WO2014115726A1 - Antibacterial composition - Google Patents

Abstract

Provided is an antibacterial composition having high antibacterial action against bacteria, molds, yeasts, and other microbial species, exhibiting outstanding antiseptic activity while being highly safe. This antibacterial composition contains the following component (A) and component (B). Component (A): a compound represented by formula (1) below (wherein R is a C5-21 linear or branched alkyl or alkenyl group), and component (B) is at least one antibacterial compound selected from p-oxybenzoic acid esters and salts thereof, phenoxyethanol, benzoic acid and salts thereof, salicylic acid and salts thereof, sorbic acid and salts thereof, dehydroacetic acid and salts thereof, polylysines, C3-5 1,3-alkane diols, and C5-12 1,2-alkane diols.

Description

Antibacterial composition

The present invention relates to an antibacterial composition suitably used as a skin external preparation. This application claims the priority of Japanese Patent Application No. 2013-012045 for which it applied to Japan on January 25, 2013, and uses the content here.

Conventionally, as a preservative used in a skin external preparation, paraoxybenzoic acid ester or a salt thereof (hereinafter sometimes referred to as “paraben”), phenoxyethanol, benzoic acid or a salt thereof, sorbic acid or a salt thereof, or gluconic acid Antibacterial compounds such as chlorhexidine have been used. However, some of the antibacterial compounds are known to have safety problems that may cause irritation to the skin and cause allergic reactions. Some have been suspected of being an environmental hormone that has become a problem in recent years. Furthermore, the antibacterial compounds have a limited number of objects that exhibit antibacterial effects. For example, paraben has a high antibacterial action against bacteria but has a low antibacterial action against mold and yeast. ing. Therefore, in the case of suppressing the growth of bacteria with only the antibacterial compound, it is necessary to make the external preparation for skin contain a high concentration, which is a problem in terms of safety. Furthermore, in an aqueous skin preparation for external use, the antibacterial compound reacts with, adsorbs, or associates with the base to be inactivated, or the partition coefficient to the aqueous phase is small and the antiseptic effect cannot be sufficiently obtained. There are many cases. Therefore, various attempts have been made to improve the antibacterial action of the antibacterial compound and reduce the amount used.

Patent Documents 1, 2, and 3 use parabens and the like together with 1,2-alkanediol, catechins, or α-methyl-1,3-benzenedioxol-5-propanal, which is a fragrance component. A method for increasing the antibacterial action of parabens and reducing the amount used is described. However, the method described above is insufficient in the effect of enhancing the antibacterial action of the antibacterial compound against mold and yeast, and the reduction in the amount of use is not satisfactory. That is, there is a demand for a compound that can be used in combination with an antibacterial compound such as paraben to improve the antibacterial action of the antibacterial compound against mold and yeast, and to reduce the amount of use of the compound further.

Japanese Patent Laid-Open No. 11-310506 JP 2005-306819 A JP 2009-78984 A

Therefore, the object of the present invention is to provide an antibacterial composition having a high antibacterial action against bacterial species such as bacteria, mold, yeast, etc., exhibiting an excellent antiseptic effect, and excellent in safety. There is to do.

As a result of intensive studies to solve the above problems, the present inventors have found that N- (2,3-dihydroxypropyl) fatty acid amide compounds have low irritation, excellent safety, and excellent antibacterial action. When an antibacterial compound that has been conventionally used is used in combination with an N- (2,3-dihydroxypropyl) fatty acid amide compound, bacteria, fungi, yeast, etc., compared to the case where the antibacterial compound is used alone. It has been found that the antibacterial effect on the bacterial species of the above is dramatically increased, the amount of the antibacterial compound used can be reduced to an extremely low level, and thereby an antibacterial composition excellent in antibacterial action and safety can be obtained. The present invention has been completed based on these findings.

That is, this invention provides the antibacterial composition containing the following component (A) and component (B).
Component (A): Compound represented by the following formula (1)

(Wherein R represents a linear or branched alkyl or alkenyl group having 5 to 21 carbon atoms)
Ingredient (B): Antibacterial compound

In addition, the component (B) is paraoxybenzoic acid ester and salts thereof, phenoxyethanol, benzoic acid and salts thereof, salicylic acid and salts thereof, sorbic acid and salts thereof, dehydroacetic acid and salts thereof, polylysine, 1 having 3 to 5 carbon atoms. The antibacterial composition described above contains at least one antibacterial compound selected from 1,2-alkanediol and 1,2-alkanediol having 5 to 12 carbon atoms.

Also provided is the above antibacterial composition containing 0.001 to 10% by weight of component (A) and 0.01 to 20% by weight of component (B) in the total amount (100% by weight) of the antibacterial composition. .

Also provided is the antibacterial composition used as an external preparation for skin.

That is, the present application relates to the following.
(1) An antibacterial composition containing the following component (A) and component (B).
Component (A): Formula (1) (wherein R represents a linear or branched alkyl group or alkenyl group having 5 to 21 carbon atoms)
Compound (B): Antibacterial compound (2) Component (B) is paraoxybenzoic acid ester and salts thereof, phenoxyethanol, benzoic acid and salts thereof, salicylic acid and salts thereof, sorbic acid and salts thereof, dehydroacetic acid And (1) containing at least one antibacterial compound selected from salts thereof, polylysines, 1,3-alkanediols having 3 to 5 carbon atoms, and 1,2-alkanediols having 5 to 12 carbon atoms The antibacterial composition as described.
(3) (1) or (2) containing 0.001 to 10% by weight of component (A) and 0.01 to 20% by weight of component (B) in the total amount (100% by weight) of the antibacterial composition The antibacterial composition as described.
(4) Antibacterial compound selected from paraoxybenzoic acid ester and salts thereof, phenoxyethanol, benzoic acid and salts thereof, salicylic acid and salts thereof, sorbic acid and salts thereof, and dehydroacetic acid and salts thereof as component (B) The antibacterial composition according to any one of (1) to (3), containing 0.01 to 20.0% by weight of the total amount (100% by weight) of the antibacterial composition.
(5) An antibacterial compound selected from 1,3-alkanediol having 3 to 5 carbon atoms and 1,2-alkanediol having 5 to 12 carbon atoms as the component (B) 100% by weight) 0.1 to 30.0% by weight of the antibacterial composition according to any one of (1) to (3).
(6) The antibacterial composition according to any one of (1) to (5), which is used as a skin external preparation.

Since the antibacterial composition of the present invention has the above-described configuration, it has a high antibacterial action against bacterial species such as bacteria, molds and yeast that cause contamination of the external preparation for skin, and exhibits a sufficient antiseptic effect. it can. Furthermore, in the antibacterial composition of the present invention, the amount of the antibacterial compound such as paraben used can be reduced as compared with the conventional one, which is excellent in terms of safety.

3 is a ¹ H-NMR spectrum analysis result of the compound 1a obtained in Synthesis Example 2. 3 is a result of ¹³ C-NMR spectrum analysis of Compound 1a obtained in Synthesis Example 2. FIG. It is IR spectrum analysis result of the compound 1a obtained by the synthesis example 2.

[Component (A)]
The antibacterial composition of the present invention is characterized by containing, as component (A), a compound represented by the following formula (1) alone or in combination of two or more.

In the formula, R represents a linear or branched alkyl group or alkenyl group having 5 to 21 carbon atoms. Examples of the RCO group in which R is a linear or branched alkyl group having 5 to 21 carbon atoms include n-pentanoyl, isopentanoyl, n-hexanoyl, n-octanoyl, isooctanoyl, 2-ethylhexanoyl. And 3-ethylhexanoyl, n-nonanoyl, isononyl, n-decanoyl, isodecanoyl, n-undecanoyl, n-dodecanoyl, n-tetradecanoyl, n-hexadecanoyl and n-eicosanoyl groups. Examples of the RCO group in which R is a linear or branched alkenyl group having 5 to 21 carbon atoms include n-pentenoyl, isopentenoyl, n-hexenoyl, n-octenoyl, isooctenoyl, 2-ethylhexenoyl, Specific examples include 3-ethylhexenoyl, n-nonenoyl, isononenoyl, n-decenoyl, isodecenoyl, n-undecenoyl, n-dodecenoyl, n-tetradecenoyl, n-hexadecenoyl, n-eicosenoyl and the like.

