JP6865744B2 - Antibacterial composition, cosmetic composition containing it and sheet-like product for skin - Google Patents

Description

The present invention relates to an antibacterial composition that can be used in cosmetics and the like. More specifically, with respect to a hypoallergenic antibacterial composition containing a diol compound having a specific structure and a cationic compound having a specific structure, the antibacterial composition is used for cosmetics, skin sheet products and the like. Can be used.

Antibacterial agents are usually used for cosmetics and cleaning agents for the purpose of preservatives and the like. Parabens are the most used as such antibacterial agents. Although parabens are less toxic, they have the disadvantage that the range of concentration used is limited due to their high skin irritation. Therefore, the concentration of parabens used in cosmetics is limited to 1% or less. In recent years, the number of people who have an allergic reaction to parabens is increasing. People who have an allergic reaction also react to extremely low concentrations of parabens, so the demand for cosmetics that do not contain parabens is increasing. However, cosmetics that do not use antibacterial agents have poor storage stability and are difficult to manage as commercial products, so antibacterial agents that are highly safe for the human body have been sought.

Diol compounds such as alkanediols and alkylglyceryl ethers and compounds in which an alkylene oxide is added to these diol compounds are known as antibacterial substances having higher safety to the human body than parabens (for example). See Patent Documents 1 to 3). Further, it is known that a cationic compound having an ester group or an amide group has relatively low skin irritation and high antibacterial property (see, for example, Patent Documents 4 to 6).

Japanese Unexamined Patent Publication No. 2005-170878 Japanese Unexamined Patent Publication No. 2007-016018 Japanese Unexamined Patent Publication No. 2007-161651 Japanese Unexamined Patent Publication No. 2000-178104 JP-A-2002-302406 Japanese Unexamined Patent Publication No. 2003-081709

However, the antibacterial properties of alkanediols and alkylglyceryl ethers are not sufficient, and cationic compounds having an ester group or an amide group may cause skin irritation when used to a concentration that exhibits antibacterial properties. ..

As a result of diligent studies to solve the above problems, the present inventors have obtained antibacterial properties when a combination of alkanediols or alkylglyceryl ethers having two hydroxy groups at the ends and a cationic compound having an ester group or an amide group is used. It was found that the synergistic effect of the above was exhibited, and the present invention was completed. That is, the present invention comprises at least one diol compound selected from the group consisting of the component (A) which is a compound represented by the following general formula (1) and the compound represented by the following general formula (2), and It is an antibacterial composition containing the component (B) which is at least one cationic compound selected from the group consisting of the compounds represented by the following general formulas (3) to (5).

(In the formula, R ¹ represents an alkyl group having 4 to 8 carbon atoms.)

(In the formula, R ² represents an alkyl group having 5 to 10 carbon atoms, a cycloalkyl group having 6 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, or an aralkyl group having 7 to 10 carbon atoms.)

(In the formula, R ³ represents an alkyl group having 5 to 10 carbon atoms, R ⁴ represents a hydrocarbon group having 1 to 8 carbon atoms, R ⁵ represents a methyl group, an ethyl group or a benzyl group, and X represents a methyl group, an ethyl group or a benzyl group. It represents a chlorine atom, a bromine atom, an iodine atom, a methyl sulfate group or an ethyl sulfate group, and a represents a number of 1 to 3).

(In the formula, R ⁶ represents a pentyl group, a hexyl group, a heptyl group, an octyl group or a nonyl group , R ⁷ represents a hydrocarbon group having 1 to 8 carbon atoms, and R ⁸ represents a methyl group, an ethyl group or a benzyl group. , Z represents a chlorine atom, a bromine atom, a iodine atom, a methyl sulfate group or an ethyl sulfate group, and b represents a number of 1 to 3).

(In the formula, R ⁹ represents an alkyl group having 5 to 10 carbon atoms, R ¹⁰ represents a hydrogen atom, a methyl group or an ethyl group, and R ¹¹ represents a hydrogen atom or a group represented by the following general formula (6). ^{R 12} represents a methyl group, an ethyl group or a benzyl group, Q represents a chlorine atom, a bromine atom, a iodine atom, a methyl sulfate group or an ethyl sulfate group, and c represents a number 1 to 3).

（式中、Ｒ¹³は炭素数５〜１０のアルキル基を表わす。）

(In the formula, R ¹³ represents an alkyl group having 5 to 10 carbon atoms.)

By combining the diol compound having a specific structure as the component (A) of the present invention and the cationic compound having a specific structure as the component (B), the antibacterial action of each compound is synergistically enhanced. .. In addition, the composition containing the components (A) and (B) has high antibacterial properties but low irritation. Therefore, this composition can be effectively used in cosmetics as an antibacterial composition. Further, by using this antibacterial composition, it is possible to provide a skin sheet-like product having high antibacterial property and low irritation.

Among the components (A) of the present invention, the diol compound represented by the general formula (1) will be described. In the general formula (1), R ¹ represents an alkyl group having 4 to 8 carbon atoms. Alkyl groups having 4 to 8 carbon atoms include butyl groups, isobutyl groups, secondary butyl groups, t-butyl groups, pentyl groups, isopentyl groups, secondary pentyl groups, t-pentyl groups, hexyl groups, and secondary hexyl groups. , Heptyl group, secondary heptyl group, octyl group, secondary octyl group, 2-methylpentyl group, 2-ethylhexyl group and the like. As R ¹ , a butyl group, a pentyl group, a hexyl group, a heptyl group, and an octyl group are preferable, a pentyl group and a hexyl group are more preferable, and a hexyl group is the most preferable, because they have high antibacterial properties. Preferred specific examples of the diol compound represented by the general formula (1) include 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol and the like. Of these, 1,2-hexanediol and 1,2-octanediol are particularly preferable.

Next, among the components (A) of the present invention, the glyceryl ether compound represented by the general formula (2) will be described. In the general formula (2), R ² represents an alkyl group having 5 to 10 carbon atoms, a cycloalkyl group having 6 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, or an aralkyl group having 7 to 10 carbon atoms. Examples of the alkyl group having 5 to 10 carbon atoms include a pentyl group, an isopentyl group, a secondary pentyl group, a t-pentyl group, a hexyl group, a secondary hexyl group, a heptyl group, a secondary heptyl group, an octyl group and a secondary octyl group. , Nonyl group, secondary nonyl group, decyl group, secondary decyl group, 2-methylpentyl group, 2-ethylhexyl group, 2-propylheptyl group, 2,2,4,4-tetramethylpentyl group and the like. Be done. Examples of the cycloalkyl group having 6 to 10 carbon atoms include a cyclohexyl group, a cycloheptyl group, a methylcyclopentyl group, a methylcyclohexyl group, a dimethylcyclohexyl group, a methylcycloheptyl group and the like. Examples of the aryl group having 6 to 10 carbon atoms include a phenyl group, a methylphenyl group, a dimethylphenyl group, an ethylphenyl group, an isopropylphenyl group, a t-butylphenyl group, an α-naphthyl group, a β-naphthyl group and the like. Be done. Examples of the aralkyl group having 7 to 10 carbon atoms include a phenylmethyl group, a 2-phenylethyl group, a 2-phenyl-2-propyl group and a 3-phenylpropyl group.

Since R ² has high antibacterial properties, it has a hexyl group, a heptyl group, an octyl group, a nonyl group, a 2-ethylhexyl group, a 2,2,4,4-tetramethylpentyl group, a phenyl group, a methylphenyl group and a cyclohexyl. A group and a phenylmethyl group are preferable, a hexyl group, a heptyl group, an octyl group, a 2-ethylhexyl group and a cyclohexyl group are more preferable, and a 2-ethylhexyl group is most preferable. Further, a hexyl group and a cyclohexyl group are preferable from the viewpoint of reducing the irritation of the component (B). Preferred specific examples of the glyceryl ether compound represented by the general formula (2) include, for example, 1-hexyl glyceryl ether, 1-heptyl glyceryl ether, 1-octyl glyceryl ether, 1-nonyl glyceryl ether, 1- (2). -Ethylhexyl) glyceryl ether, 1- (2,2,4,4-tetramethylpentyl) glyceryl ether, 1-phenyl glyceryl ether, 1-methylphenyl glyceryl ether, 1-cyclohexyl glyceryl ether, 1-phenylmethyl glyceryl ether, etc. Can be mentioned. Of these, 1-hexyl glyceryl ether, 1- (2-ethylhexyl) glyceryl ether and 1-cyclohexyl glyceryl ether are particularly preferable.

Among the components (B), the compound represented by the general formula (3) will be described. In the general formula (3), R ³ represents an alkyl group having 5 to 10 carbon atoms. Examples of the alkyl group having 5 to 10 carbon atoms include a pentyl group, an isopentyl group, a secondary pentyl group, a t-pentyl group, a hexyl group, a secondary hexyl group, a heptyl group, a secondary heptyl group, an octyl group and a secondary octyl group. , 2-Methylpentyl group, 2-ethylhexyl group, nonyl group, secondary nonyl group, decyl group, secondary decyl group, 2,2,4,4-tetramethylpentyl group and the like. As R ³ , a pentyl group, a hexyl group, a heptyl group, an octyl group, a nonyl group and a decyl group are preferable, and a hexyl group, a heptyl group, an octyl group and a nonyl group are more preferable, and a heptyl group and a nonyl group are preferable because they have excellent antibacterial properties. The nonyl group is even more preferred, and the heptyl group is most preferred. If there are a plurality of R ³ in the molecule may be the same group or a different group.

In the general formula (3), R ⁴ represents a hydrocarbon group having 1 to 8 carbon atoms. The hydrocarbon group having 1 to 8 carbon atoms includes a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, a secondary butyl group, a t-butyl group, a pentyl group, an isopentyl group, and a secondary pentyl group. , T-pentyl group, hexyl group, secondary hexyl group, heptyl group, secondary heptyl group, octyl group, secondary octyl group, 2-methylpentyl group, 2-ethylhexyl group, vinyl group, allyl group, propenyl group, Examples thereof include a butenyl group, an isobutenyl group, a pentanyl group, an isopentenyl group, a hexenyl group, a heptenyl group, an octenyl group, a cyclohexyl group, a phenyl group, a methylphenyl group and a benzyl group. Since R ⁴ has excellent antibacterial properties, it has a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, a secondary butyl group, a t-butyl group, a pentyl group, an isopentyl group, and a secondary pentyl group. , T-Pentyl group, hexyl group, secondary hexyl group, heptyl group, secondary heptyl group, octyl group, secondary octyl group, 2-methylpentyl group, 2-ethylhexyl group, vinyl group, allyl group, propenyl group, Examples thereof include a butenyl group, an isobutenyl group, a pentyl group, an isopentenyl group, a hexenyl group, a heptenyl group, an octenyl group, a cyclohexyl group, a phenyl group, a methylphenyl group and a benzyl group. As R ⁴ , since it is excellent in antibacterial properties, a methyl group, an ethyl group, a butyl group and a cyclohexyl group are preferable, and a methyl group is more preferable.

