JP2010013400A - Melanin formation inhibitor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a bleaching agent and a cosmetic for bleaching, having melanin formation-inhibiting effects, and containing a highly safe plant extract stable in formulation. <P>SOLUTION: The melanin formation inhibitor, the bleaching agent, the cosmetic composition and the cosmetic for the bleaching, suppressing the formation of melanin pigment, having bleaching effects, reducing blotches and freckles on the skin, ameliorating dry skin and imparting gloss and tenseness to the skin contain an extract of one or more kinds of plants selected from Inula racemosa and Andrographis paniculata. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a melanin production inhibitor containing one or more plant extracts selected from Inura racemosa and sensinren as an active ingredient, and a whitening agent containing a melanin production inhibitor, or a cosmetic composition and a whitening cosmetic. is there.

  Factors that determine human skin color include the amount of melanin in the epidermis, blood flow in capillaries, food-derived pigment (carotene), and the thickness of the stratum corneum. Among these, the most important factors are One is melanin pigment. The so-called liver spots (spots), sparrow eggs (sobacus), and skin pigmentation after sunburn are markedly enhanced production of melanin pigments due to the activation of pigment cells in the skin. It has become one of the major skin problems for women.

  This melanin pigment is produced in melanosomes, which are organelles in pigment cells (melanocytes) present in the basal layer of the epidermis, the hair root, and the outer root sheath. In the process of melanin pigment production, tyrosinase acts on tyrosine in pigment cells (melanocytes) to oxidize tyrosine, convert it into dopa and dopaquinone, and further auto-oxidize to produce dopachrome and 5,6-dihydroxyindole. After that, it polymerizes and eventually becomes a melanin pigment. The produced melanin is secreted from the dendrites of pigment cells (melanocytes) to the basal cells, and the basal cells divide and become spiny cells, then rises, reaches the stratum corneum, and then drops off with detachment of the stratum corneum. It is supposed to go.

  Therefore, in order to prevent or improve skin spots (spots), sparrow eggspot (sobacus) and darkness, inhibit the melanin production process. Alternatively, it is conceivable to lighten already produced melanin. Therefore, various whitening components have been proposed based on these ideas. For example, kojic acid and its derivatives, ascorbic acid and its derivatives, tocopherol and its derivatives, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract and plant extract (Arnica, Altea , Aloe, Ogon, Enmezo, Chamomile, Licorice, Gardenia, Gennosho, Sikon, Shouma, Birch, Senkyu, Genoko, Psycho, Wildflower, Toki, Tokisenka, Elderberry, Safflower, Garlic, Syringe, Logwood) Are known.

  Therefore, in order to prevent or improve skin spots (spots), sparrow eggspot (sobacus) and darkness, inhibit the melanin production process. Alternatively, it is conceivable to lighten already produced melanin. Therefore, various whitening components have been proposed based on these ideas. For example, an azulene compound such as azulene, guaiazulene and sodium guaiazulene sulfonate, kojic acid or a derivative thereof, ascorbic acid or a derivative thereof, hydroquinone or a derivative thereof, placental extract, and liquiritin are used as an external preparation for inhibiting melanin production (Patent Literature) 1). Also, use a solvent extract of Rosaceae Pyracantha plant and / or a solvent extract of Saxifraga stolonifera as a cosmetic composition for whitening (see Patent Document 2). In addition, it is known that a whitening cosmetic is made from an extract of a Japanese knotweed, a honey beetle, or a bluebird (see Patent Document 3).

JP-A-5-310562 JP-A-5-58870 JP-A-5-294819

  However, the above-mentioned whitening component is poor in stability and solubility in the formulation system, has an odor and coloring due to starch and decomposition, is not sufficiently effective at the living body level, and causes skin irritation, etc. There was a problem in terms of safety and it was not satisfactory.

  In view of such circumstances, the present inventors set the theme of development of plants that are not natural but useful in nature, have a melanin production inhibitory effect, are highly safe, and are also stable in formulation. Eagerly investigated.

  As a result, it was confirmed that one or more plant extracts selected from Inuraracemososa and Sensinren significantly reduced the production of melanin pigments and had a whitening effect, further reduced skin spots and freckles, The present invention has been completed by providing a highly safe melanin production inhibitor or whitening agent that can improve and give gloss and tension to the skin, as well as a cosmetic composition and a whitening cosmetic.

  The “inula racemosa” used in the present invention is a plant belonging to the family Compositae, Inula race: Inula racemosa whole plant, flower, fruit, stem or leaf, branch leaf, rhizome, root bark, Use roots.

  In addition, the term “sensinren: centripetal lotus” used in the present invention refers to plants of Acanthaceae and Andrographis: whole plants, flowers, fruits, stems or leaves, branch leaves, rhizomes of the genus Andrographis paniculata. , Root bark, roots, etc. are used.

  The extract of Inuraracemossa and sensinren used in the present invention refers to various parts (whole plant, flower, fruit, stem or leaf, branch and leaf, rhizome, root bark, root, etc.) of each plant as it is or after pulverization and extraction. What you did. Alternatively, it is extracted as it is or after pulverization with a solvent.

  Examples of the extraction solvent include water, alcohols (for example, lower alcohols such as methanol, absolute ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, diethyl ether and dioxane. , Esters such as acetonitrile and ethyl acetate, and organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more kinds, and each solvent extract can be used in combination. Can be used even in

  In addition to hydrolytic extraction of each plant described above by enzymatic decomposition, those obtained by hydrolysis with acid / alkali can also be used.

The production method is not particularly limited, but is usually within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or ion exchange resin is used for adsorption, decolorization, and purification. A solution, paste, gel, or powder may be used. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decoloration may be added as long as the effect is not affected. An activated carbon column or the like may be used, and usual means generally applied depending on the extracted substance may be arbitrarily selected. In addition, an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, or any mixed solution thereof can be added to the extracted liquid after extraction. Although the obtained extract can be used as it is, it can be concentrated and dried to be used as a paste or powder.

  Inuraracemososa and sensinren plant extracts can be prepared by drying, concentrating, or diluting them according to various dosage forms and forms of melanin production inhibitors, whitening agents, cosmetic compositions, and whitening cosmetics. good.

  The inulalacemosa and sensinren extract of the present invention can be used as they are as melanin production inhibitors, whitening agents, cosmetic compositions, and whitening cosmetics, but their contents are not particularly defined, and melanin production Slightly different depending on the type, quality, and expected level of action of the inhibitor, whitening agent, cosmetic composition, and whitening cosmetic, and usually 0,001% by weight or more (hereinafter, expressed in weight%), preferably Is preferably 0.2 to 20%. If the content is less than 0.001%, the effect cannot be expected sufficiently.

  The dosage form and form of the melanin production inhibitor or whitening agent, cosmetic composition, and whitening cosmetic of the present invention are arbitrary, and capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams, It can mix | blend and use in forms, such as ointment and a sheet | seat.

  The field of use can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (for example, lotion, milky lotion) , Basic cosmetics such as cream, ointment, lotion, oil, pack, facial cleanser and skin cleanser, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after shave lotion, pre-show lotion, Makeup cosmetics such as shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail preparation, nail enamel, nail enamel Leavening agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, hairs) Treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plaster agents, tape agents, sheet agents, patch agents, aerosol agents, etc.), 5) bath water 6) Others, anti-odor and deodorant, deodorant, antiperspirant, hygiene products, sanitary cotton, wet tissue, toothpaste, mouth freshener, gargle, dishwashing agent Etc. It can also be used for general foods and drinks.

  The addition method to the melanin production inhibitor, the whitening agent, the cosmetic composition, and the whitening cosmetic of the present invention may be added in advance or may be added during the production. Just choose.

  The melanin production inhibitor, the whitening agent, the cosmetic composition, and the whitening cosmetic of the present invention are exemplified below within a range that does not impair the effects of the present invention, if necessary, in addition to the above essential components. Ingredients and additives can be selected and used in combination, and can be added with various functions. The content in the preparation is not particularly limited, but a concentration range of usually 0.0001 to 50% is preferable.

Pigmentation Inhibitor A pigmentation inhibitor can be added to the present invention. Specific examples of pigmentation inhibitors include p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof, and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acids Derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazole) -4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor Derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprosthelic acid) Phosphorus phosphate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L -Ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbine Acid sulfate ester calcium salt, L-ascorbate sulfate aluminum salt, L-ascorbate sodium salt, L-ascorbate potassium salt, L-ascorbate magnesium salt, L-ascorbate calcium salt, L-ascorbate aluminum salt, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid Phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphoric acid Ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid phosphate Tellurium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid Phosphate monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D- Galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol Ester, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid -L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid- L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L -Ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid , 2-o-α-D- Lutotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5, 6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbine Acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cina Pate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α- Coferol-2-L-ascorbic acid phosphoric diester, ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), tocopherol or its Salts and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol Acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucosi DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl Glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-toco Ferryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β- Tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- ( Sulfoethylamino) -3- (α-toco Eleyl-6-Iroxy) propan-2-ol, 1- (Carboxypropylamino) -3- (α-tocopheryl-6-Iroxy) propan-2-ol hydrochloride, S- [3- (α-Toco Ferroyl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof And derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol Orotate), kojic acid or its derivatives (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl-5 -Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid Glucose, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate , Kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or a salt thereof and derivatives thereof Baicalein or a salt thereof and derivatives thereof, berberine or a salt thereof and derivatives thereof, chrysin or a salt thereof and derivatives thereof, apigenin or a salt thereof and derivatives thereof, luteolin or a salt thereof and derivatives thereof, acetetine or a salt thereof and Derivatives thereof, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and derivatives thereof, quercetin or a salt thereof and derivatives thereof Quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and derivatives thereof, myricetin or a salt thereof And derivatives thereof, myristitrin or a salt thereof and derivatives thereof, dachiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or a salt thereof and derivatives thereof, pinocembrin or a salt thereof and derivatives thereof Naringenin or a salt thereof and derivatives thereof, hesperetin or a salt thereof and derivatives thereof, eriodictyol or a salt thereof and derivatives thereof, pinobankin or a salt thereof and derivatives thereof, aromadendrin or a salt thereof and derivatives thereof, Engeritin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof and derivatives thereof, Spira Oside, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosyl puerarin-4'-o-glucoside, 6-o-glucosyl puerarin, 3 '-Hydroxypuerarin-4'-o-glucoside,6-o-apiosyl-3'-hydroxypuerarin, etc.), γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) -glucoside, maltol -3-o- (6′-o-apiosyl) -glucoside etc.), isononyl ferrate, ellagic acid or its salts and derivatives thereof (5,4-dimethylellagic acid, 3,3′-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, Onji saponin, bacmond saponin, ruscogenin, sericoside, asiaticoside Hederin, senegin, benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) ) Benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide , 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyralin, cyproheptadine, triprolysine, dimethindene, ozagrel, isothipentyl, iproheptin, homochlorcyclidine, alimemazine, Bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, fetus (Bovine-derived, porcine-derived, horse-derived, sheep-derived, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, okera extract, kofuyou extract, uncaria extract, gaija extract, kako Juyou Extract, Licorice Extract, Gardenia Extract, Kranigean Extract, Clara Extract, Koganebana (Ogon) Extract, Wheat (Wheat) Extract, Rice (Rice) Extract, Korealia Extract, Sidwaya Extract, Sunku Kyu Extract, San Vitro Extract, Sunpens Extract, Silane (Biac Kyu) Extract, Senkyu (River Cucumber) Extract, Senna Extract, Sempukuka Extract, Senktsusai Extract, Surigatin Extract, Nodake (Pre-Human) Extract, Barley (Yokuinin) Extract, Vulture Extract, Honey beetle , Hamamelis extract, palm extract, parietalia extract, safflower (safflower) extract, mugwort (mulberry bark) extract, malvanojadine (bitter) extract, purple squirrel extract, white squirrel extract, mugwort extract, yashajitsu extract, hongkong Examples include an extract, a bitter berry extract, a quail extract, a sorghum extract, and a scorpion extract.