In the present invention, among them, since it can exhibit an excellent antibacterial action and has water solubility, the number of carbon atoms can be sufficiently exhibited in an aqueous skin external preparation composition. A linear alkyl group or alkenyl group having 5 to 15 carbon atoms (most preferably a linear alkyl group having 5 to 15 carbon atoms) is preferable. When the carbon number of R exceeds the above range, the water solubility is lowered, the partition coefficient to the aqueous phase is small, and the antiseptic effect cannot be sufficiently obtained in the aqueous skin external preparation composition, turbidity occurs, or crystals are formed at low temperatures. May occur.

The compound represented by the formula (1) is produced, for example, by reacting a compound represented by the following formula (2) with a fatty acid halide represented by the following formula (3) in the presence of a basic compound. (Schotten-Baumann method). X in the following formula (3) represents a halogen atom. R is the same as R in formula (1).

As the basic compound, a basic compound generally used in the Schotten-Baumann method can be used. For example, sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium carbonate, potassium carbonate, sodium hydrogen carbonate, etc. Inorganic bases; organic bases such as pyridine and triethylamine can be used. These can be used alone or in combination of two or more. In the present invention, among them, an inorganic base is preferable, and sodium hydroxide and potassium hydroxide are particularly preferable from the viewpoints of solubility in water and reactivity.

The amount of the basic compound used is, for example, about 1.0 to 1.2 mol with respect to 1 mol of the compound represented by the formula (3). When the amount of the basic compound used is less than the above range, it tends to be difficult to complete the reaction sufficiently. On the other hand, when the usage-amount of a basic compound exceeds the said range, there exists a tendency for workability to fall for a catalyst removal operation in a post-processing process, and to fall. In addition, there is a concern that the antibacterial composition containing the compound represented by the formula (1) obtained thereby may adversely affect the quality, for example, the pH may be shifted to the alkali side.

The above reaction is performed in the presence or absence of a solvent. The solvent can be appropriately selected according to the type of the substrate and the target compound. Examples of the solvent include aromatic hydrocarbons such as benzene, toluene, xylene, and ethylbenzene; aliphatic hydrocarbons such as hexane, heptane, and octane; alicyclic hydrocarbons such as cyclopentane and cyclohexane; carbon tetrachloride, chloroform Halogenated hydrocarbons such as dichloromethane, 1,2-dichloroethane; carboxylic acids such as acetic acid, propionic acid, butyric acid; ketones such as acetone, methyl ethyl ketone, cyclopentanone, cyclohexanone; methyl acetate, ethyl acetate, isopropyl acetate, butyl acetate Esters such as: N, N-dimethylformamide, amides such as N, N-dimethylacetamide; Nitriles such as acetonitrile, propionitrile, benzonitrile; Diethyl ether, dibutyl ether, dimethoxyethane, dioxane, tetrahydride Furan, chain or cyclic ethers such as ethylene glycol monobutyl ether; methanol, ethanol, isopropanol, may be mentioned alcohols such as 2-ethylhexyl alcohol. These can be used alone or in combination of two or more. Moreover, since the reaction rate of a fatty acid halide and an amine compound is usually sufficiently faster than the solvolysis rate of an acid halide, the above solvent can be mixed with water for use.

The reaction temperature of the above reaction is, for example, about −70 ° C. to 60 ° C., preferably 0 ° C. to 20 ° C.

The reaction time for the above reaction is not particularly limited as long as the temperature in the reaction system can be controlled within the above range by the heat removal capability of the reaction apparatus, but it is, for example, about 0.5 to 10 hours, preferably 1 to 5 hours. If an attempt is made to complete the reaction in a very short time, reaction heat exceeding the range of the heat removal capability of the reactor is generated, the reaction solution temperature rises, the raw material is decomposed, and the selectivity of the reaction decreases. Since a by-product increases, it is not preferable. Further, it is not preferable to spend too much time because productivity is lowered.

In addition to the Schotten-Baumann method, the compound represented by the formula (1) includes a compound represented by the following formula (2) and a fatty acid alkyl ester represented by the following formula (4) in the presence of a transesterification catalyst. It can also be produced by reacting (transesterification reaction). In the formula (4), R ′ represents a linear or branched alkyl group having about 1 to 10 carbon atoms. R is the same as R in formula (1).

As the transesterification catalyst, a known transesterification catalyst can be used. A transesterification catalyst can be used individually by 1 type or in mixture of 2 or more types. In the present invention, a basic catalyst is particularly preferable. The basic catalyst includes a nitrogen-containing basic compound, an alkali metal compound, an alkaline earth metal compound, and the like.

The nitrogen-containing basic compound includes an electron-donating nitrogen-containing heterocyclic compound or a salt thereof, a chain amine or a salt thereof, ammonium hydroxide, and the like. Examples of the electron-donating nitrogen-containing heterocyclic compound include 2-aminopyridine, 4-aminopyridine, 2-hydroxypyridine, 4-hydroxypyridine, 2-methoxypyridine, 4-methoxypyridine, 4-dimethylaminopyridine, 4 Pyridines such as diethylaminopyridine, 4-pyrrolidinopyridine, 4- (4-methylpyrrolidinyl) pyridine, 4- (4-methyl-1-piperidinyl) pyridine; quinolines such as aminoquinoline; imidazole, 2- Imidazoles such as dimethylaminoimidazole, 2-methoxyimidazole, 2-methylimidazole, 4-methylimidazole, 2-mercaptoimidazole; benzimidazoles such as benzimidazole; diazabicyclooctane (DABCO), 1,8-diazabicyclo [ 5.4 0] -7-undecene (DBU), and the like.

Examples of the chain amines include tertiary amines such as trimethylamine, triethylamine and N, N-dimethylaniline; secondary amines such as dimethylamine, diethylamine and N-methylaniline; methylamine, ethylamine and benzylamine. And primary amines such as aniline.

Electron-donating nitrogen-containing heterocyclic compounds and chain amines include organic acid salts such as formate, acetate and oxalate; carbonates, nitrates, nitrites, sulfates, phosphates, fluorides Examples thereof include inorganic acid salts such as borates and borohydrides. Examples of the ammonium hydroxides include tetramethylammonium hydroxide and tetraethylammonium hydroxide.

Examples of the alkali metal compound include hydroxides such as sodium hydroxide and potassium hydroxide; carbonates such as sodium carbonate and potassium carbonate; hydrogen carbonates such as sodium hydrogen carbonate and potassium hydrogen carbonate; sodium borate and boron Borates such as potassium acid; borohydrides such as sodium borohydride and potassium borohydride; hydrogen diphosphates such as disodium hydrogen phosphate and dipotassium hydrogen phosphate; sodium acetate, potassium acetate and stearin Organic acid salts such as sodium acid, potassium stearate, sodium benzoate and potassium benzoate; alkoxides such as sodium methoxide, sodium ethoxide, potassium methoxide, potassium ethoxide and cesium methoxide; disodium salt of bisphenol A; Dipotassium salt of bisphenol A Sodium salt of phenol, salts of phenols such as potassium salt of phenol and the like.

Examples of the alkaline earth metal compound include hydroxides such as magnesium hydroxide and calcium hydroxide; carbonates such as magnesium carbonate and calcium carbonate; borate salts such as magnesium borate and calcium borate; magnesium acetate; Examples thereof include organic acid salts such as calcium acetate, magnesium stearate and calcium stearate.

