01
Liquiritin 0.01
Isoliquitin 0.01
Lactoferrin 0.01
Gingerall 0.01
Gingerol 0.01
Part B (acryloyldimethyltaurine /
Methenic acid behenes-25) copolymer 0.2
Crystalline cellulose 0.1
Gellan gum 0.1
Carboxyvinyl polymer 0.1
Hydroxide K 0.08
Purified water 20.0
Part C Phytocompo-PP (Nippon Seika) 1.0
Complex of Example 3 0.3
Polyglyceryl stearate-10 0.5
Lysolecithin 0.05
Hydrogenated egg yolk lecithin 0.1
Glycerin 7.0
DPG 7.0
Part D Citric acid 0.07
Sodium citrate appropriate amount EDTA-2Na 0.05
Penteto acid 5Na 0.03
Phenoxyethanol 0.4
Purified water Amount to be 100 in total
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed, heated to about 70 ° C., and dispersed uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. Part A was added to part C while stirring with a homogenizer, and part D was added to emulsify. At about 50 ° C., part B was added and stirred to dissolve uniformly.

Example 39 Skin Care Cream

Component Blending amount (% by weight)
--------------------------------
Part A Plandool-G (Nippon Seika) 1.0
Neosolu-Aculio (Nippon Seika) 1.5
Diethylhexyl sebacate (Nippon Seika) 8.0
Diisopropyl sebacate (Nippon Seika) 2.0
Theobroma Grange Flora Seed Fat 3.0
Batyl isostearate 2.0
Shea fat 3.0
Isostearyl pivalate 0.1
Pentaerythrityl tetraethylhexanoate (Nippon Seika) 0.1
Stearyl alcohol 3.5
Cetanol 1.3
Hydrogenated lecithin 0.5
Palm fatty acid sucrose 1.0
Polyglyceryl distearate-3-methylglucose 0.8
Tri-Fatty Acid (C10-18) Glyceryl 3.0
Squalane 3.0
Dimethicone 100cs 1.0
Tocopherol 0.1
Ascorbyl tetrahexyldecanoate 8.0
Tocopheryl ascorbyl phosphate 2.0
Placenta extract 1.0
Oryzanol 0.3
Phytosphingosine 0.0001
Ubiquinone 0.03
Carotene 0.05
Lycopene 0.01
Astaxanthin 0.01
Lutein 0.01
Fullerene 0.001
Peanut oil 0.1
Rice bran oil 1.0
Hydrogenated castor oil 0.3
Jojoba oil 2.0
Orange Raffy Oil 1.0
Liquid lanolin (Nippon Seika) 1.0
Lanolin (Nippon Seika) 1.0
Polyoxyethylene lanolin 1.0
Lanolin alcohol (Nippon Seika) 0.3
Lanolin acetate 0.1
Cholesteryl acetate 0.1
Octocrylene 0.5
Sorbitan sesquistearate1.2
Part B Tremoist-TP (Nippon Seika) 0.05
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
2-Methacryloyloxyethyl phosphorylcholine
Butyl methacrylate copolymer solution 0.05
Glutathione 0.3
Butyl resorcinol 1.5
Arbutin (Nippon Seika) 3.0
Ascorbyl phosphate Mg 1.0
Part C Composite of Example 3 0.2
Propanediol 10.0
PPG-9 Diglyceryl 2.0
Diglycerin 1.0
Pyrosulfite Na 0.1
Imidazolinium urea 0.1
Polyvinylpyrrolidone 0.1
Pullulan 0.1
Polyvinyl alcohol 0.1
Dehydroacetic acid 0.1
PEG-32 1.0
Polyglycerin-10 1.0
Penteto acid 5Na 0.05
Phenoxyethanol 0.4
1,2-pentanediol 2.0
Succinic acid, Na succinate Appropriate amount Purified water Amount to be 100 in total ----------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was made uniform using some purified water. Part C was heated to about 70 ° C. and dispersed. While stirring with a homomixer at about 70 ° C., part A was gradually added to part C to emulsify. After cooling to about 40 ° C., part B was added and mixed uniformly.

Example 40 Hand Cream
Component Blending amount (% by weight)
--------------------------------
Part A Complex of Example 3 1.0
Lanolin Fatty Acid Cholesteryl (Nippon Seika) 5.0
LUSPLAN SR-DM4 (Nippon Seika) 0.1
Squalane 8.0
Macadamia nut oil 0.5
Rosehip oil 1.0
Meadow Foam Oil 1.0
Vaseline 15.0
Microcrystalline wax 2.0
Glyceryl stearate 2.0
Cetanol 2.0
Cetyl phosphate 1.0
Beeslow 3.0
Tocopherol 0.05
Perfluoropolyether 1.0
Part B Glycerin 8.0
Propanediol 5.0
Na propionate 0.1
Ethylhexyl glycerin 0.5
Phenoxyethanol 0.3
Hydroxide Na 0.5
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part B was heated to about 70 ° C. and dissolved. Part A was taken in another container and heated to about 80 ° C. to dissolve. A part A was added to part B while stirring with a homomixer and emulsified. After emulsification, it was cooled to about 40 ° C.

Example 41 Hand Cream

Component Blending amount (% by weight)
--------------------------------
Part A Plandool-G (Nippon Seika) 0.5
(Dimethicone / vinyl dimethicone) Cross polymer 0.3
(Vinyl Dimethicone / Lauryl Dimethicone) Cross Polymer 0.5
(Dimethicone / PEG-10 / 15) Crosspolymer 0.5
(PEG-15 / Lauryl Dimethicone) Cross Polymer 0.2
(Alkyl acrylate / dimethicone) copolymer 0.1
Cetyl ethylhexanoate (Nippon Seika) 10.0
Squalane 5.0
Dodecane 3.0
Part B Composite of Example 3 0.2
Diglycerin 5.0
1,2-pentanediol 2.0
Part C Xanthan gum (2% aqueous solution) 6.0
(Acrylamide / ammonium acrylate) copolymer 0.5
Phenoxyethanol 0.6
Water Total amount of 100 --------------------------------
(Preparation method)
After part B was dissolved, part A was added and heated to about 70 ° C. (part D). Part C was brought to about 70 ° C. C part was added to D part with stirring, and stirred and mixed with a homomixer for about 3 minutes. After mixing uniformly, it was cooled to about 40 ° C.