Humectant in the present invention may contain a humectant. Specific examples of moisturizers include gum arabic, benzoin rubber, danmar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quince seed, agar or its derivatives, casein, glucose, galactose, mannose, xylose, fructose, maltose, iso Maltose, cellobiose, gentiobiose, trehalose, cordierbiose, laminaribiose, nigerose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythrono Lactone, micalose, cladinose, accessose, alkanose, olivomai course, chromose, ebamise, vinerose , Sugars such as nogarose, bilenose, nobiose, moenuronic acid, galosamine, cybirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldgarose, blastminosin 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, mannitol and Sorbitol, ethanediol, diethylene glycol, triethylene glycol, 2-amino-2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2-butyl Diol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol, 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1, 2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, Ribitol, galactitol, lactitol, maltitol, inositol, panthenol, laminitol, valienamine, validamine, validatitol, trehalose Is a derivative thereof, D-mannosamine and derivatives thereof, isomaltoligosaccharide (panose), primeverose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene (C2-C4) oxide such as ethylene oxide Is added hydroxyalkyl (C2-C4) chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or Its salt, β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxy Polyalkylene oxides such as chill cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide or cross-linking polymerization thereof. Water-soluble polymers such as carboxyvinyl polymer, polyethyleneimine, dermatan sulfate, keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid ester, glycerin fatty acid acetyl amino acid ester, pyrrolidone carboxylic acid or salt thereof, polyaspartic acid or salt thereof , Polyglutamic acid or its salt, polylysine or its salt, sodium lactate, hydantoin and its derivatives Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxy Propyl acrylate, mannosyloxyethyl methacrylate, glutamyl lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glucurono Pyranosyl] -sophoradiol, 3-o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D- Glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [ α-L-rhamnopyranosyl-β-D-glucopyra Sil-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D- Glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol , Maruba morning glory extract, morning glory extract, athira (shokuyo kanna) extract, oilseed rape extract, amachazul extract, amana extract, sunflower extract, hagateto extract, scallop extract, garlic extract, sugimorige Ito extract, Hosoa Otome extract, Aogateto extract, Haribiyu extract, Aozulan extract, Amaranthus hippocondri Cus extract, Aristolomeria (Yurizuisen) extract, Arcana (alcanna) extract, Argarobo (cabbe) extract, Aloe vera extract, rush (1) , Dog mint extract, sardine tobacco (Iwabuchi) extract, iwahiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena thrips extract, euglena extract, unyadegato (uncaria) extract, enokitake (榎 茸) extract, eringi extract, pre-lotus eringi extract, ogatahouken extract, oguruma (civil engineering incense) extract, euglena (cereal essence) extract, oka extract, okazeli (serpentine) extract, okra extract, onidokoro extract, Tokoroe Kiss, Nagadokoro (Hikai) extract, Ononis extract, Yuuko extract, Oyster extract, Ginseng extract, Gaku hydrangea extract, Cascara sagrada extract, Gypsophila extract, Panax ginseng extract, Kaniwa extract, Carnation extract, Gerbera extract, Camcam (camo duck) ) Extract, Color extract, Oat extract, Karin (Kiso) extract, Kawara Psycho (compulsed rape, tranquilized white grass) extract, Kawajisha extract, Kawaranadeshiko (stone bamboo) extract, Ezokawaranadeko (Soba, buckwheat) extract, Kantarasaasa extract, Kikutaniku extract, quinoa extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow, teyanagi) extract, Kirangsou (golden grass essence) extract, guayule extract, Kusagisu Kazura (Tenmon winter) extract, Kuzu (Kuzu ) Extract, ginseng (yellow flower bud) extract, cupuasu extract, gumbai tuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) extract, gekkavidin (Beautiful under the moon) extract, Kouren (Huo Ren) extract, coconut extract, cosmos extract, co Button leopard extract, rice oil extract, konjac extract, saffron (banban flower, west red flower) extract, sapodilla extract, sangre degrad (croton) extract, sanchinin ginseng (37 ginseng) extract, shea (carite) extract, cyanoki extract, shiitake mushroom extract Shiitake extract, shimeji mushroom extract, hin-shimeji mushroom extract, shaka shimeji mushroom extract, hatake shimeji mushroom extract, oshiroi shimeji mushroom extract, beech shimeji mushroom extract, honji mushi extract, shirotamogitake extract, shimokren extract , Ryukyu Kasamisou Extract, Ryukyu Hydrangea (Tsunayama) Extract, White Rooster Butterfly Extract, White Clover (Chicken Bones) Extract, Ginkgo biloba (Mizuka, Ryoka Flower, Shencho Flower) Extract, Watermelon (Sairan) Extract, Suzu-Psycho (Xulongan) Extract, Surihiyu (Horse Soap, Horse Teeth) Extract, Sekkoku Extract, Sakura Sekkoku Extract, Koki Sekkoku Extract, Obanase Sekkok Extract, Okinawa Sekkok Extract, Hon Sekkokoku Extract, Shika Sekkokoku Extract, Kiba Nano Sekkok Extract, Cedron (Boushuboku) extract, mallow extract, celery extract, radish (radish) extract, takasaburo (bamboo lotus) extract, tachidokoro (hikai) extract, dahlia (tenjiku button) extract, tarwi extract, scented beetle extract, jujube extract, chankapiedra ( Nigeria citrus extract, tulip extract, chorogi extract, tsukuritake (mushroom) extract, camellia extract, camellia extract, corn beetle extract, corn extract, corn hair extract, cricket Extract, ash (skin) extract, Turkish Kyodo extract, jujube extract, vertical blade (sword bean) extract, jujube (large cocoon) extract, navena (continuous) extract, sea cucumber extract, namban ramie (seed) extract, iois violet extract, Nutzuku extract, Nemum extract, Nebu extract, Nebi extract, Nemurioki extract, Digokubana (community) extract, Nogateto extract, Hylindough extract, Hauchiwa extract, Hauchi bean extract, Papaya extract, Pahalobobo extract, Balata rubber extract, Haratake extract, White oharatake Kiss, Usukimorinokasa extract, Haran extract, Pariurus (Amanita spp.) Extract, Balsamina (Spirea, bitter gourd) extract, Harindou extract, Handaikai (胖大海) extract, Hygurmadori extract, Beet extract, Hiba extract, Sunflower extract, Pepper extract, Japanese apricot extract・ Kokia (earth silkworm) extract, spinach (Akansen, Acute pupa, peony grass) extract, Futamata kobe extract, Hosobakirinso (Keitenzochi) extract, Jojoba extract, Borage (Rurichisha) Ex , Bordeaux extract, Hononiku (meat juju, large art) extract, Honsecek (iron crust stone, sparrow mountain stone cocoon) extract, maca extract, macadamia nut extract, margaret (mokushungiku) extract, tamanozenhalen extract, kyukonkinrenka extract, Matatabi extract ) Extract, green mint extract, wheat straw extract, munya extract, murasakiki kibu extract, blue mussel kibu extract , Palm extract, Yabu tobacco (crane candy, Tenmeisei) extract, Maronie extract, mokka extract, lily extract, Ligan (Raimaru) extract, lime extract, rye extract, rakkyo extract, shallot extract, apple extract, gentian extract, Ganoderma (Wicking, Toothpick Nucleus) Extract, Astragalus Extract, Yokuinin Extract, Mini Sasanishiki Extract, Chlorella Bulgaris Extract, Chlorella Pyrenoid Extract, Chlorella Ellipsoidia Extract, Macrocystis pirifera Extract, Yuikiri Extract, Tosakanori Extract, Cypress extract, maca extract, sea squirrel extract, kawanori extract, marimo extract, mochikihito extract, ezoyahaz extract, havanori extract, yellow banyan extract, cotton bud extract, eel extract, sujime extract Lorocomb extract, Antokume extract, Tsuruarame extract, Kuroshiome extract, Nekoshikonbu extract, Ainu turtle extract, Chigaiso extract, Ezoi Shige extract, Yabanemoku extract, Trumpet extract, Uganomok extract, Joromoku extract, Hiemoku extract, Tamanashimoku extract, Honda walla extract, Sugi Moku Extract, Bovine Kenori Extract, Susabi Nori Extract, Akebono Mozuku Extract, Cypridina Extract, Fusanori Extract, Hosobanamino Hana Extract, Hanafunoori Extract, Itofonori Extract, Kaginori Extract, Mirin Extract, Hosobamirin Extract, Kikutosaka Extract, Ibarameshi Extract, Ibaranoshi Extract , Kagii Baranori Extract, Saidaibara Extract, Tatyibara Extract, Ogonori Extract, Tsurushiramo Extract, Hachijogusamodoki Kiss, Okitsunori extract, Aqaba ginkgo Saw extract, natto culture metabolites, natto extract, sponge gourd water, birch (birch) or Akamatsu sap, and the like.

Cell activating agent / metabolic activator A cell activating agent / metabolic activator can be added to the present invention. Specific examples of cell activators and metabolic activators include vitamin A group: retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidate, etc.) ), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analog (4-[[[8- (3,5-dimethylphenyl ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl) ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3,4- Dimethylphenyl) -2-naphthaleni ] Carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-isopropylphenyl) -2 -Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-fluorophenyl) -2 -Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl-2-naphthalenyl) carbonyl] Amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid analogue (4-[[( 5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) Amino] Kerr Bonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5, 5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[((5,6-dihydro-5 , 5-Dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino] Benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5- Dimethyl-8- (2-fluorophenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,6-trimethyl) ] -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5 -Dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid Acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid Acid, 4-[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] oxy] benzoic acid Acid 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[((5,6-dihydro-5, 5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (4- Methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8- Phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4 -[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl - 8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxy Benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-[[[((5,6 -Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-Naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino ] Benzoic acid, 4-[[(5,6-dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl- 2-Naphthalenyl) carbonyl] amino] -3-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl) Enyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[((5,8,10,10a-tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] Benzoic acid, 4-[[(1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene -5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl- 3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or salts thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isoseaxanthin, rhodoxanthine , Carotenoids such as capsanthin and crocetin), lycopene or its salts and derivatives thereof, vitamin B group: thiami Or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisbutiamine, thiamine monophosphate disulfide, benfotiamine, chicotiamine, octothiamine, discetiamine, fursultiamine, prosultiamine, astaxanthin Thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosylnicotinamide pyrophosphate diester, 1 -β-D-ribofuranosylnicotinic acid, etc.), pyridoxine or its salts and derivatives thereof (pyridoxine 3,4-dipalmitate, pyridoxine 3,4-dicaprylate, pyridoxine sulfate diester, etc.), pyridoxer Or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, cyanocobalamin or salts thereof and derivatives thereof, cobalamines (such as methylcobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin), folic acid or salts thereof, and Derivatives thereof, nicotinic acid or salts thereof and derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof, choline or salts thereof and derivatives thereof, inositol or salts thereof and derivatives thereof , Vitamin C group: ascorbic acid or a salt thereof and derivatives thereof, vitamin D group: ergocalciferol or a salt thereof and derivatives thereof, cholecalciferol and a salt thereof and derivatives thereof (1α-hydroxy-22-[(1 -Hide Xyl-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4R] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4R] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4S] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group : Tocopherol or a salt thereof and derivatives thereof, Tocotrie Nord or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phytonadione or a salt thereof and derivatives thereof, menaquinone or a salt thereof and derivatives thereof, menadione or a salt thereof and derivatives thereof, menadiol Or salts thereof and derivatives thereof, vitamin F group: linoleic acid or salts thereof and derivatives thereof, linolenic acid or salts thereof and derivatives thereof, arachidonic acid or salts thereof and derivatives thereof, carnitine or salts thereof and Derivatives, ferulic acid or a salt thereof and derivatives thereof, γ-oryzanol or a salt thereof and derivatives thereof, orotic acid or a salt thereof and derivatives thereof, vitamin P group: rutin or a salt thereof and derivatives thereof, eriocitrin or a derivative thereof Salt and it Derivatives, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof and derivatives thereof, adenylthiomethylpentose or salts thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or derivatives thereof , Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, Histidine or its derivatives (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1-oxo Dodecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl- L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) Amino acids such as sulfates, phosphates, nitrates, citrates or amino acid derivatives such as pyrrolidone carboxylic acid, α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxy Tannic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid , Cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxy Ethanoic acid, 2- (3′-hydroxy-4′-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4′-hydroxy-3′-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2 ′ -Hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ', 4'-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythrone Acid, ribo Acid, arabinonic acid, xylonic acid, lyxonic acid, aronic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, taronic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), poly Hydroxycarboxylic acid or hydroxypolycarboxylic acid (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptono Lactones), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2- (Ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid , Citramalic acid, agaricinic acid, aleuricinic acid, pantoic acid, lactobionic acid, hexulosic acid, photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, pentadecanoic acid glyceride, linolenic acid or derivatives thereof, eicosapentaenoic acid or derivatives thereof Docosahexaenoic acid or a derivative thereof, estradiol, etenyl estradiol, antialol or a glycoside thereof, lionilesinol or a glycoside thereof, rhododendrol or a glycoside thereof, platyphyronol or a glycoside thereof, a lactone compound (D -Guruk Rono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D- Galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octa Neutic lactone, Nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyleuic-δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, Palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof, 6-benzylaminopurine or derivatives thereof, 1,4-diazadicyclooctane, 2,5 -Dimethylfuran, 2 -Methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylosylglucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandlapril Perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycine, proteoglycan, lactic acid bacteria extract, lactic acid bacteria culture extract, lactic acid bacteria fermented milk extract, bifidobacteria extract, bifidobacteria culture extract, bifidobacteria fermented milk extract, Placenta extract, reishi extract, spleen extract, thymus extract, yeast extract, yeast culture extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture extract, basidiomycete extract, basidiomycete Culture fluid extract, Bacterial cell disruption extract, Bacterial culture fluid extract, Cultured human dermis cell disruption extract, Red sage extract (Early yellow) extract, Fennel (mushroom) extract, Ezokogi (Kayagoka) extract, Barley (barley) extract, O Kururi Higotai (Zhengzhou Leopard) Extract, Root-knotweed Extract, Hypericum perforatum Extract, Dutch Jelly Extract, Dutch Honeybee Extract, Silkworm Extract, Roman Chamomile Extract, Garcinia Extract, Kawaran Ginseng (Blue Panax) Extract, Kakiran Extract, Kiraya Extract, Golden orchid extract, Ginkgo biloba extract, Calendula extract, Sakaneran (Ezosakakaneran) extract, Sababagin orchid extract, Sawagurumi extract (Plum) extract, Shimosukeso extract, Shajin extract, Plum extract, Gurumi extract, Sugina extract, Pineapple Pull extract, Chinese cabbage extract, Japanese cypress (shooting) extract, beech extract, physalis (Torone) extract, maitake (maiko) extract, Misohagi (Chikuma) extract, Mukuge (Kiso) extract, Mukuroji (life extension skin) extract, sprout Extract, Eucalyptus extract, Yukinoshita (tiger ear grass) extract, Suabisimus (cool) extract, Lettuce (Chisha) extract, Aloe extract, Ogon extract, Tonka bean extract, Gentianana extract, Burdock extract, Shikon extract, Carrot extract, Hamamelis extract, Hop extract, Yokuinin extract, Odorikosou extract, Senburi extract, Toki extract, Ginseng extract, Achacha extract, Hypericum extract, Cucumber extract, Ginger extract, Rosemary extract, Parsley extract, Sanadagusa extract, Fukurinamiji extract, Gatsu Lacombe Extract, Oyster Kumbu Extract, Oni Kumbu Extract, Gohei Kombu Extract, Naga Kumbu Extract, Pea Kombu Extract, Ouchimikombu Extract, Rattle Extract, Rattle Rape Extract, Beni Mozuku Extract, Hoso Beni Mozuku Extract, Kagekinori Extract, Ezotosaka Extract , Silamo extract, birch extract and the like.

