JP2006052146A - Beautifully whitening agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To find out further effectiveness in utilizing levan as a blending component for a cosmetic. <P>SOLUTION: This levan has an excellent beautifully whitening effect, more in detail, a melanin production inhibitory effect, tyrosinase activity inhibitory effect or pigmentation inhibitory effect, and by using the levan, it is possible to constitute a beautifully whitening agent. Further, by blending the beautifully whitening agent for using as a cosmetic or an externally used medicine, the effective prevention or improvement of various skin disorders (e.g. blackening of a skin such as spots, freckles, sun burn etc., and the generation of dullness, etc.) can be expected. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a whitening agent, and in particular, to a whitening agent having a melanin production inhibitory action, a tyrosinase activity inhibitory action, or a pigmentation inhibitory action.

  To date, one of the ingredients known as a cosmetic ingredient is levan. As for the knowledge about levan, in addition to being widely used as a natural film-forming polymer and water-soluble polymer, levan having a polymerization degree of 8-30 has a bifidobacteria growth promoting action (Patent Document 1) and a cholesterol absorption inhibiting action. , Blood pressure suppressing action, intestinal regulating action, immune enhancing action, antitumor, antiallergic and cell membrane permeability promoting action (Patent Documents 2 and 3), preventing and treating colon cancer for non-bovine mammals (Patent Document 4), Anti-anemic action of levan oligosaccharide (Patent Document 5), anti-lipemic and anti-obesity action of Levan and its partial degradation products (Patent Document 6), cell protection action from ultraviolet rays, cell proliferation action, moisturizing action, alleviating skin irritation Various effects such as an action and an action for improving skin elasticity (Patent Document 7) are disclosed. Furthermore, hair growth promoting action (Patent Document 8) and antiviral action (Patent Document 9) of sulfated levan, bile acid adsorption action of levansterol derivative (Patent Document 10), moisturizing action and skin protection of phosphatidyl group-introduced levan Applications of levan derivatives such as action (patent document 11), stimulus-suppressing action of hydrophobic group-substituted levan derivatives (patent document 12) and application to bath agents, fragrances, etc. (patent documents 13 and 14) are disclosed. . Thus, Levan is an excellent material having basic properties as a cosmetic base and having various effectiveness. However, because there are many other cosmetic ingredients that currently have a variety of efficacy, the effectiveness as a cosmetic ingredient that has been disclosed so far with respect to Levan is significantly superior to other ingredients. Is not expensive.

JP-A-57-18982 Japanese Unexamined Patent Publication No. 03-198773 Japanese Unexamined Patent Publication No. 03-219889 Japanese Patent Laid-Open No. 2001-526671 Japanese Patent Laid-Open No. 11-302182 JP 05-339159 A JP 2003-277225 A JP 09-188607 A JP 2002-293803 JP Japanese Patent Laid-Open No. 10-330422 JP-A-10-226616 Japanese Patent Laid-Open No. 2001-64185 JP 2001-64157 A JP 2001-64668 A

  Therefore, in using Levan as a cosmetic ingredient, the purpose is to increase the superiority of other cosmetic ingredients, and in addition to various actions disclosed so far, The challenge is to find further effectiveness of Leban.

  The present inventors have found that levan has an excellent whitening action, in particular, a melanin production inhibitory action, a tyrosinase activity inhibitory action or a pigmentation inhibitory action, and can be used as a whitening agent in constituting cosmetics. I found something.

  That is, the present invention provides a whitening agent containing levan having an excellent whitening effect.

  Levan used in the present invention has an excellent whitening action, specifically, a melanin production inhibitory action, a tyrosinase activity inhibitory action or a pigmentation inhibitory action, and it is possible to constitute a whitening agent by using Levan. . In addition, when this whitening agent is used in cosmetics or topical medicines, various skin disorders caused by excessive melanin production or accumulation (such as skin darkening, freckles, sunburn, etc., or dullness) Etc.) can be effectively prevented or improved.

  Levan used in the present invention is a linear fructose homopolymer composed of a β-2,6 glucoside bond of D-fructose, or a β-2,6 glucoside bond of D-fructose and β-2, A branched fructose homopolymer composed of one glucoside bond, specifically a compound represented by the following formula (1).

［式(1)におけるフルクトース残基中のR¹は、1残基単位で互いに独立して水素原子又は下記の式(2)で示される糖鎖から任意に選択される。式(1)中のKは5〜100000の整数を示す。］

[R ¹ in the fructose residue in the formula (1) is arbitrarily selected from a hydrogen atom or a sugar chain represented by the following formula (2) independently of each other in units of one residue. K in the formula (1) represents an integer of 5 to 100,000. ]

［式(2)におけるフルクトース残基中のR²は、1残基単位で互いに独立して水素原子又は下記の式(3)で示される糖鎖から任意に選択される。式(2)中のLは0〜500の整数を示す。］

[R ² in the fructose residue in the formula (2) is arbitrarily selected from a hydrogen atom or a sugar chain represented by the following formula (3) independently of each other in units of one residue. L in the formula (2) represents an integer of 0 to 500. ]

［式(3)におけるフルクトース残基中のR³は、1残基単位で互いに独立して水素原子又は下記の式(4)で示される糖鎖から任意に選択される。式(3)中のMは0〜10000の整数を示す。］

[R ³ in the fructose residue in the formula (3) is arbitrarily selected from a hydrogen atom or a sugar chain represented by the following formula (4) independently of each other in units of one residue. M in the formula (3) represents an integer of 0 to 10,000. ]

［式(4)中のNは0〜500の整数を示す。］

[N in Formula (4) represents an integer of 0 to 500. ]

  As the levane used in the present invention, a pharmacologically acceptable salt can also be used in the present invention, and examples of the salt include complex salts with inorganic bases and complex salts with organic bases. Specific examples of complex salts with inorganic bases include sodium salts, potassium salts, calcium salts, magnesium salts, barium salts, lithium salts, aluminum salts, copper salts, zinc salts, and iron salts. Examples of complex salts with organic bases include ammonium salt, trimethylamine salt, triethylamine salt, pyridine salt, picoline salt, ethanolamine salt, diethanolamine salt, triethanolamine salt, dichlorohexylamine salt, and dibenzylethylenediamine salt. In addition, levan used in the present invention includes any of anhydrides and hydrates thereof within the scope of the present invention.

  The levan used in the present invention can be produced by a known chemical synthesis method, a fermentation production method using microorganisms, or an extraction method from a plant. Preferably, levan having a low molecular weight (K in the formula (1) is in the range of about 5 to 100) includes, for example, a method of extracting and purifying from leaves, stems or roots of gramineous plants and liliaceous plants, and high molecular weight ( Levans of formula (1) with K of 100 or more are Rahnella aquatilis, Serratia levanicum, Bacillus subtilis, Bacillus subtilis saccharolyticus (Bacillus subtilis var saccharolyticus), Bacillus lebansuclase, Bacillus anthracis, Bacteroides fragilis, Streptococcus mutans, Streptococcus mutans, Streptococcus s. Lactobacillus reuteri, Gluconacetobacter diazotrophicus (Gluco nacetobacter diazotrophicus), Zymomonas mobilis, Pseudomonas syringae, Paenibacillus polymyxa, Acetobacter xylinum, Aerobacter aerobacter B Examples include fermentation production methods using microorganisms such as Mycobacterium tuberculosis, Microbacterium sp., Lactococcus lactis, and Actinomyces naeslundii. In particular, the fermentative production method using Rahnella aquatilis, Serratia levanicum or Microbacterium sp has a low yield of by-products and low by-products. preferable.

  When the levan used in the present invention is fermentatively produced using microorganisms, the medium used in the fermentative production is a carbon source, nitrogen source, inorganic salts, or any other nutrients required by the microorganism species used. Either a medium or a natural medium can be used. Specific examples of the natural medium include a culture medium composed of squeezed liquids such as potatoes, tomatoes, malts and other cereals and fruits, or squeezed liquids appropriately filtered. Synthetic medium contains carbon source, nitrogen source, inorganic salts, etc., as well as peptone, meat extract, corn steep liquor, casein hydrolyzate, soybean meal hydrolysate, various fermented cells and their digests, etc. It is also possible to add ingredients derived from natural products. The concentration of each component in the medium can be appropriately set to a concentration at which the levan yield is highest depending on the microorganism species to be used, the culture conditions, and the like, and is not particularly limited.

  Examples of the carbon source in the medium used for the fermentation production of levan include sucrose, glucose, galactose, mannose, maltose, lactose, sugar, starch, and molasses. In particular, sucrose or glucose is preferable from the viewpoint of easy availability and levan yield. As the nitrogen source, ammonium sulfate, ammonium phosphate, ammonium hydrochloride, urea, uric acid, glutamic acid or a salt thereof, aspartic acid or a salt thereof, glutamine, asparagine, alanine, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, Examples include lysine, glycine, alanine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, hydroxylysine, arginine, ornithine, histidine and the like. Inorganic salts include sodium chloride, sodium bicarbonate, disodium carbonate, magnesium sulfate, magnesium chloride, calcium chloride, calcium sulfate, calcium carbonate, monopotassium phosphate, dipotassium phosphate, monosodium phosphate, disodium phosphate Alkali metal salt or alkaline earth metal salt such as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon, arsenic, vanadium or chromium, etc., sulfate, phosphate Or nitrate etc. are mentioned. Depending on the microorganism species, culture conditions, and culture method, vitamins such as biotin, nicotinamide, calcium pantothenate, thiamine, riboflavin, pyridoxine hydrochloride, adenine, thymine, guanine, and cytosine may be used as other nutrients in the medium. It is also possible to add bases such as uracil, organic acids such as citric acid, tartaric acid, malic acid and glycolic acid to the medium.

  The culture conditions in the fermentation production of levan are arbitrarily adjusted within the range of 20 to 35 ° C. with respect to the culture temperature, and are not particularly limited, but in particular, the optimum temperature for the average growth of the microorganism species having the levan production ability A range of 25 to 28 ° C. is preferable. The pH is arbitrarily adjusted within the range of pH 2 to 10, and is not particularly limited, but is particularly preferably in the range of pH 4 to 8, which is the optimum pH for the average growth of the microbial species having the levan producing ability. The culture is performed under aeration conditions, and numerical values relating to the amount of oxygen in the culture solution, such as the dissolved oxygen concentration and oxygen transfer capacity coefficient, are arbitrarily set and are not particularly limited.

  The composition of the medium and the culture conditions in the fermentation production of levan need only be adjusted at the start of the culture, but in combination with the growth phase and stationary phase of the microorganism and the time when the levan production ability is high, It is also possible to change the culture conditions. By performing the operation, the produced levan can be obtained with a high yield. The culture method is arbitrarily selected from batch culture or continuous culture based on the scale of equipment used for the fermentation production of levan, the desired yield of levan, or the time required for production.

  As a method of inoculating the microorganism medium in the fermentation production of levan, pre-culture with a medium having the same composition as the medium used for the fermentation production or a medium suitable for the growth of the microorganism to be used, and the microorganism to be used is grown or trained appropriately. Thereafter, a method of adding an appropriate amount of the collected cells to the fermenter, or a method of directly adding a certain amount of cells stored in a freeze-dried state or a frozen storage state in advance. Furthermore, the cells finally recovered in the fermentation production of levan can be used as they are for the next fermentation production. Furthermore, it is possible to collect the cells more easily by holding or embedding the cells in an appropriate carrier.

  As a method for recovering levan from the medium after fermentation production, the cells in the medium are removed and then recovered by a known method such as an acid precipitation method, a solvent precipitation method, or a membrane purification method. Examples of the method for removing the cells from the medium include filtration performed by appropriately combining a filter aid, filter paper, glass filter, membrane filter having a diameter of 0.2 to 0.65 μm, and the like. The method for recovering levan from the medium after removing the cells is arbitrarily selected from known methods such as the acid precipitation method, the solvent precipitation method, and the membrane purification method, but the solvent precipitation method is particularly preferred because of its ease of operation. The organic solvent used in the solvent precipitation method is not particularly limited as long as it has a low solubility of levan, but specifically, alcohols such as methanol, ethanol, propanol, butanol, propylene glycol, butylene glycol, glycerin, acetone, and the like. , Acetonitrile, hexane and the like. In order to suppress the growth of residual cells in the collected levan, it is effective to heat-treat the medium before or after the removal of the cells within a range of 65 to 120 ° C. and 15 minutes to 24 hours.

  Moreover, it is possible to produce a low molecular weight levan or a levan having a more uniform molecular weight by further hydrolyzing the collected levan using acid, alkali, hydrolase, etc. The concentration and reaction conditions are appropriately adjusted depending on the required molecular weight. In addition, when producing a low molecular weight levan or a levan having a uniform molecular weight or its distribution, it is possible to easily remove levan outside the required molecular weight range by performing gel filtration or centrifugation. is there.

  In producing levan from plants, as an extraction method that is the production method, specifically, plant raw materials used for extraction are processed as necessary by cutting, crushing, pressing, homogenizing, etc. The method of extracting using a high solvent is mentioned. The solvent to be used is not particularly limited as long as it is a solvent capable of dissolving levan. For example, water is preferable in view of its solubility and ease of handling. Other extraction conditions such as extraction time, temperature, and pressure are not particularly limited except for conditions for denaturing levan, and can be appropriately set depending on the plant raw material species to be used.

  The method for recovering levan from the extract of the plant material is the same as the method for recovering levan from the medium, and the insoluble matter in the extract is filtered with a filter aid, filter paper, glass filter, φ0.2 to 0.65 μm. After removing the membrane filter or the like by appropriate filtration in combination, the membrane is recovered by a known method such as an acid precipitation method, a solvent precipitation method, or a membrane purification method. The method for recovering levan from the extract is arbitrarily selected from known methods such as the acid precipitation method, the solvent precipitation method, and the membrane purification method, but the solvent precipitation method is particularly preferred because of its ease of operation. The organic solvent used in the solvent precipitation method is not particularly limited as long as it has a low solubility of levan, but specifically, alcohols such as methanol, ethanol, propanol, butanol, propylene glycol, butylene glycol, glycerin, acetone, and the like. , Acetonitrile, hexane and the like. In order to suppress the generation of insoluble precipitates in the collected levan, it is effective to heat-treat at 65 to 120 ° C. for 15 minutes to 24 hours at any stage in the collection process.

  In addition, levan recovered from plant raw materials can be further hydrolyzed using acid, alkali, hydrolase, etc. to produce levan having a more uniform molecular weight, and its concentration and reaction conditions are required. The molecular weight is appropriately adjusted. Further, when producing levan having a uniform molecular weight or distribution thereof, levan outside the required molecular weight range can be easily removed by performing a gel filtration method, a centrifugal separation method, or the like.

  Examples of acids used for hydrolysis of levan produced and collected from microorganisms and levan collected from plants include hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. Inorganic acids or organic acids such as Examples of the alkali used for hydrolysis include sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate and the like. . Examples of the enzyme used for hydrolysis include aminopeptidase, dipeptidase, dipeptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, and aspartate endopeptidase. , Metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, pancreatin, chymopapain, ficin, collagenase, elastase and other proteolytic enzymes (proteases), amylase, takaamylase, cellulase, hemicellulase, pectinase, poly Polysaccharide-degrading enzymes such as galacturonase, dextranase, and pralanase, lysozyme derived from chicken egg white, lysozyme derived from human , Papaya lysozyme, turnip derived lysozyme, barley lysozyme, Zaimoriesu, lysozyme chloride, glucanase, glucoamylase uronic peptidase, chitinase, cell wall lysis enzymes such as Kirosanaze like.

  Levan produced and recovered from microorganisms and levan recovered from plants can be further refined to obtain a levan with low impurity content and more uniform quality. , Dialysis using activated carbon membranes, activated carbon treatment, chromatography using ion exchange resin, synthetic adsorbent, silica gel, etc., solvent fractionation using organic solvents using differences in solubility, differences in mass and sedimentation coefficient Centrifugation etc. are mentioned, and it combines suitably according to the required purity. In addition, when the concentration of levan in the solution is lowered or lower than the required concentration in the various steps described above, it is preferable to perform a concentration step. As the concentration method, solvent removal by vacuum concentration, freeze drying, etc. Are known methods.

  In constructing a whitening agent using the levan, the liquid levan can be used as it is as a whitening agent, or it can be used as a whitening agent by adjusting it to a fine powder form, a fine crystal form, or a pellet form. Is possible. Furthermore, it can be mixed with an excipient, a thickener, a gelling agent, etc. to adjust to a granular shape, a gel shape, or a viscous liquid to constitute a whitening agent.

  In the present invention, it is possible to constitute a cosmetic composition using the whitening agent. The dosage form of the cosmetic composition is arbitrary, and it is a capsule, powder, granule, solid, liquid, gel, foam, emulsion, cream, ointment, sheet, mousse, powder dispersion It forms dosage forms such as multilayers and aerosols. Specifically, skin lotion, essence, whitening lotion, milk, whitening milk, cream, whitening cream, ointment, whitening ointment, lotion, whitening lotion, oil, pack and other basic cosmetics, soap, cleansing cream, cleansing Examples include skin cleansing agents such as lotions, cleansing milks, and facial cleansers, foundations, white powders, white powders, makeup cosmetics such as lipsticks, blushers, eye shadows, and eyeliners, and bath preparations. Further, the content of the compound contained in the cosmetic composition is generally used in a concentration range of 0.0001% by mass or more in the total amount of the composition, preferably 0.01 to 50.0% by mass, Particularly preferably, 0.1 to 20% by mass is effective from the viewpoint of expression of the whitening effect expected in constituting a cosmetic composition.