The amount of the transesterification catalyst used is, for example, about 0.001 to 0.1 mol with respect to 1 mol of the compound represented by the formula (4). When the amount of the transesterification catalyst used is below the above range, it tends to be difficult to complete the reaction sufficiently. On the other hand, if the amount of the transesterification catalyst used exceeds the above range, the catalyst removal operation in the post-treatment process is troublesome and the workability tends to decrease.

The transesterification reaction is performed in the presence or absence of a solvent. The solvent can be appropriately selected according to the type of the substrate and the target compound. The solvent does not react with the raw material, has a higher boiling point than the by-produced alcohol, is easily removed in a later process, and even if it remains in the product for the intended use, It is preferable to use a solvent that does not have any restrictions such as repelling due to harmfulness. For example, aromatic hydrocarbons such as benzene, toluene, xylene, and ethylbenzene; aliphatic hydrocarbons such as hexane and octane; alicyclic rings such as cyclohexane Halogenated hydrocarbons such as 1,2-dichloroethane; Ketones such as acetone, methyl ethyl ketone, cyclopentanone and cyclohexanone; Amides such as N, N-dimethylformamide and N, N-dimethylacetamide; Acetonitrile, Propio Nitriles such as nitrile and benzonitrile; dibutyl ether, dimethoxyethane, geo Linear or cyclic ethers such as sun, tetrahydrofuran, ethylene glycol monobutyl ether, cyclopentyl methyl ether; isopropanol, 2-ethylhexyl alcohol, ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol Examples thereof include alcohols such as alkyl sulfoxide compounds such as dimethyl sulfoxide. These can be used alone or in combination of two or more.

The reaction temperature for the transesterification is, for example, about 30 to 150 ° C., preferably 50 to 120 ° C. If the reaction temperature is too high, the selectivity of the reaction tends to decrease and by-products tend to increase.

The reaction time for the transesterification is, for example, about 3 to 60 hours, preferably 4 to 50 hours. If the reaction time is too long, productivity tends to decrease. In that case, it is preferable to adjust the reaction time within an appropriate range, for example, by changing the type and amount of the catalyst.

The atmosphere of the Schotten-Baumann method reaction and the transesterification reaction is not particularly limited as long as the reaction is not inhibited. For example, the reaction is preferably performed in an inert gas atmosphere such as a nitrogen atmosphere or an argon atmosphere. Further, the reaction can be carried out by any method such as batch, semi-batch and continuous methods.

After completion of the reaction, the obtained compound is separated and purified by separation and purification means such as filtration, centrifugation, concentration, distillation, extraction, crystallization, recrystallization, adsorption, column chromatography, etc., or a combination of these. Can do.

The content of the component (A) is preferably about 0.001 to 10.0% by weight, for example, in the total amount (100% by weight) of the antibacterial composition. When the content of the component (A) is below the above range, it tends to be difficult to obtain a sufficient antiseptic effect. On the other hand, when the content of the component (A) exceeds the above range, the skin irritation tends to increase.

[Component (B)]
The antibacterial composition of this invention contains the antibacterial compound normally used for a skin external preparation as a component (B).

Examples of the antibacterial compounds include paraoxybenzoic acid esters and salts thereof, phenoxyethanol, benzoic acid and salts thereof, salicylic acid and salts thereof, sorbic acid and salts thereof, dehydroacetic acid and salts thereof, polylysines, and carbon number 3-5. 1,3-alkanediol, 1,2-alkanediol having 5 to 12 carbon atoms, isothiazolinone derivatives such as methylchloroisothiazolinone, methylisothiazolinone, imidazolinium urea, halogenated bisphenols (triclosan, etc.) , Acid amides, quaternary ammonium salts, trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol Phenols (phenol, isopropyl phenol, cresol, thymol, p-chlorophenol, phenylphenol, phenylphenol sodium and the like), phenyl ethyl alcohol, photosensitive Motorui, antibacterial zeolite, mention may be made of silver ions. These can be used alone or in combination of two or more.

Examples of the paraoxybenzoic acid ester and salts thereof include, for example, methyl paraoxybenzoate (hereinafter sometimes referred to as “methylparaben”), ethyl paraoxybenzoate, propyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, Specific examples include isobutyl paraoxybenzoate and benzyl paraoxybenzoate. Examples of the salt of the paraoxybenzoic acid ester include methyl sodium paraoxybenzoate, ethyl sodium paraoxybenzoate, and sodium propyl sodium paraoxybenzoate.

Examples of the benzoic acid salts include sodium benzoate, potassium benzoate, benzyl benzoate, aluminum benzoate, ammonium benzoate, pantothenylethyl benzoate, and the like.

Examples of the salts of salicylic acid include magnesium salicylate, sodium salicylate, triethanolamine salicylate, ethylhexyl salicylate, titanium salicylate, and the like.

Examples of the sorbic acid salts include calcium sorbate, potassium sorbate, and sodium sorbate.

Examples of dehydroacetic acid salts include sodium dehydroacetate.

Examples of the 1,3-alkanediol having 3 to 5 carbon atoms include 1,3-propanediol and 1,3-butylene glycol.

Examples of the 1,2-alkanediol having 5 to 12 carbon atoms include 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 3- (2 And -ethylhexyloxy) propane-1,2-diol.

As component (B), an antibacterial compound selected from paraoxybenzoic acid esters and salts thereof, phenoxyethanol, benzoic acid and salts thereof, salicylic acid and salts thereof, sorbic acid and salts thereof, and dehydroacetic acid and salts thereof is used. In this case, the amount used (the total amount when two or more types are used) can be appropriately adjusted according to the type and purpose of the antibacterial compound, and is, for example, 0 in the total amount (100% by weight) of the antibacterial composition. The amount is about 0.01 to 20.0% by weight, and 0.01 to 1.0% by weight is particularly preferable because the skin irritation can be suppressed to a very low level. When the content of the antibacterial compound is below the above range, it tends to be difficult to obtain a sufficient antibacterial action. On the other hand, when the content of the antibacterial compound exceeds the above range, skin irritation tends to increase.

When an antibacterial compound selected from 1,3-alkanediol having 3 to 5 carbon atoms and 1,2-alkanediol having 5 to 12 carbon atoms is used as component (B), the amount used (two kinds) When using the above, the total amount thereof) can be appropriately adjusted according to the type and purpose of the antibacterial compound, and is 0.1 to 30.0% by weight in the total amount of the antibacterial composition (100% by weight), for example. The degree is preferable, and 0.1 to 15.0% by weight is particularly preferable in terms of imparting smoothness and moist feeling to the skin. When the content of the antibacterial compound is below the above range, it tends to be difficult to obtain a sufficient antibacterial action. On the other hand, when the content of the antibacterial compound exceeds the above range, stickiness is generated and the usability tends to decrease.

In the present invention, among others, paraoxybenzoic acid esters and salts thereof, phenoxyethanol, benzoic acid and salts thereof, 1,3-alkanediol having 3 to 5 carbon atoms, and 1,2-alkanediol having 5 to 12 carbon atoms It is preferable that it contains at least one selected from the above because it is suitable for use as a skin external preparation.

[Antimicrobial composition]
The antibacterial composition of the present invention contains the component (A) and the component (B).

The antibacterial composition of the present invention can be suitably used as a skin external preparation. The topical skin preparation in the present invention is a concept encompassing all compositions applied to the outer skin (skin, hair, etc.), and includes compositions used in all methods other than internal use, such as various uses ( Skin care use, makeup use, toiletry use, hair care use, treatment use, etc.), cosmetics, pharmaceuticals, quasi-drugs, miscellaneous goods, etc. More specifically, the external preparation for skin is a cleansing cosmetic, a hair cosmetic, a basic cosmetic, a makeup cosmetic, an aromatic cosmetic, a sunscreen / sunscreen cosmetic, a nail cosmetic, and an eyeliner cosmetic. Cosmetics such as lip cosmetics, oral cosmetics and bath cosmetics; quasi-drugs for hair growth, hair restoration and anti-dandruff (for hair); for the treatment of spots, freckles, acne, inflammation, etc. Quasi-drugs (external use for skin); permanent wave agents, hair dyes; acne drugs, wound healing drugs, gargles, and other drugs.