Antioxidant An antioxidant can be added to the present invention. Specific examples of antioxidants include ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate aluminum Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid potassium phosphate, 6-o-alkylascorbic acid phosphate calcium Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, L-ascorbyl palmitate, L-isopalmitate Scorbyl, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, isomyristate L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α -D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D- Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitin Esters, L-ascorbic acid tetralaurate, L-ascorbic acid tetra-2-ethylhexanoate, L-ascorbic acid tetraoleate, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol Ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbine Acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4 ' -Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbic acid boar Binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or salts thereof and derivatives thereof (α-tocopherol) , Β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate , Tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl Glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-toco Ferryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ- Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ -Tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6- (Iloxy) propan-2-ol, 1- (carbo Cypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-Tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ- Tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), dihydropyridine derivatives (methyl-3- Enyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nordihydrogua ceretenoic acid, butyl Hydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, sesamol, sesamolin, gossypol, maritimane, sulfretin, xanthene -2,7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin, etc.), fluorotannin, Akebi extract, Achacha extract, Oolong Chaeki , Dutch villain extract, kanran extract, kumquat extract, gobishi extract, ginseng extract (old lady's grass) extract, sesame extract, sesame cell extract, sesame extract, ginseng extract, rice bran extract, pomegranate extract, salamander extract, pear Extract, Daio extract, Tomato extract, Nanten extract, Noisami extract, Neubara extract, paprika extract, pistachio extract, loquat extract, betel wax extract Buffalo extract, Bokeh extract, Hosobaoguruma extract, Mao (mao) extract, Mimosa extract, Mebouki extract, Himekuma willow extract, Yanagita extract, Watafujitsugi extract , Akaba Miuchiwa extract, Examples include Hypericum extract, Clam extract, Clove extract, Melissa extract, Enmezo extract, Birch extract, Salvia extract, Rosemary extract, Nanten extract, Ginkgo biloba extract, Green tea extract, Clove extract and the like.

Active oxygen scavenger / radical scavenger An active oxygen scavenger / radical scavenger can be added to the present invention. Specific examples of active oxygen scavengers and radical scavengers include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and derivatives thereof, curcumin Or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4′-o -β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester And derivatives thereof, chlorogenic acid glycolipid ester, chlorogenic acid sugar Steal, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxy- 5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives, (Logwood) extract, Akagasiwa (red bud) extract, Akamino akane extract, Anemone serrata extract, Akane (Harika) extract, Hydrangea (hydrangea) extract, Abemaki extract, Fig extract, Ginkgo biloba extract, Asparagus Extract, Japanese apricot extract, Japanese white beet extract, Japanese gourd extract, Estragon extract, Enju (Japanese cypress flower, Japanese coconut rice) extract, Japanese oak (Japanese cypress tree, Japanese maple leaf) extract, Japanese genus extract, birch extract, birch extract, Kunugi extract, Oleander extract, Kumiko mandarin (Koji, Tachibana, Obenimikan, Fukurikukan, Sagamikoji, Ponkan) extract, Santara extract, Coffee extract, Comfrey extract, Sasa extract, Perilla extract, Aojiso extract, chili mushroom extract, catamen diso extract, peonies (glaze) extract, Japanese oak extract, mizunara extract, crape myrtle extract, dicoppi extract, white birch extract, white clover (clover) extract, horseradish extract, black tea extract, green tea extract, tsububuki Extract, tencha (bamboo tea) extract, tender eel extract, nani waibara (gold cherry tree) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nicki extract, yabuni kei (cinnamon) extract, keishi (katsushi) extract, nozenkazura Extract, Lotus (Lotus) Extract, Chinese cabbage extract, Hadakagi Extract, Hanasuge (Kamika) Extract, Hermanus (Maika Flower) Extract, Rose (Rose) Extract, Barbasco Extract, Spinach Extract, Beech Extract, American Beech Extract, Dog Beech Extract, European beech extract, Convolvulus extract, Hosobaokera (蒼朮) extract, Button (peony) extract, Mayoram (Annelida) extract, Melon extract, Oenothera extract, Snowy willow extract, Orchid extract, Lacanca extract, Rooibos extract, Naminohana extract, Yukarie Vinegar, bombardier Yukari extract, Azusaekisu, basil extract, woodworking (climate) extract, Hime Fuuro extract, lemon grass extract, and the like.

Fat Metabolism Promoter A fat metabolism promoter can be added to the present invention. Specific examples of fat metabolism promoters include phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl- 1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxy) Phyllin and oxtriphilin, etc.) Extract Root) Extract, Ivy Extract, Pepper (Pepper) Extract, Cola Acminata Extract, Sagiomodaka (Sawamata) Extract, Pomelo Extract, Sansyuyu (Yamamuro) Extract, Tsuba Rafuji Extract, Ootsuki Rafuji Extract, Choreimaitake (Amber) Extract, Clover Extract , Prickly pear extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puer tea (common ear tea) extract, plum extract, boufu (windproof) extract and the like.

UV protection agent / UV absorption promoter An UV protection agent / UV absorption promoter can be added to the present invention. Specific examples of UV protection agents and UV absorption accelerators include benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5- Sodium sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3- Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinnamoyl) -3-rhamno L) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy-3-methoxycinna) Moyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-methoxyethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- (2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-methoxycinnamoyl) ) Glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1 -(2- (3-Allosyl-6- (3-hydroxy-4-methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinna Moyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2 -(3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene Paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, paradimethyla Amyl benzoate, octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, paramethoxycinnamate Potassium, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, Tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, Pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranin, 6-dehydrocarbine, triazine derivatives (4,4'4 "-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris- 2-ethylhexyl etc.), phosphatidyl chromanol derivatives (1,2-dilaurylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3- Phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-distearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-Tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'- Tramethyl-6′-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1- Myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho -2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetra Methyl-6′-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, etc.) , L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls , Escalol, Zinc Oxide, Talc, Kaolin, Anthrac (Buckthorn) Extract, Hub Extract, Giant Plover Extract, Asamidori Shigusa Extract, Kawachigusa Extract, Kawatake Extract, Cypridosa Extract, Hassai Extract, Spirulina Extract, Iacashio Extract, Funori no Ushike Extract , Japonicus extract, hyperus extract, oobusa extract, chinolimo extract and the like.

Astringents Astringents can be added to the present invention. Specific examples of astringents include succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamamelitannin Acer tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose, etc. Gallotannins, telimaglandin I, telimaglandin II, casarictin, peduncraggin, geraniin, isoturkevin, granatin A, granatin B, ketulinic acid, keblagic acid, casuarinin, nuphalin, procyanidin B-2, Eladitannins such as thiacinensin A and thiacinensin B), red grape extract, red bean extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezoba strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Nawashiro Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidney Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle Extract Q) Extract, larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mud dandelion extract, vine azuki bean extract, tsurutsu Akebi extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Buttercup extract, Hagoromogusa extract, Castor extract, Grape extract, Prune extract, Veronica extract, Bisnaga extract, Bilberry extract, Mansuguru extract, Mitsugashi extract, Myrrh extract, Melissa extract, Examples include witch hazel extract, bay willow extract, latania (chlamelia) extract, lemon extract, and dairy extract.

Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor An anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor can be added to the present invention. Specific examples of anti-inflammatory agents, interleukin production inhibitors and histamine release inhibitors include quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropyl Piperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d- Camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, hydrochloric acid Lomethazine, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or its salts and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α-glycyrrhizin Trisodium acid, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, monoammonium β-glycyrrhizinate ), Glycyrrhetinic acid or a salt thereof, and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl α-glycyrrhetinate, stearyl β-glycyrrhetinate, pyridoxine α-glycyrrhetinate, Pyridoxine ruretinate, glyceryl α-glycyrrhetinate, glycerin β-glycyrrhetinate, disodium 3-succinyloxyglycyrrhetinate, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenyl ether, etc. Panthenol or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexane) Carboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexane Carboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate Trans-4-p-bromobenzyloxycarbonylaminomethyl potassium cyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbonylaminomethyl Calcium tilcyclohexanecarboxylate, trans-4-p-methoxybenzyloxycarbonylaminomethyl magnesium cyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3, 5-Dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid , Sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) Calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine, trans -4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarbo Acid, sodium trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine-4'-methyl Oxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans -4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans-4- (2- Trimethylsilyl Ethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate, astaxanthin dipalmitoleate, Astaxanthin diheptadecanoic acid ester, astaxanthin dielaidic acid ester, astaxanthin diricinoleic acid ester, astaxanthin petroseric acid ester, astaxanthin vaccenic acid ester, astaxanthin eleostearic acid ester, astaxanthin punicic acid ester, astaxanthin ricinic acid ester, astaxanthin paris Naphosphate , Astaxanthin gadolinic acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin ceracholic acid ester, astaxanthin decenoic acid Ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid ester, astaxanthin dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaenoic acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinolenic acid ester, astaxanthin dilinolenic acid ester, astaxanthin diester Arachidonic acid ester ), Astaxanthin diglycerophosphate (astaxanthin diglycerophosphate, astaxanthin lyserophosphate palmitate, astaxanthin lysephrophosphatidylcholine palmitate, astaxanthin lysephrophosphatidylcholine DHA, astaxanthin lysephrophosphatidylinositol palmitate, astaxanthin Fattidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid, etc.), steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2 -(4- (1- (4,4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4 -(2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- ( 4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- ( 2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- ( 4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid), alanine derivatives or salts thereof (N- [3-isopentyl- 4-Methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H- Azoline-5-carbonyl] -L-alanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -2- Methylalanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -N-methyl-L-alanine, etc.) Thiazoline derivatives or salts thereof (3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acid mucos Polysaccharide or salt thereof Sulfated dextran or a salt thereof, fluoromethylhistidine or a hydrochloride thereof, histidine methyl ester or a hydrochloride thereof, licorice extract, sicon extract, age extract, propolis, eye (indigo leaf) extract, asenyaku (asen drug) extract, avocado extract, amadokoro (Bamboo bamboo) extract, Amiga lily extract, Baimo (shellfish mother) extract, Igakozorina (ground bile head) extract, Ibukitoranoo extract, Turmeric (Usu gold) extract, Echinashi (Hosobamurasakibarengiku) extract, Auren (Yoren) extract, Oguruma (turnover) extract, Hypericum persimmon (Brother cut grass) extract, Onigurumi extract, Orange extract, Cassia extract, Kamiyatsude (Tongweed) extract, Kawamidori extract, Kawara mugwort (Cotton chin) extract, Watercress extract, Kenashi Sartori Ibaraki , Gentian extract, co Ukisekoku extract, Kouhon (Kakimoto, Karamoto) extract, Koryokyo (Kora Kaki) extract, Gosho strawberry (covered bonsai) extract, Psycho-ran extract, Cherry extract, Salvia (sage) extract, Diquitaris extract, Linden extract, Salamander extract , Indobodai extract, Shukushamitsu (sand seed, shredded sand) extract, Juzudama extract, White minten (Nanten) extract, Ivy extract, Psyllium extract, Yarrow extract (Milfoil) extract, Shirohagenega extract, Takasago Gorhihitai Extract, Takara-bi (Kashiwaji) extract, Tachikakuso (Marika) extract, Tamatsuki-rafuji extract, Tounin extract, Chigaya extract, Toga (winter coconut) extract, Dokudami (ten-drug) extract, Parsley (Netherland jelly) extract, Shrimp (Shitushi, Shishitsuri extract, Hamasuge (Katsukiko) extract, Hishi (Hishimi) extract, Bellows oyster extract, Prunus quail (South rattan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Pansy extract, Hosoba aragiku (painful) Extract, Mizurutennansho (Tennansei) extract, pheasant (fruit) extract, miracle fruit extract, Munchroom extract, peach (peach) extract, cornflower extract, gourd willow extract, mistletoe (willow parasite) extract, Yabukouji (purple gold beef) extract, Porcupine extract, Artemisia (bamboo leaf) extract, Rosemary (Mannenrou) extract, Itohimehagi extract, Futosuzumo extract, Tamajuzumo extract, Mizojuzumo extract, Urushigusa extract, Siwahige extract, Akamok extract, Togemoku extract, Akaba extract, Maruba Aqaba Extract , Spinach extract, dulse extract, una extract, belladonna extract, cypress extract, harimille (crustacean, cinnabar skin, birch leaf) extract, Aozulan extract, sakaneran extract, sasabagin orchid extract, including varieties and origin species , Valerian extract, primrose extract, senkyu extract, kyonin extract, honeysuckle extract, tokyo extract, fennel extract, peppermint extract, and the like.

Anti-seborrheic agent An anti-seborrheic agent can be added to the present invention. Specific examples of the antiseborrheic agent include chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa extract, (Continuous) extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonso extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, Tokinsenka (marigold) extract, Chinese yam Examples include extract, yam extract, nosen-halen extract, dandelion poppy (sect winter flower, sect winter) extract, yabgarashi extract, giant kelp extract, hijirimen extract, primrose extract, haius banori extract.

Antibacterial Agent An antibacterial agent can be added to the present invention. Specific examples of antibacterial agents include acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salashi powder , Iodine compound, iodoform, 1-alkylcarbapenem compound, N-substituted azepane derivative or salt thereof, sorbic acid or salt thereof, propionic acid or salt thereof, salicylic acid or salt thereof, dehydroacetic acid, parahydroxybenzoic acid ester, 2 -Keto-3-deoxyoctanoic acid fatty acid esters, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ester Ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, Chlorobutanol, isopropylmethylphenol, elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl pheny Ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, Methyl rosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitizer 101, photosensitizer 201, photosensitizer 401, N-long chain acyl basic amino acid derivative and acid addition salt thereof, oxidation Zinc, hinokitiol, propolis, kudin extract, agi (Ayu) extract, asunaro extract, alpinia extract, katsudai (Suzukuku) extract, Inubilu extract , Ayuyu extract, Hagateto extract, Hosonagabiyu extract, Enmeiso extract, Warbler extract, Usubasaicin extract, Oshusaishin extract, Halibut extract, Ominaeshi extract, Kajikazura , Kahoku salamander extract, chamomile extract, linden extract, red linden extract, yellow spider extract, caraway extract, betel extract, beetle extract, cranberry extract, grapefruit extract, celosia flower (chicken flower, chicken crown) extract, Bay bay extract, Koushinbara (monthly flower) extract, Copaiba balsam extract, Yamazakura extract, Edhigashi extract, Miyaza cherry extract, Yoshino cherry extract, Kasami cherry extract, Kanza cherry extract, sugar beet extract, Sarashinashi Horse (Hemp) Extract, Sikunshi (Mikoshi) Extract, Birch Extract, Cinnamon Extract, Sorrel (Acid Model) Extract, Atlantic Dandelion Extract, Japanese Nezu (Etsumatsu) Extract, Japanese Pepper Extract, Wild Pepper Extract, Soka (Grass) Extract, onion extract, chicory extract, ginseng (蕪 夷) extract, tsuruna (apricot) extract, tokon (root) extract, leek extract, leek extract, peach extract, patchouli extract, ganbanana (stone carp, Vine extract, cypress extract, pimenta extract, white-bellied extract (black bald eagle) extract, blackberry extract, hop extract, sea chestnut extract Extract, purple (purple) extract, moso bamboo extract, pokeweed (commercial land) extract, yukkae , Lobster extract, Lavender extract, Forsythia extract, Sylar forsythia extract, Prunus nomata extract, Tochaka (Yahazutsu no Mata) extract, Red-breasted extract, Anaanaosa extract, Human egusa extract, Hirohi-no-higusa extract, Ushito exosa extract, Irolo extract , Ishige extract, arame extract, tamamitaki extract, tambanori extract, katanoori extract, cherry blossom extract, fujimatsumo extract, kawamozuku extract, aokawa mozuku extract, himeka mozuku extract, yakuchi (yachi) extract and the like.

