JP6391927B2 - Skin external composition - Google Patents

Description

  The present invention relates to a composition for external use on skin, which contains a silicone poorly soluble ultraviolet absorber, trimellitic acid ester, modified silicone and / or cyclic silicone, and nonpolar oil.

  As a hardly soluble ultraviolet absorber, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, 4-tert-butyl-4′-methoxy-dibenzoylmethane, etc. Since they have an excellent ultraviolet absorption effect, they are used as raw materials for cosmetics such as sunscreen cosmetics (Non-patent Document 1).

  In order to prevent and dissolve the hardly soluble UV absorber in cosmetics, ester oils that are widely used as dissolving agents for various hardly soluble components are often used.

  Sunscreen cosmetics contain a relatively large amount of silicone oil so as to increase the feeling of use by suppressing stickiness and the like, and so as not to be easily removed from the skin by sweat or water. It is known that the ability of an ester oil to dissolve a silicone poorly soluble ultraviolet absorber is lowered in the presence of silicone oil because silicone oil and a silicone hardly soluble ultraviolet absorber have low compatibility.

  Therefore, in order to stably dissolve the silicone poorly soluble ultraviolet absorber in sunscreen cosmetics, there are restrictions on the type of absorbent and the silicone oil in the cosmetic, the blending ratio, etc. It was necessary to blend in.

  Incidentally, in Examples of Patent Documents 1 and 2, 1,3,5-triazine derivatives (2,4-bis-{[4-2 (ethylhexyloxy) -2-hydroxy] phenyl}) are used as hardly soluble ultraviolet absorbers. 6- (4-methoxyphenyl) -1,3,5-triazine) (Patent Document 1) or benzotriazole silicone (Patent Document 2: Compound (a)), and as ester oil, trimellitic acid ester (In the Example of patent document 1, the further small amount of silicone oil is mix | blended) is described.

  The skin composition contains an amount of the ester oil sufficient to dissolve the sparingly soluble ultraviolet absorber only with the ester oil (for example, 20 wt.% In Example 2 of Patent Document 1). %, 85% by weight in Examples 7 to 10 of Patent Document 2), the feeling of use of the composition is impaired by stickiness, shine and the like.

  In addition, Patent Documents 1 and 2 refer to non-polar oils and silicone oils as general descriptions for the components contained in the skin composition, but these are actually used as silicone poorly soluble ultraviolet absorbers and trimellitic acid. There is no disclosure of the effects used with esters.

  Patent Document 3 discloses in Example 11 as a lip cosmetic that maintains a cosmetic effect without feeling oily or sticky, has a high gloss feeling, and is excellent in stability over time at high temperatures. Lipstick containing 7% polyisobutene, 5% tridecyl trimellitic acid, 15% trimethylpentaphenyltrisiloxane and 1% p-methoxycinnamic acid-octyl is described.

JP-T-2004-520356 JP 2000-136110 A JP 2007-238578 A

New Cosmetic Handbook (Shigeru Sekine, published October 30, 2006, pages 446-454)

  In view of the above prior art, the present invention is a composition for external use containing a silicone hardly soluble UV absorber and a silicone oil, dissolves the silicone hardly soluble UV absorber without precipitating, and can be stably stored for a long period of time. Furthermore, it is intended to suppress stickiness and shine and achieve an excellent feeling of use.

  As a result of intensive studies to solve the above problems, the inventors of the present invention have (A) a silicone poorly soluble ultraviolet absorber, (B) trimellitic acid ester, (C) a modified silicone and / or a cyclic silicone, (D) By using together with a nonpolar oil, while precipitating a silicone oil having low compatibility with a silicone poorly soluble UV absorber, the precipitation of the silicone hardly soluble UV absorber is suppressed and stored stably for a long period of time. It was found that a composition for external use on the skin that was possible and that was excellent in feeling of use and in which stickiness and shine were suppressed was obtained, and the present invention was completed.

That is, the gist of the present invention is as follows.
<1> A composition for external use on skin containing (A) a silicone-poorly soluble ultraviolet absorber, (B) trimellitic acid ester, (C) a modified silicone and / or a cyclic silicone, and (D) a nonpolar oil.

  <2> The external composition for skin according to <1>, wherein the trimellitic acid ester (B) is contained in an amount of 0.1 to 20% by weight in 100% by weight of the external composition for skin.

  <3> The external composition for skin according to <1> or <2>, wherein 0.1 to 20 wt% of the nonpolar oil (D) is contained in 100 wt% of the external composition for skin.

  <4> The nonpolar oil (D) is squalane, liquid isoparaffin, liquid paraffin, light isoparaffin, light liquid paraffin, light liquid isoparaffin, heavy liquid paraffin, heavy liquid isoparaffin, hydrogenated polyolefin, hydrogenated polyisobutene, and The external composition for skin according to any one of <1> to <3>, which is at least one selected from the group consisting of hydrogenated polydecenes.

  <5> The silicone poorly soluble ultraviolet absorber (A) is at least one selected from the group consisting of a triazine derivative, a benzoate derivative, a benzophenone derivative, and a dibenzoylmethane derivative, <1> to <4 > The external composition for skin according to any one of the above.

  <6> The triazine derivative is 2,4-bis-{[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5- At least one selected from the group consisting of triazine, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, and diethylhexylbutamide triazine, < 5> The external composition for skin according to 5>.

  <7> The skin external application according to any one of <1> to <6>, wherein the trimellitic acid ester (B) is at least one selected from the group consisting of trioctyl trimellitic acid and tridecyl trimellitic acid. Composition.