In addition to the above components (A) and (B), the antibacterial composition of the present invention is a component that is usually used for an external preparation for skin (for example, an oily base, a moisturizing agent) within the range not impairing the effects of the present invention Agents / feel improvers, surfactants, thickeners / gelling agents, solvents / propellants, antioxidants, reducing agents, oxidizing agents, chelating agents, pH adjusters, powders, inorganic salts, UV absorption Agents, whitening agents, vitamins and derivatives thereof, anti-inflammatory agents / anti-inflammatory agents, hair-restoring agents / blood circulation promoters / stimulants, hormones, anti-wrinkle agents, anti-aging agents, squeeze agents, cooling agents, warming agents , Wound healing promoters, stimulant / palliatives, analgesics, cell activators, plant / animal / microbe extracts, antipruritics, exfoliating / dissolving agents, antiperspirants, refreshing agents, astringents, nucleic acids, fragrances, pigments -Colorants, dyes, pigments, water, etc.) can be appropriately blended.

Examples of the oily base include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyl decanol, Stearyl alcohol, 2-octyldodecanol, higher alcohols such as dimer diol, aralkyl alcohol (benzyl alcohol, etc.) and derivatives; long chain fatty acids (lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylene) Acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, ray Higher fatty acids such as dipentaic acid, isohexadecanoic acid, antiisohenicosanoic acid), dimer acid, hydrogenated dimer acid; aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, sodium of the higher fatty acids Metal soaps such as salts; nitrogen-containing derivatives such as amide derivatives of the above higher fatty acids; paraffin, liquid paraffin, liquid isoparaffin, light isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane , Hydrocarbons such as squalene, petrolatum, solid paraffin, pristane; candelilla wax, carnauba wax, rice wax, wax, beeswax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, micro Waxes such as crystallin wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil , Macadamia nut oil, hazelnut oil, cucumber nut oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil Vegetable oils such as rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil, etc. Animal fats and oils; animal waxes such as whale wax and orange luffy oil; Norrin, liquid lanolin, reduced lanolin, adsorption purified lanolin, lanolin acetate, acetic acid liquid lanolin, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester, etc. Lanolins: Phospholipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipid (such as sphingomyelin), phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid Phospholipid derivatives such as lipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid; sapogenins; saponins; phospholipid / cholesterol complex , Lipid complexes such as phospholipid / phytosterol complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl pariminate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, Isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl Hexyldecyl octoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, oleic acid Ethyl, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, adipic acid Diisobutyl, dioctyl succinate, cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, triethyl citrate, glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (caprylic acid / Capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin trigly Lido, rosin triglyceride, (behenic acid / eicosandioic acid) glyceryl, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl dioctanoate 1,3-propanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, (isostearic acid / sebacic acid) ditrimethylolpropane, pentaerythrityl triethylhexanoate , (Hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diglyceryl diisostearate, polyisotetrastearate Seryl, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, ethylene glycol distearate, 3-methyl-1,5 neodynoate -Esters such as pentanediol and 2,4-diethyl-1,5-pentanediol dineopentanoate; diisopropyl dimerlinoleate, diisostearyl dimerdilinoleate, dimerlinoleyl dimerinolinoleate, dimer stearic acid dimer Dimer acid or dimer diol derivative such as linoleyl, dimer linoleyl hydrogenated rosin condensate, dimer linoleic acid hydrogenated castor oil, hydroxyalkyl dimer linoleyl ether; Ceramides such as natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudoceramides, glycosphingolipids, ceramides and sugar-ceramide-containing extracts; coconut oil fatty acid monoethanolamide, coconut oil fatty acid diethanolamide , Fatty acid alkanolamides such as lauric acid monoethanolamide, lauric acid diethanolamide, lauric acid monoisopropanolamide, palmitic acid monoethanolamide, palmitic acid diethanolamide, palm oil fatty acid methylethanolamide; dimethicone, highly polymerized dimethicone, cyclo Methicone, phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol Dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone (aminopropyl dimethicone, amodimethicone, etc.), cation-modified silicone, polyether-modified silicone (dimethicone copolyol, etc.), polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid modification Silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone, peptide modified silicone, fluorine modified silicone, cationic modified and polyether modified silicone, amino modified and polyether modified Silicones such as silicone, alkyl-modified and polyether-modified silicone, polysiloxane / oxyalkylene copolymer; Fluoro decane, perfluoro octane, fluorine-based oils such as perfluoropolyether; can be exemplified ethers such as dicaprylyl ether and the like.

Examples of the humectant / feel improver include glycerin, 3-methyl-1,3-butanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, Polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, polyols such as ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol di Glycol alkyl ethers such as butyl ether; (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10, tetradecanedioic acid poly Water-soluble esters such as lysyl-10; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose , Lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin and modified cyclodextrins such as maltosylation, hydroxyalkylation, etc.), β-glucan, chitin, chitosan, Sugars such as heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer, and the like Hyaluronic acid, sodium hyaluronate; chondroitin sulfate sodium; mucoitin sulfate, caroline sulfate, kerato sulfate, dermatan sulfate, white jellyfish extract, white jellyfish polysaccharide, fucoidan, tuberose polysaccharide, natural polysaccharide, organic acid (citric acid , Tartaric acid, lactic acid, etc.) and salts thereof, urea, 2-pyrrolidone-5-carboxylic acid and salts thereof (sodium salt, etc.); betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, Phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, etc. No acids and salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, Hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide, acylated peptide and other protein peptides and derivatives thereof; Acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane Protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placental extract, aerustin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract , Comfrey extract, Silk extract, Izayoi rose extract, Achillea millefolium extract, Eucalyptus extract, Merirot extract and other animal / plant extract components, natural ceramide ( types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudo Examples include ceramides such as ceramide, glycosphingolipid, ceramide and sugar-ceramide-containing extract.

The surfactant includes an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, You may use it combining a low thing and a high thing of HLB.

Examples of the anionic surfactant include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate and ammonium lauryl sulfate; sodium laureth sulfate and trilaurate sulfate. Polyoxyethylene alkyl sulfates such as ethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanolamine, lauroyl glutamate methylalanine Acyl N-methyl amino acid salts such as sodium; sodium cocoyl glutamate, coco Acylamino acid salts such as triethanolamine luglutamate, sodium lauroylglutamate, sodium myristoyl glutamate, sodium stearoylglutamate, ditriethanolamine palmitoylaspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; lauroyl Succinic acid ester salts such as sodium monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; fatty acid glycerides such as hardened coconut oil fatty acid sodium glycerol sulfate Sulfates; alkylbenzene polyoxyethylene sulfates; sodium α-olefin sulfonates, etc. Olefin sulfonates; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; alkyl ethers such as disodium laureth sulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate Sulfosuccinate; alkyl benzene sulfonates such as sodium tetradecylbenzene sulfonate and triethanolamine tetradecyl benzene sulfonate; alkyl naphthalene sulfonate; alkane sulfonate; α-sulfo fatty acid methyl ester salt; acyl isethionate; alkyl Glycidyl ether sulfonate; alkyl sulfoacetate; sodium laureth phosphate, dilaureth Alkyl ether phosphate esters such as sodium phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate esters such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide ether phosphate Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; and silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone.