In the general formula (3), R ⁵ represents a methyl group, an ethyl group or a benzyl group, and is excellent in antibacterial properties. Therefore, a methyl group is preferable.

X represents a chlorine atom, a bromine atom, an iodine atom, a methyl sulfate group or an ethyl sulfate group, and a chlorine atom is preferable because the raw material is easily available and the antibacterial property is excellent. a represents a number of 1 to 3, and 2 is preferable because it has excellent antibacterial properties.
As the cationic compound of the above general formula (3), specifically, in the present invention, a compound in which R ³ is a heptyl group, R ⁴ and R ⁵ are methyl groups, X is a chlorine atom, and a is 2. Can be used. Similarly, as the cationic compound of the general formula (3), a compound in which R ³ is a nonyl group, R ⁴ and R ⁵ are methyl groups, X is a chlorine atom, and a is 2 can be preferably used. ..

The compound represented by the general formula (3) is obtained by esterifying the alkanolamine compound represented by the general formula (3a) as shown in the reaction formula below by a known method to obtain an ester compound represented by the general formula (3b). Further, it can be produced by cationization with a compound represented by the general formula (3c).

(In the formula, R ^{3 to} R ⁵ , X and a are synonymous with the general formula (3).)

Among the components (B), the compound represented by the general formula (4) will be described. In the general formula (4), R ⁶ represents an alkyl group having 5 to 10 carbon atoms. Examples of the alkyl group having 5 to 10 carbon atoms include the alkyl group exemplified by ^{R 3 of the general formula (3).} As R ⁶ , a pentyl group, a hexyl group, a heptyl group, an octyl group, a nonyl group and a decyl group are preferable, a heptyl group, an octyl group and a nonyl group are more preferable, and a heptyl group and a nonyl group are preferable because they are excellent in antibacterial properties. Even more preferred, the heptyl group is most preferred. When the R ⁶ have multiple in the molecule may be the same group or a different group.

In the general formula (4), R ⁷ represents a hydrocarbon group having 1 to 8 carbon atoms. Examples of the hydrocarbon group having 1 to 8 carbon atoms include the alkyl group exemplified by ^{R 4 of the general formula (3).} As R ⁷ , since it is excellent in antibacterial properties, a methyl group, an ethyl group, a butyl group and a cyclohexyl group are preferable, and a methyl group is more preferable.

In the general formula (4), R ⁸ represents a methyl group, an ethyl group or a benzyl group, and is excellent in antibacterial properties. Therefore, a methyl group is preferable.

Z represents a chlorine atom, a bromine atom, an iodine atom, a methyl sulfate group or an ethyl sulfate group, and a chlorine atom is preferable because the raw material is easily available and the antibacterial property is excellent. b represents a number of 1 to 3, and 2 is preferable because it has excellent antibacterial properties.
As the cationic compound of the above general formula (4), specifically, in the present invention, a compound in which R ⁶ is a heptyl group, R ⁷ and R ⁸ are methyl groups, Z is a chlorine atom, and b is 2. Can be used. Similarly, as the cationic compound of the general formula (4), a compound in which R ⁶ is a nonyl group, R ⁷ and R ⁸ are methyl groups, Z is a chlorine atom, and b is 2 can be preferably used. ..

The compound represented by the general formula (4) is obtained by amidating the amine compound represented by the general formula (4a) as shown in the following reaction formula by a known method to obtain an amide compound represented by the general formula (4b). It can be produced by cationization with a compound represented by the general formula (4c).

(In the formula, R ^{6 to} R ⁸ , Z and b are synonymous with the general formula (4).)

Among the components (B), the compound represented by the general formula (5) will be described. In the general formula (5), R ⁹ represents an alkyl group having 5 to 11 carbon atoms. Examples of the alkyl group having 5 to 11 carbon atoms include the alkyl group exemplified by ^{R 3 of the general formula (3).} As R ⁹ , a pentyl group, a hexyl group, a heptyl group, an octyl group, a nonyl group and a decyl group are preferable, a heptyl group, an octyl group and a nonyl group are more preferable, and a heptyl group and a nonyl group are preferable because they are excellent in antibacterial properties. Even more preferable. When the R ⁹ there are a plurality in the molecule may be the same group or a different group.

In the general formula (5), R ¹⁰ represents a hydrogen atom, a methyl group or an ethyl group, and is excellent in antibacterial properties. Therefore, a hydrogen atom is preferable. R ¹¹ represents a hydrogen atom or a group represented by the general formula (6). In the general formula (6), R ¹³ represents an alkyl group having 5 to 10 carbon atoms. Examples of the alkyl group having 5 to 10 carbon atoms include the alkyl group exemplified by ^{R 3 of the general formula (3).} Since R ¹¹ has excellent antibacterial properties, it is preferably a hydrogen atom or R ¹³ in the general formula (6) is a pentyl group, a hexyl group, a heptyl group, an octyl group, a nonyl group, or a decyl group. ^{, A hydrogen atom, or R 13} in the general formula (6) is more preferably a heptyl group, an octyl group, a nonyl group, and a hydrogen atom, or R ¹³ in the general formula (6) is a heptyl. It is even more preferable that it is a group, and it is most ^{preferable that R 13} in the general formula (6) is a heptyl group. When the group represented by the general formula (6) is an alkyl group having 5 to 10 carbon atoms, the group represented by the general formula (6) may be the same group as ^{R 6 or a different group.}

Q represents a chlorine atom, a bromine atom, an iodine atom, a methyl sulfate group or an ethyl sulfate group, and a chlorine atom is preferable because the raw material is easily available and the antibacterial property is excellent. c represents 1-3. Note that c indicates a repeating unit _{of [CH 2} CR ^{10 HO].}
As the cationic compound of the above general formula (5), specifically, in the present invention, a compound in which R ⁹ is a heptyl group, R ¹⁰ and R ¹¹ are methyl groups, Q is a chlorine atom, and c is 1. Can be used. Similarly, as the cationic compound of the general formula (5), R ⁹ is a nonyl group, R ¹⁰ is a hydrogen atom, R ¹¹ is a group represented by the general formula (6), and R ¹³ is a nonyl group. A compound in which Q is a chlorine atom and c is 1 can be preferably used.

The compound represented by the general formula (5) is obtained by amidating the amine compound represented by the general formula (5a) as shown in the reaction formula below by a known method to obtain an amide compound represented by the general formula (5b). An epoxy compound represented by the formula (5c) is added to obtain a compound represented by (5d), and if necessary, the compound is esterified by a known method to obtain a compound represented by (5e), and then the general formula (5f) is used. It can be produced by cationization with a compound represented by.

(In the formula, R ^{9 to} R ¹² , Q and c are synonymous with the general formula (5).)

The blending ratio of the component (B) to the component (A) is not particularly limited, but the ratio of the component (B) to 100 parts by mass of the component (A) is preferably 0.01 to 20 parts by mass, and 0.03 to 0.03. It is more preferably 10 parts by mass, and most preferably 0.05 to 5 parts by mass. When the ratio of the component (B) to 100 parts by mass of the component (A) is 0.01 parts by mass or more, a sufficient synergistic effect of antibacterial properties can be expected, and the ratio of the component (B) to 100 parts by mass of the component (A) When is 20 parts by mass or less, the problem of skin irritation does not occur.

The concentrations of the component (A) and the component (B) in the antibacterial composition of the present invention vary depending on the mode of use of the antibacterial composition and the product to be used, and are not particularly limited. However, the total amount of the component (A) and the component (B) is preferably 0.001 to 10% by mass, more preferably 0.01 to 2% by mass, based on the total amount of the antibacterial composition of the present invention. 05 to 1.5% by mass is more preferable. If the total amount of the component (A) and the component (B) is excessively small, the antibacterial effect may not be expected, while if it is very high, the effect commensurate with the amount may not be obtained. Further, when the antibacterial composition of the present invention is a product such as a cosmetic or a skin sheet shown below, the total amount of the component (A) and the component (B) is 0.001 with respect to the total amount of the product. It is preferably from 10% by mass, more preferably 0.01 to 2% by mass, still more preferably 0.05 to 1.5% by mass.

Since the antibacterial composition of the present invention enhances the antibacterial effect, it is preferable to further contain a chelating agent as the component (C). Examples of the chelating agent include aminopolycarboxylic acid-based chelating agents, aromatic or aliphatic carboxylic acid-based chelating agents, amino acid-based chelating agents, ether polycarboxylic acid-based chelating agents, phosphonic acid-based chelating agents, and phosphoric acid chelating agents. Examples thereof include hydroxycarboxylic acid chelating agents, high molecular weight electrolyte (including oligomeric electrolyte) chelating agents, dimethyl glyoxime, ascorbic acid, thioglycolic acid, phytic acid, glyoxylic acid, and glyoxal acid. Each of these chelating agents may be in the form of a free acid or in the form of a salt such as a sodium salt, a potassium salt or an ammonium salt. Furthermore, they may be hydrolyzable form status of their ester derivatives.

Examples of the aminopolycarboxylic acid-based chelating agent include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, and N- (2). -Hydroxyethyl) ethylenediaminetriacetic acid, glycol etherdiaminetetraacetic acid, glutamate diacetic acid, aspartate diacetic acid and salts thereof.

Examples of aromatic or aliphatic carboxylic acid-based chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvate, and salicylic acid. Examples thereof include acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranylic acid), phthalic acid, fumaric acid, trimellitic acid, gallic acid, hexahydrophthalic acid and salts thereof, methyl esters and ethyl esters.

Examples of amino acid-based chelating agents include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine and salts and derivatives thereof.

Examples of the hydroxycarboxylic acid-based chelating agent include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartrate acid, lactic acid and salts thereof.

Examples of the phosphonic acid-based chelating agent include iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid and salts thereof.

Examples of the phosphoric acid-based chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid and polyphosphoric acid.

Examples of the polymer electrolyte (including oligomeric electrolyte) chelating agent include an acrylic acid polymer, a maleic anhydride polymer, an α-hydroxyacrylic acid polymer, an itaconic acid polymer, and two constituent monomers of these polymers. Examples thereof include a copolymer composed of the above and an epoxy succinic acid polymer.