Example 42 Hand Cream

Component Blending amount (% by weight)
--------------------------------
Part A Squalane 10.0
Vaseline 20.0
Polyglyceryl pentastearate-10 2.0
Polyglyceryl polyricinoleate-10 1.5
Microcrystalline wax 4.0
Stearoyl lactate Na 1.3
Stearic acid Al 1.5
Stearic acid Mg 1.0
Stearic acid Ca 0.1
Part B Plandool-MAS (Nippon Seika) 1.0
Plandool-DP (Nippon Seika) 0.8
Cetyl ethylhexanoate (Nippon Seika) 5.0
Ethylhexanoin (Nippon Seika) 6.0
Propylparaben 0.05
Tocopherol 0.05
Dimethicone 5cs 5.0
Part C Composite of Example 3 0.2
Methylparaben 0.1
1,2-pentanediol 3.0
Glycerin 10.0
Water Total amount of 100 --------------------------------
(Preparation method)
Part B and part C were each heated to about 80 ° C. and dissolved. Part A was taken in another container, heated to 100-120 ° C., turned into a transparent gel, and cooled to 80 ° C. Part B was added to part A with stirring, and part C was added and emulsified. After mixing uniformly, it was cooled to about 40 ° C.

Example 43 Latex

Component Blending amount (% by weight)
---------------------------------
Part A Phytocompo-SP (Nippon Seika) 10.0
LP70H (Nippon Seika) 0.1
Complex of Example 3 0.2
Part B Squalane 4.0
Neosolute-MCT (Nippon Seika) 4.0
α-Olefin oligomer 2.5
Dimethicone 5cs 3.5
Cetanol 1.5
Glyceryl stearate 1.0
Part C Hydroxyproline 0.05
Citric acid 0.01
Na citrate 0.09
Arbutin (Nippon Seika) 3.0
Phenoxyethanol 0.3
Methylparaben 0.1
Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.1
Purified water Total amount of 100 ----------------------------------
(Preparation method)
A part to C part were taken, heated to about 70 ° C., and mixed uniformly. After gradually adding B part to A part with stirring with homodisper, C part was added and emulsified at about 70 ° C. Thereafter, it was cooled to about 40 ° C.

Example 44 Cleansing Gel

Component Blending amount (% by weight)
--------------------------------
Part A Composite of Example 3 0.5
1,2-pentanediol 1.0
Cetyl ethylhexanoate (Nippon Seika) 10.0
Plandool-S (Nippon Seika) 1.0
Bell Paul DC-30 (Nippon Seika) 2.0
LUSPLAN DD-IS (Nippon Seika) 8.0
PEG-25 hydrogenated castor oil 20.0
Octyldecess-20 15.0
Glycerin 16.0
BG 5.0
Part B Phenoxyethanol 0.5
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was warmed to about 80 ° C. While stirring, part B was gradually added to part A, and cooled to 40 ° C. after mixing.

Example 45 Cleansing Cream

Component Blending amount (% by weight)
--------------------------------
Part A Plandool-LG2 (Nippon Seika) 1.0
Neosolu-Aculio (Nippon Seika) 1.0
Ceresin 6.0
Complex of Example 3 0.5
PEG-12 isostearic acid 3.0
Sorbitan sesquioleate 1.5
Oleic acid polyoxyethylene sorbitan 0.3
Polyglyceryl laurate-10 0.3
Microcrystalline wax 2.0
Tocopherol 0.05
Part B Neosole-Aqua (Nippon Seika) 0.5
DPG 5.0
Edetic acid 3Na 0.02
Phenoxyethanol 0.5
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was warmed to about 80 ° C. While stirring, part B was gradually added to part A, and cooled to 40 ° C. after mixing.

Example 46 Cleansing Balm

Component Blending amount (% by weight)
------------------------------------
Ethyl hexyl palmitate (Nippon Seika) Total amount of 100 Cetyl ethyl hexanoate (Nippon Seika) 10.0
Complex of Example 5 0.5
Plandool-LG3 (Nippon Seika) 0.2
Plandool-S (Nippon Seika) 0.5
PEG-20 glyceryl triisostearate 14.0
Polyglyceryl laurate-10 0.5
Polyethylene 5.5
Microcrystalline wax 2.0
Phenoxyethanol 0.5
Tocopherol 0.05
------------------------------------
(Preparation method)
All ingredients were mixed with stirring at about 90 ° C. until uniform.

Example 47 Cleansing Oil

Component Blending amount (% by weight)
--------------------------------
Complex of Example 3 0.5
Neosolu-Aquilio (Nippon Seika) 2.0
Cetyl ethylhexanoate (Nippon Seika) 9.0
Mineral oil 14.0
Isododecane 5.0
Decamethylcyclopentasiloxane 10.0
Glycerin 16.0
BG 5.0
Ethanol 5.0
PEG-8 glyceryl isostearate 14.0
Palm oil fatty acid PEG-7 glyceryl 14.0
Polyglyceryl diisostearate-2 1.5
EDTA-2Na 0.1
Citric acid 0.01
Na citrate 0.09
Purified water Total amount of 100 --------------------------------
(Preparation method)
All ingredients were stirred and mixed until uniform at room temperature.

Example 48 Face Wash Foam

Component Blending amount (% by weight)
----------------------------------
Part A Stearic acid K 10.0
Palmitic acid K 10.0
Myristic acid K 10.0
Lauric acid K 4.0
Lauroyl sarcosine isopropyl 0.8
Complex of Example 3 0.5
PEG-150 10.0
Glycerin 15.0
Glyceryl monostearate1.0
POE (20) sorbitan monostearate 2.0
Part B Tremoist-SL (Nippon Seika) 1.0
Polyquaternium-7 0.5
Polyquaternium-39 0.5
Methylparaben 0.1
Purified water Total amount of 100 ----------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was warmed to about 80 ° C. While stirring, part B was gradually added to part A, and cooled to 40 ° C. after mixing.

