JP2016088882A - External preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external preparation that improves the duration of cooling effect and also improves its moisture retention feeling.SOLUTION: The present invention provides an external preparation comprising (A) menthol or a derivative thereof, (B) diglycerol, (C) an acrylic acid polymer, and at least one selected from (D) tranexamic acid or a derivative thereof, and ascorbic acid glucoside.SELECTED DRAWING: None

Description

  The present invention relates to an external preparation.

  Generally, in order to obtain an external preparation having a high cooling effect, a component having a cooling effect such as menthol is used. In order to enhance the cooling effect, for example, the enhancement of the cooling effect has been disclosed by adding agar with a specific hardness and a water-soluble polymer, but the cooling effect was not sufficient.

JP-A-11-209262

  The present inventor added an acrylic polymer that is expected to enhance the cooling effect because diglycerin was added to menthol, but the cooling effect was reduced, and the moisturizing feeling of the external preparation was further reduced. Found that the decline. As a result of aiming to maintain the cooling effect and improve the moisturizing feeling, it was found that the addition of tranexamic acid or ascorbic acid glucoside to the aforementioned three components improves the cooling effect and moisturizing feeling.

  The present invention has been made in view of the above circumstances. By adding tranexamic acid or ascorbic acid glucoside to menthol, diglycerin and acrylic polymer, the menthol has a sustained cooling effect and a moisturizing feeling of an external preparation. The purpose is to provide an external preparation with improved quality.

  As a result of intensive studies to solve the above problems, the present inventors have further included tranexamic acid or ascorbic acid glucoside in an external preparation containing menthol, diglycerin, and acrylic acid-based polymer. It has been found that the moisture retention of external preparations can be improved. The present invention is based on these findings.

That is, the present invention relates to the following [1] to [4], for example.
[1] Contains at least one selected from (A) menthol or derivatives thereof, (B) diglycerin, (C) acrylic acid polymer, and (D) tranexamic acid or derivatives thereof, and ascorbic acid glucoside. , External preparation.
[2] The external preparation described in [1], which is for maintaining a cooling effect.
[3] 0.001 to 5% by weight of (A) menthol or a derivative thereof, 0.01 to 20% by weight of (B) diglycerin, and 0.01 to 5% by weight of (C) acrylic acid polymer. And (D) one or more selected from tranexamic acid or its derivatives and ascorbic acid glucoside in an amount of 0.001 to 10 times, the external preparation according to [1] to [2].
[4] (C) The acrylic polymer is at least one selected from carboxyvinyl polymer, alkyl acrylate copolymer, acrylic acid / alkyl methacrylate copolymer, polyacrylic acid, polyvinyl alcohol, and polyvinylpyrrolidone. ]-The external preparation as described in [3].

  ADVANTAGE OF THE INVENTION According to this invention, it becomes possible to provide the external preparation which maintained the cooling effect of menthol and improved the moisturizing feeling of the external preparation.

  Hereinafter, a mode for carrying out the present invention (hereinafter referred to as “the present embodiment”) will be described in detail. In addition, this invention is not limited to the following embodiment.

  The external preparation of this embodiment is selected from (A) menthol or a derivative thereof, (B) diglycerin, (C) an acrylic acid polymer, and (D) tranexamic acid or a derivative thereof, and ascorbic acid glucoside. Contains one or more.

(A) Menthol or its derivative Menthol or its derivative includes l-menthol, dl-menthol, menthoxypropanediol, monomenthyl glyceryl ether, menthyl lactate and the like. It may be synthesized by a known method or obtained as a commercial product. Mentha oil containing menthol, mint mint oil, spearmint oil can also be used.

Menthol or its derivative may be used individually by 1 type, and may be used in combination of 2 or more type.

Content of (A) component in the external preparation of this embodiment is 0.001-5 weight% on the basis of the whole quantity of external preparation, 0.01-3 weight% is preferable, 0.1-2 weight % Is more preferable. If content of (A) component is the said range, sufficient cooling sustained effect will be acquired.

(B) Diglycerin Diglycerin is a polyhydric alcohol having a moisturizing effect. It may be synthesized by a known method or can be obtained as a commercial product.