  In addition to the above-mentioned compounds that are essential components, the cosmetic composition constituted using the whitening agent of the present invention further includes a pigmentation inhibitor, a tyrosinase activity inhibitor, a melanocyte melanin production inhibitor, and a humectant exemplified below. , Cell activator / metabolic activator, antioxidant, active oxygen scavenger / radical production inhibitor, fat metabolism promoter, UV protection agent / UV absorption promoter, astringent, anti-inflammatory agent / interleukin production inhibitor / Antiinflammatory agent, Antiseborrheic agent, Antibacterial agent / Antiviral agent, Blood flow promoter / Vessel stimulant, Antiandrogen agent, Structural proteolytic enzyme (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degradation Enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc.) Harmful agents, structural protein synthesis promoters, mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors, mucopolysaccharide synthesis promoters, intercellular adipogenesis promoters / intercellular lipid state improvers, keratolytic agents / Stratum corneum peeling promoter, plasminogen activator antagonist inhibitor, Maillard reaction inhibitor, testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter, hair matrix cell growth inhibitor / hair growth inhibitor, Active ingredients such as hair swelling agents / hair protecting agents, odorous substance erasing agents, and other plant-based materials, animal-based materials, microbial-based materials, and other natural materials that are preferred for use in forming cosmetic composition forms It is possible to provide an excellent cosmetic composition having various functions by arbitrarily selecting and using ingredients such as extracts and metabolites derived from raw materials, etc., or various compounds as additives. Can be provided. The content in the preparation is not particularly defined, but usually a concentration range of 0.0001 to 50% by mass is common.

(1) Pigmentation inhibitor Specifically, p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof and derivatives thereof, anthranilic acid derivatives, coumarins Derivatives, amino acid derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H- Imidazol-4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino- 3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor Derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprosthelic acid) Phosphorus phosphate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L -Ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbine Sulfate calcium salt, L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6 -o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphorus Acid ester sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate Isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid phosphate Potassium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid phosphate Acid ester monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galacto Pyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol Ester, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid -L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid- L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L -Ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid , 2-o-α-D-ma Lutotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5, 6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbine Acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cina Pate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α- Coferol-2-L-ascorbic acid phosphoric diester, ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbyl arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), tocopherol or its Salts and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate , Tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucosi DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl Glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-toco Ferryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β- Tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- ( Sulfoethylamino) -3- (α-toco Eleyl-6-Iroxy) propan-2-ol, 1- (Carboxypropylamino) -3- (α-tocopheryl-6-Iroxy) propan-2-ol hydrochloride, S- [3- (α-Toco Ferryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl} -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof And derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol Orotate), kojic acid or its derivatives (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl-5 -Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid Glucose, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate , Kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or a salt thereof and derivatives thereof, Baicalein or a salt thereof and derivatives thereof, berberine or a salt thereof and derivatives thereof, chrysin or a salt thereof and derivatives thereof, apigenin or a salt thereof and derivatives thereof, luteolin or a salt thereof and derivatives thereof, acetetine or a salt thereof and Derivatives thereof, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and derivatives thereof, quercetin or a salt thereof and derivatives thereof Quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and derivatives thereof, myricetin or a salt thereof And derivatives thereof, myricitrin or a salt thereof and derivatives thereof, dachiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or a salt thereof and derivatives thereof, pinocembrin or a salt thereof and derivatives thereof Naringenin or a salt thereof and derivatives thereof, hesperetin or a salt thereof and derivatives thereof, eriodictyol or a salt thereof and derivatives thereof, pinobankin or a salt thereof and derivatives thereof, aromadendrin or a salt thereof and derivatives thereof, Engeritin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof and derivatives thereof, Spira Oside, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosyl puerarin-4'-o-glucoside, 6-o-glucosyl puerarin, 3 '-Hydroxypuerarin-4'-o-glucoside,6-o-apiosyl-3'-hydroxypuerarin, etc.), γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) -glucoside, maltol -3-o- (6'-o-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or its salt and derivatives thereof (5,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ′, 4-trimethylellagic acid, 3,3 ′, 4,4′-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, Onji Saponin, Bacmond Saponin, Ruscogenin, Celicoside, Asia Side, hederin, senegin, benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4- Hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) ) Benzamide, 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyraline, cyproheptadine, triprolidine, dimethindene, ozagrel, isothipentyl, iproheptin, homochlorcyclidine, Alimemazine, bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, Zinc oxide, placenta (bovine origin, porcine origin, horse origin, sheep origin, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, okera extract, kofuyou extract, uncaria extract, Gaijicha extract, Kakiyuyu extract, Licorice extract, Gardenia extract, Kranigean extract, Clara extract, Koganebana (Ogon) extract, Wheat (wheat) extract, Rice (rice) extract, Koreaia extract, Sidwaya extract, Sunkukyu Extract, San Vitro Extract, Sun Penz Extract, Silane (Biac Kyu) Extract, Senkyu (River Cucumber) Extract, Senna Extract, Sempukuka Extract, Sentsutsusai Extract, Surigatin Extract, Nodake (Pre-Human) Extract, Barley (Yokuinin) Extract , Hamago extract, mi Bahamago (Vulgaris) extract, Hamamelis extract, Palm extract, Parietalia extract, Safflower (Safflower) extract, Muwa (Mulberry white skin) extract, Malvano jar (Bitter ginseng) extract, Purple squirrel extract, White squirrels extract, White wormwood extract , Yashajtsu extract, hongkong extract, bituminous (ground) extract, yuzuriha extract, scallop extract, scorpion extract and the like.

(2) Tyrosinase activity inhibitors Specifically, ascorbic acid or a salt thereof and derivatives thereof (phosphate-L-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate, 5- o-α-D-Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate Calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L -Ascorbic acid sulfate Tellurium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyrano Sil-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Ester sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl- L-ascorbic acid, 6-o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate Tercalcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid phosphate monoethanolamine salt, 6-o-alkyl Ascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanol Amine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, phosphorus ascorbate Acid cholesterol ester, palmitic acid-L-ascorbyl, isopal Mycinic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L- Ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexane Acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α- D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-malto Triosyl-L-ascorbic acid, L-ascorbic acid Trisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L- Ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinnamate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphoric acid diester, Scorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), hydroquinone or its salt and derivatives thereof (hydroquinone α-D-glucose , Hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Hexoses, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-a Five carbon sugar glycosides such as rabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L- Amino sugar glycosides such as glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D- Glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid Hydroquinone glycosides such as uronic acid glycosides Hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6- β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyra Hydroquinone hydroxyalkyl ether glycosides such as nosyloxy-1- (4-hydroxyphenoxy) butane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol, etc.) Kojic acid or a salt thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl- 5-Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hy Droxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate , Kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or its salts and derivatives thereof (α-tocopherol, β -Tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, Coferol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ -Tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D- β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L -α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-to Ferryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1- (Carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine , S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2- Hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ -Tocotrienol, δ-Tocotrienol, Tocotrienol acetate , Tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, ellagic acid or a salt thereof and derivatives thereof ( 3,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl -4-methyl-5-hydroxyellagic acid, amritoside, etc.), isonithrin A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobylidein and other isonitrile antibiotics, orthoric acid derivatives ( Orceric acid, Orceric acid ethyl ester orcinol, p-geranylorceric acid, p- Geranylorceric acid ethyl ester geranylorcinol, p-farnesylorselinic acid, p-farnesylorceric acid ethylester farnesylorcinol, p-dodecanylorceric acid, p-dodecanylorceric acid ethylester dodecanylorcinol , P-tetradecanylorceric acid, p-tetradecanylorceric acid ethyl ester tetradecanylorcinol, p-hexadecanylorceric acid, p-hexadecanylorceric acid ethyl ester hexadecanylorcinol P-undecanylorceric acid, p-undecanylorceric acid ethyl ester undecanylorcinol, p-tridecanylorceric acid, p-tridecanylorceric acid ethylester undecanylorcinol, p -Pentadecanylolselic acid, p-pentadecanylol Serine acid ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid, p-cyclohexylmethylorceric acid ethylester cyclohexylmethylorcinol, p -Hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol, resorcinol derivative (4-cyclohexylresorcinol), 3-hydroxyketone compound ( 1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis ( p-hydroxyph Nyl-m-methoxyphenyl) -2-hydroxypentan-4-one), 1,3-diketone compound (1,5-bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2,4-pentanedione, etc.), bishydroxybenzylamides, γ- Aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ-aminobutyric acid oleyl ester, etc.), hydrogen peroxide, zinc peroxide, placental extract, lucinol, silk extract, acacia Extract, acerola extract, lobster extract, fern birch extract, quellus extract, chestnut extract, turtle extract Kiss, Nazuna extract, Fujibama extract (Orchid) extract, Chamomile extract, Mulberry extract, Gardenia extract, Japanese cypress extract, Walnut extract, Clara extract, Artemisia extract, Honeysuckle extract, Yellowfin extract, Dokudami extract, Matsuhodo extract, Japanese oat extract, Odrianthus extract, Hop extract , Hawthorn extract, eucalyptus extract, Achillea millefolium extract, altea extract, cinnamon extract, bayberry extract, hamamelis extract, yamagua extract, bellflower extract, toshishi extract, goblin extract, shot dried extract, maize extract, senkyu extract, dokatsu extract, psycho extract , Bowfu extract, Hamaboufu extract, Ogon extract, Peony skin extract, Peonies extract, Gennoshoco extract, Kudzu root extract, Licorice extract, Pyramid extract, Aloe Extract, shouma extract, safflower extract, green tea extract, black tea extract, assen drug extract and the like.

(3) Melanocyte melanin production inhibitor Specific examples include lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentyl). Chromone, 2-heptyl chromone, 2-nonyl chromone, 2-hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7 -Methoxychromone, 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2 -Butylchromone, 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-penta Silkromon, 7-hydroxy-2- (1-ethylpentyl) chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D -Glucopyranosyl manur, 3-β-D-maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) ) Alanine, DL-N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL- N-valeryl-3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N -(3-Methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (4-Methylvaleryl) -3- (1- Butyl) alanine, DL-Nt-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3- (1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N-nonanoyl-3 -(1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- (1-naphthyl) ) Alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl-3- (1-naphthyl) Alanine, DL-N-Hexadecanoyl-3- (1-naphthyl) alanine, DL- N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl-3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N -Icosanoyl-3- (1-naphthyl) alanine, DL-N-acryloyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N-vinylacetyl-3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl)- 3- (1-naphthyl) alanine, DL-N- (4-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N -(3-Hexenoyl) -3- (1-naphthyl) alanine, DL-N- (2-methyl-3-pentenoyl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl-3 -(1-naphthyl) alanine, DL-N- (10-undecenoyl) -3- (1-naphthyl) alanine, DL-N -Linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) alanine, DL -N- (8-hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxydeca Noyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- (1 -Naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL -N- (m-Toluyl) -3- (1-naphthyl) alanine, DL-N- (p-Toluyl) -3- (1-naphthyl) alani DL-N- (1-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl)- 3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL -N- (2-picoliloyl) -3- (1-naphthyl) alanine, DL-N- (3-picoliloyl) -3- (1-naphthyl) alanine, DL-N- (4-picoliloyl) -3- ( 1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) alanine, DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3- (Phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL- N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester, DL -N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- (1 -Naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t-butyl Esters), benzolactam derivatives, indolactam derivatives, cedrol, guaiool, 1- (4-hydroxyphenthio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2- Methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxyphenone 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol, 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy- 5- (1-methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2 -Methoxyphenol, malvelin, feruginol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1, 4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] -1,4-pentadien-3-one, 1 , 5-bis [3-methoxy-4-hydroxyphenyl] -1,4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or derivatives thereof, alkylresorcinol or derivatives thereof (4-N-butyl Resorcinol, etc.), aristrone, caramenenes (caramenene, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenen, etc.), trans-umberic acid, N-α-benzoyl-L-arginine, N-α -Benzoyl-L-arginine ethyl ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-buten-4-olide, 2-hydroxymethylfuran, 2,5- Dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy-3-methyl-2-cyclopenten-1-one 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl-2-cyclopentene-1- ON, tetronic acid, pentanedione, iminodibenzyl (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.), dibenzocycloheptadiene (amitriptyline, amitriptyline hydrochloride) Salt, nortriptyline, noxypetitin, etc.), tetrahydrocopalol glycoside (ketotifen fumarate, labda-8 (17), 13-diene-15-ol, tetrahydromanur, tetrahydrocoparol, tetrahydrocoparol glucoside, tetrahydrocoparol Galactoside, tetrahydrocopalol maltoside, tetrahydrocoparo Arserobioside, tetrahydrocoparol maltotrioside, etc.), spiro ether compound, pyokeline, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, chlorpromazine, cyclandelate, 4-carboxymethyloxybenzoic acid, 4-carboxyl Methyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl) -1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) Benzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy)- 2-hydroxybenzoic acid, 4- (3-ethoxycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 4-methoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3 -(3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxyl Pyr-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- (2,2,6-trimethyl- 1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1 -Yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- (2,2,6-trimethyl-1 -Ill- Cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl-3-hydroxy-5- (2,2,6 -Trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -2-pentene, 2-hydroxy-4- Monosaccharides such as (2,2,6-trimethyl-1-yl-cyclohexane) butane, disaccharides or trisaccharide glycosides), escinol, parahydroxycinnamic acid-4- (2,2,6-trimethyl- Yl-cyclohexane) -2-butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6- Trimethyl-1-yl-cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-bu 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2- Keto-3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl -Lp-hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- ( p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphen Luglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenylglycine ethyl ester, N-acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp- Methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4-hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenyl Glycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl -Lp-methoxyphenylglycine, N-tert- Butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenyl Methyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycinamide, Lp -Hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p -Toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester hydrochloride, Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp-hydroxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester, etc., 1,3-diallylindane-2-carboxylic acids, stachybosines, pheophorbide derivatives, eleucerin, isoeleucerine or 4-β-hydroxyisoeleucerin, eleucerinol, spiroketal derivatives (2- ( 2,4-hexadiynylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-((4 -Methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexeni Den) -6,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4 Nonane, 2- (2-hexenyl) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] ] Nonane, 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo -2-octyl-1,6-dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadiynylidene) -1,6 -Dioxaspiro [4.4] non-3-ene etc.), Malvalic acid, phosphonic acid derivative or salt thereof, aspergillomalasmin, aminophosphonic acid derivative or salt thereof, diphenhydramine or salt thereof, pregnenolone or derivative thereof, lutein, farnesyl isopropanol derivative, hexahydrofarnesyl acetone, 4-benzoylamino-2 -Hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxybenzoic acid, 5- (1-naphthoylamino) -2 -Hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid, 4- (1-naphthoylamino) benzoic acid, 4 -(2-Naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenyl Minocarbonyl-2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxy Benzoic acid, 4- (2-naphthylaminocarbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl Isopropanol derivatives, borneol-p-hydroxycinnamic acid ester glucoside, borneol-p-hydroxycinnamic acid maltoside, borneol-p-hydroxycinnamic acid maltotrioside, cinnamic acid-4- (2,2,6 -Trimethyl-yl-cyclohexane) -2-butyl ester derivative, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone (2 ', 4'- Hydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2 ′, 4′-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2 , 4-Dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl ) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxyphenyl) -1-undecanone 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4-dihydroxyphenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2 , 4-Dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4-methoxyphenyl) -ethanone (2′-hydroxy-4′-methoxya Tophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxypropiophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-butanone 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- (2-hydroxy-4-methoxyphenyl) -1- Heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1 -Decanone, 1- (2-hydroxy-4-methoxyphenyl) -1-undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl)- 1-tetradecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydrido Roxy-2-methoxyphenyl) -ethanone (4'-hydroxy-2'-methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'-hydroxy-2'-methoxypropio) Phenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ′, 4′-dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ′, 4′-dimethoxypropio) Phenone), lactone derivatives (1,6-dioxaspiro [4.4] nonane-2,7-dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4-olide, 2-decen-4- Orido, 2-Nonen-4-Olide, 2-Heptene-4-Olide, 2-Undecen-5-Olide 2-decene-5-olide, 2-nonene-5-olide, 2-octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-decanolide, 4 -Methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl -5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nonanolide, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide, 2-allyl-4-undecanolide, 2-allyl-5- Decanolide, 2-allyl-4-nonanolide 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2-methyl-4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4 -Hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy-4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4- Pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide, 6- (2-hydroxyethoxy) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.) Ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methyl aloesol coumaroyl ester, 2'-8-C-glucosyl-7-methyl aloesol cinnamoyl ester, chloropyramine, anise extract, Aloe extract, Plover (Torex) extract, Onibasiri extract, Ebisugusa extract, Ketsumeishi (Keiko) extract, Ogi (Yellow cocoon) extract, Japanese yellow eagle extract, Prunus crisp (Kalakon) extract, Onamomi (Cotton ear) extract, Onionagira (Tempa) extract Extract , Cinnamon bud extract, Chinese prunus extract, Oshima cherry extract, Oyama cherry extract, bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion extract, palm extract, white banilis extract ) Extract, beetle extract, dragon beetle extract, beetle extract, toshishi extract, bean pod extract, pear extract, sagebrush extract, yarrow extract, cassava extract, dill extract, honey beetle extract, clam extract, human camellia extract ) Extract, swordfish extract, peony extract, floral blanca extract, humula extract, sagebrush extract, convolvulus extract, sandalwood extract, ganoderma biloba extract, swordfish (benuse) extract, king willow extract, red willow extract, cat willow extract , Incolyana extract, Kinu willow extract, Corian willow extract, Unryu willow extract, Miyama willow extract, Willow willow extract, Oba willow extract, Tairiku willow willow , Fox willow extract, dronox extract, bayberry extract, agave mid-autumn, blue agave extract, fuchlin agave extract, mitsumata extract, aonori extract, usba aonori extract, sujiaoori extract, hiraaoonori extract, bouonoori extract Daaonori Extract, Kombu Extract, Macombu Extract, Resilicumbu Extract, Hosome Kombu Extract, Mitsuishi Kombu Extract, Wakame Extract, Hirome Extract, Aowakame Extract, Hijiki Extract, Hibamata Extract, Umichiwa Extract, Usuba Umichiwa Extract, Kirebano Umichiwa Extract, Akabumi Uchiwa , Kona Uchiwa Extract, Okinawa Chiwa Extract, Usuki Uchiwa Extract, Etsuuki Uchiwa Extract, Spigot Rhinoceros Extract, Amakusa Giraffe A extract, giraffe rhinoceros extract, juniper ginseng extract, tsunomata extract, ibottsu no mata extract, malva tsunomata extract, hirakotoji extract, cedar extract, shikinori extract, kainori extract, hakugusa extract, uraboshiyahaz extract, sea urchin extract, ishimo zuku extract, misji kombu extract Atsumi-miscomb extract, Isomoku extract, Nagashima-moku extract, Shida-moku extract, Nejimoku extract, Narasamo extract, Mametawala extract, Tatsukuri extract, Yatsuma-Tamoku extract, Umitrano-o extract, Oobamoku extract, Fusuji-moku extract, Hahakimoku extract, Yoremo moku extract Extract, centipede extract, nuraxa extract, chronula extract, barley cadaver extract, pine tree Kiss, giant tiger beetle extract, sponge beetle extract, fushitsu nagi extract, himefu tsutsu nagi extract, hirohafu tsunagi extract, kurozozo extract, kubosozo extract, kanezozo extract, sozonohana extract, hazelwood mushroom extract, tila extract, camote de azafuran extract, hamaika extract , Poleo verde extract, Nabonegro extract, Datura extract, Matsubusa extract, Binanzaka extract and the like.