Example 49 Face Washing Foam

Component Blending amount (% by weight)
--------------------------------
Part A Composite of Example 3 0.5
(Coconut fatty acid / hydrogenated beef tallow fatty acid) glutamic acid Na 30.0
Cocoyl Glycine K 5.0
Plandool-LG2 (Nippon Seika) 0.2
Lauric acid diethanolamide 3.0
Tocopherol 0.1
PEG-8 5.0
PEG-32 10.0
Glycerin 14.0
Part B Glyceryl caprylate 1.0
Hexanediol 1.0
Polyquaternium-51 1.0
Tremoist-SL (Nippon Seika) 0.5
Crystalline cellulose 0.3
Polyquaternium-7 0.8
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was warmed to about 80 ° C. While stirring, part B was gradually added to part A, and cooled to 40 ° C. after mixing.

Example 50 Body Shampoo

Component Blending amount (% by weight)
--------------------------------
Complex of Example 3 0.5
Cocoyl Methyl Taurine Na 10.0
Lauroyl hydrolyzed silk Na 6.0
Lauroylmethylalanine Na 10.0
Cocoamphoacetate Na (30%) 4.0
Cocamidopropyl betaine (30%) 10.0
Olefin (C14-16) sulfonic acid Na 5.0
Polyquaternium-10 1.3
Guar hydroxypropyltrimonium chloride 0.8
Acetyl hyaluronic acid Na 0.02
Cocamide DEA 3.0
Glycerin 5.0
Methylparaben 0.2
Purified water Total amount of 100 --------------------------------
(Preparation method)
All components were warmed at about 80 ° C. and stirred and mixed uniformly.

Example 51 Non-silicone shampoo

Component Blending amount (% by weight)
--------------------------------
Complex of Example 3 0.5
Plandool-LG2 (Nihon Seika) 0.03
Neosolute-AquaS (Nippon Seika) 0.1
Tremoist-SL (Nippon Seika) 0.5
Laureth-4 carboxylic acid Na (28%) 10.0
Laureth-6 carboxylic acid 4.0
Cocamidopropyl betaine (30%) 10.0
Lauroylmethylalanine Na (30%) 5.0
Cocamidomethyl MEA 3.0
Palm oil fatty acid PEG-7 glyceryl 5.0
Hydroxyl Na 1% solution 0.5
Polyquaternium-10 0.8
Distearate glycol 0.5
Polyquaternium-7 0.5
EDTA-2Na 0.05
Phenoxyethanol 0.4
Benzoic acid Na 0.2
Purified water Total amount of 100 --------------------------------
(Preparation method)
All components were warmed at about 80 ° C. and stirred and mixed uniformly.

Example 52 Hand Soap

Component Blending amount (% by weight)
-------------------------------
Part A Cocoyl Isethionate Na 1.0
Glycerin 50.0
Complex of Example 3 0.5
Part B Lauroyl Sarcosine Na 12.0
Myristoyl methyl taurine sodium 2.0
Polyglyceryl laurate-6 2.0
Palm oil fatty acid diethanolamide 2.0
PEG-7 palm oil fatty acid glyceryl 2.0
Synthetic latex 0.1
Nitrocellulose 0.1
Sorbitol 8.0
Hydrolyzed conchiolin 0.1
1,3-butylene glycol 8.0
Phenoxyethanol 0.8
Ethanol 3.0
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was added to part A, heated to about 80 ° C. to dissolve uniformly, and then cooled.

Example 53 Hair treatment without washing off

Component Blending amount (% by weight)
------------------------------------
Part A Composite of Example 3 0.5
Polyquaternium-37 2.0
Squalane 2.0
PPG-3 caprylyl ether 2.0
Microcrystalline wax 0.1
Lanolin alcohol 0.2
Montan wax 0.1
Polyethylene wax 0.1
Owl 0.2
Ceresin 0.1
Dicapric acid PG 1.0
Almond oil 0.5
Ethylhexyl ethylhexanoate 1.0
Candelilla wax extract 0.1
Octyldodecyl erucate 4.5
Tocopherol acetate 0.02
Elcalactone MCT (Nippon Seika) 2.0
Dipentaerythrityl tripolyhydroxystearate1.5
PPG-5 phytosteryl 0.5
Glycerin 4.0
Sorbitol 2.0
Phenoxyethanol 0.5
Part B Hydrolyzed hyaluronic acid 0.1
Panthenol 0.1
Hydroxypropyltrimonium hyaluronate 0.01
Polyquaternium-11 0.2
Glycosyl trehalose 0.1
Glyceryl glucoside 0.3
Arginine 0.1
Part C Purified water Total amount of 100 Hydroxypropyl starch phosphate 1.0
------------------------------------
(Preparation method)
Part C was uniformly dispersed and heated to about 80 ° C. Next, part A was heated to about 80 ° C. and dissolved. Part A was added with stirring, part A was mixed uniformly, and then cooled to about 40 ° C. Subsequently, each B part was added and mixed uniformly.

Example 54 Scalp / Hair Treatment Without Washing
Component Blending amount (% by weight)
------------------------------------
Part A Composite of Example 3 0.5
Neosolu-Aculio (Nippon Seika) 1.0
Ethanol 40.0
Glycyrrhetinic acid 0.02
Elcalactone DES (Nippon Seika) 1.5
PEG / PPG-20 / 20 dimethicone 0.2
PEG-12 Dimethicone 0.4
Hydrogenated retinol 0.1
Tridohexyl decanoate pyridoxine 0.05
Bisglyceryl ascorbic acid 0.3
Hexyl 3-glyceryl ascorbic acid 0.3
Part B Triethanolamine 0.1
Purified water Total amount of 100 (Acrylates / alkyl acrylate (C10-30)) Crosspolymer 0.4
Carbomer 0.05
Tremoist-SL (Nippon Seika) 1.0
(Acryloyldimethyltaurate ammonium / VP) copolymer 0.05
(Acryloyldimethyltaurate ammonium / methacrylic acid beheneth-25) cross polymer 0.1
Hydroxypropyl chitosan 0.1
Methylparaben 0.1
Phenoxyethanol 0.2
Part C 3-O-ethylascorbic acid (Nippon Seika) 0.3
Nicotinamide 0.3
Pyridoxine hydrochloride 0.1
Caffeine 0.1
Glucosyl trehalose 0.1
Purified water 10.0
---------------------------------------
(Preparation method)
Part A was heated to about 50 ° C. and dissolved. Next, part B was uniformly dispersed to obtain a viscous liquid. Part A was added to part B with stirring and mixed uniformly. Next, part C was added and mixed uniformly.