Content of (B) component in the external preparation of this embodiment is 0.01-20 weight% on the basis of the whole quantity of external preparation, 0.1-10 weight% is preferable, 0.5-5 weight % Is more preferable. If content of (B) component is the said range, sufficient cooling continuation effect and a moisturizing feeling will be acquired.

(C) Acrylic acid polymer As the acrylic acid polymer, any polymer that can be generally used may be used. For example, carboxy such as BF Goodrich's Carbopol (trade name) or 3VSSigma's sinter (trade name). Vinyl polymers, alkyl acrylate copolymers such as Noveon's Carbopol AQUA SF-1 (trade name), BF Goodrich's PEMULEN (trade name) and other acrylic acid / methacrylic acid copolymers, Aronbis AH-105 from Nippon Shokubai Co., Ltd. (Trade name) such as polyacrylic acid, polyvinyl alcohol, polyvinylpyrrolidone and the like.

The acrylic acid polymer can also be used as a pharmaceutically acceptable salt, for example, a salt with an organic base (for example, a trimethylamine salt, a triethylamine salt, a monoethanolamine salt, a triethanolamine salt, a pyridine salt, etc. Salts with tertiary amines, basic ammonium salts such as arginine), salts with inorganic bases (for example, alkali metal salts such as ammonium, sodium and potassium salts, alkaline earth such as calcium and magnesium salts) Metal salts, aluminum salts and the like), and particularly preferable salts are sodium salt, potassium salt, triethanolamine salt, and arginine salt.

Content of (C) component in the external preparation of this embodiment is 0.01-5 weight% on the basis of the whole quantity of external preparation, 0.05-3 weight% is preferable, 0.1-1 weight % Is more preferable. If content of (C) component is the said range, sufficient cooling continuous effect and a moisturizing feeling will be acquired.

(D) Tranexamic acid or a derivative thereof Tranexamic acid is a compound known as an anti-inflammatory agent or a whitening agent. Examples of the derivatives include cetyl tranexamic acid, methyl amide of tranexamic acid, ethyl amide of tranexamic acid and the like. It may be synthesized by a known method or obtained as a commercial product.

  Tranexamic acid or a derivative thereof may be used as a salt thereof. The salt is not particularly limited as long as it is a pharmacologically (pharmaceutically) or physiologically acceptable salt as an external preparation. Examples of salts of tranexamic acid include alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt and magnesium salt; zinc salt; iron salt; ammonium salt; arginine, lysine, histidine, ornithine and the like. And salts with amines such as monoethanolamine, diethanolamine, and triethanolamine. As the salt of tranexamic acid, among them, sodium salt, potassium salt, triethanolamine salt and arginine salt are preferable, and sodium salt is more preferable.

  One kind of tranexamic acid or a derivative thereof may be used alone, or two or more kinds thereof may be used in combination.

  From the viewpoint of further enhancing the effects of the present invention, the content of (D) tranexamic acid or a derivative thereof in the external preparation of the present embodiment is, for example, the total content of tranexamic acid or a derivative thereof based on the total amount of the external preparation. The amount is usually 0.1 to 5% by weight, preferably 0.5 to 3% by weight, and more preferably 0.8 to 2.2% by weight. If the content of tranexamic acid or a derivative thereof is in the above range, in addition to the effects of the present invention, the effects of tranexamic acid or a derivative thereof such as whitening, anti-inflammation, and improvement of rough skin can be obtained.

(D) Ascorbic acid glucoside Ascorbic acid glucoside is a glycoside of ascorbic acid and is a compound known as a whitening agent. It may be synthesized by a known method or obtained as a commercial product.

  The content of ascorbic acid glucoside (D) in the external preparation of this embodiment is, for example, from the viewpoint of further enhancing the effect of the present invention, for example, the content is usually 0.001 to 0.001 based on the total amount of the external preparation. 5 wt%, preferably 0.005 to 5 wt%, more preferably 0.01 to 3 wt%, and even more preferably 0.05 to 3 wt%. If content of ascorbic acid glucoside is the said range, in addition to the effect by this invention, effects, such as whitening and rough skin improvement which ascorbic acid glucoside has, can be acquired.

