WO2018221337A1 - Antimicrobial composition - Google Patents

Antimicrobial composition Download PDF

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Publication number
WO2018221337A1
WO2018221337A1 PCT/JP2018/019786 JP2018019786W WO2018221337A1 WO 2018221337 A1 WO2018221337 A1 WO 2018221337A1 JP 2018019786 W JP2018019786 W JP 2018019786W WO 2018221337 A1 WO2018221337 A1 WO 2018221337A1
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WIPO (PCT)
Prior art keywords
acid
component
group
alkyl group
antibacterial
Prior art date
Application number
PCT/JP2018/019786
Other languages
French (fr)
Japanese (ja)
Inventor
鈴木　裕之
麻貴子 八澤
津島　康宏
Original Assignee
株式会社Adeka
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Priority to JP2019522153A priority Critical patent/JP7178996B2/en
Publication of WO2018221337A1 publication Critical patent/WO2018221337A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A01N31/14—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Definitions

  • the present invention relates to an antibacterial composition that can be used in cosmetics and the like.
  • antibacterial agents are often used for antiseptic purposes.
  • Parabens are most used as antibacterial agents for cosmetics and the like, but parabens are highly irritating to the skin, and their use concentration in cosmetics is limited to 1% by mass or less.
  • an increasing number of people have an allergic reaction to parabens, and the demand for cosmetics not containing parabens has increased.
  • high antibacterial properties can be obtained by the combined use of parabens and benzyloxyethanol (see, for example, Patent Documents 1 and 2).
  • Patent Documents 1 and 2 discusses the amount of parabens used can be reduced, allergies due to parabens are known. The reaction cannot be eliminated.
  • alkanediol compounds such as 1,2-octanediol have high antibacterial properties and are safer to the human body than parabens. Therefore, they are blended in cosmetics as antibacterial agents to replace parabens.
  • antibacterial properties of alkanediol compounds may be reduced in emulsified cosmetics.
  • it has high antibacterial property against bacteria, it has insufficient antibacterial property against fungi such as mold. For this reason, development of an antibacterial agent that exhibits high antibacterial properties even in an emulsifying system, is effective not only for bacteria but also for fungi, and can be blended in cosmetics and the like is required.
  • the present inventors have intensively studied, and found that the alkanediol compound has a synergistic effect of benzyloxyethanol and antibacterial properties, leading to the present invention. That is, the present invention is an antibacterial composition containing a diol compound represented by the following general formula (1) as the component (A) and benzyloxyethanol as the component (B).
  • R 1 represents an alkyl group having 3 to 8 carbon atoms.
  • the effect of the present invention is to provide an antibacterial composition exhibiting high antibacterial properties even in an emulsifying system and having high antibacterial properties against fungi such as molds.
  • R 1 represents an alkyl group having 3 to 8 carbon atoms.
  • alkyl group having 3 to 8 carbon atoms include propyl group, isopropyl group, butyl group, isobutyl group, secondary butyl group, t-butyl group, pentyl group, isopentyl group, secondary pentyl group, t-pentyl group, and hexyl.
  • R 1 is preferably a propyl group, a butyl group, a pentyl group, a hexyl group or a heptyl group, more preferably a pentyl group or a hexyl group, and most preferably a hexyl group because of its high antibacterial properties.
  • diol compound represented by the general formula (1) examples include 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1, 2-nonanediol and the like.
  • the component (B) of the present invention is benzyloxyethanol.
  • the ratio of the component (A) to the component (B) is not particularly limited, but the ratio of the component (A) to the component (B) is preferably 10:90 to 90:10 by mass, : 80 to 80:20 is more preferable, and 30:70 to 70:30 is most preferable.
  • the mass ratio of the (A) component to the (B) component is extremely large, the antibacterial improvement effect of the (A) component by the (B) component may be reduced, and the mass ratio is extremely small. In some cases, the antibacterial properties of the component (A) may decrease.
  • the amount of the antibacterial composition of the present invention varies depending on the application used, and is not particularly limited. However, if the amount is too small, the antibacterial effect may be low.
  • the total amount of the component (A) and the component (B) is preferably 0.001 to 10% by mass, more preferably 0.01 to 3% by mass, based on the total amount of the product to be blended. 0.1 to 2% by mass is most preferable.
  • the chelating agent, low molecular polyol (excluding the diol compound corresponding to the component (A)), nitrogen-containing nonionic surface activity is further added as the component (C). It is preferable to contain one or more compounds selected from the group consisting of an agent, a nitrogen-containing amphoteric surfactant, a plant-derived extract, and a zinc compound.
  • chelating agents include aminopolycarboxylic acid chelating agents, aromatic or aliphatic carboxylic acid chelating agents, amino acid chelating agents, ether polycarboxylic acid chelating agents, phosphonic acid chelating agents, phosphoric acid chelating agents, Examples include hydroxycarboxylic acid chelating agents, polymer electrolyte (including oligomer electrolyte) chelating agents, dimethylglyoxime, ascorbic acid, thioglycolic acid, phytic acid, glyoxylic acid, and glyoxalic acid. These chelating agents may be in the free acid form or in the form of a salt such as sodium salt, potassium salt, or ammonium salt. Furthermore, they may be in the form of their ester derivatives which are hydrolysable.
  • aminopolycarboxylic acid chelating agent examples include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, N- (2 -Hydroxyethyl) ethylenediaminetriacetic acid, glycol etherdiaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid and their salts.
  • aromatic or aliphatic carboxylic acid chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvic acid, salicylic acid, Examples include acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranilic acid), phthalic acid, fumaric acid, trimellitic acid, gallic acid, hexahydrophthalic acid and salts thereof, methyl esters, and ethyl esters.
  • amino acid chelating agent examples include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts and derivatives thereof.
  • hydroxycarboxylic acid chelating agent examples include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartaric acid, lactic acid, and salts thereof.
  • Examples of the phosphonic acid-based chelating agent include iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof.
  • Examples of the phosphoric acid chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, and polyphosphoric acid.
  • polymer electrolyte (including oligomer electrolyte) chelating agent examples include acrylic acid polymer, maleic anhydride polymer, ⁇ -hydroxyacrylic acid polymer, itaconic acid polymer, and two constituent monomers of these polymers.
  • the copolymer which consists of the above and an epoxy succinic acid polymer are mentioned.
  • the compounding amount of the chelating agent is not particularly limited. However, if the amount of the chelating agent is too small, the antibacterial improvement effect may not be obtained. If the amount is too large, the antibacterial improvement corresponding to the amount added cannot be obtained.
  • the amount is preferably 0.5 to 500 parts by weight, more preferably 1 to 200 parts by weight, still more preferably 2 to 100 parts by weight, and particularly preferably 10 to 75 parts by weight with respect to 100 parts by weight of the component.
  • Examples of the low molecular polyol include, for example, ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3 -Propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, 2-methyl-1,2-propanediol, 2-methyl-1,3 -Propanediol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2-methyl-1,2-butanediol, 2-methyl-2,3-butanediol, 2-methyl-1, -Butanediol, 1,3 -Propanediol, 1,
  • Pentahydric alcohols such as adonitol, arabitol, xylitol, triglycerin; Hexavalent alcohols such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, dulcitol, talose, allose;
  • N-substituted diethanolamines such as N-methyldiethanolamine, N-ethyldiethanolamine, N-propyldiethanolamine, N-isopropyldiethanolamine, N-butyldiethanolamine, N-cyclohexyldiethanolamine, N- (2-ethylhexyl) diethanolamine;
  • the blending amount of the low molecular polyol is not particularly limited, but if the amount of the low molecular polyol is too small, the antibacterial improvement effect may not be obtained, and if the amount is too large, the antibacterial improvement corresponding to the added amount cannot be obtained.
  • the blending amount of the low molecular polyol is preferably 0.5 to 500 parts by weight, more preferably 1 to 200 parts by weight, still more preferably 2 to 100 parts by weight, based on 100 parts by weight of the component (A). 75 parts by mass is particularly preferred.
  • nitrogen-containing nonionic surfactant examples include compounds represented by the following general formulas (2) to (8).
  • R 2 represents an alkyl group or an alkenyl group
  • R 3 represents an alkyl group, an alkenyl group or a group represented by — (CH 2 CH 2 O) b —H, and a and b are each from 1 to 20
  • R 4 represents an alkyl group or an alkenyl group
  • c, d and e represent the number of each 1 ⁇ 20, f represents a number of 2-3.
  • R 5 represents an alkyl group or an alkenyl group.
  • R 6 represents an alkyl group or an alkenyl group
  • R 7 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group represented by — (R 9 O) h —H
  • R 8 and R 9 represents an alkylene group having 2 to 3 carbon atoms
  • g and h each independently represents a number of 1 to 20
  • R 10 and R 11 represent an ethylene group or a propylene group, and j and k each represent an independent number of 1 to 200, provided that R 10 and R 11 are not the same group.
  • R 12 represents an alkyl group or an alkenyl group.
  • R 13 represents an alkyl group or an alkenyl group, and m represents a number of 2 or 3.
  • R 2 represents an alkyl group or an alkenyl group
  • R 3 represents an alkyl group, an alkenyl group or a group represented by — (CH 2 CH 2 O) b —H
  • a and b are respectively Represents a number from 1 to 20.
  • R 2 is preferably an alkyl group or alkenyl group having 8 to 22 carbon atoms, and more preferably an alkyl group or alkenyl group having 12 to 18 carbon atoms.
  • R 3 is preferably a group represented by — (CH 2 CH 2 O) b —H.
  • the total value of a and b is preferably a number of 2 to 10, more preferably a number of 2 to 4.
  • R 4 represents an alkyl group or an alkenyl group
  • c, d and e represent the number of each 1 ⁇ 20
  • f represents a number of 2-3.
  • R 4 is preferably an alkyl group or alkenyl group having 8 to 22 carbon atoms, and more preferably an alkyl group or alkenyl group having 12 to 18 carbon atoms.
  • the total value of c, d and e is preferably a number of 3 to 10, more preferably a number of 3 to 5.
  • f is preferably a number of 2 to 3, more preferably a number of 3.
  • R 5 represents an alkyl group or an alkenyl group.
  • R 5 is preferably an alkyl group or alkenyl group having 8 to 22 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 18 carbon atoms, and further preferably an alkyl group or alkenyl group having 10 to 14 carbon atoms.
  • R 6 represents an alkyl group or an alkenyl group
  • R 7 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group represented by — (R 9 O) h —H
  • 8 and R 9 each represent an alkylene group having 2 to 3 carbon atoms
  • g and h each independently represents a number from 1 to 20.
  • R 6 is preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 17 carbon atoms, and still more preferably an alkyl group having 11 to 13 carbon atoms.
  • R 7 is preferably a hydrogen atom, a methyl group or —CH 2 CH 2 OH, more preferably a hydrogen atom or a methyl group.
  • R 7 is a hydrogen atom
  • g is preferably a number from 1 to 3, more preferably R 8 is an ethylene group and g is 1.
  • R 7 is a methyl group
  • R 8 is preferably an ethylene group, more preferably R 8 is an ethylene group and g is 1.
  • R 7 is —CH 2 CH 2 OH
  • R 8 is preferably an ethylene group and g is 1.
  • H is preferably 1.
  • R 10 and R 11 represent an ethylene group or a propylene group, and j and k are not 0, and each represents an independent number of 1 to 200.
  • R 10 is preferably a propylene group and R 11 is preferably an ethylene group.
  • J is preferably a number from 7 to 25, more preferably a number from 10 to 15, and still more preferably a number from 11 to 13.
  • the value of j is preferably 10 to 200%, more preferably 20 to 150%, and still more preferably 50 to 100% with respect to the value of k.
  • R 12 represents an alkyl group or an alkenyl group.
  • R 12 is preferably an alkyl group or alkenyl group having 9 to 18 carbon atoms, more preferably an alkyl group having 10 to 16 carbon atoms, and further preferably an alkyl group having 10 to 14 carbon atoms.
  • R 13 represents an alkyl group or an alkenyl group
  • m represents a number of 2 or 3.
  • R 13 is preferably an alkyl group or alkenyl group having 8 to 17 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, more preferably an alkyl group having a carbon number of 9-13. Further, m is preferably a number of 3.
  • nitrogen-containing nonionic surfactants compounds represented by the general formulas (2), (4), (5) and (7) are preferable, and the general formulas (2), (5) and (7) Is more preferable, and general formula (5) is most preferable.
  • the blending amount of the nitrogen-containing nonionic surfactant is not particularly limited, but if the nitrogen-containing nonionic surfactant is too small, the antibacterial improvement effect may not be obtained, and if it is too large, the effect of increasing the amount to match the blending amount is obtained. Therefore, the blending amount of the nitrogen-containing nonionic surfactant is preferably 0.5 to 500 parts by weight, more preferably 1 to 200 parts by weight, and more preferably 2 to 100 parts by weight with respect to 100 parts by weight of the component (A). Even more preferred is 10 to 75 parts by weight.
  • nitrogen-containing amphoteric surfactant examples include compounds represented by the following general formulas (9) to (14):
  • R 14 represents an alkyl group, and n represents a number of 1 to 3)
  • R 15 represents an alkyl group or an alkenyl group, and p represents a number of 2 to 3)
  • R 16 represents an alkyl group or an alkenyl group, and q represents a number of 2 to 3)
  • R 17 represents an alkyl group or an alkenyl group.
  • R 18 represents an alkyl group or an alkenyl group, and r represents a number of 2 to 3)
  • R 19 represents an alkyl group or an alkenyl group, and s represents a number of 2 to 3)
  • R 14 represents an alkyl group, and n represents a number of 1 to 3.
  • R 14 is preferably an alkyl group having 9 to 18 carbon atoms, more preferably an alkyl group having 10 to 16 carbon atoms, and further preferably an alkyl group having 10 to 14 carbon atoms.
  • the value of n is preferably 1.
  • R 15 represents an alkyl or alkenyl group
  • p is a number from 2-3.
  • R 15 is preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and still more preferably an alkyl group having 9 to 13 carbon atoms. Further, p is preferably a number of 3.
  • R 16 represents an alkyl group or an alkenyl group
  • q represents a number of 2 to 3.
  • R 16 is preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and still more preferably an alkyl group having 9 to 13 carbon atoms. Further, q is preferably a number of 3.
  • R 17 represents an alkyl group or an alkenyl group, preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and a carbon number of 9 More preferred is an alkyl group of ⁇ 13.
  • R 18 represents an alkyl group or an alkenyl group, and r represents a number of 2 to 3.
  • R 18 is preferably an alkyl group or alkenyl group having 8 to 18 carbon atoms, more preferably an alkyl group or alkenyl group having 10 to 16 carbon atoms, more preferably an alkyl group having 10 to 14 carbon atoms.
  • R is preferably a number of 3.
  • R 19 represents an alkyl group or an alkenyl group, and s represents a number of 2 to 3.
  • R 19 is preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and further preferably an alkyl group having 9 to 13 carbon atoms. Further, s is preferably a number of 3.
  • nitrogen-containing amphoteric surfactants compounds represented by general formulas (9), (10), and (11) are preferable, general formulas (10) and (11) are more preferable, and general formula (10 ) Is most preferred.
  • the compounding amount of the nitrogen-containing amphoteric surfactant is not particularly limited, but if the amount of the nitrogen-containing amphoteric surfactant is too small, the antibacterial effect may not be obtained. Therefore, the blending amount of the nitrogen-containing amphoteric surfactant is preferably 0.5 to 500 parts by weight, more preferably 1 to 200 parts by weight, and more preferably 2 to 100 parts by weight with respect to 100 parts by weight of the component (A). Even more preferred is 10 to 75 parts by weight.
  • the plant-derived extract refers to the whole plant or algae or fungi, or specific parts such as flowers, leaves, stems, fruits, bark, roots, seeds, resins, etc., as they are, or pressed, dried, ground or fermented. Is obtained by extraction with a solvent at room temperature or under heating, and is soluble in water, ethanol, propylene glycol or oils and fats. Alternatively, the extract may be diluted, concentrated or dried. Further, it may be an essential oil obtained by using a steam distillation method, an extraction method, a chromatography method or the like.
  • an extraction solvent those usually used for extraction of natural product components, such as water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as ethylene glycol, propylene glycol, butylene glycol and glycerin; acetone and methyl ethyl ketone Ketones such as methyl acetate and ethyl acetate; ethers such as tetrahydrofuran, diethyl ether and polyethylene glycol; halogenated hydrocarbons such as dichloroethane and chloroform; aliphatics such as petroleum ether, n-hexane and cyclohexane Hydrocarbons; aromatic hydrocarbons such as toluene; pyridines; sodium chloride solution, and the like. Water, ethanol, propylene glycol, and butylene glycol are particularly preferable.
  • Plants that can be used as plant-derived extracts include, for example, arch chalk, almond, eye, Aisenhard thia polystacia, eyebright, blue-green agave, aomoji, acacia concina, acacia senegal, acacia senegal gum, acacia decreens, red clover, Akaharunire, Akayamajiou, Agi, Agrimonia eupatoria, Akebobi, Asagaokakaraksa, thistle, reed, ashitaba, ajugatsu kestanika, azuki, asunaro, asparagus, asparagus sine alice, acerola, asenayaku, asenayakashi, atlas Gaith Suleio Calpus, Avenas Trigosa, Avocado, Ama, Amacha, Amacharu, Amadokoro, Amamo, Amiris Balsamifera, American Pikachi, Ameri Salamander, American Sho
  • Trolley Prunus, Nagii Kada, Eggplant, Natsuna, Natsume, Natsujirigi, Natsubodaiju, Jujube, Date Palm, Nanyou, Nambanai, Nanbanksafuji, Nioisumire, Niotenjii Carrot, garlic, nymphea alba, pear arabic, white rose, lawnen hallen, burdock violet, wild rose, noborgiku, pineapple, hibiscus, pine, baobab, bakuchia citriodora, bacmondow, bacopamonniera, hagoromogusa, crayfish, parsley Sugenisteroides, PassifloraSync, pearl barley, banana, hana hakka, honeysuckle, vanilla, vanilla tahi Nasis, Hanesenna, Papaya, Paphiopedilum Maudiae, Haberlea Rhodopensis, Hermanus, Hamamelis, Hayatouri
  • Plantagopsisium Primula shikimensis, prunes, prunus africana, prunus serochina, plumeria, plectrants barbatas, brethia hyacinthina, bay, hayflower, hazelnuts, pecans, vetiver, loofah, penny royal mint, samurai, safflower , Safflower assembly, peppo pumpkin, hera plantain, pelargonium capitotum, helicris arenaarium, helichry angstiholium, helichry italikum, bergamot, pertoforma dasilachis, peruvian balsam, bergamot, berberis aqua horiophysi Naris, Henna, Hen Ruda, Butterflies, Boushokuboku, Bowshunka, Binsengka, Buttercup, Spinach, Hawkweed, Honoki, Hokubeif Rhododendron, Bocoa pro
  • Melissa (aka Kousuihakka), Melilot, Melosria, Melon, Mentaalbensis, Moukomugi, Mourera fulviachiris, Mokuren, Moscatara rose, Mosbean, Motsuyakuju, Peach, Momotana, Yakumoso, Yagurabiku, Yashayanagiya, Nagiyanaya, Nachiyanaya Yamazakura, Yamanomu, Yamabugu, Yugao, Eucalyptus, Yupatrium Ayapana, Yupatrium Rebaudiumum Bertoni, Yukinoshita, Yuzu, Yuzoboku, Yucha, Yucca Grauca, Yukka Shijigera, Yuri, Yuzutsurukinbai, Yoshokuzuki, Yuzu Pokeweed, European goldenrod, European raspberry, European chestnut, European black porcupine, European birch, European beech, European Mannengusa, European fir, Artemisia, Artemisia, Lychee (
  • Asco Film Nodosum Aname, Oukimo, Okinawa Mozuku, Gigalchinasterata, Kujermaniela Girata, Sargassum Filipendula, Sargassum Fusifom, Sargassum Muticam, Sfaceraria scoparia, Durvillea Antarcica, Padina Pavonica Himantalia Elongata, Fucus Serats, Pervetian Canarikurata, Macrocystis pirifera, Mitsushi Kombu, Laminaria Ochroika, Laminaria Croustoni, Laminaria Diguitta, Laminaria Hiperborea, Wakame, Asparagopsis Armata, Igis, Kaguibaranori , Catamen giraffe rhinoceros, geridium curchira guineum, saimi, striped primrose, duls, chinolimo, tochaka, porphyridium cruentum, marbaticima macrono , Lysosamnium coralioides,
  • lichens and mycelium such as Ebernia furfracea, Tsunotake moss, Usnia barbata, Oshagujitake, Hippopotamus, Shiitake, Ningyotake, Himematsutake, Fuyushinatsutake, bamboo shoot, Cordillus edulis and Cordyceps.
