JPWO2018221337A1 - Antimicrobial composition - Google Patents

Abstract

An object of the present invention is to provide an antibacterial composition that exhibits high antibacterial properties even in an emulsion system and has high antibacterial properties against mold. In order to solve the above problems, the present invention provides an antibacterial composition containing a diol compound represented by the following general formula (1) as a component (A) and benzyloxyethanol as a component (B). (In the formula, R1 represents an alkyl group having 3 to 8 carbon atoms.)

Description

  The present invention relates to an antibacterial composition that can be used for cosmetics and the like.

  Antibacterial agents (preservatives) are often used in cosmetics and the like for the purpose of preservation. Parabens are most used as antibacterial agents for cosmetics and the like, but parabens are highly irritating to the skin, and their use concentration in cosmetics is limited to 1% by mass or less. Recently, an increasing number of people have an allergic reaction to parabens, and the demand for cosmetics not containing parabens is increasing. It is known that a high antibacterial property can be obtained by using a combination of parabens and benzyloxyethanol (for example, see Patent Documents 1 and 2). However, although the use amount of parabens can be reduced, allergy due to parabens is known. The reaction cannot be eliminated.

On the other hand, alkanediol compounds such as 1,2-octanediol have high antibacterial properties and are also highly safe for the human body as compared with parabens. (For example, see Patent Documents 3 and 4). However, alkanediol compounds may have reduced antibacterial properties in emulsified cosmetics. Further, it has high antibacterial properties against bacteria, but has insufficient antibacterial properties against fungi such as mold.
Therefore, there is a demand for the development of an antibacterial agent which exhibits high antibacterial properties even in an emulsified system, is effective not only for bacteria but also for fungi, and can be incorporated in cosmetics and the like.

JP-A-2005-2325205 Japanese Patent Application Laid-Open No. 2005-232520 JP-A-11-325991 JP 2001-048720 A

  Then, the present inventors diligently studied, and found that the alkanediol compound has a synergistic effect with benzyloxyethanol and antibacterial properties, and reached the present invention. That is, the present invention is an antibacterial composition containing a diol compound represented by the following general formula (1) as the component (A) and benzyloxyethanol as the component (B).

(In the formula, R ¹ represents an alkyl group having 3 to 8 carbon atoms.)

  The effect of the present invention is to provide an antibacterial composition which exhibits high antibacterial properties even in an emulsified system and has high antibacterial properties against fungi such as mold.

The diol compound represented by the general formula (1), which is the component (A) of the present invention, will be described. In the general formula (1), R ¹ represents an alkyl group having 3 to 8 carbon atoms. Examples of the alkyl group having 3 to 8 carbon atoms include propyl, isopropyl, butyl, isobutyl, secondary butyl, t-butyl, pentyl, isopentyl, secondary pentyl, t-pentyl, and hexyl. Groups, secondary hexyl group, heptyl group, secondary heptyl group, octyl group, secondary octyl group, 2-methylpentyl group, 2-ethylhexyl group and the like. R ¹ is preferably a propyl group, a butyl group, a pentyl group, a hexyl group, a heptyl group, more preferably a pentyl group, a hexyl group, and most preferably a hexyl group because of its high antibacterial properties. Preferred specific examples of the diol compound represented by the general formula (1) include, for example, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 2-nonanediol and the like.

The component (B) of the present invention is benzyloxyethanol.
Generally, the ratio of the component (A) to the component (B) is not particularly limited, but the ratio of the component (A) to the component (B) is preferably from 10:90 to 90:10 by mass, : 80-80: 20, more preferably 30: 70-70: 30. When the mass ratio of the component (A) to the component (B) is extremely large, the effect of improving the antibacterial property of the component (A) by the component (B) may be small, and the mass ratio may be extremely small. In such a case, the antibacterial property of the component (A) may decrease.

  The amount of the antibacterial composition of the present invention is not particularly limited because it varies depending on the intended use.If the amount is too small, the antibacterial effect may be low.If the amount is too large, the effect of increasing the amount corresponding to the added amount is obtained. In some cases, the total amount of the component (A) and the component (B) is preferably 0.001 to 10% by mass, more preferably 0.01 to 3% by mass, based on the total amount of the compounded product. , 0.1 to 2% by mass.

  Since the antibacterial composition of the present invention has an enhanced antibacterial effect, it further includes a chelating agent, a low-molecular polyol (however, excluding the diol compound corresponding to the component (A)), and a nitrogen-containing nonionic surfactant as the component (C). It is preferable to contain one or more compounds selected from the group consisting of an agent, a nitrogen-containing amphoteric surfactant, a plant-derived extract, and a zinc compound.

  As the chelating agent, for example, amino polycarboxylic acid chelating agent, aromatic or aliphatic carboxylic acid chelating agent, amino acid chelating agent, ether polycarboxylic acid chelating agent, phosphonic acid chelating agent, phosphoric acid chelating agent, Examples include hydroxycarboxylic acid-based chelating agents, polymer electrolyte (including oligomer electrolyte) -based chelating agents, dimethylglyoxime, ascorbic acid, thioglycolic acid, phytic acid, glyoxylic acid, glyoxalic acid, and the like. Each of these chelating agents may be in a free acid form or in a salt form such as a sodium salt, a potassium salt, and an ammonium salt. In addition, they may be in the form of their hydrolyzable ester derivatives.

  Examples of the aminopolycarboxylic acid chelating agent include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, and N- (2 -Hydroxyethyl) ethylenediaminetriacetic acid, glycoletherdiaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid and salts thereof.

  Examples of the aromatic or aliphatic carboxylic acid chelating agent include, for example, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvic acid, salicylic acid, Examples include acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranilic acid), phthalic acid, fumaric acid, trimellitic acid, gallic acid, hexahydrophthalic acid, and salts, methyl esters and ethyl esters thereof.

Examples of the amino acid chelating agent include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts and derivatives thereof.
Examples of the hydroxycarboxylic acid-based chelating agent include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartaric acid, lactic acid and salts thereof.

Examples of the phosphonic acid-based chelating agent include iminodimethylphosphonic acid, alkyl diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof.
Examples of the phosphoric acid chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, and polyphosphoric acid.

  Examples of the polymer electrolyte (including an oligomer electrolyte) chelating agent include acrylic acid polymer, maleic anhydride polymer, α-hydroxyacrylic acid polymer, itaconic acid polymer, and two kinds of constituent monomers of these polymers. Copolymers and epoxy succinic acid polymers comprising the above are mentioned.

  Among these chelating agents, ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid, succinic acid, salicylic acid, oxalic acid, lactic acid , Fumaric acid, citric acid, tartaric acid, 1-hydroxyethane-1,1-diphosphonic acid and salts thereof are preferred, ethylenediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, glutamic acid Acetic acid, aspartic diacetic acid, succinic acid, lactic acid, tartaric acid and salts thereof are more preferred, and ethylenediaminetetraacetic acid, glutamic diacetic acid, aspartic diacetic acid and salts thereof are most preferred.

  The amount of the chelating agent is not particularly limited. However, when the amount of the chelating agent is too small, the effect of improving the antibacterial property may not be obtained in some cases. When the amount is too large, the antibacterial property cannot be improved in proportion to the added amount. The amount is preferably 0.5 to 500 parts by mass, more preferably 1 to 200 parts by mass, still more preferably 2 to 100 parts by mass, and particularly preferably 10 to 75 parts by mass with respect to 100 parts by mass of the component.