  From the viewpoint of further enhancing the effect of the present invention, the total content of the component (D) in the external preparation of the present embodiment is, for example, usually 0.001 to 10% by weight on the basis of the total amount of the external preparation. It is preferable that it is 0.005 to 7 weight%, and it is more preferable that it is 0.01 to 5 weight%. When the total content of the component (D) is in the above range, in addition to the effects of the present invention, actions such as whitening, anti-inflammation, and rough skin improvement that the component (D) has can be obtained.

  The external preparation of this embodiment may be any of pharmaceuticals, quasi drugs, and cosmetics. The external preparation of the present embodiment is preferably a skin external preparation applied to the skin and scalp because it has an appropriate viscosity and is excellent in the feeling of use.

  The form of the external preparation of this embodiment used for pharmaceuticals is not particularly limited, and examples thereof include solutions, suspensions, emulsions, creams, ointments, gels, liniments, lotions, and aerosols. . These preparations can be manufactured according to the method described in the 16th revised Japanese Pharmacopoeia General Rules for Preparations. As a form of external preparation, a liquid agent, a suspension agent, an emulsion, a cream agent, an ointment, a gel agent, a lotion agent, and an aerosol agent are preferable, and a liquid agent, a gel agent, and an aerosol agent are more preferable.

  Also when it is set as the external preparation used for quasi-drugs or cosmetics, it can be made into the same form as said external preparation for pharmaceuticals. In addition, the form of the external preparation includes a stick agent, a sheet agent obtained by impregnating a non-woven fabric with a chemical solution, and the like. As a form of the external preparation used for quasi-drugs or cosmetics, among them, a liquid agent, a gel agent, a sheet agent, and an aerosol agent are preferable.

  The external preparation of this embodiment may be solubilized or emulsified, but is preferably solubilized. The solubilized product is more likely to feel a cooling feeling.

  It is preferable that the external preparation of this embodiment is a transparent formulation. The transparent preparation means that when the preparation is put in a transparent glass screw mouth bottle having a diameter of about 4 cm, the letter “A” of 5 mm square can be clearly discriminated through the side surface of the glass screw mouth bottle.

  Examples of uses in the case of quasi-drugs or external preparations for cosmetics include, for example, lotions, emulsions, creams, gels, serums, sunscreen cosmetics, packs, masks, hand creams, body lotions, body creams Basic cosmetics such as facial cleansers, makeup removers, shaving agents, body shampoos, shampoos, rinses, treatments, etc .; lip cosmetics such as lip balms and lipsticks, foundations, and makeup makeup such as mascara Hair removal agent; bath agent and the like.

  In addition to the above components, the external preparation of the present embodiment can contain a base or carrier usually used in pharmaceuticals, quasi drugs or cosmetics. Moreover, the external preparation of this embodiment can contain an additive as needed.

  Examples of the base or carrier contained in the external preparation of the present embodiment include hydrocarbons such as liquid paraffin, squalane, petrolatum, ozokerite, and α-olefin oligomers; methyl polysiloxane, cross-linked methyl polysiloxane, and highly polymerized methyl Polysiloxane, Cyclic silicone, Alkyl-modified silicone, Cross-linked alkyl-modified silicone, Amino-modified silicone, Polyether-modified silicone, Polyglycerin-modified silicone, Cross-linked polyether-modified silicone, Cross-linked alkyl polyether-modified silicone, Silicone / alkyl chain copolymer Modified polyether modified silicone, silicone / alkyl chain co-modified polyglycerin modified silicone, polyether modified branched silicone, polyglycerin modified branched silicone, acrylic silicone, phenyl modified Silicone oils such as silicone and silicone resin; higher alcohols such as cetanol, stearyl alcohol and behenyl alcohol; sterols such as cholesterol, phytosterol and phytosteryl hydroxystearate; jojoba oil, meadow foam oil, sunflower oil, grape seed oil, coconut oil, squalane , Vegetable oils such as shea butter and rice germ oil; animal oils such as lanolin, orange luffy oil, squalane and horse oil; natural polymer derivatives such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, cationized guar gum; carrageenan, alginic acid, cellulose , Guar gum, quince seed, dextran, gellan gum and other natural polymers; polyethylene glycol; dioxane; butylene glycol Cole adipate polyester; isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate, jojoba oil, tri (caprylic acid / capric acid) glyceryl, etc. Esters; polysaccharides such as dextrin and maltodextrin; lower alcohols such as ethanol and isopropanol; polyhydric alcohols having 2 to 6 carbon atoms and 2 to 4 hydroxyl groups; glycol ethers; succinic acid, glycolic acid, gluconic acid, citric acid And organic bases such as water; and water-based bases such as water. The base or carrier contained in the external preparation of the present embodiment is preferably a polyhydric alcohol.

