JP2017025050A - Sheet-like product for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a sheet-like product for skin which suppresses irritation to the skin even when a stimulant component is contained, has a smooth and silky feeling of use, and has an excellent moisturizing effect even after use.SOLUTION: The problem can be solved by incorporating the following components (I) and (II) into a sheet-like product for skin. (I) One or two or more members selected from the group consisting of low molecular weight polyols and higher alcohols (excluding β-1,3-1,6-glucan), (II) β-1,3-1,6-glucan.SELECTED DRAWING: None

Description

  The present invention relates to a sheet-like product for skin that suppresses irritation to the skin even when an irritating component is contained, has a smooth and smooth feeling of use, and has an excellent moisturizing effect even after use. .

  Skin-like products made by impregnating sheets of pulp and synthetic fibers with water, preservatives, moisturizers, cleaning agents, etc. can be easily wiped off anywhere, and many are disposable after use. Since this process is simple, it is used in various situations. For example, various uses such as wipes for wipes, makeup wipes, wipes for body washing, lotion tissue, and wiping wipes for infants and the like, sheet materials and chemicals suitable for each use have been developed.

Among these, as a study on the chemical solution, various studies have been conducted on methods for suppressing skin irritation by the chemical solution and suppressing rough skin.
For example, a wet tissue in which a chemical solution containing 0.01 to 3.00% by mass of ε-polylysine or a salt thereof and 0.01 to 3.00% by mass of an alkali metal salt of sorbic acid is applied to a nonwoven fabric (Patent Documents) 1) Wet tissue in which paper, woven fabric or non-woven fabric is wetted by applying, spraying or impregnating an aqueous solution containing hinokitiol or a metal complex thereof or a salt thereof or an alcohol solution having an alcohol content of 10 to 60% (Patent Document) 2), (A) ε-polylysine and / or a salt thereof, (AB) an electrolyte having pH buffering ability, and (C) an antibacterial composition containing amino acids (Patent Document 3) is disclosed.

However, sufficient bactericidal effects and the like cannot often be obtained with only a low irritation component, and there has been a demand for a method for suppressing damage to the skin even when an irritation component is used.
On the other hand, the “feeling of use” when using a skin-like product depends largely on the sheet material, and the chemical solution is not sufficiently studied. In particular, when a sheet material having a strong roughness is used, the skin surface may be physically damaged or excessively deprived of moisture, and improvement in the feeling of use with a chemical solution has been demanded.

JP 2003-339567 A JP 2009-268698 A JP 2004-67586 A

  Accordingly, the object of the present invention is to provide a skin sheet that suppresses irritation to the skin even when an irritating component is contained, has a smooth and smooth feeling of use, and has an excellent moisturizing effect even after use. Is to provide a product.

  As a result of various studies to solve the above problems, the present inventors have found that the above problems can be solved when a low molecular polyol or higher alcohol is used in combination with β-1,3-1,6-glucan.

  According to the present invention, even when an irritating component is contained, the skin sheet is suppressed to irritation to the skin, has a smooth and smooth feeling of use, and has an excellent moisturizing effect even after use. You can get a product.

Hereinafter, the sheet-like product for skin of the present invention will be described in detail.
The sheet product for skin of the present invention contains the following components (I) and (II).
(I) One or more selected from the group consisting of low molecular polyols and higher alcohols (excluding β-1,3-1,6-glucan)
(II) β-1,3-1,6-glucan

First, the low molecular polyol which is one of the essential components (I) of the present invention will be described.
In the present invention, the low molecular polyol refers to a polyol having a molecular weight of 50 to 1000, preferably 50 to 500.

  For example, ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 1,4 -Butanediol, 2,3-butanediol, 2-methyl-1,2-propanediol, 2-methyl-1,3-propanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4 -Pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2-methyl-1,2-butanediol, 2-methyl-2,3-butanediol, 2-methyl -1,4-butanediol, 3-methyl-1,2-butanedio 3-methyl-1,3-butanediol, 2-ethyl-1,3-propanediol, 2,2-dimethyl-1,3-propanediol, 1,2-hexanediol, 1,5-hexanediol, , 6-hexanediol, 2,5-hexanediol, 3,3-hexanediol, 2-methyl-1,3-pentanediol, 2-methyl-1,5-pentanediol, 2-methyl-2,4- Pentanediol, 3-methyl-1,5-pentanediol, 3-methyl-2,3-pentanediol, 3-methyl-2,4-pentanediol, 4-methyl-1,2-pentanediol, 2-ethyl -2-methyl-1,3-propanediol, 2,2-dimethyl-1,3-butanediol, 2,3-dimethyl-1,2-butanediol, 1,2-heptane All, 1,7-heptanediol, 3,4-heptanediol, 2-propyl-2-methyl-1,3-propanediol, 2-isopropyl-2-methyl-1,3-propanediol, 1,2- Octanediol, 1,8-octanediol, 3,6-octanediol, 2-ethyl-1,3-hexanediol, 2-sec-butyl-2-butyl-1,3-propanediol, 2,2-dimethyl -1,3-hexanediol, 2,5-dimethyl-2,5-hexanediol, 2,2,4-trimethyl-1,3-pentanediol, 1,2-nonanediol, 1,3-nonanediol, 1,9-nonanediol, 3,6-octanediol, 2-ethyl-2- (2-methyl) propyl-1,3-propanediol, 2,2,4-trimethyl -1,6-hexanediol, 2,4,4-trimethyl-1,6-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 2,4-diethyl-1,5-pentanediol 2-methyl-1,8-octanediol, 1,2-decanediol, 1,10-decanediol, 5,6-decanediol, 3,6-dimethyl-3,6-octanediol, 3,7- Dimethyl-1,6-octanediol, 3,7-dimethyl-1,7-octanediol, 1,2-undecanediol, 1,4-undecanediol, 1,11-undecanediol, 6-ethyl-3-methyl -1,6-octanediol, 1,2-dodecanediol, 1,10-dodecanediol, 1,12-dodecanediol, 2,4-diethyl-1,5-octa Diol, 2,8,8-trimethyl-2,7-nonanediol, 1,2-tetradecanediol, 1,14-tetradecanediol, 7,8-tetradecanediol, 1,2-pentadecanediol, 1,2-hexadecane Diol, 1,16-hexadecanediol, 1,17-heptadecanediol, 1,2-octadecanediol, 1,12-octadecanediol, 1,2-eicosanediol, 1,2-docosanediol, 1,2 -Saturated diols such as tetracosanediol, hexylglycerin, cyclohexylglycerin, ethylhexylglycerin or condensates thereof;

2-butene-1,4-diol, 3-butene-1,2-diol, 2-methylene-1,3-propanediol, 2-butyne-1,4-diol, 5-hexene-1,2-diol 3-methyl-2-pentene-1,5-diol, 3-methylenepentane-1,5-diol, 1,5-hexadiene-3,4-diol, 7-octene-1,2-diol, 2, 5-dimethyl-3-hexene-2,5-diol, 9-decene-1,2-diol, 2,6-dimethyl-7-octene-2,6-diol, 3,7-dimethyl-7-octene- 1,6-diol, 13-tetradecene-1, 2-diol, 12-hydroxy-9-octadecenol, 2-pentyne-1,4-diol, 3-hexyne-2,5-diol, 4-methyl-2- Pentin , 4-diol, 3-heptin-2,5-diol, 4-methyl-2-pentyne-1,4-diol, 3,4-dimethyl-1-pentyne-3,4-diol, 2,5-dimethyl -3-hexyne-2,5-diol, 5-decyne-4,7-diol, 2,6-dimethyl-7-octyne-2,6-diol, 3,6-dimethyl-4-octyne-3,6 -Diol, 2,3,6,7-tetramethyl-4-octyne-3,6-diol, 2,4,7,9-tetramethyl-5-decyne-4,7-diol, 2,5,8 , 11-tetramethyl-6-dodecin-5,8-diol, 1,1,4,4-tetraisopropyl-4-octyne-3,6-diol, 5,10-diethyl-7-tetradecine-6,9 -Unsaturated diols such as diols;