  According to the present invention, while blending a silicone oil having low compatibility with a silicone poorly soluble ultraviolet absorber, the silicone poorly soluble ultraviolet absorber dissolves without depositing, and can be stably stored for a long period of time. It is possible to provide a composition for external use on the skin, in which the feeling and shine are suppressed and the feeling of use is excellent.

Hereinafter, the present invention will be described in detail.
[Skin external composition]
The composition for external use of the skin of the present invention contains (A) a poorly soluble ultraviolet absorber, (B) trimellitic acid ester, (C) a modified silicone and / or a cyclic silicone, and (D) a nonpolar oil. By using these in combination, the precipitation of the poorly soluble silicone ultraviolet absorber (A) in the composition is suppressed and dissolved, and the stickiness and shine are further suppressed in the composition to achieve an excellent usability. is there. Hereinafter, (A) silicone poorly soluble ultraviolet absorber, (B) trimellitic acid ester, (C) modified silicone and / or cyclic silicone, and (D) nonpolar oil which are essential constituents of the composition for external use of the present invention The other components that are optional components will be described.

<(A) Silicone poorly soluble UV absorber>
In the present specification, the silicone hardly soluble ultraviolet absorber (A) refers to an ultraviolet absorber having a skin protecting action from ultraviolet rays and low solubility in silicone.

  Examples of the silicone poorly soluble ultraviolet absorber (A) used in the present invention include triazine derivatives, benzoic acid ester derivatives, benzophenone derivatives, and dibenzoylmethane derivatives. In the present invention, the silicone poorly soluble ultraviolet absorber (A) can be used alone or in combination of two or more.

  (A) As a silicone poorly soluble ultraviolet absorber, a triazine derivative, a benzoic acid ester derivative, and a benzophenone derivative are preferable, and a triazine derivative is particularly preferable from the viewpoint of an ultraviolet protective effect.

  Examples of triazine derivatives used in the present invention include 2,4-bis-{[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1 , 3,5-triazine (Tinosorb S: BASF), 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine (Ubinal T-150: BASF) Heliosun OTZ: O'Laughlin Industries) and diethylhexylbutamide triazine (Uvasorb HEB: 3V SIGMA).

  The triazine derivative used in the present invention includes 2,4-bis-{[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl from the viewpoint of UV protection effect or versatility as a raw material. } -6- (4-methoxyphenyl) -1,3,5-triazine and 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine are preferred.

  Next, as an example of the benzoic acid ester derivative used in the present invention, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester (Ubinal Plus granular, Ubinal PlusB: BASF) may be mentioned. .

  Examples of the benzophenone derivative used in the present invention include 2-hydroxy-4-methoxybenzophenone (Ubinal M40: BASF, Escalol 567: ISP), dihydroxydimethoxybenzophenone (SEESORB107: Cypro Kasei), dihydroxybenzophenone ( SEESORB100: Cypro Kasei Co., Ltd.) and tetrahydroxybenzophenone (SEESORB106: Sipro Kasei Co., Ltd.).

  Examples of the dibenzoylmethane derivative used in the present invention include 4-tert-butyl-4'-methoxy-dibenzoylmethane (Pulsol 1789: DSM Nutrition Japan).

  As the silicone poorly soluble ultraviolet absorber (A) used in the present invention, 2,4-bis-{[4- (2-ethyl-hexyloxy)] is used from the viewpoint of ultraviolet protection effect or versatility as a raw material. -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3 Preferred is at least one selected from the group consisting of 5-triazine, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, and 4-tert-butyl-4′-methoxy-dibenzoylmethane. .

  The silicone poorly soluble ultraviolet absorber (A) described above is commercially available or can be produced by a known method.

  The content of the silicone poorly soluble ultraviolet absorber (A) in the external composition for skin of the present invention is usually 0.1 to 25% by weight in 100% by weight of the external composition for skin from the viewpoint of its effect, preferably 0.5 to 15% by weight.

<(B) trimellitic acid ester>
Trimellitic acid ester (B) is a component used for dissolving a poorly silicone-soluble component in a composition for external use on the skin. In the present invention, it suppresses precipitation of a silicone-insoluble ultraviolet absorber (A). . Because of the low compatibility between silicone oil and poorly soluble UV absorber (A), when silicone oil is added to the composition for external use, it dissolves the poorly soluble UV absorber (A) of trimellitic acid ester (B). The ability to be reduced, and it is necessary to blend a large amount of trimellitic acid ester (B). However, trimellitic acid ester is very sticky and causes shininess on the skin when applied, so a large amount has a great effect on the feeling of use. In the present invention, even when the blending amount of trimellitic acid ester (B) is reduced by using in combination with modified silicone and / or cyclic silicone (C) and nonpolar oil (D), which will be described later, the silicone hardly soluble UV absorption Agent (A) can be dissolved.

  The trimellitic acid ester (B) used in the present invention is preferably a trimellitic acid triester from the viewpoint of the dissolving power and feeling of use of the hardly-soluble silicone ultraviolet absorber (A). In this invention, trimellitic acid ester (B) can be used 1 type or in combination of 2 or more types.

  As the trimellitic acid triester, trioctyl trimellitic acid (Crodamol TOTM, SR Kurodamol TOTM: Croda), or tridecyl trimellitic acid (Cromida) from the viewpoint of the dissolving power and usability of the silicone poorly soluble ultraviolet absorber (A) LIPONATE TDTM: LIPGATE) is preferred, and trioctyl trimellitic acid is particularly preferred.