Among these chelating agents, ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, glutamate diacetic acid, aspartate diacetic acid, succinic acid, salicylic acid, oxalic acid, lactic acid. , Fumaric acid, citric acid, tartaric acid, 1-hydroxyethane-1,1-diphosphonic acid and salts thereof are preferred, ethylenediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diglutamate. Acetic acid, diacetic acid aspartate, succinic acid, lactic acid, tartaric acid and salts thereof are more preferable, and ethylenediaminetetraacetic acid, diacetic acid glutamate, diacetic acid aspartate and salts thereof are most preferable. Further, as a chelating agent in the form of a salt, ethylenediaminetetraacetic acid and sodium citrate are also preferable.

The amount of the chelating agent to be blended is not limited as long as the effect of the present invention is exhibited, but the blending amount of the chelating agent is preferably 0.5 to 500 parts by mass with respect to 100 parts by mass of the component (A), preferably 1 to 200 parts by mass. More preferably, 2 to 50 parts by mass is most preferable. If the blending amount of the chelating agent is less than 0.5 parts by mass with respect to 100 parts by mass of the component (A), the effect of improving the antibacterial property due to the addition of the chelating agent may not be obtained, and the effect of improving the antibacterial property due to the addition of the chelating agent may not be obtained. If it exceeds 500 parts by mass with respect to the part, the improvement of antibacterial property corresponding to the addition amount may not be obtained.

Since the antibacterial composition of the present invention enhances the antibacterial effect, it is preferable that the antibacterial composition further contains a low molecular weight polyol as the component (D). In the present invention, as the low-molecular-weight D) component of the component (D), as the low-molecular-weight polyol D) component, the low-molecular-weight polyol is a polyol having a molecular weight of less than 500 and refers to a compound other than the component (A).

Examples of the low molecular weight polyol include ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3-propanediol, 1,2-butanediol, and 1,3-. Butanediol, 1,4-butanediol, 2,3-butanediol, 2-methyl-1,2-propanediol, 2-methyl-1,3-propanediol, 1,2-pentanediol, 1,3- Pentandiol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2-methyl-1,2-butanediol, 2-methyl-2,3- Butanediol, 2-methyl-1,4-butanediol, 3-methyl-1,2-butanediol, 3-methyl-1,3 butanediol, 2-ethyl-1,3-propanediol, 2,2- Diol-1,3-propanediol, 1,5-hexanediol, 1,6-hexanediol, 2,5-hexanediol, 3,3-hexanediol, 2-methyl-1,3-pentanediol, 2- Methyl-1,5-pentanediol, 2-methyl-2,4-pentanediol, 3-methyl-1,5-pentanediol, 3-methyl-2,3-pentanediol, 3-methyl-2,4- Pentandiol, 2-ethyl-2-methyl-1,3-propanediol, 2,2-dimethyl-1,3-butanediol, 1,7-heptanediol, 3,4-heptanediol, 2-propyl-2 -Methyl-1,3-propanediol, 2-isopropyl-2-methyl-1,3-propanediol, 1,8-octanediol, 3,6-octanediol, 2-ethyl-1,3-hexanediol, 2-sec-Butyl-2-butyl-1,3-propanediol, 2,2-dimethyl-1,3-hexanediol, 2,5-dimethyl-2,5-hexanediol, 2,2,4-trimethyl -1,3-pentanediol, 1,3-nonanediol, 1,9-nonanediol, 3,6-octanediol, 2-ethyl-2- (2-methylpropyl) -1,3-propanediol, 2 , 2,4-trimethyl-1,6-hexanediol, 2,4,4-trimethyl-1,6-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 2,4-diethyl- 1,5-pe Enterandiol, 2-methyl-1,8-octanediol, 1,10-decanediol, 5,6-decanediol, 3,6-dimethyl-3,6-octanediol, 3,7-dimethyl-1,6 -Octanediol, 3,7-dimethyl-1,7-octanediol, 1,2-undecanediol, 1,4-undecanediol, 1,11-undecanediol, 6-ethyl-3-methyl-1,6- Octanediol, 1,2-dodecanediol, 1,10-dodecanediol, 1,12-dodecanediol, 2,4-diethyl-1,5-octanediol, 2,8,8-trimethyl-2,7-nonane Diol, 1,2-tetradecanediol, 1,14-tetradecanediol, 7,8-tetradecanediol, 1,2-pentadecanediol, 1,2-hexadecandiol, 1,16-hexadecandiol, 1,17-heptadecane Saturated diols or condensates thereof, such as diols, 1,2-octadecanediol, 1,12-octadecanediol, 1,2-eicosanediol, 1,2-docosanediol, 1,2-tetracosanediol;

2-Buten-1,4-diol, 3-butene-1,2-diol, 2-methylene-1,3-propanediol, 2-butin-1,4-diol, 5-hexene-1,2-diol , 3-Methyl-2-pentene-1,5-diol, 3-methylenepentane-1,5-diol, 1,5-hexadien-3,4-diol, 7-octene-1,2-diol, 2, 5-Diol-3-hexene-2,5-diol, 9-decene-1,2-diol, 2,6-dimethyl-7-octene-2,6-diol, 3,7-dimethyl-7-octene- 1,6-diol, 13-tetradecene-1,2-diol, 12-hydroxy-9-octadesenol, 2-pentin-1,4-diol, 3-hexine-2,5-diol, 4-methyl-2- Pentin-1,4-diol, 3-heptin-2,5-diol, 4-methyl-2-pentin-1,4-diol, 3,4-dimethyl-1-pentin-3,4-diol, 2, 5-Diol-3-hexin-2,5-diol, 5-decine-4,7-diol, 2,6-dimethyl-7-octin-2,6-diol, 3,6-dimethyl-4-octin- 3,6-diol, 2,3,6,7-tetramethyl-4-octin-3,6-diol, 2,4,7,9-tetramethyl-5-decine-4,7-diol, 2, 5,8,11-Tetramethyl-6-dodecin-5,8-diol, 3,3,6,6-tetraisopropyl-4-octin-1,8-diol, 5,10-diethyl-7-tetradecine- Unsaturated diols such as 6,9-diol;

1,2-Cyclopentanediol, 1,3-cyclopentanediol, 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2-cycloheptanediol, 2,3-norbornane Diol, 2,5-norbornandiol, 2,7-norbornandiol, 1,2-cyclooctanediol, 1,4-cyclooctanediol, 1,2-cyclodecanediol, 5-cyclooctene-1,2-diol , 1,5-decalindiol, limonene glycol, 1,2-terpenediol, 4,4'-bicyclohexanediol, 1,2-cyclododecanediol and other alicyclic diols;

Glycerin, 1,2,3-butanetriol, 1,2,4-butanetriol, 2-methyl-1,2,3-propanetriol, 1,2,3-pentanetriol, 1,2,4-pentanetriol , 1,3,5-pentantriol, 2,3,4-pentantriol, 2-methyl-2,3,4-butanetriol, trimethylolethane, 2,3,4-hexanetriol, 2-ethyl-1 , 2,3-Butantriol, Trimethylol Propane, 4-propyl-3,4,5-Heptanetriol, 2,4-Dimethyl-2,3,4-Pentantriol, Triethanolamine, Triisopropanolamine, etc. 3 Triol;

Ellisritol, pentaerythritol, 1,2,3,4-pentatetrol, 2,3,4,5-hexatetrol, 1,2,4,5-pentantetrol, 1,3,4,5-hexane Tetrol, diglycerin, sorbitan, N, N, N', N'-tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N', N'-tetrakis (hydroxyethyl) ethylenediamine and other tetrahydric alcohols;

Pentahydric alcohols such as adonitol, arabitol, xylitol, triglycerin;
Hexavalent alcohols such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, darcitol, talose, allose;

1-Methyl glyceryl ether, 2-Methyl glyceryl ether, 1-ethyl glyceryl ether, 2-ethyl glyceryl ether, 1-propyl glyceryl ether, 2-propyl glyceryl ether, 1-isopropyl glyceryl ether, 2-isopropyl glyceryl ether, 1- Butyl glyceryl ether, 2-butyl glyceryl ether, 1-isobutyl glyceryl ether, 2-isobutyl glyceryl ether, 1-pentyl glyceryl ether, 2-pentyl glyceryl ether, 2-hexyl glyceryl ether, 2-heptyl glyceryl ether, 2-octyl glyceryl Ether, 2- (2-ethylhexyl) glyceryl ether, 2-nonyl glyceryl ether, 2-decyl glyceryl ether, 1-undecyl glyceryl ether, 2-undecyl glyceryl ether, 1-dodecyl glyceryl ether, 2-dodecyl glyceryl ether, 1-Tridecyl glyceryl ether, 2-Tridecyl glyceryl ether, 1-Tetradecyl glyceryl ether, 2-Tetradecyl glyceryl ether, 1-Hexadecyl glyceryl ether, 2-Hexadecyl glyceryl ether, 1-Octadecyl glyceryl ether, 2- Octadecyl glyceryl ether, 1-branched octadecyl glyceryl ether, 2-branched octadecyl glyceryl ether, 1-eicosyl glyceryl ether, 2-eicosyl glyceryl ether, 1-allyl glyceryl ether, 2-allyl glyceryl ether, 1-undece Glycerin monoethers such as nyl glyceryl ether, 2-undecenyl glyceryl ether, 1-oleyl glyceryl ether, 2-oleyl glyceryl ether, 2-cyclohexyl glyceryl ether, 2-phenyl glyceryl ether;

N-substituted diethanolamines such as N-methyldiethanolamine, N-ethyldiethanolamine, N-propyldiethanolamine, N-isopropyldiethanolamine, N-butyldiethanolamine, N-cyclohexyldiethanolamine, N- (2-ethylhexyl) diethanolamine;

N-methyldiisopropanolamine, N-ethyldiisopropanolamine, N-propyldiisopropanolamine, N-isopropyldiisopropanolamine, N-butyldiisopropanolamine, N-cyclohexyldiisopropanolamine, N- (2-ethylhexyl) di N-substituted diisopropanolamines such as isopropanolamine;

3-Dimethylamino-1,2-propanediol, 3-diethylamino-1,2-propanediol, 3-dipropylamino-1,2-propanediol, 3-diisopropylamino-1,2-propanediol, 3- Examples thereof include N, N-di-substituted-3-amino-1,2-propanediols such as dibutylamino-1,2-propanediol.