Blood flow promoter and blood vessel stimulant A blood flow promoter and blood vessel stimulator can be added to the present invention. Specific examples of blood flow promoters and vascular stimulants include tocopherol or salts thereof and derivatives thereof, tocotrienol or salts thereof and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyleugenol, methyleugenol, methylisoeugenol, ethyl (Eugenol, ethylisoeugenol, eugenol salicylate, etc.), minoxidil, pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ectamol , Α-borneol, cyclandelate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract , Aloe extract, Gentian extract, Toki extract, Ashitaba (Tomorrow) extract, Arnica extract, Ukiyagara (Sanryo) extract, Himewiku extract, Citrus unshiu (Chest) extract, Toucan beetle (coconut) extract, Oyster extract, Persimmon extract, Kina extract, goldfish extract, pine moth (horse whip grass) extract, gubijinsou extract, kohone (river bone) extract, burdock (beef bowl, beef coconut) extract, scallop (Yamabachi) extract, syringen extract, ginger (ginger) extract, Shobu (bamboo root, radish) extract, hawthorn extract, sea bream (Otaku) extract, Daidai (orange peel) extract, tanjin (dansang) extract, thyme extract, chiketsu carrot (bamboo ginseng) extract, tsurudokudami (what neck crab) extract , Garlic extract , Scotchworm extract (Sadako), Natsumikan extract, elderberry (bone graft) extract, hazelnut (coconut) extract, Hashiridokoro (roth root) extract, mint (light load, thin load leaf) extract, Hamabou Fu (beach wind) extract, Higotai extract , Fujimodoki (Chojizakura, Camellia) extract, Black currant extract, Bodaiju (Aoki tree) extract, Merirot extract, Yuzu extract, Loquat extract, Japanese jelly extract, Hibiscus extract, Rosehip extract and the like.

Antiandrogen Agent An antiandrogen agent can be added to the present invention. Specific examples of antiandrogens include follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, 4 ′, 5,7-trihydroxy-8-prenylflavanone, 4 ′, 5,7-trihydroxy-8 -Prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporine and the like.

Structural proteinases (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme matrix metalloprotease) activity inhibitor / structural protein degrading enzyme expression inhibitor structure proteolytic enzymes in the present invention (elastase, collagenase, keratin, a serine protease, integrin enzymes, involucrin enzymes, filaggrin enzymes, laminin degrading enzyme, fibronectin degrading enzyme, a matrix such as proteoglycan degrading enzymes A metalloprotease) activity inhibitor / structural protease inhibitor can be added. Specific examples of structural proteinase activity inhibitors / structural proteinase expression inhibitors include adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, Pentanetriol-9-adenine and its phosphoric acid adducts), carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid) Acid, 1,10-decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor- 5 α-7,9 (11) -lanostadien-3,24-dione, ubiquinone, plastaquinone, yugro , Shikonin, quinizarin, alizarin, abietin, levopimaric acid, betulin, α-amylin, catechin compounds (catechin, epigallocatechin, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin rhamnopyranoside catechin, etc.), fluoro Diisopropyl phosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis-[( 1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2, 6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane- Dimethyl 1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyl Tyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy -4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,4,6-Trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6 -Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7 Dimethyl dicarboxylate, dimethyl (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy- 4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2, 6-Dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-( 2R, 6R) -2,6-Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -Amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -Tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chloro Biphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, 1- [4- (4-fluorobenzyl) Oxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -carbamic acid isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylpropionamide, 3- [4- (4-Fluorophenoxy) -benzenesulfonyl] -2, N-dihydroxypropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxy Amide, (4-benzylbenzyl)-[2- (2,2-dimethyl-1-methyl Rubamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl] -N-hydroxypropion Amide, N-Hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicus extract, Nepenthes (Summer hay) extract, Greater Crape myrtle (Banaba) extract, Big hawthorn extract, Hawthorn (Yamako) extract, Calahoo (Park) extract, guava extract, trash (Gomiko) extract, papaver extract, rose rose extract, Hypericum perforatum extract, chickweed extract , American Grape Extract, European Grape Extract, Yama Grape Extract, Mandarin Extract, Mishima Psycho (Shibahu) Extract, Ou Gon extract, Hypericum extract, Clara extract, Mulberry extract, Keihi extract, Gentian extract, Comfrey extract, Salvia extract, Elderberry extract, Body squirrel extract, Button pi extract, Aos zulan extract, Sakaneran extract, Sasabagin orchid extract, Chinese cabbage extract (variety and origin) (Including seeds) extract, red-green agave extract, sisal extract, garlic extract, and the like.

Structural protein synthesis promoter A structural protein synthesis promoter can be added to the present invention. Specific examples of structural protein synthesis promoters include ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3, 5,5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6 -Octenyloxy) methyl 2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5 -(3,5,5-trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate, 2-hydride Methyl xyl-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy) -2- Hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2-hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid Acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) -2-hydroxybenzoic acid Acid, 4-N-hexyloxy-2-hydroxybenzoic acid, 5-N-hexyloxy-2 -Hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) -2- Hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-ethylhexyloxy) -2-hydroxybenzoic acid sodium, 4- [(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate methyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] Ethyl-2-hydroxybenzoate, 5-[(2E) -3,7 dimethyl-2,6-octadienyloxy] -2-hydroxyethyl benzoate, 3-[(2E) -3,7-dimethyl- Ethyl 2,6-octadienyloxy] -2-hydroxybenzoate, ethyl 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoate, 4- [(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxybenzoate, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10 -Dodecatrienyloxy] -2-hydroxybenzoic acid methyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid (2E) -3,7- Dimethyl-2,6-octadienyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 5-[(2E) -3,7-dimethyl- 2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E ) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoic acid, 2-hydroxy-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10 -Dodecatrienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxybenzoic acid, 2-acetoxy-4-[(2E) -3 , 7-Dimethyl-2,6-octadienyloxy ] Benzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3, 7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxybenzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3 , 7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, 3 -Dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4 -(12-hydroxyoctadecyloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl- 2,6- Tadienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6 , 10-Dodecatrienyloxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl -9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5, 7,8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl -2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyloxy) benzamide 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoxy) Tadecyloxy) benzamide, 4- (11-hydroxyundecyloxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E ) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6, 10-dodecatrienyloxy] benzamide, N, N-di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[( 2E) -3,7-dimethyl-2,6-octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadienyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N, N-diethyl-4 -[(2E, 6E) -3,7,11-Trimethyl-2,6,10-dodecatrienyl Xy] -2-hydroxybenzamide, pea extract, red pepper extract, scots reed extract, hosobonori extract, bonito extract, igisu extract, keigi extract, harii squirrel extract, honey beet extract, euglena extract, moly rush extract, Willow extract, Willow extract, Motsuyurena extract, Venetian extract, Moth willow extract, Sabaya willow extract, Wasabi extract, Merbow extract and the like.

Mucopolysaccharides (hyaluronic acid, chondroitin sulfate, etc.) is the protease inhibitors present invention may contain a mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) protease inhibitors. Specific examples of mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors include anacardic acid or derivatives thereof (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecaic acid). Trienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6- Pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde Propyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6- Pentadecatrienyl cinnamate, 2-butyl ether-6-pentadecatrienyl cinnamate, 2-methyl ether-6-pentadecatrienyl cinnamate alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamate Alcohol, 2-propyl ether-6-pentadecatrienyl cinnamic alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamic alcohol), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol) , Isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso (October) extract, Narco lily extract, Occidental vanilla lily (Yellow) extract, Oregano extract, Oshida extract, Onji extract, Spruce extract, Crow birch extract (half-summer) extract, pheasant extract Skin) extract, goshyu extract, senega extract, sendan extract, tamarind extract, tarragon extract, ginkgo biloba extract, bee extract, daisy extract, mirabaran extract, himebara extract, Mockin Extract, Laurel Extract, Yabusotatsu Extract, Anaaaosa Extract, Macrocystis Integrifolia Extract, Neocitus Ruetkeana Extract, Nettle Extract, Prunus Extract, Kata-Bucka Extract, Yatabegusa Extract, Shimatengusa Extract, Ezotsunomata Kisses, Swallowtail extract, Fusiwa ivy extract, Hanemo extract, Mill extract, Chromel extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Orochi nori extract, Mafnori extract, Grape leaf extract, Salamander extract, Astragalus extract etc. are mentioned.

Mucopolysaccharide synthesis promoter A mucopolysaccharide synthesis promoter can be added to the present invention. Specific examples of the mucopolysaccharide synthesis accelerator include stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, scotch extract, breadfruit extract, hirakotoji extract , Kotojitsu no Mata Extract, Yaleus Banori Extract, Kagiosu Banori Extract, Susius Banori Extract, Amiaosa Extract, Nagaaosa Extract, Hosobanosakamodoki Extract, Hirohatosakamodoki Extract, Yatsudegatatosakamodoki Extract, Kurotosakamodoki Examples include extract, nematode salamander extract, Yusora extract, Echikinosa salamander extract, nankaitosakamodoki extract, Himetosakamodoki extract, and the like.

Intercellular lipid production promoter / intercellular lipid state improver An intercellular lipid production promoter / intercellular lipid state improver can be added to the present invention. Specific examples of intercellular adipogenesis promoters and intercellular lipid state improving agents include phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerin, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanol Amine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2- Azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosyl Lamide, galactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ketocholes Roll oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (gangliotriose, gangliotetraose , Globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyphyllin, 3-deazaadenosine, carboxamide derivatives, Inositol polyamines, sialic acid, triterpenic acid derivatives, lactose, lactosamine derivatives, sulfated chitin derivatives, albumin, ginseng extract, tochibanin ginseng extract, sea cucumber extract, red lily extract, green lily extract, chickweed extract And the like.

Keratin solubilizer and stratum corneum peeling accelerator A keratolytic agent and stratum corneum peeling accelerator can be added to the present invention. Specific examples of keratolytic agents and stratum corneum exfoliation accelerators include tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean extract, lentil extract Chickpea extract, mungbean extract and the like.

Plasminogen activator antagonist inhibitor A plasminogen activator antagonist inhibitor can be added to the present invention. Specific examples of the plasminogen activator antagonist inhibitor include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

Maillard reaction inhibitor A Maillard reaction inhibitor may be added to the present invention. Specific examples of Maillard reaction inhibitors include aminoguanidine, flavanones (naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, gallic tannin, tannic acid, (Geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, trigalloyl glucose, pentagalloyl glucose, digalloyl quinic acid, trigalloyl quinic acid), 2-hydroxyphenylalkylamine Derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6-trienoic acid, 3- (3,5-Dimethoxy-4-hydroxy (Roxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or its salts, gypsum extract, sandalwood extract, red clover extract, persimmon (柿(Including moths) Examples include Tarayo extract, Dokudami extract, Tormentilla extract, Bakumondo extract, Hiba extract, grape extract, Japanese willow extract, Mukuroji extract, Karin extract, Mokka extract, Roman chamomile extract and the like.

Testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter A testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter can be added to the present invention. Specific examples of testosterone 5α reductase activity inhibitor, hair papilla activator and hair growth promoter include γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β- Hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β- Hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxy Acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide) , Myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethyl) Aminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl Imidazolinium betaine), pyrimidine-N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine- 3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino -6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide, 2 -Amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamino- 4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5-piperidino -6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5-bromo-6- (1- Pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6-piperidinopyrimidine-3- Oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide monohydrochloride, 2- Acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) pyrimidine -3-oxide, 2,4- Amino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4- Diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, etc. ), P-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, monopentadecanoic acid glyceride sulfate, etc. -Monopentadecyl glyceryl ether sulfate, 1-o-hexadecyl-2-o-methylglycerin, 1-o-octadecyl-2-o-me Luglycerin, 1-o-oleyl-2-o-methylglycerin, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1 -Phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid), isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract) Proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-1, procyanidin B-2, procyanidin B-3, procyanidin C-1, etc.), aracaci extract, angelica extract, apricot extract , Hong anzu extract, Ichiyakuso (one herb) extract, Enishiidae Kiss, Psyllium (carrot, carp grass) extract, Psyllium shabushi extract, olive extract, giant pufferfish extract, seisei extract, calla cucumber extract, Chinese pear extract Camphor extract, kubeba extract, buckthorn extract, potato oyster extract, snapdragon extract, snapdragon extract, kippi extract, beetle extract, cilantro extract, kobushi extract, magnolia extract Extract, Consulango extract, Sasanqua extract, Sweet potato extract, Sanebuto jujube (acid soy sauce) extract, Sandscon (Yamazu root) extract, Potato extract, Shishigashira Kiss, Sanshishi extract, Coriander extract, Stevia extract, Takatodai extract (Otsuchi) extract, Tarayo (Ooba Fuyu Ao, Ichiha tea, Bitcho tea, Tofu tea) extract, Taranoki extract, Nigaki (Nakiki) extract, Nurde (penta) extract , Hakamauraboshi (bone crushing) extract, spider magnolia extract, scented squirrel extract, stag beetle extract, scallop extract, citron carrot (participant) extract, mangosteen extract, myoga extract, melaleuca extract, yashabushi extract, himeya chabushi extract , Oyaba chabushi extract, Yakumoso extract, Yamahanoki (Yamatake) extract, Longan (long-eye meat) extract, Lokon (Yoshi, Sone) extract, Logwood extract, Lantana extract and the like.

Hair matrix growth inhibitor / hair growth inhibitor A hair matrix growth inhibitor / hair growth inhibitor can be added to the present invention. Specific examples of hair matrix growth inhibitor / hair growth inhibitor include phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, methanolone, and ichihatsu (First) extract, citrus extract, kanto extract, sanjiko extract, silamo extract, sardine extract, scabbard fern extract, fritillary extract, honeysuckle extract, seaweed extract, oleander extract and the like.