  Preferable examples of the external preparation of the present embodiment include a liquid agent containing a polyhydric alcohol as a base, a suspension agent, and a gel agent.

  As the base or carrier, one kind may be used alone, or two or more kinds may be used in combination.

  In the external preparation of the present embodiment, known additives that are added to pharmaceuticals, quasi drugs, or cosmetics, for example, antioxidants, surfactants, thickeners, as long as the effects of the present invention are not impaired. Preservatives, pH adjusters, stabilizers, irritation reducers, preservatives, colorants, cooling agents, fragrances, pearl luster imparting agents, and the like can be added.

  Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, sodium pyrosulfite, ascorbic acid, ascorbic acid derivative, tocopherol, tocopherol derivative, erythorbic acid, L-cysteine hydrochloride and the like. .

  Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate. Sorbitan fatty acid esters of propylene glycol fatty acid esters such as propylene glycol monostearate; polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hardened Hardened castor oil derivatives such as castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80; polyoxyethylene (20) sorbitan (polysorbate 20) monolaurate, monoste Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene phosphate (20) sorbitan (polysorbate 60), polyoxyethylene monooleate (20) sorbitan (polysorbate 80), polyoxyethylene (20) sorbitan isostearate; polyoxy Glyceryl alkyl ether; alkyl glucoside such as cetostearyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether and polyoxyethylene behenyl ether; amines such as stearylamine and oleylamine; polyoxyethylene -Methyl polysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxy Silicone surfactants such as tildimethicone; natural surfactants such as phospholipids, surfactin, and saponins; fatty acid amide amines such as diethylaminoethylamide stearate and diethylaminopropyl stearate; trilaurylamine, dimethylstearylamine, di Alkylamines such as 2-ethylhexylamine; betaine amphoteric surfactants such as dimethylaminopropylamide stearate and laurylhydroxysulfobetaine;

  Examples of the thickener include guar gum, locust bean gum, carrageenan, xanthan gum, polyethylene glycol, bentonite, alginic acid, macrogol, sodium chondroitin sulfate, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, Cellulosic thickeners such as carboxymethyl cellulose and carboxyethyl cellulose are listed.

  Examples of preservatives or preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxybenzoate Examples include benzyl benzoate, methyl paraoxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorhexidine gluconate, alkanediol, and glycerin fatty acid ester.

  Examples of the stabilizer include dibutylhydroxytoluene and butylhydroxyanisole.

  Examples of the irritation reducing agent include licorice extract, sodium alginate, 2-methacryloyloxyethyl phosphorylcholine, and the like.

  Examples of the chelating agent include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetic acid salt (sodium salt (sodium edetate: Japanese Pharmacopoeia, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, polyphosphorus An acid, metaphosphoric acid, etc. are mentioned. Among them, sodium edetate is preferable as the chelating agent.

  Examples of the colorant include inorganic pigments and natural pigments.

  Examples of the refreshing agent include camphor and eugenol.

  Examples of the pearl luster imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate. Among these, as the pearly luster imparting agent, ethylene glycol distearate is preferable.

  An additive may be used individually by 1 type and may be used in combination of 2 or more type.

  The external preparation of this embodiment can contain another active ingredient in the range which does not impair the effect of this invention. Specific examples of active ingredients include, for example, moisturizing ingredients, anti-inflammatory ingredients, antibacterial ingredients, vitamins, peptides or derivatives thereof, amino acids or derivatives thereof, cell activation ingredients, anti-aging ingredients, blood circulation promoting ingredients, keratin softening ingredients, Whitening components, astringent components, UV protection components (UV absorption components, UV scattering components) and the like can be mentioned.