  • the blending amount of the plant-derived extract is not particularly limited, but if the plant-derived extract is too small, the antibacterial improvement effect may not be obtained, and if it is too large, the increase effect corresponding to the blending amount cannot be obtained.
  • the blending amount of the extract is preferably 0.1 to 1000 parts by mass, more preferably 0.5 to 200 parts by mass, and most preferably 1 to 100 parts by mass with respect to 100 parts by mass of the component (A).
  • Examples of the zinc compound include zinc acetate, zinc laurate, zinc myristate, zinc palmitate, zinc ricinoleate, zinc undecylenate, zinc aspartate, zinc acetylmethionine, zinc gluconate, zinc citrate, polypyrrolidone carboxylic acid Organic acid zinc salts such as zinc and zinc picolinate; Zinc sulfonates such as zinc p-phenolsulfonate; Zinc phosphate zinc salts such as zinc ascorbyl phosphate, sodium cetyl phosphate and DNA zinc; Zinc complexes such as zinc pyrithione Zinc supported zeolite such as (silver / zinc / ammonium) zeolite and silicic acid (ammonium / silver / zinc / aluminum); aluminum hydroxide such as aluminum oxide / zinc, aluminum oxide / zinc / cerium, aluminum oxide / zinc / iron Baked product such as sulfuric acid Inorganic zinc salts such as lead, zinc sulf
  • the solubility in 100 g of water at 20 ° C. is preferably 5 g or more, and the solubility is more preferably 10 g or more.
  • zinc compounds include zinc sulfate, zinc chloride, zinc gluconate, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, potassium zinc sulfate, and zinc iodide.
  • the compounding amount of the zinc compound is not particularly limited. However, if the amount of the zinc compound is too small, the antibacterial effect may not be obtained. If the amount is too large, the effect of increasing the amount according to the compounding amount cannot be obtained.
  • the amount is preferably 0.02 to 10 parts by mass, more preferably 0.05 to 5 parts by mass, and most preferably 0.1 to 2 parts by mass with respect to 100 parts by mass of the component (A).
  • the antibacterial composition of the present invention has a chelating agent, a low molecular polyol (however, ( A) except diol compounds corresponding to the component), and preferably one or two or more compounds selected from the group consisting of nitrogen-containing nonionic surfactants, chelating agents and nitrogen-containing nonionic surfactants More preferably, it contains one or more compounds selected from the group consisting of:
  • the antibacterial composition of the present invention can exhibit a high antibacterial effect not only in a uniform aqueous solution but also in an emulsifying system, and in the case of an emulsifying system, an O / W emulsion or a W / O emulsion may be used. W / O / W emulsions and these types may also be used.
  • the antibacterial composition of the present invention has a high antibacterial effect not only on bacteria but also on fungi such as molds.
  • the use of the antibacterial composition of the present invention is not particularly limited, and can be used in the same manner as known antibacterial agents, disinfectants, disinfectants, and antifungal agents for the purpose of antibacterial, sterilization, disinfection, antifungal and the like. it can.
  • commonly employed methods such as a method of spraying on an object to be subjected to antibacterial treatment, a method of applying, a method of impregnating the object, and a method of immersing the object can be used as they are.
  • the antibacterial composition of the present invention is a medical cleaning agent for the purpose of disinfecting and cleaning medical instruments and affected parts, a household cleaning agent for sterilizing and cleaning dishes, a food industry cleaning agent, a container transfer Impregnating lubricants for conveyors, food packaging films, fibers, synthetic resins, wood, antibacterials for antibacterial processing of daily necessities, body cleaners, cosmetics, softeners for clothing, aqueous or non-aqueous paints, non-woven fabrics, etc.
  • all fibers such as cotton, polyester, acrylic, and nylon may be treated by a general method such as stirring, dipping or spraying.
  • the antibacterial composition of the present invention can be applied or sprayed onto the surface of wood, daily necessities and the like. Furthermore, when used for synthetic resins, etc., it may be adhered to the surface by applying or spraying the antibacterial composition of the present invention after molding, or kneaded at the time of molding to maintain the antibacterial effect. You can also.
  • the antibacterial composition of the present invention is highly safe for the human body, it is preferably used for cosmetics and body cleaning agents that directly touch the human body, such as cosmetics and body wash used on the face. More preferably, it is used in the preparation.
  • cosmetics include, for example, shampoo, dry shampoo, rinse-integrated shampoo, hair rinse, hair conditioner, hair pack, hair treatment, hair tonic, pomade. , Tics, hair creams, hair waxes, hair gels, hair foams, hair mousses, hair mists, hair lotions, permanent waving agents, hair dyes, etc .; facial cleansers, facial cleansing creams, facial cleansing foams, cleansing creams, cleansing foams, hands Soap, body soap, body lotion, sunscreen agent, lotion, milky lotion, serum, face cream, cold cream, face pack, antiperspirant, shaving soap, shaving foam, shaving Skin care cosmetics such as ir, shaving lotion, after shave lotion, after sun lotion; makeup cosmetics such as foundation, concealer, face powder, blusher, mascara, eyeliner, eye shadow; lip balm, bathing agent, etc. It is done.
  • the cosmetic containing the antibacterial composition of the present invention may contain a surfactant usually used in cosmetics.
  • surfactants include anionic surfactants, cationic surfactants, nitrogen-free nonionic surfactants, and the like.
  • anionic surfactant examples include higher fatty acid salts, higher alcohol sulfate esters, sulfated olefin salts, higher alkyl sulfonates, ⁇ -olefin sulfonates, sulfated fatty acid salts, sulfonated fatty acid salts, and phosphoric acid.
  • Counter ions of such anionic surfactant salts include alkali metal ions such as lithium, sodium and potassium; alkaline earth metal ions such as calcium and magnesium; ammonium; monoethanolammonium, diethanolammonium and triethanolammonium And organic ammonium such as monoisopropanolammonium, diisopropanolammonium and triisopropanolammonium.
  • cationic surfactants include amine surfactants such as alkyldimethylamine, alkenyldimethylamine, fatty acid dimethylaminopropylamide, and fatty acid diethylaminoethylamide; alkyltrimethylammonium salts, alkenyltrimethylammonium salts, alkyldiethanolammonium salts Alkenyldiethanolammonium salt, alkyldimethylbenzylammonium salt, alkenyldimethylbenzylammonium salt, dialkyldimethylammonium salt, alkyldiethanolammonium salt, alkylpyridinium salt, 3-alkoxy-2-hydroxypropyltrimethylammonium salt, polyoxypropylenemethyldiethylammonium salt Examples thereof include ammonium salt surfactants such as salts. Examples of the counter ion of the ammonium salt surfactant include chlorine ion and bromine ion.
  • nitrogen-free nonionic surfactants include polyoxyalkylene alkyl ethers, polyoxyalkylene alkenyl ethers, polyoxyethylene polyoxypropylene alkyl ethers (addition forms of ethylene oxide and propylene oxide include random and block forms) Any), polyethylene glycol propylene oxide adduct, polypropylene glycol ethylene oxide adduct, glycerin fatty acid ester or ethylene oxide adduct thereof, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyl polyglucoside, sucrose fatty acid ester, alkyl (Poly) glycerin ether, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, fatty acid methyl Ester ethoxylates, and the like.
  • Cosmetics and cleaning agents containing the antibacterial composition of the present invention in addition to the surfactant component described above, other components, such as silicone oil, thickener, oil agent, as long as the object of the present invention is not impaired.
  • Powders pigments, dyes, resins
  • other antibacterial agents such as silicone oil, thickener, oil agent
  • fragrances such as silicone oil, thickener, oil agent
  • moisturizers such as silicone oil, thickener, oil agent
  • physiologically active ingredients such as sodium salts, sodium salts, sodium salts, solvents, antioxidants, chelating agents, pearlizing agents, neutralizing agents, pH adjusters, enzymes, etc.
  • Components can be appropriately blended.
  • the thickener examples include dimethyldiallylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer, cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar , Gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabinogalactan, caraya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, ⁇ -glucan, gellan gum And dextran.
  • oils examples include volatile and nonvolatile hydrocarbons usually used in cosmetics, higher alcohols, medium to high chain fatty acids and esters thereof, fats and oils, and may be liquid, paste, or solid at room temperature. However, a liquid excellent in handling is preferable.
  • the oil agent include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol and octyldodecanol, fatty acids such as isostearic acid, undecylenic acid and oleic acid, myristyl myristate, hexyl laurate, and oleic acid.
  • Decyl isopropyl myristate, hexyldecyl dimethyloctanoate, glyceryl monostearate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, hydrocarbons such as liquid paraffin, petrolatum, squalane, lanolin, reduction Examples include waxes such as lanolin and carnauba wax, oils and fats such as mink oil, cacao butter, coconut oil, palm kernel oil, camellia oil, sesame oil, castor oil and olive oil.
  • the powder examples include pigments such as red No. 201, yellow No. 4, blue No. 1, black No. 401, lake pigments such as yellow No. 4 Al lake, yellow No. 203 Ba lake, nylon powder, silk powder, and silicone powder. , Cellulose powder, silicone elastomer spherical powder, polymers such as polyethylene powder, yellow iron oxide, red iron oxide, chromium oxide, carbon black, colored pigments such as ultramarine and bitumen, white pigments such as zinc oxide and titanium oxide, talc Body pigments such as mica, sericite, kaolin, pearl pigments such as titanium mica, metal salts such as barium sulfate, calcium carbonate, magnesium carbonate, magnesium silicate, inorganic powders such as silica and alumina, bentonite, smectite, boron nitride Etc. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, indeterminate, flake-
  • These powders are treated with conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, Surface treatment may be performed in advance by acrylic acid treatment, metal soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, or the like.
  • antibacterial agents include, for example, paraben antibacterial agents such as methyl paraben and ethyl paraben; imidazole antibacterial agents such as thiabendazole, methyl 2-benzimidazolylcarbamate and imidazolidinyl urea; trichlorocarbanilide, cloflucarban, etc.
  • humectants include biopolymers such as diethylene glycol monoethyl ether, deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, sodium lactate, Examples include urea, sodium pyrrolidonecarboxylate, betaine, and whey.
  • biopolymers such as diethylene glycol monoethyl ether, deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, sodium lactate, Examples include urea, sodium pyrrolidonecarboxylate, betaine, and whey.
  • solvent examples include purified water, ethanol, light liquid isoparaffin, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, and next-generation chlorofluorocarbon.
  • Component C1 Glutamic acid diacetate 4Na
  • C2 Glycerin
  • C3 Palm fatty acid monoethanolamide (cocamide MEA)
  • Component D1 Phenoxyethanol
  • D2 Methyl paraben
  • D3 Glyceryl caprylate
  • antibacterial agents of Examples 1 to 10 and Comparative Examples 1 to 18 shown in Table 2 having the compositions shown in Table 1 were prepared.
  • the numbers in Tables 1 and 2 are mass%.
  • B.cep Burkholderia cepacia (bacteria)
  • P.aer Pseudomonas aeruginosa (bacteria)
  • A.bra Aspergillus brasiliensis (fungus)
  • Formula 1 and Formula 2 were adjusted with the following composition. There are two types of antibacterial agents, 0.4% by mass and 0.8% by mass, but those with a compounding amount of 0.4% by mass are tested for B.cep and P.aer and the amount is 0 8% by weight was used in the test against A.bra.
  • Formula 1 is a skin cream formula
  • Formula 2 is a conditioner formula
  • both emulsion systems are O / W emulsions.
  • ⁇ Formulation 1 Skin cream> Triethylhexanoin 20% by mass 4% by weight of sorbes tetraoleate-30 Cetearyl alcohol 0.2% by mass Glycerin 0.2% by mass (Acrylates / alkyl acrylate (C10-30)) Crosspolymer 0.1% by mass Antibacterial agent 0.4% by mass or 0.8% by mass Sodium hydroxide appropriate amount (adjusted to pH 6.0) Water balance
  • ⁇ Formulation 2 Hair conditioner> Stearyl alcohol 1.0 mass% Behentrimonium chloride 0.5% by mass Cetanol 0.5% by mass Amodimethicone 0.5% by mass Antibacterial agent 0.4% by mass or 0.8% by mass Water balance

Abstract

The problem addressed by the present invention is to provide an antimicrobial composition that exhibits high antimicrobial properties even in an emulsified system and has high antimicrobial properties even against molds. The present invention provides an antimicrobial composition containing a diol compound represented by general formula (1) as component (A) and benzyl oxyethanol as component (B) to solve the above problem. (In the formula, R1 represents a C3-8 alkyl group.)

Description

抗菌性組成物Antibacterial composition
　本発明は、化粧料等に使用可能な抗菌性組成物に関する。 The present invention relates to an antibacterial composition that can be used in cosmetics and the like.
　化粧料等には、防腐等の目的で抗菌剤（防腐剤）を使用することが多い。化粧料等の抗菌剤として最も使用されているのはパラベン類であるが、パラベン類は皮膚刺激性が高く、化粧料における使用濃度が１質量％以下に制限されている。また最近は、パラベン類に対してアレルギー反応を起こす人が増加しており、パラベン類を配合しない化粧料の需要が増加している。パラベン類とベンジルオキシエタノールとの併用により、高い抗菌性が得られること（例えば、特許文献１、２を参照）が知られているが、パラベン類の使用量を減らせるものの、パラベン類によるアレルギー反応をなくすことができるわけではない。 In cosmetics, antibacterial agents (preservatives) are often used for antiseptic purposes. Parabens are most used as antibacterial agents for cosmetics and the like, but parabens are highly irritating to the skin, and their use concentration in cosmetics is limited to 1% by mass or less. Recently, an increasing number of people have an allergic reaction to parabens, and the demand for cosmetics not containing parabens has increased. It is known that high antibacterial properties can be obtained by the combined use of parabens and benzyloxyethanol (see, for example, Patent Documents 1 and 2). However, although the amount of parabens used can be reduced, allergies due to parabens are known. The reaction cannot be eliminated.
　一方、１，２－オクタンジオール等のアルカンジオール化合物は、高い抗菌性を有し、パラベン類と比較して人体に対する安全性も高いことから、パラベン類に代わる抗菌剤として化粧料に配合されている（例えば、特許文献３、４を参照）。しかし、アルカンジオール化合物は、乳化系の化粧料では抗菌性が低下する場合がある。また、細菌に対しては高い抗菌性を有するが、カビ等の真菌類に対しては抗菌性が不十分である。
　このため、乳化系でも高い抗菌性を発揮し、細菌だけではなく真菌類に対しても有効で、化粧料等に配合可能な抗菌剤の開発が要求されている。 On the other hand, alkanediol compounds such as 1,2-octanediol have high antibacterial properties and are safer to the human body than parabens. Therefore, they are blended in cosmetics as antibacterial agents to replace parabens. (For example, refer to Patent Documents 3 and 4). However, antibacterial properties of alkanediol compounds may be reduced in emulsified cosmetics. Moreover, although it has high antibacterial property against bacteria, it has insufficient antibacterial property against fungi such as mold.
For this reason, development of an antibacterial agent that exhibits high antibacterial properties even in an emulsifying system, is effective not only for bacteria but also for fungi, and can be blended in cosmetics and the like is required.
特開２００５－２３２０５５号公報Japanese Patent Laying-Open No. 2005-232055 特開２００５－２３２０５６号公報Japanese Patent Laid-Open No. 2005-232056 特開平１１－３２２５９１号公報Japanese Patent Laid-Open No. 11-322591 特開２００１－０４８７２０号公報JP 2001-048720 A
　そこで本発明者等は鋭意検討し、アルカンジオール化合物が、ベンジルオキシエタノールと抗菌性の相乗効果があることを見出し、本発明に至った。即ち、本発明は、（Ａ）成分として下記の一般式（１）で表わされるジオール化合物、及び（Ｂ）成分としてベンジルオキシエタノールを含有する抗菌性組成物である。 Therefore, the present inventors have intensively studied, and found that the alkanediol compound has a synergistic effect of benzyloxyethanol and antibacterial properties, leading to the present invention. That is, the present invention is an antibacterial composition containing a diol compound represented by the following general formula (1) as the component (A) and benzyloxyethanol as the component (B).
Figure JPOXMLDOC01-appb-C000003
Figure JPOXMLDOC01-appb-C000003
（式中、Ｒ1は炭素数３～８のアルキル基を表わす。） (In the formula, R 1 represents an alkyl group having 3 to 8 carbon atoms.)
　本発明の効果は、乳化系でも高い抗菌性を発揮し、カビ等の真菌類に対しても高い抗菌性を有する抗菌組成物を提供したことにある。 The effect of the present invention is to provide an antibacterial composition exhibiting high antibacterial properties even in an emulsifying system and having high antibacterial properties against fungi such as molds.
　本発明の（Ａ）成分である、前記一般式（１）で表わされるジオール化合物について説明する。一般式（１）において、Ｒ1は炭素数３～８のアルキル基を表わす。炭素数３～８のアルキル基としては、プロピル基、イソプロピル基、ブチル基、イソブチル基、２級ブチル基、ｔ－ブチル基、ペンチル基、イソペンチル基、２級ペンチル基、ｔ－ペンチル基、ヘキシル基、２級ヘキシル基、ヘプチル基、２級ヘプチル基、オクチル基、２級オクチル基、２－メチルペンチル基、２－エチルヘキシル基等が挙げられる。Ｒ1としては、抗菌性が大きいことから、プロピル基、ブチル基、ペンチル基、ヘキシル基、ヘプチル基が好ましく、ペンチル基、ヘキシル基が更に好ましく、ヘキシル基が最も好ましい。一般式（１）で表わされるジオール化合物の、好ましい具体例としては、例えば、１，２－ペンタンジオール、１，２－ヘキサンジオール、１，２－ヘプタンジオール、１，２－オクタンジオール、１，２－ノナンジオール等が挙げられる。 The diol compound represented by the general formula (1), which is the component (A) of the present invention, will be described. In the general formula (1), R 1 represents an alkyl group having 3 to 8 carbon atoms. Examples of the alkyl group having 3 to 8 carbon atoms include propyl group, isopropyl group, butyl group, isobutyl group, secondary butyl group, t-butyl group, pentyl group, isopentyl group, secondary pentyl group, t-pentyl group, and hexyl. Group, secondary hexyl group, heptyl group, secondary heptyl group, octyl group, secondary octyl group, 2-methylpentyl group, 2-ethylhexyl group and the like. R 1 is preferably a propyl group, a butyl group, a pentyl group, a hexyl group or a heptyl group, more preferably a pentyl group or a hexyl group, and most preferably a hexyl group because of its high antibacterial properties. Preferable specific examples of the diol compound represented by the general formula (1) include 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1, 2-nonanediol and the like.
　本発明の（Ｂ）成分はベンジルオキシエタノールである。
　一般に、（Ｂ）成分に対する（Ａ）成分の配合の比は特に限定されないが、（Ａ）成分と（Ｂ）成分の比が質量比で１０：９０～９０：１０であることが好ましく、２０：８０～８０：２０であることが更に好ましく、３０：７０～７０：３０であることが最も好ましい。（Ｂ）成分に対する（Ａ）成分の質量比が極端に大きい場合には、（Ｂ）成分による（Ａ）成分の抗菌性の向上効果が小さくなる場合があり、また前記質量比が極端に小さい場合には、（Ａ）成分の抗菌性が低下する場合がある。 The component (B) of the present invention is benzyloxyethanol.
In general, the ratio of the component (A) to the component (B) is not particularly limited, but the ratio of the component (A) to the component (B) is preferably 10:90 to 90:10 by mass, : 80 to 80:20 is more preferable, and 30:70 to 70:30 is most preferable. When the mass ratio of the (A) component to the (B) component is extremely large, the antibacterial improvement effect of the (A) component by the (B) component may be reduced, and the mass ratio is extremely small. In some cases, the antibacterial properties of the component (A) may decrease.
　本発明の抗菌性組成物の使用量は、使用される用途によっても異なるため、特に限定されないが、あまり少ないと抗菌効果が低い場合があり、また、あまり多いと添加量に見合う増量効果が得られない場合があることから、（Ａ）成分と（Ｂ）成分の合計量が配合される製品の全量に対して０．００１～１０質量％が好ましく、０．０１～３質量％が更に好ましく、０．１～２質量％が最も好ましい。 The amount of the antibacterial composition of the present invention varies depending on the application used, and is not particularly limited. However, if the amount is too small, the antibacterial effect may be low. In some cases, the total amount of the component (A) and the component (B) is preferably 0.001 to 10% by mass, more preferably 0.01 to 3% by mass, based on the total amount of the product to be blended. 0.1 to 2% by mass is most preferable.