  The trimellitic acid ester (B) described above is commercially available or can be produced by a known method.

  The content of trimellitic acid ester (B) in the composition for external skin of the present invention is usually 0.1 to 20% by weight, preferably 1 to 20% in 100% by weight of the composition for external skin, from the viewpoint of its effect. 15% by weight. The composition for external use of the skin of the present invention contains a modified silicone and / or a cyclic silicone (C) having a low compatibility with the silicone poorly soluble ultraviolet absorber (A) as described later. In order to dissolve, a large amount of trimellitic acid ester (B) is required, but by using nonpolar oil (D) together, the amount of trimellitic acid ester (B) used can be reduced as described above. . Thereby, the sticky feeling and shine caused by trimellitic acid ester (B) can be suppressed.

  From the same viewpoint, in the external composition for skin of the present invention, trimellitic acid ester (B) is usually 0.001 to 30 parts by weight with respect to 1 part by weight of silicone poorly soluble ultraviolet absorber (A), Preferably 0.01 to 10 parts by weight is blended.

<(C) Modified silicone and / or cyclic silicone>
Modified silicone and / or cyclic silicone (C) are components used to improve the feeling of use of the composition for external use of the skin of the present invention. You can also.

  In this specification, the modified silicone refers to one obtained by substituting the methyl group of dimethicone with a functional group other than the methyl group (including hydrogen).

  In this specification, the cyclic silicone refers to a silicone having a cyclic methylpolysiloxane structure (a structure in which a siloxane chain forms a ring).

  Examples of the modified silicone and / or cyclic silicone (C) used in the present invention include methylphenyl silicone, cyclopentasiloxane, methyl hydrogen silicone, amino modified silicone, alkyl modified silicone, alcohol modified silicone, and silicone surfactant. Agents. In the present invention, the modified silicone and / or the cyclic silicone (C) can be used alone or in combination of two or more.

  Examples of the modified silicone and / or cyclic silicone (C) include methylphenyl silicone (KF56, KF54: Shin-Etsu Chemical Co., Ltd., SH556: Toray) from the viewpoints of solubility and usability of the silicone-insoluble UV absorber (A). Dow Corning Co., Ltd.), cyclopentasiloxane (KF995: Shin-Etsu Chemical Co., Ltd., SH245: Toray Dow Corning Co., Ltd.), methyl hydrogen polysiloxane (KF99, KF9901: Shin-Etsu Chemical Co., Ltd.), dimethylbenzalmalonate ( Pulsol SLX: DMS Nutrition Japan) and lauryl PEG-9 polydimethylsiloxyethyl dimethicone (KF6038: Shin-Etsu Chemical Co., Ltd.) are preferred, methylphenyl silicone, cyclopentasiloxane and dimethylbenza Lumalonate is particularly preferred.

  The modified silicone and / or cyclic silicone (C) described above are commercially available or can be produced by a known method.

  The content of the modified silicone and / or cyclic silicone (C) in the external composition for skin of the present invention is usually from 0.1 to 60% by weight in 100% by weight of the external composition for skin from the viewpoint of its effect, preferably Is 1 to 40% by weight.

  From the same viewpoint, in the composition for external use of the skin of the present invention, the modified silicone and / or cyclic silicone (C) is usually 0.1 to 60 with respect to 1 part by weight of the silicone poorly soluble ultraviolet absorber (A). Part by weight, preferably 0.5 to 10 parts by weight is blended.

  In addition, from the viewpoint of suppressing stickiness and shine, the modified silicone and / or cyclic silicone (C) in the composition for external use of the present invention is usually at 0. 1 part by weight relative to 1 part by weight of trimellitic acid ester (B). 0001 to 60 parts by weight, preferably 0.001 to 10 parts by weight is blended.

<(D) Nonpolar oil>
A nonpolar oil (D) is a component used in order to improve the compatibility of a silicone hardly soluble ultraviolet absorber (A) and modified silicone and / or cyclic silicone (C). Thereby, in the presence of the modified silicone and / or the cyclic silicone (C), particularly in the state where the component (C) is present in a large amount, the silicone hardly soluble ultraviolet absorber (A) is a small amount of trimellitic acid ester (B). In the composition for external use of the skin of the present invention, precipitation of the component (A) is suppressed and stable storage is possible.

  Examples of the nonpolar oil (D) used in the present invention include squalane, liquid isoparaffin, liquid paraffin, light isoparaffin, light liquid paraffin, light liquid isoparaffin, heavy liquid paraffin, heavy liquid isoparaffin, hydrogenated polyolefin, Examples thereof include hydrogenated polyisobutene and hydrogenated polydecene. In this invention, a nonpolar oil (D) can be used 1 type or in combination of 2 or more types.

  Specific examples of these commercially available products include squalane (Squalane: Nikko Chemicals), light liquid paraffin (Molesco White P-70: Moresco), heavy liquid paraffin (Molesco White P-350: Moresco), Examples thereof include hydrogenated polyisobutene (Pearl Ream Series: Nikko), hydrogenated polyolefin (Synthelan 4SP: Nikko Chemicals), hydrogenated polydecene (Silkflo 364 NF, Silklo 366 NF: LIPO CHEMICAL).