(4) Moisturizer Specifically, ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, hexylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, glycerin, erythritol, Pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol Polyalcohols such as le, lactitol, maltitol, sicilitol, laminitol, valienamine, validamine, and validatol, gum arabic, benzoin rubber, dammar gum, guaiac oil, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar or its derivatives , Casein, glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, trehalose, cordierbiose, laminaribiose, nigerose, cellobiose, sambubiose, neohesperidose, apiose, hammamose, streptose, Dihydrostreptose, 2-methylerythrose or its derivative, 2-methylerythronolactone , Mycarose, cladinose, acneose, alkanose, olivomai course, chromose, ebamiose, vinose, nogarose, billenose, nobiose, moenuronic acid, galosamine, cibirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose , Saccharides such as α-octose, trioxacalcinose, aldogalose, blastminosin or esters thereof, trehalose or derivatives thereof, D-mannosamine and derivatives thereof, isomaltoligosaccharide (panose), primeverose or derivatives thereof, dextrin, gelatin, Hyddenated with alkylene (C2-C4) oxide such as pectin, starch, carrageenan, carboxymethyl chitin or chitosan, ethylene oxide Xyalkyl (C2-C4) chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, 1, 3-β-glucan, 1,4-β-glucan, 1,6-β-glucan, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, carboxyethylcellulose sodium, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose , Hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polyethylene Polyalkylene oxides such as propylene oxide or cross-linked polymers thereof, carboxyvinyl polymers, polyethyleneimine, dermatan sulfate, water-soluble polymers such as keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid esters, glycerin fatty acid acetyl amino acid esters, pyrrolidone carboxyl Acid or salt thereof, polyaspartic acid or salt thereof, polyglutamic acid or salt thereof, polylysine or salt thereof, sodium lactate, hydantoin and derivatives thereof, Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone Amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, Rutamyllysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -sophoradiol, 3- o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -azuxapo Genol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [α-L-rhamnopyranosyl-β-D -Glucopyranosyl-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D -Glucopyranosyl-β-D-glucopyranosyl] -Azoxapogenol, etc.), Aoki (Aoki) extract, Aogiri extract, Kenashia Ogiri (Akairi) extract, Red ginger (Akasho) extract, Red clover extract, Akikara pine extract, Aguahe (Omanten palm) extract, Maruba asagao extract, Asagao extract, Achira extract, Brassica extract, Amazazuru extract, Amana extract, Ayuyu extract, Hagateto extract, Hydrangea extract, Ginseng extract, Sugimorii gate extract, Hosoa Oigata extract, Aogatei extract, Haribiyu extract, Aozulan extract, Amaranthus hippochondriax extract, Aristolomeria (Yurisuisen) extract, Arcana (alcanna) extract, Argarobo (cabbage) extract, aloe vera extract, rush (light heart grass extract), yew (first place) extract, strawberry extract, carob bean extract, Inazuna (Tailexi) extract, rice extract, dog mint extract, Wa-tobacco (Iwabuchi) extract, Iwahiba extract, Iwamatsu (rolling mushroom) extract, Wheat (Chibus tree) extract, Duckweed (Floam) extract, Usbenitachai extract, Usbunia mallow extract, Unyadegato (Unkaria) extract, Enokitake (Mushroom) extract , Eringi extract, pre-lotus eringi extract, ogatahouken extract, oguruma (civil engineering incense) extract, euglena (cereal essence) extract, oka extract, okazeli (serpentine) extract, okra extract, onidokoro extract, tokoro extract, nakadokoro (Hikai) extract, onionis extract, yuuko extract, persimmon extract, cantriso extract, gaku hydrangea extract, ginseng extract, gypsophila extract, ginseng extract, canniwa extract, carnation extract, gerbera extract, camcam ( (Mochamo) extract, color extract, oat extract, karin (Kiso) extract, Kawara Psycho (compulsed rape, tranquilized white grass) extract, kawajisha extract, kawaranadeshiko (stone bamboo) extract, Ezokawara nadeshiko (soba, buckwheat) extract, Kantarasaasa extract , Kikutanikiku extract, quinoa (quinoa) extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow, taiyanagi) extract, Kirangsou (golden grass weed) extract, guayule extract, Kusagisu Kazura (Tenmon winter) extract, Kudzu (Kakkon) Extract, Ginseng (Yellow Flower) Extract, Cupuasu Extract, Gumbai Tuna (Sekimei, Sekimeishi) Extract, Kemponashi (Kigushi) Extract, Geckavidin (Monthly Beauty) Extract, Kouren (Huo Ren) Extract, Coco Palm Extract, Cosmos Extract, Coconut Peel Extract, rice oil extract, konjac , Saffron (banban flower, west red flower) extract, sapodilla extract, sangre degrad (croton) extract, sanchinin ginseng (37 ginseng) extract, shea (carite) extract, cyanoki extract, shiitake extract (shiitake) extract, shimeji extract, Hinshimeji Extract, Shakashimeji Extract, Hatake-shimeji Extract, Oshiroi-Shimeji Extract, Beech-shimeji Extract, Honji-meshi Extract, Shirotamagi-taketake Extract, Shimokurene Extract, Saishin Extract, Cactus Extract, Janohige (Bakumon Winter) Extract, Shukukonkamiso Extract, Zhuozan Hydrangea (Tsuneyama) extract, White-faced butterfly extract, White-leafed adzuki bean (chicken bone) extract, Ginkgo biloba (Mizuka, Mizuka flower, Shencho flower) extract, Watermelon (Western phoenix) extract, Tin-thick cocoon (Xucho) extract, Subihiyu (Horse tooth soap, Horse tooth (Kenshi) extract, secekoku extract, cherry Sea cucumber extract, Japanese peony extract, Japanese peony extract, Japanese peony extract, Japanese peony extract, Japanese peony extract, Japanese peony extract, Cedron extract, Zenia oyster extract, celery extract, senshinren , Radish extract, Takasaburo extract, Tachidokoro (hikai) extract, Dahlia (Tenjiku button) extract, Talwei extract, Senkushi extract, Sojitsu extract, Chankapiedora extract, Tulip extract, Chorogi Extract, Tsukuritake (mushroom) extract, camellia extract, clover (lacquered licorice) extract, Tounabena (river cut) extract, corn extract, corn hair (southern cocoon) extract, Toxa (wood bandage) extract, t Rico (crustacean) extract, Turkish Kyary Extract, Solid Bean Extract, Vertical Spider (Tatame) Extract, Jujube (Otsuka) Extract, Navena (Continued) Extract, Nameko Extract, Namban Karamashi (Hemp) Extract, Smoke Boiled Extract, Nikuzukku Extract Extract , Haran extract, Pariurus (Haricus japonicus) extract, Balsamina (Villus serrata, bitter gourd) extract, Harlin Dou extract, Handaikai (Aoi sea) extract, Hygurmadori extract, Beet extract, Hiba extract, Sunflower Kiss, green pepper extract, Japanese apricot extract, Japanese pine bamboo (Kariharatake, Hiromatsutake) extract, Red pepper extract, Brazilian licorice extract, hazelnut extract, loofah extract, red snapper extract, scallop extract, broom extract, Chrysanthemum extract, Nendorus extract, Hahagigi Kokia (gem coconut) extract, spinach (Akansen, Acute pupa, Pseudograss) extract, Futaba extract, Jerusalem artichoke extract, Jojoba extract, Borage extract (borage) , Bordeaux extract, Hononiku (meat juju, daige) extract, Honsekkok (iron crust stone, sparrow mountain stone agate) extract, maca extract, macadamia nut extract, margaret extract ( Tengu) extract, Matsukasa extract, Matsuhodo (茯苓) extract, Matico (Cordon sillo) extract, Quince extract, Malene (Bilaud Muzusquid) extract, Manzanya (Andeskamitsuru) extract, Mizusobakaku extract, Mizuasagao (Ryutonakusa) extract, Green mint extract, wheat straw extract, munya extract, murasakikikibu extract, blue musselkib extract (Tsuruga, Tennasei) extract, Marronnier extract, Mokka extract, Lily extract, Ligan (Raimaru) extract, Lime extract, Rye extract, Pepper extract, Shallot extract, Apple extract, Gentian extract, Ganoderma (Branch nucleus) extract, Astragalus extract, Yokuinin extract, Mini Sasanishiki extract, Chlorella vulgaris extract, Chlorella pyrenoid extract, Chlorella ellipsoidia extract, Macrocystis pirifera extract, Yuikiri extract, Tosa kanori extract, Syringa extract, Amakusanori extract , Kawanori extract, Marimo extract, Motsukihie extract, Ezoyahaz extract, Habanori extract, Atlantic havanori extract, Cottontail extract, Aname extract, Sugime extract, Trolo kombu extract, Antokume extract, Tsuruarame extract, Kuroshiome extract, Nekoa shimbu extract, Ainu wakame extract, Chigaiso extract, Ezoi Shige extract, Yabanemoku extract, Trumpet extract, Uganomok extract, Joromoku extract, Hiemoku extract Tamanashimoku Extract, Honda Ward Extract, Sugi Moku Extract, Bovine Kenori Extract, Susbinori Extract, Akebono Mozuku Extract, Cypridina Extract, Fusanori Extract, Hosobanamino Hana Extract, Hanafnori Extract, Itafonori Extract, Kaginori Extract, Mirin Extract, Hosobamiri Extract Ezonameshi Extract, Ibaranori Extract, Kagibaranori Extract, Saidaibara Extract, Tachiibara Extract, Ogonori Extract, Tsurushiramo Extract, Bee-winged Crab Extract, Otsunori Extract, Akabagin Nanso Extract, Natto Bacteria Metabolites, Natto Extract Extract, Loofah Examples include water, birch (white birch) or red pine sap.

(5) Cell activator / metabolic activator Specifically, vitamin A group: retinol or its salt and derivatives thereof (retinyl unsaturation such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidonic acid, etc.) Fatty acid esters, etc.), retinal or salts thereof and derivatives thereof, dehydroretinal or salts thereof and derivatives thereof, retinoic acid or salts thereof and derivatives thereof, retinoic acid analogs (4-[[[8- (3,5 -Dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (4 -Methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3 , 4-Dimethylphenyl) -2-naphthalene Nyl] carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-isopropylphenyl)- 2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-fluorophenyl)- 2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl-2-naphthalenyl) carbonyl ] Amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid-like compound (4-[[ (5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) ) Amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5,6-dihydro- 5,5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) carbonyl] amino] benzoic acid 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[((5,6-dihydro- 5,5-Dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] Benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[((5-6-dihydro-5,5- Dimethyl-8-2-fluorophenyl) naphthalenyl] carbonyl] amino] benzoic acid 4-[[(5,6-dihydro-5,5,6-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,7 -Trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid , 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro-5,5 -Dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-[[[((5-6-dihydro-5,5 -Dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid, 4-[[[[(5,6-dihydro-5, 5-Dimethyl-8-phenyl) -2-naphthalenyl] methyl] oxy] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl ] Benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (2,4-dimethylphenyl))-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[ (5,6-dihydro-5,5-dimethyl-8- (4-methylphenyl))]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5- Dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) Enyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] methyl] benzoic acid, 4- [[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxybenzoic acid, 4-[[[((5,6-dihydro-5, 5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl ] Carbonyl] amino] -2-fluorobenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[((5,6-Dihydro-5,5-dimethyl-8) -2-naphthalene] -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5-6-dihydro-8- Phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[(5,6-dihydro-5,5- Methyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[(5,8,10,10a-tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] benzoic acid, 4-[[(1, 1-dimethyl-3-phenyl-1H-inden-5-yl) amino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid 4- [2- (1,1-dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene-5- (Carbonyl) amino] benzoic acid), carotene or a salt thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isozeaxanthin, rhodo Carotenoids such as sancin, capsanthin, crocetin, etc.), lycopene or a salt thereof and derivatives thereof, vitamin B group: thiamine or a salt thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisibtiamine, thiamine monophos) Fate disulfide, benfotiamine, chicotiamine, octothiamine, dicetiamine, fursultiamine, prosultiamine, astaxanthin thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mono Nucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosylnicotinamide pyrophosphate diester, 1-β-D-ribofuranosylnicotinic acid, etc.), pyridoxine or a salt thereof and Derivatives thereof (pyridoxine 3,4-dipalmitate, pyridoxine 3,4-dicaprylate, pyridoxine sulfate diester, etc.), pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, cyanocobalamin or salts thereof, and Derivatives thereof, cobalamins (methylcobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin etc.), folic acid or a salt thereof and derivatives thereof, nicotinic acid or a salt thereof and derivatives thereof, pantothenic acid or a salt thereof and derivatives thereof Biotin or a salt thereof and derivatives thereof, choline or a salt thereof and derivatives thereof, inositol or a salt thereof and derivatives thereof, vitamin C group: ascorbic acid or a salt thereof and derivatives thereof, vitamin D group: ergoka Cipherol or a salt thereof and derivatives thereof, cholecalciferol and a salt thereof and derivatives thereof (1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23, 24,25,26,27-pentanorcorecalciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23, 24,25,26,27-pentanorcorecalciferol, [1R, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23, 24,25,26,27-pentanorcorecalciferol, [1S, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23, 24,25,26,27-pentanorcorecalciferol, [1S, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23, 24, 25, 26, 27-penta Lucorecalciferol, etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group: tocopherol or a salt thereof and derivatives thereof, tocotrienol or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K Group: Phytonadione or salts thereof and derivatives thereof, menaquinone or salts thereof and derivatives thereof, menadione or salts thereof and derivatives thereof, menadiol or salts thereof and derivatives thereof, vitamin F group: linoleic acid or salts thereof and thereof Derivatives, linolenic acid or salts thereof and derivatives thereof, arachidonic acid or salts thereof and derivatives thereof, carnitine or salts thereof and derivatives thereof, ferulic acid or salts thereof and derivatives thereof, γ-oryzanol or salts thereof Salts and derivatives thereof, orotic acid or salts thereof and derivatives thereof, vitamin P group: rutin or salts thereof and derivatives thereof, eriocitrin or salts thereof and derivatives thereof, hesperidin or salts thereof and derivatives thereof, vitamin L Group: Anthranilic acid or its salt and derivatives thereof, adenylthiomethylpentose or its salt and their derivatives, vitamin U group: Methylmethionine sulfonium chloride or its derivative, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan , Lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine Ornithine, histidine or derivatives thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1-oxododecyl) -L- Histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl-L-histidine, N -Dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) and their sulfates, Amino acids such as phosphate, nitrate, citrate or amino acid derivatives such as pyrrolidone carboxylic acid, glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid, etc. -Hydroxy acids, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2 -Hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid, cerebronic acid, α-hydroxynervonic acid, Mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxyethanoic acid, 2- (3'-hydroxy -4'-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4'-hydroxy-3'-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphene 2) -2-hydroxypropanoic acid, 3- (4′-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ′, 4′-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, Ribbon acid, arabinonic acid, xylonic acid, lyxonic acid, aronic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, taronic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid Polyhydroxycarboxylic acids or hydroxypolycarboxylic acids (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, saccharide lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactohep Tonolactone, etc.), 2-keto acids (glyoxylic acid, 2-ketoethane) Methyl, benzoylformate, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctane Acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid, agaricinic acid, alolithic acid, pantoic acid, lactobionic acid, Hexulosonic acid, Photosensitizer 301, Hinokitiol, Pantothenic acid or derivatives thereof, Allantoin, Pentadecanoic acid glyceride, Linolenic acid or derivatives thereof, Eicosapentaenoic acid or derivatives thereof, Docosahexaenoic acid or derivatives thereof, Estradiol, Ethenyl estradiol , Antialol or its glycoside, rioniresinol or its glycoside, rhododendrol or its glycoside, platyphyronol or its glycoside, lactone compound (D-glucurono-6,3-lactone, α -D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D-galactonolactone, D-saccharide-1 , 4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octanoic lactone, nonanoic lactone, γ -Valerolactone, D-manninoic-δ-lactone, D-xylocic-δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl -DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof, 6-benzylaminopurine or derivatives thereof, 1,4-diazadicyclooctane, 2,5- Dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylosylglucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril , Trendrapril, perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycine, proteoglycan, lactic acid bacteria extract, lactic acid bacteria culture extract, lactic acid bacteria fermented milk extract, bifidobacteria extract, bifidobacteria culture liquid extract, bif Fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, yeast culture extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture extract, basidiomycetous extract, basidiomycete culture extract , Bacterial cell disruption extract, Bacterial culture fluid extract, Cultured human dermal cell disruption extract, Red sage extract, Fennel extract, Ezokogi extract, Barley extract, Okuri higotai ( (Zhengzhou Leopard, Indigo Ginger) Extract, Kagome Hypericum Extract, Hypericum Hypericum Extract, Dutch Jelly Extract, Dutch Honey Bee Extract, Silkworm Extract, Roman Chamomile Extract, Garcinia Extract, Kawarani Ginseng (Blue Mosquito) Extract, Kakiran Extract, Kiraya Extract , Orchid extract, ginkgo extract, calendula extract, sa Nelan (Ezosacaneran) extract, Sababagin orchid extract, Sawagurumi (Yamamomochi) extract, Shimotsumeso extract, Shajin extract, Plum extract, Prunus extract, Horsetail extract, Pineapple extract, Chinese squirrel extract, Hiragi (shooting) extract, Beech extract , Physalis (Torone) extract, maitake (maiko) extract, misohagi (senjuna) extract, mugwort (kibana) extract, mukuroji (life extension skin) extract, bean sprout, eucalyptus extract, yukinoshita (tiger ear grass) extract, Suabisimus extract, lettuce (Chisha) extract, aloe extract, dragonfly extract, tonka bean extract, gentian extract, burdock extract, shikon extract, carrot extract, hamamelis extract, hop extract, yakuinin extract, Japanese apricot extract, assembly extract, toki extract, Citrus extract, Achacha extract, Hypericum extract, Cucumber extract, Ginger extract, Rosemary extract, Parsley extract, Sanadagusa extract, Fukurimamiji extract, Raccoon extract, Oyster comb extract, Onikonbu extract, Gohei comb extract, Nagacombu extract, pea comb extract, large duck comb extract, rattle extract, lame rattle extract, benimozuku extract, hosobenimozuku extract, kagekinori extract, ezotosaka extract, silamo extract, birch extract and the like.