　本発明の抗菌性組成物は、抗菌効果が高まることから、更に（Ｃ）成分として、キレート剤、低分子ポリオール（但し、（Ａ）成分に該当するジオール化合物は除く）、窒素含有ノニオン界面活性剤、窒素含有両性界面活性剤、植物由来エキス、及び亜鉛化合物からなる群から選択される１種または２種以上の化合物を含有することが好ましい。 Since the antibacterial composition of the present invention has an increased antibacterial effect, the chelating agent, low molecular polyol (excluding the diol compound corresponding to the component (A)), nitrogen-containing nonionic surface activity is further added as the component (C). It is preferable to contain one or more compounds selected from the group consisting of an agent, a nitrogen-containing amphoteric surfactant, a plant-derived extract, and a zinc compound.
　キレート剤としては、例えば、アミノポリカルボン酸系キレート剤、芳香族又は脂肪族カルボン酸系キレート剤、アミノ酸系キレート剤、エーテルポリカルボン酸系キレート剤、ホスホン酸系キレート剤、リン酸キレート剤、ヒドロキシカルボン酸系キレート剤、高分子電解質（オリゴマー電解質を含む）系キレート剤、ジメチルグリオキシム、アスコルビン酸、チオグリコール酸、フィチン酸、グリオキシル酸、グリオキサール酸等が挙げられる。これらのキレート剤は、それぞれフリーの酸型であっても、ナトリウム塩、カリウム塩、アンモニウム塩等の塩の形であってもよい。さらに、それらは、加水分解可能なそれらのエステル誘導体の形であってもよい。 Examples of chelating agents include aminopolycarboxylic acid chelating agents, aromatic or aliphatic carboxylic acid chelating agents, amino acid chelating agents, ether polycarboxylic acid chelating agents, phosphonic acid chelating agents, phosphoric acid chelating agents, Examples include hydroxycarboxylic acid chelating agents, polymer electrolyte (including oligomer electrolyte) chelating agents, dimethylglyoxime, ascorbic acid, thioglycolic acid, phytic acid, glyoxylic acid, and glyoxalic acid. These chelating agents may be in the free acid form or in the form of a salt such as sodium salt, potassium salt, or ammonium salt. Furthermore, they may be in the form of their ester derivatives which are hydrolysable.
　アミノポリカルボン酸系キレート剤としては、例えば、エチレンジアミンテトラ酢酸、エチレンジアミンジ酢酸、シクロヘキサンジアミンテトラ酢酸、ニトリロトリ酢酸、イミノジ酢酸、Ｎ－（２－ヒドロキシエチル）イミノジ酢酸、ジエチレントリアミンペンタ酢酸、Ｎ－（２－ヒドロキシエチル）エチレンジアミントリ酢酸、グリコールエーテルジアミンテトラ酢酸、グルタミン酸ジ酢酸、アスパラギン酸ジ酢酸及びこれらの塩類が挙げられる。 Examples of the aminopolycarboxylic acid chelating agent include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, N- (2 -Hydroxyethyl) ethylenediaminetriacetic acid, glycol etherdiaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid and their salts.
　芳香族又は脂肪族カルボン酸系キレート剤としては、例えば、シュウ酸、マロン酸、コハク酸、グルタル酸、アジピン酸、ピメリン酸、セバシン酸、アゼライン酸、イタコン酸、アコニット酸、ピルビン酸、サリチル酸、アセチルサリチル酸、ヒドロキシ安息香酸、アミノ安息香酸（アントラニル酸を含む）、フタル酸、フマル酸、トリメリット酸、没食子酸、ヘキサヒドロフタル酸及びこれらの塩類、メチルエステル類及びエチルエステル類が挙げられる。 Examples of aromatic or aliphatic carboxylic acid chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvic acid, salicylic acid, Examples include acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranilic acid), phthalic acid, fumaric acid, trimellitic acid, gallic acid, hexahydrophthalic acid and salts thereof, methyl esters, and ethyl esters.
　アミノ酸系キレート剤としては、例えば、グリシン、セリン、アラニン、リジン、シスチン、システイン、エチオニン、チロシン、メチオニン及びこれらの塩類及び誘導体が挙げられる。
　ヒドロキシカルボン酸系キレート剤としては、例えば、リンゴ酸、クエン酸、グリコール酸、グルコン酸、ヘプトン酸、酒石酸、乳酸及びこれらの塩類が挙げられる。 Examples of the amino acid chelating agent include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts and derivatives thereof.
Examples of the hydroxycarboxylic acid chelating agent include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartaric acid, lactic acid, and salts thereof.
　ホスホン酸系キレート剤としては、例えば、イミノジメチルホスホン酸、アルキルジホスホン酸、１－ヒドロキシエタン－１，１－ジホスホン酸及びこれらの塩類が挙げられる。
　リン酸系キレート剤としては、例えば、オルトリン酸、ピロリン酸、トリリン酸及びポリリン酸が挙げられる。 Examples of the phosphonic acid-based chelating agent include iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof.
Examples of the phosphoric acid chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, and polyphosphoric acid.
　高分子電解質（オリゴマー電解質を含む）系キレート剤としては、例えば、アクリル酸重合体、無水マレイン酸重合体、α－ヒドロキシアクリル酸重合体、イタコン酸重合体、これらの重合体の構成モノマー２種以上からなる共重合体及びエポキシコハク酸重合体が挙げられる。 Examples of the polymer electrolyte (including oligomer electrolyte) chelating agent include acrylic acid polymer, maleic anhydride polymer, α-hydroxyacrylic acid polymer, itaconic acid polymer, and two constituent monomers of these polymers. The copolymer which consists of the above and an epoxy succinic acid polymer are mentioned.
　これらのキレート剤の中でも、エチレンジアミンテトラ酢酸、エチレンジアミンジ酢酸、ニトリロトリ酢酸、イミノジ酢酸、Ｎ－（２－ヒドロキシエチル）イミノジ酢酸、グルタミン酸ジ酢酸、アスパラギン酸ジ酢酸、コハク酸、サリチル酸、シュウ酸、乳酸、フマル酸、クエン酸、酒石酸、１－ヒドロキシエタン－１，１－ジホスホン酸及びこれらの塩が好ましく、エチレンジアミンテトラ酢酸、ニトリロトリ酢酸、イミノジ酢酸、Ｎ－（２－ヒドロキシエチル）イミノジ酢酸、グルタミン酸ジ酢酸、アスパラギン酸ジ酢酸、コハク酸、乳酸、酒石酸及びこれらの塩がさらに好ましく、エチレンジアミンテトラ酢酸、グルタミン酸ジ酢酸、アスパラギン酸ジ酢酸及びこれらの塩が最も好ましい。 Among these chelating agents, ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid, succinic acid, salicylic acid, oxalic acid, lactic acid , Fumaric acid, citric acid, tartaric acid, 1-hydroxyethane-1,1-diphosphonic acid and salts thereof are preferable, ethylenediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, glutamic acid diacid Acetic acid, aspartic acid diacetic acid, succinic acid, lactic acid, tartaric acid and salts thereof are more preferred, and ethylenediaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid and salts thereof are most preferred.
　キレート剤の配合量は特に限定されない。しかしながら、キレート剤があまりに少ないと抗菌性の向上効果が得られない場合があり、あまりに多いと添加量にみあう抗菌性の向上がえられなくなることから、キレート剤の配合量は、（Ａ）成分１００質量部に対して０．５～５００質量部が好ましく、１～２００質量部が更に好ましく、２～１００質量部がさらにより好ましく、１０～７５質量部が特に好ましい。 The compounding amount of the chelating agent is not particularly limited. However, if the amount of the chelating agent is too small, the antibacterial improvement effect may not be obtained. If the amount is too large, the antibacterial improvement corresponding to the amount added cannot be obtained. The amount is preferably 0.5 to 500 parts by weight, more preferably 1 to 200 parts by weight, still more preferably 2 to 100 parts by weight, and particularly preferably 10 to 75 parts by weight with respect to 100 parts by weight of the component.
　低分子ポリオール（但し、（Ａ）成分に該当するジオール化合物は除く）としては、例えば、エチレングリコール、ジエチレングリコール、トリエチレングリコール、テトラエチレングリコール、プロピレングリコール、ジプロピレングリコール、トリプロピレングリコール、１，３－プロパンジオール、１，２－ブタンジオール、１，３－ブタンジオール、１，４－ブタンジオール、２，３－ブタンジオール、２－メチル－１，２－プロパンジオール、２－メチル－１，３－プロパンジオール、１，３－ペンタンジオール、１，４－ペンタンジオール、１，５－ペンタンジオール、２，３－ペンタンジオール、２，４－ペンタンジオール、２－メチル－１，２－ブタンジオール、２－メチル－２，３－ブタンジオール、２－メチル－１，４－ブタンジオール、３－メチル－１，３ブタンジオール、２－エチル－１，３－プロパンジオール、２，２－ジメチル－１，３－プロパンジオール、１，５－ヘキサンジオール、１，６－ヘキサンジオール、２，５－ヘキサンジオール、３，３－ヘキサンジオール、２－メチル－１，３－ペンタンジオール、２－メチル－１，５－ペンタンジオール、２－メチル－２，４－ペンタンジオール、３－メチル－１，５－ペンタンジオール、３－メチル－２，３－ペンタンジオール、３－メチル－２，４－ペンタンジオール、２－エチル－２－メチル－１，３－プロパンジオール、２，２－ジメチル－２，４－ブタンジオール、１，７－ヘプタンジオール、３，４－ヘプタンジオール、２－プロピル－２－メチル－１，３－プロパンジオール、２－イソプロピル－２－メチル－１，３－プロパンジオール、１，８－オクタンジオール、３，６－オクタンジオール、２－エチル－１，３－ヘキサンジオール、２－ｓｅｃ－ブチル－２－ブチル－１，３－プロパンジオール、２，２－ジメチル－１，３－ヘキサンジオール、２，５－ジメチル－２，５－ヘキサンジオール、２，２，４－トリメチル－１，３－ペンタンジオール、１，３－ノナンジオール、１，９－ノナンジオール、３，６－オクタンジオール、２－エチル－２－（２－メチル）プロピル－１，３－プロパンジオール、２，２，４－トリメチル－１，６－ヘキサンジオール、２，４，４－トリメチル－１，６－ヘキサンジオール、２－ブチル－２－エチル－１，３－プロパンジオール、２，４－ジエチル－１，５－ペンタンジオール、２－メチル－１，８－オクタンジオール、１，１０－デカンジオール、５，６－デカンジオール、３，６－ジメチル－３，６－オクタンジオール、３，７－ジメチル－１，６－オクタンジオール、３，７－ジメチル－１，７－オクタンジオール、１，２－ウンデカンジオール、１，４－ウンデカンジオール、１，１１－ウンデカンジオール、６－エチル－３－メチル－１，６－オクタンジオール、１，２－ドデカンジオール、１，１０－ドデカンジオール、１，１２－ドデカンジオール、２，４－ジエチル－１，５－オクタンジオール、２，８，８－トリメチル－２，７－ノナンジオール、１，２－テトラデカンジオール、１，１４－テトラデカンジオール、７，８－テトラデカンジオール、１，２－ペンタデカンジオール、１，２－ヘキサデカンジオール、１，１６－ヘキサデカンジオール、１，１７－ヘプタデカンジオール、１，２－オクタデカンジオール、１，１２－オクタデカンジオール、１，２－エイコサンジオール、１，２－ドコサンジオール、１，２－テトラコサンジオール等の、飽和ジオール又はその縮合物； Examples of the low molecular polyol (excluding the diol compound corresponding to the component (A)) include, for example, ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3 -Propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, 2-methyl-1,2-propanediol, 2-methyl-1,3 -Propanediol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2-methyl-1,2-butanediol, 2-methyl-2,3-butanediol, 2-methyl-1, -Butanediol, 3-methyl-1,3-butanediol, 2-ethyl-1,3-propanediol, 2,2-dimethyl-1,3-propanediol, 1,5-hexanediol, 1,6-hexane Diol, 2,5-hexanediol, 3,3-hexanediol, 2-methyl-1,3-pentanediol, 2-methyl-1,5-pentanediol, 2-methyl-2,4-pentanediol, 3 -Methyl-1,5-pentanediol, 3-methyl-2,3-pentanediol, 3-methyl-2,4-pentanediol, 2-ethyl-2-methyl-1,3-propanediol, 2,2 -Dimethyl-2,4-butanediol, 1,7-heptanediol, 3,4-heptanediol, 2-propyl-2-methyl-1,3-propanediol, 2 Isopropyl-2-methyl-1,3-propanediol, 1,8-octanediol, 3,6-octanediol, 2-ethyl-1,3-hexanediol, 2-sec-butyl-2-butyl-1, 3-propanediol, 2,2-dimethyl-1,3-hexanediol, 2,5-dimethyl-2,5-hexanediol, 2,2,4-trimethyl-1,3-pentanediol, 1,3- Nonanediol, 1,9-nonanediol, 3,6-octanediol, 2-ethyl-2- (2-methyl) propyl-1,3-propanediol, 2,2,4-trimethyl-1,6-hexane Diol, 2,4,4-trimethyl-1,6-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 2,4-diethyl-1,5-pentanedio 2-methyl-1,8-octanediol, 1,10-decanediol, 5,6-decanediol, 3,6-dimethyl-3,6-octanediol, 3,7-dimethyl-1,6 -Octanediol, 3,7-dimethyl-1,7-octanediol, 1,2-undecanediol, 1,4-undecanediol, 1,11-undecanediol, 6-ethyl-3-methyl-1,6- Octanediol, 1,2-dodecanediol, 1,10-dodecanediol, 1,12-dodecanediol, 2,4-diethyl-1,5-octanediol, 2,8,8-trimethyl-2,7-nonane Diol, 1,2-tetradecanediol, 1,14-tetradecanediol, 7,8-tetradecanediol, 1,2-pentadecanediol, 1,2- Xadecanediol, 1,16-hexadecanediol, 1,17-heptadecanediol, 1,2-octadecanediol, 1,12-octadecanediol, 1,2-eicosanediol, 1,2-docosanediol, , 2-tetracosanediol, saturated diols or condensates thereof;
　２－ブテン－１，４－ジオール、３－ブテン－１，２－ジオール、２－メチレン－１，３－プロパンジオール、２－ブチン－１，４－ジオール、５－ヘキセン－１，２－ジオール、３－メチル－２－ペンテン－１，５－ジオール、３－メチレンペンタン－１，５－ジオール、１，５－ヘキサジエン－３，４－ジオール、７－オクテン－１，２－ジオール、２，５－ジメチル－３－ヘキセン－２，５－ジオール、９－デセン－１、２－ジオール、２，６－ジメチル－７－オクテン－２，６－ジオール、３，７－ジメチル－７－オクテン－１，６－ジオール、１３－テトラデセン－１、２－ジオール、１２－ヒドロキシ－９－オクタデセノール、２－ペンチン－１，４－ジオール、３－ヘキシン－２，５－ジオール、４－メチル－２－ペンチン－１，４－ジオール、３－ヘプチン－２，５－ジオール、４－メチル－２－ペンチン－１，４－ジオール、３，４－ジメチル－１－ペンチン－３，４－ジオール、２，５－ジメチル－３－ヘキシン－２，５－ジオール、５－デシン－４，７－ジオール、２，６－ジメチル－７－オクチン－２，６－ジオール、３，６－ジメチル－４－オクチン－３，６－ジオール、２，３，６，７－テトラメチル－４－オクチン－３，６－ジオール、２，４，７，９－テトラメチル－５－デシン－４，７－ジオール、２，５，８，１１－テトラメチル－６－ドデシン－５，８－ジオール、１，１，４，４－テトライソプロピル－４－オクチン－３，６－ジオール、５，１０－ジエチル－７－テトラデシン－６，９－ジオール等の不飽和ジオール； 2-butene-1,4-diol, 3-butene-1,2-diol, 2-methylene-1,3-propanediol, 2-butyne-1,4-diol, 5-hexene-1,2-diol 3-methyl-2-pentene-1,5-diol, 3-methylenepentane-1,5-diol, 1,5-hexadiene-3,4-diol, 7-octene-1,2-diol, 2, 5-dimethyl-3-hexene-2,5-diol, 9-decene-1,2-diol, 2,6-dimethyl-7-octene-2,6-diol, 3,7-dimethyl-7-octene- 1,6-diol, 13-tetradecene-1,2-diol, 12-hydroxy-9-octadecenol, 2-pentyne-1,4-diol, 3-hexyne-2,5-diol, 4-methyl-2- Pentin 1,4-diol, 3-heptin-2,5-diol, 4-methyl-2-pentyne-1,4-diol, 3,4-dimethyl-1-pentyne-3,4-diol, 2,5- Dimethyl-3-hexyne-2,5-diol, 5-decyne-4,7-diol, 2,6-dimethyl-7-octyne-2,6-diol, 3,6-dimethyl-4-octyne-3, 6-diol, 2,3,6,7-tetramethyl-4-octyne-3,6-diol, 2,4,7,9-tetramethyl-5-decyne-4,7-diol, 2,5, 8,11-tetramethyl-6-dodecin-5,8-diol, 1,1,4,4-tetraisopropyl-4-octyne-3,6-diol, 5,10-diethyl-7-tetradecine-6 Unsaturated diols such as 9-diol;
　１，２－シクロペンタンジオール、１，３－シクロペンタンジオール、１，２－シクロヘキサンジオール、１，３－シクロヘキサンジオール、１，４－シクロヘキサンジオール、１，２－シクロヘプタンジオール、２，３－ノルボルナンジオール、２，５－ノルボルナンジオール、２，７－ノルボルナンジオール、１，２－シクロオクタンジオール、１，４－シクロオクタンジオール、１，２－シクロデカンジオール、５－シクロオクテン－１，２－ジオール、１，５－デカリンジオール、リモネングリコール、１，２－テルペンジオール、４，４’－ビシクロヘキサンジオール、１，２－シクロドデカンジオール等の脂環状ジオール； 1,2-cyclopentanediol, 1,3-cyclopentanediol, 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2-cycloheptanediol, 2,3-norbornane Diol, 2,5-norbornanediol, 2,7-norbornanediol, 1,2-cyclooctanediol, 1,4-cyclooctanediol, 1,2-cyclodecanediol, 5-cyclooctene-1,2-diol Alicyclic diols such as 1,5-decalindiol, limonene glycol, 1,2-terpenediol, 4,4′-bicyclohexanediol, 1,2-cyclododecanediol;
　グリセリン、１，２，３－ブタントリオール、１，２，４－ブタントリオール、２－メチル－１，２，３－プロパントリオール、１，２，３－ペンタントリオール、１，２，４－ペンタントリオール、１，３，５－ペンタントリオール、２，３，４－ペンタントリオール、２－メチル－２，３，４－ブタントリオール、トリメチロールエタン、２，３，４－ヘキサントリオール、２－エチル－１，２，３－ブタントリオール、トリメチロールプロパン、４－プロピル－３，４，５－ヘプタントリオール、２，４－ジメチル－２，３，４－ペンタントリオール、トリエタノールアミン、トリイソプロパノールアミン等の３価アルコール； Glycerin, 1,2,3-butanetriol, 1,2,4-butanetriol, 2-methyl-1,2,3-propanetriol, 1,2,3-pentanetriol, 1,2,4-pentanetriol 1,3,5-pentanetriol, 2,3,4-pentanetriol, 2-methyl-2,3,4-butanetriol, trimethylolethane, 2,3,4-hexanetriol, 2-ethyl-1 , 2,3-butanetriol, trimethylolpropane, 4-propyl-3,4,5-heptanetriol, 2,4-dimethyl-2,3,4-pentanetriol, triethanolamine, triisopropanolamine, etc. Alcohols;
　エリスリトール、ペンタエリスリトール、１，２，３，４－ペンタテトロール、２，３，４，５－ヘキサテトロール、１，２，４，５－ペンタンテトロール、１，３，４，５－ヘキサンテトロール、ジグリセリン、ソルビタン、Ｎ，Ｎ，Ｎ',Ｎ'－テトラキス（２－ヒドロキシプロピル）エチレンジアミン、Ｎ，Ｎ，Ｎ',Ｎ'－テトラキス（ヒドロキシエチル）エチレンジアミン等の４価アルコール； Erythritol, pentaerythritol, 1,2,3,4-pentatetrol, 2,3,4,5-hexatetrol, 1,2,4,5-pentanetetrol, 1,3,4,5-hexane Tetrahydric alcohols such as tetrol, diglycerin, sorbitan, N, N, N ′, N′-tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N ′, N′-tetrakis (hydroxyethyl) ethylenediamine;
　アドニトール、アラビトール、キシリトール、トリグリセリン等の５価アルコール；
　ジペンタエリスリトール、ソルビトール、マンニトール、イジトール、イノシトール、ダルシトール、タロース、アロース等の６価アルコール； Pentahydric alcohols such as adonitol, arabitol, xylitol, triglycerin;
Hexavalent alcohols such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, dulcitol, talose, allose;