Among these low molecular weight polyols, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,2-butanediol, 1,3-butanediol, 2,3-butanediol, 1 , 2-Pentanediol, 3-Methyl-1,3butanediol, 2-Ethyl-1,3-hexanediol, 2-Butyl-2-ethyl-1,3-Propanediol, 1,10-decanediol, glycerin , Triethanolamine, triisopropanolamine, erythritol, diglycerin, sorbitan, N, N, N', N'-tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N', N'-tetrakis (hydroxyethyl) Ethylenediamine, sorbitol, 1-methylglyceryl ether, 1-ethylglyceryl ether, 1-propyl glyceryl ether, 1-butyl glyceryl ether, 1-allyl glyceryl ether are preferable, and ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol and dipropylene Glycol, tripropylene glycol, 1,3-butanediol, 3-methyl-1,3 butanediol, glycerin, triethanolamine, diglycerin, sorbitan, N, N, N', N'-tetrakis (2-hydroxypropyl) ) Ethylenediamine, sorbitol and 1-allyl glyceryl ether are more preferable, and propylene glycol, dipropylene glycol, 1,3-butanediol, 3-methyl-1,3 butanediol, glycerin, sorbitol and 1-allyl glyceryl ether are more preferable. , Propylene glycol, 1,3-butanediol and glycerin are even more preferred.

The blending amount of the low molecular weight polyol is not limited as long as the effect of the present invention is exhibited, but the blending amount of the low molecular weight polyol is preferably more than 0.5 parts by mass with respect to 100 parts by mass of the component (A), and 1 mass by mass. It is more preferably more than 2 parts by mass, and most preferably more than 2 parts by mass. If the blending amount of the low molecular weight polyol is 0.5 parts by mass or less with respect to 100 parts by mass of the component (A), the effect of improving the antibacterial property due to the addition of the low molecular weight polyol may not be obtained.

Since the antibacterial effect of the present invention is enhanced, the component (E) is further selected from the group consisting of a nitrogen-containing nonionic surfactant, a nitrogen-containing amphoteric surfactant, a plant-derived extract, and a zinc compound. It is preferable to contain one kind or two or more kinds of compounds.

Examples of the nitrogen-containing nonionic surfactant include compounds represented by the following general formulas (7) to (13).

(In the formula, R ¹⁴ represents an alkyl group or an alkenyl group, R ¹⁵ represents an alkyl group, an alkenyl group or _{a group represented by − (CH 2} CH ₂ O) _e −H, and d and e represent 1 to 20 respectively. Represents the number of.)

(In the formula, R ¹⁶ represents an alkyl group or an alkenyl group, f, g and h each represent a number of 1 to 20, and i represents a number of 2 to 3.)

(In the formula, R ¹⁷ represents an alkyl group or an alkenyl group.)

(In the formula, R ¹⁸ represents an alkyl group or an alkenyl group, R ¹⁹ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group represented by ^{− (R 21} O) _k ^{−H, and R 20} and R ²¹ represents an alkylene group having 2 to 3 carbon atoms, and j and k each independently represent a number of 1 to 20.)

(In the formula, R ²² and R ²³ represent an ethylene group or a propylene group, and m and n represent independent numbers of 1 to 200, respectively. However, R ²² and R ²³ do not have the same group. )

(In the formula, R ²⁴ represents an alkyl group or an alkenyl group.)

(In the formula, R ²⁵ represents an alkyl group or an alkenyl group, and p represents a number of 2 or 3.)

In the general formula (7), R ¹⁴ represents an alkyl group or an alkenyl group, R ¹⁵ represents an alkyl group, an alkenyl group or _{a group represented by − (CH 2} CH ₂ O) _e −H, and d and e represent, respectively. Represents a number from 1 to 20. R ¹⁴ is preferably an alkyl group or an alkenyl group having 8 to 22 carbon atoms, and more preferably an alkyl group or an alkenyl group having 12 to 18 carbon atoms. Further, R ¹⁵ is preferably a group represented by − (CH ₂ CH ₂ O) _{e −H.} For d and e, the total value of d and e is preferably a number of 2 to 10, and more preferably a number of 2 to 4.

In the general formula (8), R ¹⁶ represents an alkyl group or an alkenyl group, f, g and h each represent a number of 1 to 20, and i represents a number of 2 to 3. R ¹⁶ is preferably an alkyl group or an alkenyl group having 8 to 22 carbon atoms, and more preferably an alkyl group or an alkenyl group having 12 to 18 carbon atoms. For f, g and h, the total value of f, g and h is preferably a number of 3 to 10, and more preferably a number of 3 to 5. Further, i is preferably a number of 3.

In the general formula (9), R ¹⁷ represents an alkyl group or an alkenyl group. R ¹⁷ is preferably an alkyl group or an alkenyl group having 8 to 22 carbon atoms, more preferably an alkyl group or an alkenyl group having 9 to 18 carbon atoms, and even more preferably an alkyl group or an alkenyl group having 10 to 14 carbon atoms.

In the general formula (10), R ¹⁸ represents an alkyl group or an alkenyl group, R ¹⁹ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group represented by ^{− (R 21} O) _{k −H, and R} ²⁰ and R ²¹ each represent an alkylene group having 2 to 3 carbon atoms, and j and k each independently represent a number of 1 to 20. R ¹⁸ is preferably an alkyl group or an alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or an alkenyl group having 9 to 17 carbon atoms, and even more preferably an alkyl group having 11 to 13 carbon atoms. Further, R ¹⁹ is preferably a hydrogen atom, a methyl group, or −CH ₂ CH ₂ OH, and more preferably a hydrogen atom or a methyl group. When R ¹⁹ is a hydrogen atom, the number of j is preferably 1 to 3, and more preferably R ²⁰ is an ethylene group and j is 1. When R ¹⁹ represents a methyl group, preferably R ²⁰ is an ethylene group, and more preferably R ²⁰ is j is 1 in ethylene group. When R ¹⁹ is −CH ₂ CH ₂ OH, ^{it is preferable that R 20} is an ethylene group and j is 1.

In the general formula (11), R ²² and R ²³ represent an ethylene group or a propylene group, and m and n represent independent numbers of 1 to 200, respectively. However, R ²² and R ²³ do not have the same group, and ^{it is preferable that R 22} is a propylene group and R ²³ is an ethylene group. Further, m is preferably a number of 7 to 25, more preferably a number of 10 to 15, and even more preferably a number of 11 to 13. Further, the value of n is preferably 10 to 200%, more preferably 20 to 150%, and even more preferably 50 to 100% with respect to the value of m.

In the general formula (12), R ²⁴ represents an alkyl group or an alkenyl group. R ²⁴ is preferably an alkyl group having 9 to 18 carbon atoms or an alkenyl group, more preferably an alkyl group having 10 to 16 carbon atoms, and even more preferably an alkyl group having 10 to 14 carbon atoms.

In the general formula (13), R ²⁵ represents an alkyl group or an alkenyl group, and p represents a number of 2 or 3. R ²⁵ is preferably an alkyl group or an alkenyl group having 8 to 17 carbon atoms, more preferably an alkyl group or an alkenyl group having 9 to 15 carbon atoms, and even more preferably an alkyl group having 9 to 13 carbon atoms. The number of p is preferably 3.

Among these nitrogen-containing nonionic surfactants, the compounds represented by the general formulas (7), (9), (10), (12) and (13) are preferable, and the general formulas (9) and (10) , (12) is more preferable, and the general formula (10) is most preferable.

The amount of the nitrogen-containing nonionic surfactant to be blended is not limited as long as the effect of the present invention is exhibited, but the blending amount of the nitrogen-containing nonionic surfactant is 0.5 to 500 parts by mass with respect to 100 parts by mass of the component (A). Preferably, 1 to 200 parts by mass is more preferable, and 2 to 50 parts by mass is most preferable. If the blending amount of the nitrogen-containing nonionic surfactant is less than 0.5 parts by mass with respect to 100 parts by mass of the component (A), the effect of improving the antibacterial property due to the addition of the nitrogen-containing nonionic surfactant may not be obtained. Yes, if it exceeds 500 parts by mass with respect to 100 parts by mass of the component (A), it may not be possible to obtain an improvement in antibacterial properties commensurate with the amount added.

Examples of the nitrogen-containing amphoteric surfactant include compounds represented by the following general formulas (14) to (19):

(R ²⁶ represents an alkyl group and q represents a number 1-3.)

(R ²⁷ represents an alkyl group or an alkenyl group, and r represents a number of 2 to 3.)

(R ²⁸ represents an alkyl group or an alkenyl group, and s represents a number of 2 to 3.)

(R ²⁹ represents an alkyl group or an alkenyl group.)

(R ³⁰ represents an alkyl group or an alkenyl group, and t represents a number of 2 to 3.)

(R ³¹ represents an alkyl group or an alkenyl group, and u represents a number of 2 to 3.)

In the general formula (14), R ²⁶ represents an alkyl group and q represents a number 1-3. R ²⁶ is preferably an alkyl group having 9 to 18 carbon atoms, more preferably an alkyl group having 10 to 16 carbon atoms, and even more preferably an alkyl group having 10 to 14 carbon atoms. Further, q is preferably a number of 1. A compound having q of 1 may be referred to as an alkylcarboxybetaine.

In the general formula (15), R ²⁷ represents an alkyl group or an alkenyl group having 7 to 21 carbon atoms, and r represents a number of 2 to 3. ^{R 27} is preferably an alkyl group or an alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or an alkenyl group having 9 to 15 carbon atoms, and even more preferably an alkyl group having 9 to 13 carbon atoms. Further, r is preferably a number of 3.

In the general formula (16), R ²⁸ represents an alkyl group or an alkenyl group, and s represents a number of 2 to 3. R ²⁸ is preferably an alkyl group or an alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or an alkenyl group having 9 to 15 carbon atoms, and even more preferably an alkyl group having 9 to 13 carbon atoms. Further, the number of s is preferably 3.

In the general formula (17), R ²⁹ is preferably an alkyl group or an alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or an alkenyl group having 9 to 15 carbon atoms, and further preferably an alkyl group having 9 to 13 carbon atoms. ..

In the general formula (18), R ³⁰ represents an alkyl group or an alkenyl group, and t represents a number of 2 to 3. R ³⁰ is preferably an alkyl group or an alkenyl group having 8 to 18 carbon atoms, more preferably an alkyl group or an alkenyl group having 10 to 16 carbon atoms, and even more preferably an alkyl group having 10 to 14 carbon atoms. Further, t is preferably a number of 3.