(6) Antioxidant Specifically, ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-L-ascorbic acid magnesium, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate phosphate, 5-o -α-D-Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium Salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L- Ascorbic acid sulfate aluminum Salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid potassium phosphate, 6-o-alkylascorbic acid phosphate calcium Salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid phosphate monoethanolamine salt, 6-o-alkylascorbic acid Phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt 6-o-alkyl ascorbic acid phosphate ester triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, cholesterol ascorbic acid phosphate Ester, Palmitic acid-L-Ascorbyl, Isopalmitic acid-L-As Colvir, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid- L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl , Oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl -L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L- L-ascorbic acid tetraisopal, such as ascorbic acid Mycinate, L-Ascorbate tetralaurate, L-Ascorbate tetra-2-ethylhexanoate, L-Ascorbate tetraoleate, 5,6-isopropylidene-L-ascorbate, Le, L -Ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate , L-ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl ] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid diester, ascor Binoic acid inositol binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearic acid esters, tocopherols or salts thereof and derivatives thereof (α-tocopherol) , Β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate , Tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β- Coferyl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α -Tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D- δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L -γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl- 6-Iroxy) propan-2-ol 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl ] Cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy)- 2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol) , Γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), dihydropyridine derivative (Methyl-3-phenyl-2-propenyl-1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nordihydro Guarectenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, sesamol, sesamorin, gossypol , Maritimaine, sulfretin, xanthene-2,7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin Etc.), phlorotannins, akebi (kitsutsu) extract, amacha (sweet tea) extract, Oolongcha extract, Dutch biloba extract, kanran extract, kumquat extract, gobishi extract, geno shochu (old lady's grass) extract, sesame extract, sesame cultured cell extract, sesame extract (rice ginseng) extract, rice bran extract, pomegranate extract, salamander (wild yam) extract, seiyou Pear extract, Daio extract, Tomato extract, Nanten extract, Noahami extract, Neubara extract, Paprika extract, Pistachio extract, Loquat extract, Betel wax extract , Japanese cypress extract, Japanese quince extract, Hosobaoguruma extract, Mao (mao) extract, Mimosa extract, Mebouki extract, Japanese black willow extract, Yanagidae extract, Watafujitsugi extract Extract, Akabau Examples include Miuchiwa extract, Hypericum extract, Clam extract, Clove extract, Melissa extract, Enmeso extract, Birch extract, Salvia extract, Rosemary extract, Southern natural fruit extract, Ginkgo biloba extract, Green tea extract, Clove extract and the like.

(7) Reactive oxygen scavenger / radical scavenger Specifically, superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and their Derivatives, curcumin or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4 '-o-β-D- (6 ”-galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene-4'-o-β-D- (2” -galloyl) glucopyranoside), chlorogenic acid phospholipid Esters, chlorogenic acid sphingosine esters and derivatives thereof, chlorogenic acid glycolipid esters, chloro Genic acid sugar ester, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-di) Ethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4 -Hydroxy-5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives , Akaminoki (logwood) extract, Akamegasiwa (red bud) extract, Akamino akane extract, Acacia serrata extract, Akane (Hakusai) extract, Hydrangea (hydrangea) extract, Abemaki extract, Fig extract, Ginkgo biloba , Asparagus extract, Japanese apricot extract, Japanese white extract, Japanese walrus extract, Estragon extract, Enju (Japanese cypress flower, coconut rice) extract, Japanese oak (Japanese coconut tree, Japanese maple leaf) extract, Japanese genus extract, Hippopotamus extract , Birch extract, cucumber extract Extract, perilla extract, white-tailed extract, chimpanzeo extract, catamendizo extract, peonies (glaze) extract, Japanese oak extract, Japanese oak extract, crape myrtle extract, zicopi extract, white-bellied extract, white clover (clover) extract, horseradish extract, black tea extract, green tea Kiss, camellia extract, tencha (bamboo tea) extract, tender eel extract, nani waibara (gold cherry tree) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nikki extract, yabnikay (cinnamon) extract, keishi (katsushi) extract, nozenkazura (Lyoen Flower) Extract, Lotus (Lotus) Extract, Chinese Cabbage Extract, Hadakagi Extract, Hanasuge (My Mom) Extract, Hermanus (Mykai Flower) Extract, Rose (Rose) Extract, Barbasco Extract, Spinach Extract, Beech Extract, American Beech Extract, Golden beech extract, European beech extract, Convolvulus extract, Hosobaokera (蒼朮) extract, Button (peony) extract, Mayoram (Annelida) extract, Melon extract, Oenothera extract, Snowy willow extract, Orchid extract, Lacanca extract, Rooibos extract, Naminohanae Examples include kisses, eucalyptus extracts, jujube licorice extracts, azusa extracts, basil extracts, mokko (wood fragrance) extracts, himefuuro extracts, and lemongrass extracts.

(8) Fat metabolism promoter Specifically, phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N -Butyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, Diprofylline, proxyphylline and oxtriphilin), Aotsuki-rafuji (wooden cocoon) extract, thistle extract, ale thistle extract, mallow thistle extract, scrub thistle extract, white thistle extract, large thistle extract, cacao extract, elcampuri extract, giant crab raft (Prevention) Extract, Gudget (莪 朮) Extract, Chrysanthemum Salmon Extract, Kyokyo (Kikyo, Kaki Root) Extract, Ivy Extract, Pepper (Pepper) Extract, Cola Acminata Extract, Sagiomodaka (Sawamata) Extract, Pomelo Extract, Sansyuyu (Yamamuro) Extract, Tsuba Rafuji Extract, Ootsuki Rafuji Extract, Choreimaitake (Amber) Extract, Clover Extract , Prickly pear extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puer tea (fuyu tea) extract, plum extract, boufu (windproof) extract and the like.

(9) UV protective agent / UV absorption accelerator Specifically, benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone) -5-sulfonate sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1 -(2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) ) -3-Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinnamoyl) -3 -Rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy-3-methoxy) Cinnamoyl) 3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-methoxyethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3-xylosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy) -4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy 4-methoxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, paraaminobenzoate) Glyceryl benzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, paramethoxy Sodium cinnamate, potassium paramethoxycinnamate, glyceryl mono-2-ethylcinnamate mono-2-ethylhexanoate), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acids Compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nico Acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranine, 6-dehydrocarbine, triazine derivatives (4,4'4 "-(1,3,5-triazine-2,4,6-triyltri Imino) trisbenzoic acid tris-2-ethylhexyl, etc.), phosphatidyl chromanol derivatives (1,2-dilaurolylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetra Methyl-6′-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1,2 -Dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-distearoylglycero-3-phospho-2' -Hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman 1,2-dialachidonylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1-myristoyl-2-palmitoylglycero- 3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl- 2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8 '-Tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman 1-stearoyl-2-myristoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1-stearoyl-2-pa Mitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman), L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate , Synoxate, Oxybenzone, Dioxybenzone, Octabenzone, Slysobenzone, Benzoresorcinol, Arbutin, Guaiazulene, Shikonin, Baicalin, Baicalein, Berberine, Neoheliopan, Chlorophylls, Xanthophylls, Escalol, Zinc Oxide, Talc, Kaolin, Anzokko (benzoic incense) Extract, hub extract, giant rush extract, asamido rush extract, kawajigusa extract, kawatake extract, medusa jellyfish extract, hassai extract, spirulina extract, iacacio extract, funorinouske extract, himetengususa extract, Examples include Hytengus extract, Oobusa extract, and Chinomori extract.

(10) Astringents Specifically, succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, Hamelian tannins, acer tannins, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagaro Gallotannins such as ilglucose, telimaglandin I, telimaglandin II, casarrictin, peduncraggin, geraniin, isotarkevin, granatin A, granatin B, ketulinic acid, keblagic acid, cajuarinin, nuphalin, procyanidin B-2, (Elatin tannins such as asinensin A, thiacinensin B, etc.), red grape extract, red bean extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezoba extract, Dutch strawberry extract, shrimp strawberry extract , Nawashiro Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidney Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle Extract Q) Extract, larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mud dandelion extract, vine azuki bean extract, tsurutsu Akebi extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Buttercup extract, Hagoromogusa extract, Castor extract, Grape extract, Prune extract, Veronica extract, Bisnaga extract, Bilberry extract, Mansuguru extract, Mitsugashi extract, Myrrh extract, Melissa extract, Examples include witch hazel extract, black willow extract, latania (chlamelia) extract, lemon extract, and daisy extract.

(11) Anti-inflammatory agents / interleukin production inhibitors / histamine release inhibitors Specifically, quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1, 4 -Diphenylpropylpiperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride , D-camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, Acid promethazine, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or salts thereof and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α- Trisodium glycyrrhizinate, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, β-glycyrrhizic acid mono Ammonium), glycyrrhetinic acid or a salt thereof, and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl α-glycyrrhetinate, stearyl β-glycyrrhetinate, pyridoxine α-glycyrrhetinate, β- Pyridoxine glycyrrhetinate, α-glycyrrhetinic acid glycerin, β-glycyrrhetinic acid glycerin, 3-succinyloxyglycyrrhetinic acid disodium etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenyl ethyl ether, etc. Panthenol or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexane) Carboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylamino Nomethylcyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid Potassium, potassium trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbonyla Calcium nomethylcyclohexanecarboxylate, magnesium trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyl Oxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3 , 5-Dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexane Boronic acid, sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonylamino) Methyl) calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine , Trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexane Carboxylic acid, sodium trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine-4'- Methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate potassium, Trans-4- (pyridine-4′-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans-4- (2 - Methyl silylethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate, astaxanthin dipalmitoleate) Ester, astaxanthin diheptadecanoic acid ester, astaxanthin dielaidic acid ester, astaxanthin diricinoleic acid ester, astaxanthin petroseric acid ester, astaxanthin vaccenic acid ester, astaxanthin eleostearic acid ester, astaxanthin punicic acid ester, astaxanthin ricinic acid ester, Astaxanthin Paris Naric acid ester, Astaxanthin gadoric acid ester, Astaxanthin-5-eicosenoic acid ester, Astaxanthin-5-docosenic acid ester, Astaxanthin cetolic acid ester, Astaxanthin erucic acid ester, Astaxanthin-5,13-docosadienoic acid ester, Astaxanthin ceracholic acid Ester, astaxanthin decenoic acid ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid ester, astaxanthin dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaenoic acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinoleic acid ester, astaxanthin dilinolene Acid ester, astaxanthin diara Donaxate etc.), Astaxanthin diglycerophosphate (Astaxanthin diglycerophosphate, Astaxanthin lyserophosphate palmitic acid, Astaxanthin lyserophosphatidylcholine palmitic acid, Astaxanthin lyserophosphatidylcholine DHA, Astaxanthin lyserophosphatidylinositol palmitic acid , Astaxanthing lyserophosphatidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid), steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [ 1- (2- (4- (1- (4,4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benz Midazole, 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [ 4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoate, 1- (2-ethoxyethyl)- 2- [1- (2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [ 4- (2- (4- (1- (2-hydroxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid), alanine derivatives or salts thereof (N -[3-Isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) ben Ilimino] -3H-thiazoline-5-carbonyl] -L-alanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5- Carbonyl] -2-methylalanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -N-methyl-L -Alanine etc.), thiazoline derivatives or salts thereof (3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3 -Methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate , Sulfated acid muco Sugar or salt thereof, sulfated dextran or salt thereof, fluoromethylhistidine or hydrochloride thereof, histidine methyl ester or hydrochloride thereof, licorice extract, sicon extract, age extract, propolis, eye (indigo leaf) extract, asenyaku (asen drug) extract , Avocado extract, Amadokoroko (Yamatake) extract, Amigasayuri extract, Baimo (shellfish mother) extract, Igakozorina (ground bile head) extract, Ibukitoranoo extract, Turmeric (Usu gold) extract, Echinashi (Hosobamurasakibarengiku) extract, Ouren ( (Yellow) extract, Oguruma (overturned) extract, Hypericum (Little cut grass) extract, Oniguri extract, Orange extract, Cassia extract, Chamomile extract (Tongweed) extract, Kawamidori extract, Kawara mugwort extract , Mountain return) extract, Gen Chiana extract, Koki Sekkoku extract, Kouhon (Kakimoto) Juice Extract, Indian Bodge Extract, Shukushamitsu (Sanjin, Shredded Sand) Extract, Juzudama Extract, White Minten Extract (Nami Tenshin) Extract, Ivy Extract, Psyllium Extract, Milfoil Extract, Hirosanega Extract, Takasago Rurihigotai (East Southeast Indigo) Extract, Takakawarabi (Spiral spine) Extract, Periwinkle Extract (Marika) Extract, Tamatsukitsu Rafuji Extract, Tonin Extract, Chigaya Extract, Toga (Winter Lion) Extract, Dokudami (10 Medicines) Extract, Parsley (Netherlands) Jellies ) Extract, Hanabishi (Shitushi, Shishitsuri) extract, Hamasuge (Katsukishi) extract, Hishi (Rishimi) extract, Bellows oyster extract, Japanese quail (South rattan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Pansy Extract, Hosoba Abakugi (bittersweet) extract, Mizurutennansho (Tennansei) extract, pheasant (fruit) extract, miracle fruit extract, Munoki extract, peach (peach) extract, cornflower extract, cornflower extract, mistletoe (willow parasite) extract, Yabukouji (purple gold beef) extract, sagebrush extract, mugwort (bamboo leaf) extract, rosemary (mannenrou) extract, shimeji hagi extract, ft juzumo extract, tamajuzumo extract, mizojusmo extract, urushigusa extract, iwahige extract, Akamoku extract, togemoku extract, red Extract, Maruba Akaba Extract, Haribare Extract, Dulse Extract, Yuna Extract, Belladonna Extract, Boron Extract, Harunire (Crustacea, Birch Skin, Bamboo Leaves) Extract, Aozulan Extract, Sakaneran Extract, Sababagin Ran Extract, Husambird (variety and origin) Seeds) extract, valerian extract, primrose extract, sensu extract, kyonin extract, honeysuckle extract, tokyo extract, fennel extract, peppermint extract, and the like.

(12) Antiseborrheic agents Specifically, chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa (Asakojin) extract , Nettle extract (continuous), Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebassikis, scallop extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, Tokinsenka (marigold) Examples include extract, Chinese yam extract, yam extract, nosen-halen extract, Japanese cypress poppy (sect winter flower, winter winter leaf) extract, japonica extract, giant kelp extract, hijirimen extract, proboscis extract, hyus banori extract and the like.