　１－メチルグリセリルエーテル、２－メチルグリセリルエーテル、１－エチルグリセリルエーテル、２－エチルグリセリルエーテル、１－プロピルグリセリルエーテル、２－プロピルグリセリルエーテル、１－イソプロピルグリセリルエーテル、２－イソプロピルグリセリルエーテル、１－ブチルグリセリルエーテル、２－ブチルグリセリルエーテル、１－イソブチルグリセリルエーテル、２－イソブチルグリセリルエーテル、１－ペンチルグリセリルエーテル、２－ペンチルグリセリルエーテル、１－ヘキシルグリセリルエーテル、２－ヘキシルグリセリルエーテル、１－ヘプチルグリセリルエーテル、２－ヘプチルグリセリルエーテル、１－オクチルグリセリルエーテル、２－オクチルグリセリルエーテル、１－（２－エチルヘキシル）グリセリルエーテル、２－（２－エチルヘキシル）グリセリルエーテル、１－ノニルグリセリルエーテル、２－ノニルグリセリルエーテル、１－デシルグリセリルエーテル、２－デシルグリセリルエーテル、１－ウンデシルグリセリルエーテル、２－ウンデシルグリセリルエーテル、１－ドデシルグリセリルエーテル、２－ドデシルグリセリルエーテル、１－トリデシルグリセリルエーテル、２－トリデシルグリセリルエーテル、１－テトラデシルグリセリルエーテル、２－テトラデシルグリセリルエーテル、１－ヘキサデシルグリセリルエーテル、２－ヘキサデシルグリセリルエーテル、１－オクタデシルグリセリルエーテル、２－オクタデシルグリセリルエーテル、１－分枝オクタデシルグリセリルエーテル、２－分枝オクタデシルグリセリルエーテル、１－エイコシルグリセリルエーテル、２－エイコシルグリセリルエーテル、１－アリルグリセリルエーテル、２－アリルグリセリルエーテル、１－ウンデセニルグリセリルエーテル、２－ウンデセニルグリセリルエーテル、１－オレイルグリセリルエーテル、２－オレイルグリセリルエーテル、２－シクロヘキシルグリセリルエーテル、２－フェニルグリセリルエーテル等のグリセリンモノエーテル類； 1-methyl glyceryl ether, 2-methyl glyceryl ether, 1-ethyl glyceryl ether, 2-ethyl glyceryl ether, 1-propyl glyceryl ether, 2-propyl glyceryl ether, 1-isopropyl glyceryl ether, 2-isopropyl glyceryl ether, 1- Butyl glyceryl ether, 2-butyl glyceryl ether, 1-isobutyl glyceryl ether, 2-isobutyl glyceryl ether, 1-pentyl glyceryl ether, 2-pentyl glyceryl ether, 1-hexyl glyceryl ether, 2-hexyl glyceryl ether, 1-heptyl glyceryl Ether, 2-heptyl glyceryl ether, 1-octyl glyceryl ether, 2-octyl glyceryl ether, 1- (2-ethylhexyl) Glyceryl ether, 2- (2-ethylhexyl) glyceryl ether, 1-nonyl glyceryl ether, 2-nonyl glyceryl ether, 1-decyl glyceryl ether, 2-decyl glyceryl ether, 1-undecyl glyceryl ether, 2-undecyl glyceryl ether 1-dodecyl glyceryl ether, 2-dodecyl glyceryl ether, 1-tridecyl glyceryl ether, 2-tridecyl glyceryl ether, 1-tetradecyl glyceryl ether, 2-tetradecyl glyceryl ether, 1-hexadecyl glyceryl ether, 2- Hexadecyl glyceryl ether, 1-octadecyl glyceryl ether, 2-octadecyl glyceryl ether, 1-branched octadecyl glyceryl ether, 2-branched octadecyl ether Seryl ether, 1-eicosyl glyceryl ether, 2-eicosyl glyceryl ether, 1-allyl glyceryl ether, 2-allyl glyceryl ether, 1-undecenyl glyceryl ether, 2-undecenyl glyceryl ether, 1-oleyl glyceryl ether Glycerol monoethers such as 2-oleyl glyceryl ether, 2-cyclohexyl glyceryl ether, 2-phenyl glyceryl ether;
　Ｎ－メチルジエタノールアミン、Ｎ－エチルジエタノールアミン、Ｎ－プロピルジエタノールアミン、Ｎ－イソプロピルジエタノールアミン、Ｎ－ブチルジエタノールアミン、Ｎ－シクロヘキシルジエタノールアミン、Ｎ－（２－エチルヘキシル）ジエタノールアミン等のＮ－置換ジエタノールアミン類； N-substituted diethanolamines such as N-methyldiethanolamine, N-ethyldiethanolamine, N-propyldiethanolamine, N-isopropyldiethanolamine, N-butyldiethanolamine, N-cyclohexyldiethanolamine, N- (2-ethylhexyl) diethanolamine;
　Ｎ－メチルジイソプロパノールアミン、Ｎ－エチルジイソプロパノールアミン、Ｎ－プロピルジイソプロパノールアミン、Ｎ－イソプロピルジイソプロパノールアミン、Ｎ－ブチルジイソプロパノールアミン、Ｎ－シクロヘキシルジイソプロパノールアミン、Ｎ－（２－エチルヘキシル）ジイソプロパノールアミン等のＮ－置換ジイソプロパノールアミン類； N-methyldiisopropanolamine, N-ethyldiisopropanolamine, N-propyldiisopropanolamine, N-isopropyldiisopropanolamine, N-butyldiisopropanolamine, N-cyclohexyldiisopropanolamine, N- (2-ethylhexyl) di N-substituted diisopropanolamines such as isopropanolamine;
　３－ジメチルアミノ－１，２－プロパンジオール、３－ジエチルアミノ－１，２－プロパンジオール、３－ジプロピルアミノ－１，２－プロパンジオール、３－ジイソプロピルアミノ－１，２－プロパンジオール、３－ジブチルアミノ－１，２－プロパンジオール等のＮ，Ｎ－ジ置換－３－アミノ－１，２－プロパンジオール類が挙げられる。 3-dimethylamino-1,2-propanediol, 3-diethylamino-1,2-propanediol, 3-dipropylamino-1,2-propanediol, 3-diisopropylamino-1,2-propanediol, 3- And N, N-disubstituted-3-amino-1,2-propanediols such as dibutylamino-1,2-propanediol.
　これらの低分子ポリオールの中でも、エチレングリコール、ジエチレングリコール、トリエチレングリコール、プロピレングリコール、ジプロピレングリコール、トリプロピレングリコール、１，２－ブタンジオール、１，３－ブタンジオール、２，３－ブタンジオール、３－メチル－１，３ブタンジオール、２－エチル－１，３－ヘキサンジオール、２－ブチル－２－エチル－１，３－プロパンジオール、１，１０－デカンジオール、グリセリン、トリエタノールアミン、トリイソプロパノールアミン、エリスリトール、ジグリセリン、ソルビタン、Ｎ，Ｎ，Ｎ',Ｎ'－テトラキス（２－ヒドロキシプロピル）エチレンジアミン、Ｎ，Ｎ，Ｎ',Ｎ'－テトラキス（ヒドロキシエチル）エチレンジアミン、ソルビトール、１－メチルグリセリルエーテル、１－エチルグリセリルエーテル、１－プロピルグリセリルエーテル、１－ブチルグリセリルエーテル、１－アリルグリセリルエーテルが好ましく、エチレングリコール、ジエチレングリコール、トリエチレングリコール、プロピレングリコール、ジプロピレングリコール、トリプロピレングリコール、１，３－ブタンジオール、３－メチル－１，３ブタンジオール、グリセリン、トリエタノールアミン、ジグリセリン、ソルビタン、Ｎ，Ｎ，Ｎ',Ｎ'－テトラキス（２－ヒドロキシプロピル）エチレンジアミン、ソルビトール、１－アリルグリセリルエーテルがより好ましく、プロピレングリコール、ジプロピレングリコール、１，３－ブタンジオール、３－メチル－１，３ブタンジオール、グリセリン、ソルビトール、１－アリルグリセリルエーテルが更に好ましい。 Among these low molecular polyols, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,2-butanediol, 1,3-butanediol, 2,3-butanediol, 3 -Methyl-1,3-butanediol, 2-ethyl-1,3-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 1,10-decanediol, glycerin, triethanolamine, triisopropanol Amine, erythritol, diglycerin, sorbitan, N, N, N ′, N′-tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N ′, N′-tetrakis (hydroxyethyl) ethylenediamine, sorbitol, 1-methyl Glyceryl Ether, 1-ethyl glyceryl ether, 1-propyl glyceryl ether, 1-butyl glyceryl ether, 1-allyl glyceryl ether are preferred, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1, 3-butanediol, 3-methyl-1,3-butanediol, glycerin, triethanolamine, diglycerin, sorbitan, N, N, N ′, N′-tetrakis (2-hydroxypropyl) ethylenediamine, sorbitol, 1-allyl Glyceryl ether is more preferable, propylene glycol, dipropylene glycol, 1,3-butanediol, 3-methyl-1,3-butanediol, glycerin, sorbitol, 1-allyl Li glyceryl ether is more preferable.
　低分子ポリオールの配合量は特に限定されないが、低分子ポリオールがあまりに少ないと抗菌性の向上効果が得られない場合があり、あまりに多いと添加量にみあう抗菌性の向上がえられなくなることから、低分子ポリオールの配合量は、（Ａ）成分１００質量部に対して０．５～５００質量部が好ましく、１～２００質量部が更に好ましく、２～１００質量部がさらにより好ましく、１０～７５質量部が特に好ましい。 The blending amount of the low molecular polyol is not particularly limited, but if the amount of the low molecular polyol is too small, the antibacterial improvement effect may not be obtained, and if the amount is too large, the antibacterial improvement corresponding to the added amount cannot be obtained. The blending amount of the low molecular polyol is preferably 0.5 to 500 parts by weight, more preferably 1 to 200 parts by weight, still more preferably 2 to 100 parts by weight, based on 100 parts by weight of the component (A). 75 parts by mass is particularly preferred.
　窒素含有ノニオン界面活性剤としては、例えば、以下の一般式（２）～（８）で表される化合物が挙げられる。 Examples of the nitrogen-containing nonionic surfactant include compounds represented by the following general formulas (2) to (8).
Figure JPOXMLDOC01-appb-C000004
Figure JPOXMLDOC01-appb-C000004
（式中、Ｒ2はアルキル基又はアルケニル基を表わし、Ｒ3はアルキル基、アルケニル基又は－(ＣＨ2ＣＨ2Ｏ)b－Ｈで表わされる基を表わし、ａおよびｂはそれぞれ１～２０の数を表わす。） (Wherein R 2 represents an alkyl group or an alkenyl group, R 3 represents an alkyl group, an alkenyl group or a group represented by — (CH 2 CH 2 O) b —H, and a and b are each from 1 to 20) Represents the number of
Figure JPOXMLDOC01-appb-C000005
Figure JPOXMLDOC01-appb-C000005
（式中、Ｒ4はアルキル基又はアルケニル基を表わし、ｃ、ｄ及びｅはそれぞれ１～２０の数を表わし、ｆは２～３の数を表わす。） (Wherein, R 4 represents an alkyl group or an alkenyl group, c, d and e represent the number of each 1 ~ 20, f represents a number of 2-3.)
Figure JPOXMLDOC01-appb-C000006
Figure JPOXMLDOC01-appb-C000006
（式中、Ｒ5はアルキル基又はアルケニル基を表わす。） (In the formula, R 5 represents an alkyl group or an alkenyl group.)
Figure JPOXMLDOC01-appb-C000007
Figure JPOXMLDOC01-appb-C000007
（式中、Ｒ6はアルキル基又はアルケニル基を表わし、Ｒ7は水素原子、炭素数１～４のアルキル基又は－(Ｒ9Ｏ)h－Ｈで表わされる基を表わし、Ｒ8及びＲ9はそれぞれ炭素数２～３のアルキレン基を表わし、ｇ及びｈはそれぞれ独立に１～２０の数を表わす。） (Wherein R 6 represents an alkyl group or an alkenyl group, R 7 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group represented by — (R 9 O) h —H, R 8 and R 9 represents an alkylene group having 2 to 3 carbon atoms, and g and h each independently represents a number of 1 to 20)
Figure JPOXMLDOC01-appb-C000008
Figure JPOXMLDOC01-appb-C000008
（式中、Ｒ10及びＲ11は、エチレン基又はプロピレン基を表わし、ｊ及びｋはそれぞれ独立した１～２００の数を表わす。ただし、Ｒ10及びＲ11が同じ基になることはない。） (Wherein R 10 and R 11 represent an ethylene group or a propylene group, and j and k each represent an independent number of 1 to 200, provided that R 10 and R 11 are not the same group. )
Figure JPOXMLDOC01-appb-C000009
Figure JPOXMLDOC01-appb-C000009
（式中、Ｒ12は、アルキル基又はアルケニル基を表わす。） (In the formula, R 12 represents an alkyl group or an alkenyl group.)
Figure JPOXMLDOC01-appb-C000010
Figure JPOXMLDOC01-appb-C000010
（式中、Ｒ13は、アルキル基又はアルケニル基を表わし、ｍは２又は３の数を表わす。） (In the formula, R 13 represents an alkyl group or an alkenyl group, and m represents a number of 2 or 3.)
　一般式（２）において、Ｒ2はアルキル基又はアルケニル基を表わし、Ｒ3はアルキル基、アルケニル基又は－(ＣＨ2ＣＨ2Ｏ)b－Ｈで表わされる基を表わし、ａおよびｂはそれぞれ１～２０の数を表わす。Ｒ2は炭素数８～２２のアルキル基又はアルケニル基が好ましく、炭素数１２～１８のアルキル基又はアルケニル基が更に好ましい。また、Ｒ3は－(ＣＨ2ＣＨ2Ｏ)b－Ｈで表わされる基が好ましい。ａ及びｂは、ａ及びｂの合計の値が２～１０の数であることが好ましく、２～４の数であることがより好ましい。 In the general formula (2), R 2 represents an alkyl group or an alkenyl group, R 3 represents an alkyl group, an alkenyl group or a group represented by — (CH 2 CH 2 O) b —H, and a and b are respectively Represents a number from 1 to 20. R 2 is preferably an alkyl group or alkenyl group having 8 to 22 carbon atoms, and more preferably an alkyl group or alkenyl group having 12 to 18 carbon atoms. R 3 is preferably a group represented by — (CH 2 CH 2 O) b —H. For a and b, the total value of a and b is preferably a number of 2 to 10, more preferably a number of 2 to 4.
　一般式（３）において、Ｒ4はアルキル基又はアルケニル基を表わし、ｃ、ｄ及びｅはそれぞれ１～２０の数を表わし、ｆは２～３の数を表わす。Ｒ4は炭素数８～２２のアルキル基又はアルケニル基が好ましく、炭素数１２～１８のアルキル基又はアルケニル基より好ましい。ｃ、ｄ及びｅは、ｃ、ｄ及びｅの合計の値が３～１０の数であることが好ましく、３～５の数であることがより好ましい。また、ｆは２～３の数が好ましく、３の数がより好ましい。 In general formula (3), R 4 represents an alkyl group or an alkenyl group, c, d and e represent the number of each 1 ~ 20, f represents a number of 2-3. R 4 is preferably an alkyl group or alkenyl group having 8 to 22 carbon atoms, and more preferably an alkyl group or alkenyl group having 12 to 18 carbon atoms. For c, d and e, the total value of c, d and e is preferably a number of 3 to 10, more preferably a number of 3 to 5. Further, f is preferably a number of 2 to 3, more preferably a number of 3.
　一般式（４）において、Ｒ5はアルキル基又はアルケニル基を表わす。Ｒ5は炭素数８～２２のアルキル基又はアルケニル基が好ましく、炭素数９～１８のアルキル基又はアルケニル基がより好ましく、炭素数１０～１４のアルキル基又はアルケニル基が更に好ましい。 In the general formula (4), R 5 represents an alkyl group or an alkenyl group. R 5 is preferably an alkyl group or alkenyl group having 8 to 22 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 18 carbon atoms, and further preferably an alkyl group or alkenyl group having 10 to 14 carbon atoms.
　一般式（５）において、Ｒ6はアルキル基又はアルケニル基を表わし、Ｒ7は水素原子、炭素数１～４のアルキル基又は－(Ｒ9Ｏ)h－Ｈで表わされる基を表わし、Ｒ8及びＲ9はそれぞれ炭素数２～３のアルキレン基を表わし、ｇ及びｈはそれぞれ独立に１～２０の数を表わす。Ｒ6は炭素数７～２１のアルキル基又はアルケニル基が好ましく、炭素数９～１７のアルキル基又はアルケニル基がより好ましく、炭素数１１～１３のアルキル基が更に好ましい。また、Ｒ7は水素原子、メチル基、－ＣＨ2ＣＨ2ＯＨが好ましく、水素原子、メチル基がより好ましい。Ｒ7が水素原子の場合、ｇは１～３の数が好ましく、Ｒ8がエチレン基でｇが１であることがより好ましい。Ｒ7がメチル基の場合、Ｒ8がエチレン基であることが好ましく、Ｒ8がエチレン基でｇが１であることがより好ましい。Ｒ7が－ＣＨ2ＣＨ2ＯＨの場合は、Ｒ8がエチレン基でｇが１であることが好ましい。また、ｈは１であることが好ましい。 In the general formula (5), R 6 represents an alkyl group or an alkenyl group, R 7 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group represented by — (R 9 O) h —H; 8 and R 9 each represent an alkylene group having 2 to 3 carbon atoms, and g and h each independently represents a number from 1 to 20. R 6 is preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 17 carbon atoms, and still more preferably an alkyl group having 11 to 13 carbon atoms. R 7 is preferably a hydrogen atom, a methyl group or —CH 2 CH 2 OH, more preferably a hydrogen atom or a methyl group. When R 7 is a hydrogen atom, g is preferably a number from 1 to 3, more preferably R 8 is an ethylene group and g is 1. When R 7 is a methyl group, R 8 is preferably an ethylene group, more preferably R 8 is an ethylene group and g is 1. When R 7 is —CH 2 CH 2 OH, R 8 is preferably an ethylene group and g is 1. H is preferably 1.
　一般式（６）において、Ｒ10及びＲ11は、エチレン基又はプロピレン基を表わし、ｊ及びｋは０ではなく、それぞれ独立した１～２００の数を表す。Ｒ10がプロピレン基でＲ11がエチレン基であることが好ましい。また、ｊは７～２５の数であることが好ましく、１０～１５の数がより好ましく、１１～１３の数が更に好ましい。更に、ｊの値がｋの値に対して、１０～２００％が好ましく、２０～１５０％がより好ましく、５０～１００％が更に好ましい。 In the general formula (6), R 10 and R 11 represent an ethylene group or a propylene group, and j and k are not 0, and each represents an independent number of 1 to 200. R 10 is preferably a propylene group and R 11 is preferably an ethylene group. J is preferably a number from 7 to 25, more preferably a number from 10 to 15, and still more preferably a number from 11 to 13. Further, the value of j is preferably 10 to 200%, more preferably 20 to 150%, and still more preferably 50 to 100% with respect to the value of k.
　一般式（７）において、Ｒ12は、アルキル基又はアルケニル基を表わす。Ｒ12は炭素数９～１８のアルキル基又はアルケニル基が好ましく、炭素数１０～１６のアルキル基がより好ましく、炭素数１０～１４のアルキル基が更に好ましい。 In the general formula (7), R 12 represents an alkyl group or an alkenyl group. R 12 is preferably an alkyl group or alkenyl group having 9 to 18 carbon atoms, more preferably an alkyl group having 10 to 16 carbon atoms, and further preferably an alkyl group having 10 to 14 carbon atoms.
　一般式（８）において、Ｒ13は、アルキル基又はアルケニル基を表わし、ｍは２又は３の数を表わす。Ｒ13は炭素数８～１７のアルキル基又はアルケニル基が好ましく、炭素数９～１５のアルキル基又はアルケニル基がより好ましく、炭素数９～１３のアルキル基が更に好ましい。また、ｍは３の数が好ましい。 In the general formula (8), R 13 represents an alkyl group or an alkenyl group, and m represents a number of 2 or 3. R 13 is preferably an alkyl group or alkenyl group having 8 to 17 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, more preferably an alkyl group having a carbon number of 9-13. Further, m is preferably a number of 3.