  Examples of the low molecular polyol (however, diol compounds corresponding to the component (A) are excluded) include, for example, ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3 -Propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, 2-methyl-1,2-propanediol, 2-methyl-1,3 -Propanediol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2-methyl-1,2-butanediol, 2-methyl-2,3-butanediol, 2-methyl-1,4 Butanediol, 3-methyl-1,3-butanediol, 2-ethyl-1,3-propanediol, 2,2-dimethyl-1,3-propanediol, 1,5-hexanediol, 1,6-hexanediol , 2,5-hexanediol, 3,3-hexanediol, 2-methyl-1,3-pentanediol, 2-methyl-1,5-pentanediol, 2-methyl-2,4-pentanediol, 3- Methyl-1,5-pentanediol, 3-methyl-2,3-pentanediol, 3-methyl-2,4-pentanediol, 2-ethyl-2-methyl-1,3-propanediol, 2,2- Dimethyl-2,4-butanediol, 1,7-heptanediol, 3,4-heptanediol, 2-propyl-2-methyl-1,3-propanediol, 2- Sopropyl-2-methyl-1,3-propanediol, 1,8-octanediol, 3,6-octanediol, 2-ethyl-1,3-hexanediol, 2-sec-butyl-2-butyl-1, 3-propanediol, 2,2-dimethyl-1,3-hexanediol, 2,5-dimethyl-2,5-hexanediol, 2,2,4-trimethyl-1,3-pentanediol, 1,3- Nonanediol, 1,9-nonanediol, 3,6-octanediol, 2-ethyl-2- (2-methyl) propyl-1,3-propanediol, 2,2,4-trimethyl-1,6-hexane Diol, 2,4,4-trimethyl-1,6-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 2,4-diethyl-1,5-pentanedio 2-methyl-1,8-octanediol, 1,10-decanediol, 5,6-decanediol, 3,6-dimethyl-3,6-octanediol, 3,7-dimethyl-1,6- Octanediol, 3,7-dimethyl-1,7-octanediol, 1,2-undecanediol, 1,4-undecanediol, 1,11-undecanediol, 6-ethyl-3-methyl-1,6-octane Diol, 1,2-dodecanediol, 1,10-dodecanediol, 1,12-dodecanediol, 2,4-diethyl-1,5-octanediol, 2,8,8-trimethyl-2,7-nonanediol , 1,2-tetradecanediol, 1,14-tetradecanediol, 7,8-tetradecanediol, 1,2-pentadecanediol, Sadecandiol, 1,16-hexadecanediol, 1,17-heptadecanediol, 1,2-octadecanediol, 1,12-octadecanediol, 1,2-eicosanediol, 1,2-docosandiol, Saturated diols or condensates thereof, such as 2,2-tetracosanediol;

  2-butene-1,4-diol, 3-butene-1,2-diol, 2-methylene-1,3-propanediol, 2-butyne-1,4-diol, 5-hexene-1,2-diol , 3-methyl-2-pentene-1,5-diol, 3-methylenepentane-1,5-diol, 1,5-hexadiene-3,4-diol, 7-octene-1,2-diol, 2, 5-dimethyl-3-hexene-2,5-diol, 9-decene-1,2-diol, 2,6-dimethyl-7-octene-2,6-diol, 3,7-dimethyl-7-octene- 1,6-diol, 13-tetradecene-1, 2-diol, 12-hydroxy-9-octadecenol, 2-pentyne-1,4-diol, 3-hexyne-2,5-diol, 4-methyl-2- Pentin- , 4-diol, 3-heptin-2,5-diol, 4-methyl-2-pentyne-1,4-diol, 3,4-dimethyl-1-pentyne-3,4-diol, 2,5-dimethyl -3-hexyne-2,5-diol, 5-decyne-4,7-diol, 2,6-dimethyl-7-octin-2,6-diol, 3,6-dimethyl-4-octyne-3,6 -Diol, 2,3,6,7-tetramethyl-4-octyne-3,6-diol, 2,4,7,9-tetramethyl-5-decyne-4,7-diol, 2,5,8 , 11-Tetramethyl-6-dodecine-5,8-diol, 1,1,4,4-tetraisopropyl-4-octyne-3,6-diol, 5,10-diethyl-7-tetradecine-6,9 Unsaturated diols such as diols;

  1,2-cyclopentanediol, 1,3-cyclopentanediol, 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2-cycloheptanediol, 2,3-norbornane Diol, 2,5-norbornanediol, 2,7-norbornanediol, 1,2-cyclooctanediol, 1,4-cyclooctanediol, 1,2-cyclodecanediol, 5-cyclooctene-1,2-diol Alicyclic diols such as 1,5-decalindiol, limonene glycol, 1,2-terpenediol, 4,4'-bicyclohexanediol, and 1,2-cyclododecanediol;

  Glycerin, 1,2,3-butanetriol, 1,2,4-butanetriol, 2-methyl-1,2,3-propanetriol, 1,2,3-pentanetriol, 1,2,4-pentanetriol 1,3,5-pentanetriol, 2,3,4-pentanetriol, 2-methyl-2,3,4-butanetriol, trimethylolethane, 2,3,4-hexanetriol, 2-ethyl-1 , 2,3-butanetriol, trimethylolpropane, 4-propyl-3,4,5-heptanetriol, 2,4-dimethyl-2,3,4-pentanetriol, triethanolamine, triisopropanolamine, etc. Polyhydric alcohol;

  Erythritol, pentaerythritol, 1,2,3,4-pentatetrol, 2,3,4,5-hexatetrol, 1,2,4,5-pentanetetrol, 1,3,4,5-hexane Tetrahydric alcohols such as tetrol, diglycerin, sorbitan, N, N, N ', N'-tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N', N'-tetrakis (hydroxyethyl) ethylenediamine;

Pentahydric alcohols such as adonitol, arabitol, xylitol, triglycerin;
Hexahydric alcohols such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, dalcitol, talose, allose;

  1-methyl glyceryl ether, 2-methyl glyceryl ether, 1-ethyl glyceryl ether, 2-ethyl glyceryl ether, 1-propyl glyceryl ether, 2-propyl glyceryl ether, 1-isopropyl glyceryl ether, 2-isopropyl glyceryl ether, 1- Butyl glyceryl ether, 2-butyl glyceryl ether, 1-isobutyl glyceryl ether, 2-isobutyl glyceryl ether, 1-pentyl glyceryl ether, 2-pentyl glyceryl ether, 1-hexyl glyceryl ether, 2-hexyl glyceryl ether, 1-heptyl glyceryl Ether, 2-heptyl glyceryl ether, 1-octyl glyceryl ether, 2-octyl glyceryl ether, 1- (2-ethylhexyl) Lyseryl ether, 2- (2-ethylhexyl) glyceryl ether, 1-nonyl glyceryl ether, 2-nonyl glyceryl ether, 1-decyl glyceryl ether, 2-decyl glyceryl ether, 1-undecyl glyceryl ether, 2-undecyl glyceryl Ether, 1-dodecyl glyceryl ether, 2-dodecyl glyceryl ether, 1-tridecyl glyceryl ether, 2-tridecyl glyceryl ether, 1-tetradecyl glyceryl ether, 2-tetradecyl glyceryl ether, 1-hexadecyl glyceryl ether, 2 -Hexadecyl glyceryl ether, 1-octadecyl glyceryl ether, 2-octadecyl glyceryl ether, 1-branched octadecyl glyceryl ether, 2-branched octadecyl glyceryl Ryl ether, 1-eicosyl glyceryl ether, 2-eicosyl glyceryl ether, 1-allyl glyceryl ether, 2-allyl glyceryl ether, 1-undecenyl glyceryl ether, 2-undecenyl glyceryl ether, 1-oleyl glyceryl ether, Glycerin monoethers such as 2-oleyl glyceryl ether, 2-cyclohexyl glyceryl ether, 2-phenyl glyceryl ether;