1,2-cyclopentanediol, 1,3-cyclopentanediol, 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2-cycloheptanediol, 2,3-norbornane Diol, 2,5-norbornanediol, 2,7-norbornanediol, 1,2-cyclooctanediol, 1,4-cyclooctanediol, 1,2-cyclodecanediol, 5-cyclooctene-1,2-diol Alicyclic diols such as 1,5-decalindiol, limonene glycol, 1,2-terpenediol, 4,4′-bicyclohexanediol, 1,2-cyclododecanediol;

Glycerin, 1,2,3-butanetriol, 1,2,4-butanetriol, 2-methyl-1,2,3-propanetriol, 1,2,3-pentanetriol, 1,2,4-pentanetriol 1,3,5-pentanetriol, 2,3,4-pentanetriol, 2-methyl-2,3,4-butanetriol, trimethylolethane, 2,3,4-hexanetriol, 2-ethyl-1 , 2,3-butanetriol, trimethylolpropane, 4-propyl-3,4,5-heptanetriol, 2,4-dimethyl-2,3,4-pentanetriol, triethanolamine, triisopropanolamine, etc. Alcohols;

Erythritol, pentaerythritol, 1,2,3,4-pentatetrol, 2,3,4,5-hexatetrol, 1,2,4,5-pentanetetrol, 1,3,4,5-hexane Tetrahydric alcohols such as tetrol, diglycerin, sorbitan, N, N, N ′, N′-tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N ′, N′-tetrakis (hydroxyethyl) ethylenediamine;

Pentavalent alcohols such as adonitol, arabitol, xylitol, triglycerin; hexavalent alcohols such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, dulcitol, talose, allose;

1-methyl glyceryl ether, 2-methyl glyceryl ether, 1-ethyl glyceryl ether, 2-ethyl glyceryl ether, 1-propyl glyceryl ether, 2-propyl glyceryl ether, 1-isopropyl glyceryl ether, 2-isopropyl glyceryl ether, 1- Butyl glyceryl ether, 2-butyl glyceryl ether, 1-isobutyl glyceryl ether, 2-isobutyl glyceryl ether, 1-pentyl glyceryl ether, 2-pentyl glyceryl ether, 1-hexyl glyceryl ether, 2-hexyl glyceryl ether, 1-heptyl glyceryl Ether, 2-heptyl glyceryl ether, 1-octyl glyceryl ether, 2-octyl glyceryl ether, 1- (2-ethylhexyl) Lyceryl ether, 2- (2-ethylhexyl) glyceryl ether, 1-nonyl glyceryl ether, 2-nonyl glyceryl ether, 1-decyl glyceryl ether, 2-decyl glyceryl ether, 1-undecyl glyceryl ether, 2-undecyl glyceryl Ether, 1-dodecyl glyceryl ether, 2-dodecyl glyceryl ether, 1-tridecyl glyceryl ether, 2-tridecyl glyceryl ether, 1-tetradecyl glyceryl ether, 2-tetradecyl glyceryl ether, 1-hexadecyl glyceryl ether, 2 -Hexadecyl glyceryl ether, 1-octadecyl glyceryl ether, 2-octadecyl glyceryl ether, 1-branched octadecyl glyceryl ether, 2-branched octadecyl glycerin Ryl ether, 1-eicosyl glyceryl ether, 2-eicosyl glyceryl ether, 1-allyl glyceryl ether, 2-allyl glyceryl ether, 1-undecenyl glyceryl ether, 2-undecenyl glyceryl ether, 1-oleyl glyceryl ether, Glycerin monoethers such as 2-oleyl glyceryl ether, 1-phenyl glyceryl ether, 2-phenyl glyceryl ether;

N-substituted diethanolamines such as N-methyldiethanolamine, N-ethyldiethanolamine, N-propyldiethanolamine, N-isopropyldiethanolamine, N-butyldiethanolamine, N-cyclohexyldiethanolamine, N- (2-ethylhexyl) diethanolamine;

N-methyldiisopropanolamine, N-ethyldiisopropanolamine, N-propyldiisopropanolamine, N-isopropyldiisopropanolamine, N-butyldiisopropanolamine, N-cyclohexyldiisopropanolamine, N- (2-ethylhexyl) di N-substituted diisopropanolamines such as isopropanolamine;

3-dimethylamino-1,2-propanediol, 3-diethylamino-1,2-propanediol, 3-dipropylamino-1,2-propanediol, 3-diisopropylamino-1,2-propanediol, 3- Examples include N, N-disubstituted-3-amino-1,2-propanediols such as dibutylamino-1,2-propanediol.

  Among these low molecular polyols, propylene glycol, dipropylene glycol, tripropylene glycol, 1,2-butanediol, 1,3-butanediol, 2,3-butanediol, 1,2-pentanediol, 3-methyl 1,3-butanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 2-ethyl-1,3-hexanediol, 1,2-nonanediol, 2-butyl- 2-ethyl-1,3-propanediol, 1,2-decanediol, 1,10-decanediol, hexylglycerol, cyclohexylglycerol, ethylhexylglycerol, glycerol, triethanolamine, triisopropanolamine, erythritol, diglycerol, sorbitan , N, N, N ′, N′-tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N ′, N′-tetrakis (hydroxyethyl) ethylenediamine, sorbitol, 1-methylglyceryl ether, 1-ethylglyceryl ether, 1-propylglyceryl ether, 1 -Butyl glyceryl ether, 1-octyl glyceryl ether, 1- (2-ethylhexyl) glyceryl ether, 1-decyl glyceryl ether, 1-allyl glyceryl ether are preferred, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3- Butanediol, 3-methyl-1,3-butanediol, 1,2-octanediol, hexylglycerol, cyclohexylglycerol, ethylhexylglycerol, glycerol, triethanolamine , Diglycerin, sorbitan, N, N, N ′, N′-tetrakis (2-hydroxypropyl) ethylenediamine, sorbitol, 1-allylglyceryl ether are more preferable, propylene glycol, dipropylene glycol, 1,3-butanediol, 3-methyl-1,3-butanediol, hexylglycerin, cyclohexylglycerin, ethylhexylglycerin, glycerin, sorbitol, and 1-allylglyceryl ether are more preferable.

Next, higher alcohols which are one of the essential components (I) of the present invention will be described.
Examples of higher alcohols that can be used in the present invention include linear alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, hardened rapeseed oil alcohol); For example, branched-chain alcohols (eg monostearyl glycerin ether (batyl alcohol), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol), etc. What is used can be used.