Hair swelling agent / hair protecting agent A hair swelling agent / hair protecting agent can be added to the present invention. Specific examples of the hair swelling agent / hair protecting agent include ethanolamine, urea, guanidine, silicones, blueberry extract, mango extract and the like.

Odorous substance eliminating agent An odorous substance eliminating agent can be added to the present invention. Specific examples of the odorous substance eliminating agent include inondo extract, Elemi extract, vanillabins extract, pine extract and the like.

Other additive ingredients Specific examples of ingredients derived from plant raw materials used as an additive to the present invention include Aokazura (Keifuto) extract, Aotenma extract, Akasuguri extract, Aquine (crust) extract, Aguay Guasu extract, Abiyu extract, Abiurana extract, Yellow sapote extract, Ylang ylang extract, phalaenopsis extract, Uba tea extract, Ezo suzuran extract, Unboku extract, Elderberry extract, Ohisano Yuki extract, Sasa no Yuki extract, Toucan cactus extract, Omiya catechu extract, Onoelan extract, cynomolgus (Kinshato) extract, karaya extract, garyu extract, kawaratake extract, candelilla extract, canna extract, yellowfin mint extract, kimenakaku extract, cabbage extract, kiraja saponaria extract, ginsekai extract Kimbusen extract, guapeba vermelha extract, kugenumaran extract, gooseberry extract, crity river extract, curcrigo latifolia extract, black moth (rescue) extract, cucurian extract, sapotea mariyo extract, salmon berry extract, salamander extract, sankaku Cactus extract, Sunflower extract, Shunran extract, Shozuk extract, Shirobanatsuta extract, Cinconacill brabra extract, Swimberry extract, Star apple extract, Sulgaran (Oran) extract, Scots pine extract, Sunflower extract, Pteris Extract, mistletoe extract, sennin cactus extract, senboku extract, elephant crest extract, prunus extract, some mono-potato extract, darks Tote Cherry Extract, Prickly Pear Extract, Choco Stay Stay Extract, Datura Artemisia Extract, Vulgaris Extract, Tuxiabibi Extract, Licorice Extract (Duckweed) Extract, Duberry Extract, Papilio Kazura Extract, Tragacanth Extract, Triacanthus Extract , Neiseria berry extract, Rapeseed extract, Plover-dough extract, Pau doce extract, Hakuru berry extract, Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, Hinori duck extract, Himemuyoran extract, Brazil Carrot extract, Branjen extract, Fruceria extract, Blond psyllium extract, Hetsukaran extract, Henken extract, Berry extract, Persair extract, Pervianburg extract, Pereschia grandi Folia extract, Boysenberry extract, Hausairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, White berry extract, Masaran suba extract, Masheira de Boyi extract, Matta auryo extract, Mulberry extract, Midori sapote Extract, Murasaki Maize Extract, Megacansa Opuntica Extract, Mokukirin Extract, Momijidaio Extract, Morero Cherry Extract, Yakawa Murasaki Musa Extract, Cornflower Extract, Ruritama Thistle (Vulture), Red Currant Extract, Red Pitaya Extract , Plant extracts such as lemongrass extract, wax palm extract, logan berry extract and the like.

  In addition, as specific examples of components derived from plant-based materials used as additives to the present invention, Dunaliella genus Dunaliella extract, Quercus genus Kuwanomimo extract, Volbox genus genus sunflower extract, Volbox genus Volbox extract, Palmera extract, Yotsumemo extract, Aomido genus Chrysanthemum extract, Vulgaris extract, Hibimidro spp. Genus Black Ivy Extract, Casanori Genus Casanori Extract, Mika Ichiki Extract, Collecaete Extract, Tsutsumi Mimo Extract, Duckweed Genus Duckweed Extract, Sayamidro Extract, Kunshomo Extract Green algae extract such as Sumiremo violet reed extract, Hosimidro extract, Fuchinasimidro extract Genus Isogawara extract, black moth genus black moth extract, mosquito genus mosquito extract, whip squirrel extract, scallop squirrel extract, squirrel squirrel squirrel extract, common squirrel genus extract, common squirrel genus genus Hiranamikurakura extract, Somerna spruce extract, Navarimo spruce extract, Chawomen spruce extract, Nagamatsu Genus Nagamatsumo extract, Niseft mozuku niseft mozuku extract, Futomozuku genus mozuku extract, Kuromo genus kuromo extract, Nisemo genus nisemozuku extract, Ichimegasa Ichimegasa extract, zelkova quail extract, Umibos genus Citrus genus Compositae extract, Haberomodo spp. Extract, genus Cyprus extract, genus genus genus extract, genus turmeric extract, genus chrome extract, chrysanthemum Brown algae extract such as Bucus spp. Milnobeni extract, Konahada spp. Sodegarami Sodegarami Extract, Hirohata Tadaki Genus Hirota Maitake Extract, Tengusa Nambugusa Extract, Tengusa Kohira Extract, Tengusa Yohira Extract, Tengusa Kinukusa Extract, Billow hibishiro extract, Hibiro hibishiro extract, Rhizoma genus extract, Rhizome genus extract, Ryumon genus Ryumon extract, Ryumon genus Hera ryumon extract, Nisekarekigusa genus naruto Ganoderma spp. Centipede extract, Centipede spruce extract, Centipede spider extract, Centipede extract, Centipede extract, Centipede extract, Centipede extract Marubadara extract, Hiramitoki Hirakintoki extract, Matabouja Matabou extract, Kintoki Chabokintoki extract, Kintoki Kintoki extract, Kintoki Ginseng extract, Kintoki Tosaka pine extract, Kintoki Hamamatsu extract, Kintoki Fushikintoki extract, Kintoki Toki Tokiki extract Centipede extract, Kintoki spp., Kintoki sp. Anemone caulimenia extract, Honoho genus Honoo extract, Hikeno genus genus genus extract, Hydra genus Usuginu extract, Nikuhou Ganoderma genus extract, Venetian genus Venetianago extract, Suscabeni genus Suscabeni extract, Okamuragusa porcupine extract, Isomocca isomocca extract, Kizinogi genus extract, Isodantsu isodantsu extract, Atsunori genus Atsubanori extract, Ogonori genus Mizoogonori extract, Ogonori genus Beniogonori extract, Ogonori sp. Ogonori genus Ogonori extract, Ogonori genus tsutsuginu extract, Ogonori genus Ogonori extract, Ogonori Kubireogonori extract, Ogonori mosasaogori extract, Ogonori genus Nukabanori extract, Namiiwatake spp. Goat's extract, Taogi's genus Hanasakura extract, Fukutsunagi genus Fukutsunagi extract, Fukutsunagi spp. , Benifukuronori genus Benifukuronori extract, Villus spp. Nori Egonori Extract, Egonori Futogigi Extract, Saeda Saeda Extract, Chirimomiji Chiri Momiji Extract, Habutaenori Extract, Coniferous Extract, Suzushironori Extract, Usbeni Usbeni Extract, Hasujiginu Hasujiginu Extract, Nagakonohigani Extract Genus Sugiginu extract, Sugiginu genus Atsubasjiginu extract, Heius banori Kagious banori extract, Heius banori genus Yaleus banori extract, haius banori genus Suus banori extract, haius banori genus euus banus extract, genus genus genus genus Ayanishiki extract, Ayaginu Ayaginu extract, Dadia Enashida extract, Shimadadia Isohagi extract, Shimadadia Shimadadia extract, Dajimodoki daji Modoki extract, Makuri genus extract, Hanegusa genus extract, Hanegusa genus extract, Kozanemo genus Kozanemo extract, Kozanemo genus Isomurasaki extract, Kozanemo genus Hozo moss extract, Himego genus Himegoke extract, Himego genus Kurohegoshi extract Hyodosig genus Hyodosigusa extract, Hyodosig genus Usubahiodoshi extract, Isomegusus genus Isomegusa extract, Suginassa genus Sugenashigusa extract, Isobasho genus Isobasho extract, Ideyugogome genus Yuukogome extract, Ochimomoku genus Ochichimokuzhizuzuri zukisuji Red algae extract, Shajikumo extract, Shiratamamo extract, Hoshitsurimo Hoshitsurimo extract, Rikunotamnusu extract, Flascus spp. , Axle algae extracts such as chabo flask extract and tripella extract, yellow algae extracts such as Hikarimo Hikarimo extract, and the like.

  Specific examples of ingredients derived from animal materials used as an additive to the present invention include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or degradation product thereof, cow Or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk protein and Degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation products thereof or Derivatives thereof, skim milk powder and decomposition products thereof or derivatives thereof, lactoferrin or decomposition products thereof, egg components, fish decomposition products And nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) and the like.

  Specific examples of components derived from microbial raw materials used as additives for the present invention include yeast metabolites, yeast extract extracts, bacterial metabolites, bacterial extract extracts, metabolites such as fungi or mushrooms, actinomycetes metabolites, fungi Or extracts such as mushrooms, actinomycetes extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice bran, birch) fermented extract, euglena extract or a decomposed product thereof, or their water-soluble derivatives, raw milk or defatted Examples include lactic acid fermented milk powder.

  Furthermore, any part, cell, tissue, organ, metabolite, etc. derived from a transgenic or cell fusion can be used as the plant, animal or microbial material. Furthermore, it can be obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cells, etc.), undifferentiated cells, cells in the middle of differentiation, metabolites thereof, and the like can also be used.

  Specific examples of the components of natural raw materials used as additives include seawater such as deep sea water, for example, sea salt, dried seawater, Dead Sea, Atlantic Ocean or Pacific Ocean. Potassium, etc.), sea mud or mud (Fango), for example, Italian mugo, German fungo, Eifelfango, Freiburg Fango, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, natural smectite , Bentonite, hectorite and the like.

  Extracts derived from plant raw materials, animal raw materials, microbial raw materials, and other natural product raw materials used as additives are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, Treatment, extraction, decomposition, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. ) And any one of various materials may be selected for use.

  The solvent used for the extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol, Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, alcohols T, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, and other organic solvents, and acids prepared with appropriate normality (hydrochloric acid, sulfuric acid, It is desirable to use one or a mixture of two or more selected from nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. It may be extracted after squeezing.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, bromelain, thermolysin, pronase, pepsin, rennin, pan Proteolytic enzymes (proteases) such as creatine, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as pectinase, polygalacturonase, dextranase, planarase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, turnip lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, chitinase, etc. Cell wall lytic enzyme. In the degradation with an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, etc. can be set arbitrarily, but it is particularly preferable to set the optimum value for the enzyme used.

  Fermentation or metabolic conversion by microorganisms can be performed by inoculating and growing at least one kind of microorganism on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. As the microorganism to be used, for example, as microorganisms classified into yeast, the genus Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ashbia, Ashbya, Asporomyces, Atelosaccharomyces Genus, Azymoprocandida, Babjevia, Ballistosporomyces, Bensingtonia, Blastobotrys, Blastodendrion, Blastoderma, Blastoschizomyces, Botryoascus, Botryozyma, Brettanomyces, Brettanomyces bruno, Cullus Genus (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsii, Candida famata, Candida fermentati, Candida guilliermondii, Candida halophila, Candida krusei, Candida krusei, Candida krusei, Candida krusei, Candida krusei Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc.), Castellani Genus a, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, Cryptococcus, Debaryomyces (Debaryomyces delbrueckii, Debaryomyces halotolerans, Debaryomyces hansenii etc.), Deberoozyma, Debaryozyma, Dipodascus, Eeniella, Endomyces, Endomycopsis, Eremascus, Eremothecium, Eutorulopsis, Fabospora, Fellomyces, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, anomala, Hansenula kluyveri, Hansenula miso, Hansenula polymorpha, Hansenula wickerhamii etc.), Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Kloeckera fluoresceny, Kloeckera Etc.), Kockovaella genus, Kurtzmanomyces genus, Leucosporidium genus, Lipomyces genus, Metschnikowia , Microanthomyces genus, Monilia genus, Monospora genus, Monosporella genus, Mrakia genus, Myceloblastanon genus, Mycocandida genus, Mycoderma genus, Mycotorula genus, Mycotoruloides genus, Myxozyma genus, Nadsonia sp Genus, Oospora, Oosporidium, Pachysolen, Parasaccharomyces, Paratorulopsis, Parendomyces, Petasopsora, Pichia (Pichia amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia moc Genus, Proteomyces genus, Pseudomonilia genus, Pseudosaccharomyces genus, Pseudozyma genus, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae Genus, Saturnispora, Schizoblastosporion, Schizosaccharomyces, Schwanniomyces Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus genus, Sporobolomyces genus, Sporothrix genus, Stephanoascus genus, Sterigmatomyces genus, Sympodiomyces genus, Symingospora genus, Tetrapisispora genus, Torulaspora genus, Tordenpostomy genus, Torulopsiron genus, Torulopsisces genus Genus William, genus Williamopsis, genus Wingea, genus Xanthophyllomyces, genus Yamadazyma, genus Zendera, genus Zygofabospora, genus Zygopichia, genus Zygosaccharomyces, genus Zymodebaryomyces and the like. The microorganisms classified as bacteria include the genus Acetobacter (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadospura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellatospora, Cellulomonas sp Enterobacter sp Genus, Halobacterium genus, Halococcus genus, Herbidospora genus, Hydrogenophilus genus, Hyphomicrobium genus, Hyphomonas genus, Intrasporangium genus, Janibacter genus, Kinesia spp. Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus divergens, Lactob acillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri , Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobacillus jugurt, Lactobacillus caucasicus Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, such as Leuconostoc citrovorum), Listonella Genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum genus Mesorhizobium genus, Metallosphaera genus, Methylobacterium genus, Microbispora genus, Micrococcus genus, Microellobosporia genus, Micromonospora genus, Mycobacterium genus, Nocoides genus, Noiaides Genus, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus (Pediococcus cerevisiae, Pediococcus pentosaceus, Pediococcus urinae-equi etc.), Pedobacterto, Pedobacterto , Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Pseudonocardia, Rahnella, Rarobacter, Rathayibacter, Rhizobium, Rhizomonas , Rhodospirillum genus, Rothia genus, Rubrobacter genus, Ruegeria genus, Saccharomonospora genus, Saccharothrix genus, Serratia genus, Sinorhizobium genus, Sphingobacterium genus, Sphingomonas genus, Sporolactobacillus genus, Stenotrophomonas genus, Streptoalloteococ genus Streptoalloteococ faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactisdy uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.), Streptomyces genus, Streptosporangium genus, Streptoverticillium genus, Terrabacter genus, Thermoactinomyces genus, Thermobifida genus, Thermobispora genus, Thermohispera genus, Thermohispa genus, Thermopispa genus, Thermopispa genus, Thermopispa genus Genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as ascomycetes, basidiomycetes or incomplete fungi other than yeast include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria Botryotinia sp Genus, Dothidea genus, Endogone genus, Entomophthora genus, Emericella genus, Eupenicillium genus, Eurotium genus, Exobasidium genus, Gibberella genus, Glomus genus, Graphiola genus, Gymnoascus genus, Harpella genus, Helicomyces genus, Helvella genus, Hemicarpenteles genus, Hyphochytrium genus, Hyphochytrium Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium, Microascus, Microstroma, Medeololaria, Melampsora , Melamsporella, Morchella, Monascus, Monilinia, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olpidium, Peziza, Penicillium, Perenospora, Pestopolisis Genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia genus, Sclerocleista genus, Saprolegnia genus, Sclerotinia genus, Sclerotum genus, Septobasidium genus, Septobasidium genus Examples include Sporidiobolus genus, Stigmatomyces genus, Sydowiella genus, Talaromyces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, sugar, ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerin, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salts, urea, uric acid, amino acids, etc. Vitamins and compounds containing potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.) fractionation using a single column or multiple columns, dialysis with semipermeable membranes, crystallization and recrystallization of components. Examples thereof include crystallization, filter paper, membrane filter, ultrafilter, filtration using activated carbon and filter aid, centrifugal separation and its application, fractional precipitation method, density gradient separation method such as density gradient sedimentation equilibrium method, and the like.