Example 55 Non-silicone hair treatment

Component Blending amount (% by weight)
------------------------------------
Part A Plandool-LG2 (Nippon Seika) 0.5
Propanediol 3.0
Behenamidopropyldimethylamine 1.5
Cetanol 2.2
Stearyl alcohol 0.8
Hydrogenated rapeseed oil alcohol 0.5
Neopentyl glycol diethylhexanoate 0.8
Jojoba seed oil 1.0
Isododecane 1.0
Glyceryl stearate 0.4
Propylparaben 0.1
Cocamidomethyl MEA 0.8
Caesarpinia spinosa hydroxypropyltrimonium chloride 0.1
Rice bran wax 0.5
Glycerin 1.0
Part B Composite of Example 3 0.2
1,2-pentanediol 3.0
Purified water 20.0
Part C Phenoxyethanol 0.4
Tremoist-SL (Nippon Seika) 1.0
Lactic acid 0.4
Purified water Amount to be 100 in total
(Preparation method)
Part A and part C were mixed uniformly at about 80 ° C., respectively. Part B was uniformly dispersed at about 70 ° C. C. Part C was gradually added to part A with stirring and mixed uniformly, and then cooled to about 50.degree. Part B was added and mixed uniformly.

Example 56 Dandruff Shampoo

Component Blending amount (% by weight)
-----------------------------------
Part A Composite of Example 5 0.2
Lauroylmethylalanine Na (30%) 13.0
Cocamidopropyl betaine (30%) 20.0
Cocoa glutamic acid TEA (30%) 5.0
Cocamide DEA 1.0
Glycerin 1.0
Glyceryl caprylate 0.4
Glyceryl undecylenate 0.1
Neosolute-AquaS (Nippon Seika) 1.0
Sorbitol 1.6
Miconazole nitrate 0.75
Distearate glycol 1.5
Polyquaternium-7 0.3
Part B: Benzoic acid Na 0.4
Na chloride 0.2
Purified water Total amount of 100 parts C assembly extract 3.0
Polyquaternium-10 0.2
Guar hydroxypropyltrimonium chloride 0.1
Polyquaternium-47 0.1
Piroctone olamine 0.1
Purified water 9.7
-----------------------------------
(Preparation method)
Part B was heated to about 80 ° C. and dissolved uniformly. Part A was taken in a separate container, heated and dissolved. Part B was gradually added to part A, mixed uniformly, and part C was added at about 60 ° C.

Example 57 Shampoo
Component Blending amount (% by weight)
---------------------------------
Part A Composite of Example 3 0.2
PPG-3 caprylyl ether 0.2
Ammonium laureth sulfate 5.0
Laureth sulfate Na (25%) 10.0
Lauryl hydroxysultain (30%) 10.0
Lauric acid K 1.0
Distearate glycol 0.5
Toluenesulfonic acid 0.3
Stearoxypropyldimethylamine 0.5
PPG-17 0.3
Dimethicone 0.1
PEG-9 dimethicone 0.1
Amodimethicone 0.1
Diethylhexyl sebacate (Nippon Seika) 1.0
Neopentyl glycol diethylhexanoate 0.4
Lanolin fatty acid 0.3
Isodecyl glyceryl ether 0.4
Miconazole nitrate 0.75
Cocamide MEA 1.0
Laureth-4 0.3
Laureth-16 0.2
Steerless-6 0.2
Phenoxyethanol 0.3
Part B Malic acid 0.1
Methylparaben 0.2
Phosphoric acid 0.03
Benzoic acid Na 0.3
Purified water Total amount of 100 parts C Polyquaternium-10 0.2
Guar hydroxypropyltrimonium chloride 0.1
Tremoist-SL (Nippon Seika) 3.0
Purified water 6.7
---------------------------------
(Preparation method)
Part A was uniformly mixed at about 80 ° C. Part B, which was set aside, was heated to about 60 ° C. and made uniform. The part B was gradually added to the part A with stirring and mixed uniformly, and then cooled to about 50 ° C. Furthermore, C part was added and mixed uniformly.

Example 58 Leave-On Hair Treatment

Component Blending amount (% by weight)
---------------------------------
Part A Composite of Example 3 0.2
Neosolu-Aquilio (Nippon Seika) 2.0
Cetrimonium chloride (25%) 3.8
Caprylyl glucoside (50%) 0.8
Glycerin 4.0
Phenoxyethanol 0.5
Part B Ethanol 5.0
Part C Polyquaternium-6 0.6
Polyquaternium-7 0.4
Polyquaternium-39 0.5
Purified water Total amount of 100 ---------------------------------
(Preparation method)
Part C was heated to about 80 ° C. and dissolved. Next, part A was heated to about 80 ° C. and dissolved. Part A was added with stirring, part A was mixed uniformly, and then cooled to about 40 ° C. Next, part B was added and mixed uniformly.

Example 59 Hair Mousse

Component Blending amount (% by weight)
--------------------------------
Complex of Example 3 0.2
Ethanol 5.0
Polyethylene glycol oleyl ether (20) 1.0
Acrylic resin alkanolamine solution 3.0
Stearic acid diethylaminopropylamide 0.5
Pyrrolidone carboxylic acid 0.2
Preservatives, fragrance 1.0
Purified water Total amount of 100 --------------------------------
(Preparation method)
The above components were mixed, and the obtained base and LPG were mixed at a ratio of base: LPG = 92: 8 to obtain an injection-type mousse.