  N-substituted diethanolamines such as N-methyldiethanolamine, N-ethyldiethanolamine, N-propyldiethanolamine, N-isopropyldiethanolamine, N-butyldiethanolamine, N-cyclohexyldiethanolamine, N- (2-ethylhexyl) diethanolamine;

  N-methyldiisopropanolamine, N-ethyldiisopropanolamine, N-propyldiisopropanolamine, N-isopropyldiisopropanolamine, N-butyldiisopropanolamine, N-cyclohexyldiisopropanolamine, N- (2-ethylhexyl) diamine N-substituted diisopropanolamines such as isopropanolamine;

  3-dimethylamino-1,2-propanediol, 3-diethylamino-1,2-propanediol, 3-dipropylamino-1,2-propanediol, 3-diisopropylamino-1,2-propanediol, 3- N, N-disubstituted-3-amino-1,2-propanediols such as dibutylamino-1,2-propanediol.

  Among these low molecular polyols, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,2-butanediol, 1,3-butanediol, 2,3-butanediol, 3 -Methyl-1,3-butanediol, 2-ethyl-1,3-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 1,10-decanediol, glycerin, triethanolamine, triisopropanol Amine, erythritol, diglycerin, sorbitan, N, N, N ', N'-tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N', N'-tetrakis (hydroxyethyl) ethylenediamine, sorbitol, 1-methyl Glycerylue Ter, 1-ethyl glyceryl ether, 1-propyl glyceryl ether, 1-butyl glyceryl ether, 1-allyl glyceryl ether are preferred, and ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 3-butanediol, 3-methyl-1,3-butanediol, glycerin, triethanolamine, diglycerin, sorbitan, N, N, N ', N'-tetrakis (2-hydroxypropyl) ethylenediamine, sorbitol, 1-allyl Glyceryl ether is more preferred, and propylene glycol, dipropylene glycol, 1,3-butanediol, 3-methyl-1,3 butanediol, glycerin, sorbitol, 1-allyl glycol Glyceryl ether is more preferable.

  The blending amount of the low-molecular polyol is not particularly limited, but if the low-molecular polyol is too small, the antibacterial property improving effect may not be obtained.If the low-molecular polyol is too large, the antibacterial property corresponding to the added amount may not be obtained. The amount of the low-molecular polyol is preferably 0.5 to 500 parts by mass, more preferably 1 to 200 parts by mass, still more preferably 2 to 100 parts by mass, and preferably 10 to 100 parts by mass, per 100 parts by mass of the component (A). 75 parts by weight are particularly preferred.

  Examples of the nitrogen-containing nonionic surfactant include compounds represented by the following general formulas (2) to (8).

(Wherein, R ² represents an alkyl group or an alkenyl group, R ³ represents an alkyl group, an alkenyl group, or a group represented by — (CH ₂ CH ₂ O) _b —H, and a and b represent 1 to 20 respectively. Represents the number of

(In the formula, R ⁴ represents an alkyl group or an alkenyl group, c, d, and e each represent a number of 1 to 20, and f represents a number of 2 to 3.)

(In the formula, R ⁵ represents an alkyl group or an alkenyl group.)

(Wherein, R ⁶ represents an alkyl or alkenyl group, R ⁷ is a hydrogen atom, an alkyl group or 1 to 4 carbon atoms - represents (R ⁹ O) a group represented by _h -H, R ⁸ and R ⁹ represents an alkylene group having 2 to 3 carbon atoms, and g and h each independently represent a number of 1 to 20.)

(In the formula, R ¹⁰ and R ¹¹ represent an ethylene group or a propylene group, and j and k each independently represent a number of 1 to 200. However, R ¹⁰ and R ¹¹ are not the same group. )

(In the formula, R ¹² represents an alkyl group or an alkenyl group.)

(In the formula, R ¹³ represents an alkyl group or an alkenyl group, and m represents a number of 2 or 3.)

In the general formula (2), R ² represents an alkyl group or an alkenyl group, R ³ represents an alkyl group, an alkenyl group or a group represented by — (CH ₂ CH ₂ O) _b —H, and a and b each represent Represents a number from 1 to 20. R ² is preferably an alkyl group or alkenyl group having 8 to 22 carbon atoms, and more preferably an alkyl group or alkenyl group having 12 to 18 carbon atoms. R ³ is preferably a group represented by — (CH ₂ CH ₂ O) _b —H. As for a and b, the total value of a and b is preferably a number of 2 to 10, and more preferably a number of 2 to 4.

In the general formula (3), R ⁴ represents an alkyl group or an alkenyl group, c, d and e each represent a number of 1 to 20, and f represents a number of 2 to 3. R ⁴ is preferably an alkyl group or alkenyl group having 8 to 22 carbon atoms, more preferably an alkyl group or alkenyl group having 12 to 18 carbon atoms. As for c, d and e, the total value of c, d and e is preferably a number of 3 to 10, more preferably a number of 3 to 5. Further, f is preferably a number of 2 to 3, more preferably 3.

In the general formula (4), R ⁵ represents an alkyl group or an alkenyl group. R ⁵ is preferably an alkyl group or alkenyl group having 8 to 22 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 18 carbon atoms, and still more preferably an alkyl group or alkenyl group having 10 to 14 carbon atoms.

In the general formula (5), R ⁶ represents an alkyl group or an alkenyl group; R ⁷ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group represented by — (R ⁹ O) _h —H; ⁸ and R ⁹ each represent an alkylene group having 2 to 3 carbon atoms, and g and h each independently represent a number of 1 to 20. R ⁶ is preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 17 carbon atoms, and still more preferably an alkyl group having 11 to 13 carbon atoms. R ⁷ is preferably a hydrogen atom, a methyl group, or —CH ₂ CH ₂ OH, and more preferably a hydrogen atom or a methyl group. When R ⁷ is a hydrogen atom, g is preferably a number of 1 to 3, and more preferably R ⁸ is an ethylene group and g is 1. When R ⁷ is a methyl group, R ⁸ is preferably an ethylene group, and more preferably, R ⁸ is an ethylene group and g is 1. When R ⁷ is —CH ₂ CH ₂ OH, it is preferred that R ⁸ is an ethylene group and g is 1. H is preferably 1.

In the general formula (6), R ¹⁰ and R ¹¹ represent an ethylene group or a propylene group, and j and k are not 0 but each represent an independent number of 1 to 200. Preferably, R ¹⁰ is a propylene group and R ¹¹ is an ethylene group. Further, j is preferably a number of 7 to 25, more preferably a number of 10 to 15, and still more preferably a number of 11 to 13. Furthermore, the value of j is preferably from 10 to 200%, more preferably from 20 to 150%, even more preferably from 50 to 100%, based on the value of k.

In the general formula (7), R ¹² represents an alkyl group or an alkenyl group. R ¹² is preferably an alkyl group or alkenyl group having 9 to 18 carbon atoms, more preferably an alkyl group having 10 to 16 carbon atoms, and still more preferably an alkyl group having 10 to 14 carbon atoms.