  Examples of moisturizing ingredients include lipids such as ceramide, cholesterol, and phospholipid; plant extract extracts such as chamomile extract, mulberry extract, docami extract, carrot extract, hamamelis extract, bilberry leaf extract, tea extract, hamamelis extract, shrimp extract and perilla extract , Heparin-like substances, and mucopolysaccharides such as chondroitin and sodium chondroitin sulfate, and high molecular compounds such as collagen, elastin, keratin, chitin, and chitosan; glycerin, 1,3-butylene glycol, propylene glycol, polyethylene glycol, and diglycerin Polyhydric alcohols such as trehalose; alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glucosamine, asparagi Amino acids such as acids, theanine, and arginine; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidone carboxylate; sugar alcohols such as sorbitol; phospholipids such as lecithin and hydrogenated lecithin; polyglutamic acid; , LIPIDURE (registered trademark), etc.) polymers having a phospholipid polar group; polyoxypropylene methylglucoside; trimethylglycine (betaine); hydroxyethylurea; acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer It is done. Among these moisturizers, in consideration of the feeling of use, lipids such as ceramide, cholesterol and phospholipid; plant extract extracts such as mulberry extract, dokudami extract, carrot extract, hamamelis extract, yukinoshita extract and bilberry leaf extract are preferable.

  Examples of the anti-inflammatory component include components derived from plants (eg, grapes, ginseng, and comfrey), allantoin, glycyrrhizic acid or derivatives thereof, zinc oxide, pyridoxine hydrochloride, and ε-aminocaproic acid, proanthocyanidins, tocopherols. Or a derivative thereof, ascorbic acid or a derivative thereof, hesperidin, glucosyl hesperidin, ergothioneine, sodium bisulfite, erythorbic acid or a salt thereof, flavonoid, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, Examples include thiotaurine and hypotaurine.

  Antibacterial or bactericidal components include, for example, chlorhexidine, benzalkonium chloride, acrinol, sulfur, resorcin, ethanol, benzethonium chloride, adapalene, benzoyl peroxide, clindamycin, cresol, gluconic acid and its derivatives, popidone iodine, potassium iodide , Iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101, photosensitizer 201, alkane diol such as paraben, phenoxyethanol, 1,2-pentanediol, glycerin fatty acid ester, azelaic acid, alkyldiaminoglycine hydrochloride, glucone Examples include acid chlorhexidine and zinc paraphenol sulfonate.

  Examples of vitamins include vitamin A such as retinol, retinol acetate, retinol palmitate, retinal, retinoic acid, methyl retinoic acid, ethyl retinoic acid, retinol acid retinol, tocopheryl retinoate; carotene, lycopene, zeaxanthin, crypto Provitamin A such as xanthine and echinenone; vitamin E such as tocopherol, tocopherol acetate, tocopherol succinate and tocopherol nicotinate; riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5 '-Vitamin B2 such as sodium phosphate ester, riboflavin tetranicotinate ester; tocopherol nicotinate, Nicotinic acids such as benzyl cotinate and methyl nicotinate; vitamins such as ascorbyl stearate, ascorbyl tetrahexyldecanoate, ascorbic acid, dehydroascorbic acid, ascorbic acid phosphate, ascorbic acid stearate, ascorbyl palmitate C: Vitamin D such as methyl hesperidin, ergocalciferol, cholecalciferol; vitamin K such as phylloquinone, farnoquinone; dibenzoylthiamine, dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiaminecetyl hydrochloride, thiamine thiocyanic acid Salt, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine Vitamin B1 such as min monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, and thiamine triphosphate monophosphate; vitamins such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal phosphate, pyridoxamine hydrochloride B6 types; vitamin B12 types such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin; folic acids such as folic acid and pteroylglutamic acid; nicotinic acids such as nicotinic acid and nicotinamide; pantothenic acid, calcium pantothenate, panthenol, D -Pantothenic acids such as panthetin, coenzyme A, pantothenyl ethyl ether; biotins such as biotin and bioticin; and γ-oryzanol, carnitine, ferulic acid, - lipoic acid, and vitamin-like effect factors such as orotic acid, and the like.