  The nonpolar oil (D) includes light liquid paraffin, heavy liquid paraffin, water from the viewpoint of improving the compatibility between the hardly-soluble silicone ultraviolet absorber (A) and the modified silicone and / or cyclic silicone (C). Hydrogenated polyolefin and hydrogenated polyisobutene are preferred.

  The nonpolar oil (D) demonstrated above is marketed or can be manufactured by a well-known method.

  The content of the nonpolar oil (D) in the external composition for skin of the present invention is usually 0.1 to 20% by weight, preferably 0.5 to 100% by weight in 100% by weight of the external composition for skin from the viewpoint of its effect. 15% by weight, more preferably 0.5 to 10% by weight.

  From the same viewpoint, in the external composition for skin of the present invention, the nonpolar oil (D) is usually 0.01 to 10 parts by weight, preferably 1 part by weight of the silicone poorly soluble ultraviolet absorber (A). Is blended in an amount of 0.1 to 7.5 parts by weight, more preferably 0.3 to 5 parts by weight.

  Further, from the viewpoint of suppressing stickiness and precipitation of the silicone-insoluble UV absorber (A), in the composition for external use of the present invention, 1 part by weight of trimellitic acid ester (B) is nonpolar oil (D ) Is preferably 0.1 to 7.5 parts by weight, more preferably 0.2 to 5 parts by weight.

  The composition for external use of the skin of the present invention comprises (A) a silicone poorly soluble ultraviolet absorber, (B) trimellitic acid ester, (C) a modified silicone and / or a cyclic silicone, and (D) a nonpolar oil. Therefore, the precipitation of the hardly soluble silicone ultraviolet absorber (A) can be suppressed, and it can be stored stably for a long period of time. Further, stickiness and shine are suppressed, and the usability is excellent. In the composition for external use of the skin of the present invention, the compatibility between the component (A) and the component (C) is improved by using the component (D) even in the presence of a large amount of the component (C). The amount of the component (B) used for dissolving the component A) can be reduced, which contributes to stickiness and shine suppression.

  From the viewpoint of suppressing stickiness, shine and precipitation of the silicone poorly soluble ultraviolet absorber (A), the silicone hardly soluble ultraviolet absorber (A) is 0.1 to 25 in 100% by weight of the external composition for skin of the present invention. % By weight, 0.1 to 20% by weight of trimellitic acid ester (B), 0.1 to 60% by weight of modified silicone and / or cyclic silicone (C), and 0.1 to 0.1% of nonpolar oil (D) 20% by weight is preferably blended. In addition, the sum total of (A)-(D) component is 100 weight% or less.

  From the same viewpoint, in 100% by weight of the external composition for skin of the present invention, 0.5-15% by weight of the silicone poorly soluble ultraviolet absorber (A), 1-15% by weight of trimellitic acid ester (B), and modification It is particularly preferable that 1 to 40% by weight of silicone and / or cyclic silicone (C) and 0.5 to 10% by weight of nonpolar oil (D) are blended.

<Other ingredients>
The composition for external use of the skin of the present invention includes the above-described silicone poorly soluble ultraviolet absorber (A), trimellitic acid ester (B), modified silicone and / or cyclic silicone (C), and nonpolar oil (D). In addition, according to various purposes, moisturizing ingredients, polyhydric alcohols, UV scattering ingredients, anti-inflammatory agents, astringent ingredients, vitamins, peptides or derivatives thereof, amino acids or derivatives thereof, antibacterial ingredients, keratin softness Other components such as a component, a cell activation component, an anti-aging component, a blood circulation promoting component, a whitening component, and an ultraviolet absorbing component may be included within a range not impairing the effects of the present invention. In addition, these other components may be used individually by 1 type, or may be used in combination of 2 or more type.

  Examples of the moisturizing component include diglycerin trehalose; high molecular compounds such as sodium hyaluronate, heparin-like substance, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, chitosan; amino acids such as glycine, aspartic acid, arginine; Natural moisturizing factors such as sodium, urea and sodium pyrrolidone carboxylate; lipids such as ceramide, cholesterol and phospholipid; plant extract extracts such as chamomile extract, hamamelis extract, tea extract and perilla extract.

  The polyhydric alcohol is preferably one having 2 to 10 carbon atoms, such as glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, 1 , 3-butylene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol, decanediol, neopentyl glycol and the like.

  Among these, glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol Glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, and hexanediol are more preferable.

  Examples of the ultraviolet scattering component include zinc silicate, cerium silicate, titanium silicate, zinc oxide, zirconium oxide, cerium oxide, titanium oxide, iron oxide, and other inorganic compounds, hydrous silicic acid and anhydrous silicic acid. , Coated with inorganic powder such as aluminum hydroxide, mica and talc, compounded with resin powder such as polyamide, polyethylene, polyester, polystyrene, nylon, and further treated with silicone oil or fatty acid aluminum salt Etc.

  Examples of the anti-inflammatory agent include glycyrrhetinic acid, glycyrrhizic acid derivatives, azulene, components derived from plants (for example, Comfrey), zinc oxide, tocopherol acetate, allantoin, aminocaproic acid, and hydrocortisone.

  Examples of the astringent component include zinc oxide, zinc sulfate, aluminum chloride, zinc sulfocolate and tannic acid.