Examples of the nonionic surfactant include polyoxyethylene alkyl ethers having various polyoxyethylene addition numbers such as laureth, ceteth, steares, behenez, isosteares, octyldecesses, etc .; polyoxyethylene alkylphenyl Ether: Polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid Hydrogenated castor oil and its derivatives such as diester, polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol Polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene polyoxypropylene monobutyl ether, polyoxyethylene Polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ether such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) glycerin polyoxy such as PPG-9 diglyceryl Propylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, oleate Glycerin fatty acid partial esters such as ceryl, coconut oil fatty acid glyceryl, mono cottonseed oil fatty acid glycerin, monoerucic acid glycerin, sesquioleic acid glycerin, α, α'-oleic acid pyroglutamic acid glycerin, (stearic acid / malic acid) glyceryl; Polyglyceryl-2, 3, 4, 5, 6, 8, 10, polyglyceryl-6 distearate, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, polyglyceryl-2 isostearate 3, 4, 4, 6, 8, 10, polyglyceryl-2 diisostearate, 3, 10, polyglyceryl triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl decaisostearate 10 Polyglyceryl fatty acid esters such as polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 8, 10 oleate, polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, polyglyceryl-10 dekaoleate; mono Ethylene glycol monofatty acid ester such as ethylene glycol stearate; propylene glycol monofatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid ester; maltitol partial fatty acid ester; maltitol ether; sorbitan monooleate; Sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan triole Sorbitan fatty acid esters such as diphosphate sorbitan, tetra-2-ethylhexyl acid diglycerol sorbitan; sugar partial ester such as sucrose fatty acid ester, methyl glucoside fatty acid ester, undecylenic acid trehalose; caprylyl Alkyl glucosides such as glucosides; alkyl polyglycosides; lanolin alcohols; reduced lanolins; polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene diolate Polyoxyethylene propylene glycol fatty acid ester; polyoxyethylene glycerol monostearate, polyoxyethylene glycerol monoester Polyoxyethylene glycerin fatty acid esters such as isostearate, polyoxyethylene glycerin triisostearate, polyoxyethylene glycerin monooleate; polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate, etc. Polyoxyethylene sorbitol fatty acid ester of polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol fatty acid ester such as polyoxyethylene sorbitol monostearate; polyoxyethylene methyl Glucoside fatty acid ester; polyoxyethylene alkyl ether fatty acid ester Polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; Alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ether; polyoxyethylene alkylamine; tetrapoly Oxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil fatty acid monoethanolamide, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, lauric acid Acid diethanolamide, lauric acid monoisopropanolamide, palmitic acid monoethanolamide, palmitic acid diethanolamide, coconut oil fatty acid Fatty acid alkanolamides such as tilethanolamide; alkyl dimethyl amine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkyl ethoxy dimethyl amine oxide; polyoxyethylene alkyl mercaptan; dimethicone copolyol, etc. Examples thereof include silicone-based nonionic surfactants such as polyether-modified silicone, polysiloxane / oxyalkylene copolymer, polyglycerin-modified silicone, and sugar-modified silicone.

Examples of the cationic surfactant include fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ether amines such as stearoxypropyldimethylamine and salts or quaternary salts thereof; polyoxy Alkylamine salts; fatty acid amidoguanidinium salts; alkyl ether ammonium salts; alkyltrialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; Imidazolinium salts; alkylisoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyl dimethicone and amodimethicone; cations Sex silicones, cationic-modified and polyether-modified silicone, and silicone-based cationic surfactants such as amino-modified, and polyether-modified silicone.

Examples of the amphoteric surfactant include N-alkyl-N, N-dimethylamino acid betaines such as lauryldimethylaminoacetic acid betaine; fatty acid amide alkyl-N, N-dimethylamino acids such as cocamidopropyl betaine and lauramidopropyl betaine Betaines; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; Sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated Bean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipids, phospholipids such as hydroxylated lecithin; and silicone-based amphoteric surface active agent.

Examples of the polymer surfactant include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / (meth) acrylate alkyl copolymer; various silicone surfactants, and the like.

Examples of the thickener / gelling agent include guar gum, cassia gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, far celeran, karaya gum, trooaoi, cara gum, tragacanth gum, pectin, pectinic acid And salts thereof (sodium salt, etc.), alginic acid and salts thereof (sodium salt, etc.), mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, pullulan , Gellan gum, chitin, chitosan, agar, cassava extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose Hydroxypropylcellulose, carboxymethylcellulose and salts thereof (sodium salt, etc.), methylhydroxypropylcellulose, cellulose sodium sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder and the like; soluble starch, carboxymethyl starch, methyl Starch-based polymers such as hydroxypropyl starch and methyl starch; starch derivatives such as hydroxypropyltrimonium chloride, corn starch aluminum octenyl succinate; alginic acid derivatives such as sodium alginate, propylene glycol ester alginate; polyvinyl pydridone, polyvinyl alcohol, vinyl pidridone Vinyl alcohol copolymer, polyvinyl methyl ester Ter; polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymers; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; poly Acrylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate; Carboxyvinyl polymer; Polyacrylic acid and its salts (sodium salt, etc.); Acrylic acid / (meth) acrylic acid ester copolymer; Acrylic acid / (Metal ) Alkyl acrylate copolymer; cationic cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, polyquaternium- Acrylic acid / diallyldimethylammonium chloride / acrylamide copolymer such as 39, acrylic acid / cationized (meth) acrylic acid ester copolymer, acrylic acid / cationized (meth) acid amide copolymer, poly Acrylic acid, methyl acrylate, methacrylamidopropyltrimethylammonium chloride copolymer, methacrylic acid choline ester polymer such as onium-47; cationized oligosaccharide, cationized cassia, cationized dextran, guar hydroxypropyltrimonium chloride, etc. Polyethyleneimine; Cationic polymer; Copolymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer of butyl methacrylate; acrylic resin emulsion, polyethyl acrylate emulsion, Polymer emulsion such as polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethane And copolymers thereof; silicones; silicone copolymers such as acrylic-silicone graft copolymers; fluoropolymers; 12-hydroxystearic acid and salts thereof; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate Silicic anhydride, fumed silica (ultrafine silicic acid anhydride), magnesium magnesium silicate, magnesium magnesium silicate, metal soap, metal dialkyl phosphate, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, Examples thereof include fructooligosaccharide fatty acid esters.

Examples of the solvent / propellant include lower alcohols such as ethanol, isopropyl alcohol, butanol and isobutyl alcohol; propylene glycol, 1,3-butylene glycol, 1,3-propanediol, diethylene glycol, dipropylene glycol, isopropanol Glycols such as pentyldiol; diethylene glycol monoethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as tate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; LPG, dimethyl ether, carbon dioxide, and the like.

Examples of the antioxidant include tocopherol (= vitamin E) and its derivatives (such as tocopherol acetate), BHT, BHA, gallic acid derivatives (such as propyl gallate), vitamin C (= ascorbic acid) and its derivatives, erythorbine Acids and their derivatives, sulfites (such as sodium sulfite), bisulfites (such as sodium bisulfite), thiosulfates (such as sodium thiosulfate), metabisulfites, thiotaurine, hypotaurine, thioglycerol, thiourea, thioglycol Examples thereof include acids and cysteine hydrochloride.

Examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like.

Examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, percarbonate, and the like.

Examples of the chelating agent include ethylenediaminetetraacetate such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na, hydroxyethylethylenediamine triacetate such as HEDTA3Na, phosphonic acid such as diethylenetriaminepentaacetate, phytic acid, and etidronic acid and salts thereof Sodium salt), sodium oxalate, polyamino acids (polyaspartic acid, polyglutamic acid, etc.), sodium polyphosphate, sodium metaphosphate, phosphoric acid, sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbine An acid, a succinic acid, tartaric acid etc. can be mentioned.

Examples of the pH adjuster include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine. , Diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide , Potassium hydroxide, aqueous ammonia, guanidine carbonate, ammonium carbonate and the like.