In the general formula (8), R ¹³ represents an alkyl group or an alkenyl group, and m represents a number of 2 or 3. R ¹³ is preferably an alkyl group or alkenyl group having 8 to 17 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and still more preferably an alkyl group having 9 to 13 carbon atoms. Further, m is preferably a number of 3.

  Among these nitrogen-containing nonionic surfactants, the compounds represented by formulas (2), (4), (5) and (7) are preferable, and the compounds represented by formulas (2), (5) and (7) are preferred. Is more preferable, and the general formula (5) is most preferable.

  The amount of the nitrogen-containing nonionic surfactant is not particularly limited, but if the amount of the nitrogen-containing nonionic surfactant is too small, the effect of improving the antibacterial properties may not be obtained.If the amount is too large, the effect of increasing the amount to meet the amount is obtained. Therefore, the compounding amount of the nitrogen-containing nonionic surfactant is preferably 0.5 to 500 parts by mass, more preferably 1 to 200 parts by mass, and more preferably 2 to 100 parts by mass with respect to 100 parts by mass of the component (A). Even more preferred is 10 to 75 parts by weight.

  Examples of the nitrogen-containing amphoteric surfactant include compounds represented by the following general formulas (9) to (14):

(R ¹⁴ represents an alkyl group, and n represents a number of 1 to 3.)

(R ¹⁵ represents an alkyl group or an alkenyl group, and p represents a number of 2 to 3.)

(R ¹⁶ represents an alkyl group or an alkenyl group, and q represents a number of 2 to 3.)

(R ¹⁷ represents an alkyl group or an alkenyl group.)

(R ¹⁸ represents an alkyl group or an alkenyl group, and r represents a number of 2 to 3.)

(R ¹⁹ represents an alkyl group or an alkenyl group, and s represents a number of 2 to 3.)

In the general formula (9), R ¹⁴ represents an alkyl group, and n represents a number of 1 to 3. R ¹⁴ is preferably an alkyl group having 9 to 18 carbon atoms, more preferably an alkyl group having 10 to 16 carbon atoms, and still more preferably an alkyl group having 10 to 14 carbon atoms. Further, the value of n is preferably 1.

In the general formula (10), R ¹⁵ represents an alkyl group or an alkenyl group, and p represents a number of 2 to 3. R ¹⁵ is preferably an alkyl group or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and still more preferably an alkyl group having 9 to 13 carbon atoms. Further, p is preferably a number of 3.

In the general formula (11), R ¹⁶ represents an alkyl group or an alkenyl group, and q represents a number of 2 to 3. R ¹⁶ is preferably an alkyl group or alkenyl group having 7 to ²¹ carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and still more preferably an alkyl group having 9 to 13 carbon atoms. Also, q is preferably a number of 3.

In the general formula (12), R ¹⁷ represents an alkyl group or an alkenyl group, preferably an alkyl group or an alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl group or an alkenyl group having 9 to 15 carbon atoms, and more preferably 9 carbon atoms. ~ 13 alkyl groups are more preferred.

In the general formula (13), R ¹⁸ represents an alkyl group or an alkenyl group, and r represents a number of 2 to 3. R ¹⁸ is preferably an alkyl group or alkenyl group having 8 to ¹⁸ carbon atoms, more preferably an alkyl group or alkenyl group having 10 to 16 carbon atoms, and still more preferably an alkyl group having 10 to 14 carbon atoms. R is preferably a number of 3.

In the general formula (14), R ¹⁹ represents an alkyl group or an alkenyl group, and s represents a number of 2 to 3. R ¹⁹ is preferably an alkyl group or alkenyl group having 7 to ²¹ carbon atoms, more preferably an alkyl group or alkenyl group having 9 to 15 carbon atoms, and further preferably an alkyl group having 9 to 13 carbon atoms. S is preferably a number of 3.

  Among these nitrogen-containing amphoteric surfactants, the compounds represented by the general formulas (9), (10) and (11) are preferable, the general formulas (10) and (11) are more preferable, and the general formula (10) ) Is most preferred.

  The amount of the nitrogen-containing amphoteric surfactant is not particularly limited.However, if the amount of the nitrogen-containing amphoteric surfactant is too small, the effect of improving the antibacterial property may not be obtained.If the amount is too large, the effect of increasing the amount of the compounded amount is obtained. Therefore, the amount of the nitrogen-containing amphoteric surfactant is preferably 0.5 to 500 parts by mass, more preferably 1 to 200 parts by mass, and more preferably 2 to 100 parts by mass with respect to 100 parts by mass of the component (A). Even more preferred is 10 to 75 parts by weight.

  In the present invention, the plant-derived extract is a plant, algae, or fungi, or a specific site such as a flower, a leaf, a stem, a fruit, a bark, a root, a seed, a resin, or squeezed, dried, crushed, or fermented. And the like, and then obtained by extraction with a solvent at normal temperature or under heating, and soluble in water, ethanol, propylene glycol or fats and oils. Alternatively, the extract may be diluted, concentrated, or dried. Further, the essential oil may be obtained by using a steam distillation method, an extraction method, a chromatography method or the like.

  Examples of the extraction solvent include those commonly used for extracting natural product components, for example, water; alcohols such as methanol, ethanol, propanol, and butanol; polyhydric alcohols such as ethylene glycol, propylene glycol, butylene glycol, and glycerin; acetone, methyl ethyl ketone Ketones such as methyl acetate and ethyl acetate; ethers such as tetrahydrofuran, diethyl ether and polyethylene glycol; halogenated hydrocarbons such as dichloroethane and chloroform; aliphatics such as petroleum ether, n-hexane and cyclohexane. Hydrocarbons; aromatic hydrocarbons such as toluene; pyridines; sodium chloride solution and the like, with water, ethanol, propylene glycol and butylene glycol being particularly preferred.

  Examples of a plant that can be used as a plant-derived extract include, for example, arch chalk, almond, eye, Aisenhardtsia polystachya, eye bright, Aono agave vulgaris, Aomogi, Acacia konsina, Acacia Senegal, Acacia senegal gum, Acacia declense, Acamethaxa, Akaharnile, Acadia japonica, Agui, Agrimonia eupatoria, Akebi, Asagao karakusa, Thistle, Ashi, Ashitaba, Ajugatsurkestana, Azuki, Asunaro, Asparagus, Asparasaslinearis, Acerola, Asenyaku, Asenyaku noki, Atlas Asada Gace Reiocalpus, Avena Strigosa, Avocado, Ama, Amacha, Amachaul, Amadokoro, Eelgrass, Amyris Balsamifera, U.S.A. American ginger, american ginseng, american carrot, amomum aromachikum, arakashi, arcana, arctium majus, arctium minus, arnica, arnica camonis, alpinia officinalum, alfalfa (also known as purple coconut palm), aloe vera, anzange, apricot , Angelica, Antiris bruneraria, Amperopsis grossentata, Ammarok, Epimedium, Izayoibara, Itadori, Italian cypress, Strawberry, Fig, Ichiyakusou, Ginkgo biloba, Itran, Carob, Ibukitrano, Imosemil, Nettle, Iranica , Iris parida, iwabenkei, iwamitsuba, haricot bean, fennel, witania somnifera, turmeric, umebasaishin, utsbogusa, udo, umumi memo Ki, Ume, Yuyak, Uralkanzou, Uri, Urbaraktuka, Ulmus davidiana, Unkariatmentosa, Unshumikan, Agets, Eilanthai, Edelweiss, Eleuthero, Ezoheviichigo, Ezomisohagi, Echinashi, Echinacea paridae, Neenidae , Elemi, Enju, Pea, Empitus juniper, Emmerweed, Oleander, Oleum, Milk Thistle, Oleander, Oozodenda, Ookara no Peas, Okis Makurata, Okis Maskra, Orchid,