(13) Antibacterial agent Specifically, acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T , Salicy powder, iodine compound, iodoform, 1-alkylcarbapenem compound, N-substituted azepane derivative or salt thereof, sorbic acid or salt thereof, propionic acid or salt thereof, salicylic acid or salt thereof, dehydroacetic acid, parahydroxybenzoic acid ester 2-keto-3-deoxyoctanoic acid fatty acid esters, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ester Ter, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc Pyridione, chlorobutanol, isopropylmethylphenol, elemol, tiveverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxy Ethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, Benzethonium chloride, methyl rosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, jamal, photosensitizer 101, photosensitizer 201, photosensitizer 401, N-long chain acyl basic amino acid derivatives and acid addition thereof Salt, zinc oxide, hinokitiol, propolis, kudin extract, agi extract, asunaro extract, alpinia extract, katsudai (suzukukku) extract, Inubuyu (Honagainbuyu) extract, Aogateito Extract鈎) Extract, Kahoku Salamander (蜀椒) Extract, Chamomile Extract, Kinakiki Extract, Red linden extract, Yellow Spider Extract, Caraway Extract, Betel Extract, Kumazasa Extract, Cranberry Extract, Grapefruit Extract, Celosia (Chicken Flower, Chicken Crown) ) Extract, bay bay laurel extract, Koushinbara (monthly flower) extract, copaiba balsam extract, mountain cherry extract, ed pear extract, Miyaza cherry extract, Yoshino cherry extract, Kasami cherry extract, Kanza cherry extract, sugar beet Extract, Sarasinashouma (Hemp) extract, Shimushi (Mikoshi) extract, white birch extract, cinnamon extract, sorrel (acid mimic) extract, dandelion extract, Nezu (Pine pine) extract, Japanese mint extract, Japanese wild mint extract, Soka ( (Grass) extract, onion extract, chicory extract, ginseng extract, tsuruna extract, tokon extract, leek extract, leek extract, peach extract, patchouli extract, ganbanana ( Sarcophagus, vine pearl shahua) extract, hinoki extract, pimenta extract, hirohaokinagusa (bald eagle) extract, blackberry extract, hop extract, macri (marine herb) extract, magnolia sprengeri extract, mizokakushi (half-sided lotus) Extract, bee extract, purple (purple) extract, moso bamboo extract, pokeweed ( Terrestrial) extract, yucca extract, euglena extract, lavender extract, forsythia extract, syringen extract, psyllium extract, tochaka extract Usuhigusa extract, Iroro extract, Ishige extract, Arame extract, Tamaitake extract, Tambanori extract, Katanori extract, Sakuranori extract, Fuji Matsumo extract, Kawamokuzuku extract, Aokawamokuzuku extract, Himekawa Mozuku extract, Yakuchi (Michichi) extract and the like.

(14) Blood flow promoter / vascular stimulator Specifically, tocopherol or a salt thereof and a derivative thereof, tocotrienol or a salt thereof and a derivative thereof, cephalanthin, carpronium chloride, an eugenol derivative (acetyleugenol, methyleugenol, methylisoeugenol) , Ethyl eugenol, ethyl isoeugenol, eugenol salicylate, etc.), minoxidil, chili pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil , Ikutamol, α-borneol, cyclandrate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract, Loe extract, Gentiana extract, Toki extract, Ashitaba (Tomorrow) extract, Arnica extract, Yukiyara (Sanryo) extract, Himewiku extract, Citrus unshiu (Chest) extract, Toucan beetle (coconut) extract, Oyster extract, Kaki extract, Kina extract, Ginseng hen extract, pine moth (horse whip grass) extract, goby ginseng extract, kohone (river bone) extract, burdock (beef bowl, beef coconut) extract, scallop (mountain curd) extract, syringan ginger extract, ginger (ginger) extract, ginger (ginger)菖蒲, Sone) extract, Hawthorn extract, Seburi extract, Daidai extract, Tanjin extract, Thyme extract, Chikutsutsujinjin (Takebushi ginseng) extract, Tsurugokudami extract, Tsurunjinjin (Yoteba ginseng) extract, chili pepper (banban) extract, touki (toll) Eki , Scotch moth extract, Natsumikan extract, elderberry (bone grafting) extract, hazelnut (coconut) extract, ashidokoro (roth root) extract, mint (light load, thin load leaf) extract, Hamaboufu (beach wind) extract, Higotai extract, Examples include Fujimodoki (Chrysanthemum sakura), Black currant extract, Bodaiju (Bamboo tree) extract, Merirot extract, Yuzu extract, Loquat extract, Japanese jelly extract, Hibiscus extract, Rosehip extract and the like.

(15) Antiandrogens Specifically, follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, 4 ′, 5,7-trihydroxy-8-prenylflavanone, 4 ′, 5,7-tri Examples include hydroxy-8-prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporic acid and the like.

(16) Inhibitors of structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc.) / Structural proteolytic enzyme expression inhibitor Specifically, adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, pentanetriol-9-adenine and its Phosphate adducts, etc.), carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid, 1,10-decamethylene Dicarboxylic acid), Zumaric acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor-5 α-7,9 (11) -lanostadien- 3,24-dione, ubiquinone, plataquinone, yuglone, shikonin, quinizarin, alizarin, abietin, levopimar, betulin, α-amylin, catechin compounds (catechin, epigallocaequine, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin ram Nopyranoside catechin, etc.), diisopropyl fluorophosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate dimethyl, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4 -Hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid dimethyl, (2R, 6R)- 2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) Oxy) heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4- (tert-Butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6 -Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,4 , 6-Trihydroxyheptane-1,7-dicarboxylic acid dia N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid Diamide, (2S, 6S) -2,6-Dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, (2S, 6S) -2,6-dihydroxy -4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7 -Dicarboxylate dimethyl, (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'- Bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2 R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -Amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -Tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chloro Biphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, [1- [4- (4-fluoro Benzyloxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -cal Isopropyl isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylfuropionamide, 3- [4- (4-fluorophenoxy) -benzenesulfonyl] -2 , N-dihydroxyfuropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)-[2- (2,2 -Dimethyl-1-methylcarbamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl] -N-Hydroxypropionamide, N-Hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Buddlesia extract, Dianthus extract Shishi (Yamako) extract, Calahoo (Koh-Pak) extract, Guava extract, Goshishi (Gomicho) extract, Shazenso extract, Rose rose extract, Hypericum periwinkle extract, Octopus (Traditional) extract, Hinata tadpole (cow knee) extract, Honoki ( (Japanese Koshoku, Park) extract, American grape extract, European grape extract, Yama grape extract, Mandarin extract, Mishima psycho (Shibahu) extract, Ogon extract, Hypericum extract, Clara extract, Mulberry extract, Keihi extract, Genpachi extract, Comfrey extract, Salvia extract, Atlantic elder extract, body sage extract, button pi extract, Aozuzuran extract, Sakaneran extract, Sasabagin orchid extract, Chinese cabbage extract (including varieties and origins), blue-green agave extract, sisal extract Adenophortriphylla extract, and the like.

(17) Structural protein synthesis promoter Specifically, ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3,5,5-trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7- Dimethyl-6-octenyloxy) -2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2- Methyl hydroxy-5- (3,5,5-trimethylhexyloxy) benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate, Methyl 2-hydroxy-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy)- 2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2-hydroxybenzoic acid Acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2- Hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) -2- Hydroxybenzoic acid, 4-N-hexyloxy-2-hydroxybenzoic acid, 5-N-he Siloxy-2-hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) 2-hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, sodium 4- (2-ethylhexyloxy) -2-hydroxybenzoate 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 4-[(2E) -3,7-dimethyl-2,6-octadi Ethyl enyloxy] -2-hydroxybenzoate, 5-[(2E) -3,7 dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 3-[(2E) -3,7 -Dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -5- Ethyl droxybenzoate, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxyethyl benzoate, 4-[(2E, 6E) -3,7,11- Methyl trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzoate, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid ( 2E) -3,7-dimethyl-2,6-octadienyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 5-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid Acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoic acid, 2-hydroxy-4-[(2E, 6E) -3,7,11- Trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxy Benzoic acid, 2-acetoxy-4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3, 7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, [dimethyl -2,6-octadienyloxy] benzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4- Dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyoctadecyloxy) benzoic acid, 3- (11-hydroxyundecyl) Xyl) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 4-[(2E)- 3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4 -[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl-9- (2,6,6-trimethyl- 1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5,7,8-tetramethyl-2- (4, 8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] Benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyloxy) benzamide, 4- (2- Tilhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11-hydroxyundecyloxy) benzamide, 4- (10- Hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] Benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-di [(2E) -3, 7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl-2,6-octadienylamino] benzamide, 4 -[N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadienyl]] aminobenzamide, N- (2-hydride Roxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N, N-diethyl-4-[(2E, 6E ) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, pea extract, tossed beetle extract, ikanoashi extract, hosobonori extract, novori extract, igisu extract, keigi extract, harii gi extract , Hanegis Extract, Usbawa Egret Extract, Moray Rugosa Extract, Futrush Extract, Hana Willow Extract, Willow Extract, Motsuyu Rena Extract, Veneer Collagen Extract, Moth Willow Extract, Saba Bayanagori Extract, Wasabi Extract, Merbow Extract Etc.

(18) Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor Specifically, anacardic acid or a derivative thereof (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6 -Pentadecatrienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether 6-pentadecatrienyl salicylaldehyde butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde Propyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6-penta Decatrienyl cinnamic acid, 2-butyl ether-6-pentadecatrienyl cinnamic acid, 2-methyl ether-6-pentadecatrienyl cinnamic alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamic alcohol , 2-propyl ether-6-pentadecatrienyl cinnamon alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamon alcohol, etc.), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol, Isoxanthothymol, gucciferon, etc.) , Extract, narco lily extract, scallop extract, yellow orchid extract, oregano extract, fern extract, prawn extract, crow birch extract (half summer) extract, pheasant extract Skin) extract, goshyu extract, senega extract, sendan extract, tamarind extract, tarragon extract, ginkgo biloba extract, bee extract, daisy extract, mirabaran extract, himebara extract, Mockin Extract, Laurel Extract, Yabu Cycad Extract, Anaaosa Extract, Macrocystis Integrifolia Extract, Neocitus Ruet Keana Extract, Nettle Extract, Pterosa Extract, Pterosa Extract, Yatabegusa Extract, Cyperus Extract, Ezotsu no Matae Kisses, Swallowtail extract, Fusiwa ivy extract, Hanemo extract, Mill extract, Chromel extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Orochi nori extract, Mafnori extract, Grape leaf extract, Salamander extract, Astragalus extract etc. are mentioned.

(19) Mucopolysaccharide synthesis promoter More specifically, stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, mint extract, breadfruit Extracts Examples of the extract include black beetle extract, nezushinosakamodoki extract, yusora extract, etsukinotosakamodoki extract, nankaitosakamodoki extract, himetosakamodoki extract, and the like.

(20) Intercellular adipogenesis promoter / intercellular lipid state improving agent Specifically, phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, diacylphosphatidylcholine, Diacylphosphatidylethanolamine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid , 2-Azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosyl Ceramide, Galactosylceramide, Cerebroside, Phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soy lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-keto Lesterol oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (galaose, ganglytriaose, ganglitetraose , Globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyferrin, 3-deazaadenosine, carboxysamide Derivatives, Inositol polyamines, Sialic acid, Triterpenic acid derivatives, Lactose, Lactosamine derivatives, Sulfated chitin derivatives, Albumin, Panax ginseng extract, Tochiban ginseng extract, Tiger lily extract, Sasayuri extract, Hakata Yurieki And dairy extract.

(21) Keratolytic agent / stratum corneum exfoliation accelerator Specifically, tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean (shado) Extract, lentil extract, chickpea extract, mungbean extract and the like.

(22) Plasminogen activator antagonist inhibitor Specific examples include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

(23) Maillard reaction inhibitors Specifically, aminoguanidine, flavanones (naringin, naringenin, naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin Tannic acid, tannic acid, tannic acid, geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, trigalloyl glucose, pentagalloyl glucose, digalloyl quinic acid, trigalloyl kinin Acid), 2-hydroxyphenylalkylamine derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta- 2, 4, 6- Phosphonic acid, 3- (3,5-dimethoxy-4-hydroxyphenyl) propenohydrazide, N′-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or a salt thereof, Root) extract, sandalwood extract, red-crowned wrinkle extract, persimmon (including moth) extract, mulberry extract, Hypericum perforatum extract, camellia extract, garage extract, yaba santa extract, rosehip extract, asunaro extract, itadori extract, icha yak extract, kei Kanka extract, Birch extract, Hawthorn extract, Achillea millefolium extract, Cod extract, Dokudami extract, Tormentilla extract, Bakumondo extract, Hiba extract, Grape extract, Michiganagi extract, Mukuroji extract, Karin extract, Mokka extract, Roman chamomile Kiss, and the like.

(24) Testosterone 5α reductase activity inhibitor / papilla activator / hair growth promoter Specifically, γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino) -β-hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexa Decyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino -β-hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxybutyric acid ester Acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide) , Myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethyl) Aminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl Imidazolinium betaine), pyrimidine N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine-3 -Oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2 -Amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino- 6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide, 2- Amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamy -4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrosinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5- Piperidino-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5-bromo-6- (1 -Pyrodinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6-piperidinopyrimidine-3 -Oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide monohydrochloride, 2 -Acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) Pyrimidine-3-oxide 2,4-diamino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide 2,4-Diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine -3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine -3-oxides, etc.), p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, monopentadecanoic acid glyceride sulfate Glyceride sulfate, monopentadecyl glyceryl ether sulfate, 1-o-hexadecyl-2-o-methyl glyceride Roll, 1-o-octadecyl-2-o-methylglycerol, 1-o-oleyl-2-o-methylglycerol, acetylcarnitine or a salt thereof, geranylgeranylacetone, a hydroxamic acid derivative or a salt thereof, Gingerone glycosides, benzeneoxyacetic acid derivatives ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid, etc.) , Isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-2, procyanidins B-2, procyanidins B-3, Procyanidin C-1 etc.), Aracaci extract, Angelica extract, Apricot extract, Hon apricot extract, A Yakuso (one herb) extract, Enishida extract, psyllium (carrot, carp grass) extract, psyllium shabushi extract, olive extract, Giant pufferfish extract, seisei extract, calla uri extract, Chinese chrysanthemum extract, chrysanthemum extract, striped peony extract, ginseng Extract, Catalpa extract, Kukui nut extract, Camphor tree extract, Kubaba extract, Black-bellied red extract, Snapper extract, Snapdragon extract, Snapdragon extract, Kippi extract, Japanese beetle extract, Cilantro extract, Kobushi extract, Mokuren extract, Sanekazu extract , Binankazura extract, Matsubusa extract, Colombo extract, Conslango extract, Southern squirrel extract, Sweet potato extract, Sanebuto jujube extract, Sandskon , Potato extract, Shishigashi extract, Sanshishi extract, Coriander extract, Stevia extract, Takatodai extract , Nurde (penta) extract, Hakamauraboshi (bone crushing) extract, Hakkomokuren extract, Smoke squirrel extract, Toagokushida extract, Hakkogusa extract, Hyacinth carrot (participant) extract, Mangosteen extract, Myouga extract, Melaleuca extract , Yachabushi (Yagari) extract, Himeya Chabushi extract, Obayaya Shabushi extract, Yakumoso extract, Yamahannoki (Yamatake) extract, Longan (Yongan) extract, Locon (Yoshi, Sone) extract, Logwood extract, Lantana extract, etc. .

(25) Hair matrix growth inhibitor / hair growth inhibitor Specifically, phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, Examples include Mestanolone, Ichihatsu (primary) extract, Kashiwa extract, Kantou extract, Sanjiko extract, Shiramo extract, Sowjutsu extract, Hitobushi licorice extract, Fritillary extract, Iris japonica extract, Iris extract and Yoremok extract.

(26) Hair swelling agent / hair protecting agent Specific examples include ethanolamine, urea, guanidine, silicones, blueberry extract and mango extract.

(27) Odorous substance eliminating agent Specific examples include inondo extract, elemi extract, danmar extract, vanilla bins extract, pine extract and the like.