Example 60 Hair Color Treatment

Component Blending amount (% by weight)
------------------------------------
Part A Composite of Example 3 0.3
Neosolu-Aculio (Nippon Seika) 1.0
Steartrimonium chloride (70%) 2.5
Quotanium-33 (cation NH: Nippon Seika) 0.3
Cocamide DEA 1.0
Inulin stearate 0.5
Lanolin alcohol 0.2
Montan wax 0.1
Polyethylene wax 0.1
Beeswax 0.1
Dextrin palmitate 0.3
Ceresin 0.1
Capric acid PPG-3 1.0
Dicapric acid PG 1.0
Ethylhexyl ethylhexanoate 1.0
Dicaprylyl carbonate 1.5
Glycerin 4.0
Setes-7 1.0
Isostearyl alcohol 0.3
Rice bran oil 0.5
Glyceryl stearate 0.5
Elcalactone DES (Nippon Seika) 1.5
Hydrogenated polydecene 0.1
Macadamia nut fatty acid ethyl 1.0
Dilauroyl glutamate lysine Na 0.1
Behendimonium ethyl stearyl phosphate 0.1
Tocopherol 0.05
Phenoxyethanol 0.3
Part C purified water 10.0
BG 2.0
Acylated hydrolyzed collagen 0.1
Panthenol 0.1
Hydroxyethyl cellulose 0.1
Polyquaternium-64 0.1
Polyquaternium-51 0.01
Polyquaternium-49 0.2
Phenoxyethanol 0.4
PCA-Na 0.1
Part D Purified water Total amount of 100 Basic Blue 99 0.1
Basic tea 16 0.13
HC Blue 2 0.05
HC yellow 2 0.03
HC red 3 0.1
Hydroxyethylurea 0.5
Arginine 0.2
Ammonium bicarbonate 1.0
------------------------------------
(Preparation method)
Part A, which had been uniformly mixed in advance, was added to part B and heated to about 80 ° C. to dissolve (part E). In a separate container, part D was heated to about 80 ° C. and dissolved. While stirring D part to E part, it was gradually added and mixed uniformly and then rapidly cooled (part F). C part was added to F part which became about 40 ° C. to make it uniform.

Example 61 Hair nail polish
Component Blending amount (% by weight)
------------------------------------
Part A Composite of Example 3 0.2
Ethanol 10.0
Carnauba wax 0.01
Setes-10 1.0
Elcalactone DES (Nippon Seika) 2.5
PPG-3 caprylyl ether 1.0
Capric acid PPG-3 0.5
Dicapric acid PG 0.5
Dicaprylyl carbonate 0.5
B part purple 401 0.2
Black 401 0.1
Orange 205 0.1
Red 102 0.1
Citric acid 2.0
Benzyl alcohol 8.0
Ethanol 10.0
Part C Purified water Amount of total 100 (Ammonium acryloyldimethyltaurate / VP) Copolymer 3.0
Glycolic acid 2.0
Hydroxypropyl xanthan gum 0.2
------------------------------------
(Preparation method)
A part and C part were mixed and made uniform. After stirring to part B and adding to part C and mixing uniformly, part A was added at about 60 ° C. and mixed uniformly.

Example 62 Hair Oil

Component Blending amount (% by weight)
--------------------------------
Complex of Example 3 0.2
Neosolue-DE (Nippon Seika) 10.0
Diethylhexyl sebacate (Nippon Seika) 10.0
Neosolute-MCT (Nippon Seika) 20.0
Tocopherol 0.1
Propylparaben 0.1
Isododecane 5.0
Decamethylcyclopentasiloxane 5.0
Dimethicone 2cs Total amount of 100 --------------------------------
(Preparation method)
All ingredients were dissolved by heating and mixed.

Example 63 Lipstick

Component Blending amount (% by weight)
--------------------------------
Complex of Example 3 0.2
LUSPLAN SR-DP4 (Nippon Seika) 7.0
Hydrogenated polyisobutene 5.0
Triethylhexanoin (Nippon Seika) 10.0
Neosolue-MCT (Nippon Seika) Total amount of 100 Dialkyl carbonate (C14, 15) 3.0
Dextrin palmitate 0.9
Stearoyl lactate Na 0.9
Cetyl ethylhexanoate (Nippon Seika) 24.0
Dimethicone 50cs 5.0
Plandool-MAS (Nippon Seika) 2.0
Ceresin 8.5
Candelilla Row 4.0
Sorbitan sesquioleate 0.15
Hydrogen Dimethicone 2.0
Ethanol 0.1
Tocopherol 0.5
Nylon-12 2.0
(Ethylene / Propylene) Copolymer 0.5
Sulfuric acid Ba 1.0
Iron oxide 2.0
Mica 2.0
Titanium oxide 1.0
--------------------------------
(Preparation method)
After all the components were uniformly heated and stirred, they were filled in a mold and rapidly cooled.

Example 64 Lipstick

Component Blending amount (% by weight)
--------------------------------
(Diphenylmethylsiloxyphenyl methicone /
Phenylsilsesquioxane) Crosspolymer 15.0
Neosolute-MCT (Nippon Seika) 10.0
Complex of Example 3 0.2
Triethylhexanoin (Nippon Seika) Total amount of 100 Triethylhexanoic acid trimethylolpropane (Nippon Seika) 3.0
Neosolute-DE (Nippon Seika) 0.2
Neosolute-MP (Nippon Seika) 0.2
Isohexadecane 8.0
Isotridecyl isononanoate 8.0
Microcrystalline wax 8.0
Polyethylene 4.0
Candelilla Row 2.0
Carnavalo 2.0
Plandool-G (Nippon Seika) 5.0
LUSPLAN DD-DHR (Nippon Seika) 7.5
Plandool-LG2 (Nippon Seika) 6.0
Squalane 5.0
Ascorbyl tetrahexyldecanoate 0.01
Hyaluronic acid Na 0.05
Sorbitan isostearate 0.1
Tremoist-SL (Nippon Seika) 0.05
Plandool-DP (Nippon Seika) 0.01
Plandool-LG1 (Nippon Seika) 0.01
Plandool-LG3 (Nippon Seika) 0.01
Plandool-LG4 (Nippon Seika) 0.01
Plandool-S (Nippon Seika) 0.01
Tocopherol 0.1
BHT 0.01
Methylparaben 0.1
Titanium oxide Appropriate amount Zinc oxide Appropriate amount Red 202 Appropriate amount Iron oxide Appropriate amount Yellow 4 Appropriate amount Borosilicate (Ca / Al) Appropriate amount Silica Appropriate amount Tin oxide Appropriate amount --------------------- ------------
(Preparation method)
After all the components were uniformly heated and stirred, they were filled in a mold and rapidly cooled.