  In the present invention, the component (I) contains one or more selected from the group consisting of the above low molecular polyols and higher alcohols, and preferably a sheet material 100 used for a sheet product for skin described later. It is 0.001-50 mass parts with respect to a mass part, More preferably, it is 0.01-25 mass parts, More preferably, it is 0.1-20 mass parts, Most preferably, it is 0.5-10 mass parts. In addition, even when β-1,3-1,6-glucan, which is component (II) described later, also corresponds to component (I), β-1,3-1,6-glucan is a component. (I) shall not be counted.

Next, β-1,3-1,6-glucan, which is the essential component (II) of the present invention, will be described.
Β-glucose in which glucose is linked by β-1,3-glycoside bond and β-1,6-glycoside bond is called β-1,3-1,6-glucan, and (1) the main chain is β-1 , 3-glycosidic bonds and having a β-1,6-glycoside bond branch, (2) the main chain consisting of β-1,3-glycoside bonds and β-1,6-glycoside bonds, etc. It has been known. In addition, as β-1,3-1,6-glucan used in the present invention, those having a bond such as β-1,4-glycoside bond in part can also be used. The content of glucoside bonds other than bonds and β-1,6-glycoside bonds must be 10 mol% or less with respect to the total of β-1,3-glycoside bonds and β-1,6-glycoside bonds.

  Any β-1,3-1,6-glucan can be used as the β-1,3-1,6-glucan in the sheet-like product of the present invention, but the solubility is good. For this reason, β-1,3-1,6-glucan represented by the following general formula (1) is preferable:

  In the general formula (1), a represents a number of at least 20, and b represents a number of at least 1. However, the total number of a and b is a number which makes the mass average molecular weight of (beta) -1,3-1,6-glucan represented by General formula (1) 3000 to 5 million. When the mass average molecular weight of β-1,3-1,6-glucan represented by the general formula (1) is less than 3000 or more than 5 million, a sufficient moisturizing effect on the skin may not be obtained. is there. The mass average molecular weight of β-1,3-1,6-glucan represented by the general formula (1) is preferably 5,000 to 3,000,000, more preferably 7,000 to 1,000,000, and most preferably 10,000 to 500,000. In the present invention, the mass average molecular weight of β-1,3-1,6-glucan is a pullulan conversion when gel permeation chromatography (also referred to as GPC) analysis is performed using water as a solvent. It refers to the weight average molecular weight. The “mass average molecular weight” may be referred to as “weight average molecular weight”.

  The method for measuring the mass average molecular weight is not particularly limited, but as an example, using several pullulan species with known molecular weights (concentration is arbitrary), a calibration curve (with x-axis holding time, Create a molecular weight on the y-axis). Next, it is common to measure a sample (concentration is arbitrary) and calculate the relative molecular weight (molecular weight in terms of pullulan) from the retention time using the calibration curve.

  However, because pullulan and β-1,3-1,6-glucan have different molecular sizes due to structural differences even with the same molecular weight (the same number of glucose units), gel shake chromatography, which is a molecular sieve, can only obtain relative values. However, it is possible to calculate the intrinsic molecular weight approximated to the absolute value by correcting. Examples of the correction include a method of measuring the concentration of the specimen and measuring and calculating three points of differential pressure viscosity, differential refraction, and light scattering. Specifically, first, the apparatus constant k is obtained using a pullulan standard solution whose concentration, viscosity and refractive index are known.

  Next, the drug substance in which the concentration of β-1,3-1,6-glucan is measured by the phenol sulfuric acid method is accurately measured, and an aqueous solution with a known concentration is prepared as a specimen. Then, the molecular weight is calculated from the values measured by the differential pressure viscosity detector, the suggestive refraction detector, and the light scattering detector.

  In the general formula (1), the ratio of b to a is preferably 0.2 to 1 in terms of suppressing stickiness and imparting a better and smoother feeling when used. 0.95 is more preferable, and 0.6 to 0.9 is most preferable. The unit with the repetition number a and the unit with the repetition number b may be combined in a random manner or in a block shape.

  Β-1,3-1,6-glucan represented by the general formula (1) is a known method, for example, algae such as yeast, lactic acid bacteria, natto bacteria, acetic acid bacteria, koji molds, chlorella and spirulina, filamentous fungi, etc. In particular, β-1,3-1,6-glucan having a high moisturizing effect on the skin can be extracted from black yeast (Aureobasidiumu pullulans). The extraction method for β-1,3-1,6-glucan is not particularly limited, and may be a known method.

  Further, when the extracted β-1,3-1,6-glucan is concentrated, it is not particularly limited as long as it is a method for removing water or pulverizing, for example, spray drying, freeze drying, vacuum drying, and the like. , Heat drying, precipitation recovery with a solvent, and the like, and a combination thereof may be used.

  In the present invention, β-1,3-1,6-glucan is contained as component (II), and preferably 0.001 to 50 parts by weight with respect to 100 parts by weight of a sheet material used for a sheet product for skin described later. Parts by mass, more preferably 0.01 to 25 parts by mass, still more preferably 0.1 to 20 parts by mass, and most preferably 0.5 to 10 parts by mass.

  In the sheet-like product for skin of the present invention, the content of the component (II) is preferably 0.0005 to 20 parts by mass, more preferably 0.001 to 15 parts per 1 part by mass of the component (I). Part by mass, more preferably 0.01 to 12 parts by mass, most preferably 0.1 to 10 parts by mass.

  Moreover, in the sheet-like product for skin of the present invention, the total amount of the component (I) and the component (II) is preferably 0.01 to 60 parts by mass in 100 parts by mass of the sheet material to be described later. The amount is more preferably 0.05 to 50 parts by mass, still more preferably 0.1 to 40 parts by mass, and most preferably 0.5 to 30 parts by mass.

  If the total amount of the component (I) and the component (II) is less than 0.01 parts by mass, the effect of the present invention may not be felt, and if it exceeds 60 parts, the feeling of use is inferior. This is not preferable because it may occur.

The sheet product for skin of the present invention preferably further contains mevalonic acid. By containing mevalonic acid, a better moisturizing feeling can be imparted.
The mevalonic acid referred to in the present invention is involved in the biosynthesis metabolism of isoprenoid-related substances in a very large number of organisms in nature. Exists. In this specification, mevalonic acid and mevalonolactone are treated as synonyms.

  As a method for mass production of mevalonic acid, for example, methods of producing from microorganisms are known (Japanese Patent Publication No. 7-89938, Japanese Patent Publication No. 7-89939, Japanese Patent Publication No. 7-89940, Japanese Patent Publication No. 7- In this method, R-mevalonic acid which is a natural type can be obtained.

In addition, mevalonic acid obtained by chemical synthesis has two optical isomers, R-mevalonic acid and S-mevalonic acid. In the present invention, these racemates can be used as they are, Only natural R-mevalonic acid can be divided and used. Of course, it is also possible to divide and use only S-mevalonic acid.
The mevalonic acid used in the present invention is preferably natural R-mevalonic acid from the viewpoints of biocompatibility and safety.

  In the present invention, as the mevalonic acid, a monovalent or divalent metal salt of mevalonic acid, for example, a salt of sodium, potassium, calcium or the like, or an alcohol, for example, methyl alcohol, ethyl alcohol, butyl alcohol, propylene glycol Esters with glycerin, isopropyl alcohol and the like can also be used. R-mevalonate and S-mevalonate are present in the salt, and R-mevalonate and S-mevalonate are present in the ester, and these racemates can be used as they are. From the viewpoint of safety and safety, natural R-mevalonate and R-mevalonate are preferred.