  Examples of the vitamins include vitamin E such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate; riboflavin, flavin mononucleotide, flavin adenine di Vitamin B2 such as nucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5′-phosphate sodium, riboflavin tetranicotinate; nicotinic acid, nicotinic acid dl-α-tocopherol, benzyl nicotinate, methyl nicotinate, Nicotinic acids such as β-butoxyethyl nicotinate, 1- (4-methylphenyl) ethyl nicotinate and nicotinamide; ascorbigen-A, ascorbic acid stearate, ascorbic acid Vitamin Cs such as mitinate and L-ascorbyl dipalmitate; Vitamin Ds such as methyl hesperidin, ergocalciferol and cholecalciferol; Vitamin Ks such as phylloquinone and farnoquinone; γ-oryzanol, dibenzoylthiamine, di Benzoylthiamine hydrochloride; thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate ester, thiamine Vitamin B1 such as monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate; pyridoxine hydrochloride, pyridoacetate Vitamin B6 such as xin, pyridoxal hydrochloride, 5'-pyridoxal phosphate, pyridoxamine hydrochloride; vitamin B12 such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin; folic acid such as folic acid, pteroylglutamic acid; pantothenic acid, pantothenic acid Pantothenic acids such as calcium, pantothenyl alcohol (panthenol), D-panthecin, D-panthetin, coenzyme A, pantothenyl ethyl ether; biotins such as biotin and biocytin; ascorbic acid, sodium ascorbate, dehydroascorbic acid Vitamin Cs which are ascorbic acid derivatives such as sodium ascorbate phosphate, magnesium ascorbate phosphate; carnitine, ferulic acid, α-lipoic acid, orotic acid, etc. Such as vitamin-like agents, and the like.

  Examples of the peptide or derivatives thereof include keratin-degrading peptide, hydrolyzed keratin, collagen, collagen derived from fish, atelocollagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, and elastin-degrading Peptide, Conchiolin Degrading Peptide, Hydrolyzed Conchiolin, Silk Proteolytic Peptide, Hydrolyzed Silk, Lauroyl Hydrolyzed Silk Sodium, Soy Proteolytic Peptide, Hydrolyzed Soy Protein, Wheat Protein, Wheat Proteolytic Peptide, Hydrolyzed Wheat Protein, Casein Degradation Peptides, acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.) and the like can be mentioned.

  Examples of the amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, Examples include methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine and the like.

  Examples of the antibacterial component include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and derivatives thereof, popidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101 No., Photosensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, pyroctoolamine, miconazole and the like.

  Examples of the keratin flexible component include lactic acid, salicylic acid, salicylic acid glycolic acid, gluconic acid, citric acid, malic acid, fruit acid, phytic acid, urea, sulfur and the like.

  Examples of the cell activation component include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride and pantothenic acids; α-hydroxy acids such as glycolic acid and lactic acid; tannins , Flavonoids, saponins, photosensitive element 301 and the like.

  Examples of the anti-aging component include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivative, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone.

  Examples of the blood circulation promoting component include plants (for example, ginseng, ashitaba, arnica, ginkgo, fennel, enmelio, dutch oak, chamomile, roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake, ginger, hawthorn, prunus , Cucumber, assembly, thyme, clove, chimpi, capsicum, touki, tonin, spruce, carrot, garlic, butcher bloom, grapes, buttons, maronier, melissa, yuzu, yakuinin, ryokucha, rosemary, rosehip, chimpi, touki, Spruce, peach, apricot, walnut, corn) derived components; acetylcholine, ictamol, cantalis tincture, gamma-oryzanol, cephalanthin, trazoline, nicotinic tocopher Lumpur, such as hesperidin and the like.

  Examples of the whitening component include arbutin, tranexamic acid, vitamin C, vitamin C derivatives, tocopherol and the like.

  Examples of the ultraviolet absorbing component include ethylhexyl paramethoxycinnamate, ethylene glycol salicylate, octyl salicylate, homomenthyl salicylate, and the like.

  Furthermore, since the composition for external use of the present invention is applied to the skin, the above ingredients are usually diluted by adding water, and usually 0.1 to 90% by weight in 100% by weight of the composition for external use of the skin, Preferably 5 to 70% by weight of water is blended.

<Method for producing external composition for skin>
The method for producing the composition for external use of the skin of the present invention is not particularly limited, and is an essential component of a hardly-soluble silicone ultraviolet absorber (A), trimellitic acid ester (B), modified silicone and / or cyclic silicone (C), and In addition to the non-polar oil (D), various components necessary for producing a normal skin external composition (the above-mentioned other components, water, etc.) can be appropriately selected and blended, and can be produced by conventional methods. .

[Sunscreen cosmetics]
As described above, the composition for external use of the skin of the present invention suppresses the precipitation of the poorly soluble silicone ultraviolet absorber (A) and is stably dissolved, can be stably stored for a long period of time, and further suppresses stickiness and shine. In addition, no white residue occurs and the feeling of use is excellent.

  Therefore, the external composition for skin of the present invention can be suitably used as a sunscreen cosmetic for protecting the skin from ultraviolet rays, preventing sunburn and the like. The application amount and usage of the sunscreen cosmetic of the present invention to the outer skin are not particularly limited, and it can be used by applying, for example, applying an appropriate amount to the outer skin such as skin several times a day.

<Formulation>
Examples of the preparation form of the sunscreen cosmetic of the present invention include pharmaceuticals, quasi-drugs and cosmetics. In this case, the essential components and the other components described above are used as pharmaceuticals, quasi-drugs or cosmetics. Can be made into a sunscreen cosmetic in the form of these preparations by mixing in accordance with a conventional method together with a base or carrier usually used for the above and additives as described later if necessary.