  Peptides or derivatives thereof include, for example, keratin degrading peptide, hydrolyzed keratin, elastin degrading peptide, collagen degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, conchiolin degrading peptide, hydrolyzed conchiolin, silk Examples include proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy proteolytic peptides, hydrolyzed soy protein, casein degrading peptides, and acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.) .

  Examples of amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine. Methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine and the like.

  Examples of the cell activation component include amino acids such as γ-aminobutyric acid and ε-aminoproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids; α- such as glycolic acid and lactic acid. Examples thereof include hydroxy acids; tannins; flavonoids; saponins; allantoins;

  Examples of the anti-aging component include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivative, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone.

  Examples of the blood circulation promoting component include plants (e.g., ginseng, fennel, enamel, Dutch oak, chamomile, roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake, hawthorn, chamomile, cucumber, thyme, thyme, Clove, chimney, spruce, spruce, spruce, carrot, garlic, butcher bloom, grape, button, maronier, melissa, yuzu, yakuinin, rosemary, rosehip, chimpi, touki, spruce, peach, apricot, walnut, or corn) Ingredients derived from: glucosyl hesperidin and the like.

  Examples of the keratin softening component include urea, glycolic acid, gluconic acid, fruit acid, phytic acid, lanolin, lactic acid, citric acid, and sulfur.

  Examples of the whitening component include arbutin; hydroquinone; kojic acid; ellagic acid; phytic acid; lucinol; chamomile ET; ascorbic acid or a derivative thereof; vitamin E or a derivative thereof; pantothenic acid or a derivative thereof; Examples thereof include plant extracts and essential oils).

  Astringent ingredients include, for example, alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc sulfate, zinc paraphenol sulfonate, zinc oxide, and aluminum potassium sulfate; tannic acid, citric acid, lactic acid, succinate Examples include organic acids such as acids, ethanol, and the like.

  Examples of the UV absorbing component include 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4,6-tris [4- (2-ethylhexyl). Oxycarbonyl) anilino] -1,3,5-triazine, 2-ethylhexyl dimethoxybenzylideneoxoimidazolidinepropionate, and 2,4-bis-[{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine, t-butylmethoxydibenzoylmethane, dibenzylidenedioxoimidazolidinepropyrate ethylhexyl, etorhexyltriazoline, paraaminobenzoic acid and its derivatives, para Octyl dimethylaminobenzoate Sachiriru acid ethylene glycol, dihydroxy benzophenone.

  Examples of the ultraviolet scattering component include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, hydrous silicic acid; Compound coated with hydrous silicic acid, aluminum hydroxide, or inorganic powder such as mica or talc; compounded with resin powder such as polyamide, polyethylene, polyester, polystyrene or nylon; and The thing etc. which processed these inorganic compounds with silicone oil, fatty acid aluminum salt, etc. are mentioned.

  Examples of cleaning components include polyoxyalkylene alkyl (or alkenyl) ether sulfates, alkyl (or alkenyl) sulfates, higher fatty acid salts (such as palmitic acid, lauric acid, myristic acid, and stearic acid), ether carboxylates Amide ether carboxylate, alkyl phosphate ester salt, N-acyl amino acid salt (sodium N-lauroyl aspartate, potassium hydroxide / potassium coconut oil fatty acid acyl glutamate, coconut oil fatty acid acyl glycine sodium, myristoyl glutamic acid, etc. ), Anionic surfactants such as polyoxyalkylene fatty acid amide ether sulfate, acylated isethionate, and acylated taurate; linear or branched long chain alkyl groups to which alkylene oxide may be added Cationic surfactants such as mono or di long chain alkyl quaternary ammonium salts; and carbobetaines, sulfobetaines, imidazolinium betaines (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaines, and N -Palm oil fatty acid acyl-N-carboxymethoxyethyl-N-carboxymethylethylenediamine disodium etc.), and amphoteric surfactants such as amide betaine.

  Other active ingredients may be used alone or in combination of two or more.