  The content of mevalonic acid is preferably 0.001 to 10 parts by mass and more preferably 0.005 to 5 parts by mass in 100 parts by mass of a sheet material to be described later. If the amount is less than 0.001 part by mass, the effect of containing mevalonic acid may not be obtained, and even if the amount exceeds 10 parts by mass, an effect commensurate with the increase in the amount may not be expected.

  Examples of components that can be contained in addition to the components (I) and (II) of the sheet product for skin of the present invention include surfactants, chelating agents, plant-derived extracts, zinc compounds, thickeners, and oil agents. , Dyes, pigments, antibacterial agents, humectants, pH adjusters, antioxidants, ultraviolet absorbers, moisturizing components, enzymes, fragrances and the like.

  Examples of surfactants include anionic surfactants, nonionic surfactants, cationic surfactants and amphoteric surfactants. Examples of anionic surfactants include higher fatty acid salts, higher alcohol sulfates, sulfates. Olefin salt, higher alkyl sulfonate, α-olefin sulfonate, sulfated fatty acid salt, sulfonated fatty acid salt, phosphate ester salt, sulfate ester salt of fatty acid ester, glyceride sulfate ester salt, sulfonate salt of fatty acid ester, α-sulfo fatty acid methyl ester salt, polyoxyalkylene alkyl ether sulfate ester salt, polyoxyalkylene alkyl phenyl ether sulfate ester salt, polyoxyalkylene alkyl ether carboxylate salt, acylated peptide, fatty acid alkanolamide or alkylene oxide thereof Sulfuric acid ester salts of idoid adducts, sulfosuccinic acid esters, alkylbenzene sulfonates, alkylnaphthalene sulfonates, alkylbenzimidazole sulfonates, polyoxyalkylene sulfosuccinates, N-acyl-N-methyltaurine salts, N- Acyl glutamic acid or a salt thereof, acyloxyethane sulfonate, alkoxyethane sulfonate, N-acyl-β-alanine or a salt thereof, N-acyl-N-carboxyethyl taurine or a salt thereof, N-acyl-N-carboxymethyl Examples thereof include glycine or a salt thereof, acyl lactate, N-acyl sarcosine salt, and alkyl or alkenylaminocarboxymethyl sulfate.

  Nonionic surfactants include, for example, polyoxyalkylene alkyl ether, polyoxyalkylene alkenyl ether, polyoxyethylene polyoxypropylene alkyl ether (addition form of ethylene oxide and propylene oxide may be either random or block. ), Polyethylene glycol propylene oxide adduct, polypropylene glycol ethylene oxide adduct, glycerin fatty acid ester or its ethylene oxide adduct, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyl polyglucoside, fatty acid monoethanolamide or its ethylene oxide addition , Fatty acid-N-methylmonoethanolamide or its ethylene oxide adduct, fatty acid dietane Amide or ethylene oxide adducts, sucrose fatty acid esters, alkyl (poly) glycerol ether, polyglycerol fatty acid esters, polyethylene glycol fatty acid esters, fatty acid methyl ester ethoxylates, N- long chain alkyl dimethyl amine oxides, and the like.

  Examples of the cationic surfactant include alkyl (alkenyl) trimethyl ammonium salt, dialkyl (alkenyl) dimethyl ammonium salt, alkyl (alkenyl) quaternary ammonium salt, mono- or dialkyl (alkenyl) containing ether group, ester group or amide group. ) Quaternary ammonium salt, alkyl (alkenyl) pyridinium salt, alkyl (alkenyl) dimethylbenzyl ammonium salt, alkyl (alkenyl) isoquinolinium salt, dialkyl (alkenyl) morphonium salt, polyoxyethylene alkyl (alkenyl) amine, alkyl (alkenyl) amine Examples thereof include salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, and benzethonium chloride.

Examples of the amphoteric surfactant include carboxybetaine, sulfobetaine, phosphobetaine, amide amino acid, imidazolinium betaine surfactant and the like.
Examples of chelating agents include aminopolycarboxylic acid chelating agents, aromatic or aliphatic carboxylic acid chelating agents, amino acid chelating agents, ether polycarboxylic acid chelating agents, phosphonic acid chelating agents, phosphoric acid chelating agents, Examples include hydroxycarboxylic acid chelating agents, polymer electrolyte (including oligomer electrolyte) chelating agents, dimethylglyoxime, ascorbic acid, thioglycolic acid, phytic acid, glyoxylic acid, and glyoxalic acid. These chelating agents may be in the free acid form or in the form of a salt such as sodium salt, potassium salt, or ammonium salt. Furthermore, they may be in the form of their ester derivatives which are hydrolysable.

  Examples of the aminopolycarboxylic acid chelating agent include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, N- (2 -Hydroxyethyl) ethylenediaminetriacetic acid, glycol etherdiaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid and their salts.

  Examples of aromatic or aliphatic carboxylic acid chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvic acid, salicylic acid, Examples include acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranilic acid), phthalic acid, fumaric acid, trimellitic acid, gallic acid, hexahydrophthalic acid and salts thereof, methyl esters, and ethyl esters.

Examples of the amino acid chelating agent include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts and derivatives thereof.
Examples of the phosphonic acid-based chelating agent include iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof.
Examples of the phosphoric acid chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, and polyphosphoric acid.

Examples of the hydroxycarboxylic acid chelating agent include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartaric acid, lactic acid, and salts thereof.
Examples of the polymer electrolyte (including oligomer electrolyte) chelating agent include acrylic acid polymer, maleic anhydride polymer, α-hydroxyacrylic acid polymer, itaconic acid polymer, and two constituent monomers of these polymers. The copolymer which consists of the above and an epoxy succinic acid polymer are mentioned.

  Among these chelating agents, ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, aspartic acid diacetic acid, succinic acid are highly safe and have a great chelating effect. Acid, salicylic acid, oxalic acid, lactic acid, fumaric acid, citric acid, tartaric acid, 1-hydroxyethane-1,1-diphosphonic acid and salts thereof are preferred.

  The plant-derived extract is the whole plant or algae or fungi, or specific parts such as flowers, leaves, stems, fruits, bark, roots, seeds, resins, etc. From what is obtained by extracting with a solvent at normal temperature or under heating, it means what is dissolved in water, ethanol, propylene glycol or oil. Alternatively, the extract may be diluted, concentrated or dried. Further, it may be an essential oil obtained by using a steam distillation method, an extraction method, a chromatography method or the like.

  As an extraction solvent for plant-derived extracts, those usually used for extraction of natural product components, such as water; alcohols such as methanol, ethanol, propanol and butanol; polyvalent such as ethylene glycol, propylene glycol, butylene glycol and glycerin Alcohols; ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; ethers such as tetrahydrofuran, diethyl ether and polyethylene glycol; halogenated hydrocarbons such as dichloroethane and chloroform; petroleum ether, n-hexane, Aliphatic hydrocarbons such as cyclohexane; aromatic hydrocarbons such as toluene; pyridines; sodium chloride solution and the like. Water, ethanol, propylene glycol, and butylene glycol are particularly preferable.