  Specific examples of ingredients derived from plant-based materials used as additives include Aokazura (Seifu-to) extract, Aotenma extract, Akasuguri extract, Aquine (crust) extract, Aguay guassu extract, Abiul extract, Abiurana Extract, yellow sapote extract, ylang ylang extract, phalaenopsis extract, uba tea extract, suzuran extract, unboku extract, elderberry extract, sasayukiyuki extract, sasanoyuki extract, tossed cactus extract, ohia catechu extract, onoelan extract, cynomolgus (Kinshato) Extract, Karaya Extract, Garyu Extract, Kawaratake Extract, Candelilla Extract, Canna Extract, Kidachi Pepper Extract, Kimenkaku Extract, Cabbage Extract, Kiraja Saponaria Extract, Ginsekai Extract, Kimbusen Eki , Guapeba vermelha extract, kugenumaran extract, cousberry extract, cutiti river extract, curkrigo latifolia extract, black moth (rescue) extract, cucurian extract, sapotea mariyo extract, salmon berry extract, sarancito (sand indigo) (Sashimi) extract, Sancactus cactus extract, Sansakuyo Sou extract, Shunran extract, Shozukku extract, Shirobanatsuta extract, Cinconacill sylbra extract, Swimberry extract, Star apple extract, Sulgaran extract (Oran) extract, Red pine extract, Seiyo Cypress extract, scallop extract, mistletoe extract, sennin cactus extract, senboku extract, elephant shoot extract, prunus extract, some mono-potato extract, dark sea Cherry extract, Prickly pear extract, Choco nostay extract, Korean mugwort extract, Azalea extract, Azalea extract, Azalea extract (Duckweed) extract, Duberry extract, Clover extract, Tragacanth extract, Triacanthus extract, Nai Zeria berry extract, Rapeseed extract, Plover-dough extract, Pau doce extract, Hakukayumatou extract, Hakuru berry extract, Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, Dinosaur extract Extract, Brazilian carrot extract, Braignen extract, Frucereria extract, Blond psyllium extract, Hetsukaran extract, Henken extract, Berry extract, Persair extract, Pervianburg extract, Pele Kia Grandifolia extract, Boysenberry extract, Hosairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, Whataberry berry extract, Masalan ubaba extract, Masala nuba de ceara extract, Masheira de Boyi extract , Matta Oryo Extract, Mulberry Extract, Green Zapote Extract, Murasaki Corn Extract, Megacansa Opuntica Extract, Mokukirin Extract, Momijidaio Extract, Morello Cherry Extract, Yakawa Murasaki Imo Extract, Cornflower Extract, Rurita Thistle Plant extracts such as Xinjiang Indigo Ginger Extract, Red Currant Extract, Red Pitaya Extract, Lemongrass Extract, Wax Palm Extract, Logan Berry Extract, etc. I can get lost.

  Specific examples of the ingredients derived from plant-based materials used as additives include Dunaliella genus Dunaliella extract, Chlorococcus chlorococcus extract, Quaternium genus Kuwanomimo extract, Volbox genus genus sunflower extract, Volbox genus Volbox extract, Palmera extract, Jupiter extract, Aomydra spp. Extract, Papilio spp. Extract, cassava extract, cicada extract, colecaete extract, cicada extract, duckweed extract, crayfish Green extract such as Loa extract, Kunshomo extract, Sumiremo violet extract, Hosimidro extract, Fuchinashimidro extract Iso Grape Extract, Isogawara Isogawara Extract, Kurogashira Gunsen Kurogashira Extract, Kashirazaki Kashirazaki Extract, Muchimo Muchimo Extract, Muchimo Hiramchimo Extract, Muchimo Keribergusa Extract, Amygusa Sakibiro Amiji Extract, Common Sasa Common Gusa Extract, Jigamigusa Genus Jigmyusa extract, Nami-makura genus Hirami-makura extract, Someraceae genus Someraceae extract, Navaimo genus Navarimo extract, Chasomen moth Chasomen extract, Nagamatsu sp. Nagamatsu sp. Rabbit extract, Rhizoma spp. Weeping Manori Extract, Weeping Crab Extract, Fritillaria Fistula Extract, Cultivation Crane Extract, Frog Brown algae extract such as genus Chlome extract, Chrysanthemum genus Chrysanthemum extract, Nerecomb genus Nerecomb extract, Spirella spp. Extract, Amanori Tasa Extract, Amanori Firitasa Extract, Amanori Benitasa Extract, Rhodocorton Mirnoveni Extract, Kona Hada Hyakona Hada Extract, Kona Hada Yokore Kona Hada Extract, Kona Hada Ao Naha Hada Extract, Rhizobium Genus Thrips Gassilori extract, pine genus pine extract, Nisefusanori genus Fusanoori extract, Sodegarami genus Sodegarami extract, Hirohata Tadaki genus Hirohata Mitaki extract, Amanita Nambugusa extract, Tengususa spp. Pseudomonas spp. Crabnote extract, Coral spider coral extract, Centipede spruce cadaver extract, Centipede spruce extract, Centacum spp. Denori genus centipede extract, centipede genus vine extract, centipede genus fudarak extract, genus genus marbahudarak extract, cypress genus cypress extract, arabe genus madder extract, quince genus chabo kintoki extract, kinto genus kintoki extract Pine extract, Kintoki-Hitomatsu extract, Kintoki-Bushiki-toki-toki extract, Kintoki-tsunomu-kade extract, Kintoki-toga-kinki-toki extract, Kintoki-suji-kadeki extract, Kakera-to-spotted oakkin-toki extract, Nagaobane-genus Nagaobane extract, Kalekigusa-kalekigusa extract, Kinuhada Genus Kinu Hada extract, Tsukasanoori Enashikarimenia extract, Tsukasanoori Otsukasanori extract, Tsukasanoori Hanagatakarimenia extract, Ho Genus honoo extract, genus genus genus genus extract, genus genus genus Usugineu extract, genus genus genus genus urchinum extract, venus nago genus venus nago extract, skunk genus suskake beni extract, okaramusa genus genus extract, isomocca genus isomokka extract, pheasant genus pheasant extract Isodantsu Isodantsu Extract, Atsubanori Atsubanori Extract, Ogonori Mizoogonori Extract, Ogonori Beniogonori Extract, Ogonori Ukureshinori Extract, Ogonori Murasakibibanori Extract, Ogonori Sinkaibanori Extract, Ogonori Extract , Ogonori genus Katagogonori extract, Ogonori genus Ryukyu Ogonori extract, Ogonori genus Ogonori extract, Ogonori genus Ituginu extract, Ogonori genus Yumi Ganoderma extract, Ogonori genus Kubileogonori extract, Ronus spruce genus extract, Ronus spp. Scorpion genus extract, Rhizoma genus extract, Sedum genus extract, Scots squirrel extract, Scutella genus extract, Scutella genus extract, Scutella genus extract, Scutella genus extract, Fukutsunagi extract Hanaedae extract, Hirata goat Hirata goat extract, Dulse scorpion extract, Dulse anadalus extract, Webagus webag Extract , Konohanori extract, Suzushironori extract, Usbeni spp.usbeni extract, Hasujiginu spp. Heius vanori genus Suusus banori extract, Haius banori genus Hyus banori extract, Usubanorimodoki genus Usubanorimodoki extract, Ayanishiki genus Ayanishiki extract, Goatium Aeginu Extract, Dadia Enasidadia Extract, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Dajimodaki Dajimomodoki Extract, Makuri Makuri Extract, Hanegusa Hanagusa Extract, Hanegusa Kehanegusa Extract, Kozanemo Kozaemone Kozaemone Cozanemo sp. Red algae, such as Isobasho genus Isobasho extract, Ideukogome genus Yukogome extract, Ochimozuki Okichimozuku extract, Chisujinori genus Chisujinori extract Extracts, Shajikumo Extract, Shirahamamo Extract, Hoshitsurimo Hoshitsurimo Extract, Rikunotumnusu Extract, Flasmocha spp. It is done.

  Specific examples of ingredients derived from animal materials used as active ingredients or additives include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or degradation products thereof. , Bovine or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysate, elastin, elastin hydrolysate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk Proteins and degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation thereof Products or derivatives thereof, skim milk powder and decomposition products thereof or derivatives thereof, lactoferrin or decomposition products thereof, egg component, fish Examples include meat degradation products and nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) and the like.

  Specific examples of components derived from microbial materials used as active ingredients or additives include yeast metabolites, yeast extract extracts, bacterial metabolites, bacterial extract extracts, metabolites such as molds or mushrooms, actinomycetes metabolites , Extracts such as mold or mushroom, actinomycetes extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice bran, birch) fermented extract, euglena extract or a decomposed product thereof or water-soluble derivatives thereof, raw milk Or the lactic acid fermented product of skim milk powder, a trehalose, its derivative (s), etc. are mentioned.

  In addition, as a plant, animal, or microbial material, any site, cell, tissue, organ, metabolite, etc. derived from a transgenic body or a cell fusion can be used. Furthermore, it is obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cell etc.), undifferentiated cell group, cell group in the middle of differentiation, and their metabolites can also be used.

  Specific examples of natural ingredients used as active ingredients or additives include seawater such as deep seawater, for example, sea salt, seawater dried products, dead sea or Atlantic or Pacific seawater (salt salts). Sodium, magnesium chloride, potassium chloride, etc.), sea mud or mud (Fango), for example, Italian mugo, German fungo, Eifelfango, Freiburg Fango, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, (Aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water) , Saintoku stone, natural smectite, bentonite, hectorite and the like.

  Extracts derived from plant-based raw materials, animal-based raw materials, microbial-based raw materials, and other natural product raw materials used as active ingredients or additives are processed in a conventional manner according to the product type and form to be added (for example, pulverized) , Milling, washing, extraction, degradation, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. It is only necessary to select and use any of various materials.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol, Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or water-containing polyvalent Various organic solvents such as alcohol, acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, and acids prepared with appropriate normality (hydrochloric acid, It is desirable to use one or a mixture of two or more selected from sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it can be used alone or in any mixture with water. What was extracted may be sufficient.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, Proteolytic enzymes (proteases) such as pancreatin, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular , Pectinase, polygalacturonase, dextranase, pralanase and other polysaccharide-degrading enzymes, chicken egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase Examples thereof include cell wall lytic enzymes such as oxidase, chitinase, and kilosanase. In the case of using an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, and the like can be set arbitrarily, but it is particularly preferable to set the optimum value for the enzyme used.

Fermentation or metabolic conversion by microorganisms can be carried out by inoculating and growing at least one or more microorganisms on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Amphierna, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ascotrichosporon, Ashbia, Ashbya Genus, Asporomyces, Atelosaccharomyces, Azymocandida, Azymohansenula, Azymomyces, Azymoprocandida, Babjevia, Ballistosporomyces, Basidiotrichosporon, Bensingtonia, Blastobotrysbota, Blastodlastrzo Brettanomyces (Brettanomyces bruxellensis, Brettanomyces anomalus, etc.), Bullera, Bulleromyces, Candida (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsment, Candida etchellsii, Candida etchellsment Candida intermedia, Candida krusei, Candida lactosa, Candida lipolytica, Candida mogii, Candida parapsilosis, Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc., Castellania, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, delbaryo, genus halotolerans, Debaryomyces hansenii, etc.), Debaryozyma, Dekkera, Dekkeromyces, Dematium, Dipodascus, Eeniella, Enantiothamnus, Endoblastoderma, Endoblastomyces, Endomyces, Endomycopsis, Endyllium, Etelexium, Entelex Genus, Eutorula, Eutorulopsis, Fabospora, Fellomyces, Fermentotrichon, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, Hanseniaspora, Hansenulaan, Hansenulaan, Hansenulaan, Hansenula Hansenula wickerhamii), Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Klo) eckera fluorescens, Kloeckera japonica, etc.), Kloeckeraspora, Kluyveromyces (Kluyveromyces bulgaricus, Kluyveromyces marxianus, Kluyveromyces thermotolerans, Genus Kockovaella, Kurtzmanomyces, Leucosporidium, Leucosporidium, Leucosporidium Monospora, Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycokluyveria, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora, Otosporomyces, Ogataea, Ogataea , Oosporidium genus, Pachysolen genus, Parasaccharomyces genus, Paratorulopsis genus, Parendomyces genus, Petasosospora genus, Pichia genus (genus Pichia amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia mogirum, genus Proticcpo Proteomyces, Pseudohansenula, Pseudomonilia, Pseudomycoderma, Pseudosaccharomyces , Pseudozyma spp, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae, Saccharomyces exiguus, Saccharomyces unisporus, Saccharomyces fibuligera etc.), Saccharomycodes genus, Saccharomycopsis spp, Saturnispora genus, Schizoblastosporion spp, Schizosaccharomyces spp , Schwanniomyces genus, Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus sp Genus, Vanrija, Waltomyces, Willia, Willopsis, Wingea, Xanthophyllomyces, Yamadazyma, Zendera, Zygofabospora, Zygopichia, Zygohansenula, Zygorenospora, Zygosaccharomyces, Zygosaccharomyces, etc. . Microorganisms classified as bacteria include Acetobacter genus (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadspura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. , Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellat genus ospora, Cellulomonas, Chainia, Chromobacterium, Chryseobacterium, Citrobacter, Clavibacter, Corynebacterium, Couchioplanes, Cryptosporangium, Curtobacterium, Dactylosporangium, Deinococcus, Delftia, Dermatia, Dermatia , Elytrosporangium, Enterobacter, Erwinia, Escherichia, Eubacterium, Excellospora, Exiguobacterium, Faenia, Flammeovirga, Flavobacterium, Flexibacter, Geodermatophilus, Globicatella, Gluconacetobaceto, Gluconacetobacter Genus, Gordonia, Halobacterium, Halococcus, Herbidospora, Hydrogenophilus, Hyphomicrobium, Hyphomonas, Intrasporangium, Janibacter, Jonesia, Kibdelosporangium, Kineopocusato, Kitasposatos, Kitasposatos, Kitasposatos Klebsiella, Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus dive rgens, Lactobacillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri, Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus bunchneri , Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobaci llus jugurt, Lactobacillus caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum etc.), Listonella genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum spp. Genus, Nocardioides, Nonmuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus ui, etc.), Pedobacter, Peptococcus, Peptostreptococcus, Pilimelia, Pimelobacter, Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Genus, Rathayibacter, Rhizobium, Rhizomonas, Rhodobacter, Rhodococcus, Rhodopseudomonas, Rhodospirillum, Rothia, Rubrobacter, Ruegeria, Saccharomonospora, Siracrothinas, Sporolactobacillus spp., Stenotrophomonas spp., Streptoalloteichus spp., Streptococcus spp. (Streptococcus durans, Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis , Streptococcus dysgalactiae, Streptococcus sanguis, Streptococcus acidominimus, Streptococcus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc. Genus, Thiobacillus genus, Thiomonas genus, Thiosphaera genus, Weissella genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as ascomycetes, basidiomycetes or incomplete fungi other than yeast include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria , Botryotinia, Brachybasidium, Byssochlamys, Capnodium, Ceratocystis, Ceratomyces, Chaetomium, Chrysella, Chrysocelia, Chytridium, Claviceps, Cochliobolus, Coemansia, Genus Genus, Cyttaria, Dasyspora, Derchslera, Dirchmyces, Dichomyces, Dothidea, Endogone, Entomophthora, Emericella, Eupenicillium, Eurotium, Exobasidium, Gibberella, Glomus, Graphiola, Gymnoascus, Harpella Helicomyces, Hellvella, Hemicarpenteles, Hyphochytrium, Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium , Microascus, Microstroma, Medeolaria, Melampsora, Melampsporella, Morchella, Monascus, Monilinia, Monoblephalis, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olizadium, Genus, Penicillium, Perenospora, Pestalotiopsis, Phomopsis, Phragmi
diella genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia spp. Sordaria genus, Sporidiobolus genus, Stibella genus, Stigmatomyces genus, Sydowiella genus, Talaromayces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, a sugar or ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salt, urea, uric acid, amino acids, etc. Vitamins and compounds that contain potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include density gradient separation methods such as filtration using activated carbon and filter aid, centrifugal separation, and fractional precipitation methods, density gradient sedimentation equilibrium methods, and the like.