Example 65 Lip Balm

Component Blending amount (% by weight)
--------------------------------
Plandool-H (Nippon Seika) 10.0
Plandool-LG3 (Nippon Seika) 5.0
Polyglyceryl-2 diisostearate 15.0
Complex of Example 3 0.2
Squalane Total amount to be 100 12-hydroxystearic acid 5.0
Silylated silica 3.0
Menthol 0.5
Perfume Appropriate amount Antioxidant Appropriate amount --------------------------------
(Preparation method)
All components were heated and melted and mixed uniformly.

Example 66 Eyeshadow

Component Blending amount (% by weight)
--------------------------------
Complex of Example 3 0.2
Plandool-H (Nippon Seika) 0.6
Mica Total amount of 100 Talc 24.0
Silicone-treated titanium oxide 20.0
Silicone-treated iron oxide 1.9
Cyclomethicone 3.5
Trimethylsiloxysilicate 1.5
Octyl methoxycinnamate 1.0
Dimethicone (10cs) 0.5
Tocopherol 0.1
BHT 0.1
Phenoxyethanol 0.4
Dye Suitable amount Perfume Suitable amount --------------------------------
(Preparation method)
All ingredients were mixed uniformly.

Example 67 Foundation

Component Blending amount (% by weight)
--------------------------------
Plandool-S (Nippon Seika Co., Ltd.) 1.0
Plandool-G (Nippon Seika) 0.1
Plandool-SUN (Nippon Seika) 0.1
Plandool-MAS (Nippon Seika) 0.1
Plandool-ISS (Nippon Seika) 0.1
Complex of Example 3 0.2
Cyclomethicone 3.5
Trimethylsiloxysilicate 1.5
Talc 24.0
Iron oxide 1.9
Titanium oxide 20.0
Tocopherol 0.1
Ethylhexyl methoxycinnamate 1.0
Neosolute-AquaS (Nippon Seika) 0.4
Phenoxyethanol 0.4
Mica Total amount of 100 ----------------------------------
(Preparation method)
Stir all ingredients at high speed and mix uniformly.

Example 68 Solid powder foundation

Component Blending amount (% by weight)
--------------------------------
Part A Composite of Example 3 0.2
Plandool-MAS (Nippon Seika) 2.0
Plandool-G (Nippon Seika) 1.0
Perfluoropolyether 5.0
Part B Silicone-treated sericite 60.0
Titanium oxide 10.0
Powdered synthetic hydrocarbon wax 1.0
Yellow iron oxide 1.0
Bengala 0.5
Methylparaben 0.5
Black iron oxide 0.05
Talc Total amount of 100 --------------------------------
(Preparation method)
Mix part A warm. Take part B in a separate container and mix and disperse (part B). Add part A to part B and mix evenly.

Example 69 Solid Powder Foundation

Component Blending amount (% by weight)
--------------------------------
Part A Plandool-H (Nippon Seika) 2.0
YOFCO MAC (Nippon Seika) 0.1
Plandool-LG1 (Nippon Seika) 0.1
Plandool-LG2 (Nippon Seika) 0.1
Plandool-LG4 (Nippon Seika) 0.1
LUSPLAN PI-DA (Nippon Seika) 3.0
Cetyl ethylhexanoate (Nippon Seika) 3.0
Complex of Example 3 0.2
Squalane 1.6
Part B lecithin-treated sericite 20.0
Boron nitride 10.0
Mica 3.0
Silica 2.0
Dimethicone 3.0
Nylon-12 3.0
Talc 10.0
Titanium oxide 10.0
Iron oxide Total amount to be 100 --------------------------------
(Preparation method)
Mix part A warm. Take part B in a separate container and mix and disperse. Add part A to part B and mix evenly.

Example 70 Liquid Foundation

Component Blending amount (% by weight)
--------------------------------
Part A Composite of Example 3 0.2
Octyl rearzone 1.5
Ethylhexyl methoxycinnamate 1.0
Quaternium-18 hectorite 0.5
Part B Cyclomethicone 25.0
Polyether-modified silicone mixture 5.0
(BY22-008M manufactured by Toray Dow Corning Silicone)
Polyglyceryl-2 isostearate 1.0
Titanium oxide / iron oxide mixture 12.5
Mica 6.0
Part C Glycerin 5.0
Neosolute-AquaS (Nippon Seika) 0.4
Methylparaben 0.2
Purified water Total amount of 100 --------------------------------
(Preparation method)
Part A was heated and dissolved, and part B was heated and uniformly dispersed in part A (part D). Part C is heated and dissolved, part C is added to part D with stirring, emulsified, and then cooled to about 40 ° C.

Example 71 Foundation

Component Blending amount (% by weight)
-----------------------------------
Part A Complex of Example 3 2.2
Isododecane 10.0
Neosolute-MCT (Nippon Seika) 4.0
Ethyl hexyl methoxycinnamate 3.0
Plandool-SUN (Nippon Seika) 1.0
Plandool-LG2 (Nippon Seika) 1.0
Plandool-LG4 (Nippon Seika) 1.0
Vaseline 1.0
Isotridecyl isononanoate 2.0
Ascorbyl tetrahexyldecanoate 0.1
Dextrin palmitate 0.3
Sorbitan isostearate 1.5
Tribehenine 0.5
(Butyl acrylate / dimethacrylate glycol) cross polymer,
Silica, (Methyl methacrylate / Dimethacrylate glycol)
Cross-polymer mixture 2.0
Boron nitride 1.0
Polysorbate 20 2.0
PEG-60 hydrogenated castor oil 1.0
Distemalimonium Hectorite (20%) 2.5
Polypropylsilsesquioxane Cyclopentasiloxane mixture 1.0
Mica 15.0
Talc 4.0
Zinc oxide 5.0
Titanium oxide 10.0
Iron oxide 1.5
Part B Water Total amount of 100 DPG 4.0
Maltitol (75% solution) 1.0
Neosolute-AquaS (Nippon Seika) 0.4
Na chloride 1.0
BG 1.0
Tremoist-SL (Nippon Seika) 1.0
Ethanol 0.5
Phenoxyethanol 0.3
-----------------------------------
(Preparation method)
Part A was heated to about 70 ° C., stirred well, and uniformly dispersed. Part B was heated to about 70 ° C. and homogenized, then part B was added to part A, stirred and emulsified at about 70 ° C., and cooled to about 40 ° C.