Examples of the powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, silicic acid. Aluminum, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay , Mud, metal soap (zinc myristate, calcium palmitate, aluminum stearate, etc.), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, suboxide , Alumina, silica, fumed silica (= ultrafine silicic anhydride), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine phlogopite, fine particle composite powder, gold, aluminum and other inorganic powders; starch, Cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, benzoguanamine resin powder, polyethylene terephthalate / polymethyl methacrylate laminate powder, polyethylene terephthalate / aluminum / epoxy Organic powders such as laminated powder, urethane powder, silicone powder, Teflon (registered trademark) powder; organic-inorganic composite powders; and the inorganic and / or organic powders as silicones such as hydrogen silicone and cyclic hydrogen silicone May include a powder or the like that has been hydrophobized or hydrophilized by treatment with another surface treatment agent such as a silane or titanium coupling agent.

Examples of the inorganic salts include sodium chloride-containing salts (salt, average salt, rock salt, sea salt, natural salt, etc.), potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride, sodium sulfate. , Aluminum sulfate, Aluminum sulfate / potassium (= Alum), Aluminum sulfate / Ammonium, Barium sulfate, Calcium sulfate, Potassium sulfate, Magnesium sulfate, Zinc sulfate, Iron sulfate, Copper sulfate, Sodium phosphates (1Na phosphate, Phosphoric acid 2Na, phosphoric acid 3Na, etc.), potassium phosphates, calcium phosphates, magnesium phosphates and the like.

Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaamino. Benzoic acid ultraviolet absorbers such as benzoic acid ethyl ester, N, N-dimethylparaaminobenzoic acid butyl ester and N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate Agents; salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, etc. Lithic acid UV absorber; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl -P-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate, 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate Cinnamic acid such as ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and its derivatives system UV absorber; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxy Benzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4 Benzophenone ultraviolet absorbers such as' -phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3- (4'-methylbenzylidene) -d , L-camphor, 3- Benzylidene-d, l-camphor, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzo Triazole, 2- (2′-hydroxy-5′-methylphenylbenzotriazole, dibenzalazine, dianisoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, 4-t- Dibenzoylmethane derivatives such as butylmethoxydibenzoylmethane, urocanic acid derivatives such as octyl triazone, urocanic acid and ethyl urocanate, 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- (3 4-Dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedi , Dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazole sulfonic acid, terephthalylidene dicamphulsulfonic acid, drometrizol trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol And derivatives thereof, methylenebisbenzotriazolyltetramethylbutylphenol, bisethylhexyloxyphenol methoxyphenyltriazine, and the like.

Examples of the whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid phosphates such as ascorbic acid, ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt Ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate, phosphoric acid Ascorbic acid derivatives such as tocopheryl ascorbyl; plant extracts such as oil-soluble chamomile extract, oil-soluble licorice extract, Nishikawayanagi extract, and yukinoshita extract; kojic acid, ellagic acid, tranexam And its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, phenylethyl resorcinol, butyl resorcinol, 2-ethyl-hexanoic acid 2- (2-ethyl-hexanoyloxy) -cyclohexyl ester, etc. .

Examples of the vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmi Tate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B such as choline; ascorbic acid and its salts (sodium salt, etc.), ascorbic acid phosphate sodium salt And ascorbic acid phosphates such as magnesium ascorbate, ascorbyl tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, dipalmi Ascorbic acid fatty acid esters such as ascorbyl acid, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, vitamin C such as tocopheryl phosphate ascorbyl; vitamin D Vitamin E such as α, β, γ, δ-tocopherol, tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, tocopherol phosphate ester, tocotrienol; other vitamins such as pantothenic acid, biotin, etc. Can be mentioned.

Examples of the anti-inflammatory / anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphenhydramine hydrochloride, chlorpheniramine maleate And plant extracts such as peach leaf extract and persimmon leaf extract.

Examples of hair growth agents / blood circulation promoters / stimulants include plant extracts and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid wallenylamide, gingeron, ictamol, Tannic acid, borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, γ-oryzanol, cephalanthin, vitamin E, vitamin E derivatives (nicotinic acid tocopherol, acetic acid tocopherol, etc.), nicotinic acid, nicotinic acid derivatives (nicotinic acid amide, Nicotinic acid benzyl ester, inositol hexanicotinate, nicotine alcohol, etc.), allantoin, photosensitive element 301, photosensitive element 401, capronium chloride, pentadecanoic acid monoglyceride, Banonoru derivatives, stigmasterol or stigmastanol and glycosides thereof, it can be mentioned minoxidil, and the like.

Examples of the hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like.

Medicinal agents such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensation agents, warming sensation agents, wound healing promoters, irritation relaxation agents, analgesics, cell activators, etc. Derivatives such as tocopheryl acid, lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, hydroxycapric acid, α- or β-hydroxy acids and derivatives thereof (long-chain α-hydroxy fatty acids, long Chain α-hydroxy fatty acid cholesteryl, etc.), γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, ceramides, sphingosines, caffeine, xanthine, and derivatives thereof, coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, Catechins, flavones such as quercetin, isoflavones, gallic acid and ester sugar derivatives, tannins, sesamin, protoanthocyanidins, chlorogenic acid, polyphenols such as apple polyphenol, rutin and its derivatives, hesperidin and its derivatives, lignan glycosides Licorice extract-related substances (grabrizine, glabrene, liquiritin, isoliquiritin, etc.), lactoferrin, fragrance and derivatives thereof (shogaol, gingerol, menthol, camphor, cedrol, etc.), capsaicin and its derivatives, vanillin and its derivatives, insect repellent ( Diethyltoluamide and the like), complexes of physiologically active substances and cyclodextrins, and the like.

Examples of the plant / animal / microbe extracts include, for example, iris extract, ashitaba extract, asunalo extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract. Extract Steller's root extract, Ononis extract, Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed co Gye powder, hydrolyzed silk, cocoon extract, chamomile extract, oil-soluble chamomile extract, carrot extract, Chinese mugwort extract, oat extract, calcade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiou extract, jellyfish extract, quina extract, cucumber extract , Kiri leaf extract, guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract , Ginger pepper extract, black tea extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran extract, rice germ oil, ko Free extract, Collagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Soap extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Shinanoki Extract, Citrus extract, Jatoba extract, Peonies extract, Shokyu extract, Shobu root extract, Birch extract, White jellyfish extract, Horsetail extract, Stevia extract, Stevia fermented product, Nishikawa willow extract, Atlantic hawthorn extract, Atlantic hawthorn extract, Western elderberry extract, Achillea millefolium extract, mint extract, sage extract, mallow extract, nematode extract, assembly extract, Sakuhakuhi extract, die Pepper extract, soybean extract, tassium extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, green tea extract, red pepper extract, red spruce extract, red snapper extract, red spruce extract, spruce extract, dokudami extract , Tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, buckwheat extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, cypress extract, bisabolol, cypress extract, bifidobacteria Extract, loquat extract, dandelion extract, burdock extract, bukkake extract, butcher bloom extract, grape extract, grape seed extract, propolis Loofah extract, safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, marronnier extract, citrus extract, mugwort extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, Yuzu Extract, Lily Extract, Yokuinin Extract, Artemisia Extract, Lavender Extract, Green Tea Extract, Eggshell Membrane Extract, Apple Extract, Rooibos Tea Extract, Ganoderma Extract, Lettuce Extract, Lemon Extract, Forsythia Extract, Forsythia Extract, Rose Extract, Rosemary Extract, Rome Examples include chamomile extract, royal jelly extract, and bitumen extract.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like.

Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, and pyridoxine.

Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate.

Examples of the refreshing agent include menthol and methyl salicylate.

Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, and tannic acid.

Examples of the enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like.

Examples of the nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

Examples of the fragrances include acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-e super, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ -Undecalactone, estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate , Geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetive acetate Ril, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrsenol, jasmine absolute, jasmine lactone, cis-jasmon, Citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylus resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damolenone, thymol, tuberose absolute, decanal, decalactone, Terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-nonadienol, nonalactone, patchoulia Coal, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, perubalsum, vetiver oil, vetiverol , Peppermint oil, pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-ionone, lime oil , Lavender oil, D-limonene, linalool, rilal, lyial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, etc. it can.