In the present invention, as other compounds used as additives, specifically, silicic anhydride, magnesium silicate, talc, kaolin, bentonite, hectorite, natural or synthetic smectite, stevensite, mica, mica titanium, bismuth oxychloride , Zirconium oxide, Magnesium oxide, Zinc oxide, Titanium oxide, Calcium carbonate, Magnesium carbonate, Yellow iron oxide, Bengala, Black iron oxide, Gunjo, Chromium oxide, Chromium hydroxide, Carbon black, Calamine and other inorganic pigments, Peroxide Hydrogen water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxide tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate, silica Acid Inorganic reducing agents such as lithium hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide , Redox agents such as thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino-4 -Nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene hydrochloride -2,5-diamine, nitroparaphenylenedia hydrochloride Min, para-phenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5- Dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N , N′-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, Metaphenylenediamine, 5-aminoorthosulfate Resole, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, Nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine, catechol, diphenylamine, α -Dye agents such as naphthol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulphonate, hematein, musk, civet, castrium, amber Natural animal flavors such as squirrel, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon Essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western mint essential oil, dairy perfume essential oil, tuberose essential oil, clove essential oil, orange Flower essential oil, winter green essential oil, trubalsum essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peru balsam essential oil, bored rose essential oil, melamine Essential oils, Mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, vegetable flavors such as Japanese mint essential oil, other synthetic flavors, 5-amino-o-cresol , O-aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p -Phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine , 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzenesulfate sodium, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis ( β- Droxyl) -p-phenylenediamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p- Phenylenediamine sulfate, 2- (2'-hydroxyethylamino) -5-aminotoluene sulfate, 4,4'-diaminodiphenylamine sulfate, p-methylaminophenol sulfate, p-phenylenediamine sulfate, m- Phenylenediamine sulfate, toluene-2,5-diaminesulfate, 2,4-diaminophenoxyethanol hydrochloride, toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2,4-diaminophenol hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine acetate, 1,5-dihydroxynaphthalene, tolue -3,4-diamine, p-methylaminophenol, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diamino Phenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1, 4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picramate, 2-amino-5-nitrophenol sulfate, resorcinol, nitro-p-phenylenediamine sulfate, p-nitro-o-phenylenediamine sulfate Salt, p-nitro-m-phenylenediamine sulfate, Red No. 2, Red No. 3, Red No. 102, Red No. 104 (1), Red No. 105 (1), Red No. 106, Red No. 201, Red 227, Red 230 (1), Red 230 (2) Red 231, Red 232, Red 401, Red 502, Red 503, Red 504, Red 506, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2 ), Yellow 203, yellow 402, yellow 403 (1), yellow 406, yellow 407, orange 205, orange 207, orange 402, green 3, green 204, green 205, Green 401, Green 402, Brown 201, Purple 401, Blue 1, Blue 2, Blue 202, Blue 203, Blue 205, Black 401, Red cabbage dye, Red rice dye, Akane dye , Anato pigment, Ikumi pigment, Turmeric pigment, Enju pigment, Krill pigment, Amber pigment, Caramel, Gold, Silver, Gardenia pigment, Corn pigment, Onion pigment, Tamarind pigment, Spirulina pigment, Buckwheat whole pigment, Cherry pigment, Nori pigment , Hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, ruti Pigments and colorants, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower Oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, Oils and fats such as coconut oil, beef tallow, pork fat or hydrogenated products (hardened oil etc.) of these fats and oils, beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice Waxes such as wax, squalene, squalane, pristane, liquid paraffin, petroleum jelly, Mineral oils such as paraffin, ozokelide, ceresin, and microcristane wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid , Natural fatty acids such as undecylenic acid, tall oil, lanolin fatty acid, fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid, and other synthetic fatty acids , Ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and other natural alcohols, 2-hexyldecanol, isostere Alcohols such as synthetic alcohols such as ril alcohol and 2-octyldodecanol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, Hexyldecyl dimethyloctanoate, diisobutyl adipate, 2-hexyldecyl adipate, diheptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol diethylhexanoate, diethylhexane Neopentyl glycol acid, cetyl 2-ethylhexanoate, trimethylolpropane triethylhexanoate, pentaethyltetraethylhexanoate Lithritol, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, stearic acid Metal soaps such as aluminum, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, anionic surfactants (alkyl carboxylates, alkylsulfonates, alkyls Sulfate esters, alkyl phosphate esters), alkyl sulfate salts (sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, Ammonium sulfate, sodium cetyl sulfate, sodium stearyl sulfate, etc., secondary alcohol sulfate, alkyl ether sulfate (eg, polyoxyethylene lauryl sulfate triethanolamine, polyoxyethylene lauryl sodium sulfate, etc.), alkyl and alkyl allyl Ether sulfate ester salt (N-acylmethylalanine salt, N-acylglutamate, N-acylmethyltaurine, N-acyl isethionate, N-acylglycine, alkylphosphate, alkylethercarboxylate, alkylsulfone Acid salt, alkylsulfosuccinate, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether triethanolamine sulfate, polyoxyethylene lauryl ether ammonium sulfate, poly Sodium xylethylene alkyl ether sulfate, polyoxyethylene alkyl ether sulfate triethanolamine, polyoxyethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether ammonium sulfate, etc.), higher fatty acid alkylolamide sulfate, higher fatty acid ester sulfate ( Hardened coconut oil fatty acid sodium glyceryl sulfate, etc.), polyoxyethylene alkyl ether carboxylic acid, polyoxyethylene alkyl allyl ether carboxylate, sulfated oil such as sulfated castor oil, mono or dialkyl or alkenyl phosphate ester salt, polyoxy Ethylene mono- or dialkyl or alkenyl phosphate esters (sodium monolauryl phosphate, sodium isostearyl phosphate, 2-hexyldecyl phosphorus Arginine, potassium 2-heptyl undecyl phosphate, polio
Xylethylene (4-10) sodium lauryl ether phosphate, sodium monocetyl phosphate, arginine monomyristyl phosphate, sodium monooleyl phosphate, polyoxyethylene (2-10) potassium lauryl ether phosphate, sodium dioctyl phosphate, etc.), poly Phosphate ester salt of oxyethylene alkyl ether (polyoxyethylene lauryl ether phosphate, polyoxyethylene oleyl ether phosphate, polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether phosphate, polyoxyethylene alkyl ether phosphate, Polyoxyethylene alkylphenyl ether phosphoric acid, etc.), sulfonates of higher fatty acid amides or sulfonates of higher fatty acid esters (N-olefin sulfonate, N-myristoyl-N-methyl taurine) Thorium, coconut oil fatty acid methyl taurine sodium, lauroyl methyl taurine sodium, etc.), alkylbenzene sulfonate (dodecylbenzenesulfonic acid, dodecylbenzenesulfonic acid monoethanolamine, dodecylbenzenesulfonic acid diethanolamine, dodecylbenzenesulfonic acid triethanolamine, dodecylbenzene) Sodium sulfonate), sulfosuccinate (sodium diethylhexyl sulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, disodium polyoxyethylene sulfosuccinate, disodium lauryl polyoxyethylene sulfosuccinate, polyoxyethylene lauroyl ethanol sulfosuccinate Amidoester disodium, undecylenoylamidoethylsulfocha Disodium acid, sodium monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.), N-acyl sarcosine salts (sodium lauroyl sarcosine, palmitoyl sarcosine sodium, etc.), higher fatty acid and amino acid condensates (N -Acyl glutamate, sodium N-stearoyl glutamate, potassium N-palmitoyl glutamate, sodium N-lauroyl-L-glutamate, disodium N-stearoyl-L-glutamate, sodium N-myristoyl-L-glutamate, sodium myristoyl methyl taurate, Palmitoylmethyl taurine sodium, stearoyl methyl taurine sodium, N-palmitoyl-β-alanine arginine, N-palmitoyl aspartic acid Anionic surfactants such as fatty acid soaps such as triethanolamine), oleate, suarate, laurate, palmitate, etc. (examples of anionic surfactant salts include sodium salt, potassium salt, etc. Alkali metal salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, organic ammonium salts such as L-lysine salts and L-arginine salts, ammonium salts, etc.), quaternary ammonium salts (alkyltrimethyl chloride) Ammonium, cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, Stearyl dimethyl ammonium chloride, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dicetyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide, distearyl chloride Ammonium, distearylammonium bromide, dicetylmethylammonium chloride, dicetylmethylammonium bromide, dilaurylmethylammonium chloride, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearylmethylammonium bromide, cetyltrimethyl chloride Ammonium, cetyltrimethylammonium bromide, stearyltrimethylammonium chloride, stearyltrimethylbromide Ammonium, lauryltrimethylammonium bromide, dialkyldimethylammonium chloride, dicetyldimethylammonium chloride, distearyldimethylammonium chloride, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, ethyl lanolin sulfate fatty acid aminopropylethyl Dimethylammonium, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyethylmonium metasulfate, dicocoylethyl Droxyethylmonium metasulfate, dipalmitoylethylhydroxyethylmonium metasulfate and cetyltriethylammonium methyl sulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium bromide, alkylpentaethoxyammonium chloride, Ditallow dimethyl ammonium chloride, ditallow dimethyl ammonium methyl sulfate, ditallow dipropyl ammonium phosphate, ditallow dimethyl ammonium nitrate, di (coconut alkyl) dimethyl ammonium chloride, di (coconut alkyl) dimethyl ammonium bromide, coconut ammonium chloride, steal Amidopropyl chloride PG-dimonium phosphate , Stearamide propyl ethyl dimonium esosulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl dimethyl ammonium chloride, stearamide propyl dimethyl ammonium lactate , Ethyl sulfate lanolin fatty acid aminopropylethyldimethylammonium, cationized cellulose, acyldiethylaminoethylamide, acyldimethylaminopropylamide, polyoxyethylene fatty acid amide, myristyldimethylamine oxide, N-lauryldimethylaminoacetic acid betaine, N-myristyldimethylamino Betaine acetate, N-stearyldimethylaminoacetic acid betaine, etc.), bis-fatty acid ester salts (hydroxyl Pyr-bis-lauramidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristate amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-amidopropyl palmitate-N, N-dimethyl Ammonium chloride, hydroxypropyl-bis-amidopropyl stearate-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenate amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N , N-dimethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-dimethylammonium chloride , Hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-lauric acid amidoethyl-N, N- Diethylammonium chloride, hydroxypropyl-bis-myristate amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palmitamidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearamide-N, N -Diethylammonium chloride, hydroxypropyl-bis-behenic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidoethylammonium chloride, hydroxy Propyl-bis-isostearic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, Hydroxypropyl-bis-tallow fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-lauramidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristate amidopropyl-N, N-diethyl Ammonium chloride, hydroxypropyl-bis-palmitic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidopropyl stearate-N, N-diethylammonium chloride Hydroxypropyl-bis-behenic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N- Diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl- N, N-diethylammonium chloride, etc.), stearamidepropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamidepropylethyldimonium ethosulphate, steer Cationic surfactants such as ruamidopropyldimethyl (myristyl acetate) ammonium chloride, stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldimethylammonium chloride, stearamidepropyldimethylammonium lactate, glycerin fatty acid ester ( Glyceryl monoundecylenate, glyceryl diundecylenate, glyceryl monomyristate, glyceryl dimyristate, glyceryl monopalmitate, glyceryl dipalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, mono-cotton oil fatty acid glycerin, monoeruka Glyceryl acid, glyceryl sesquioleate, glyceryl monostearate, α, α'-oleic acid pyroglutamate glyceride Glyceryl monostearate), polyglyceryl fatty acid esters (diglyceryl monomyristate, diglyceryl dimyristate, diglyceryl trimyristate, diglyceryl monopalmitate, diglyceryl dipalmitate, dipalmityl tripalmitate) Glyceryl, diglyceryl monostearate, diglyceryl distearate, diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, diglyceryl trioleate, tetraglyceryl monopalmitate, tetraglyceryl dipalmitate, tripalmitin Tetraglyceryl acid, tetraglyceryl tetrapalmitate, tetraglyceryl pentapalmitate, tetraglyceryl monostearate, tetraglyceryl distearate, tristearate Tetraglyceryl phosphate, tetraglyceryl tetrastearate, tetraglyceryl pentastearate, tetraglyceryl monooleate, tetraglyceryl dioleate, tetraglyceryl trioleate, tetraglyceryl tetraoleate, tetraglyceryl pentaoleate, hexapalmitate monopalmitate Glyceryl, hexaglyceryl dipalmitate, hexaglyceryl tripalmitate, hexaglyceryl tetrapalmitate, hexaglyceryl pentapalmitate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, hexaglyceryl tetrastearate, penta Hexaglyceryl stearate, hexaglyceryl monooleate, hexaglyceryl dioleate, Hexaglyceryl oleate, tetraoleate hexaglyceryl, penta oleic hexaglyceryl monopalmitate decaglyceryl dipalmitate deca
Glyceryl, depalglyceryl tripalmitate, decaglyceryl tetrapalmitate, decaglyceryl pentapalmitate, decaglyceryl hexapalmitate, decaglyceryl heptapalmitate, decaglyceryl octapalmitate, decaglyceryl nonapalmitate, decaglyceryl decapalmitate, Decaglyceryl monostearate, decaglyceryl distearate, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, decaglyceryl octastearate, nonastearic acid Decaglyceryl, decastearate decaglyceryl, monooleate decaglyceryl, dioleate decaglyceryl, Decaglyceryl oleate, decaglyceryl tetraoleate, decaglyceryl pentaoleate, decaglyceryl hexaoleate, decaglyceryl heptaoleate, decaglyceryl octaoleate, decaglyceryl nonaoleate, decaglyceryl decaoleate, decaglyceryl monohydroxystearate Glyceryl, dehydroxyglyceryl dihydroxystearate, decaglyceryl trihydroxystearate, decaglyceryl tetrahydroxystearate, decaglyceryl pentahydroxystearate, decaglyceryl hexahydroxystearate, decaglyceryl heptahydroxystearate, decaglyceryl octahydroxystearate, Nonahydroxystearate decaglyceryl, decahydroxystearate decag (Seryl, hexaglyceryl polyricinoleate, decaglyceryl polyricinoleate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, polyoxyethylene glyceryl monooleate, polyoxyethylene glyceryl monomyristate, etc.), polyoxyethylene Glycerin fatty acid ester (polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate etc.), sorbitan fatty acid ester (sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, Sorbitan trioleate, sorbitan monopalmitate, sorbitan monostearate, sorbitan distearate, geo Sorbitan inacid, sorbitan monopalmitate, sorbitan tristearate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, polyoxyethylene sorbitan monooleate, monostearic acid Polyoxyethylene sorbitan, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate, propylene glycol fatty acid ester (propylene glycol monooctanoate, monodecane) Acid propylene glycol, monostearate propylene glycol, etc.), sucrose fatty acid ester (monolauric acid sucrose ester) Dilauric acid sucrose ester, monopalmitic acid sucrose ester, dipalmitic acid sucrose ester, monostearic acid sucrose ester, distearic acid sucrose ester, etc.), dextrin fatty acid ester (such as dextrin palmitate), palm oil fatty acid alkanol Amides, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester , Polyoxyethylene hydrogenated castor oil maleic acid, polyoxyethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, Oxyethylene behenyl ether, polyoxyethylene oleyl ether, polyoxyethylene lauryl ether, polyoxyethylene-2-octyldodecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxyethylene alkylphenyl ether (polyoxyethylene nonylphenyl ether, Polyoxyethylene octyl phenyl ether), polyoxyethylene fatty acid esters (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxy Ethylene sorbitol lanolin, etc.), POE-POP-alkyl ether (POE-POP-cetyl ether, POE-POP-2-decylteto) Decyl ether, POE-POP-monobutyl ether, POE-POP-hydrogenated lanolin, POE-POP-glycerin ether, Tetronic, etc.), alkanolamide (coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.) Nonionic surfactants such as betaine-type amphoteric surfactants (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, undecylcarboxymethoxyethylcarboxymethylimidazolinium Betaine sodium, undecyl hydroxyethyl imidazolinium betaine sodium, undecyl-N-hydroxyethyl-N-carboxymethyl imidazolinium betaine, alkyldiaminoethylglycine hydrochloride, stearyl dihydroxyethyl betaine , Stearyldimethylaminoacetic acid betaine, sodium stearyldimethylbetaine solution, coconut oil alkyl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethylaminoacetic acid betaine, coconut oil fatty acid amide Propylbetaine, palm oil fatty acid-N-carboxymethoxyethyl-N-carboxyethylimidazolinium betaine sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-cocoyl-N'-carboxymethyl -N'-hydroxyethyl ethylenediamine sodium, lauryl dimethylaminoacetic acid hydroxysulfobetaine, coconut oil alkyldimethylaminoacetic acid hydroxysulfobetaine, laurylaminopropionic acid triethanolamine , Β-laurylaminopropionate sodium, laurylamidopropyldimethylaminoacetic acid betaine, lauric acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, palm oil fatty acid amidopropyldimethylaminoacetic acid Hydroxysulfobetaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine, lauryl diaminoethylglycine sodium, Lauric acid amidopropyl betaine solution, lauryl sulfobetaine, lauryl hydroxysulfobetaine, 2-hepta Sil-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethylalphacarboxyethylbetaine, cetyldimethylcarboxymethylbetaine, cetyldimethylbetaine, laurylbis- (2- Hydroxyethyl) carboxymethyl betaine, stearyl bis- (2-hydroxypropyl) carboxymethyl betaine, oleyldimethylgamma-carboxypropyl betaine, lauryl bis- (2-hydroxypropyl) alpha-carboxyethyl betaine, cocodimethylsulfopropyl betaine, stearyl dimethyl Sulfopropylbetaine, lauryldimethylsulfoethylbetaine, laurylbis- (2-hydroxyethyl) sulfopropylbeta INV, LEBON 2000 (Sanyo Kasei Co., Ltd.), Anon BDF (Nippon Yushi Co., Ltd.), Lonzain-CS (Lonza), Miratine CBS (Milanol), Anon BL (Nippon Yushi), Lonzain 12CS (Lonza), etc.) Imidazolinium-type amphoteric surfactants (bis (stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, N-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-alkyl-N-carboxymethyl- N-hydroxyethylethylenediamine lauryl sulfate and salts thereof, coconut oil alkyl-N-carboxyethoxyethyl-N-carboxyethylimidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethylimidazolinium Disodium hydroxide, palm oil alkyl-N-carboxymethoxyethyl-N-carboxyethylimidazo Sodium disodium lauryl sulfate, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, ovazoline 662 (Toho Chemical Co., Ltd.), Swanol AM-101 (Nikko Chemicals Co., Ltd.), Anon GLM (Nippon Yushi Co., Ltd.)), aminopropionic acid type amphoteric surfactants (alkylaminopropionic acid such as sodium dodecylaminopropionate, alkylamino) Dipropionic acid, etc.), sodium dodecylaminopropanesulfonate, N-higher alkylaspartic acid or a salt thereof, coamidopropyl chlorinated polyethylene glycol dimonium phosphate, cocamidopropyl hydroxysultain, sodium lauroyl sarcosinate, alkylamine oxide ( Decylamine oxide, Amphoteric surfactants such as cocoamine oxide, myristoylamine oxide, palmitoylamine oxide, alkyldimethylamine oxide, alkylamidopropylamine oxide), natural surfactants (lecithin, sodium caseinate, sphingolipid, saponin, mannosyl polyvalent) Alcohol fatty acid esters, glucosyl polyhydric alcohol fatty acid esters, monosaccharide polyhydric alcohol fatty acid esters such as galactosyl polyhydric alcohol fatty acid esters, disaccharide polyhydric alcohol fatty acid esters, oligosaccharide polyhydric alcohol fatty acid esters, etc.) and amino acid surfactants (Capric acid chloride, lauric acid chloride, myristic acid chloride, palmitic acid chloride, stearic acid chloride, oleic acid chloride, behenic acid chloride, coconut oil fatty acid Reaction products of fatty acid chlorides such as chloride with glycine, sarcosine, β-alanine, N-methyl-β-alanine, taurine, N-methyltaurine and other broad amino acids), silicone surfactants (silicon KF-6011 ( Shin-Etsu Chemical), KF-6012 (Shin-Etsu Chemical), KF-6013 (Shin-Etsu Chemical), KF-6015 (Shin-Etsu Chemical), KF-6016 (Shin-Etsu Chemical) , KF-6017 (Shin-Etsu Chemical Co., Ltd.), X-22-4991 (Shin-Etsu Chemical Co., Ltd.), NUC Silicon L7002 (Nihon Unicar), SH-3772C (Toray Dow Corning Silicone), SH-3775C Polyoxyalkylene-modified organopolysiloxane such as Toray Dow Corning Silicone, ABIL EM-90 (Gold Schmidt), ABIL B9806 (Gold Schmitt), Silicon KF-6026 (Shin-Etsu Chemical Co., Ltd.) Long chain alkyl-containing polyoxyalkylene-modified organopolysiloxa Etc.), polyether-modified silicone (polyoxyethylenemethylpolysiloxane copolymer, poly (oxyethyleneoxypropylene) methylpolysiloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivatives , Dimethylpolysiloxane, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alcohol-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, ammonium-modified polymer silicone, organopolysiloxane, methylphenylpolysiloxane, poly Siloxane, poly (N-acylalkylenimine) modified silicone, dimethylpolysiloxane, methylphenylpolysiloxane, nitrogen-containing Acrylic silicone-based graft copolymer, decamethylcyclopentasiloxane, fluorinated alkyl-modified sheet
Ricone, organopolysiloxanylsilylalkyl-modified silicone, tricyclic diterpenecarboxylic acid-modified silicone, trifluoroalkyl-modified silicone, divinylpolydimethylsiloxane, dihydrogenopolydimethylsiloxane, dihydrogenopolydimethylsiloxane divinylpolydimethylsiloxane polymer , Trimethylsiloxysilicic acid, polyoxypropylene methylpolysiloxane copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, ethylphenylpolysiloxane, octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetra Phenyltetracyclosiloxane, polyether-modified polysiloxane, amino-modified polysiloxane, epoxy-modified polysiloxane , Fluorine-modified polysiloxane, alcohol-modified polysiloxane, alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laurylmethicone copolyol, aminoethylaminopropylsiloxane dimethylsiloxane copolymer, eugenol-modified silicone and other silicone compounds, Selenium sulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, quinine hydrochloride, strong ammonia water and other hair treatment agents, zein, shellac, carboxymethylcellulose or alkali metal salts thereof, hydroxypropylcellulose or phthalated derivatives thereof And succinylated derivatives, hydroxypropyl cellulose acetate or phthalated derivatives and succinylated derivatives thereof, acrylic acid compounds-methacrylic acid compounds Film-forming agents such as copolymers.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