Specific examples of other components other than the above used as additives in the present invention include silicic anhydride, magnesium silicate, talc, kaolin, bentonite, hectorite, natural or synthetic smectite, stevensite, mica, mica titanium, oxy Inorganic pigments such as bismuth chloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate , Silicic acid Thorium hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide and other inorganic reducing agents , Redox agents such as thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino-4 -Nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene hydrochloride -2,5-diamine, nitroparaphenylenediamine hydrochloride , Paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxy Naphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, meta Phenylenediamine, 5-aminoorthocresol sulfate, sulfuric acid 2-amino-5-nitrophenol, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparasulfate Phenylenediamine, sulfated paraaminophenol, sulfated paranitroorthophenylenediamine, sulfated paranitrometaphenylenediamine, sulfated paraphenylenediamine, sulfated paramethylaminophenol, sulfated metaaminophenol, sulfated metaphenylenediamine, catechol, diphenylamine, α-naphthol, Dye agents such as hydroquinone, phloroglucin, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein, natural animal incense such as musk, civet, castrium, ambergris , Anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, Coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, Western mint essential oil, otsuki aroma essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam Essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peru balsam essential oil, boadrose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime Oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, vegetable flavors such as Japanese mint essential oil, other synthetic flavors, 5-amino-o-cresol, o-aminophenol, m -Aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N , N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5- Nitro-2 ', 4'-diaminoazobenzenesodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydroxyl) -p- Phenylenediamine, N, N-bis (2-H (Droxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine sulfate, 2- (2'-hydroxyethylamino) -5 -Aminotoluene sulfate, 4,4'-diaminodiphenylamine sulfate, p-methylaminophenol sulfate, p-phenylenediamine sulfate, m-phenylenediamine sulfate, toluene-2,5-diamine sulfate, 2, 4-diaminophenoxyethanol hydrochloride, toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2,4-diaminophenol hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine hydrochloride, N -Phenyl-p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N'-bis (4 -amino Nyl) -2,5-diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino -5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picrate, 2-amino- 5-nitrophenol sulfate, resorcinol, nitro-p-phenylenediamine sulfate, p-nitro-o-phenylenediamine sulfate, p-nitro-m-phenylenediamine sulfate, red No. 2, red No. 3, red 102 No., Red 104 (1), Red 105 (1), Red 106, Red 201, Red 227, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401, Red 502, Red 503, Red 504, Red 506, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402, Yellow 403 (1), Yellow 406, Yellow 407 , Orange 205, orange 207, orange 402, green 3, green 204, green 205, green 401, green 402, brown 201, purple 401, blue 1, blue 2, blue No. 202, Blue No. 203, Blue No. 205, Black No. 401, Red Cabbage Dye, Red Spider Dye, Catechol Tannin, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber Dye , Caramel, gold, silver, gardenia pigment, corn pigment, onion pigment, tamarind pigment, spirulina pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, grape skin pigment, marigold pigment, purple potato pigment, purple yam pigment , Pigments and colorants such as lac dye and rutin, avocado oil, Almond oil, fennel oil, sesame oil, olive oil, orange oil, orange raffer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower oil, shea fat, liquid shea fat, large Bean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard Oils such as hydrogenated products (hardened oil, etc.), waxes such as beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc. , Liquid paraffin, petrolatum, paraffin, ozokelide, selenium , Mineral oil such as microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, Natural fatty acids such as tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid and other fatty acids such as ethanol, isopyropanol Natural alcohol such as lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-hexyldecanol, isostearyl alcohol, 2-octyldede Alcohols such as synthetic alcohol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, adipine Diisobutyl acid, 2-hexyldecyl adipate, diheptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol diethyl hexanoate, neopentyl glycol diethyl hexanoate, 2- Cetyl ethylhexanoate, trimethylolpropane triethylhexanoate, pentaerythritol tetraethylhexanoate, cetyl octanoate Octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, aluminum stearate, magnesium stearate , Zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, etc., anionic surfactants (alkyl carboxylates, alkyl sulfonates, alkyl sulfates, alkyls) Phosphate ester salt), alkyl sulfate ester salt (sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, cetyl sulfate) Sodium, sodium stearyl sulfate, etc.), secondary alcohol sulfate, alkyl ether sulfate (e.g., polyoxyethylene lauryl sulfate triethanolamine, polyoxyethylene lauryl sodium sulfate, etc.), alkyl and alkyl allyl ether sulfate ( N-acyl methyl alanine salt, N-acyl glutamate, N-acyl methyl taurate, N-acyl isethionate, N-acyl glycine salt, alkyl phosphate, alkyl ether carboxylate, alkyl sulfonate, alkyl sulfosuccinate Acid salt, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene lauryl ether ammonium sulfate, polyoxyethylene alkyl ether sulfate Acid sodium, polyoxyethylene alkyl ether sulfate triethanolamine, polyoxyethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether ammonium sulfate, etc.), higher fatty acid alkylolamide sulfate ester salt, higher fatty acid ester sulfate ester salt (hardened coconut oil fatty acid) Sodium glycerine sulfate, etc.), polyoxyethylene alkyl ether carboxylic acid, polyoxyethylene alkyl allyl ether carboxylate, sulfated oil such as sulfated castor oil, mono or dialkyl or alkenyl phosphate ester salt, polyoxyethylene mono or dialkyl Or alkenyl phosphate ester salts (sodium monolauryl phosphate, sodium isostearyl phosphate, arginine 2-hexyldecyl phosphate, 2-heptyl undecyl Potassium phosphate, polyoxyethylene (4-10) lauryl
Sodium ether phosphate, sodium monocetyl phosphate, arginine monomyristyl phosphate, sodium monooleyl phosphate, potassium polyoxyethylene (2-10) lauryl ether phosphate, sodium dioctyl phosphate, etc.), polyoxyethylene alkyl ether phosphate Ester salts (polyoxyethylene lauryl ether phosphate, polyoxyethylene oleyl ether phosphate, polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether phosphate, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkyl phenyl ether phosphate Acids), higher fatty acid amide sulfonates or higher fatty acid ester sulfonates (α-olefin sulfonate, N-myristoyl-N-methyltaurine sodium, coconut oil fatty acid) Tiltaurine sodium, sodium lauroylmethyl taurate, etc.), alkylbenzene sulfonate (dodecylbenzenesulfonic acid, monoethanolamine dodecylbenzenesulfonate, diethanolamine dodecylbenzenesulfonate, triethanolamine dodecylbenzenesulfonate, sodium dodecylbenzenesulfonate, etc.) , Sulfosuccinate (sodium diethylhexylsulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, disodium polyoxyethylenesulfosuccinate, disodium lauryl polyoxyethylenesulfosuccinate, disodium polyoxyethylene lauroyl ethanolamide ester sulfosuccinate, Undecylenoylamidoethylsulfosuccinate disodium, monora Rhoyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.), N-acyl sarcosine salts (such as sodium lauroyl sarcosine, palmitoyl sarcosine sodium), condensates of higher fatty acids and amino acids (N-acyl glutamate, Sodium N-stearoyl glutamate, potassium N-palmitoyl glutamate, sodium N-lauroyl-L-glutamate, disodium N-stearoyl-L-glutamate, sodium N-myristoyl-L-glutamate, sodium myristoyl methyl taurate, sodium palmitoyl methyl taurate, (Stearoylmethyl taurine sodium, N-palmitoyl-β-alanine arginine, N-palmitoyl aspartate ditriethanolamine, etc.) , Anionic surfactants such as fatty acid soaps such as oleate, suarenate, laurate, palmitate (as salts of anionic surfactant, for example, alkali metal salts such as sodium salt, potassium salt, Monoethanolamine salt, diethanolamine salt, triethanolamine salt, L-lysine salt, organic ammonium salt such as L-arginine salt, ammonium salt etc.), quaternary ammonium salt (alkyltrimethylammonium chloride, cetylammonium chloride) , Cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, stearyl dimethyl chloride Monium, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dicetyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide, distearyl ammonium chloride, odor Distearylammonium chloride, dicetylmethylammonium chloride, dicetylmethylammonium bromide, dilaurylmethylammonium chloride, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearylmethylammonium bromide, cetyltrimethylammonium chloride, odor Cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, lauric bromide Ditrimethylammonium chloride, dialkyldimethylammonium chloride, dicetyldimethylammonium chloride, distearyldimethylammonium chloride, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium chloride Cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyethylmonium metasulfate, dicocoylethylhydroxyethylmonium Tasulfate, dipalmitoylethylhydroxyethylmonium metasulfate, and cetyltriethylammonium methyl sulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium bromide, alkylpentaethoxyammonium chloride, ditallowdimethyl Ammonium chloride, ditallow dimethyl ammonium methyl sulfate, ditallow dipropyl ammonium phosphate, ditallow dimethyl ammonium nitrate, di (coconut alkyl) dimethyl ammonium chloride, di (coconut alkyl) dimethyl ammonium bromide, coconut ammonium chloride, stearamide propyl chloride PG-dimonium phosphate, stearamide Pyrethyl dimonium esosulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl dimethyl ammonium chloride, stearamide propyl dimethyl ammonium lactate, lanolin fatty acid ethyl sulfate Aminopropylethyldimethylammonium, cationized cellulose, acyldiethylaminoethylamide, acyldimethylaminopropylamide, polyoxyethylene fatty acid amide, myristyldimethylamine oxide, N-lauryldimethylaminoacetic acid betaine, N-myristyldimethylaminoacetic acid betaine, N- Stearyldimethylaminoacetic acid betaine), bis-fatty acid ester salt (hydroxypropyl-bis-lauric acid) Midopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palmitic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis -Stearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-dimethylammonium chloride, Hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palm Fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-lauric acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl -Bis-myristate amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palmitamidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidoethyl stearate-N, N-diethylammonium chloride, hydroxy Propyl-bis-behenic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidoethylammonium chloride, hydroxypropyl-bis-isostearic acid amido-N , N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidoethyl- N, N-diethylammonium chloride, hydroxypropyl-bis-lauramidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristate amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palmitin Acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-di Tyl ammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidopropyl isostearate-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl- N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-diethylammonium chloride), stearamidepropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamide propyl ethyl dimonium ethosulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride , Cationic surfactants such as stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldimethylammonium chloride, stearamidepropyldimethylammonium lactate, glycerin fatty acid ester (glyceryl monoundecylenate, glyceryl diundecylenate, Glyceryl monomyristate, glyceryl dimyristate, glyceryl monopalmitate, glyceryl dipalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, monostearate Acid glycerin, α, α'-oleic acid pyroglutamate glycerin, monostearate glycerin malate, etc.), polyglycerin fat Acid esters (diglyceryl monomyristate, diglyceryl dimyristate, diglyceryl trimyristate, diglyceryl monopalmitate, diglyceryl dipalmitate, diglyceryl tripalmitate, diglyceryl monostearate, diglyceryl distearate, Diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, diglyceryl trioleate, tetraglyceryl monopalmitate, tetraglyceryl dipalmitate, tetraglyceryl tripalmitate, tetraglyceryl tetrapalmitate, pentapalmitic acid Tetraglyceryl, tetraglyceryl monostearate, tetraglyceryl distearate, tetraglyceryl tristearate, tetraglyceryl tetrastearate, Tetraglyceryl tantalate, tetraglyceryl monooleate, tetraglyceryl dioleate, tetraglyceryl trioleate, tetraglyceryl tetraoleate, tetraglyceryl pentaoleate, hexaglyceryl monopalmitate, hexaglyceryl dipalmitate, tripalmitic acid Hexaglyceryl, hexaglyceryl tetrapalmitate, hexaglyceryl pentapalmitate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, hexaglyceryl tetrastearate, hexaglyceryl pentastearate, hexaglyceryl monooleate, Hexaglyceryl dioleate, hexaglyceryl trioleate, hexaglyceryl tetraoleate Penta oleic hexaglyceryl monopalmitate decaglyceryl dipalmitate decaglyceryl, decaglyceryl tripalmitate, Tetoraparu
Decaglyceryl mytilate, decaglyceryl pentapalmitate, decaglyceryl hexapalmitate, decaglyceryl heptapalmitate, decaglyceryl octapalmitate, decaglyceryl nonapalmitate, decaglyceryl monostearate, decaglyceryl monostearate, decasteryl distearate Glyceryl, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, decaglyceryl octastearate, decaglyceryl nonasterate, decaglyceryl decastearate, Decaglyceryl monooleate, decaglyceryl dioleate, decaglyceryl trioleate, decaglyceryl tetraoleate , Decaglyceryl pentaoleate, decaglyceryl hexaoleate, decaglyceryl heptaoleate, decaglyceryl octaoleate, decaglyceryl nonaoleate, decaglyceryl monohydroxystearate, decaglyceryl dihydroxystearate, decaglyceryl dihydroxystearate, tri Decaglyceryl hydroxystearate, decaglyceryl tetrahydroxystearate, decaglyceryl pentahydroxystearate, decaglyceryl hexahydroxystearate, decaglyceryl heptahydroxystearate, decaglyceryl octahydroxystearate, decaglyceryl nonahydroxystearate, decahydroxyl Decaglyceryl stearate, hexaglyceryl polyricinoleate, polyricino Decaglyceryl phosphate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, polyoxyethylene glyceryl monooleate, polyoxyethylene glyceryl monomyristic acid), polyoxyethylene glycerin fatty acid ester (polyoxyethylene glycerin monoester) Stearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate, etc.), sorbitan fatty acid ester (sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan monopalmitate) Sorbitan monostearate, sorbitan distearate, sorbitan dioleate, sorbitan monopalmitate, tris Sorbitan oleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxymonopalmitate Ethylene sorbitan, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate, propylene glycol fatty acid ester (propylene glycol monooctanoate, propylene glycol monodecanoate, propylene glycol monostearate, etc.) ), Sucrose fatty acid ester (monolauric acid sucrose ester, dilauric acid sucrose ester, monopalmitic acid sucrose ester Dipalmitic acid sucrose ester, monostearic acid sucrose ester, distearic acid sucrose ester, etc.), dextrin fatty acid ester (such as dextrin palmitate), coconut oil fatty acid alkanolamide, polyoxyethylene castor oil, polyoxyethylene cured Castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, polyoxyethylene hydrogenated castor oil maleic acid, polyoxy Ethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene behenyl ether, polyoxyethylene olei Ether, polyoxyethylene lauryl ether, polyoxyethylene-2-octyldodecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxyethylene alkyl phenyl ether (polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), Polyoxyethylene fatty acid esters (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene sorbitol lanolin, etc.), POE / POP -Alkyl ethers (POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated Rano Nonionic surfactants such as phosphorus, POE / POP-glycerin ether, tetronic, etc.), alkanolamides (coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.), betaine-type amphoteric surfactants ( 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, undecylcarboxymethoxyethylcarboxymethylimidazolinium betaine sodium, undecylhydroxyethylimidazolinium betaine sodium, undecyl-N -Hydroxyethyl-N-carboxymethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, stearyl dihydroxyethyl betaine, stearyl dimethylaminoacetic acid betaine, stearyl di Sodium methylbetaine solution, coconut oil alkyl-N-carboxyethyl-N-hydroxyethyl imidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine, coconut oil fatty acid-N- Carboxymethoxyethyl-N-carboxyethylimidazolinium betaine sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-cocoyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, Lauryldimethylaminoacetate hydroxysulfobetaine, palm oil alkyldimethylaminoacetate hydroxysulfobetaine, laurylaminopropionate triethanolamine, β-laurylaminopropionate sodium, lauryl Amidopropyldimethylaminoacetic acid betaine, lauric acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, palm oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid Betaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine, lauryldiaminoethylglycine sodium, lauric acid amidopropyl betaine solution, lauryl sulfobetaine, Lauryl hydroxysulfobetaine, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium Betaine, Cocodimethylcarboxymethylbetaine, Lauryldimethylcarboxymethylbetaine, Lauryldimethylalphacarboxyethylbetaine, Cetyldimethylcarboxymethylbetaine, Cetyldimethylbetaine, Laurylbis- (2-hydroxyethyl) carboxymethylbetaine, Stearylbis- (2-hydroxy (Propyl) carboxymethylbetaine, oleyldimethylgamma-carboxypropylbetaine, laurylbis- (2-hydroxypropyl) alpha-carboxyethylbetaine, cocodimethylsulfopropylbetaine, stearyldimethylsulfopropylbetaine, lauryldimethylsulfoethylbetaine, laurylbis- (2 -Hydroxyethyl) sulfopropyl betaine, Levon 2000 (Sanyo Chemical Co., Ltd.), palm oil fatty acid amidopropyl di Methylbetaine, coconut oil fatty acid amidopropylsulfobetaine, imidazolinium-type amphoteric surfactant (bis (stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, N-alkyl-N-carboxymethyl-N-hydroxyethylimidazoli Nitrobetaine, N-alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine-lauryl sulfate and its salts, coconut oil alkyl-N-carboxyethoxyethyl-N-carboxyethylimidazolinium disodium hydroxide, coconut oil alkyl- N-carboxymethoxyethyl-N-carboxyethylimidazolinium disodium hydroxide, palm oil alkyl-N-carboxymethoxyethyl-N-carboxyethylimidazolinium disodium lauryl sulfate, 2-undecyl-N, N, N- (Hydroxyethylcarboxymethyl) -2- Aminopropionic acid type amphoteric interface such as sodium midazoline, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, ovazoline 662 (Toho Chemical Co., Ltd.), Swanol AM-101 (Nikko Chemicals Co., Ltd.) Activator (alkylaminopropionic acid such as sodium dodecylaminopropionate, alkylaminodipropionic acid, etc.), sodium dodecylaminopropanesulfonate, N-higher alkylaspartic acid or its salt, coamidopropyl chloride polyethylene glycol dimonium phosphate , Cocamidopropyl hydroxysultain, sodium lauroyl sarcosinate, alkylamine oxide (decylamine oxide, cocoamine oxide, myristoylamine oxide, palmitoylamine oxide, alkyldimethylamine oxide Amphoteric surfactants such as alkylamidopropylamine oxide), natural surfactants (lecithin, sodium caseinate, sphingolipid, saponin, mannosyl polyhydric alcohol fatty acid ester, glucosyl polyhydric alcohol fatty acid ester, galactosyl polyhydric alcohol fatty acid) Ester monosaccharide polyhydric alcohol fatty acid ester or disaccharide polyhydric alcohol fatty acid ester, oligosaccharide polyhydric alcohol fatty acid ester, etc.) and amino acid surfactants (capric acid chloride, lauric acid chloride, myristic acid chloride, palmitic acid chloride) , Stearic acid chloride, oleic acid chloride, behenic acid chloride, coconut oil fatty acid chloride and other fatty acid chlorides and glycine, sarcosine, β-alanine, N-methyl-β-alanine, taurine, N-methyl Reaction products with amino acids such as urine), silicone surfactants (silicon KF-6011 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6012 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6013 (manufactured by Shin-Etsu Chemical Co., Ltd.) ), KF-6015 (Shin-Etsu Chemical Co., Ltd.), KF-6016 (Shin-Etsu Chemical Co., Ltd.), KF-6017 (Shin-Etsu Chemical Co., Ltd.), X-22-4991 (Shin-Etsu Chemical Co., Ltd.), NUC Silicon Polyoxyalkylene-modified organopolysiloxanes such as L7002 (Nippon Unicar), SH-3772C (Toray Dow Corning Silicone), SH-3775C (Toray Dow Corning Silicone), ABIL EM-90 (Gold Schmidt) ), ABIL B9806 (manufactured by Goldschmidt), silicone KF-6026 (manufactured by Shin-Etsu Chemical Co., Ltd.), etc., long-chain alkyl-containing polyoxyalkylene-modified organopolysiloxane), polyether-modified silicone (polyoxyethylene, methylpoly) Siloxane copolymer, poly (oxyethylene Xylpropylene) methylpolysiloxane copolymer), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivative, dimethylpolysiloxane, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alcohol-modified silicone, Alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, ammonium-modified polymer silicone, organopolysiloxane, methylphenylpolysiloxane, polysiloxane, poly (N-acylalkylenimine) -modified silicone, dimethylpolysiloxane, nitrogen-containing acrylic-silicone -Based graft copolymer, decamethylcyclopentasiloxane, fluorine-substituted alkyl-modified silicone, organopolysiloxane Le silylalkyl-modified silicone, tricyclic Jiteru Bae Nkarubon acid-modified silicone, trifluoroalkyl-modified silicone
, Divinylpolydimethylsiloxane, dihydrogenpolydimethylsiloxane, dihydrogenpolydimethylsiloxane divinylpolydimethylsiloxane polymer, trimethylsiloxysilicic acid, polyoxypropylene / methylpolysiloxane copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, ethyl Phenyl polysiloxane, octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenyltetracyclosiloxane, polyether-modified polysiloxane, amino-modified polysiloxane, epoxy-modified polysiloxane, fluorine-modified polysiloxane , Alcohol-modified polysiloxane, alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laurylmethyl Ncopolyol, aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, silicone compounds such as eugenol-modified silicone, selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, quinine hydrochloride, strong ammonia water, etc. Examples include hair treatment agents.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clustering, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