In the general formula (19), R ³¹ represents an alkyl group or an alkenyl group, and u represents a number of 2 to 3. ^{R 31} is preferably an alkyl group or an alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or an alkenyl group having 9 to 15 carbon atoms, and even more preferably an alkyl group having 9 to 13 carbon atoms. Further, u is preferably in the number of 3.

Among these nitrogen-containing amphoteric surfactants, the compounds represented by the general formulas (14), (15) and (16) are preferable, the general formulas (14) and (15) are more preferable, and the general formula (14) is more preferable. ) Is the most preferable.

The blending amount of the nitrogen-containing amphoteric surfactant is not limited as long as the effect of the present invention is exhibited, but the blending amount of the nitrogen-containing amphoteric surfactant is 0.5 to 500 parts by mass with respect to 100 parts by mass of the component (A). Preferably, 1 to 200 parts by mass is more preferable, and 2 to 50 parts by mass is most preferable. If the blending amount of the nitrogen-containing amphoteric tenside is less than 0.5 parts by mass with respect to 100 parts by mass of the component (A), the effect of improving the antibacterial property due to the addition of the nitrogen-containing amphoteric surfactant may not be obtained. Yes, if it exceeds 500 parts by mass with respect to 100 parts by mass of the component (A), it may not be possible to obtain an improvement in antibacterial property commensurate with the amount added.

In the present invention, the plant-derived extract refers to all plants, algae or fungi, or specific parts such as flowers, leaves, stems, fruits, bark, roots, seeds and resins, as they are, or by pressing, drying, crushing or fermenting. It is obtained by extracting with a solvent at room temperature or under heating after adding the above, and is soluble in water, ethanol, propylene glycol or fats and oils. Alternatively, the extract may be diluted, concentrated, or dried. Further, the essential oil may be obtained by using a steam distillation method, an extraction method, a chromatography method or the like.

The extraction solvent is usually used for extracting natural components, such as water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as ethylene glycol, propylene glycol, butylene glycol and glycerin; acetone and methyl ethyl ketone. Etc .; esters such as methyl acetate and ethyl acetate; ethers such as tetrahydrofuran, diethyl ether and polyethylene glycol; halogenated hydrocarbons such as dichloroethane and chloroform; aliphatics such as petroleum ether, n-hexane and cyclohexane. Examples thereof include hydrocarbons; aromatic hydrocarbons such as toluene; pyridines; sodium chloride solution and the like, and water, ethanol, propylene glycol and butylene glycol are particularly preferable.

Plants that can be used as plant-derived extracts include, for example, arch choke, almond, eye, Aisenhardia polystakia, eyebright, aonoryuzetsuran, aomoji, acacia concinna, acacia senegal, acacia senegal gum, acacia declins, red foxtail, etc. Akaharnile, Akayaziou, Agi, Agrimonia eupatoria, Akebii, Asagaokakarakusa, Azami, Ashi, Ashitaba, Ajugatsuru Kestonica, Azuki, Asunaro, Asparagus, Asparasas linearis, Acerola, Asenyaku, Asenyakunoki, Atlas Gace Sleiocarps, Avenastrigosa, Avocado, Ama, Amacha, Jiaogulan, Amadokoro, Amamo, Amiris balsamifera, American licorice, American licorice, American show, American carrot, Amomu aromaticum, Arakashi, Arcana, Arctium majus , Arctium minus, Arnica, Arnica camisonis, Alpinia officinalum, Alfalfa (also known as purple turmeric), Aloe vera, Anzanju, Anzu, Angelica, Antilis brunellaria, Amperopsis grosedentata, Ammaroku, Ikarisou, Izayoibara, Itadori, Italian Itosugi, Strawberry, Strawberry, Ichiyakuso, Ginkgo, Itlan, Inagomame, Ibukitranoo, Imosemiru, Irakusa, Iran Iran, Iris, Iris Parida, Iwabenkei, Iwamitsuba, Ingenmame, Fennel, Witania somnifera Utsubogusa, Udo, Umikuroumedoki, Ume, Uyaku, Uralkanzo, Uri, Urbarakutsuka, Urumusudavidiana, Uncariatomentosa, Unshuumikan, Agetsu, Eirantai, Edelweiss, Ezokogi, Ezosnake Strawberry, Ezomisohagi Ebine, Everyco, Elm, Elemi, Enju, Peas, Empitsbyaxin, Enmeisou, Oshuyomogi, Ouren, Oazami, Oomegasasou, Oezodenda, Okarasunoendo, Orchismakurata, Orchis maskula, Orchid, Oak (also known as European oak) , Turmeric, English oak, Jiaogulan, Obana salsbury, Obenimikan, Omitengyashi, Ominotokeisou, Omugi, All spice, Okazeri, Okura, Oshiroybana, Otaneninjin, Otogirisou, Onigeshi, Onisalvia, Onihamadaikon, Ononis, Opuntia streptacantha, Opuntia tuna, Dutch buckthorn, Dutch shakyak, Olive, Origanum gentian, Ortoshihon stamineus, Olmenis , Orobankerapum, Gardenia Tahitensis, Carnation, Kayasenegalensis, Cacao, Cucumber, Cassia, Cashew nut, Cascara Sagrada, Cascara buckthorn, Kappaficus alvarez, Cattleya, Canada Hydrastis, Canaryanoki, Kaninabara, Kanokosou , Cub, Gama (Gentiana), Cumin (also known as chamomile), Kamimebouki, Kayupte, Karakusakeman, Karasumugi, Karasumugiwara, Karatouki, Galana, Garikabara, Califlower, Karin, Karuna (also known as Gyoryumodoki), Garsina Cambodia Inchinko), Kanzo, Kantenitabi, Kistrawberry, Kiwi, Kikarasuuri, Kikunigana, Kigeria Africana, Kidachialoe, Kidachihakka, Kinanoki, Kinoa, Kihada (also known as Oubaku), Kibanasushiro, Kibananohauchiwamame, Kibi, Gymnema , Cabbage, Caraway, Cucumber (also known as Cucumber), Kyoou, Gyoryu, Gyoryubai, Kiraya, Kiri, Ginbaika (also known as Suikazura), Gua, Guava, Quinceseed, Quercus Alba, Kukuinoki, Kuco, Kusanoou, Kuzu, Kusunoki Tokeisou, Kuchinashi, Verbena, Kumazasa, Verbena, Kumanogiku, Cumin, Clameria terriandra, Clara, Granberry, Chrismum maritimum, Grindeli alobsta, Clintonia borealis, Kurumabasou, Walnut, Grapefruit, Crematis, Black mustard, Black mustard, Black mustard , Globe, Crofusaguri, Chromigwa, Cumin, Keiketto, Kay (also known as cinnamon), Geumurbanum, Geumribare, Cape Aloe, Keshi, Gekkabidin, Baythorn, Getto, Chemiyamakouzorina, Gentiana, Gentiana prostrata, Gennoshoko, Kemponashi Baythorn, Kousuigaya, Cucumber, Kohone, Coffee tree, Koganebana, Kokusina indica, Kokutan, Cucumberia officinalis , Kokemomo, Coco palm, Gosho strawberry, Kosho, Koshiro no Sendangusa, Kochinir cactus, Kocho sekoku, Kocho orchid, Konara, Kohakobe, Gobo, Sesame, Wheat, Rice, Koranoki, Coriander, Coleus, Coleus barbatus, Gorenshi, Koroha (Also known as comfrey), Comfrey micransum, sisal asa, cycin, cyperus esculentas, cypress, medlar, south rare involcrata, saxima button dull, cherry, cherry bakanboku, pomegranate, sugar cane, sugar cane, sugar cane, sasanka, sassa , Sabonsou, Sarasouju, Salix Nigra, Salsberg, Sanguinaria canadensis, Sanzashi, Sanshikisumire, Sanshichininjin, Sanshuyu, Sansho, Sanpens, Ciateamedularis, Cyanochis arakunoidea, Shea butternoki, Shiozakisou Cystorose (also known as Labdanum), Sistus monsperiensis, Sistus sladanifers, Perilla, Comfrey, Shinanoki, Shibamugi, Gypterix odorata, Siberian fir, Simulva, Shimisifugadafurika, Shimotsukesou, Potato, Shakuyaku, Jasmine, Comfrey, Janome Erica, Shukusha, Juzudama, Shukkon Kasumi Sou, Junipels Mexicana, Junsai, Ginger, Shozuku (also known as Cardamom), Shobu, Dandelion, Shirakaba, Silane, Rogarashi, Shirobana Indosokei, Shirobana Rupin Synsepalm durcificum, symbidium, symprocoslas semosa, sweet acacia, watermelon, watermelon, scabiosa albensis, sugina, scutellaria galericrata, stevia, strobe pine, spiny bamboo, spirulina platensis, spirulina maxima, sperihiyu, Spelled wheat, Suminomizakura, Sumilux Aristolocia ehoria, Akane, Akane, Akamatsu, Astragalus membranaceus, Astragalus membranaceus, Acorn edulis, Acorn edulis, Acorn medlar, Acorn medlar, Acorn medlar Comfrey, Comfrey, Comfrey, Pepper, Comfrey, Comfrey, Dandelion, Dandelion, Comfrey Utsuge, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium, Geranium , Ceylon, Geranium, Celsidium Floridam, Cerus Grandiflorus, Celoli, Senkyu, Cecil Oak, Sedum Purpleum, Zenia Oy, Ceylon Nikkei, Sage, Secropia of Tsushihoria, Sequoia Osugi, Cecil Oak Sentifolia rose, centipeda kunningami, senninkoku, sempukuka, senburi, sojutsu, souhakuhi, sou palmetto, sokei, buckwheat, solanumuricocarpum, daiuikyo, daikon, daisanchiku, soybean, taiso, daidai, taitsuriougi, thyme, tyme , Takasaburo, Tachijakousou, Tachibana, Tabunoki, Tabebuia Aberanedae, Tamasaki Tsuzurafuji, Damask rose, Onion, Damiana, Tarragon, Tanjin, Tamborissa trichophylla, Chigaya, Cha (brown), Chabotokeiso Geranium, Chili Atmentosa, Tsukushimenamomi Tsubaki, Tarragon, Tarragon, Turdokudami, Tsurureishi, Tea Tree, Dioscorea Composita, Dioscorea virosa, Dioscorea Mexicana, Teuchigurumi, Tecoma Clearis, Tetsuzainoki, Duke, Duboisia Chi, Terminaria, Tencha, German Ayame, German Tohi, Tougashi, Togarashi, Touki, Tokinsenka, Tounin, Tounezumimochi, Tohi, Corn, Corn Silk, Torowsou, Tokusa, Dokudami, Dokuninjin, Toshishi (also known as Mamedaoshi) Tomato, Trigonella foenum, Tormentilla, Tororoaoimodoki, Nagabagishigishi, Nagiikada, Nas, Nazuna, Natamame, Natsushirogiku, Natsubodaige, Natsume, Natsumeyashi, Nankyosou, Nanbanai, Nanbanksafuji, Nioisumi , Nutmeg, Nigera Sachiba, Nyukouju, Niranegi, Carrot, Carrot, Ninfaea Alba, Nenashikazura, Neubara, Nozenharen, Nojisumire, No Rose, Noborogiku, Pineapple, Hibiscus, Pinus pumila, Baobab, Bakuhosia citriodora, Bakumondou, Bakopamonniera, Hagoromogusa, Hass, Parsley, Pachori, Hazelnut, Baccaris genisteroides, Passiflora Arata, Hatomugi, Banana, Hanahakka , Vanilla, Vanilla Tahitensis, Hanesenna, Papaya, Pafio Pedirum Maudiae, Havelrea Rodopensis, Hamanas, Hamamelis, Hayatouri, Rose, Parietaria, Harienju, Harpagofitum, Palmarosa, Barosmabetsurina, Banukon , Hiougi, Hikiokoshi, Bisnagabella, Bitter Almond, Bitter Orange, Hydrastis canadensis, Hinagiku, Hinageshi, Binan Kazura, Pinus Heda, Hinoki, Hibamata, Hihiragigiku, Hipophaeram Neudes, Himawari, Himekouji Barril, Himefuuro, Byakudan, Hiyokome, Hiramame, Hireharisou, Biroudoaoi, Pyrocarps pennachihorius, Biwa, Binrou, Fafia panicrata, Fusenkazura, Pueraria milifica, Ferula galvanifurua, Fukitanpopo, Bunchflowered duck Fuji Utsugi, Fusanus spicatus, Petit Glen, Petit Copetalum Oracoides, Bussouge, Butcher Bloom, Pterocarps Marspium, Grape, Futomomo, Safflower, Zanthoxylum armacesis, Tilia cordata, Fuyumusina tsukusatake, Fragaria tyroensis, Brazilian nuts Noki, French Kaigan Show, French Lavender, Plantago Afra, Plantago Obata, Plantagopsilium, Primula Sikimensis, Prun, Prunus Africana, Prunus Serotina, Plumeria, Plectrantus barbatas, Brecia hyacinthina, Propolis, Bay, Hayflower, Hazelnut, Pecan, Vetiber, Hechima, Pennyroyal Mint, Beninoki, Benibana, Benibana Assembly, Pepo Pumpkin, Hera Obako, Pelargonium Capitatum, Helichrysum Arenalium, Helichrysum Angstihorium, Helichrysum Italicum Peltoholm da silatis, peruvian balsam, bergamot, velberis aquihorium, veronica ophicinaris, henna, hazelnut, hoki Gi, Bowshuboku, Bowshunka, Hosenka, Houraishida, Horensou, Hawkweed, Hoonoki, Hokubeifuurosou, Bokoaprouasensis, Boswellia serata, Hosobasenna, Hosobabarengiku, Bodaiju, Button, Hop, Poterium officinale, Hohoba , Bold, Ponkan, Macademia, Magnolia Officinalis, Magnolia Bionji, Magwa, Magojakushi, Masaki, Madake, Matsu, Matsurika, Matecha, Madonna Lily, Mayorana, Maria Azami, Malpigia Grabra, Marmero, Maronie, Mango, Mango Manshu Akajika, Manshu Akamatsu, Manjugiku, Mandarin Orange, Mandrake, Mishima Psycho, Mizuhakka, Mizu Lemon, Michiyanagi, Mitsugashiwa, Mitra Carpas Caber, Mimosa Tenui Flora, Mircaria Dubia, Milra (also known as Motsuyakuju) , Mirobaran, Mukuroji, Murasaki, Murasakikibu, Murasaki Senburi, Murasaki Barengiku, Murayakoenji, Mebouki, Mematsuyoigusa, Melia Azajirakuta, Melissa (also known as Kousuihakka), Merirot, Melosria, Melon, Menta albensis , Moscatabara, Moss Bean, Motsuyakuju, Momo, Momotamana, Yakumosou, Yagurumagiku, Yashabushi, Yachiyanagi, Yanagihakka, Yanagiran, Yamagwa, Yamazakura, Yamanoimo, Yamayomogi, Yugao, Yukari , Yuzu, Yusoboku, Yucha, Yukkagrauka, Yukkashijigera, Yuri, Yosutsurkinbai, Yoshuhozuki, Yoshuyamagobo, European goldenrod, European raspberry, European greens, European black litchi, European white birch, European beech, European mannengusa, Europe Fir, yomogi, yomogigiku, lychee (also known as lychee), lychee, lime, limegi, lilac, radiata pine, latania, laccasei, ranunculus vicaria, lavandula hybrida, rafuma, lavender, lalix europaea, larea divaricata, larea mexicana , Rambutan, Lychee, Lychee Samnium Calcarum, Lithosea glutinosa, Ryugan, Lirio Sumao Bataki, apple, Louis Boss, Lupinus bucarnosus, Lubus virosus, Lumpuyan, Borage, Rurihiensou, Respedeza, Resedarteora, Lettuce, Redama, Redam pulsetre, Lebanon sugi, Levisticum officinale, Lemon, Lemongrass, Plants such as wood, rosemary, low bush blueberry, Roman chamomile, laurel (also known as laurel), logwood, Robusta coffee tree, wild thyme, wasabi, wasabi daikon, wasabi tree, cotton squirrel, cotton wisteria, walteria indica, and crackle.