Oak (also known as European oak), giant mulberry, giant bonsai, giant bonsai, giant squirrel, giant squirrel, giant milt palm, giant pokeweed, barley, allspice, okazeri, okra, shiroibana, giant squirrel, giant squirrel , Opuntia streptacantha, Opuntia tuna, Dutch mustard, Dutch peonies, olives, Origanum heracleochikum, Ortosihon stamineus, Olmenis mulchikauris, orange, Orobankerapum, Gardenia tahitensis, carnation, Kayasenegalensis , Cacao, kyoku, cassia, cashew nut, cascara sagrada, cassia italica, kappaficus alvarez, cattle , Canadian Hydrastis, Canary Tree, Kaninabara, Kanokosou, Kabaanatake, Turnip, Gama (Kama), Chamomile (Also known as Chamomile), Kamimebuki, Kajupte, Karakshakeman, Orasugi, Karaukiki, Garana, Galikabara, Cauliflower, Karinka ), Garcinia Cambodia, Carrot, Kawamurai (also known as Inchinko), Licorice, Agaricus, Rubus, Kiwi, Kikarasuuri, Kikunigana, Kigelia Africana, Kidachiaroe, Kidachihakka, Kinnoki, Quinoa, Kihada (also known as Obanaku), Kibanazuna Prickly pear, millet, gymnema, kimono crucian, cassava, cabbage, caraway, cucumber (also known as cucumber), kyoou, gyoryu, gyoryubai, ki Ya, Kiri, myrtle (also known as honeysuckle), guar, guava, quince seed, Kuueru dregs Aruba, candlenut,

Wolfberry, celandine, kudzu, camphor tree, spiderwort, gardenia, ouwaushi, kumazasa, kumazudura, kumanogiku, cumin, kurameria triandra, clara, granberry, christum maritimum, grindelier lobusta, clintonia borealis, krumabasou, walnut, Grapefruit, clematis, black garlic, black walnut, black blossom, gross, black currant, black migua, mulberry, keikei, kei (also known as cinnamon), geum urbanum, geum rebarre, cape aloe, poppy, gekkavidin, gekko, ghetto, kemiyama kozanagena genus , Gennoshoko, Kemponashi, Kouki, Koukitan, Koukaiten, Kosuigaya, Kobo, Kouhone, Coffeeno , Koganebana, Coccinia indica, Kokutan, Cochlearia officinalis, Cowberry, Coconut palm, Goshoichigo, Pepper, Koshironosendangusa, Cochineal cactus, Kossetsukokoku, Kochoran, Konara, Kohakobe, Burdock, Sesame seeds, Wolverine, Wolves Coleus Barbatus, Gorenshi, Fenugreek, Consulango, Comfrey (also known as finlock), Combretum Micrantham, Sisal Asa, Saishin, Cyperas Escrentas, Cypress, Saijo, South Rare Involclata, Saxima Button, Sakura, Sakurabakanboku, Pomegranate, sugar maple, sugar cane, sugar pine, sasanqua, sassafrasinoki, saffron, savonsou, salasouju, salix nigra, sals Li, Thang Ina rear Kanaden Corporation cis, hawthorn, pansy, Panax ginseng, Cornus, pepper, Sanpenzu,

Cyate Medularis, Cyanochis aracnoidea, Shea butter tree, Shiozakisou, Shishinburiumirio, cystrose (also known as Rabdanham), Cystus monsperiensis, Cysstudaniferus, Shiso, Shichihenge, Shinanoki, Shibagi, Zipterics odorata , Siberian fir, Simulba, Shisimifugadafurika, Spiraea, Potato, Peonies, Jasmine, Janohige, Janomeelica, Shuksha, Juzdama, Gypsophila paniculata, Junipersmexicana, Junsai, Ginger, Ginger, Kyobumon Rhubarb, white birch, silane, white pepper, white canopy, white canopy, white cane, white cane, cinchona kalisaya, synsepalm durshificum, cymbidium, shi Procos racemosa, sweet acacia, watermelon, honeysuckle, scabiosa albensis, horsetail, scutellaria galericulata, stevia, strobe pine, spiny bamboo, spirulina platensis, spirulina maxima, svelicheuil, spelled wheat, sminomizakura, smilillax aristolochia eholia , Scots pine, Scots pine, Scots pine, Scots pine, St. John's wort, St. John's wort, St. John's wort, St. John's wort, St. John's wort, Wed. Willow, willow dandelion, horse chestnut, horse chestnut, horse chestnut Rico, pear, meadowsweet,

Sorbus aucuparia, Ceylon Nikkei, Aedes aegypti, A. aureus, A. aureus, A. americana, A. hazel, A. a. Butushiholia, Sequoia male, Cecil oak, Sedum purpurium, Zeniaoi, Senega, Geranium, Celsidium florida, B. cereus grandiflorus, Celery, Senkyu, Centifolia rose, Centipeda cunningamy, Senninkoku, Sempokuka, Senburi, Soujutsu, Saw Palmetto, Sokei, Buckwheat, Solanumurico Calpum, Daikyo, Japanese radish, Daisanchiku, Soybean, Daidai, Ituriogi, Thyme, Thai cypress, Takasaburo, Tachijakoso, Tachibana, Tabunoki, Tavebuia aberanedae, Tamasakitsurafuji, Damask rose, Onion, Damiana, Taragon, Tanzine, Tamborissa trichophylla, Chigaya, Cha (tea), Chubotokeiso , Clove, Datura, Sturgeon, Chilea mentosa, Tucumea firconi, Camellia, Tsurugumi, Tsurukudami, Tsurureishi, Tea tree, Dioscorea compositor, Dioscorea vilosa, Dioscorea mexicana, Teuchigurumi, Tekoma clearis Duke, Dubois Rajcardochi, Terminaria, Tencha, German iris, German spruce, spruce, capsicum, touuki, calendula, tou Zumimochi, spruce, corn, Tourousou, horsetail, Houttuynia, hemlock, Toshishi (aka Mamedaoshi), juniper, tomato, bird Gosnay La Foe Num, Torumenchira,

Troroa antelope, Nagabagi-sugi, Nagikada, Eggplant, Nazuna, Sword bean, Feverfew, Natsubodaiju, Jujube, Date palm, Nankyoso, Nambanai, Nambanksafuji, Nioisumire, Niotei Kuani, Niiyogani, Niiyogani, Niiyonigani Carrots, garlic, ninfaea alba, pear blossoms, noibara, nosenhallen, nojisumire, nobara, noborogiku, pineapple, hibiscus, pine, baobab, bakuhousia citriola dorado, bacmondou, bacopa monniera, jago romica, hascho, pacarica Sugenisteroides, Passiflora Arata, Adlay, Banana, Hanamint, Honeysuckle, Vanilla, Vanilla Tahi Cissis, hane senna, papaya, paphiopedilum maudiae, haberraria rhodopensis, hamanas, hamamelis, chayatouri, rose, parie aria, harienju, harpagophytum, palmarosa, barosma betulina, bangkom, pansy, bambara mame, beet, hollyhedgehina , Bitter almond, bitter orange, hydrastis canadensis, daisies, corn poppy, binankazura, pinus heda, hinoki, cypress, cypress, daisy daisy, hippophaeramnoides, sunflower, himekoji, himekora, himetsurunichinicoubari, beetle Chickpeas, lentils, fin beetles, below mallow, pilocarpus pennati holius, loquat, betel wax, fa Iapanicrata, balsam chadula, pueraria mirifica, ferrugalvaniflua, coltsfoot, boukulyo, fusazakisuisen, fusascuri, fusafujitsugi, fussanus spicatus, petitgren, petitkopetalum oracoides, bustrogeum, bucharum , Futomomo, Beech, Fuyuzanshaw, Fuyubodaiju, Fragaria tyroensis, Brazil nut tree, French cauldron, French lavender, Planta goafura, Planta obata,