　これらの窒素含有ノニオン界面活性剤の中でも、一般式（２）、（４）、（５）、（７）で表わされた化合物が好ましく、一般式（２）、（５）、（７）がより好ましく、一般式（５）が最も好ましい。 Among these nitrogen-containing nonionic surfactants, compounds represented by the general formulas (2), (4), (5) and (7) are preferable, and the general formulas (2), (5) and (7) Is more preferable, and general formula (5) is most preferable.
　窒素含有ノニオン界面活性剤の配合量は特に限定されないが、窒素含有ノニオン界面活性剤があまり少ないと抗菌性の向上効果が得られない場合があり、あまり多いと配合量にみあう増量効果が得られなくなるため、窒素含有ノニオン界面活性剤の配合量は、（Ａ）成分１００質量部に対して０．５～５００質量部が好ましく、１～２００質量部が更に好ましく、２～１００質量部がさらにより好ましく、１０～７５質量部が特に好ましい。 The blending amount of the nitrogen-containing nonionic surfactant is not particularly limited, but if the nitrogen-containing nonionic surfactant is too small, the antibacterial improvement effect may not be obtained, and if it is too large, the effect of increasing the amount to match the blending amount is obtained. Therefore, the blending amount of the nitrogen-containing nonionic surfactant is preferably 0.5 to 500 parts by weight, more preferably 1 to 200 parts by weight, and more preferably 2 to 100 parts by weight with respect to 100 parts by weight of the component (A). Even more preferred is 10 to 75 parts by weight.
　窒素含有両性界面活性剤としては、例えば、以下の一般式（９）～（１４）で表わされる化合物が挙げられる： Examples of the nitrogen-containing amphoteric surfactant include compounds represented by the following general formulas (9) to (14):
Figure JPOXMLDOC01-appb-C000011
Figure JPOXMLDOC01-appb-C000011
（Ｒ14はアルキル基を表わし、ｎは１～３の数を表わす。） (R 14 represents an alkyl group, and n represents a number of 1 to 3)
Figure JPOXMLDOC01-appb-C000012
Figure JPOXMLDOC01-appb-C000012
（Ｒ15はアルキル基又はアルケニル基を表わし、ｐは２～３の数を表わす。） (R 15 represents an alkyl group or an alkenyl group, and p represents a number of 2 to 3)
Figure JPOXMLDOC01-appb-C000013
Figure JPOXMLDOC01-appb-C000013
（Ｒ16はアルキル基又はアルケニル基を表わし、ｑは２～３の数を表わす。） (R 16 represents an alkyl group or an alkenyl group, and q represents a number of 2 to 3)
Figure JPOXMLDOC01-appb-C000014
Figure JPOXMLDOC01-appb-C000014
（Ｒ17はアルキル基又はアルケニル基を表わす。） (R 17 represents an alkyl group or an alkenyl group.)
Figure JPOXMLDOC01-appb-C000015
Figure JPOXMLDOC01-appb-C000015
（Ｒ18はアルキル基又はアルケニル基を表わし、ｒは２～３の数を表わす。） (R 18 represents an alkyl group or an alkenyl group, and r represents a number of 2 to 3)
Figure JPOXMLDOC01-appb-C000016
Figure JPOXMLDOC01-appb-C000016
（Ｒ19はアルキル基又はアルケニル基を表わし、ｓは２～３の数を表わす。） (R 19 represents an alkyl group or an alkenyl group, and s represents a number of 2 to 3)
　一般式（９）において、Ｒ14はアルキル基を表わし、ｎは１～３の数を表わす。Ｒ14は炭素数９～１８のアルキル基が好ましく、炭素数１０～１６のアルキル基がより好ましく、炭素数１０～１４のアルキル基が更に好ましい。また、ｎの値は１が好ましい。 In the general formula (9), R 14 represents an alkyl group, and n represents a number of 1 to 3. R 14 is preferably an alkyl group having 9 to 18 carbon atoms, more preferably an alkyl group having 10 to 16 carbon atoms, and further preferably an alkyl group having 10 to 14 carbon atoms. The value of n is preferably 1.
　一般式（１０）において、Ｒ15はアルキル基又はアルケニル基を表わし、ｐは２～３の数を表わす。Ｒ15は炭素数７～２１のアルキル基又はアルケニル基が好ましく、炭素数９～１５のアルキル基又はアルケニル基がより好ましく、炭素数９～１３のアルキル基が更に好ましい。また、ｐは３の数が好ましい。 In the general formula (10), R 15 represents an alkyl or alkenyl group, p is a number from 2-3. R 15 is preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and still more preferably an alkyl group having 9 to 13 carbon atoms. Further, p is preferably a number of 3.
　一般式（１１）において、Ｒ16はアルキル基又はアルケニル基を表わし、ｑは２～３の数を表わす。Ｒ16は炭素数７～２１のアルキル基又はアルケニル基が好ましく、炭素数９～１５のアルキル基又はアルケニル基がより好ましく、炭素数９～１３のアルキル基が更に好ましい。また、ｑは３の数が好ましい。 In the general formula (11), R 16 represents an alkyl group or an alkenyl group, and q represents a number of 2 to 3. R 16 is preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and still more preferably an alkyl group having 9 to 13 carbon atoms. Further, q is preferably a number of 3.
　一般式（１２）において、Ｒ17はアルキル基又はアルケニル基を表わし、炭素数７～２１のアルキル基又はアルケニル基が好ましく、炭素数９～１５のアルキル基又はアルケニル基がより好ましく、炭素数９～１３のアルキル基が更に好ましい。 In the general formula (12), R 17 represents an alkyl group or an alkenyl group, preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and a carbon number of 9 More preferred is an alkyl group of ˜13.
　一般式（１３）において、Ｒ18はアルキル基又はアルケニル基を表わし、ｒは２～３の数を表わす。Ｒ18は炭素数８～１８のアルキル基又はアルケニル基が好ましく、炭素数１０～１６のアルキル基又はアルケニル基がより好ましく、炭素数１０～１４のアルキル基が更に好ましい。また、ｒは３の数が好ましい。 In the general formula (13), R 18 represents an alkyl group or an alkenyl group, and r represents a number of 2 to 3. R 18 is preferably an alkyl group or alkenyl group having 8 to 18 carbon atoms, more preferably an alkyl group or alkenyl group having 10 to 16 carbon atoms, more preferably an alkyl group having 10 to 14 carbon atoms. R is preferably a number of 3.
　一般式（１４）において、Ｒ19はアルキル基又はアルケニル基を表わし、ｓは２～３の数を表わす。Ｒ19は炭素数７～２１のアルキル基又はアルケニル基が好ましく、炭素数９～１５のアルキル基又はアルケニル基がより好ましく、炭素数９～１３のアルキル基が更に好ましい。また、ｓは３の数が好ましい。 In the general formula (14), R 19 represents an alkyl group or an alkenyl group, and s represents a number of 2 to 3. R 19 is preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and further preferably an alkyl group having 9 to 13 carbon atoms. Further, s is preferably a number of 3.
　これらの窒素含有両性界面活性剤の中でも、一般式（９）、（１０）、（１１）で表わされた化合物が好ましく、一般式（１０）、（１１）がより好ましく、一般式（１０）が最も好ましい。 Among these nitrogen-containing amphoteric surfactants, compounds represented by general formulas (9), (10), and (11) are preferable, general formulas (10) and (11) are more preferable, and general formula (10 ) Is most preferred.
　窒素含有両性界面活性剤の配合量は特に限定されないが、窒素含有両性界面活性剤があまり少ないと抗菌性の向上効果が得られない場合があり、あまり多いと配合量にみあう増量効果が得られなくなるため、窒素含有両性界面活性剤の配合量は、（Ａ）成分１００質量部に対して０．５～５００質量部が好ましく、１～２００質量部が更に好ましく、２～１００質量部がさらにより好ましく、１０～７５質量部が特に好ましい。 The compounding amount of the nitrogen-containing amphoteric surfactant is not particularly limited, but if the amount of the nitrogen-containing amphoteric surfactant is too small, the antibacterial effect may not be obtained. Therefore, the blending amount of the nitrogen-containing amphoteric surfactant is preferably 0.5 to 500 parts by weight, more preferably 1 to 200 parts by weight, and more preferably 2 to 100 parts by weight with respect to 100 parts by weight of the component (A). Even more preferred is 10 to 75 parts by weight.
　本発明において、植物由来エキスとは、植物または藻類または菌類の全部、または花、葉、茎、果実、樹皮、根、種、樹脂等の特定の部位を、そのまま、又は圧搾、乾燥粉砕若しくは発酵等を加えてから、常温又は加温下で溶媒により抽出することにより得られるもので、水、エタノール、プロピレングリコール又は油脂に溶解するものをいう。あるいは、該抽出液を希釈し、濃縮し、または乾燥したものでもよい。さらに、水蒸気蒸留法、抽出法、クロマトグラフィー法等を用いて精油としたものでもよい。 In the present invention, the plant-derived extract refers to the whole plant or algae or fungi, or specific parts such as flowers, leaves, stems, fruits, bark, roots, seeds, resins, etc., as they are, or pressed, dried, ground or fermented. Is obtained by extraction with a solvent at room temperature or under heating, and is soluble in water, ethanol, propylene glycol or oils and fats. Alternatively, the extract may be diluted, concentrated or dried. Further, it may be an essential oil obtained by using a steam distillation method, an extraction method, a chromatography method or the like.
　抽出溶媒としては、通常天然物成分の抽出に用いられるもの、例えば水；メタノール、エタノール、プロパノール、ブタノール等のアルコール類；エチレングリコール、プロピレングリコール、ブチレングリコール、グリセリン等の多価アルコール；アセトン、メチルエチルケトン等のケトン類；酢酸メチル、酢酸エチル等のエステル類；テトラヒドロフラン、ジエチルエーテル、ポリエチレングリコール等のエーテル類；ジクロロエタン、クロロホルム等のハロゲン化炭化水素類；石油エーテル、ｎ－ヘキサン、シクロヘキサン等の脂肪族炭化水素類；トルエン等の芳香族炭化水素類；ピリジン類；塩化ナトリウム溶液等が挙げられ、特に、水、エタノール、プロピレングリコール、ブチレングリコールが好ましい。 As an extraction solvent, those usually used for extraction of natural product components, such as water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as ethylene glycol, propylene glycol, butylene glycol and glycerin; acetone and methyl ethyl ketone Ketones such as methyl acetate and ethyl acetate; ethers such as tetrahydrofuran, diethyl ether and polyethylene glycol; halogenated hydrocarbons such as dichloroethane and chloroform; aliphatics such as petroleum ether, n-hexane and cyclohexane Hydrocarbons; aromatic hydrocarbons such as toluene; pyridines; sodium chloride solution, and the like. Water, ethanol, propylene glycol, and butylene glycol are particularly preferable.
　植物由来エキスとして使用できる植物としては、例えば、アーチチョーク、アーモンド、アイ、アイセンハルドチアポリスタキア、アイブライト、アオノリュウゼツラン、アオモジ、アカシアコンシナ、アカシアセネガル、アカシアセネガルガム、アカシアデクレンス、アカツメクサ、アカハルニレ、アカヤジオウ、アギ、アグリモニアエウパトリア、アケビ、アサガオカラクサ、アザミ、アシ、アシタバ、アジュガツルケスタニカ、アズキ、アスナロ、アスパラガス、アスパラサスリネアリス、アセロラ、アセンヤク、アセンヤクノキ、アトラスシーダー、アニス、アノゲイススレイオカルプス、アベナストリゴサ、アボカド、アマ、アマチャ、アマチャヅル、アマドコロ、アマモ、アミリスバルサミフェラ、アメリカサイカチ、アメリカサンショウ、アメリカショウマ、アメリカニンジン、アモムムアロマチクム、アラカシ、アルカナ、アルクチウムマジュス、アルクチウムミヌス、アルニカ、アルニカカミソニス、アルピニアオフィシナルム、アルファルファ（別名ムラサキウマゴヤシ）、アロエベラ、アンザンジュ、アンズ、アンゼリカ、アンチリスブルネラリア、アンペロプシスグロセデンタタ、アンマロク、イカリソウ、イザヨイバラ、イタドリ、イタリアイトスギ、イチゴ、イチジク、イチヤクソウ、イチョウ、イトラン、イナゴマメ、イブキトラノオ、イモセミル、イラクサ、イランイラン、イリス、イリスパリダ、イワベンケイ、イワミツバ、インゲンマメ、ウイキョウ、ウィタニアソムニフェラ、ウコン、ウスバサイシン、ウツボグサ、ウド、ウミクロウメモドキ、ウメ、ウヤク、ウラルカンゾウ、ウリ、ウルバラクツカ、ウルムスダビディアナ、ウンカリアトメントサ、ウンシュウミカン、エイジツ、エイランタイ、エーデルワイス、エゾウコギ、エゾヘビイチゴ、エゾミソハギ、エチナシ、エチナセアパリダ、エニシダ、エビネ、エブリコ、エルム、エレミ、エンジュ、エンドウ、エンピツビャクシン、エンメイソウ、オウシュウヨモギ、オウレン、オオアザミ、オオウメガサソウ、オオエゾデンダ、オオカラスノエンドウ、オーキスマクラタ、オーキスマスクラ、オーキッド、 Plants that can be used as plant-derived extracts include, for example, arch chalk, almond, eye, Aisenhard thia polystacia, eyebright, blue-green agave, aomoji, acacia concina, acacia senegal, acacia senegal gum, acacia decreens, red clover, Akaharunire, Akayamajiou, Agi, Agrimonia eupatoria, Akebobi, Asagaokakaraksa, thistle, reed, ashitaba, ajugatsu kestanika, azuki, asunaro, asparagus, asparagus sine alice, acerola, asenayaku, asenayakashi, atlas Gaith Suleio Calpus, Avenas Trigosa, Avocado, Ama, Amacha, Amacharu, Amadokoro, Amamo, Amiris Balsamifera, American Pikachi, Ameri Salamander, American Shouma, American Carrot, Amomu Aromachikumu, Aracasi, Arcana, Arctium Majus, Arctium Minus, Arnica, Arnica Mysonis, Alpinia Officinalum, Alfalfa (also known as Purple Palmer), Aloe Vera, Ansanju, Apricot, angelica, anti-risbrunellaria, amperopsis grocedentata, anmarok, icarius, izayoibara, itadri, italian cedar, strawberries, figs, figs, ginkgo biloba, itlan, carob, ibukitorano, imosemyl, nettle, ylang ylang, Iris, Iris Parida, Iwabenkei, Iwamituba, common bean, fennel, witania somunifera, turmeric, usubasaicin, moray moth, udo, sea urchin Doki, Ume, Uyaku, Uralcan elephant, Uri, Urbarakutsuka, Urumus davidiana, Uncarriagementa, Eunyu mikan, Ages, Eilan Thai, Edelweiss, Ekokogi, Ezosnake strawberry, Ezo misohagi, Echinashi, Echinacea parida, Echinidae, Eneidae , Jeremiah, Enju, Pea, Empizubixin, Enmezo, Paramecium, Auren, Great Thistle, Great Scorpion, Ozodenda, Greater Pea, Okis muscara, Orchis muscara, Orchid,
オーク（別名ヨーロッパナラ）、オオグルマ、オオバナオケラ、オオバナカカオノキ、オオバナサルスベリ、オオベニミカン、オオミテングヤシ、オオミノトケイソウ、オオムギ、オールスパイス、オカゼリ、オクラ、オシロイバナ、オタネニンジン、オトギリソウ、オニゲシ、オニサルビア、オニハマダイコン、オノニス、オプンティアストレプタカンサ、オプンティアツナ、オランダカラシ、オランダシャクヤク、オリーブ、オリガヌムヘラクレオチクム、オルトシホンスタミネウス、オルメニスムルチカウリス、オレンジ、オロバンケラプム、ガーデニアタヒテンシス、カーネーション、カーヤセネガレンシス、カカオ、カキョク、カシア、カシューナット、カスカラサグラダ、カッシアイタリカ、カッパフィカスアルバレジ、カトレヤ、カナダヒドラスチス、カナリヤノキ、カニナバラ、カノコソウ、カバアナタケ、カブ、ガマ（蒲）、カミツレ（別名カモミール）、カミメボウキ、カユプテ、カラクサケマン、カラスムギ、カラトウキ、ガラナ、ガリカバラ、カリフラワー、カリン、カルーナ（別名ギョリュウモドキ）、ガルシニアカンボジア、カロット、カワラヨモギ（別名インチンコウ）、カンゾウ、カンテンイタビ、キイチゴ、キウイ、キカラスウリ、キクニガナ、キゲリアアフリカーナ、キダチアロエ、キダチハッカ、キナノキ、キノア、キハダ（別名オウバク）、キバナスズシロ、キバナノハウチワマメ、キビ、ギムネマ、キモクレン、キャッサバ、キャベツ、キャラウェー、キュウリ（別名キューカンバー）、キョウオウ、ギョリュウ、ギョリュウバイ、キラヤ、キリ、ギンバイカ（別名スイカズラ）、グアー、グァバ、クインスシード、クゥエルカスアルバ、ククイノキ、 Oak (also known as European oak), giant walnut, giant oleander, giant coconut, giant clover, giant red mandarin, giant palm tree, giant pearl millet, barley, allspice, oleander, okra, oleander, salamander, red beetle, red beetle, red spider , Opuntia Streptacansa, Opuntia Tuna, Dutch Karashi, Dutch Peonies, Olives, Origanum Herak Leochikum, Orthosiphon Stamineus, Olmenis Murchikauris, Orange, Orovan Kerapum, Gardenia Tahitensis, Carnation, Kara Sene Galensis , Cacao, oysters, cassia, cashew nuts, cascara sagrada, cassia italica, kappa ficus albaledge, cattle , Canadian hydrastis, canary tree, canina rose, valerian rose, birch bamboo, turnip, scallop (camellia), chamomile (aka chamomile), scallop, cayupte, karaksakeman, oats, karatouki, guarana, garikkabara, also known as cauliflower, karin, caro ), Garcinia Cambodia, Carrot, Kawaramugigi (also known as Inchinkou), licorice, Kantara Itabibi, Kistrawberry, Kiwi, Kikarasuuri, Kikunigana, Kigeria Africana, Kidachia Aloe, Kidachihakka, Kinanoki, Quinoa, Kihada (aka Oubakaku), Kibanasushiro Prickly Bean, Millet, Gymnema, Kimokuren, Cassava, Cabbage, Caraway, Cucumber (also known as Cucumber), Kyo-Oh, Gyoryu, Gyoryubai, Ki Ya, Kiri, myrtle (also known as honeysuckle), guar, guava, quince seed, Kuueru dregs Aruba, candlenut,