Ascofilm Nodosum, Aname, Oukimo, Okinawamozuku, Gigarchina Stellata, Kugermaniera Girata, Sargassum Filipendura, Sargassum Fushiform, Sargassum Mutikam, Sfaceraria Scoparia, Durbilea Antartica, Padina Pavonica, Himantaria elongata, fucas seratsus, pervecia canaliculata, macrocystis spirulina, mitsushikonbu, laminaria ochlorosquid, laminaria chlorella, laminaria diguitarta, laminaria hiperbolea, wakame seaweed, asparagopsis algae , Katamen Kirinsai, Geridium Curtilagineum, Saimi, Shimatengusa, Darus, Chinorimo, Tochaka, Porphyridium cruentum, Marubachishimakuronori, Lithosamnium Corarioides, Anaaosa, Chlorella emersoni, Chlorella pyrenoidosa, Dunariella salina , Duna Liera Badawill, Hira Aonori, Spirulina Platensis, Spirulina Maxima, Haslea Ostrearia, Deresseria sanguinea, Pikea Robusta, Pruurocrisis Cartere, Hematococcus bulbiaris, Orchid Algae, Condor Scrisps, Coral, Sea Whip, Red Algae such as algae;

Examples include lichens and hyphae such as Ebernia full fracea, Oakmoss, Usnia barbata, Cynomorium cocci, Kabaanatake, Shiitake, Ningyotake, Himematsutake, Fuyumusinatsukusatake, Kabaanatake, Choreimaitake, and winter worm summer grass.

The blending amount of the plant-derived extract is not limited as long as the effect of the present invention is exhibited, but the blending amount of the plant-derived extract is preferably 0.1 to 1000 parts by mass with respect to 100 parts by mass of the component (A), and is 5 to 200 parts by mass. Parts are more preferable, and 1 to 100 parts by mass are most preferable. If the blending amount of the plant-derived extract is less than 0.1 parts by mass with respect to 100 parts by mass of the component (A), the effect of improving the antibacterial property due to the addition of the plant-derived extract may not be obtained, and the component (A) If it exceeds 1000 parts by mass with respect to 100 parts by mass, it may not be possible to obtain an improvement in antibacterial properties commensurate with the amount added.

Examples of zinc compounds include zinc acetate, zinc laurate, zinc myristate, zinc palmitate, zinc ricinoleate, zinc undesylene, zinc aspartate, zinc acetylmethionine, zinc gluconate, zinc citrate, and polypyrrolidone carboxylic acid. Organic acid zinc salts such as zinc and zinc picolinate; zinc sulfonates such as zinc p-phenol sulfonate, zinc phosphate esters such as zinc ascorbyl phosphate, sodium cetyl phosphate, and DNA zinc; zinc complexes such as zinc pyrithione. Zinc-bearing zeolite such as (silver / zinc / ammonium) zeolite, silicic acid (ammonium / silver / zinc / aluminum); aluminum hydroxide such as aluminum oxide / zinc, aluminum oxide / zinc / cerium, aluminum oxide / zinc / iron Bake products such as: Zinc sulfate, Zinc sulfide, Zinc chloride, Zinc bromide, Zinc nitrate, Zinc ammonium chloride, Zinc aluminum sulfate, Zinc potassium sulfate, Zinc iodide, Basic zinc carbonate and other inorganic zinc salts; / Carbonate) (Mg / Al / Zinc), zinc oxide and the like can be mentioned. Among these, a compound that easily dissolves in water to form zinc ions is preferable, the solubility in 100 g of water at 20 ° C. is preferably 5 g or more, and the solubility is more preferably 10 g or more. Examples of such zinc compounds include zinc sulfate, zinc chloride, zinc gluconate, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, potassium zinc sulfate, zinc iodide and the like.

The blending amount of the zinc compound is not limited as long as the effect of the present invention is exhibited, but the blending amount of the zinc compound is preferably 0.02 to 10 parts by mass with respect to 100 parts by mass of the component (A), and is 0.05 to 5 parts by mass. Parts are more preferable, and 0.1 to 2 parts by mass is most preferable. If the blending amount of the zinc compound is less than 0.02 parts by mass with respect to 100 parts by mass of the component (A), the effect of improving the antibacterial property due to the addition of the zinc compound may not be obtained, and the effect of improving the antibacterial property due to the addition of the zinc compound may not be obtained. If it exceeds 10 parts by mass with respect to the part, the improvement of antibacterial property corresponding to the addition amount may not be obtained.

The mode of use of the antibacterial composition of the present invention is not particularly limited, and is used in the same manner as known antibacterial agents, bactericidal agents, disinfectants, and antifungal agents for the purposes of antibacterial, bactericidal, disinfectant, antifungal, etc. be able to. For example, a method of spraying on an object to be subjected to antibacterial treatment, a method of applying, a method of impregnating the object, a method of immersing the object, and the like, which are usually adopted, can be used as they are. In addition, the products to which the antibacterial composition of the present invention is used include medical instruments, medical cleaning agents for disinfecting and cleaning affected areas, household cleaning agents for sterilizing and cleaning dishes, and food industry. Examples include cleaning agents, lubricants for container transfer conveyors, food packaging films, fibers, synthetic resins, wood, antibacterial agents for antibacterial processing of daily necessities, cosmetics, sheet-like products for skin, etc., and have low skin irritation. Since it has high antibacterial properties, it can be particularly suitably used for cosmetics and skin sheet-like products.