Plantagopsylium, primulassimensis, prunes, prunus africana, prunus cellotina, plumeria, plectrants barbatas, brechia hyacintina, bay, hayflower, hazelnut, pecan, vetiver, loofah, penny royal mint, safflower, safflower , Safflower assembly, pepo pumpkin, pterosaur, pelargonium capitatum, helichism arenalium, helichism angstifholium, helichism italikum, bergamot, peltholm da silachis, peru balsam, bergamot, berberis aquiholium, veronica ophasi Naris, Henna, Henruda, Butterfly, Bawshukuboku, Bouchunka, Baldwink, Spinach, Spinach, Hawkweed, Honoki, Hokubeif Rosou, Bokoa proua sensis, Boswellia serrata, Hosoba senna, Hosova valengic, Bodaiju, Button, Hop, Poterium officinale, Jojoba, Polygonatum mulchiflorum, Bold, Poncan, Macadamia, Magnolia officinalis, Magnolia bionzi, Magwa jag , Masaki, Madake, Pine, Matsurika, Matecha, Madonna Lily, Majorana, Maria Thistle, Malpighia Gravure, Quince, Malonie, Mango, Mangosteen, Manshuka Akamatsu, Manjugiku, Mandarin Orange, Mandrake, Mishimasaiko, Mizuhakka, Mizuremon , Mitsugashiwa, mitra car pass skaber, mimosatenuiflora, mircilia duvia, myrrh (aka mousyakuju), mirotamnus flavelli Oria, Mirobaran, soapberry, purple, Murasaki Shikibu, purple assembly, Echinacea purpurea, Murayakoenji, basil, evening primrose, Melia bruises Zillah Kuta,

Melissa (also known as Kosuihakka), melilot, merosuria, melon, menta albensis, moco mugwort, mourera fulbiathiris, magnolia, moscartabara, mosveen, motsuyaku, momo, momotamana, yakumosa, cornflower, yashabana, yachiyana, yachiyana, yachiyanagaya Yamazakura, yamanoimo, yamamogi, yuugao, eucalyptus, eupatorium ayapana, eupatorium rebaudianum Bertoni, yukinoshita, yuzu, yusoboku, yucha, yukkagrauka, yuccashijigera, lily, yoshitsurukinbai, yoshihoshizuki Pokeweed, european goldenrod, european strawberry, european greek, european black oak, european birch, european beech, europe Stonecrop, European fir, mugwort, artemisia, lychee (also known as reishi), lime bean, lime, rye, lilac, radiata pine, rattania, peanut, ranunculus ficaria, lavandula hybrida, rafuma, lavender, larix europaea, larareadi Balikata, Larea Mexicana, Rambutan, Lithosamnium Carcolum, Lithosaglutinosa, Longan, Liriosmaobataki, Apple, Rooibos, Lupinus Bucarnos, Lubusvilos, Lumpuyan, Luridisa, Lullien Sou, Respedesa, Resedal Temara, Lettuce , Ledum pulse tray, Lebanon cedar, Leviscium officinale, lemon, lemongrass, astragalus, rosewood, rosemary, lowbush blueberry, Makamitsure, Laurel (also known as laurel), log wood, Robusta coffee trees, wild time, wasabi, horseradish, moringa oleifera, Watasugigiku, Watafujiutsugi, badass terrier Indica, such as Burnet plants;

  Ascofilm Nodsum, Aname, Ouukimo, Okinawamozuku, Gigartina Serrata, Kugelmaniella Girata, Sargassum Filippendura, Sargassum Fushiform, Sargassum Muticam, Sphacelaria Scopalia, Durvillea Antartica, Padina Pabonica Himantaria elongata, Fucus serratus, Pervetian canariclata, Macrocystis spiferifera, Mitsui kelp, Laminaria ochlorosquid, Laminaria croostoni, Laminaria diguita, Laminaria hyperborea, Wakame, Asparagopsis almata, Igis, Kagibaranori , Swordfish, geridium kurtiraginium, simi, swordfish, dars, chinorimo, tochaka, porphyridium cruentum, malbatis macronori Lithosamnium corallioides, Anaoasa, Chlorella emersoni, Chlorella pyrenoidosa, Dunaliella salina, Dunaliella bardawill, Hiraa nori, Spirulina platensis, Spirulina maxima, Haslea australia, Deleresia sanguinea, Picaeuro baculopus lupus Algae such as les, Haematococcus pluvialis, cyanobacteria, condor crisps, coral peach, sea whip, and red algae;

  Examples include lichens and mycelia such as Ebernia furfurasea, Tsunomatagotake, Usnia barbata, Oshagujitake, Kabaanatake, Shiitake, Ningyotake, Himematsutake, Fumusinatsutaketake, Kabaanatake, Choreimaitake, and Cordyceps.

  The amount of the plant-derived extract is not particularly limited, but if the amount of the plant-derived extract is too small, the effect of improving antibacterial properties may not be obtained.If the amount is too large, the effect of increasing the amount of the plant-derived extract may not be obtained. The amount of the extract is preferably from 0.1 to 1,000 parts by mass, more preferably from 0.5 to 200 parts by mass, most preferably from 1 to 100 parts by mass, per 100 parts by mass of the component (A).

  Examples of the zinc compound include zinc acetate, zinc laurate, zinc myristate, zinc palmitate, zinc ricinoleate, zinc undecylenate, zinc aspartate, zinc acetylmethionine, zinc gluconate, zinc citrate, and polypyrrolidone carboxylic acid. Organic acid zinc salts such as zinc and zinc picolinate; zinc sulfonates such as zinc p-phenolsulfonate; zinc phosphate salts such as zinc ascorbyl phosphate, zinc sodium cetyl phosphate and DNA zinc; zinc complexes such as zinc pyrithione Zinc supporting zeolite such as (silver / zinc / ammonium) zeolite and silicic acid (ammonium / silver / zinc / aluminum); aluminum hydroxide such as aluminum oxide / zinc, aluminum oxide / zinc / cerium, aluminum oxide / zinc / iron Calcined products such as sulfite Inorganic zinc salts such as zinc sulfide, zinc chloride, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, potassium zinc sulfate, zinc iodide, basic zinc carbonate; (hydroxide / carbonate) (Mg / Al / Zinc), zinc oxide and the like. Among these, a compound which easily dissolves in water to become a zinc ion is preferable, the solubility in 100 g of water at 20 ° C. is preferably 5 g or more, and more preferably 10 g or more. Examples of such zinc compounds include zinc sulfate, zinc chloride, zinc gluconate, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, zinc potassium sulfate, zinc iodide, and the like.