Examples of the pigment / colorant / dye / pigment include brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red 104 -1, Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228 , Red 230-1, red 230-2, red 231, red 232, red 3, red 401, red 404, red 405, red 501, red 502, red 503, red 504, Red 505, Red 506, Orange 201, Orange 203, Orange 204, Orange 205, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201 Yellow 202-1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405 , Yellow 406, yellow 407, yellow 5 and other legal dyes; acid dyes such as Acid Red 14; Arianor Sienna Brown, Arianor Mad Red Basic dyes such as der Red), Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3,4-hydroxypropylamino- 3-nitrophenol (3,4-hydoxypropylamino-3-nitrophenol), N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine (N, N'-bis (2-hydroxyethyl)- Nitro dyes such as 2-nitro-p-phenylenediamine), HC Blue 2, Basic Blue 26; Disperse dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic reds such as iron oxide (= Bengala) and iron titanate Pigments; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and ocher; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet Pigment; Chrome oxide Inorganic green pigments such as chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, oxychloride Pearl pigments such as bismuth and fish scale foil; metal powder pigments such as aluminum powder, copper powder and gold; surface treatment inorganic and metal powder pigments; red 201, red 202, red 204, red 205, red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404, Red 3, Red 104, Red 106, Red 227, Red 230 No., Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Organic pigments such as zirconium, barium or aluminum lakes such as color 203, green 3 and blue 1; surface treatment organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine Natural pigments and dyes such as quercetin, crocin, chlorophyll, curcumin, cochineal, naphthoquinones (such as shikonin), bixin, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2 , 5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, etc. and their salts, etc. In dye Examples include intermediates and couplers; auto-oxidizing dyes such as indoline; dihydroxyacetone and the like.

Examples of the water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkali ion water, electrolytic acid ion water, ion water, and cluster water.

In addition to these, cosmetic ingredient standards, cosmetic ingredient-specific formulation standards, Japan Cosmetic Industry Association ingredient name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug ingredient standards, Japanese Pharmacopoeia, Pharmaceutical Additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to appropriately contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described.

The pH of the antibacterial composition of the present invention is preferably in the range of 3 to 10, for example. The pH can be adjusted using a known pH adjusting agent.

The antibacterial composition of the present invention can be used in the same manner as a normal external preparation for skin. The antibacterial composition of the present invention is highly safe against skin and the like and can exhibit an excellent antibacterial action. Furthermore, it is excellent in storage stability.

Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited to these examples.

Synthesis Example 1 [Synthesis of N-methyl-N- (2,3-dihydroxypropyl) lauric acid amide (= compound 1a) by the Schotten-Baumann method]
3- (N-methylamino) -1,2-propanediol was added to a 1 L four-necked flask equipped with a reflux pipe equipped with a nitrogen inlet line with a three-way cock switching and a vent line, a thermometer, and two 200 mL dropping funnels. 78.85 g (0.75 mol) and 100 mL of ethanol were added. In the dropping funnel, 164.08 g (0.75 mol) of lauric acid chloride was added. 14 g (0.75 mol) was added, and the inside of the reactor was replaced with a nitrogen atmosphere.
After cooling to 0 ° C. with stirring, lauric acid chloride was slowly added dropwise so that the reaction temperature did not deviate from the range of 0 ° C. to 8 ° C. At the stage where half of the total amount of lauric acid chloride was dropped, the aqueous sodium hydroxide solution was started to be dropped. Thereafter, the reaction temperature was not deviated from the range of 0 ° C. to 10 ° C., and the remaining lauric acid was dropped. After completing the addition of both components while adjusting the dropping rate so that the addition of the aqueous sodium hydroxide solution is completed at the same time, the pH is adjusted to a range of 7-8 using a small amount of 28% aqueous sodium hydroxide solution. The mixture was further stirred for 1 hour at 0 ° C. to 5 ° C., heated to room temperature and stirred for 1 hour, and then concentrated on a rotary evaporator. 550 mL of acetone was added to the residue, heated and stirred at 45 ° C., and filtered through filter paper to obtain a transparent solution. The obtained clear solution is left overnight in a refrigerator at −5 ° C., and the precipitated white crystals are filtered and washed with a G4 glass filter to obtain N-methyl-N- (2,3-dihydroxypropyl) lauric acid. 169.16 g of amide was obtained (yield: 78.5%).
The obtained white crystalline substance was confirmed to have the desired structure by ¹ H-NMR, ¹³ C-NMR and IR spectrum.

Synthesis Example 2 [Synthesis of Compound 1a by Transesterification Method]
Into a 1 L four-necked flask with a reflux pipe equipped with a nitrogen introduction line with a three-way cock switching, a thermometer with a sheath pipe, and a three-way cock for switching between a vent line and a vacuum pump vacuum line, 321.52 g of methyl laurate ( 1.55 mol), 3- (N-methylamino) -1,2-propanediol (manufactured by Daicel Corporation) 157.70 g (1.50 mol) was added, and the internal temperature was increased to 70 ° C. The inside of the reactor was purged with nitrogen while stirring. To this was added 3.377 g (0.015 mol) of a 28% sodium methoxide methanol solution, the internal temperature was raised to 110 ° C., and the distillate state was monitored so that methanol would not suddenly boil up to 600 mmHg. The pressure was reduced. Thereafter, the pressure was gradually reduced to 30 mmHg while maintaining 110 ° C., and after 40 hours, the residual methyl methyl laurate was confirmed to be 0.1% or less by GC analysis, and then cooled to 80 ° C. to be inorganic. After adding 21.6 g of a synthetic adsorbent (trade name “KYOWARD 700”, manufactured by Kyowa Chemical Industry Co., Ltd.) and stirring for 3 hours, the filtrate was cooled by filtration through a G4 glass filter, and 413.12 g of light A yellowish white waxy product was obtained. To this was added 826.27 g of methanol and heated to 50 ° C. to make a homogeneous solution, then left standing overnight in a refrigerator at −5 ° C., and the precipitated white crystals were filtered off with a G4 glass filter to a constant value at room temperature. After drying under reduced pressure, the residue was further recrystallized from acetone to obtain 294.92 g of N-methyl-N- (2,3-dihydroxypropyl) lauric acid amide (yield: 68.4%).
The obtained white crystalline substance was confirmed to have the desired structure by ¹ H-NMR, ¹³ C-NMR and IR spectrum (FIGS. 1 to 3).

[Minimum growth inhibitory concentration evaluation method]
About the compound 1a obtained by the said synthesis example, the antibacterial property (minimum growth inhibitory concentration: MIC) with respect to general bacteria and fungi was evaluated by the following method.
Test strains: The bacteria described in Table 1 were used.
Preparation of test bacterial solution: The test bacterial strain was pre-cultured to prepare a test bacterial solution having a bacterial count of 10 ^{5 to 6} cells / mL.
Test procedure: Bouillon medium (however, GP medium in the case of fungi, potato dextrose agar medium in the case of mold) 9 mL of compound 1a and purified water (sterilized) were added (total). : 10 mL). Thereto, 100 μL of the test bacterial solution was added and stirred with a mixer. When general bacteria were added, the cells were cultured in an incubator at 32 ° C. for 24 hours, and when fungi were added, they were cultured at 25 ° C. for 24 hours.
The turbidity of the test tube containing the cultured sample and the test tube containing purified water was visually observed and evaluated according to the following criteria.
Visual judgment criteria Medium is not turbid: Antibacterial is present Medium is turbid: Not antibacterial After visual judgment, 1 mL of a sample in which the medium is not turbid is taken in a petri dish and pour plate test (SCD, SCDLP, potato dextrose) Agar medium, 20 mL each). In the case of general bacteria, it was cultured in an incubator at 32 ° C. for 24 hours, and in the case of fungi at 25 ° C. for 24 hours, and antibacterial properties were determined from the presence or absence of colony growth. The results are shown in Table 1.