  The external preparation of this embodiment may be an external preparation packed in a container. Examples of the container shape include a bottle type, a tube type, a jar type, a spoid type, a dispenser type, a pouch bag, and a cheer pack. Examples of the container material include polyethylene terephthalate, polypropylene, polyethylene (such as HDPE, LDPE, and LLDPE), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, and metal (such as aluminum). Considering the strength, flexibility, and weather resistance of these materials, and the stability of the components contained in the containers, the containers containing these materials can be subjected to various coating treatments, or these materials can be mixed, for example. Thus, the container material can be combined to form a container material, or a layer made of these materials can be laminated to form the container material. In addition, those skilled in the art should appropriately select the diameter and material of the nozzle of the container and the discharge part of the preparation in order to adjust the discharge amount of the preparation from the container or reduce the adhesion of the preparation to the container. Can do.

  The method for using the external preparation of the present embodiment varies depending on the skin condition, age, sex, or the like of the subject of use, and examples thereof include the following methods. What is necessary is just to apply | coat an appropriate amount (for example, 0.05-5g) to skin several times a day (for example, 1-5 times, preferably 1-3 times). Moreover, if an external preparation is applied so that the daily use amount of tranexamic acid is, for example, 0.00001 to 0.05 g, preferably 0.0001 to 0.02 g, more preferably 0.0002 to 0.01 g. Good. The application period may be, for example, 1 to 6 months, preferably 3 to 6 months.

The external preparation of the present embodiment is expected to have an effect of suppressing skin irritation due to sunburn, exercise, temperature, etc., giving a cool touch to the skin, and suppressing skin inflammation in anticipation of the physiological activity of menthol. . Similarly, in view of the physiological activity of tranexamic acid or ascorbic acid glucoside, it can be suitably used for people who have skin spots, pore darkening, inflammation and the like. Similarly, a high moisturizing effect is obtained by the effect of diglycerin, and a transparent skin can be obtained. Therefore, it can be suitably used for people having dry skin or sensitive skin.
The external preparation of this embodiment can be used suitably also for the person who has normal skin. In addition, since the external preparation of the present embodiment maintains an appropriate viscosity, it improves the feeling of use, such as cushioning and around the skin, prevents flow-off when picked up by the hand, and the amount of application per time The effect of improvement can also be obtained.

  The external preparation of the present embodiment can be expected to have an effect of making the pores inconspicuous by adding ethanol, further increasing the cooling effect, providing a constricting effect and a converging effect.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated more concretely, this invention is not limited to these Examples.

[Test example: Evaluation of cooling effect and moisturizing effect]
(1) Preparation of test sample The test sample used was prepared by appropriately mixing various reagents at a mixing ratio shown in Table 1. The prepared test sample was transparent.

(2) Test method (use feeling evaluation)
Two male and four female evaluators asked each test sample to evaluate the cooling effect 10 seconds after application and the moisturizing feeling after application in five stages, and the average value was calculated.

(3) Test results The evaluation results are shown in Table 1. When tranexamic acid and ascorbic acid glucoside were added to menthol, diglycerin, and carboxyvinyl polymer, respectively, the cooling effect was enhanced and the moisturizing feeling was also enhanced.

Formulation Example An external preparation is prepared according to the following formulation. In addition, each numerical value of a prescription example shows weight%.

Claims (4)

An external preparation containing at least one selected from (A) menthol or a derivative thereof, (B) diglycerin, (C) an acrylic polymer, and (D) tranexamic acid or a derivative thereof, and ascorbic acid glucoside. . The external preparation according to claim 1, which is for cooling effect maintenance. (A) 0.001 to 5% by weight of menthol or a derivative thereof, (B) 0.01 to 20% by weight of diglycerin, (C) 0.01 to 5% by weight of vinyl polymer, and (D The external preparation according to claim 1 or 2, comprising 0.001 to 5 times of at least one selected from tranexamic acid or a derivative thereof and ascorbic acid glucoside. (C) The acrylic acid polymer is at least one selected from carboxyvinyl polymer, alkyl acrylate copolymer, acrylic acid / alkyl methacrylate copolymer, polyacrylic acid, polyvinyl alcohol, and polyvinylpyrrolidone. The external preparation described in 1.