  The amount of the zinc compound is not particularly limited, but if the amount of the zinc compound is too small, the effect of improving the antibacterial property may not be obtained.If the amount of the zinc compound is too large, the effect of increasing the amount of the zinc compound cannot be obtained. The amount is preferably from 0.02 to 10 parts by mass, more preferably from 0.05 to 5 parts by mass, most preferably from 0.1 to 2 parts by mass, per 100 parts by mass of the component (A).

  Among these, the antibacterial effect is particularly enhanced by the synergistic effect of the component (A) and the component (B). Therefore, the antibacterial composition of the present invention contains, as the component (C), a chelating agent and a low-molecular polyol (however, (A) excluding diol compounds corresponding to component), and one or more compounds selected from the group consisting of nitrogen-containing nonionic surfactants; and a chelating agent and a nitrogen-containing nonionic surfactant. More preferably, it contains one or more compounds selected from the group consisting of

  The antibacterial composition of the present invention can exhibit a high antibacterial effect not only in a uniform aqueous solution but also in an emulsified system, and in the case of an emulsified system, may be an O / W emulsion or a W / O emulsion, or may be an O / W / O emulsion, It may be a W / O / W emulsion or these types. Further, the antibacterial composition of the present invention has a high antibacterial effect not only on bacteria but also on fungi such as molds.

  The use of the antibacterial composition of the present invention is not particularly limited, and may be used in the same manner as known antibacterial agents, bactericides, disinfectants, and fungicides for the purpose of antibacterial, disinfecting, disinfecting, and fungicide. it can. For example, a commonly used method such as a method of spraying an object to be subjected to an antibacterial treatment, a method of applying the object, a method of impregnating the object, and a method of immersing the object can be used as it is. In addition, as an application, the antibacterial composition of the present invention may be used as a medical cleaning agent for disinfecting and cleaning medical instruments and affected parts, a household cleaning agent for disinfecting and cleaning tableware, a cleaning agent for the food industry, and container transport. Conveyor lubricant, food packaging film, fiber, synthetic resin, wood, antibacterial agent for antibacterial processing of daily necessities, body wash, cosmetics, fabric softener, water or non-aqueous paint, non-woven fabric, etc. When used as a wet tissue, toilet seat cleaner, or antibacterial agent for fibers, any fibers such as cotton, polyester, acrylic, and nylon may be treated by a general method such as stirring, dipping, or spraying. Further, the antibacterial composition of the present invention can be applied or sprayed on the surface of wood, daily necessities and the like. Further, when using a synthetic resin or the like, the antibacterial composition of the present invention may be applied to the surface by coating or spraying after molding, or kneaded at the time of molding to maintain the antibacterial effect. You can also. Among these, the antimicrobial composition of the present invention is highly safe for the human body, and therefore, it is preferable to use the antibacterial composition for cosmetics and body cleansing agents that directly touch the human body. More preferably, it is used for an agent.

  Examples of cosmetics that can preferably use the antibacterial composition of the present invention include, for example, cosmetics, for example, shampoo, dry shampoo, rinse integrated shampoo, hair rinse, hair conditioner, hair pack, hair treatment, hair tonic, pomade , Tic, hair cream, hair wax, hair gel, hair foam, hair mousse, hair mist, hair lotion, permanent wave agent, hair dye, etc .; hair care cosmetics; facial cleanser, facial cleanser, facial cleanser, cleansing cream, cleansing foam, hand Soap, body soap, body lotion, sunscreen, lotion, milky lotion, serum, face cream, cold cream, face pack, antiperspirant, shaving soap, shaving foam, shaving foam Skin care cosmetics such as lip balm, shaving lotion, after shave lotion, after sun lotion; makeup cosmetics such as foundation, concealer, face powder, blush, mascara, eyeliner, eye shadow; lip balm, bath salt, etc. Can be

  The cosmetic containing the antibacterial composition of the present invention may contain a surfactant usually used in cosmetics. Examples of such a surfactant include an anionic surfactant, a cationic surfactant, a nitrogen-free nonionic surfactant, and the like.

  Examples of the anionic surfactant include higher fatty acid salts, higher alcohol sulfates, sulfated olefin salts, higher alkyl sulfonates, α-olefin sulfonates, sulfated fatty acid salts, sulfonated fatty acid salts, and phosphoric acid. Ester salt, fatty acid ester sulfate, glyceride sulfate, fatty acid ester sulfonate, α-sulfofatty acid methyl ester, polyoxyalkylene alkyl ether sulfate, polyoxyalkylene alkyl phenyl ether sulfate, poly Oxyalkylene alkyl ether carboxylates, acylated peptides, fatty acid alkanolamides or their alkylene oxide adducts, sulfates, sulfosuccinates, alkylbenzene sulfonates, alkylnaphthalenes Sulfonate, alkylbenzimidazole sulfonate, polyoxyalkylene sulfosuccinate, N-acyl-N-methyltaurine salt, N-acylglutamic acid or a salt thereof, acyloxyethanesulfonate, alkoxyethanesulfonate, N -Acyl-β-alanine or a salt thereof, N-acyl-N-carboxyethyltaurine or a salt thereof, N-acyl-N-carboxymethylglycine or a salt thereof, acyl lactate, N-acyl sarcosine salt, and alkyl or alkenyl Amino carboxymethyl sulfate and the like. Examples of the counter ion of such an anionic surfactant salt include alkali metal ions such as lithium, sodium and potassium; alkaline earth metal ions such as calcium and magnesium; ammonium; monoethanolammonium, diethanolammonium, and triethanolammonium. And organic ammonium such as monoisopropanol ammonium, diisopropanol ammonium and triisopropanol ammonium.

  Examples of the cationic surfactant include amine surfactants such as alkyldimethylamine, alkenyldimethylamine, fatty acid dimethylaminopropylamide, and fatty acid diethylaminoethylamide; alkyltrimethylammonium salt, alkenyltrimethylammonium salt, alkyldiethanolammonium salt Alkenyl diethanol ammonium salt, alkyl dimethyl benzyl ammonium salt, alkenyl dimethyl benzyl ammonium salt, dialkyl dimethyl ammonium salt, alkyl diethanol ammonium salt, alkyl pyridinium salt, 3-alkoxy-2-hydroxypropyl trimethyl ammonium salt, polyoxypropylene methyl diethyl ammonium And ammonium salt-based surfactants such as salts. Examples of the counter ion of the ammonium salt-based surfactant include a chloride ion and a bromine ion.

  Examples of the nonionic surfactant containing no nitrogen include polyoxyalkylene alkyl ethers, polyoxyalkylene alkenyl ethers, and polyoxyethylene polyoxypropylene alkyl ethers (addition forms of ethylene oxide and propylene oxide are random and block-like. Any), polyethylene glycol propylene oxide adduct, polypropylene glycol ethylene oxide adduct, glycerin fatty acid ester or its ethylene oxide adduct, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyl polyglucoside, sucrose fatty acid ester, alkyl (Poly) glycerin ether, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, fatty acid methyl ester Ether ethoxylates, and the like.

  Cosmetics and cleaning agents containing the antibacterial composition of the present invention, other than the above-described surfactant components, other components within a range that does not impair the purpose of the present invention, for example, silicone oil, thickener, oil agent, Powders (pigments, dyes, resins), other antibacterial agents, fragrances, humectants, physiologically active ingredients, salts, solvents, antioxidants, chelating agents, pearling agents, neutralizing agents, pH adjusters, enzymes, etc. Components can be appropriately blended.

  Examples of the thickener include dimethyldiallylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer, cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, and agar , Gelatin, tamarind seed polysaccharides, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabinogalactan, karaya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, β-glucan, gellan gum And dextran.