  The sunscreen cosmetic may be either an oil-in-water type or a water-in-oil type emulsion, and can be selected depending on the feeling of use and the performance to be imparted.

  The form of the sunscreen cosmetic for the quasi-drug or cosmetic preparation is not particularly limited. For example, basic makeup such as lotion, spray, milky lotion, cream, serum, pack, hand cream, body lotion, body cream. Examples include makeup, makeup base, lip balm, lipstick, make-up cosmetics such as teak color, etc., and these preparations can be produced according to conventional methods.

  Furthermore, as the base or carrier, oils and fats such as coconut oil, olive oil, rice bran oil and shea butter; waxes such as jojoba oil, miw wax, candelilla wax, lanolin; cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, Higher alcohols such as octyldodecanol, isostearyl alcohol, phytosterol, cholesterol; cellulose derivatives such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose; polyvinyl pyrrolidone; carrageenan; polyvinyl butyrate; polyethylene glycol; dioxane; butylene glycol adipic acid polyester; Diisopropyl adipate, isopropyl myristate, octyldodecyl myristate, palmitic acid Esters such as sopropyl, cetyl palmitate, isononyl isononanoate, and pentaerythritol tetra-2-ethylhexanoate; polysaccharides such as dextrin and maltodextrin; vinyl polymers such as carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer; ethanol And lower alcohols such as isopropanol; glycol ethers such as diethylene glycol monoethyl ether; water and the like. When the sunscreen cosmetic of the present invention contains a polyhydric alcohol, the polyhydric alcohol may also serve as a base or carrier.

  When the sunscreen cosmetic of the present invention contains a base or carrier other than water, examples of the base or carrier include higher alcohols, fats and oils, waxes, ester oils (excluding trimellitic acid ester (B)), ethers Oils are preferred, and ester oils (excluding trimellitic acid ester (B)) and higher alcohols are more preferred. Among these components, cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, glyceryl tri-2-ethylhexanoate, and isononyl isononanoate are more preferable.

  The bases or carriers described above can be used singly or in combination of two or more, and the amount used thereof is appropriately selected from a range known to those skilled in the art.

<Additives>
In the sunscreen cosmetics of the present invention, known additives that are added to pharmaceuticals, quasi drugs or cosmetics within a range not impairing the effects of the present invention, for example, surfactants, antioxidants, colorants, A pearl luster imparting agent, a dispersing agent, a chelating agent, a pH adjusting agent, a preservative, a thickener, an irritation reducing agent, and the like can be added. These additives can be used alone or in combination of two or more.

  Examples of the surfactant include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, penta-octyl diglycerol sorbitan, tetra-octyl diglycerol sorbitan Propylene glycol fatty acid esters such as propylene glycol monostearate; polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO) -60), hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 80; polyoxyethylene (20) sorbitan (polysorbate 20) monolaurate, polyoxyethylene monostearate Polyoxyethylene sorbitan fatty acid esters such as poly (20) sorbitan (polysorbate 60), polyoxyethylene monooleate (20) sorbitan (polysorbate 80), polyoxyethylene (20) sorbitan isostearate; polyoxyethylene monococonut oil Examples thereof include fatty acid glyceryl; glycerin alkyl ether; alkyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; amines such as stearylamine and oleylamine.

  Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride, and the like.

  Examples of the colorant include inorganic pigments and natural pigments.

  Examples of the pearl luster imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

  Examples of the dispersant include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinyl pyrrolidone, methyl vinyl ether / maleic anhydride crosslinked copolymer, and organic acid.

  Examples of the chelating agent include EDTA · disodium salt and EDTA · calcium disodium salt.

  Examples of the pH adjuster include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, water, etc.). Sodium oxide), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.).

  Examples of the preservative include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and paraoxybenzoic acid. Examples include benzyl, methyl paraoxybenzoate, and phenoxyethanol.

  Examples of the thickener include cellulose-based thickeners such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxyethylcellulose, guar gum, pectin, pullulan, gelatin, locust bean Gum, carrageenan, agar, xanthan gum, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, sodium chondroitin sulfate, hyaluronic acid, hyaluronic acid Sodium, (hydroxyethyl acrylate / Acryloyl dimethyl taurine Na) copolymer, and the like (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer.

  Examples of the irritation reducing agent include licorice extract, sodium alginate, gum arabic, polyvinyl pyrrolidone, licorice extract and the like.

  EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited at all by these. In the examples, comparative examples, and formulation examples shown below, the numerical units are all g (grams).

[Solubility test]
According to the weight ratio composition described in Table 1 below, each component was mixed in a 100 ml beaker and heated to 80 ° C. while stirring using a magnetic stirrer. Next, the mixture was cooled to room temperature while stirring using a magnetic stirrer, and the resulting mixture was dispensed into a 50 ml screw cap bottle in 40 ml portions. And it was left to stand at room temperature for 4 days, and the presence or absence of precipitation of a component was observed.