  Plants that can be used as plant-derived extracts include, for example, arch chalk, almond, eye, Aisenhard thia polystacia, eyebright, blue-green agave, aomoji, acacia concina, acacia senegal, acacia senegal gum, acacia decreens, red clover, Akaharunire, Akayamajiou, Agi, Agrimonia eupatoria, Akebobi, Asagaokakaraksa, thistle, reed, ashitaba, ajugatsu kestanika, azuki, asunaro, asparagus, asparagus sine alice, acerola, asenayaku, asenayakashi, atlas Gaith Suleio Calps, Avenas Trigosa, Avocado, Ama, Amacha, Amacharu, Amadokoro, Amamo, Amiris Balsamifera, American Pikachi, America Shaw, American Shaw, American Carrot, Amomu Aromachiku, Aracasi, Arcana, Arctium Majus, Arctium Minus, Arnica, Arnica Mysonis, Alpinia Officinalum, Alfalfa (aka Muragosago), Aloe Vera, Ansange, Anzu , Angelica, Anti-risbrunellaria, Amperopsis grocedentata, Anmarok, Ikarisou, Izayoi-bara, Japanese knotweed, Italian cypress, Strawberry, Fig, Ichiyakuso, Ginkgo biloba, Itlan, Carob, Ibukitorano, Imosemiru, Nettle, Iranian squirrels , Iris Parida, Iwabenkei, Iwamituba, common bean, fennel, witania somunifera, turmeric, usubasaicin, moray moth, udo, sea urchin memo Ki, Ume, Uyaku, Urarakanzo, Uri, Urbarakutsuka, Urumus davidiana, Uncarriagementa, Unshu mikan, Ages, Eilan Thai, Edelweiss, Ezokogi, Ezosnake Strawberry, Ezosohagi, Echinashi, Echinaceaparida, Enishidae, Ebene , Jeremiah, Enju, Pea, Emperor juniper, Emperor, Soleum,

Auren, Great Thistle, Great White Sow, Great Ezo Denda, Great White Pea, Orchid McClata, Orchis Muscula, Orchid, Oak (aka European oak), Greater Grove, Greater Ochera, Greater Crested Oak, Greater Crested Owl, Greater Oyster Barley, Allspice, Okaseri, Okra, Oshiroirobana, Panax ginseng, Hypericum, Onigashi, Onisarubia, Oni radish, Onionis, Opuntia Streptacansa, Opuntia tuna, Dutch mustard, Dutch peonies, olives, Origanum herculone Neuus, Olmenis Murchikauris, Orange, Oroban Kerapum, Gardenia Tahitensis, Carnation, Kaya Negalensis, cacao, oysters, cassia, cashew nut, cascara sagrada, cassica talica, kappa ficus alvarez, cattleya, canadian hydrastis, canary tree, canina rose, valerian, birch anemone, turnip, gama (clam), camomile (aka camomile) , Kamimebouki, Kayupte, Karaku Sakeman, Osomugi, Osomugiwara, Karatouki, Guarana, Garikkabara, Cauliflower, Karin, Karuna (aka Goryumodoki), Garcinia Cambodia, Carrot, Kawarayomogi (aka Inchinkou), Kanzo, Kantaki Iki , Kikunigana, Kigeria africana, Kidachi aloe, Kidachi mint, Kinonaki, Quinoa, Yellowfin (aka Aoba), Kibanasushiro, Kibananohachiwama , Millet, gymnema, magnolia, cassava, cabbage, caraway, cucumber (aka Cucumber), Kyoou, Gyoryu, Gyoryba, Kiraya, Kiri, Gimbaika (aka honeysuckle), Guar, Guava, Quince Seed, Cuercus alba, Quinoki , Celandine, kudzu, camphor, damselfly, gardenia, bearberry, kumazasa, kumatsura,

Anemonefish, cumin, clamelia antriandra, clara, granberry, chrismum maritimum, grindelia albista, clintonia borealis, walnuts, grapefruit, clematis, black pepper, blackgurumi, black-bellied crispy, glove, black currant, black whale, mulberry, keiket , Kay (aka cinnamon), Geum Urbanum, Geum Rivere, Cape Aloe, Poppy, Geckavidin, Bay geuge, Ghetto, Kamiyama Kozolina, Gentian, Gentianana Prostrata, Gennoshouko, Kemponashi, Koki, Kokuchitan, Kokeiten, Kouyugaya, Kou Iga Cognevana, Coccinia indica, Cocktan, Cochlearia officinalis, Cowberry, Coconut palm, Go Strawberry, pepper, white clover, cochineal cactus, moth butterfly, moth orchid, konara, kochakobe, burdock, sesame, wheat, rice, koranoki, coriander, coleus, coleus barbatus, carambola, koroha, konsurango, confrey Tammicransum, Sisal Asa, Saisin, Cyperus Esculentus, Cypress, Cypress, South Rare Involcata, Saximas Button Kale, Sakura, Sakurabukanboku, Pomegranate, Sugar Maple, Sugarcane, Sugar Pine, Sasanca, Sassafrasoki, Saffron, Sabon Soup Salix nigra, crape myrtle, sanguinaria canadensis, hawthorn, sansikisumire, sanchinin carrot, sanshuyu, sansho , Sunpens, Citea medullaris, Cyanotis Arachnoidea, Shea butter, Shiozaki, Shisimbrium Irio, Sistrose (also known as Labdanum), Sistus monster periensis, Sisturanifels, Perilla, Sichenge, Linden, Shibamugi, Di Pterix odorata, Siberian fir, Shimaruba, Shigifugafrika, Shimotsuke, potato, Peonies, Jasmine, Janohige, Janome Erica, Shukusha, Juzudama, Gypsophila

Juniperus mexicana, Junsai, Ginger, Shozuk (also known as Cardamom), Shobu, Dioscorea, Birch, Silane, Rosy, Shirobanindokei, Shirobanarupin, Shirobanawata, Shinkonakarisaya, Synseparum dulcicum, Cymbidium, Sinprocosula , Sweet Acacia, Watermelon, Honeysuckle, Scabiosa Albensis, Horsetail, Scutellaria Galericulata, Stevia, Strobe Pine, Spiny Bamboo, Spirulina Platensis, Spirulina Maxima, Suberuille, Spelled Wheat, Sumino cherry, Sumilux Aristolochia ehoria, Acacia, Scots pine, Ionoki, Nettle, Psyllium, Hypericum, Kanocho , Pumpkin, quince, walrus carrot, quail, walnut, walnut, primrose, primrose, hawthorn, linden, white willow, dandelion, horned bud, horse chestnut, antelope, antelope Rowan, Ceylon Nikkei, Elderberry, Carrot Blossoms, Prunus serrata, Achillea millefolium, Hazel, Prunus mint, Holly, Prunus japonica, Prunus japonica, Prunus barley, Plover mistletoe, Prunus japonica, Ceylon crocodile Sihoria, Sequoia cedar, Cecil oak, Sedum purpleum, mallow, Negative, Geranium, Celcidium Florida, Celeus Grandiflorus, Celery, Senkyu, Centipelia Rose, Centipeda Kunningamimy, Senninkoku, Sempukuka, Semburi, Sojitsu, Sohakuhi, Saw Palmetto, Sokei, Buckwheat, Soranum Ricocarpum, Dai Fennel, radish, daisangiku, soybeans, taisou, daidai, scorpiona thyme, thyme, hinoki cypress, takasaburo, taro muskweed, tachibana, tablin, tabebuia abernedae, tamasaki tsuo rafuji, damask rose, onion, damiana, tarragon tan , Chigaya, tea (tea), chabotodia, tuberose,