  Oils include volatile and non-volatile hydrocarbons, higher alcohols, medium- to high-chain fatty acids and their esters, oils and fats, which are usually used in cosmetics, and may be liquids, pastes, or solids at room temperature. However, a liquid excellent in handling is preferable. Examples of oils include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol, octyl dodecanol, fatty acids such as isostearic acid, undecylenic acid, and oleic acid, myristyl myristate, hexyl laurate, and oleic acid. Esters such as decyl, isopropyl myristate, hexyldecyl dimethyloctanoate, glyceryl monostearate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, hydrocarbons such as liquid paraffin, petrolatum, squalane, lanolin, and reduction Examples include waxes such as lanolin and carnauba wax, oils such as mink oil, cacao butter, coconut oil, palm kernel oil, camellia oil, sesame oil, castor oil, and olive oil.

  Examples of the powder include dyes such as Red No. 201, Yellow No. 4, Blue No. 1, Black No. 401, lake dyes such as Yellow No. 4 Al Lake, Yellow No. 203 Ba Lake, nylon powder, silk powder, and silicone powder. , Cellulose powder, silicone elastomer spherical powder, polymers such as polyethylene powder, colored pigments such as yellow iron oxide, red iron oxide, chromium oxide, carbon black, ultramarine blue, navy blue, etc., white pigments such as zinc oxide and titanium oxide, talc Mineral pigments such as barium sulfate, calcium carbonate, magnesium carbonate and magnesium silicate, inorganic powders such as silica and alumina, bentonite, smectite, boron nitride And the like. The shape of these powders (spherical, rod-like, needle-like, plate-like, irregular, flake-like, spindle-like, etc.) is not particularly limited.

  These powders may be subjected to conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, poly Surface treatment may be performed in advance by acrylic acid treatment, metal soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, or the like.

  Other antibacterial agents include, for example, paraben antibacterial agents such as methylparaben and ethylparaben; imidazole antibacterial agents such as thiabendazole, methyl 2-benzimidazolylcarbamate and imidazolidinylurea; trichlorocarbanilide, cloflucarban and the like. Carbanilide antibacterial agents; thiazole antibacterial agents such as benzothiazole; triazine antibacterial agents such as debuconazole and cabinone; biguanide antibacterial agents such as chlorhexidine hydrochloride and polyhexamethylene biguanide, etc., and these antibacterial agents are used in combination. Should be used carefully in consideration of irritation to the human body.

  Examples of the humectant include diethylene glycol monoethyl ether, deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, chondroitin sulfate, collagen, elastin, chitin, chitosan, biomolecules such as hydrolyzed eggshell membranes, amino acids, sodium lactate, Urea, sodium pyrrolidonecarboxylate, betaine, whey and the like can be mentioned.

  Examples of the solvent include purified water, ethanol, light liquid isoparaffin, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, next-generation chlorofluorocarbon, and the like.

  Hereinafter, the present invention will be described specifically with reference to Examples. In the following examples, “%” and “ppm” are on a mass basis unless otherwise specified.

<Compounds used in the experiment>
(A) Component A1: 1,2-pentanediol A2: 1,2-hexanediol A3: 1,2-octanediol A4: 1,2-decanediol (B) Component B: benzyloxyethanol

(C) Component C1: Glutamic acid diacetate 4Na
C2: Glycerin C3: Coconut fatty acid monoethanolamide (Cocamide MEA)
(D) Component D1: Phenoxyethanol D2: Methylparaben D3: Glyceryl caprylate

  Using the above-mentioned compounds, antibacterial agents of Examples 1 to 10 and Comparative Examples 1 to 18 shown in Table 2 were prepared. The numbers in Tables 1 and 2 are% by mass.

<Bacteria used in the experiment>
B.cep: Burkholderia cepacia (bacterium)
P.aer: Pseudomonas aeruginosa (bacteria)
A.bra: Aspergillus brasiliensis (fungus)

  Formulations 1 and 2 were prepared with the following formulations. There are two types of the antimicrobial agents, 0.4% by mass and 0.8% by mass. In the test for B. cep and P. aer, those having a compounding amount of 0.4% by mass have a compounding amount of 0%. 0.8% by weight was used in the test against A.bra. Note that Formula 1 is a skin cream formula, Formula 2 is a conditioner formula, and the emulsifying system is an O / W emulsion.

<Prescription 1: Skin cream>
20% by weight of triethylhexanoin
Sorbeth-30 oleate-30% by mass
Cetearyl alcohol 0.2% by mass
Glycerin 0.2% by mass
(Acrylates / alkyl acrylate (C10-30)) cross polymer 0.1% by mass
0.4% by mass or 0.8% by mass of antibacterial agent
Suitable amount of sodium hydroxide (adjusted to pH 6.0)
Water

<Prescription 2: Hair conditioner>
Stearyl alcohol 1.0% by mass
Behentrimonium chloride 0.5% by mass
0.5% by mass of cetanol
Amodimethicone 0.5% by mass
0.4% by mass or 0.8% by mass of antibacterial agent
Water

In a sterilized 30 mL glass bottle with a lid, 20 mL of the formulation of Formula 1 or Formulation 2 and 0.2 mL of a bacterial solution having a bacterial concentration of 1.0 × 10 ⁸ cfu / mL are added and uniformly mixed. The glass bottle was stored in a thermostat at 25 ° C., and B.cep and P.aer were sampled after 2 and 7 days, A.bra was sampled after 7 and 28 days, and the concentration of viable cells (unit: cfu) / ML), and the antibacterial activity value was determined by the following formula. A higher antibacterial activity value indicates a higher antibacterial property. Tables 3 and 4 show the results using Formula 1, and Tables 5 and 6 show the results using Formula 2.
Antibacterial activity value = 6-Log (concentration of viable cell count (cfu / mL))

  When A1, A2, A4, and B1 were used alone, Formulations 1 and 2 showed little antibacterial activity. When A3 was used alone, antibacterial activity against bacteria (B.cep, P.aer) was observed, but no antibacterial activity against fungi (A.bra) was observed. Each of the antibacterial compositions of the present invention, which uses the component (A) and the component (B) in combination, exhibits high antibacterial properties not only against bacteria but also against fungi, and has a synergistic effect on the components (A) and (B). It turns out that there is. The addition of the component (C) further improved antibacterial properties.

Claims (6)

An antibacterial composition containing a diol compound represented by the following general formula (1) as the component (A) and benzyloxyethanol as the component (B).

(In the formula, R ¹ represents an alkyl group having 3 to 8 carbon atoms.)   The antibacterial composition according to claim 1, wherein the mass ratio of the component (A) to the component (B) is from 10:90 to 90:10.   Further, as the component (C), a chelating agent, a low molecular polyol (excluding the diol compound corresponding to the component (A)), a nitrogen-containing nonionic surfactant, a nitrogen-containing amphoteric surfactant, a plant-derived extract and a zinc compound The antibacterial composition according to claim 1, comprising one or more components selected from the group consisting of:   The antibacterial composition according to any one of claims 1 to 3, which is used for preserving cosmetics.   A cosmetic comprising the antibacterial composition according to any one of claims 1 to 4. A method for imparting antibacterial properties to a cosmetic, comprising adding a diol compound represented by the following general formula (1) (component (A)) and benzyloxyethanol (component (B)) to the cosmetic.

(In the formula, R ¹ represents an alkyl group having 3 to 8 carbon atoms.)