クコ、クサノオウ、クズ、クスノキ、クダモノトケイソウ、クチナシ、ウワウルシ、クマザサ、クマツヅラ、クマノギク、クミン、クラメリアトリアンドラ、クララ、グランベリー、クリスマムマリチマム、グリンデリアロブスタ、クリントニアボレアリス、クルマバソウ、クルミ、グレープフルーツ、クレマティス、クロガラシ、クログルミ、クロバナヒキオコシ、グローブ、クロフサスグリ、クロミグワ、クワ、ケイケットウ、ケイ（別名シナモン）、ゲウムウルバヌム、ゲウムリバレ、ケープアロエ、ケシ、ゲッカビジン、ゲッケイジュ、ゲットウ、ケミヤマコウゾリナ、ゲンチアナ、ゲンチアナプロストラータ、ゲンノショウコ、ケンポナシ、コウキ、コウキシタン、コウケイテン、コウスイガヤ、コウボウ、コウホネ、コーヒーノキ、コガネバナ、コクシニアインディカ、コクタン、コクレアリアオフィシナリス、コケモモ、ココヤシ、ゴショイチゴ、コショウ、コシロノセンダングサ、コチニールサボテン、コチョウセッコク、コチョウラン、コナラ、コハコベ、ゴボウ、ゴマ、コムギ、コメ、コラノキ、コリアンダー、コレウス、コレウスバルバツス、ゴレンシ、コロハ、コンズランゴ、コンフリー（別名ヒレハリソウ）、コンブレタムミクランサム、サイザルアサ、サイシン、サイペラスエスクレンタス、サイプレス、サイヨウソウ、サウスレアインボルクラタ、サキシマボタンヅル、サクラ、サクラバカンボク、ザクロ、サトウカエデ、サトウキビ、サトウマツ、サザンカ、サッサフラスノキ、サフラン、サボンソウ、サラソウジュ、サリックスニグラ、サルスベリ、サングイナリアカナデンシス、サンザシ、サンシキスミレ、サンシチニンジン、サンシュユ、サンショウ、サンペンズ、 Wolfberry, celandine, kudzu, camphor tree, damselfly, gardenia, walrus, columbine, pine moth, anemonefish, cumin, clamelatrian dorado, clara, granberry, crisma malitimum, grinderi albista, clintonia borealis, walnut, walnut, Grapefruit, clematis, black pepper, black walnut, black-bellied toad, glove, blackcurrant, black-white mulberry, mulberry, caquette, kay (aka cinnamon), geum banumum, geum rivare, cape aloe, poppy, gekkavidin, bay, ghetto, ganyama strait , Genokosho, Kemponashi, Koki, Kokushitan, Koukeiten, Kousigaiya, Koubou, Kouhone, Coffeeno , Koganebana, Coccinia indica, Cocktan, Cochlearia officinalis, Cowberry, Coco Palm, Gosho Strawberry, Pepper, Koshiro no Sendangsa, Cochineal cactus, Gypsophila, Kocho orchid, Konara, Kochakobe, Gobo, Sesame, Wheat, Rice, Colander Coleus Barbatus, Carambola, Koroha, Conzurango, Comfrey (also known as Hercules), Combretum Micrantham, Sisal Asa, Saisin, Cyperus Escrentus, Cypress, Cypress, South Rare Involcata, Saxima Button Crab, Sakura, Sakuraba Kanboku, Pomegranate, sugar maple, sugarcane, sugarcane, sasanqua, sassafrasoki, saffron, savonso, salamouju, salix nigra, salus Li, Thang Ina rear Kanaden Corporation cis, hawthorn, pansy, Panax ginseng, Cornus, pepper, Sanpenzu,
シアテアメデュラリス、シアノチスアラクノイデア、シアバターノキ、シオザキソウ、シシンブリウムイリオ、シストローズ（別名ラブダナム）、シスツスモンスペリエンシス、シスツスラダニフェルス、シソ、シチヘンゲ、シナノキ、シバムギ、ジプテリクスオドラタ、シベリアモミ、シマルバ、シミシフガダフリカ、シモツケソウ、ジャガイモ、シャクヤク、ジャスミン、ジャノヒゲ、ジャノメエリカ、シュクシャ、ジュズダマ、シュッコンカスミソウ、ジュニペルスメキシカナ、ジュンサイ、ショウガ、ショウズク（別名カルダモン）、ショウブ、ショウヨウダイオウ、シラカバ、シラン、シロガラシ、シロバナインドソケイ、シロバナルーピン、シロバナワタ、シンコナカリサヤ、シンセパルムデュルシフィクム、シンビジウム、シンプロコスラセモサ、スイートアカシア、スイカ、スイカズラ、スカビオサアルベンシス、スギナ、スクテラリアガレリクラータ、ステビア、ストローブマツ、スパイニーバンブー、スピルリナプラテンシス、スピルリナマキシマ、スベリヒユ、スペルトコムギ、スミノミザクラ、スミラックスアリストロチアエホリア、セイヨウアカネ、セイヨウアカマツ、セイヨウイソノキ、セイヨウイラクサ、セイヨウオオバコ、セイヨウオトギリソウ、セイヨウカノコソウ、セイヨウカボチャ、セイヨウカリン、セイヨウカワラニンジン、セイヨウキズタ、セイヨウグルミ、セイヨウゴマノハグサ、セイヨウサクラソウ、セイヨウサンザシ、セイヨウシナノキ、セイヨウシロヤナギ、セイヨウタンポポ、セイヨウツゲ、セイヨウトチノキ、セイヨウトネリコ、セイヨウナシ、セイヨウナツユキソウ、 Shea medullaris, Cyanothis Arachnoide, Shea butter, Shiozaki, Shisimbrium Irio, Sistrose (aka Rabdanam), Sithus monsperiensis, Sisturanifels, Perilla, Shichihenge, Shinanoki, Shibumgi, Gypterix odorata , Siberian fir, Shimalba, Shimifugadafurika, Shimotsukeso, Potato, Peonies, Jasmine, Janohige, Janome Erica, Shukusha, Juzdama, Gypsophila, Juniperus mexicana, Junsai, Ginger, Shozuk (aka Cardamom) Diou, birch, silane, white pepper, white rose, white fan lupine, white rose, cinchona karisaya, synth palm dulcificum, cymbidium, white Procosera Semosa, Sweet Acacia, Watermelon, Honeysuckle, Scabiosa Albensis, Horsetail, Scutellaria Galericulata, Stevia, Strobe Pine, Spiny Bamboo, Spirulina Platensis, Spirulina Maxima, Siberian, Spell Wheat, Sumio cherry, Sumilux Aristolochiaeolia , Acacia, Acacia, Poriaceae, Atlantic nettle, Psyllium psyllium, Hypericum perforatum, Pleurotus serrata, Pepper pumpkin, Pseudocarina, Papilio rotunda, Pleurotus edulis, Prunus prunus, Pleurotus, Prunus, Prunus, Prunus White willow, dandelion, boxwood, horse chestnut, cherry Rico, pear, meadowsweet,
セイヨウナナカマド、セイロンニッケイ、セイヨウニワトコ、セイヨウニンジンボク、セイヨウネズ、セイヨウノコギリソウ、セイヨウハシバミ、セイヨウハッカ、セイヨウヒイラギ、セイヨウミザクラ、セイヨウミヤコグサ、セイヨウメギ、セイヨウヤドリギ、セイヨウヤブイチゴ、セイロンニッケイ、セージ、セクロピアオブツシホリア、セコイアオスギ、セシルオーク、セダムプルプレウム、ゼニアオイ、セネガ、ゼラニウム、セルシジウムフロリダム、セレウスグランディフロラス、セロリ、センキュウ、センチフォリアバラ、センチペダクンニンガミー、センニンコク、センプクカ、センブリ、ソウジュツ、ソウパルメット、ソケイ、ソバ、ソラヌムリコカルプム、ダイウイキョウ、ダイコン、ダイサンチク、ダイズ、ダイダイ、タイツリオウギ、タイム、タイワンヒノキ、タカサブロウ、タチジャコウソウ、タチバナ、タブノキ、タベブイアアベラネダエ、タマサキツヅラフジ、ダマスクバラ、タマネギ、ダミアナ、タラゴン、タンジン、タンボリッサトリコフィラ、チガヤ、チャ（茶）、チャボトケイソウ、チューベロース、チョウジ、チョウセンゴミシ、チョウマメ、チリアトメントサ、ツクシメナモミツバキ、ツボクサ、ツルグミ、ツルドクダミ、ツルレイシ、ティーツリー、ディオスコレアコンポジタ、ディオスコレアビロサ、ディオスコレアメキシカナ、テウチグルミ、テコマクリアリス、テツザイノキ、デューク、デュボイシアレイカルドチ、テルミナリア、テンチャ、ドイツアヤメ、ドイツトウヒ、トウガ、トウガラシ、トウキ、トウキンセンカ、トウネズミモチ、トウヒ、トウモロコシ、トウロウソウ、トクサ、ドクダミ、ドクニンジン、トシシ（別名マメダオシ）、トショウ、トマト、トリゴネラフォエヌム、トルメンチラ、 Rowan, Ceylon Nikkei, Horse Chestnut, Carrot Box, Horsestrap, Achillea millefolium, Hazel, Prunus serrata, Holly, Prunus japonica, Prunus japonica, Prunus serrata, Prunus japonica, Prunus serrata Bushihoria, sequoia cedar, cecil oak, sedum purpleum, mallow, senega, geranium, cercidium florum, cereus grandiflorus, celery, nematode, centifolia rose, centipeda cunninghammy, senninkoku, sempukuka, assembly, Sowjutsu, Saw Palmetto, Sokei, Buckwheat, Solanum Ricocarpum, Daiwikyo, Daikon, Daisanchiku, Soybean, Daidai, Ituriogi, Thyme, Taiwan Hinoki, Takasaburo, Tachibaku Sou, Tachibana, Tabonoki, Tabebuia Abernedae, Tamasaki Shiraji, Damask Rose, Onion, Damiana, Tarragon, Tanjin, Tamborissa Trichofila, Chigaya, Cha (Chew) , Clove, dung beetle, butterfly, chili attentor, tsukushimenamo honey bee, camellia, tsurugumi, tsudukudami, tsurureishi, tea tree, dioscorea composita, dioscorea vilosa, dioscorea mexicana, teigurigumi, teko clearis, tetsuzainoki, Duke, DuBoisley Cardiochi, Terminaria, Tencha, German Iris, German Spruce, Toga, Pepper, Touki, Tokinsengka, Tou Zumimochi, spruce, corn, Tourousou, horsetail, Houttuynia, hemlock, Toshishi (aka Mamedaoshi), juniper, tomato, bird Gosnay La Foe Num, Torumenchira,
トロロアオイモドキ、ナガバギシギシ、ナギイカダ、ナス、ナズナ、ナタマメ、ナツシロギク、ナツボダイジュ、ナツメ、ナツメヤシ、ナンキョウソウ、ナンバンアイ、ナンバンクサフジ、ニオイスミレ、ニオイテンジクアオイ、ニオイヒバ、ニガヨモギ、ニクズク、ニゲラサチバ、ニュウコウジュ、ニラネギ、ニンジン、ニンニク、ニンファエアアルバ、ネナシカズラ、ノイバラ、ノウゼンハレン、ノジスミレ、ノバラ、ノボロギク、パイナップル、ハイビスカス、ハイマツ、バオバブ、バクホウシアシトリオドラ、バクモンドウ、バコパモンニエラ、ハゴロモグサ、ハス、パセリ、パチョリ、ハッカクレイシ、バッカリスゲニステロイデス、パッシフローラアラタ、ハトムギ、バナナ、ハナハッカ、ハニーサックル、バニラ、バニラタヒテンシス、ハネセンナ、パパイア、パフィオペディルムマウディアエ、ハベルレアロドペンシス、ハマナス、ハマメリス、ハヤトウリ、バラ、パリエタリア、ハリエンジュ、ハルパゴフィタム、パルマローザ、バロスマベツリナ、バンウコン、パンジー、バンバラマメ、ビート、ヒイラギメギ、ヒオウギ、ヒキオコシ、ビスナガベラ、ビターアーモンド、ビターオレンジ、ヒドラスチスカナデンシス、ヒナギク、ヒナゲシ、ビナンカズラ、ピヌスヘーダ、ヒノキ、ヒバマタ、ヒヒラギギク、ヒポファエラムノイデス、ヒマワリ、ヒメコウジ、ヒメコラ、ヒメツルニチニチソウ、ヒメナエアクルバリル、ヒメフウロ、ビャクダン、ヒヨコマメ、ヒラマメ、ヒレハリソウ、ビロウドアオイ、ピロカルプスペンナチホリウス、ビワ、ビンロウ、ファフィアパニクラタ、フウセンカズラ、プエラリアミリフィカ、フェルラガルバニフルア、フキタンポポ、ブクリョウ、フサザキスイセン、フサスグリ、フサフジウツギ、フサヌススピカツス、プチグレン、プチコペタルムオラコイデス、ブッソウゲ、ブッチャーブルーム、プテロカルプスマルスピウム、ブドウ、フトモモ、ブナ、フユザンショウ、フユボダイジュ、フラガリアチロエンシス、ブラジルナッツノキ、フランスカイガンショウ、フランスラベンダー、プランタゴアフラ、プランタゴオバタ、 Trolley, Prunus, Nagii Kada, Eggplant, Natsuna, Natsume, Natsujirigi, Natsubodaiju, Jujube, Date Palm, Nanyou, Nambanai, Nanbanksafuji, Nioisumire, Niotenjii Carrot, garlic, nymphea alba, pear arabic, white rose, nousen hallen, burdock violet, wild rose, noborgiku, pineapple, hibiscus, pine, baobab, bakuchia citriodora, bacmondow, bacopamonniera, hagoromogusa, crayfish, parsley Sugenisteroides, Passiflora arata, pearl barley, banana, hana hakka, honeysuckle, vanilla, vanilla tahi Nasis, Hanesenna, Papaya, Paphiopedilum Maudiae, Haberlea Rhodopensis, Hermanus, Hamamelis, Hayatouri, Rose, Parietalia, Harienju, Harpagophyta, Palmarosa, Baros mabetsurina, Banturmeric, Pansy, Bambara peas, Beet, Holly , Bitter almond, bitter orange, hydrassic canadensis, daisies, daisies, binankazura, pinusheda, hinoki, hibamata, daisies, hippophaerumnoides, sunflower, himekoji, himekora, himetsunichiafu Chickpeas, lentils, fins, bellows, mushrooms, pilocarps, pennachihorius, loquat, betel nuts, fat Diapanic Kurata, Fusenkazura, Pueraria Mirifica, Ferula Garvaniflua, Fuquidan Popo, Buddlefish, Fusazakiisen, Fusagisuri, Fusafujitsugi, Fusanus Spicatus, Petit Glen, Petit Petalum Orakoides, Bussouage, Buchal Bloom , Beetle, beech, scallops, scallops, fragalia chiroensis, brazil nuts, french beetle, french lavender, plantagoa hula, plantago gossip,
プランタゴプシリウム、プリムラシキメンシス、プルーン、プルヌスアフリカナ、プルヌスセロチナ、プルメリア、プレクトランツスバルバタス、ブレチアヒアシンチナ、ベイ、ヘイフラワー、ヘーゼルナッツ、ペカン、ベチベル、ヘチマ、ペニーロイヤルミント、ベニノキ、ベニバナ、ベニバナセンブリ、ペポカボチャ、ヘラオオバコ、ペラルゴニウムカピタツム、ヘリクリスムアレナリウム、ヘリクリスムアングスチホリウム、ヘリクリスムイタリクム、ベルガモット、ペルトホルムダシラチス、ペルーバルサム、ベルガモット、ベルベリスアクイホリウム、ベロニカオフィシナリス、ヘンナ、ヘンルーダ、ホウキギ、ボウシュウボク、ボウシュンカ、ホウセンカ、ホウライシダ、ホウレンソウ、ホークウィード、ホオノキ、ホクベイフウロソウ、ボコアプロウアセンシス、ボスウェリアセラタ、ホソバセンナ、ホソババレンギク、ボダイジュ、ボタン、ホップ、ポテリウムオフィシナレ、ホホバ、ポリゴナツムムルチフロルム、ボルド、ポンカン、マカデミア、マグノリアオフィシナリス、マグノリアビオンジ、マグワ、マゴジャクシ、マサキ、マダケ、マツ、マツリカ、マテチャ、マドンナリリー、マヨラナ、マリアアザミ、マルピギアグラブラ、マルメロ、マロニエ、マンゴー、マンゴスチン、マンシュウアカマツ、マンジュギク、マンダリンオレンジ、マンドレイク、ミシマサイコ、ミズハッカ、ミズレモン、ミチヤナギ、ミツガシワ、ミトラカーパススケーバー、ミモザテヌイフローラ、ミルシアリアデュビア、ミルラ（別名モツヤクジュ）、ミロタムヌスフラベリフォリア、ミロバラン、ムクロジ、ムラサキ、ムラサキシキブ、ムラサキセンブリ、ムラサキバレンギク、ムラヤコエンジー、メボウキ、メマツヨイグサ、メリアアザジラクタ、 Plantagopsisium, Primula shikimensis, prunes, prunus africana, prunus serochina, plumeria, plectrants barbatas, brethia hyacinthina, bay, hayflower, hazelnuts, pecans, vetiver, loofah, penny royal mint, samurai, safflower , Safflower assembly, peppo pumpkin, hera plantain, pelargonium capitotum, helicris arenaarium, helichry angstiholium, helichry italikum, bergamot, pertoforma dasilachis, peruvian balsam, bergamot, berberis aqua horiophysi Naris, Henna, Hen Ruda, Butterflies, Boushokuboku, Bowshunka, Binsengka, Buttercup, Spinach, Hawkweed, Honoki, Hokubeif Rhododendron, Bocoa prouasensis, Boswellia serrata, Hosobasenna, Hosobabarengiku, Bodaiju, Button, Hop, Poterium officinale, Jojoba, Polygonatum mutiflorum, Bold, Ponkan, Macadamia, Magnolia officinalis, Magnolia bionji, Magwa maggot , Masaki, madake, pine, matsurika, matecha, madonna lily, mayorana, maria thistle, marpigia grabra, quince, maroonie, mango, mangosteen, mandarin red pine, manjugiku, mandarin orange, mandrake, mishima mint, mizumachi , Mitsuga wrinkle, Mitra car pass shaver, Mimosa tenui flora, Myrcia duvia, Myrrh (aka Motsuyakuju), Milottamus Flaveli Oria, Mirobaran, soapberry, purple, Murasaki Shikibu, purple assembly, Echinacea purpurea, Murayakoenji, basil, evening primrose, Melia bruises Zillah Kuta,
メリッサ（別名コウスイハッカ）、メリロート、メロスリア、メロン、メンタアルベンシス、モウコヨモギ、モウレラフルビアチリス、モクレン、モスカータバラ、モスビーン、モツヤクジュ、モモ、モモタマナ、ヤクモソウ、ヤグルマギク、ヤシャブシ、ヤチヤナギ、ヤナギハッカ、ヤナギラン、ヤマグワ、ヤマザクラ、ヤマノイモ、ヤマヨモギ、ユウガオ、ユーカリ、ユーパトリウムアヤパナ、ユーパトリウムレバウジアヌムベルトニ、ユキノシタ、ユズ、ユソウボク、ユチャ、ユッカグラウカ、ユッカシジゲラ、ユリ、ヨウシュツルキンバイ、ヨウシュホオズキ、ヨウシュヤマゴボウ、ヨーロッパアキノキリンソウ、ヨーロッパキイチゴ、ヨーロッパグリ、ヨーロッパクロヤマナラシ、ヨーロッパシラカバ、ヨーロッパブナ、ヨーロッパマンネングサ、ヨーロッパモミ、ヨモギ、ヨモギギク、ライチー（別名レイシ）、ライマメ、ライム、ライムギ、ライラック、ラジアータマツ、ラタニア、ラッカセイ、ラナンキュラスフィカリア、ラバンデュラハイブリダ、ラフマ、ラベンダー、ラリックスエウロパエア、ラレアディバリカタ、ラレアメキシカナ、ランブータン、リソサムニウムカルカラム、リトセアグルチノサ、リュウガン、リリオスマオバタキ、リンゴ、ルイボス、ルピヌススブカルノスス、ルブスビロスス、ルムプヤン、ルリジサ、ルリヒエンソウ、レスペデザ、レセダルテオラ、レタス、レダマ、レダムパルストレ、レバノンスギ、レビスチクムオフィシナーレ、レモン、レモングラス、レンゲソウ、ローズウッド、ローズマリー、ローブッシュブルーベリー、ローマカミツレ、ローレル（別名月桂樹）、ログウッド、ロブスタコーヒーノキ、ワイルドタイム、ワサビ、ワサビダイコン、ワサビノキ、ワタスギギク、ワタフジウツギ、ワルテリアインディカ、ワレモコウ等の植物； Melissa (aka Kousuihakka), Melilot, Melosria, Melon, Mentaalbensis, Moukomugi, Mourera fulviachiris, Mokuren, Moscatara rose, Mosbean, Motsuyakuju, Peach, Momotana, Yakumoso, Yagurabiku, Yashayanagiya, Nagiyanaya, Nachiyanaya Yamazakura, Yamanomu, Yamabugu, Yugao, Eucalyptus, Yupatrium Ayapana, Yupatrium Rebaudiumum Bertoni, Yukinoshita, Yuzu, Yuzoboku, Yucha, Yucca Grauca, Yukka Shijigera, Yuri, Yuzutsurukinbai, Yoshokuzuki, Yuzu Pokeweed, European goldenrod, European raspberry, European chestnut, European black porcupine, European birch, European beech, European Mannengusa, European fir, Artemisia, Artemisia, Lychee (aka Reishi), Lima bean, Lime, Rye, Lilac, Radiata pine, Latania, Peanut, Ranunculus ficusaria, Labandula hybrida, Rahma, lavender, Larix europaea, Lareadei Barikata, Larar Mexicana, Rambutan, Lithosamnium Calcolum, Lithotheaglutinosa, Longan, Liriosma Obataki, Apple, Rooibos, Lupines Bucarnos, Lubusvilos, Lumpuyan, Borage, Rurihienso, Respedeza, Resedalteora, Lettuce , Ledam pulse train, Lebanon cedar, Levischicumumushishinare, lemon, lemongrass, forsythia, rosewood, rosemary, low bush blueberry, Makamitsure, Laurel (also known as laurel), log wood, Robusta coffee trees, wild time, wasabi, horseradish, moringa oleifera, Watasugigiku, Watafujiutsugi, badass terrier Indica, such as Burnet plants;
　アスコフィルムノドスム、アナメ、オオウキモ、オキナワモズク、ギガルチナステラータ、クジェルマニエラギラタ、サルガッスムフィリペンデュラ、サルガッスムフシフォルム、サルガッスムムティカム、スファセラリアスコパリア、デュルビレアアンタルチカ、パディナパボニカ、ヒマンタリアエロンガタ、フカスセラツス、ペルベチアカナリクラタ、マクロシスティスピリフェラ、ミツイシコンブ、ラミナリアオクロロイカ、ラミナリアクロウストニ、ラミナリアディギタータ、ラミナリアヒペルボレア、ワカメ、アスパラゴプシスアルマタ、イギス、カギイバラノリ、カタメンキリンサイ、ゲリジウムカーチラギネウム、サイミ、シマテングサ、ダルス、チノリモ、トチャカ、ポルフィリジウムクルエンタム、マルバチシマクロノリ、リソサムニウムコラリオイデス、アナアオサ、クロレラエメルソニ、クロレラピレノイドーサ、デュナリエラサリナ、デュナリエラバーダウィル、ヒラアオノリ、スピルリナプラテンシス、スピルリナマキシマ、ハスレアオストレアリア、デレセリアサングイネア、ピケアロブスタ、プリュウロクリシスカルテレ、ヘマトコッカスプルビアリス、ラン藻、コンドルスクリスプス、サンゴモ、シーウィップ、赤藻等の藻類； Asco Film Nodosum, Aname, Oukimo, Okinawa Mozuku, Gigalchinasterata, Kujermaniela Girata, Sargassum Filipendula, Sargassum Fusifom, Sargassum Muticam, Sfaceraria scoparia, Durvillea Antarcica, Padina Pavonica Himantalia Elongata, Fucus Serats, Pervetian Canarikurata, Macrocystis pirifera, Mitsushi Kombu, Laminaria Ochroika, Laminaria Croustoni, Laminaria Diguitta, Laminaria Hiperborea, Wakame, Asparagopsis Armata, Igis, Kaguibaranori , Catamen giraffe rhinoceros, geridium curchira guineum, saimi, striped primrose, duls, chinolimo, tochaka, porphyridium cruentum, marbaticima macrono , Lysosamnium coralioides, ana aosa, chlorella emersoni, chlorella pyrenoidosa, duna riela salina, duna riela berdawiru, hiraao nori, spirulina platensis, spirulina maxima, hasrea austria, dereceria sanguinea, picaroovista Algae such as cartele, Haematococcus prubiaris, cyanobacteria, condor crisps, coral, sea whip, red algae;
　エベルニアフルフラセア、ツノマタゴケ、ウスニアバルバタ、オシャグジタケ、カバアナタケ、シイタケ、ニンギョウタケ、ヒメマツタケ、フユムシナツクサタケ、カバアナタケ、チョレイマイタケ、冬虫夏草等の地衣類や菌糸類が挙げられる。 Included are lichens and mycelium such as Ebernia furfracea, Tsunotake moss, Usnia barbata, Oshagujitake, Hippopotamus, Shiitake, Ningyotake, Himematsutake, Fuyushinatsutake, Bamboo shoot, Cordillus edulis and Cordyceps.