As shown in Table 1, Compound 1a had antibacterial properties against general bacteria and fungi. In addition, the antibacterial properties of Compound 1a did not change due to changes in pH or heating. Furthermore, the antibacterial properties of Compound 1a were not limited to the test bacteria used for the evaluation.

Examples 1 to 5
An aqueous solution of the compound 1a obtained in the synthesis example (sometimes referred to as “VK-3001”) and an antibacterial compound (methylparaben, phenoxyethanol, 1,3-propanediol, 1,2-pentanediol, or ε-polylysine) Were mixed to obtain an antibacterial composition.
About the obtained antibacterial composition, antibacterial property was evaluated by the following method.
[Antimicrobial test method]
As the test bacteria and culture medium, the same antimicrobial activity as that used in [Minimum Growth Inhibitory Concentration Evaluation Method] was used, and antibacterial properties were determined according to the following criteria.
(Criteria)
◎: Antiseptic effect is sufficiently strong ○: Antiseptic effect is strong ×: Antiseptic effect is weak

As shown in Tables 2 to 6, an antibacterial composition comprising a combination of Compound 1a and an antibacterial compound (methylparaben, phenoxyethanol, 1,3-propanediol, 1,2-pentanediol, ε-polylysine) has antibacterial properties. It has been shown that excellent antibacterial action is exhibited even when the amount of the active compound used is reduced.

Example 6 (whitening lotion)
The raw materials belonging to the following x were heated to 70 ° C. and completely dissolved, and then cooled to room temperature. Thereafter, raw materials belonging to the following y were mixed to obtain a whitening lotion (pH: 6.5).

* 1 Ferriox 115A: Hydroxyethane diphosphonic acid solution (manufactured by Lion Corporation)
* 2 EM protein-L: Hydrolyzed egg diaphragm aqueous solution (manufactured by Kewpie Co., Ltd.)
* 3 Chitocatalyzer W: Yeast extract (manufactured by Yamakawa Trading Co., Ltd.)

Example 7 (milky lotion)
After the raw material belonging to the following x (oil phase part) and the raw material belonging to the following y (aqueous phase part) are heated to 70 ° C. and completely dissolved, the oil phase part is mixed with the aqueous phase part and emulsified by an emulsifier. Emulsified. The obtained emulsion was cooled to 30 ° C. to obtain an emulsion (pH: 5.0).

* 4 1,3-propanediol: Zemea Select Propanediol (DuPont Tail & Lyle)
* 5 MFP: Fermentation conversion product (BST, Korea)

Example 8 (moisture cream)
After the raw material belonging to the following x (oil phase part) and the raw material belonging to the following y (aqueous phase part) are heated to 70 ° C. and completely dissolved, the oil phase part is mixed with the aqueous phase part and emulsified by an emulsifier. Emulsified. The obtained emulsion was cooled to 30 ° C. to obtain a moisture cream (pH: 7.0).

Example 9 (face washing cream)
After the raw material belonging to the following x (oil phase part) and the raw material belonging to the following y (aqueous phase part) are heated to 75 ° C. and dissolved, the aqueous phase part is slowly mixed with the oil phase part, and then well After stirring, it was cooled to 30 ° C. to obtain a face-washing cream (pH: 8.5).

Example 10 (sunscreen cream)
After the raw material belonging to the following x (oil phase part) and the raw material belonging to the following y (aqueous phase part) are heated to 75 ° C. and completely dissolved, the oil phase part is mixed with the aqueous phase part and emulsified by an emulsifier. Emulsified. The obtained emulsion was cooled to 30 ° C. to obtain a sunscreen cream (pH: 6.0).

Example 11 [Liquid Foundation (Shake Well Type)]
The raw material (oil phase part) belonging to the following x was heated to 60 ° C. and then cooled to room temperature. Then, the raw material (oil phase part) belonging to the following x and the raw material (aqueous phase part) belonging to the following y were mixed at room temperature and emulsified with an emulsifier to obtain a shake well type liquid foundation.

Example 12 (Shampoo)
The following raw materials were heated to 80 ° C. and then cooled to room temperature to obtain a shampoo.

Example 13 (conditioner)
The raw materials (oil phase part) belonging to the following x and y are heated to 80 ° C., the raw materials belonging to the following z heated to 80 ° C. are mixed at 80 ° C., emulsified with an emulsifier, and then to room temperature. A conditioner was obtained after cooling.

Example 14 (sun lotion)
The raw material (oil phase part) belonging to the following x was heated to 80 ° C., the raw material belonging to the following y heated to 80 ° C. was mixed at 80 ° C., emulsified with an emulsifier, and then cooled to room temperature. . Then, the raw material which belongs to the following z was added and the sun lotion was obtained.

Example 15 (moisture cream)
The raw material belonging to x below (oil phase part) is heated to 80 ° C., the raw material belonging to y below heated to 80 ° C. is mixed at 80 ° C., emulsified with an emulsifier, and then cooled to room temperature. did. Thereafter, a raw material belonging to z below was added to obtain a moisture cream.

Example 16 (Balancing Toner)
The raw material belonging to the following x (oil layer part) was added to the raw material belonging to the following y, and after stirring, the raw material belonging to the following z was added to obtain a balancing toner.

The “antiseptic effect” of the skin external preparations obtained in Examples 6 to 16 was evaluated by the above antibacterial test.

In addition, sensory evaluation was performed on the “appearance” and “odor” of the external preparations for skin obtained in Examples 6 to 16 above.
3. Female panelists (5 to 10 persons) use the external preparation for skin obtained in Examples 6 to 16 in the usual usage method, 5: very good Good, 3. Usually 2. Somewhat bad. Evaluation was made on a five-point scale. The total score evaluated was divided by the number of panelists to give a score, which was evaluated according to the following criteria. Furthermore, the presence or absence of a feeling of irritation was also confirmed, and the result was displayed as a percentage (ratio of panelists who performed the evaluation in all panelists).
(Sensory evaluation criteria)
◎: Over 4.5 points, 5.0 points or less ○: Over 3.5 points, 4.5 points or less △: Over 2.5 points, 3.5 points or less ×: 2.5 points or less

The above results are summarized in the following table.

It was found that the external preparations for skin obtained in Examples 6 to 16 were excellent in antiseptic effect, appearance and smell, and had no irritation and safety.

The antibacterial composition of the present invention has a high antibacterial action against bacterial species such as bacteria, molds and yeasts that cause contamination of the external preparation for skin, and can exhibit a sufficient antiseptic effect. Furthermore, in the antibacterial composition of the present invention, the amount of the antibacterial compound such as paraben used can be reduced as compared with the conventional one, which is excellent in terms of safety.

Claims (4)

1. An antibacterial composition containing the following component (A) and component (B).
   Component (A): Compound represented by the following formula (1)
   

   

   (Wherein R represents a linear or branched alkyl or alkenyl group having 5 to 21 carbon atoms)
   Ingredient (B): Antibacterial compound
2. Component (B) is paraoxybenzoic acid ester and its salt, phenoxyethanol, benzoic acid and its salt, salicylic acid and its salt, sorbic acid and its salt, dehydroacetic acid and its salt, polylysine, 1,3 having 3 to 5 carbon atoms The antibacterial composition according to claim 1, comprising at least one antibacterial compound selected from alkanediol and 1,2-alkanediol having 5 to 12 carbon atoms.
3. The antibacterial composition according to claim 1 or 2, comprising 0.001 to 10% by weight of component (A) and 0.01 to 20% by weight of component (B) in the total amount (100% by weight) of the antibacterial composition. object.
4. The antibacterial composition according to any one of claims 1 to 3, which is used as an external preparation for skin.

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