Cosmetics to which the antibacterial composition of the present invention can be preferably used include makeup agents such as foundations, body powders, lipsticks, eye liners, eye shadows, and mascara; lotions, packs, emulsions, moisturizing gels, moisturizing creams, and whitening agents. Cream, anti-wrinkle cream, facial cleanser, cleansing gel, cleansing cream, hand soap, body shampoo, body lotion, body cream, shaving soap, shaving cream, after shave lotion, bathing agent, sunscreen agent, antiperspirant / body deodorant, etc. Skin care agents; shampoos, conditioners, conditioners, hair treatments, hair color treatments, hair sprays, hair mousses, hair tonics and other hair care agents.

In cosmetics in which the antibacterial composition of the present invention is used, surfactants other than the nitrogen-containing nonionic surfactant and the nitrogen-containing amphoteric surfactant usually used for facial cleansers (hereinafter, "other interfaces"). Activator ") may be used. Examples of other surfactants include anionic surfactants, cationic surfactants, nitrogen-free nonionic surfactants and the like. Among these, it is particularly preferable to use an anionic surfactant or a nitrogen-free nonionic surfactant as the cleaning agent of the present invention.

Examples of the anionic surfactant include higher fatty acid salts, higher alcohol sulfates, sulfated olefin salts, higher alkyl sulfonates, α-olefin sulfonates, sulfated fatty acid salts, and sulfonated fatty acid salts. Phosylate acid ester salt, fatty acid ester sulfate ester salt, glyceride sulfate ester salt, fatty acid ester sulfonate salt, α-sulfo fatty acid methyl ester salt, polyoxyalkylene alkyl ether sulfate ester salt, polyoxyalkylene alkyl phenyl ether sulfate ester salt , Polyoxyalkylene alkyl ether carboxylate, acylated peptide, fatty acid alkanolamide or sulfate ester salt of its alkylene oxide adduct, sulfosuccinic acid ester salt, alkylbenzene sulfonate, alkylnaphthalene sulfonate, alkylbenzoimidazole sulfonic acid Salt, polyoxyalkylene sulfosuccinate, salt of N-acyl-N-methyltaurine, N-acylglutamic acid or salt thereof, acyloxyethane sulfonate, alkoxyethane sulfonate, N-acyl-β-alanine or salt thereof , N-acyl-N-carboxyethyl taurine or a salt thereof, N-acyl-N-carboxymethylglycine or a salt thereof, acyl lactate, N-acylsulfosin salt, alkyl or alkenylaminocarboxymethylsulfate and the like. .. Examples of the counter ion of the salt of such an anionic surfactant include alkali metal ions such as lithium, sodium and potassium; alkaline earth metal ions such as calcium and magnesium; ammonium; monoethanolammonium, diethanolammonium and triethanolammonium. , Monoisopropanol ammonium, diisopropanol ammonium, organic ammonium such as triisopropanol ammonium and the like.

As the higher fatty acid salt, a salt of a fatty acid having 12 to 18 carbon atoms is preferable, and a coconut oil fatty acid salt, a dodecanoate, a tetradecanoate, a hexadecanoate, and an oleate salt are more preferable. Similarly, as the higher alkyl sulfate ester salt, an alkyl having 10 to 18 carbon atoms is preferable, and an alkyl having 12 to 16 carbon atoms is more preferable. The polyoxyethylene alkyl ether sulfate ester salt preferably has an alkyl having 10 to 18 carbon atoms, and more preferably 12 to 16 carbon atoms. The average degree of polymerization of the polyoxyethylene groups is preferably 1 to 12, more preferably 2 to 10, and even more preferably 3 to 8.

Among these anionic surfactants, higher fatty acid salt, higher alkyl sulfate ester salt, α-sulfo fatty acid methyl ester salt, higher alcohol sulfate ester salt, polyoxyethylene alkyl ether because they are less irritating to the skin and the like. Sulfate ester salt, polyoxyethylene sulfosuccinic acid alkyl ester salt, and monoalkyl phosphate ester salt are preferable, and higher fatty acid salt, higher alkyl sulfate ester salt, and polyoxyethylene alkyl ether sulfate ester salt are more preferable. For the same reason, sodium ion, potassium ion, ammonium, and triisopropanol ammonium are preferable as the counter ion of the salt of the anionic surfactant.

Examples of the nitrogen-free nonionic surfactant that can be preferably used in combination with the antibacterial composition of the present invention include polyoxyalkylene alkyl ether, polyoxyalkylene alkenyl ether, and polyoxyethylene polyoxypropylene alkyl ether. The addition form of ethylene oxide and propylene oxide may be random or block), polyethylene glycol propylene oxide adduct, polypropylene glycol ethylene oxide adduct, glycerin fatty acid ester or its ethylene oxide adduct, sorbitan fatty acid ester, poly. Examples thereof include oxyethylene sorbitan fatty acid ester, alkyl polyglucoside, sucrose fatty acid ester, alkyl (poly) glycerin ether, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, and fatty acid methyl ester ethoxylate.

Among such nitrogen-free nonionic surfactants, polyoxyethylene alkyl ether is preferable, and polyoxyethylene (the average number of moles of ethylene oxide added is preferably 4 to 18) alkyl (preferably 12 to 16 carbon atoms). Ether is more preferred. The above-mentioned surfactant can also be used in the cosmetic of the present invention.

In addition to the above-mentioned surfactant component, the cosmetic of the present invention has other components, such as silicone oil, thickener, oil, powder (pigment, pigment, resin), as long as the object of the present invention is not impaired. , Other antibacterial agents, fragrances, moisturizers, physiologically active ingredients, salts, solvents, antioxidants, chelating agents, pearlizing agents, neutralizing agents, pH adjusters, enzymes and other ingredients can be appropriately blended.

Examples of the thickener include dimethyldiallylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer, cellulose or its derivative, keratin and collagen or their derivatives, calcium alginate, pullulan, agar. , Gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, arabic gum, crystalline cellulose, arabinogalactan, karaya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, β-glucan, gellan gum , Dextran and the like.

Examples of the oil agent include volatile and non-volatile hydrocarbons, higher alcohols, medium- to high-chain fatty acids and their esters, fats and oils, etc., which are usually used in cosmetics, and may be liquid, paste, or solid at room temperature. However, a liquid having excellent handling is preferable. Examples of the oil agent include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol and octyldodecanol, fatty acids such as isostearic acid, undecylene acid and oleic acid, myristyl myristate, hexyl laurate and oleic acid. Esters such as decyl, isopropyl myristate, hexyldecyl dimethyloctanoate, glycerin monostearate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, hydrocarbons such as liquid paraffin, vaseline, squalane, lanolin, reduction Examples thereof include waxes such as lanolin and carnauba wax, mink oil, coconut oil, palm oil, palm kernel oil, camellia oil, sesame oil, castor oil, and fats and oils such as oleic acid.

Examples of the powder include pigments such as Red No. 201, Yellow No. 4, Blue No. 1 and Black No. 401, Lake Pigments such as Yellow No. 4 Al Lake and Yellow No. 203 Ba Lake, Nylon Powder, Silk Powder and Silicone Powder. , Cellulose powder, silicone elastomer spherical powder, polymer such as polyethylene powder, colored pigments such as yellow iron oxide, red iron oxide, chromium oxide, carbon black, ultramarine blue, dark blue, white pigments such as zinc oxide and titanium oxide, talc , Mica, serisite, kaolin and other extender pigments, mica titanium and other pearl pigments, barium sulfate, calcium carbonate, magnesium carbonate, magnesium silicate and other metal salts, silica, alumina and other inorganic powders, bentonite, smectite, boron nitride And so on. The shape of these powders (spherical, rod-shaped, needle-shaped, plate-shaped, indefinite-shaped, fluff-shaped, spindle-shaped, etc.) is not particularly limited.

These powders are subjected to conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, and poly. The surface may be treated in advance by acrylic acid treatment, metal soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment or the like.

Examples of other antibacterial agents include paraben-based antibacterial agents such as methylparaben and ethylparaben; imidazole-based antibacterial agents such as thiabendazole and methylpriventol 2-benzimidazolylcarbamate; and carvanilide-based agents such as trichlorocarbanilide and cloflucarban. Antibacterial agents; thiazole-based antibacterial agents such as benzothiazole; triazine-based antibacterial agents such as debuconazole and cabinone; biguanide-based antibacterial agents such as chlorhexidine hydrochloride and polyhexamethylene biguanide. Should be used with caution in consideration of irritation to the human body.

Examples of the moisturizing agent include diethylene glycol monoethyl ether, deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, biopolymers such as hydrolyzed eggshell membrane, amino acids, sodium lactate, and the like. Examples include urea, sodium pyrrolidone carboxylate, betaine, whey and the like.

Examples of the solvent include purified water, ethanol, light liquid isoparaffin, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, next-generation chlorofluorocarbon and the like.

As skin sheet-like products to which the antibacterial composition of the present invention can be preferably used, wet tissues, wet wipers, hand wipes, body cleaning sheets, wipes, nursing wipers, face masks, sweat wipe sheets, body sheets, toilet seats Examples include cleaners. A skin sheet-like product is a sheet-like fiber impregnated with a liquid containing water as a main component and is applied to the skin. Although the toilet seat cleaner does not come into direct contact with the skin, it is included in the skin sheet-like product because the skin comes into contact with the toilet seat immediately after using the toilet seat cleaner.

Examples of the sheet-like fiber of the sheet-like product for skin of the present invention include cellulose fiber, rayon, vinylon, polyester, acrylic, nylon, etc., and since they have high strength and excellent water absorption, cellulose fiber, rayon, etc. Rayon is preferred, and cellulose fibers are even more preferred. The shape of the sheet may be any of non-woven fabric, woven cloth, paper, sponge and the like, but non-woven fabric is preferable because the fibers are less likely to come off and the water absorption is excellent. The amount of water in the liquid impregnated in the skin sheet-like product of the present invention is preferably 50% by mass or more, and more preferably 70% by mass or more from the viewpoint of cleanliness and dryness.