析出状態：
○：成分の析出が観察されなかった。 ×：成分の析出が観察された。
＊トリメリット酸トリオクチル：ＳＲ クロダモル ＴＯＴＭ（クローダ社）、以下同じ
＊２，４−ビス−｛[４−（２−エチル−ヘキシルオキシ）−２−ヒドロキシ]−フェニル｝−６−（４−メトキシフェニル）−１，３，５−トリアジン：チノソーブＳ（ＢＡＳＦ社）、以下同じ
＊シクロペンタシロキサン：ＫＦ９９５（信越化学工業社）、以下同じ
＊水添ポリオレフィン：シンセラン４ＳＰ（日光ケミカルズ社）、以下同じ

Precipitation state:
○: No component precipitation was observed. X: Precipitation of components was observed.
* Trioctyl trimellitic acid: SR Crodamole TOTM (Cloda), the same * 2,4-bis-{[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxy Phenyl) -1,3,5-triazine: Tinosorb S (BASF), the same * cyclopentasiloxane: KF995 (Shin-Etsu Chemical Co., Ltd.), and so on * Hydrogenated polyolefin: Synthelan 4SP (Nikko Chemicals), and so on

  The external composition for skin of the present invention is usually obtained by adding and mixing other components such as water to the compositions shown in Table 1. In that case, it is diluted about 0.5 to 20 times. The same applies to the compositions not containing water in the following table.

  From this result, even when silicone oil is used, the use of trimellitic acid ester and nonpolar oil prevents precipitation of the silicone poorly soluble ultraviolet absorber, and the ultraviolet absorber can be dissolved stably. confirmed. In addition, the amount of trimellitic acid ester used to dissolve the silicone poorly soluble ultraviolet absorber could be reduced.

[Study of poorly soluble UV absorbers]
As in the case of [Solubility test], compositions were prepared according to the weight ratio compositions described in Tables 2-1 to 2-3 below, and they were allowed to stand at room temperature for 4 days. The presence or absence was observed. The results are shown in Tables 2-1 to 2-3 below.

析出状態：
○：成分の析出が観察されなかった。 ×：成分の析出が観察された。
＊２，４，６−トリス[４−（２−エチルヘキシルオキシカルボニル）アニリノ]−１，３，５−トリアジン：ユビナールＴ−１５０（ＢＡＳＦ社）、以下同じ
＊水添ポリイソブテン：パールリーム３（日油社）、以下同じ
＊重質流動パラフィン：モレスコホワイト Ｐ−３５０（モレスコ社）、以下同じ
＊軽質流動パラフィン：モレスコホワイト Ｐ−７０（モレスコ社）、以下同じ

Precipitation state:
○: No component precipitation was observed. X: Precipitation of components was observed.
* 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine: Ubinal T-150 (BASF), the same below * Hydrogenated polyisobutene: Pearl Ream 3 (day Oil Co., Ltd.), the same * Heavy liquid paraffin: Moresco White P-350 (Moresco), the same * Light liquid paraffin: Moresco White P-70 (Moresco), the same

析出状態：
○：成分の析出が観察されなかった。 ×：成分の析出が観察された。
＊２−[４−（ジエチルアミノ）−２−ヒドロキシベンゾイル]安息香酸ヘキシルエステル：ユビナールＡｐｌｕｓグラニュラー（ＢＡＳＦ社）、以下同じ

Precipitation state:
○: No component precipitation was observed. X: Precipitation of components was observed.
* 2- [4- (Diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester: Ubinal Plus granular (BASF), the same applies hereinafter

析出状態：
○：成分の析出が観察されなかった。 ×：成分の析出が観察された。
＊４−ｔｅｒｔ−ブチル−４’−メトキシ−ジベンゾイルメタン：パルソール１７８９（ＤＳＭニュートリションジャパン社）、以下同じ

Precipitation state:
○: No component precipitation was observed. X: Precipitation of components was observed.
* 4-tert-Butyl-4'-methoxy-dibenzoylmethane: Pulsol 1789 (DSM Nutrition Japan), the same applies hereinafter

  As shown in Table 2-1 to Table 2-3, as a result of the same test with various silicone poorly soluble ultraviolet absorbers, by using trimellitic acid ester and nonpolar oil in the presence of specific silicone oil, Precipitation of any of the silicone hardly soluble UV absorbers was suppressed, and the silicone hardly soluble UV absorber could be stably dissolved.

[Examination of ester oil]
As in the case of [Solubility Test], compositions were prepared according to the weight ratio composition described in Table 3 below, and they were allowed to stand at room temperature for 4 days, and the presence or absence of component precipitation was observed. The results are shown in Table 3 below.

析出状態：
○：成分の析出が観察されなかった。
×：成分の析出が観察された（×の個数が多いほど、析出が多いことを示す）。

Precipitation state:
○: No component precipitation was observed.
X: Precipitation of the component was observed (the more the number of x, the greater the precipitation).

  When trimellitic acid triester was changed to another ester oil, a silicone poorly soluble ultraviolet absorber was deposited.

[Examination of trimellitic acid ester]
As in the case of [Solubility test], compositions were prepared according to the weight ratio compositions described in Table 4 below, and they were allowed to stand at room temperature for 4 days, and the presence or absence of component precipitation was observed. The results are shown in Table 4 below.

析出状態：
○：成分の析出が観察されなかった。

Precipitation state:
○: No component precipitation was observed.

[Examination of silicone oil]
As in the case of [Solubility test], compositions were prepared according to the weight ratio compositions described in Table 5 below, and they were left at room temperature for 10 days to observe the presence or absence of component precipitation. The results are shown in Table 5 below.

析出状態：
○：成分の析出が観察されなかった。
溶解せず：各成分を混合し、８０℃まで加熱しても、各成分が溶解しなかったことを示す。

Precipitation state:
○: No component precipitation was observed.
Not dissolved: Each component was mixed and heated to 80 ° C., indicating that each component did not dissolve.

  As shown in Table 5, when the modified silicone and cyclic silicone were changed to dimethicone, each component did not dissolve during preparation.