Production of levan by fermentative production using Rhonera aquatilis 50 ml of pre-culture medium (3.0 w / v% sugar, 0.1 w / v% dipotassium phosphate, 0.05 w) / v% magnesium sulfate heptahydrate, 0.001w / v% iron sulfate heptahydrate, 0.3w / v% sodium nitrate, 0.05w / v% potassium chloride, 0.01w / v yeast extract, pH 8.0) 1 Platinum ear was inoculated and cultured with shaking at 25 ° C. and 160 rpm for 48 hours. Next, 5 mL of the culture solution was added to 500 mL of the main culture medium (the medium composition and pH were the same as the preculture medium), and shaking culture was performed at 25 ° C. and 160 rpm for 120 hours. Next, the whole culture broth was collected and heated at 90 ° C. for 1 hour, then acid was added to adjust to pH 3.0, and the mixture was allowed to stand at 20 to 25 ° C. for 48 hours. Next, the culture solution is filtered in the order of filter paper, φ0.65 μm membrane filter, and φ0.45 μm membrane filter, and ethanol with a volume of 65 v / v% final concentration is added to the filtrate with stirring to form a precipitate. I let you. Next, the precipitate was collected, washed with ethanol added again, and then freeze-dried and pulverized to obtain a powdery levan (yield 40%) as the title substance.

Manufacture of levan by fermentation production using Microbacterium sp. Seeds 50 ml of pre-culture medium (3.0 (w / v)% sugar, 0.1 (w / v)% phosphorus) Dipotassium acid, 0.05 (w / v)% magnesium sulfate heptahydrate, 0.001 (w / v)% iron sulfate heptahydrate, 0.3 (w / v)% sodium nitrate, 0.05 (w / v)% chloride One platinum loop was inoculated into potassium, 0.01 (w / v) yeast extract, pH 6.0) and cultured with shaking at 25 ° C. and 160 rpm for 48 hours. Next, 5 mL of the culture solution was added to 500 mL of the main culture medium (the medium composition and pH were the same as the preculture medium), and shaking culture was performed at 25 ° C. and 160 rpm for 120 hours. Next, the whole culture broth was collected and heated at 90 ° C. for 1 hour, then acid was added to adjust to pH 3.0, and the mixture was allowed to stand at 20 to 25 ° C. for 48 hours. Next, the culture solution is filtered in the order of filter paper, φ0.65 μm membrane filter, and φ0.45 μm membrane filter, and ethanol with a volume of 65 v / v% final concentration is added to the filtrate with stirring to form a precipitate. I let you. Next, the precipitate was recovered, washed again by adding ethanol, and then freeze-dried and pulverized to obtain a powdery levan (yield 0.17%) as the title substance.

Whitening effect test using melanin production inhibitory action as an index In this test, melanin production inhibitory action was tested as an index of whitening action. As a sample to be used for this test, each levan of Examples 1 and 2, levan derived from Serratia lebanicam (manufactured by Wako Pure Chemical Industries, Ltd.), and 0.5 (w) of arbutin whose whitening effect has been confirmed as a positive control. / v)% aqueous solution and purified water as negative control. B16 mouse melanoma cells 3 × 10 ⁴ cells were pre-cultured in 5% FBS-MEM liquid medium (60 mm petri dish) at 37 ° C. under 5% CO ₂ for 24 hours, and then the medium was removed. Then the B16 melanoma cells pre-cultured, 5% FBS-MEM liquid medium and containing density to a medium total amount to adding the sample amount of the 50μg / mL, 37 ℃, 5 % CO 2 under 72 hours ago Cultured. Next, the medium was removed, and the cells were collected using a Tripsin / EDTA solution. The collected cells were dissolved in 1N NaOH solution containing 10% DMSO to extract melanin in the cells. The absorbance of the obtained melanin extract at a wavelength of 420 nm was measured, and the obtained numerical value was defined as the melanin production amount in this test. The results are shown in FIG.

Results of whitening test using melanin production inhibitory function as an index As a result of testing the melanin production inhibitory action of each test sample, as shown in FIG. 1, compared with purified water as a negative control and arbutin as a positive control. In Examples 1 and 2 and the system to which levan derived from Serratia levanicum was added, a low absorbance value was obtained, indicating a low production amount of melanin. Therefore, it has been found that levan used in the present invention has a melanin production inhibitory action and a whitening action based on the action.

Whitening test using tyrosinase activity inhibitory action as an index In this test, tyrosinase activity inhibitory action was tested as an index of whitening action. As a sample to be used in this test, 0.5% (w / v) aqueous solution of arbutin, which has been confirmed to be whitening as a positive control, and purified water as a negative control were used. B16 mouse melanoma cells 4 × 10 ⁴ cells were cultured in 5% FBS / theophylline-containing MEM liquid medium (60 mm petri dish) at 37 ° C. under 5% CO ₂ for 72 hours. After removal of the medium, a Tripsin / EDTA solution was used. Cells were harvested. Next, the collected cells are suspended in 100 mM phosphate buffer (KH ₂ PO ₄ / K ₂ HPO ₄ , pH 7.2) containing 1.0% polyoxyethylene (9) octylphenyl ester, and 1 × 10 ⁶ cells / mL. I adjusted it. Next, after the cells in the suspension were monogenized, the water-soluble fraction was collected and used as a crude enzyme solution. Next, mix 50 μL of the obtained crude enzyme solution, 50 μL of the test sample, 50 μL of 0.05 (w / v)% L-Dopa and 50 μL of 100 mM phosphate buffer (KH ₂ PO ₄ / K ₂ HPO ₄ , pH 7.2). Then, after standing at 37 ° C. for 2 hours, the absorbance of the mixed solution at a wavelength of 420 nm was measured, and the obtained value was defined as the melanin production amount in this test. The results are shown in FIG.

Results of whitening effect test using tyrosinase activity inhibitory action as an index As a result of testing tyrosinase activity inhibitory action of each test sample, as shown in FIG. 2, Examples 1-2 were compared with purified water as a negative control. A low absorbance value was obtained in the system to which the levan was added, indicating a low melanin production amount. In particular, the Levan derived from Ronella Aquatilis which is Example 1 showed no absorption at a wavelength of 420 nm. Since this test targets the reaction between tyrosinase present in the crude enzyme and the substrate L-dopa, levan used in the present invention has a tyrosinase activity inhibitory action and a whitening action based on that action. It has been found.

Whitening test using pigmentation inhibitory action as an index In this test, pigmentation inhibitory action was tested as an index of whitening action. As samples to be used in this test, each levan of Examples 1 and 2, arbutin 3.0 (w / v)% aqueous solution as a positive control, and purified water as a negative control were used. The back skin hairs of test animals (6 week old WM female guinea pigs, 5 per group) were shaved and allowed to stand for a while. Next, a shading backing paper was applied to the shaved back skin, and UV-B (250 mJ / cm ² , FL20S / E40 lamp manufactured by Toshiba Corporation) was irradiated for 5 minutes at 4 locations in a 2 × 2 cm section. The same operation was repeated for 3 days. From the next day (the third day after the start of the test), 20 μL of each sample was applied to each compartment that had been irradiated with ultraviolet rays so that one specimen was used for each compartment, and the same operation was repeated once a day. The color difference meter (Minolta Color) was used to measure the brightness (hereinafter referred to as L value) of each section on the 3rd, 4th, 5th, 7th, 8th, 10th and 15th days of the start of the test. Measurement was performed using a color difference meter CR-200). Then, the difference (ΔL value) between each measured value and the L value at the same site before the start of the test was calculated. It can be said that the greater the ΔL value, the more the pigmentation progressed. The results are shown in FIG.

Results of whitening effect test using pigmentation inhibitory action as an index As a result of examining the pigmentation inhibitory action of each test sample, as shown in FIG. 3, Examples 1-2 were compared with purified water as a negative control. In the system to which is applied, increase in ΔL value was suppressed, and as a result, pigmentation was suppressed. In the system to which Example 2 was applied, the ΔL value was equivalent to that of the negative control before and after the final day of the test, and the pigmentation inhibitory action was low. In particular, the system to which Example 1 was applied was equivalent to the positive control. Showed an inhibitory effect on pigmentation. Accordingly, it has been found that levan used in the present invention has a pigmentation-inhibiting action and a whitening action based on the action.

(Production Example) Production of Various Cosmetic Compositions Production examples of various cosmetic compositions containing the whitening agent of the present invention are shown below, but the present invention is not limited thereto.

(Production Example 1) Milk mass%
Levan 4.5
Squalane 5.0
Olive oil 5.0
Jojoba oil 5.0
Cetyl alcohol 1.5
Glycerol monostearate 2.0
Polyoxyethylene (20) cetyl ether 3.0
Polyoxyethylene (20) soorbitan monooleate 2.0
P-Hydroxybenzoate ester
Residue with 100 purified water

(Production Example 2) Lotion Toner Mass%
Levan 1.5
Sodium glutamate 1.0
1,3-butylene glycol 3.0
Glycerin 2.5
Polyethylene glycol 400 3.0
Olive oil 0.5
Polyoxyethylene (20)
Sorbitan monostearate ester 1.5
Polyoxyethylene (5) oleyl alcohol ether 0.3
Ethanol 10.0
Perfume Appropriate amount Dye Appropriate amount Phenoxyethanol 0.1
Citric acid 1.0
Sodium citrate 1.2
Residue with 100 purified water

(Production Example 3) Lotion Mass%
Leban 5.5
Glycerin 2.0
1,3-butylene glycol 3.5
Ethanol 15.0
Iron oxide 0.2
Zinc oxide 0.5
Kaolin 2.0
Trehalose 2.0
Dextrin 0.5
Preservative Appropriate amount Fragrance Appropriate amount
Residue with 100 purified water

(Production Example 4) Lotion Mass%
Leban 3.2
Sodium citrate 1.0
Dipropylene glycol 5.0
Raffinose 1.0
Ethanol 5.0
Phenoxyethanol 0.2
Pectin 0.01
Xanthan gum 0.05
Acetylglucosamine 0.05
Diisopropylamine dichloroacetic acid 0.2
Allantoin 0.2
N-menthyl glyceryl ether 0.2
Dipotassium glycyrrhizinate 0.2
Perfume
Residue with 100 purified water

(Production Example 5) Cream mass%
Leban 4.6
Stearic acid 2.0
Glycerol monostearate2.0
Cetanol 3.0
Cholesterol 0.5
Vaseline 2.0
Squalane 10.0
Liquid paraffin 10.0
Dimethylpolysiloxane 1.0
Sodium glutamate 2.0
Glycerin 5.0
Dipropylene glycol 3.0
Nicotinamide 1.0
Methyl paraoxybenzoate 0.1
Butyl paraoxybenzoate 0.1
Perfume
Residue with 100 purified water

(Production Example 6) Face wash mass%
Leban 2.4
Sodium aspartate 1.0
Methoxycinnamic acid 1.0
Myristic acid 25.0
Stearic acid 5.0
Tallow fatty acid 5.0
Propylene glycol 10.0
Potassium hydroxide 6.0
Palm oil fatty acid diethanolamide 6.0
Glycerol 1.0
1,3-butylene glycol 1.0
Dipotassium glycyrrhetinate 1.0
Preservative 0.1
Perfume
Residue with 100 purified water

(Production Example 7) Body soap mass%
Leban 2.0
Sodium citrate 2.0
N-acetylglutamic acid 1.0
Potassium laurate 15.0
Potassium myristate 5.0
Propylene glycol 5.0
Sorbitol 3.0
Disintegrating cellulose granules 0.5
Hydroxypropyl chitosan solution 0.5
Preservative appropriate amount
pH adjuster appropriate amount perfume appropriate amount
Residue with 100 purified water

(Production Example 8) Powder foundation mass%
Levan powder 3.0
Silicone-treated mica 25.0
Sericite 17.0
Hydrophobic treated silica 20.0
Titanium oxide 20.0
Spherical alumina powder 4.0
Dimethylpolysiloxane 4.0
Methylphenylpolysiloxane 1.0
Vaseline 3.0
Octyl methoxycinnamate 3.0
Sorbitan diisostearate 1.0
Antioxidant Appropriate perfume Appropriate paraoxybenzoic acid
Remaining as talc 100

(Production Example 9) Emulsified liquid foundation mass%
Leban 1.0
Sodium glutamate 1.5
Octamethylcyclotetrasiloxane 20.0
Polyoxyethylene (6) oleyl ether 4.0
Polyoxyethylene hydrogenated castor oil 3.0
Aluminum monostearate 0.01
Liquid paraffin 12.0
Dimethylpolysiloxane 5.0
12-hydroxystearic acid 1.0
Nylon powder 4.5
Black iron oxide 1.5
Yellow iron oxide 3.0
Titanium oxide 5.0
Red iron oxide 2.0
Butyl paraoxybenzoate 0.2
Sorbitol 7.0
Residue with 100 purified water

(Production Example 10) Bath agent mass%
Leban 5.5
Sodium bicarbonate 60.0
Borax 5.0
Sodium hyaluronate 1.0
Hydroxypropyl methylcellulose 1.0
Karin extract 5.0
Antibacterial agent appropriate amount perfume appropriate amount
Residual sodium sulfate 100

(Production Example 11) Ointment Mass%
Levan 4.0
l-Menthol 3.0
DL-Camphor 0.5
Propylene glycol 15.0
Carboxyvinyl polymer 1.0
Hydroxyethyl cellulose 0.1
Lauro Macrogol 1.5
Triethanolamine 0.7
Purified water 25.0
Ethanol 100 residue

(Production Example 12) Patch mass%
Levan 3.5
l-Menthol 3.0
DL-Camphor 1.5
Polyacrylic acid 4.5
Sodium polyacrylate 1.5
Sodium carboxymethylcellulose 4.0
Glycerol 20.0
Sorbitol 5.0
Polyoxyethylene nonylphenyl ether 0.5
Kaolin 5.0
Castor oil 1.0
The residue obtained by dissolving, dispersing and kneading the remaining components as purified water 100 was spread on a polyester non-woven fabric so as to be 800 g per 1 m ² to produce a patch.

(Manufacture example 13) Coating preparation A gauze or liniment cloth is impregnated with an equal amount of 1.0% levan aqueous solution and mixed with a moisturizing agent, anti-inflammatory agent, cell activator, antioxidant, etc. and attached to the wound. To do. Further, an application method in which these are directly applied locally and coated with gauze or the like may be adopted.

It is a figure which shows the melanin production inhibitory effect of a levan. It is a figure which shows the tyrosinase activity inhibitory effect of a levan. It is a figure which shows the pigmentation inhibitory effect of levan.

Claims (4)

  A whitening agent characterized by containing levan.   The whitening agent according to claim 1, which is a melanin production inhibitor.   The whitening agent according to claim 1, which is a tyrosinase activity inhibitor. The whitening agent according to claim 1, which is a pigmentation inhibitor.

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