Clove, Dung beetle, butterfly, chili attraction, Tsukushi-namo-honeybee, Clover, Tsurugumi, Tsurugukudami, Tsurureishi, Tea tree, Dioscorea composita, Dioscorea bilosa, Dioscorea mexicana, Teuchigurumi, Temakuriris, Tetsuzainoki, Duke , DuBoisley Cardiochi, Terminaria, Tencha, German iris, German spruce, capsicum, capsicum, spruce, spruce, spruce, spruce, spruce, spruce, corn, corn silk, capsicum, spruce, dodder, doginine Maizedaoshi), pepper, tomato, trigonellafoenum, tormentilla, torooioimodoki, nagagamishigishi, nagii kada, eggplant, nazuna, jujube, natsushi Giku, jujube, jujube, date palm, scorpionfish, nanbanai, nanbansafuji, scented mire, swordfish, scallop, sagebrush, sagebrush, shrimp , Noji Violet, Novara, Novorogiku, Pineapple, Hibiscus, Himatsu, Baobab, Bakuhorusia triodora, Bakumondo, Bacopa monniera, Hagoromogusa, lotus, parsley, patchouli, mint crepe, Baccarius genisteroides, Passiflora arata, Hagi Hana hakka, honeysuckle, vanilla, vanilla tahitensis, honeysenna, papaya, paphiopedilum maudae, haberlearod Nasis, Hermanus, Hamamelis, Hayatouri, Rose, Parietalia, Harienju, Harpagophytum, Palmarosa, Baros Mabetsurina, Banturmeric, Pansy, Bambara Beans, Beet, Holly Barberry, Hiogi, Hikiokoshi, Bisnagabella, Bitter Almond, Hitarska Dens Daisies, binankazura, pinusheda, cypress, hibamata,

Sunflower, Hippophaerumnoides, Sunflower, Himekouji, Himekora, Himetsunichinichiso, Himena Air Kulbaril, Himefuuro, Sandalwood, Chickpea, Hiramame, Himeharisou, Broadwater, Pirocarpus sp. , Pueraria Mirifica, Ferula Garvaniflua, Fukitanpopo, Bukkuryu, Fusazakisen, Fusagisuri, Fusafujitsugi, Fusanus Spicatus, Petit Glen, Petit Petalum Orakoidees, Bussouge, Butcher Bloom, Pterocarp Malspum, Grape, Motomo Beech, Fuyuzansha, Fuyubodaiju, Fuyumushinatsu Satake, Fragalia chiroensis, Brazil nut, French caganshaw, France Vendor, Plantagoafra, Plantagogobata, Plantagopsisium, Primula shikimensis, Prunes, Prunus africana, Prunus serotica, Plumeria, Plectrants barbatas, Bretcia hyacinthina, Propolis, Bay, Hayflower, Hazelnut, Pecan, Vetiver , Loofah, penny royal mint, sacred tree, safflower, safflower assembly, pepo pumpkin, hera plantain, pelargonium capitatum, helicrisum arenarium, helicopter angstiholium, helicris mutalycum, bergamot, pertoform dasarachis, peru Bergamot, Berberis aquiholium, Veronica caficinaris, henna, henrouda, scallop, boushuboku, boushunka, scallop, hou Ishida, Spinach, Hawkweed, Hoonoki, Hokubayofuroso, Bocoa Prouasensis, Boswellia Serata, Hosobasena, Hosobabarengiku, Bodaiju, Button, Hop, Poterium Officinale, Jojoba, Polygonatum mutiflorum, Bordo, Ponkan, Makade, Macade Officinalis, Magnolia Biondi, Magwa, Maggot, Masaki, Madake,

Pine, pine cricket, matecha, madonna lily, mayorana, maria thistle, marpigia grabra, quince, maronier, mango, mangosteen, manchua deer, manchua pine, manjugiku, mandarin orange, mandrake, mishima psycho, mizuhakka, mizuki mint, mizuki mint Mitsuga wrinkle, mitra carpath skaber, mimosate nuflora, mircaria dubia, myrrh (aka motsuyakuju), mirotamnus flaverifolia, mirobalan, mugwort, murasaki, murasakikibu, murasuki buran, murasaki bareniku, murayakoenji, burdock Lacta, Melissa (also known as Kousuihakka), Merirot, Melosria, Melon, Menta Albensis, Moukomugi, Moureraf Biachirisu, magnolia, moscata rose, moss bean, primrose, peach, peach tamana, yak moso, cornflower, yashabushi, willow willow, willow mint, willow, yamagwa, yamazakura, yamanomogi, yamayumogi, eupato, eupato D., Yukinoshita, Yuzu, Yuzuboku, Yucha, Yukkagurauka, Yukka Shijigera, Yuri, Yuzutsurumkinbai, Yuzusukizuki, Yodogakubo, Echinocercus, European European Strawberry, European Glycos, European Black Forest, European Birch, European Beech, European Mannengusa, European fir, Artemisia, Artemisia, Lychee (aka Reishi), Lima, Lime, Rye, Rye , Radiata pine, Latania, Peanut, Ranunculus ficaria, Labandula hybrida, Lahma, Lavender, Larix Europaea, Larea di Balicata, Larea Mexicana, Rambutan, Litho, Lithosam calumula, Litosea agglutinosa, Longan , Lirios maobataki, apple, rooibos, lupine bucarnos, lubus bilosus, lumpuyan, borage, lurihienso, lespedeza, lesdarteora, lettuce, redama, redam pulse train, lebanese cedar, levis chime officinale, lemon, lemongrass , Astragalus, Rosewood, Rosemary, Low Bush Blueberry, Roman Chamomile, Laurel (aka Laurel), Logwood, Robusta Coffee, Wild Time, Wasabi, Wasabi Plants such as radish, horseradish, cotton stalk, cotton bud, walteria indica, burberry, etc .;

Asco Film Nodosum, Aname, Oukimo, Okinawa Mozuku, Gigalchinasterata, Kujermaniela Girata, Sargassum Filipendula, Sargassum Fusifom, Sargassum Muticam, Sfaceraria scoparia, Durvillea Antarcica, Padina Pavonica Himantalia Elongata, Fucus Serats, Pervetian Canarikurata, Macrocystis pirifera, Mitsushi Kombu, Laminaria Ochroika, Laminaria Croustoni, Laminaria Diguitta, Laminaria Hiperborea, Wakame, Asparagopsis Armata, Igis, Kaguibaranori , Catamen giraffe rhinoceros, geridium curchira guineum, saimi, striped primrose, duls, chinolimo, tochaka, porphyridium cruentum, marbatis macronori Lysosamnium cororioides, anaoaosa, chlorella emersoni, chlorella pyrenoidosa, duna riela salina, duna riela daudawil, hiraaonori, spirulina platensis, spirulina maxima, hasrea austria, dereceria sanguinea, picarolobista Algae such as les, haematococcus prubiaris, cyanobacteria, condor crisps, corals, sea whip, red algae;

Examples include lichens and fungi such as Ebernia furfracea, horned moss, Usnia barbata, Oshagujitake, birch bamboo, shiitake mushroom, nymph mushroom, Japanese pine mushroom, Fuyushinatsutake, birch bamboo shoot, Cordillera edulis.