Example 72 Sunscreen cosmetics

Component Blending amount (% by weight)
----------------------------------
Part A Ultrafine Titanium Oxide 5.0
Amount of purified water totaling 100 BG 7.0
Edetate disodium 0.05
Triethanolamine 1.0
Part B Oxybenzone 3.0
Octyl paramethoxycinnamate5.0
t-Butylmethoxybenzoylmethane 3.0
Complex of Example 3 0.2
Diethylhexyl sebacate (Nippon Seika) 8.0
Plandool-H (Nippon Seika) 2.0
Plandool-SUN (Nippon Seika) 2.0
Plandool-MAS (Nippon Seika) 0.1
Plandool-LG1 (Nippon Seika) 0.1
Plandool-LG2 (Nippon Seika) 0.1
Plandool-LG3 (Nippon Seika) 0.1
Plandool-LG4 (Nippon Seika) 0.1
LUSPLAN PI-DA (Nippon Seika) 3.0
Cetyl ethylhexanoate (Nippon Seika) 3.0
Diisopropyl sebacate (Nippon Seika) 5.0
Stearyl alcohol 3.0
Batyl alcohol 1.0
Stearic acid 3.0
Glyceryl monostearate 3.0
Polyethyl acrylate 1.0
Antioxidant, antiseptic, perfume Appropriate amount ----------------------------
(Preparation method)
A part A is heated and dissolved and sufficiently dispersed. A solution obtained by dissolving part B by heating was added thereto, emulsified and dispersed using a homogenizer, and stirred and cooled to room temperature.

Example 73 Sunscreen cosmetics

Component Blending amount (% by weight)
----------------------------------
Part A Composite of Example 5 0.2
Phytocompo-PP (Nippon Seika) 1.0
BG 10.0
Glycerin 9.0
Part B Octocrylene 4.0
Octyl salicylate 4.0
Diethylaminohydroxybenzoyl hexyl benzoate 2.25
t-Butylmethoxydibenzoylmethane 1.0
Diethylhexyl sebacate (Nippon Seika) 3.0
Pentaerythrityl tetraethylhexanoate (Nippon Seika) 2.0
Diisopropyl sebacate (Nippon Seika) 1.0
Behenyl alcohol 2.0
Cetearyl alcohol 2.0
Plandool-MAS (Nippon Seika) 1.0
Tocopherol 0.05
Part C Neosolue-AquaS (Nippon Seika) 1.0
Methylparaben Appropriate amount Water Total amount of 100 parts D Carbomer (2%) 5.0
Tremoist-SL (Nippon Seika) 10.0
Water-dispersed titanium oxide 5.0
----------------------------------
(Preparation method)
Disperse part A uniformly. Part B and part C are each heated to about 70 ° C. and dissolved. After part B is gradually added to part A, part C is gradually added and emulsified. Cool with stirring, add part D at 45 ° C. and stir.

Example 74 Antiperspirant

Component Blending amount (% by weight)
----------------------------------
Alum 5.0
Zinc oxide (zinc flower) 1.0
Silica 8.0
(Dimethicone / Vinyl Dimethicone) Cross Polymer 3.0
Paraffin 10.0
Stearyl alcohol 10.0
Complex of Example 3 0.5
Cyclomethicone Total amount of 100 Methylphenylpolysiloxane 8.0
PEG-9 Dimethicone 2.0
----------------------------------
(Preparation method)
All components were heated and melted and mixed uniformly.

Example 75 Antiperspirant

Component Blending amount (% by weight)
----------------------------------
Alum 10.0
Isopropyl methylphenol 0.1
Menthol 0.2
Diisostearyl malate (Nippon Seika) Total amount of 100 Example 3 complex 0.2
Plandool-MAS (Nippon Seika) 1.0
Plandool-H (Nippon Seika) 0.1
YOFCO MAC (Nippon Seika) 0.1
Plandool-LG1 (Nippon Seika) 0.1
Plandool-LG2 (Nippon Seika) 0.1
Plandool-LG3 (Nippon Seika) 0.1
Plandool-LG4 (Nippon Seika) 0.1
LUSPLAN PI-DA (Nippon Seika) 0.1
Cetyl ethylhexanoate (Nippon Seika) 0.1
Sorbitan sesquiisostearate 3.0
Stearyl alcohol 50.0
BHT 0.005
----------------------------------
(Preparation method)
All components were heated and melted and mixed uniformly.

Example 76 Antiperspirant

Component Blending amount (% by weight)
----------------------------------
Complex of Example 3 0.1
Baked Alum 5.0
Isopropyl methylphenol 0.1
Menthol 0.1
Tocopherol 0.03
Cellulose 1.0
Octyldodecanol 10.0
Ethylhexyl palmitate (Nippon Seika) 10.0
Triethylhexanoin (Nippon Seika) 10.0
Cetyl ethylhexanoate (Nippon Seika) 5.0
Diethylhexyl sebacate (Nippon Seika) 5.0
Tri (caprylic / capric) glyceryl (Nippon Seika) 10.0
Silica 2.0
Microcrystalline wax 3.0
Polymethylsilsesquioxane 1.0
Methyl methacrylate cross polymer 1.0
Methylphenylpolysiloxane 10.0
Distearyldimethylammonium hectorite 3.0
Dextrin palmitate 1.0
Trilaureth-4-phosphate 1.0
Ethanol 5.0
Diisostearyl malate (Nippon Seika) Total amount of 100 --------------------------------- −
(Preparation method)
All components were heated and melted and mixed uniformly.