(Production Example 1)
The dried material of the root of Inuraracemososa and the whole plant of senshinren is pulverized, and 100 g of each is heated and extracted with purified water (about 30 ° C.) for about 5 hours, filtered and extracted (dry solid content: Inuraracemososa about 0.1-2.5 %, Sensinren about 0.1-3.0%).

(Production Example 2)
The dried product of Inura racemosa rhizome and sensinren whole plant is pulverized, and 100 g each is heated and extracted with purified water (about 80 ° C.) for about 5 hours, filtered and extracted (dry solid content: Inura racemosa about 0.1 to 2.5). %, Sensinren about 0.1-3.0%).

(Production Example 3)
The dried product of Inararacemossa rhizome and sensynlen whole plant is pulverized, each 100 g is soaked in 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to extract (dry solid content: Inularacemososa about 0.1-2.5 %, Sensinren about 0.1-3.0%).

(Production Example 4)
The dried product of Inararacemosa rhizome and sensinren whole plant is pulverized, and 100 g each is immersed in 50% 1,3-butylene glycol solution, extracted at room temperature for 5 days and nights, filtered and extracted (dry solids: About 1.0 kg of Inura racemosa (about 0.1 to 2.5%, sensinren about 0.1 to 3.0%) is obtained.

(Production Example 5)
The dried product of Inura racemosa rhizome and sensinren whole plant is pulverized, each 100 g is soaked in 50% propylene glycol solution, extracted at room temperature for 5 days and nights, and then filtered to extract (dry solid content: Inura racemosa approximately 0.1- About 1.0 kg of 2.5%, sensinren about 0.1-3.0%) is obtained.

(Test 1) Melanin production inhibitory action test The present inventors decided to evaluate the melanin production inhibitory action based on B16 melanoma cells.

“Test method and evaluation method” B16 melanoma cells pre-cultured for 24 hours are transferred to a fresh medium, to which 0.5% of a sample is added and cultured for 2 days. Next, the cultured cells are treated with trypsin, heated and dissolved in 1N-NaOH, 10% DMSO solution, and the absorbance at 420 nm is measured. In addition, distilled water was used as a blank instead of the sample, and the activity of the cells to which the sample was added at the same time was measured by the MTT reduction method (Tim Mosmann; Journal of Immunological Methods p55-63 (1983)). The MTT reduction activity of the sample-loaded cells was calculated using the MTT reduction activity of the cells as 1 unit. The amount of melanin in the sample was calculated as absorbance / MTT reducing activity (1 unit), and the inhibition rate (%) with respect to the amount of melanin produced by blank cells was determined by Equation 1. The results are shown in FIG. The results were tested 4 times for each sample.
Expressed as an average value.
“Sample” As a sample for the melanin production inhibitory action test, the extract obtained in Production Example 3 of the present invention (solid content concentration: adjusted to 50 ppm) was used for the test. As a comparative sample, arbutin (manufactured by Sigma) was prepared under the same conditions and used in the test.

[Equation 1]
Melanin production inhibition rate (%) = {1- (sample melanin amount / blank melanin amount)} × 100

(Test results)
As a result, as shown in FIG. 1, it was confirmed that one or more plant extracts selected from Inula racemosa and sensinren according to the present invention have a very high melanin production inhibitory action with significantly reduced production of melanin pigment. In addition, it is confirmed that the extract of Inularacemososa or sensynlensa has a melanin production inhibitory action of 5 times or more, and can be effectively used as a whitening agent, compared with the whitening agent used very often: arbutin.

(Test 2) Safety test (1) Skin primary irritation test Each plant extract obtained in Production Examples 1 to 5 is prepared with purified water so that the dry solid content concentration is about 0.5 W / V%. The skin of Japanese white rabbits (female, 3 animals per group, body weight around 2.3 kg) with shaved back was applied. Judgment was performed 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indicators. The results were negative in all animals without any erythema or edema.

(Test 3) Safety test (2) Cumulative skin irritation test Similarly, each plant extract obtained in Production Examples 1 to 5 was purified water so that the dry solid concentration would be about 0.5 W / V%. 0.5 ml / animal was applied once a day, 5 times a week to the skin of a Hartley guinea pig (female, 3 mice per group, body weight around 320 g) prepared by shaving the flank. Application was performed over 2 weeks and shaving was performed on the last application day of each week. Judgment was performed on the day after each application date and the day after the last application date by the primary irritation scoring method using erythema and edema as indices. The results were negative in all animals without any erythema or edema over 2 weeks.

(Test 4) Safety test (3) Acute toxicity test Similarly, powder obtained by concentrating and drying each plant extract obtained in Production Examples 1 to 5 under reduced pressure (dry solid content: about 1.0 W / V%) Was orally administered to ddy mice (male and female, 5 mice per group, 5 weeks of age) fasted for 4 hours before the test, and the onset, degree, etc. of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and no abnormalities were found in the results of dissection. Therefore, LD50 was determined to be 2,000 mg / kg or more.

(Prescription Example) Production of Cosmetic Composition, Whitening Cosmetic (Melanin Production Inhibitor, Whitening Agent) Various dosage forms according to the present invention were produced. The prescription example is shown below, but each prescription example may be produced by a conventional method in the production of each product, and only the blending amount is shown. The present invention is not limited to these.