　植物由来エキスの配合量は特に限定されないが、植物由来エキスがあまり少ないと抗菌性の向上効果が得られない場合があり、あまり多いと配合量にみあう増量効果が得られなくなるため、植物由来エキスの配合量は、（Ａ）成分１００質量部に対して０．１～１０００質量部が好ましく、０．５～２００質量部が更に好ましく、１～１００質量部が最も好ましい。 The blending amount of the plant-derived extract is not particularly limited, but if the plant-derived extract is too small, the antibacterial improvement effect may not be obtained, and if it is too large, the increase effect corresponding to the blending amount cannot be obtained. The blending amount of the extract is preferably 0.1 to 1000 parts by mass, more preferably 0.5 to 200 parts by mass, and most preferably 1 to 100 parts by mass with respect to 100 parts by mass of the component (A).
　亜鉛化合物としては、例えば、酢酸亜鉛、ラウリン酸亜鉛、ミリスチン酸亜鉛、パルミチン酸亜鉛、リシノレイン酸亜鉛、ウンデシレン酸亜鉛、アスパラギン酸亜鉛、アセチルメチオニン亜鉛、グルコン酸亜鉛、クエン酸亜鉛、ポリピロリドンカルボン酸亜鉛、ピコリン酸亜鉛等の有機酸亜鉛塩；ｐ－フェノールスルホン酸亜鉛等のスルホン酸亜鉛塩、アスコルビルリン酸亜鉛、セチルリン酸亜鉛ナトリウム、ＤＮＡ亜鉛等のリン酸エステル亜鉛塩；ジンクピリチオン等の亜鉛錯体；（銀／亜鉛／アンモニウム）ゼオライト、ケイ酸（アンモニウム／銀／亜鉛／アルミニウム）等の亜鉛担持ゼオライト；酸化アルミニウム／亜鉛、酸化アルミニウム／亜鉛／セリウム、酸化アルミニウム／亜鉛／鉄等の水酸化アルミニウム等の焼成物；硫酸亜鉛、硫化亜鉛、塩化亜鉛、臭化亜鉛、硝酸亜鉛、塩化亜鉛アンモニウム、硫酸亜鉛アルミニウム、硫酸亜鉛カリウム、ヨウ化亜鉛、塩基性炭酸亜鉛等の無機亜鉛塩；(水酸化/炭酸)(Mg/Al/亜鉛)、酸化亜鉛等が挙げられる。これらの中でも、水に溶解して亜鉛イオンになりやすい化合物が好ましく、２０℃における水１００ｇへの溶解度が５ｇ以上であることが好ましく、溶解度が１０ｇ以上であることが更に好ましい。このような亜鉛化合物としては、硫酸亜鉛、塩化亜鉛、グルコン酸亜鉛、臭化亜鉛、硝酸亜鉛、塩化亜鉛アンモニウム、硫酸亜鉛アルミニウム、硫酸亜鉛カリウム、ヨウ化亜鉛等が挙げられる。 Examples of the zinc compound include zinc acetate, zinc laurate, zinc myristate, zinc palmitate, zinc ricinoleate, zinc undecylenate, zinc aspartate, zinc acetylmethionine, zinc gluconate, zinc citrate, polypyrrolidone carboxylic acid Organic acid zinc salts such as zinc and zinc picolinate; Zinc sulfonates such as zinc p-phenolsulfonate; Zinc phosphate zinc salts such as zinc ascorbyl phosphate, sodium cetyl phosphate and DNA zinc; Zinc complexes such as zinc pyrithione Zinc supported zeolite such as (silver / zinc / ammonium) zeolite and silicic acid (ammonium / silver / zinc / aluminum); aluminum hydroxide such as aluminum oxide / zinc, aluminum oxide / zinc / cerium, aluminum oxide / zinc / iron Baked product such as sulfuric acid Inorganic zinc salts such as lead, zinc sulfide, zinc chloride, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, potassium zinc sulfate, zinc iodide, basic zinc carbonate, etc .; (hydroxide / carbonic acid) (Mg / Al / zinc), zinc oxide and the like. Among these, a compound that easily dissolves in water to become zinc ions is preferable, the solubility in 100 g of water at 20 ° C. is preferably 5 g or more, and the solubility is more preferably 10 g or more. Examples of such zinc compounds include zinc sulfate, zinc chloride, zinc gluconate, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, potassium zinc sulfate, and zinc iodide.
　亜鉛化合物の配合量は特に限定されないが、亜鉛化合物があまり少ないと抗菌性の向上効果が得られない場合があり、あまり多いと配合量にみあう増量効果が得られなくなるため、亜鉛化合物の配合量は、（Ａ）成分１００質量部に対して０．０２～１０質量部が好ましく、０．０５～５質量部が更に好ましく、０．１～２質量部が最も好ましい。 The compounding amount of the zinc compound is not particularly limited. However, if the amount of the zinc compound is too small, the antibacterial effect may not be obtained. If the amount is too large, the effect of increasing the amount according to the compounding amount cannot be obtained. The amount is preferably 0.02 to 10 parts by mass, more preferably 0.05 to 5 parts by mass, and most preferably 0.1 to 2 parts by mass with respect to 100 parts by mass of the component (A).
　これらの中でも、（Ａ）成分と（Ｂ）成分との相乗効果により特に抗菌効果が高まることから、本発明の抗菌性組成物は（Ｃ）成分として、キレート剤、低分子ポリオール（但し、（Ａ）成分に該当するジオール化合物は除く）、及び窒素含有ノニオン界面活性剤からなる群から選択される１種または２種以上の化合物を含有することが好ましく、キレート剤及び窒素含有ノニオン界面活性剤からなる群から選択される１種または２種以上の化合物を含有することが更に好ましい。 Among these, since the antibacterial effect is particularly enhanced by the synergistic effect of the component (A) and the component (B), the antibacterial composition of the present invention has a chelating agent, a low molecular polyol (however, ( A) except diol compounds corresponding to the component), and preferably one or two or more compounds selected from the group consisting of nitrogen-containing nonionic surfactants, chelating agents and nitrogen-containing nonionic surfactants More preferably, it contains one or more compounds selected from the group consisting of:
　本発明の抗菌性組成物は、均一な水溶液だけでなく乳化系でも高い抗菌効果を発揮でき乳化系の場合は、Ｏ／ＷエマルジョンでもＷ／Ｏエマルジョンでもよく、またＯ／Ｗ／Ｏエマルジョン、Ｗ／Ｏ／Ｗエマルジョンやこれらの類型でもよい。また、本発明の抗菌性組成物は、細菌だけでなく、カビ類等の真菌類に対しても高い抗菌効果を有している。 The antibacterial composition of the present invention can exhibit a high antibacterial effect not only in a uniform aqueous solution but also in an emulsifying system, and in the case of an emulsifying system, an O / W emulsion or a W / O emulsion may be used. W / O / W emulsions and these types may also be used. The antibacterial composition of the present invention has a high antibacterial effect not only on bacteria but also on fungi such as molds.
　本発明の抗菌性組成物の用途は、特に制限されず、抗菌、殺菌、消毒、防黴等の目的で、公知の抗菌剤、殺菌剤、消毒剤、防黴剤と同様に使用することができる。例えば、抗菌処理を施したい対象物にスプレーする方法、塗布する方法、対象物に含浸させる方法、対象物を浸漬させる方法等、通常採用される方法をそのまま用いることができる。又、用途として、本発明の抗菌性組成物が、医療器具類や患部の消毒洗浄を目的とする医療用洗浄剤、食器等を殺菌洗浄する家庭用洗浄剤、食品工業用洗浄剤、容器移送コンベア用潤滑剤、食品包装フィルム、繊維、合成樹脂、木材、日用品等を抗菌加工するための抗菌剤、身体洗浄剤、化粧料、衣料用柔軟剤、水性若しくは非水性塗料、不織布等に含浸させたウェットティッシュや便座クリーナー、繊維用抗菌剤として使用する場合は、綿、ポリエステル、アクリル、ナイロン等のあらゆる繊維について、攪拌処理、浸漬処理、スプレー処理等の一般的方法で処理すればよい。又、木材、日用品等には、本発明の抗菌性組成物を表面に塗布又は噴霧することもできる。更に、合成樹脂等について使用する場合は、成形後に本発明の抗菌性組成物を塗布若しくは噴霧することにより表面に付着させてもよいし、抗菌効果を持続させるために成形加工時等に練り込むこともできる。これらの中でも、本発明の抗菌性組成物は人体に対する安全性が高いことから、化粧料や身体洗浄剤等の人体に直接触れるものに使用することが好ましく、顔面に使用する化粧料や身体洗浄剤に使用することが更に好ましい。 The use of the antibacterial composition of the present invention is not particularly limited, and can be used in the same manner as known antibacterial agents, disinfectants, disinfectants, and antifungal agents for the purpose of antibacterial, sterilization, disinfection, antifungal and the like. it can. For example, commonly employed methods such as a method of spraying on an object to be subjected to antibacterial treatment, a method of applying, a method of impregnating the object, and a method of immersing the object can be used as they are. In addition, as an application, the antibacterial composition of the present invention is a medical cleaning agent for the purpose of disinfecting and cleaning medical instruments and affected parts, a household cleaning agent for sterilizing and cleaning dishes, a food industry cleaning agent, a container transfer Impregnating lubricants for conveyors, food packaging films, fibers, synthetic resins, wood, antibacterials for antibacterial processing of daily necessities, body cleaners, cosmetics, softeners for clothing, aqueous or non-aqueous paints, non-woven fabrics, etc. When used as a wet tissue, toilet seat cleaner, or an antibacterial agent for fibers, all fibers such as cotton, polyester, acrylic, and nylon may be treated by a general method such as stirring, dipping or spraying. In addition, the antibacterial composition of the present invention can be applied or sprayed onto the surface of wood, daily necessities and the like. Furthermore, when used for synthetic resins, etc., it may be adhered to the surface by applying or spraying the antibacterial composition of the present invention after molding, or kneaded at the time of molding to maintain the antibacterial effect. You can also. Among these, since the antibacterial composition of the present invention is highly safe for the human body, it is preferably used for cosmetics and body cleaning agents that directly touch the human body, such as cosmetics and body wash used on the face. More preferably, it is used in the preparation.
　本発明の抗菌性組成物を好ましく使用できる化粧料としては、例えば、化粧料としては、例えば、シャンプー、ドライシャンプー、リンス一体型シャンプー、ヘアリンス、ヘアコンディショナー、ヘアパック、ヘアトリートメント、ヘアトニック、ポマード、チック、ヘアクリーム、ヘアワックス、ヘアジェル、ヘアフォーム、ヘアムース、ヘアミスト、ヘアローション、パーマネントウエーブ剤、染毛剤等のヘアケア化粧料；洗顔料、洗顔クリーム、洗顔フォーム、クレンジングクリーム、クレンジングフォーム、ハンドソープ、ボディソープ、ボディローション、サンスクリーン剤、化粧水、乳液、美容液、フェイスクリーム、コールドクリーム、フェイスパック、制汗剤、シェービングソープ、シェービングフォーム、シェービングオイル、シェービングローション、、アフターシェーブローション、アフターサンローション等のスキンケア化粧料；ファンデーション、コンシーラー、フェイスパウダー、ほほ紅、マスカラ、アイライナー、アイシャドウ等のメイクアップ化粧料；リップクリーム、入浴剤等が挙げられる。 As cosmetics that can preferably use the antibacterial composition of the present invention, for example, cosmetics include, for example, shampoo, dry shampoo, rinse-integrated shampoo, hair rinse, hair conditioner, hair pack, hair treatment, hair tonic, pomade. , Tics, hair creams, hair waxes, hair gels, hair foams, hair mousses, hair mists, hair lotions, permanent waving agents, hair dyes, etc .; facial cleansers, facial cleansing creams, facial cleansing foams, cleansing creams, cleansing foams, hands Soap, body soap, body lotion, sunscreen agent, lotion, milky lotion, serum, face cream, cold cream, face pack, antiperspirant, shaving soap, shaving foam, shaving Skin care cosmetics such as ir, shaving lotion, after shave lotion, after sun lotion; makeup cosmetics such as foundation, concealer, face powder, blusher, mascara, eyeliner, eye shadow; lip balm, bathing agent, etc. It is done.
　本発明の抗菌性組成物を含む化粧料は、化粧料に通常使用される界面活性剤を含んでもよい。このような界面活性剤としては、例えば、アニオン性界面活性剤、カチオン性界面活性剤、窒素不含ノニオン性界面活性剤等が挙げられる。 The cosmetic containing the antibacterial composition of the present invention may contain a surfactant usually used in cosmetics. Examples of such surfactants include anionic surfactants, cationic surfactants, nitrogen-free nonionic surfactants, and the like.
　アニオン性界面活性剤としては、例えば、高級脂肪酸塩、高級アルコール硫酸エステル塩、硫酸化オレフィン塩、高級アルキルスルホン酸塩、α－オレフィンスルホン酸塩、硫酸化脂肪酸塩、スルホン化脂肪酸塩、リン酸エステル塩、脂肪酸エステルの硫酸エステル塩、グリセライド硫酸エステル塩、脂肪酸エステルのスルホン酸塩、α－スルホ脂肪酸メチルエステル塩、ポリオキシアルキレンアルキルエーテル硫酸エステル塩、ポリオキシアルキレンアルキルフェニルエーテル硫酸エステル塩、ポリオキシアルキレンアルキルエーテルカルボン酸塩、アシル化ペプチド、脂肪酸アルカノールアミド又はそのアルキレンオキサイド付加物の硫酸エステル塩、スルホコハク酸エステルの塩、アルキルベンゼンスルホン酸塩、アルキルナフタレンスルホン酸塩、アルキルベンゾイミダゾールスルホン酸塩、ポリオキシアルキレンスルホコハク酸塩、Ｎ－アシル－Ｎ－メチルタウリンの塩、Ｎ－アシルグルタミン酸又はその塩、アシルオキシエタンスルホン酸塩、アルコキシエタンスルホン酸塩、Ｎ－アシル－β－アラニン又はその塩、Ｎ－アシル－Ｎ－カルボキシエチルタウリン又はその塩、Ｎ－アシル－Ｎ－カルボキシメチルグリシン又はその塩、アシル乳酸塩、Ｎ－アシルサルコシン塩、及びアルキル又はアルケニルアミノカルボキシメチル硫酸塩等が挙げられる。このようなアニオン性界面活性剤の塩の対イオンとしては、リチウム、ナトリウム、カリウム等のアルカリ金属イオン；カルシウム、マグネシウム等のアルカリ土類金属イオン；アンモニウム；モノエタノールアンモニウム、ジエタノールアンモニウム、トリエタノールアンモニウム、モノイソプロパノールアンモニウム、ジイソプロパノールアンモニウム、トリイソプロパノールアンモニウム等の有機アンモニウム等が挙げられる。 Examples of the anionic surfactant include higher fatty acid salts, higher alcohol sulfate esters, sulfated olefin salts, higher alkyl sulfonates, α-olefin sulfonates, sulfated fatty acid salts, sulfonated fatty acid salts, and phosphoric acid. Ester salt, sulfate ester of fatty acid ester, glyceride sulfate ester salt, sulfonate salt of fatty acid ester, α-sulfo fatty acid methyl ester salt, polyoxyalkylene alkyl ether sulfate ester, polyoxyalkylene alkyl phenyl ether sulfate ester, poly Oxyalkylene alkyl ether carboxylates, acylated peptides, fatty acid alkanolamides or sulfates of adducts thereof with alkylene oxide, salts of sulfosuccinic acid esters, alkylbenzene sulfonates, alkylnaphthalenes Sulfonate, alkyl benzimidazole sulfonate, polyoxyalkylene sulfosuccinate, N-acyl-N-methyltaurine salt, N-acyl glutamic acid or its salt, acyloxyethane sulfonate, alkoxyethane sulfonate, N -Acyl-β-alanine or its salt, N-acyl-N-carboxyethyltaurine or its salt, N-acyl-N-carboxymethylglycine or its salt, acyl lactate, N-acyl sarcosine salt, and alkyl or alkenyl Examples thereof include aminocarboxymethyl sulfate. Counter ions of such anionic surfactant salts include alkali metal ions such as lithium, sodium and potassium; alkaline earth metal ions such as calcium and magnesium; ammonium; monoethanolammonium, diethanolammonium and triethanolammonium And organic ammonium such as monoisopropanolammonium, diisopropanolammonium and triisopropanolammonium.
　カチオン性界面活性剤としては、例えば、アルキルジメチルアミン、アルケニルジメチルアミン、脂肪酸ジメチルアミノプロピルアミド、脂肪酸ジエチルアミノエチルアミド等のアミン系界面活性剤；アルキルトリメチルアンモニウム塩、アルケニルトリメチルアンモニウム塩、アルキルジエタノールアンモニウム塩、アルケニルジエタノールアンモニウム塩、アルキルジメチルベンジルアンモニウム塩、アルケニルジメチルベンジルアンモニウム塩、ジアルキルジメチルアンモニウム塩、アルキルジエタノールアンモニウム塩、アルキルピリジニウム塩、３－アルコキシ－２－ヒドロキシプロピルトリメチルアンモニウム塩、ポリオキシプロピレンメチルジエチルアンモニウム塩等のアンモニウム塩系界面活性剤が挙げられる。アンモニウム塩系界面活性剤の対イオンとしては、塩素イオン、臭素イオン等が挙げられる。 Examples of cationic surfactants include amine surfactants such as alkyldimethylamine, alkenyldimethylamine, fatty acid dimethylaminopropylamide, and fatty acid diethylaminoethylamide; alkyltrimethylammonium salts, alkenyltrimethylammonium salts, alkyldiethanolammonium salts Alkenyldiethanolammonium salt, alkyldimethylbenzylammonium salt, alkenyldimethylbenzylammonium salt, dialkyldimethylammonium salt, alkyldiethanolammonium salt, alkylpyridinium salt, 3-alkoxy-2-hydroxypropyltrimethylammonium salt, polyoxypropylenemethyldiethylammonium salt Examples thereof include ammonium salt surfactants such as salts. Examples of the counter ion of the ammonium salt surfactant include chlorine ion and bromine ion.