Example 77 Cosmetic Oil

Component Blending amount (% by weight)
---------------------------------
Part A Diisostearyl malate (Nippon Seika) Total amount of 100 Complex of Example 5 1.0
Octyldodecanol 40.0
Plandool-LG2 (Nippon Seika) 3.0
Ceramide 2 1.0
Ceramide 5 1.0
Cholesterol 5.0
Preservative Appropriate amount ----------------------------------
(Preparation method)
All components were stirred and mixed at about 90 ° C. and then allowed to cool.

Example 78 Tint Gloss

Component Blending amount (% by weight)
---------------------------------
Part A Diethylhexyl succinate (Nippon Seika) Total amount of 100 Example 3 complex 1.0
Red 218 0.04
Red 223 0.02
Preservative appropriate amount Antioxidant appropriate amount Part B Dimethylsilylated silica 6.0
Pentaerythrityl tetraisostearate5.0
Part C Hydrogenated polyisobutene 15.0
LUSPLAN DD-DA5 (Nippon Seika) 5.0
LUSPLAN DD-DA7 (Nippon Seika) 10.0
---------------------------------
(Preparation method)
After A part is heated and stirred and mixed uniformly, B part is mixed with A part which has been returned to room temperature, stirred and dispersed, and C part is added and mixed.

In the above formulation, details of the components described by the product name are as follows.
* Plandool-H: Dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
* Plandool-S: Dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
* Plandool-G: Dimer dilinoleic acid dimer dilinoleyl bis (behenyl / isostearyl / phytosteryl)
O Plandool-DP: Bisdiglyceryl polyacyl adipate-2
O Plandool-ISS: Phytosteryl isostearate O Plandool-SUN: Sunflower seed oil fatty acid phytosteryl O Plandool-MAS: Macadamia nut oil fatty acid phytosteryl O Plandol-LG1: Lauroyl glutamate di (phytosteryl / octyldodecyl / behenyl)
○ Plandool-LG2: dilauroyl glutamate (phytosteryl / octyldodecyl)
○ Plandool-LG3: dilauroyl glutamate (phytosteryl / octyldodecyl / behenyl)
O Plandool-LG4: dilauroyl glutamate (phytosteryl / octyldodecyl / behenyl)
O LUSPLAN DD-IS: Dimerostearic acid dimer dilinoleyl O LUSPLAN PI-DA: Dimer dilinoleic acid di (isostearyl / phytosteryl)
O LUSPLAN DD-DHR: Dimer dilinoleic hydrogenated rosin condensate O LUSPLAN DD-DA5: Dimer dilinoleic acid dimer dilinole O LUSPLAN DD-DA7: Dimer dilinoleic acid dimer dilinole O LUSPLAN SR-DM4: Dai Merlinoleic acid dimerlinoleyl, tri (caprylic acid / capric acid) glyceryl o LUSPLAN SR-DP4: dimer linoleic acid dimer linoleyl, tetraisostearate pentaerythrityl Neosolue-Aqulio: bisethoxydiglycol cyclohexanedicarboxylate ○ Neosolue-Aqua: (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, glycerin ○ Neosolue-AquaS: (eicosane diacid / Tradecanedioic acid) polyglyceryl-10, glycerin o Neosole-MP: dineopentanoic acid methylpentanediol o Neosole-DE: dineopentanoic acid diethylpentanediol o Neosole-MCT: tri (caprylic acid / capric acid) glyceryl o phytocompo-PP: hydrogenated Lecithin, phytosterols ○ Phytocompo-C: hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6II
〇Phytocompo-SP: hydrogenated lecithin, phytosterols, BG, glycerin 〇Phytosome MEL: glycolipid, hydrogenated lecithin, BG, purified water 〇ercalactone MCT: γ-docosalactone, tri (caprylic acid / capric acid) glyceryl 〇 Elcalactone DES: γ-docosalactone, diethyl sebacate ○ Tremoist-TP: white jellyfish polysaccharide ○ Tremoist-SL: white jellyfish polysaccharide aqueous solution (1%)
* YOFCO MAC: Macadamia nut oil fatty acid cholesteryl * LP70H: Hydrogenated lysolecithin * Belpol DC-30: Dihydrocholes-30

Claims (8)

The following components (A) and (B);
(A) Phospholipid composition comprising the following components (A1) and (A2) (A1) Phosphatidylinositol (A2) Lecithin (B) Removal of organic solvent from solution in which sterols are uniformly dissolved in organic solvent And the composite used for preparation of the emulsification or solubilization composition obtained by depositing component (A) (B) simultaneously, Comprising: Content of the component (A) in a composite is 60-99. A composite comprising 1% by weight and 40% by weight of component (B). The composite of claim 1, further comprising an antioxidant as component (C), removing the organic solvent from the solution in which components (A) to (C) are uniformly dissolved in the organic solvent, A composite used for preparing an emulsified or solubilized composition obtained by simultaneously depositing (A) to (C), wherein the content of component (A) in the composite is 40 to 99.99 weight %, The content of component (B) is 1 to 40% by weight, and the content of component (C) is 0.01 to 20% by weight. The composite according to claim 1 or 2, wherein the weight ratio of the components (A1) and (A2) is 5:95 to 50:50. The complex according to any one of claims 1 to 3, wherein the phosphatidylcholine (PC) content in the lecithin of the component (A2) is 50 to 99% by weight. The complex according to any one of claims 1 to 4, wherein the lecithin as the component (A2) is a mixture of hydrogenated lecithin and unhydrogenated lecithin. Cosmetics or skin external preparation characterized by including the composite_body | complex in any one of Claims 1-5. The premix composition used for preparation of the emulsification or solubilization composition containing the composite_body | complex in any one of Claims 1-5, and a polyhydric alcohol. An emulsified or solubilized composition obtained by dispersing the premix composition according to claim 7 in water.