(Formulation Example 1) Emulsion
weight%
1.Squalane 5.0
2.Olive oil 5.0
3. Jojoba oil 5.0
4.Cetanol 1.5
5. Glycerin monostearate 2.0
6.Polyoxyethylene (20) cetyl ether 3.0
7. Polyoxyethylene (20) sorbitan monooleate 2.0
8.1,3-Butylene glycol 1.0
9.Glycerin 2.0
10.Sodium malate 1.0
11. A: Sensinlen extract of Production Example 3 B: Inuraracemossa extract of Production Example 3 * Extract of any one of A to B 5.0
12. Preservative (paraoxybenzoic acid ester) appropriate amount
13.Perfume appropriate amount
14.Purified water residue

(Prescription Example 2) Whitening emulsion
weight%
1. Squalane 8.0
2. Jojoba oil 7.0
3.Cetyl alcohol 2.0
4.Glycerin monostearate 2.0
5.Polyoxyethylene (20) cetyl ether 3.0
6.1,3-Butylene glycol 1.0
7.Glycerin 1.0
8. A: Sensinlen extract of Production Example 3 B: Inuraracemossa extract of Production Example 3 * Extract of any one of A to B 5.0
9. Preservative (methyl paraoxybenzoate) appropriate amount
10. Residue with 100 purified water

(Prescription Example 3) Whitening cream
weight%
1.Squalane 10.0
2.liquid paraffin 10.0
3.Stearic acid 2.0
3.Cetanol 3.0
4.Dimethylpolysiloxane 1.0
5.Cholesterol 0.5
6. Vaseline 2.0
7.Dipropylene glycol 3.0
8.Glycerol monostearate2.0
9.Glycerin 5.0
10. A: Sensinlen extract of Production Example 2 B: Inula racemosa extract of Production Example 2 * Extract of any one of A to B 5.0
11.Azulene 0.2
12. Preservative (Isopropylmethylphenol)
13. Residue with 100 purified water

(Formulation example 4) Cosmetic oil
weight%
1.liquid paraffin 30.0
2.Squalane 20.0
3.Olive oil 20.0
4.Isopropyl palmitate 10.0
5. Sensinlen extract from Production Example 1 1.0
6. Toki hot water extract 1.0
7. Bitter hot water extract 1.0
8.Butylhydroxyanisole 0.1
9. Preservative (Benzalkonium chloride) appropriate amount
10.Perfume appropriate amount
11. Residue with 100 purified water

(Formulation Example 4) Flexible lotion
weight%
1.Glycerin 5.0
2.1,3-Butylene glycol 5.0
3.Polyoxyethylene sorbitan monolaurate (20E.O) 1.0
4.Ethanol 15.0
5. Inula racemosa extract from Production Example 3 1.0
6. Barbasco 30% ethanol extract 1.0
7. Chlorella 30% ethanol extract 1.0
8. Antibacterial and antiseptic (thiamin lauryl sulfate) appropriate amount
9.Perfume appropriate amount
10. Residue with 100 purified water

(Formulation Example 5) Astringent lotion for whitening
weight%
1.Sorbit 2.0
2. POE (20) oleyl alcohol 1.0
3.Ethanol 15.0
4. Sensinlen extract of Production Example 4 2.0
5. Gentian 50% 1,3-butylene glycol extract 2.0
6. Green tea 50% ethanol extract 1.0
7. Hamelis 50% ethanol extract 1.0
8.Allantoin 0.2
9. Astringent (Zinc Sulfocolate) 0.2
10. Antibacterial and antiseptic (butyl paraoxybenzoate) appropriate amount
11.Perfume appropriate amount
12.Residue with 100 purified water

(Formulation Example 6) Carmine lotion (liquid to solid)
weight%
1.Glycerin 3.0
2.1,3-Butylene glycol 5.0
3.Ethanol 15.0
4. Iron oxide (Bengara) 0.2
5.Zinc oxide 0.5
6.Kaolin 2.0
7. Inula racemosa extract of Production Example 5 2.0
8. Eggplant 50% propylene glycol extract 1.0
9. Lemongrass 30% propylene glycol extract 2.0
10. Chen 50% propylene glycol extract 1.0
11.Camphor 0.2
12.Phenol 0.03
13. Preservative (photosensitive element 201) appropriate amount
14.Perfume appropriate amount
15. Residue with 100 purified water

(Prescription Example 7) Pack
weight%
1.Polyvinyl alcohol 15.0
2.Carboxymethylcellulose sodium 5.0
3.Propylene glycol 3.0
4.Ethanol 10.0
Inulin racemosa 50% 1,2-butylene glycol extract 1.0
6. Lemongrass 50% propylene glycol extract 1.0
7. Savonso 50% ethanol extract 1.0
8. Seaweed 50% ethanol extract 1.0
9. Preservative (butyl paraoxybenzoate) appropriate amount
10.Perfume appropriate amount
11. Residue with 100 purified water

(Prescription Example 8) Gel beauty serum for whitening
weight%
1.Xanthan gum 0.4
2.Hydroxyethyl cellulose 0.2
3.Carboxyvinyl polymer 0.2
4.Potassium hydroxide 0.025
5.1,3-Butylene glycol 5.0
6. Sensinlen 60% 1,3-butylene glycol extract 1.0
7. Orange 50% 1,3-butylene glycol extract 1.0
8.Dipotassium glycyrrhizinate 0.2
9. Preservative (methyl paraoxybenzoate) appropriate amount
10.Perfume appropriate amount
11. Residue with 100 purified water

(Formulation example 9) Sunscreen cosmetics
weight%
1.Oxybenzone 2.0
2.Octyl paramethoxycinnamate 5.0
3.Squalane 10.0
4.Vaseline 5.0
5. Stearyl alcohol 3.0
6.Stearic acid 3.0
7. Glyceryl monostearate 2.0
8.Polyethyl acrylate 1.0
9.1,3-Butylene glycol 6.0
10.Edetate disodium 0.1
11.Triethanolamine 1.0
12.Titanium dioxide 5.0
13. Inura racemosa 50% dipropylene glycol extract 0.5
14. Peony skin 50% dipropylene glycol extract 0.5
15. Preservative (paraoxybenzoic acid ester) appropriate amount
16.Perfume appropriate amount
17.Residue with 100 purified water

(Formulation Example 10) Cream Foundation
weight%
1.Stearic acid 4.0
2.Glycerol monostearate3.0
3.Cetanol 1.5
4.Isopropyl myristate 7.0
5. Liquid paraffin 10.0
6. Sarah Beeswax 3.0
7.Triethanolamine 1.5
8.Glycerin 3.0
9. Bentonite 1.0
10.Titanium oxide 8.0
11.Kaolin 3.0
12.Talc 3.0
13. Color pigment (yellow iron oxide) 1.0
14.Sensinlene 70% ethylene glycol extracted dry powder 0.1
15. Ogon 70% ethylene glycol extracted dry powder 0.1
16. Preservative (ethyl parahydroxybenzoate) appropriate amount
17.Perfume appropriate amount
18.Residual water 100

(Prescription Example 11) Liquid Foundation
weight%
1.Octamethylcyclotetrasiloxane 20.0
2.Polyoxyethylene oleyl ether 4.0
3.Polyoxyethylene hydrogenated castor oil 3.0
4.Aluminum monostearate 0.01
5.Sodium glutamate 1.5
6. Liquid paraffin 12.0
7.Dimethylpolysiloxane 5.0
8.12-Hydroxystearic acid 1.0
9. Titanium oxide 4.0
10.Sorbitol 7.0
11. Color pigment (yellow iron oxide) 1.0
12. Sensinlen 70% ethanol extracted dry powder 0.1
13. Pruned 70% ethanol extracted dry powder 0.1
14. Preservative (Chlorhexidine) Appropriate amount
15.Perfume appropriate amount
16.Residue with 100 purified water

(Prescription Example 12) Powder Foundation
weight%
1.Zinc stearate 3.0
2.Nylon powder 11.0
3.Methylpolysiloxane 3.0
4.Isononyl isononanoate 2.0
5. Liquid paraffin 2.0
6. Octyldodecanol 1.0
7. Colored pigment (yellow iron oxide) 1.0
8. Coloring pigment (Bengara) 1.0
9.Sensinlene 70% ethylene glycol extracted dry powder 0.1
10.Silicone-treated sericite 40.0
11.Silicone-treated mica 8.0
12.Silicone-treated fine particle titanium oxide 5.0
13. Residue with silicone treated talc 100
14. Preservative (Isopropyl methyl ether)

(Prescription Example 13) Eyeliner
weight%
1. Alkyl acrylate copolymer emulsion 30.0
2.1,3-Butylene glycol 15.0
3. Coloring pigment (black iron oxide) 15.0
4. Acrylic acid / alkyl methacrylate copolymer 0.1
5.Sodium hydroxide 0.05
6.Carboxymethylcellulose sodium 2.0
7. Inula racemosa 70% ethanol extracted dry powder 0.1
8. Preservative (paraoxybenzoic acid ester) appropriate amount
9. Residue with 100 purified water

(Prescription Example 14) Styling Gel
weight%
1.Carboxyvinyl polymer 0.1
2. Acrylic acid / alkyl methacrylate copolymer 0.1
3.Sodium hydroxide 0.08
4.Vinyl pyrrolidone / vinyl acetate copolymer solution 10.0
5.Sodium hydroxide 0.05
6. Sodium pyrrolidonecarboxylate 0.1
7.Sensinlene 70% 1,3-butyleneglycol extracted dry powder 0.1
8. Preservative (butyl paraoxybenzoate) appropriate amount
9. Residue with 100 purified water

(Prescription Example 15) Shampoo
weight%
1.Lauryl sulfate triethanolamine 5.0
2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.1,3-Butylene glycol 4.0
4.Lauric acid diethanolamide 2.0
5. Edetate disodium 0.1
6. Inuraracemossa 30% 1,2-butylene glycol extract 2.0
7. Sensinlen 30% 1,2-butylene glycol extract 2.0
8. Diou 30% 1,2-butylene glycol extract 2.0
9. Ginger 30% 1,2-butylene glycol extract 1.0
10.Tannic acid aqueous solution 2.0
11. Hydrolyzed silk solution 1.0
12. Antibacterial / preservative (thiamin lauryl sulfate) appropriate amount
13.pH adjuster
14.Perfume appropriate amount
15. Residue with 100 purified water

(Formulation Example 16) Rinse
weight%
1. Stearyltrimethylammonium chloride 2.0
2.Cetostearyl alcohol 2.0
3.Polyoxyethylene lanolin ether 3.0
4.Propylene glycol 5.0
Inulin racemosa 50% 2,3-butylene glycol extract 1.0
6. Sensinlen 50% 2,3-butylene glycol extract 1.0
7. Altea 50% 2,3-butylene glycol extract 1.0
8. Trehalose solution 1.0
9. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
10.Perfume appropriate amount
11. Residue with 100 purified water

(Prescription Example 17) Hair Liquid
weight%
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0
4.Triethanolamine 1.0
5.Trimethylene glycol 5.0
6. Sensinlen 50% propylene glycol extract 1.0
7. Seaweed 50% ethanol extract 1.0
8.Azulene 1.0
9. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
10. Fragrance (camomile water) appropriate amount
11. Residue with 100 purified water

(Prescription Example 18) Hair Nick
weight%
1.Ethanol 40.0
2.Ethyl oleate 1.0
3.Polyoxyethylene (40) hydrogenated castor oil 2.0
4.A: Sensinlen extract of Production Example 2 B: Inulalacemosa extract of Production Example 2 * Extract of any one of A to B 5.0
5. Comfrey 60% ethanol extract 3.0
6. Preservative (ethyl paraoxybenzoate) appropriate amount
7.Perfume appropriate amount
8. Residue with 100 purified water

(Formulation example 19) Hair growth / hair growth agent
weight%
1.Ethanol 60.0
2.Sensinlene 70% propylene glycol extract 5.0
3. 枇杷 70% propylene glycol extract 1.0
4. Vitamin E derivative 0.5
5.Resorcin 0.5
6.Glycyrrhizic acid 0.5
7.Hydroxypropyl chitosan solution 0.5
8.Bovine hematin solution 0.5
9.Mucin solution 0.5
10. Amino acids (Glycine, Glutamine, etc.) 0.5
11. Antibacterial and antiseptic (butyl paraoxybenzoate) 0.1
12.Perfume appropriate amount
13. Residue with 100 purified water

(Formulation example 20) Coating protective agent (melanin production inhibitor, whitening agent)
A gauze or liniment cloth is impregnated with a prescription solution in which appropriate amounts of sensinren hot water extract, antibiotics, anti-inflammatory, etc. are mixed, and attached to the wound. Alternatively, the sensinren extract may be directly applied locally and covered with gauze or the like.

(Test 5) Use effect test The effect at the time of actually using the cosmetic composition of this invention was examined. The use test is a panel for 20 people aged 30 to 60 years old who are suffering from dry skin, no gloss, no firm skin, and every day, twice a day in the morning and after the face wash, the appropriate amount of the prescription example 1 emulsion on the face for 3 months It was carried out by coating over the whole area. In addition, the thing which remove | excluded each plant extract of this invention from the emulsion by the same method was used for the control. The evaluation method is based on the following criteria, and the results are as shown in Table 1. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.

"Skin feel improvement effect"
Effective: Improved dry skin, gloss and firmness of the skin, and improved skin.
Slightly effective: Slightly increased dry skin and skin gloss and tension, and improved skin.
Invalid: No change before use.

(Test results)
As shown in Table 1, it is confirmed that the emulsion containing the plant extracts of Inularacemososa and Sensinren of the present invention increases dry skin and gloss and tension of the skin, improving the skin, and prevents aging of the skin and scalp. It is valid.

(Test 6) Use effect test The effect when the whitening cosmetic of the present invention was actually used was examined. The use test was conducted by 20 women aged 50 to 50 years old suffering from stains, buckwheat, and dark-skinned, each day, twice a day in the morning and at night, after the face wash, the appropriate amount of the whitening emulsion of Prescription Example 2 on the face for 3 months This was done by coating across. In addition, the thing which remove | excluded each plant extract of this invention from the whitening emulsion was prescribed | regulated by the same method as the control. The evaluation method is based on the following criteria, and the results are as shown in Table 2. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.

“Blemish / Sobacus & Skin Color Improvement”
Effective: Blemish and freckles and skin color are white and reduced.
Slightly effective: white spots and skin color are white and slightly reduced.
Invalid: No change before use.

(Test results)
As shown in Table 2, the whitening emulsion containing the plant extracts of Inula racemosa and sensinren according to the present invention can significantly improve spots and freckles and whiten the skin color and can be used as a whitening agent. .

It is a figure which shows the suppression rate with respect to the melanin production amount of each plant extract of Inula racemosa of the present invention and sensinren.

Claims (4)

  A melanin production inhibitor comprising, as an active ingredient, one or more plant extracts selected from Inula racemosa and sensinren.   A whitening agent comprising the melanin production inhibitor according to claim 1.   A cosmetic composition comprising, as an active ingredient, one or more plant extracts selected from Inula racemosa and sensinren.   A cosmetic for whitening comprising one or more plant extracts selected from Inurarasemosa and Senshinren as an active ingredient.