  Examples of the zinc compound include zinc acetate, zinc laurate, zinc myristate, zinc palmitate, zinc ricinoleate, zinc undecylenate, zinc aspartate, zinc acetylmethionine, zinc gluconate, zinc citrate, polypyrrolidone carboxylic acid Organic acid zinc salts such as zinc and zinc picolinate; Zinc sulfonic acid zinc salts such as zinc p-phenolsulfonate, Ascorbyl zinc phosphate, Sodium cetyl phosphate, zinc zinc phosphate such as DNA zinc; Zinc pyrithione and other zinc complexes Zinc supported zeolite such as (silver / zinc / ammonium) zeolite and silicic acid (ammonium / silver / zinc / aluminum); aluminum hydroxide such as aluminum oxide / zinc, aluminum oxide / zinc / cerium, aluminum oxide / zinc / iron Baked products such as sulfuric acid , Zinc sulfide, zinc chloride, zinc bromide, zinc nitrate, ammonium zinc chloride, zinc aluminum sulfate, potassium zinc sulfate, zinc iodide, basic zinc carbonate and other inorganic zinc salts; (hydroxide / carbonic acid) (Mg / Al / Zinc), zinc oxide and the like. Among these, a compound that easily dissolves in water to become zinc ions is preferable, the solubility in 100 g of water at 20 ° C. is preferably 5 g or more, and the solubility is more preferably 10 g or more. Examples of such zinc compounds include zinc sulfate, zinc chloride, zinc gluconate, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, potassium zinc sulfate, and zinc iodide.

  Examples of the thickener include dimethyldiallylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer, cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar , Gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabinogalactan, caraya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, β-1,3 Β-glucan other than -1,6-glucan, β-glucan derivatives, gellan gum, dextran, α-glucose, α-glucose derivatives and the like.

  Examples of the oil agent include volatile and non-volatile oil agents and solvents and resins that are usually used in sheet-like products for skin. A liquid, paste, or solid may be used at room temperature, but a liquid that is excellent in handling is preferable. Examples of the oil include lauric acid, undecylenic acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid, 12-hydroxystearic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid. Higher fatty acids such as acid, isostearic acid, 12-hydroxystearic acid, lanolin fatty acid; myristyl myristate, hexyl laurate, decyl oleate, isopropyl myristate, hexyl decyl dimethyloctanoate, glyceryl monostearate, diethyl phthalate, mono Ethylene glycol stearate, octyl oxystearate, diisopropyl adipate, cetyl octoate, isononyl isononanoate, isopropyl palmitate, stear stearate , Isotridecyl myristate, 2-ethylhexyl palmitate, octyldodecyl ricinoleate, fatty acid cholesteryl / lanosteryl having 10 to 30 carbon atoms, cetyl lactate, lanolin acetate, ethylene glycol di-2-ethylhexanoate, pentaerythritol Esters such as fatty acid esters, dipentaerythritol fatty acid esters, cetyl caprate, glyceryl tricaprylate, diisostearyl malate, dioctyl succinate, and cetyl 2-ethylhexanoate;

Hydrocarbons such as liquid paraffin, petroleum jelly and squalane; waxes such as lanolin, reduced lanolin and carnauba wax; fats and oils such as mink oil, cocoa butter, coconut oil, palm kernel oil, camellia oil, sesame oil, castor oil, olive oil; dimethylpolysiloxane , Methylhydrozine polysiloxane, methylphenyl polysiloxane, polyether-modified organopolysiloxane, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, fluorine-modified organopolysiloxane, amodimethicone , Silicone compounds such as amino-modified organopolysiloxane, silicone gel, acrylic silicone, trimethylsiloxysilicate, silicone RTV rubber; Fluorine compounds such as modified pitch, fluorocarbon, fluoroalcohol; Polybutene, polyisobutene, hydrogenated polyisobutene, polyolefins such as ethylene / α-olefin / co-oligomer or olefin oligomers; Mineral oil, light fluid isoparaffin, petroleum jelly, hydrocarbons such as squalane, etc. Is mentioned.

Examples of the dye include dyes such as Red No. 201, Yellow No. 4, Blue No. 1, and Black No. 401, and Lake Dye such as Yellow No. 4 Al lake and Yellow No. 203 Ba lake.
Examples of the pigment include white pigments such as titanium oxide, extender pigments such as silica, talc, mica, sericite, and kaolin, and pearl pigments such as mica titanium. There are no particular restrictions on the shape of these pigments (spherical, rod-like, needle-like, plate-like, indeterminate, flake-like, spindle-like, etc.). These pigments are conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, polyacrylic. The surface treatment may be performed in advance by acid treatment, metal soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment or the like.

Examples of the antibacterial agent include paraben antibacterial agents such as methylparaben and ethylparaben; imidazole antibacterial agents such as thiabendazole and 2-benzimidazolylcarbamate methylpreventol; and carbanide antibacterial agents such as trichlorocarbanilide and cloflucarban A thiazole antibacterial agent such as benzothiazole; a triazine antibacterial agent such as debuconazole and cabinone; and a biguanide antibacterial agent such as chlorhexidine hydrochloride and polyhexamethylene biguanide.
An antibacterial agent may mix | blend said 1 type, or 2 or more types.

Examples of the pH adjuster include potassium carbonate, sodium hydrogen carbonate, ammonium hydrogen carbonate and the like. These pH adjusters may be the same as or different from the acid base used for the preparation of the cationic surfactant composed of the tertiary amine and amidoamine.
A pH adjuster may mix | blend said 1 type (s) or 2 or more types.

Examples of the antioxidant include tocopherol, butylhydroxyanisole, dibutylhydroxytoluene, phytic acid and the like.
An antioxidant may mix | blend said 1 type (s) or 2 or more types.

Examples of the ultraviolet absorber include salicylic acid series such as homomenthyl salicylate, octyl salicylate, triethanolamine salicylate; paraaminobenzoic acid, ethyldihydroxypropylparaaminobenzoic acid, glycerylparaaminobenzoic acid, octyldimethylparaaminobenzoic acid, paradimethylaminobenzoic acid. PABA type such as amyl, 2-ethylhexyl paradimethylaminobenzoate; 4- (2-β-glucopyranosyloxy) propoxy-2-hydroxybenzophenone, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone disulfonate, 2-hydroxy -4-methoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and its trihydrate, hydroxymethoxybenzophenonesulfone Sodium, 2-hydroxy-4-methoxybenzophenone-5-sulfate, 2,2′-dihydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2,2′4,4′-tetrahydroxybenzophenone, 2, 2 Benzophenones such as'-dihydroxy-4,4'-dimethoxybenzophenone and 2-hydroxy-4-N-octoxybenzophenone; 2-ethylhexyl paramethoxycinnamate (also known as octyl paramethoxycinnamate), diparamethoxy Glyceryl mono-2-ethylhexanoate, methyl 2,5-diisopropylcinnamate, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5- Triazine, methyl bis (trimethylsiloxy) silylisopene trimethoxycinnamate Cinnamate systems such as p-methoxy cinnamate / diisopropyl cinnamate ester mixture, p-methoxyhydrocinnamic acid diethanolamine salt; 2-phenyl-benzimidazole-5-sulfate, 4-isopropyldibenzoylmethane, Benzoylmethane such as 4-tert-butyl-4′-methoxydibenzoylmethane; 2-cyano-, 3-diphenylprop-2-enoic acid 2-ethylhexyl ester (also known as octocrylene), dimethoxybenzylidene dioxoimidazolidinepropion 2-ethylhexyl acid, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, synoxate, methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3, 3-diphenyl acrylate, 3- (4- Methylbenzylidene) camphor, octyltriazone, 4- (3,4-dimethoxyphenylmethylene) -2,5-dioxo-1-imidazolidinepropionate 2-ethylhexyl, their polymer derivatives, and silane derivatives.
An ultraviolet absorber may mix | blend said 1 type (s) or 2 or more types.