　窒素不含ノニオン性界面活性剤としては、例えば、ポリオキシアルキレンアルキルエーテル、ポリオキシアルキレンアルケニルエーテル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル（エチレンオキサイドとプロピレンオキサイドの付加形態は、ランダム状、ブロック状の何れでもよい）、ポリエチレングリコールプロピレンオキサイド付加物、ポリプロピレングリコールエチレンオキサイド付加物、グリセリン脂肪酸エステル又はそのエチレンオキサイド付加物、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、アルキルポリグルコシド、ショ糖脂肪酸エステル、アルキル（ポリ）グリセリンエーテル、ポリグリセリン脂肪酸エステル、ポリエチレングリコール脂肪酸エステル、脂肪酸メチルエステルエトキシレート等が挙げられる。 Examples of nitrogen-free nonionic surfactants include polyoxyalkylene alkyl ethers, polyoxyalkylene alkenyl ethers, polyoxyethylene polyoxypropylene alkyl ethers (addition forms of ethylene oxide and propylene oxide include random and block forms) Any), polyethylene glycol propylene oxide adduct, polypropylene glycol ethylene oxide adduct, glycerin fatty acid ester or ethylene oxide adduct thereof, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyl polyglucoside, sucrose fatty acid ester, alkyl (Poly) glycerin ether, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, fatty acid methyl Ester ethoxylates, and the like.
　本発明の抗菌性組成物を含む化粧料及び洗浄剤は、上述した界面活性剤成分以外にも、本発明の目的を損なわない範囲で他の成分、例えば、シリコーン油、増粘剤、油剤、粉体（顔料、色素、樹脂）、その他の抗菌剤、香料、保湿剤、生理活性成分、塩類、溶媒、酸化防止剤、キレート剤、パール化剤、中和剤、ｐＨ調整剤、酵素等の成分を適宜配合することができる。 Cosmetics and cleaning agents containing the antibacterial composition of the present invention, in addition to the surfactant component described above, other components, such as silicone oil, thickener, oil agent, as long as the object of the present invention is not impaired. Powders (pigments, dyes, resins), other antibacterial agents, fragrances, moisturizers, physiologically active ingredients, salts, solvents, antioxidants, chelating agents, pearlizing agents, neutralizing agents, pH adjusters, enzymes, etc. Components can be appropriately blended.
　増粘剤としては、例えば、塩化ジメチルジアリルアンモニウム・アクリルアミド共重合体、アクリルアミド・アクリル酸・塩化ジメチルジアリルアンモニウム共重合体、セルロース又はその誘導体、ケラチン及びコラーゲン又はそれらの誘導体、アルギン酸カルシウム、プルラン、寒天、ゼラチン、タマリンド種子多糖類、キサンタンガム、カラギーナン、ハイメトキシルペクチン、ローメトキシルペクチン、グアーガム、アラビアゴム、結晶セルロース、アラビノガラクタン、カラヤガム、トラガカントガム、アルギン酸、アルブミン、カゼイン、カードラン、β－グルカン、ジェランガム、デキストラン等が挙げられる。 Examples of the thickener include dimethyldiallylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer, cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar , Gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabinogalactan, caraya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, β-glucan, gellan gum And dextran.
　油剤は、通常化粧料に用いられる揮発性及び不揮発性の炭化水素、高級アルコール、中鎖～高鎖脂肪酸及びそのエステル、油脂等が挙げられ、常温で液体、ペースト、固体であっても構わないが、ハンドリングに優れる液体が好ましい。油剤としては、例えば、セチルアルコール、イソステアリルアルコール、ラウリルアルコール、ヘキサデシルアルコール、オクチルドデカノール等の高級アルコール、イソステアリン酸、ウンデシレン酸、オレイン酸等の脂肪酸、ミリスチン酸ミリスチル、ラウリン酸ヘキシル、オレイン酸デシル、ミリスチン酸イソプロピル、ジメチルオクタン酸へキシルデシル、モノステアリン酸グリセリン、フタル酸ジエチル、モノステアリン酸エチレングリコール、オキシステアリン酸オクチル等のエステル類、流動パラフィン、ワセリン、スクワラン等の炭化水素、ラノリン、還元ラノリン、カルナバロウ等のロウ、ミンク油、カカオ脂、ヤシ油、パーム核油、ツバキ油、ゴマ油、ヒマシ油、オリーブ油等の油脂等が挙げられる。 Examples of the oil include volatile and nonvolatile hydrocarbons usually used in cosmetics, higher alcohols, medium to high chain fatty acids and esters thereof, fats and oils, and may be liquid, paste, or solid at room temperature. However, a liquid excellent in handling is preferable. Examples of the oil agent include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol and octyldodecanol, fatty acids such as isostearic acid, undecylenic acid and oleic acid, myristyl myristate, hexyl laurate, and oleic acid. Decyl, isopropyl myristate, hexyldecyl dimethyloctanoate, glyceryl monostearate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, hydrocarbons such as liquid paraffin, petrolatum, squalane, lanolin, reduction Examples include waxes such as lanolin and carnauba wax, oils and fats such as mink oil, cacao butter, coconut oil, palm kernel oil, camellia oil, sesame oil, castor oil and olive oil.
　粉体としては、例えば、赤色２０１号、黄色４号、青色１号、黒色４０１号等の色素、黄色４号Ａｌレーキ、黄色２０３号Ｂａレーキ等のレーキ色素、ナイロンパウダー、シルクパウダー、シリコーンパウダー、セルロースパウダー、シリコーンエラストマー球状粉体、ポリエチレン末等の高分子、黄酸化鉄、赤色酸化鉄、酸化クロム、カーボンブラック、群青、紺青等の有色顔料、酸化亜鉛、酸化チタン等の白色顔料、タルク、マイカ、セリサイト、カオリン等の体質顔料、雲母チタン等のパール顔料、硫酸バリウム、炭酸カルシウム、炭酸マグネシウム、珪酸マグネシウム等の金属塩、シリカ、アルミナ等の無機粉体、ベントナイト、スメクタイト、窒化ホウ素等が挙げられる。これらの粉体の形状（球状、棒状、針状、板状、不定形状、燐片状、紡錘状等）に特に制限はない。 Examples of the powder include pigments such as red No. 201, yellow No. 4, blue No. 1, black No. 401, lake pigments such as yellow No. 4 Al lake, yellow No. 203 Ba lake, nylon powder, silk powder, and silicone powder. , Cellulose powder, silicone elastomer spherical powder, polymers such as polyethylene powder, yellow iron oxide, red iron oxide, chromium oxide, carbon black, colored pigments such as ultramarine and bitumen, white pigments such as zinc oxide and titanium oxide, talc Body pigments such as mica, sericite, kaolin, pearl pigments such as titanium mica, metal salts such as barium sulfate, calcium carbonate, magnesium carbonate, magnesium silicate, inorganic powders such as silica and alumina, bentonite, smectite, boron nitride Etc. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, indeterminate, flake-like, spindle-like, etc.).
　これらの粉体は、従来公知の表面処理、例えばフッ素化合物処理、シリコーン処理、シリコーン樹脂処理、ペンダント処理、シランカップリング剤処理、チタンカップリング剤処理、油剤処理、Ｎ－アシル化リジン処理、ポリアクリル酸処理、金属石鹸処理、アミノ酸処理、無機化合物処理、プラズマ処理、メカノケミカル処理等によって事前に表面処理されていても構わない。 These powders are treated with conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, Surface treatment may be performed in advance by acrylic acid treatment, metal soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, or the like.
　その他の抗菌剤としては、例えば、メチルパラベン、エチルパラベン等のパラベン系抗菌剤；チアベンダゾール、２－ベンツイミダゾリルカルバミン酸メチル、イミダゾリジニルウレアのイミダゾール系抗菌剤；トリクロロカルバニリド、クロフルカルバン等のカーバニリド系抗菌剤；ベンゾチアゾール等のチアゾール系抗菌剤；デブコナゾール、カビノン等のトリアジン系抗菌剤；クロルヘキシジン塩酸塩、ポリヘキサメチレンビグアナイド等のビグアナイド系抗菌剤等が挙げられるが、これらの抗菌剤を併用する場合には、人体に対する刺激性等を考慮して慎重に使用すべきである。 Other antibacterial agents include, for example, paraben antibacterial agents such as methyl paraben and ethyl paraben; imidazole antibacterial agents such as thiabendazole, methyl 2-benzimidazolylcarbamate and imidazolidinyl urea; trichlorocarbanilide, cloflucarban, etc. Carbanilide antibacterial agents; thiazole antibacterial agents such as benzothiazole; triazine antibacterial agents such as debuconazole and kabinone; biguanide antibacterial agents such as chlorhexidine hydrochloride and polyhexamethylene biguanide, etc. When doing so, it should be used with caution in consideration of irritation to the human body.
　保湿剤としては、例えば、ジエチレングリコールモノエチルエーテル、デオキシリボ核酸、ムコ多糖類、ヒアルロン酸ナトリウム、コンドロイチン硫酸ナトリウム、コラーゲン、エラスチン、キチン、キトサン、加水分解卵殻膜等の生体高分子、アミノ酸、乳酸ナトリウム、尿素、ピロリドンカルボン酸ナトリウム、ベタイン、ホエイ等が挙げられる。 Examples of humectants include biopolymers such as diethylene glycol monoethyl ether, deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, sodium lactate, Examples include urea, sodium pyrrolidonecarboxylate, betaine, and whey.
　溶媒としては、例えば、精製水、エタノール、軽質流動イソパラフィン、低級アルコール、エーテル類、ＬＰＧ、フルオロカーボン、Ｎ－メチルピロリドン、フルオロアルコール、次世代フロン等が挙げられる。 Examples of the solvent include purified water, ethanol, light liquid isoparaffin, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, and next-generation chlorofluorocarbon.
　以下、本発明を実施例により、具体的に説明する。尚、以下の実施例等において「％」及び「ｐｐｍ」は特に記載が無い限り質量基準である。 Hereinafter, the present invention will be specifically described by way of examples. In the following examples and the like, “%” and “ppm” are based on mass unless otherwise specified.
＜実験に使用した化合物＞
（Ａ）成分
Ａ１：１，２－ペンタンジオール
Ａ２：１，２－ヘキサンジオール
Ａ３：１，２－オクタンジオール
Ａ４：１，２－デカンジオール
（Ｂ）成分
Ｂ：ベンジルオキシエタノール <Compounds used in the experiment>
(A) Component A1: 1,2-pentanediol A2: 1,2-hexanediol A3: 1,2-octanediol A4: 1,2-decanediol (B) Component B: benzyloxyethanol
（Ｃ）成分
Ｃ１：グルタミン酸ジ酢酸４Ｎａ
Ｃ２：グリセリン
Ｃ３：ヤシ脂肪酸モノエタノールアミド（コカミドＭＥＡ）
（Ｄ）成分
Ｄ１：フェノキシエタノール
Ｄ２：メチルパラベン
Ｄ３：カプリル酸グリセリル (C) Component C1: Glutamic acid diacetate 4Na
C2: Glycerin C3: Palm fatty acid monoethanolamide (cocamide MEA)
(D) Component D1: Phenoxyethanol D2: Methyl paraben D3: Glyceryl caprylate
　上記の化合物を用いて、表１に示す組成を有する実施例１～１０及び表２に示す比較例１～１８の抗菌剤を調製した。なお表１及び表２中の数字は質量％である。 Using the above compounds, antibacterial agents of Examples 1 to 10 and Comparative Examples 1 to 18 shown in Table 2 having the compositions shown in Table 1 were prepared. The numbers in Tables 1 and 2 are mass%.
＜実験に使用した菌＞
B.cep：Burkholderia cepacia（細菌）
P.aer：Pseudomonas aeruginosa（細菌）
A.bra：Aspergillus brasiliensis（真菌） <Bacteria used in the experiment>
B.cep: Burkholderia cepacia (bacteria)
P.aer: Pseudomonas aeruginosa (bacteria)
A.bra: Aspergillus brasiliensis (fungus)
Figure JPOXMLDOC01-appb-T000017
Figure JPOXMLDOC01-appb-T000017
Figure JPOXMLDOC01-appb-T000018
Figure JPOXMLDOC01-appb-T000018
　下記の配合で、処方１と処方２を調整した。抗菌剤の配合量が０．４質量％と０．８質量％の２種類あるが、配合量が０．４質量％のものは、B.cep及びP.aerに対する試験で、配合量が０．８質量％のものは、A.braに対する試験で用いた。なお、処方１はスキンクリーム処方、処方２はコンディショナー処方であり乳化系はいずれもＯ／Ｗエマルションである。 Formula 1 and Formula 2 were adjusted with the following composition. There are two types of antibacterial agents, 0.4% by mass and 0.8% by mass, but those with a compounding amount of 0.4% by mass are tested for B.cep and P.aer and the amount is 0 8% by weight was used in the test against A.bra. Formula 1 is a skin cream formula, Formula 2 is a conditioner formula, and both emulsion systems are O / W emulsions.
＜処方１：スキンクリーム＞
トリエチルヘキサノイン　　２０質量％
テトラオレイン酸ソルベス－３０　　４質量％
セテアリルアルコール　　０．２質量％
グリセリン　　０．２質量％
（アクリレーツ／アクリル酸アルキル（Ｃ１０－３０））クロスポリマー　　０．１質量％
抗菌剤　　０．４質量％又は０．８質量％
水酸化ナトリウム　　適量(pH6.0に調整)
水　　残部 <Formulation 1: Skin cream>
Triethylhexanoin 20% by mass
4% by weight of sorbes tetraoleate-30
Cetearyl alcohol 0.2% by mass
Glycerin 0.2% by mass
(Acrylates / alkyl acrylate (C10-30)) Crosspolymer 0.1% by mass
Antibacterial agent 0.4% by mass or 0.8% by mass
Sodium hydroxide appropriate amount (adjusted to pH 6.0)
Water balance
＜処方２：ヘアコンディショナー＞
ステアリルアルコール　　１．０質量％
ベヘントリモニウムクロリド　　０．５質量％
セタノール　　０．５質量％
アモジメチコン　　０．５質量％
抗菌剤　　０．４質量％又は０．８質量％
水　　残部 <Formulation 2: Hair conditioner>
Stearyl alcohol 1.0 mass%
Behentrimonium chloride 0.5% by mass
Cetanol 0.5% by mass
Amodimethicone 0.5% by mass
Antibacterial agent 0.4% by mass or 0.8% by mass
Water balance
　滅菌済み３０ｍＬの蓋付ガラス瓶に２０ｇの処方１又は処方２の製剤と、菌の濃度が１．０×１０8ｃｆｕ／ｍＬの菌液を０．２ｍＬいれ、均一に混合する。ガラス瓶を２５℃の恒温槽に保存し、B.cep及びP.aerは２日後、及び７日後、A.braは７日後、及び２８日後にサンプリングして、生菌数の濃度（単位：ｃｆｕ／ｍＬ）を測定し、以下の式により抗菌活性値を求めた。抗菌活性値の値が大きいほど、抗菌性が高いことを示す。処方１を用いた結果を表３及び４、処方２を用いた結果を表５及び６に示す。
　抗菌活性値＝６－Ｌｏｇ（生菌数の濃度（ｃｆｕ／ｍＬ）） Into a sterile 30 mL glass bottle with a lid, add 20 g of the preparation of Formula 1 or 2 and 0.2 mL of a bacterial solution having a concentration of bacteria of 1.0 × 10 8 cfu / mL, and mix them uniformly. The glass bottle is stored in a thermostatic bath at 25 ° C., B.cep and P.aer are sampled after 2 days and 7 days, A.bra is sampled after 7 days and 28 days, and the concentration of viable bacteria is measured (unit: cfu). / ML) was measured, and the antibacterial activity value was determined by the following formula. It shows that antimicrobial property is so high that the value of an antimicrobial activity value is large. The results using Formula 1 are shown in Tables 3 and 4, and the results using Formula 2 are shown in Tables 5 and 6.
Antibacterial activity value = 6-Log (concentration of viable count (cfu / mL))
Figure JPOXMLDOC01-appb-T000019
Figure JPOXMLDOC01-appb-T000019
Figure JPOXMLDOC01-appb-T000020
Figure JPOXMLDOC01-appb-T000020
Figure JPOXMLDOC01-appb-T000021
Figure JPOXMLDOC01-appb-T000021
Figure JPOXMLDOC01-appb-T000022
Figure JPOXMLDOC01-appb-T000022
　Ａ１、Ａ２、Ａ４及びＢ１を単独で用いた場合は、処方１、２ではほとんど抗菌性が見られなかった。Ａ３を単独で用いた場合は、細菌（B.cep、P.aer）に対して、抗菌性が見られるが、真菌（A.bra）への抗菌性は見られなかった。（Ａ）成分と（Ｂ）成分を併用した本発明の抗菌組成物はいずれも細菌だけではなく、真菌に対しても高い抗菌性が見られ、（Ａ）成分と（Ｂ）成分に相乗効果があることが分かる。また（Ｃ）成分を配合することにより、さらに、抗菌性の向上がみられた。 When A1, A2, A4 and B1 were used alone, antibacterial properties were hardly seen in Formulations 1 and 2. When A3 was used alone, antibacterial activity was observed against bacteria (B. cep, P. aer), but antibacterial activity against fungi (A. bra) was not observed. The antibacterial composition of the present invention using both the component (A) and the component (B) exhibits high antibacterial properties not only against bacteria but also against fungi, and a synergistic effect between the components (A) and (B). I understand that there is. Moreover, antibacterial improvement was seen by mix | blending (C) component.

Claims (6)

  1. 　（Ａ）成分として下記の一般式（１）で表わされるジオール化合物、及び（Ｂ）成分としてベンジルオキシエタノールを含有する抗菌性組成物。
    Figure JPOXMLDOC01-appb-C000001
     （式中、Ｒ1は炭素数３～８のアルキル基を表わす。）     An antibacterial composition containing a diol compound represented by the following general formula (1) as the component (A) and benzyloxyethanol as the component (B).
    Figure JPOXMLDOC01-appb-C000001
     (In the formula, R 1 represents an alkyl group having 3 to 8 carbon atoms.)
  2. 　（Ａ）成分と（Ｂ）成分の質量比が１０：９０～９０：１０である請求項１に記載の抗菌性組成物。 The antibacterial composition according to claim 1, wherein the mass ratio of the component (A) to the component (B) is 10:90 to 90:10.
  3. 　更に、（Ｃ）成分として、キレート剤、低分子ポリオール（但し、（Ａ）成分に該当するジオール化合物は除く）、窒素含有ノニオン界面活性剤、窒素含有両性界面活性剤、植物由来エキス及び亜鉛化合物からなる群から選択される１種又は２種以上の成分を含有する、請求項１又は２に記載の抗菌性組成物。 Furthermore, as the component (C), a chelating agent, a low molecular polyol (excluding the diol compound corresponding to the component (A)), a nitrogen-containing nonionic surfactant, a nitrogen-containing amphoteric surfactant, a plant-derived extract, and a zinc compound The antimicrobial composition of Claim 1 or 2 containing the 1 type, or 2 or more types of component selected from the group which consists of.
  4. 　化粧料の防腐に使用される、請求項１～３のいずれか１項に記載の抗菌性組成物。 The antibacterial composition according to any one of claims 1 to 3, which is used for preserving cosmetics.
  5. 　請求項１～４のいずれか１項に記載の抗菌性組成物を含有する化粧料。 Cosmetics containing the antibacterial composition according to any one of claims 1 to 4.
  6. 　化粧料に、下記の一般式（１）で表わされるジオール化合物（（Ａ）成分）、及びベンジルオキシエタノール（（Ｂ）成分）を添加することを含む、化粧料に抗菌性を付与する方法。
    Figure JPOXMLDOC01-appb-C000002
     （式中、Ｒ1は炭素数３～８のアルキル基を表わす。）     A method for imparting antibacterial properties to a cosmetic, comprising adding a diol compound (component (A)) represented by the following general formula (1) and benzyloxyethanol (component (B)) to the cosmetic.
    Figure JPOXMLDOC01-appb-C000002
     (In the formula, R 1 represents an alkyl group having 3 to 8 carbon atoms.)
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