When the skin sheet-like product of the present invention is used, the bacteria can be quickly sterilized without irritating the skin, and the sterilizing effect is maintained for a long time.

Hereinafter, the present invention will be specifically described with reference to Examples. In the following examples and the like, "%" and "ppm" are based on mass unless otherwise specified.

Using the following compounds, the antibacterial compositions of Examples 1 to 13 and Comparative Examples 1 to 18 were prepared in the blending ratios (parts by mass) of Tables 1 and 2 below.
A1: 1,2-octanediol A2: 1,2-hexanediol A3: 1- (2-ethylhexyl) gluceryl ether A4: 1-hexyl gluceryl ether A5: 1-cyclohexyl gluceryl ether B1: General formula (3) ), R ³ is a heptyl group, R ⁴ and R ⁵ are methyl groups, X is a chlorine atom, and a is 2. In the general formula (3), R ³ is a nonyl group, and R ⁴ and R ⁵ are. Methyl group, X is a chlorine atom, a is 2, compound B3: In general formula (4), R ⁶ is a heptyl group, R ⁷ and R ⁸ are methyl groups, Z is a chlorine atom, and b is 2. : In the general formula (4), R ⁶ is a nonyl group, R ⁷ and R ⁸ are a methyl group, Z is a chlorine atom, and b is a compound B5: In the general formula (5), R ⁹ is a heptyl group and R. ^{Compound B6 in which 10} and R ¹¹ are hydrogen atoms, R ¹² is a methyl group, Q is a chlorine atom, and c is 1. In general formula (5), R ⁹ is a nonyl group, R ¹⁰ is a hydrogen atom, and R ¹¹ is general. A compound represented by the formula (6) in which R ¹³ is a nonyl group, R ¹² is a methyl group, Q is a chlorine atom, and c is 1.

C1: Ethylenediaminetetraacetic acid disodium salt C2: Sodium citrate D1: Propylene glycol D2: 1,3-butanediol D3: Glycerin E1: Palm oil diethanolamide E2: In the general formula (14), R ²⁶ is a dodecyl group and q. Compound F1: Polyoxyethylene (20) sorbitane monooleate F2: Polyoxyethylene (20) Lauryl ether F3: Oleyl alcohol

[Evaluation as a sheet-like product for skin]
100 parts by mass of the antibacterial composition of Examples 1 to 13 or Comparative Examples 1 to 18 is impregnated in 50 parts by mass of a natural pulp-based non-woven fabric (manufactured by Fujix Co., Ltd., product name: Fuji Cooking Paper M (thick mouth) 275 x 240 mm). Then, test pieces of Examples 14 to 26 or Comparative Examples 19 to 38 were prepared.

[Antibacterial test]
<Aspergillus niger>
In accordance with JIS L1902 (antibacterial test method and antibacterial effect of textile products ^{), 10 mL of Sabouraud agar medium (bacterial concentration 2.3 x 10 6} pieces / mL) containing black-and-white mold was dispensed into a sterilized petri dish and flat plate. As a medium, a test piece cut into a length of 20 mm and a width of 20 mm was placed on this flat medium, cultured at 25 ° C. for 7 days, and then visually observed, and the antibacterial property was evaluated according to the following criteria. The results are shown in Tables 3 and 4.
⊚: Growth inhibition zone (halo-) is formed around the test piece and has high antibacterial property. ○: Growth inhibition zone is not formed, but no bacterial growth is observed on the test piece, and antibacterial property is slightly high. X: Bacteria grow on the test piece and have low antibacterial properties.

<Pseudomonas aeruginosa, Escherichia coli>
Instead of Sabouraud agar medium containing Aspergillus niger, ordinary agar medium containing Aspergillus niger (bacterial concentration 3.7 × 10 ⁶ cells / mL) or ordinary agar medium containing Escherichia coli (bacterial concentration 1.8 × 10) ⁶ cells / mL) was used, and the same operation as in the case of Aspergillus niger was performed except that the cells were cultured at 37 ° C. for 24 hours, and the same criteria as in the case of Aspergillus niger were used to evaluate the antibacterial property. The results are shown in Tables 3 and 4.

<Candida>
Instead of Sabouraud agar medium containing Aspergillus niger, Candida agar medium containing Candida (bacterial concentration 1.4 × 10 ⁶ cells / mL) was used, and the cells of Aspergillus niger were used except for culturing at 37 ° C. for 24 hours. The same operation as in the case was performed, and the operation was performed according to the same criteria as in the case of Aspergillus niger, and the antibacterial property was evaluated. The results are shown in Tables 3 and 4.

[Bactericidal test]
0.5 mL of physiological saline containing Staphylococcus aureus (number of bacteria 2.6 × 10 ⁶ cells / mL) was applied to a sterile slide glass, and after 10 minutes, the slide glass was wiped off with a test piece. After 5 minutes, in order to wash out the residual bacteria on the slide glass, 10 mL of the slide glass and polyoxyethylene (20) sorbitan monooleate in 0.2% physiological saline was placed in a sterile petri dish and stirred well. .. 0.1 mL of this washing solution was smeared on 10 g of ordinary agar medium, cultured at 37 ° C. for 24 hours, the number of bacteria was measured, and the sterilization property was evaluated according to the following criteria. The results are shown in Tables 5 and 6.
⊚: The number of bacteria is less than 10, and the sterilizing property is excellent.
○: number of bacteria is 10 to 10 ^2, excellent slightly disinfectant.
Δ: The number of bacteria is 10 ² to 10 ³ , and the sterilizing property is slightly inferior.
×: it is the number of bacteria 10 ³ or more, poor disinfectant.

[Sterilization sustainability test]
The sterilized slide glass was wiped off with a test piece, left at 25 ° C. for 24 hours, and then 0.1 mL of physiological saline containing Staphylococcus aureus (number of bacteria 4.9 × 10 ⁵ cells / mL) was applied. After 10 minutes, in order to wash out the residual bacteria on the slide glass, put 10 mL of this slide glass and polyoxyethylene (20) sorbitan monooleate in a 0.2% physiological saline solution in a sterile petri dish and stir well. , M0.1 mL of this washing solution, which was measured for the number of bacteria, was smeared on 10 g of ordinary agar medium, cultured at 37 ° C. for 24 hours, then the number of bacteria was measured, and the sustainability of sterilization was evaluated according to the following criteria. The results are shown in Tables 5 and 6.
⊚: The number of bacteria is less than 10, and the sterilization is excellent in sustainability.
○: number of bacteria is 10 to 10 ^2, excellent slightly sustainability of eradication.
Δ: The number of bacteria is 10 ² to 10 ³ , and the sustainability of sterilization is slightly inferior.
×: it is the number of bacteria 10 ³ or more, poor persistence of sterilization.

[Irritation test]
The inside of the forearm of the panelist was contacted with the test piece twice a day for 5 minutes for 5 days, and the presence or absence of erythema on the contact portion was examined. Tables 5 and 6 show the number of panelists with erythema. The number of panelists is 20 each, and the larger the number of panelists with erythema, the higher the irritation.

[Evaluation as a lotion]
The antibacterial compositions of Examples 10 to 11 and Comparative Examples 15 to 16 were used to evaluate the feeling of use as a lotion. After washing the face, 20 female panelists were asked to apply the antibacterial composition of Examples 10 to 11 or Comparative Examples 15 to 16 to the face as a lotion, and the number of panelists who felt discomfort in the applied portion was counted. The results are shown in Table 7. It should be noted that the larger the number of panelists who felt discomfort, the more irritation the skin had and the worse the feeling of use.

Claims (9)

The component (A) which is at least one diol compound selected from the group consisting of the compound represented by the following general formula (1) and the compound represented by the following general formula (2), and the following general formula (3). ) - (5) at least one cationic compound der selected from the group consisting of compounds represented by Ru (B) antibacterial compositions containing the ingredients.

(In the formula, R ¹ represents an alkyl group having 4 to 8 carbon atoms.)

(In the formula, R ² represents an alkyl group having 5 to 10 carbon atoms, a cycloalkyl group having 6 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, or an aralkyl group having 7 to 10 carbon atoms.)

(In the formula, R ³ represents an alkyl group having 5 to 10 carbon atoms, R ⁴ represents a hydrocarbon group having 1 to 8 carbon atoms, R ⁵ represents a methyl group, an ethyl group or a benzyl group, and X represents a methyl group, an ethyl group or a benzyl group. It represents a chlorine atom, a bromine atom, an iodine atom, a methyl sulfate group or an ethyl sulfate group, and a represents a number of 1 to 3).

(In the formula, R ⁶ represents a pentyl group, a hexyl group, a heptyl group, an octyl group or a nonyl group , R ⁷ represents a hydrocarbon group having 1 to 8 carbon atoms, and R ⁸ represents a methyl group, an ethyl group or a benzyl group. , Z represents a chlorine atom, a bromine atom, a iodine atom, a methyl sulfate group or an ethyl sulfate group, and b represents a number of 1 to 3).

(In the formula, R ⁹ represents an alkyl group having 5 to 10 carbon atoms, R ¹⁰ represents a hydrogen atom, a methyl group or an ethyl group, and R ¹¹ represents a hydrogen atom or a group represented by the following general formula (6). ^{R 12} represents a methyl group, an ethyl group or a benzyl group, Q represents a chlorine atom, a bromine atom, a iodine atom, a methyl sulfate group, an ethyl sulfate group or an ethyl sulfate group, and c is a number 1 to 3. Represents.)

(In the formula, R ¹³ represents an alkyl group having 5 to 10 carbon atoms.) The antibacterial composition according to claim 1, wherein the ratio of the component (B) to 100 parts by mass of the component (A) is 0.01 to 20 parts by mass. The antibacterial composition according to claim 1 or 2, further containing the component (C) which is a chelating agent. The antibacterial composition according to any one of claims 1 to 3, further comprising the component (D) which is a low molecular weight polyol. Further, claim 1 containing the component (E) which is one or more compounds selected from the group consisting of a nitrogen-containing nonionic surfactant, a nitrogen-containing amphoteric surfactant, a plant-derived extract, and a zinc compound. The antibacterial composition according to any one of 4 to 4. The antibacterial composition according to any one of claims 1 to 5, wherein the antibacterial composition is a hypoallergenic antibacterial composition. A cosmetic composition containing the antibacterial composition according to any one of claims 1 to 6. A sheet-like product for skin containing the antibacterial composition according to any one of claims 1 to 6 in a sheet-like fiber. A method for imparting antibacterial properties to a cosmetic, which comprises adding the antibacterial composition according to any one of claims 1 to 6 to the cosmetic.