Examples of moisturizing ingredients include deoxyribonucleic acid, mucopolysaccharide, chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membrane, polyoxyethylene methyl glucoside, polyoxypropylene methyl glucoside, sodium lactate, urea, pyrrolidone carboxylic acid Sodium, betaine, whey and the like can be mentioned.
One or two or more moisturizing components may be blended.

Examples of the enzyme include acylcoenzyme A desaturase, aminopeptidase, amyloglucosidase, oxidoreductase, catalase, glucose oxidase, superoxide dismutase, soybean peroxidase, dextran-immobilized protease, transglutaminase, hyaluronidase, protease, hesperidinase, lactoperoxidase, lipase Etc.
An enzyme may mix | blend said 1 type (s) or 2 or more types.

A fragrance | flavor is mix | blended in order to give a fragrance and fragrance to the sheet-like product for skin, or to mask an unpleasant odor. It is not particularly limited as long as it is a fragrance generally blended into a sheet product for skin, and includes various extracts such as the above-mentioned physiologically active ingredients, flowers, seeds, leaves, roots of various plants. Fragrances extracted from seaweeds, fragrances extracted from seaweeds, fragrances extracted from animal parts or secretions (eg Jakko, sperm), artificially synthesized fragrances (eg menthol, musk, acetate, vanilla) ) Is exemplified.
A fragrance | flavor may mix | blend said 1 type, or 2 or more types.

The sheet product for skin of the present invention is obtained by impregnating a sheet material with the components (I) and (II) and other components as required.
The material of the sheet material is not particularly limited, and examples thereof include water-absorbing materials such as non-woven fabrics, woven fabrics, paper, and sponges that are generally used for skin sheet products.

  The skin-like product of the present invention is suitable for a wide range of uses such as wet tissue, wet wiper, lotion tissue, wipes, body cleansing sheet, wipe wipe, nursing wiper, makeup remover sheet, face mask, UV care sheet, etc. Can be used.

Finally, a method for improving the feeling of use of the skin-like product of the present invention will be described.
The method for improving the feeling of use of the sheet product for skin of the present invention comprises the following components (I) and (II).
(I) One or more selected from the group consisting of low molecular polyols and higher alcohols
(II) β-1,3-1,6-glucan

  According to the method for improving the feeling of use of the sheet-like product for skin of the present invention, even when an irritating component is contained, the irritation to the skin is suppressed, and it has a smooth and smooth feeling of use. It becomes a sheet-like product for skin that is excellent in moisturizing effect after use.

  Hereinafter, the present invention will be specifically described by way of examples. In the following examples and the like, “%” and “ppm” are “mass basis” unless otherwise specified.

Preparation of sample A Black yeast (deposit number FERM BP-8391) was cultured on a potato dextrose agar slant medium to form a stock strain, and inoculated into a 500 ml Erlenmeyer flask containing 100 ml of YM liquid medium (Difco). Pre-cultured at 28 ° C. for 3 days. This culture solution was transferred to a 30 liter fermenter containing 15 liters of Czapeak's medium (Difco) and cultured at 28 ° C. for 3 days. The culture broth was sterilized by heating at 90 ° C. for 30 minutes, and then the cells were removed by centrifugation to obtain a culture supernatant. The β-1,3-1,6-glucan contained in the culture supernatant is a compound having a ratio of b to a of 0.85 and a mass average molecular weight of 300,000 in the general formula (1). It was.
A sample A was obtained by spray-drying the obtained culture supernatant.

Preparation of Sample B Sample B was laminarin as β-1,3-1,6-glucan (in the general formula (1), the ratio of b to a was 0.33 and the mass average molecular weight was 5000).

[Examples 1 to 11 and Comparative Example]
250 parts by mass of the chemicals A to L having the composition described in Table 1 are impregnated with respect to 100 parts by mass of the nonwoven fabric to obtain the sheet product A to K for skin of the present invention and the sheet product L for skin that is a comparative example. It was.

Evaluation of the sheet product for skin 10 Forearms of 10 subjects (6 men and 4 women) were rubbed with the wiping sheet, and this was performed for 2 weeks. The following criteria evaluated the feeling of use after 2 weeks of use, the moist feeling after use, and skin irritation. Specifically, each test subject evaluated any three types of the comparative example and the example in the same period, and each example calculated the average of the scores of five people (three men and two women).
The results are shown in Table 2.

-Evaluation of feeling of use 5 points: A smooth and smooth feeling of use and very good 3 points: A feeling of smooth use and good 1 point: A feeling of rough use

・ Evaluation after use: 5 points: Sustained feeling of moistness is very good. 3 points: Moisture feeling is sustained to some extent.

・ Evaluation of skin irritation: 5 points: No irritation caused by impregnating solution
3 points: Slight irritation from impregnation liquid 1 point: Irritation from impregnation liquid

・ Skin roughness assessment by continuous use 5 points: No skin roughness observed 3 points: Slight skin roughness observed 1 point: Skin roughness observed, painful

Example of lotion tissue production:
A drug solution consisting of 10 parts by mass of glycerin, 0.1 part by mass of β-1,3-1,6-glucan (sample A) and 89.9 parts by mass of water was sprayed on a commercially available tissue paper. (The amount of spray is 2 parts by mass of chemicals for 1 part by mass of tissue paper)
Then, it was slowly dried over 48 hours under conditions of room temperature of 25 ° C. and humidity of 50% to obtain a lotion tissue that is a sheet product for skin of the present invention.
The resulting lotion tissue had a very light and smooth feel.

Claims (7)

A skin-like product comprising the following components (I) and (II):
(I) One or more selected from the group consisting of low molecular polyols and higher alcohols (excluding β-1,3-1,6-glucan)
(II) β-1,3-1,6-glucan The sheet-like product for skin according to claim 1, wherein β-1,3-1,6-glucan is β-glucan represented by the following general formula (1):

  The ratio of b of a with respect to a of General formula (1) is 0.2-1, The sheet-like product for skin of Claim 2 characterized by the above-mentioned.   The sheet-like product for skin according to any one of claims 1 to 3, wherein 0.0005 to 20 parts by mass of the component (II) is contained per 1 part by mass of the component (I).   The sheet-like product for skin according to any one of claims 1 to 4, wherein the total amount of the component (I) and the component (II) is 0.01 to 60 parts by mass with respect to 100 parts by mass of the sheet material.   The sheet-like product for skin according to any one of claims 1 to 5, comprising mevalonic acid. A method for improving the feeling of use of a sheet product for skin, comprising the following components (I) and (II):
(I) One or more selected from the group consisting of low molecular polyols and higher alcohols (excluding β-1,3-1,6-glucan)
(II) β-1,3-1,6-glucan