[Examination of oil components]
As in the case of [Solubility Test], compositions were prepared according to the weight ratio composition described in Table 6 below, and they were allowed to stand at room temperature for 4 days, and the presence or absence of component precipitation was observed. The results are shown in Table 6 below.

析出状態：
○：成分の析出が観察されなかった。
×：成分の析出が観察された（×の個数が多いほど、析出が多いことを示す）。

Precipitation state:
○: No component precipitation was observed.
X: Precipitation of the component was observed (the more the number of x, the greater the precipitation).

  When the nonpolar oil was changed to hexyl decanol, isostearyl alcohol, which is a higher alcohol, or isostearic acid, which is a fatty acid, a poorly silicone-soluble UV absorber was deposited.

[Examination of nonpolar oil]
As in the case of [Solubility test], compositions were prepared according to the weight ratio compositions described in the following Tables 7-1 to 7-2 and left at room temperature for 4 days to check whether or not the components were precipitated. Was observed. The results are shown in Tables 7-1 to 7-2 below.

析出状態：
○：成分の析出が観察されなかった。
溶解せず：各成分を混合し、８０℃まで加熱しても、各成分が溶解しなかったことを示す。
＊軽質流動イソパラフィン：パールリーム４（日油社）、以下同じ
＊重質流動イソパラフィン：パールリーム６（日油社）、以下同じ

Precipitation state:
○: No component precipitation was observed.
Not dissolved: Each component was mixed and heated to 80 ° C., indicating that each component did not dissolve.
* Light liquid isoparaffin: Pearl Ream 4 (Nippon Oil Co., Ltd.), and so on. * Heavy liquid isoparaffin: Pearl Ream 6 (Nippon Oil Co., Ltd.), and so on.

析出状態：
○：成分の析出が観察されなかった。 ×：成分の析出が観察された。

Precipitation state:
○: No component precipitation was observed. X: Precipitation of components was observed.

  As shown in Table 7-1, the silicone poorly soluble ultraviolet absorber did not precipitate in various nonpolar oils. Moreover, as shown in Table 7-2, even when cyclopentasiloxane was blended at a high concentration, the hardly-soluble silicone ultraviolet absorber did not precipitate.

[Formulation study 1]
In accordance with the weight ratio composition shown in Table 8 below, each oil-soluble component is mixed to form an oil phase and each water-soluble component is mixed to form an aqueous phase, and each phase is mixed and dissolved at 70 to 80 ° C. While stirring with a mixer, the aqueous phase was added to the oil phase and sufficiently emulsified. Thereafter, the mixture was cooled to room temperature with stirring to obtain a water-in-oil preparation. Each formulation was filled into a glass screw cap bottle (30 mL) so that the voids in the bottle were uniform, and allowed to stand at room temperature for 4 days, and the presence or absence of precipitation of components was observed. The results are shown in Table 8 below.

析出状態：
○：成分の析出が観察されなかった。 ×：成分の析出が観察された。

Precipitation state:
○: No component precipitation was observed. X: Precipitation of components was observed.

  Moreover, about the solubility of the composition which consists only of an essential component of the external composition for skin of this invention among the structural components of each formulation shown in Table 8, it carried out similarly to said [Solubility test], and said composition. The mixture was allowed to stand at room temperature for 4 days, and the presence or absence of component precipitation was observed. The results are shown in Table 9 below.

析出状態：
○：成分の析出が観察されなかった。 ×：成分の析出が観察された。

Precipitation state:
○: No component precipitation was observed. X: Precipitation of components was observed.

[Formulation study 2]
According to the weight ratio composition shown in Table 10 below, each oil-soluble component is mixed to form an oil phase and each water-soluble component is mixed to form an aqueous phase, and each phase is mixed and dissolved at 70 to 80 ° C. While stirring with a mixer, the oil phase was added to the aqueous phase and sufficiently emulsified. Thereafter, the mixture was cooled to room temperature with stirring to obtain an oil-in-water preparation.

  Each formulation was filled into a glass screw cap bottle (30 mL) so that the gaps in the bottle were uniform, left standing in a constant temperature bath at 4 ° C. for 1 month, and then observed for the presence or absence of component precipitation. The results are shown in Table 10 below.

析出状態：
○：成分の析出が観察されなかった。 ×：成分の析出が観察された。

Precipitation state:
○: No component precipitation was observed. X: Precipitation of components was observed.

  Further, among the constituent components of each preparation shown in Table 10, the solubility of the composition consisting only of the essential components of the external composition for skin of the present invention is 4 days at room temperature in the same manner as in the above [Solubility test]. It was allowed to stand and the presence or absence of component precipitation was observed. The results are shown in Table 11 below.

析出状態：
○：成分の析出が観察されなかった。 ×：成分の析出が観察された。

Precipitation state:
○: No component precipitation was observed. X: Precipitation of components was observed.

[Usability test and observation with a microscope]
Each of the preparations having the composition described in Table 12 below was used by 6 panelists, and the evaluation score was assigned as follows for each item of use feeling.

  For the evaluation item “skin familiarity / moist feeling / smooth feeling”, the evaluation score is “good: 2 points, slightly good: 1 point, neither can be said: 0 points, not so good: −1 points, bad: −2 Point.

  For the evaluation item “squeak”, the evaluation score was “No: 2 points, not so much: 1 point, neither can be said: 0 points, a little: −1 point, some: −2 points”

  For each evaluation item, the total score of the six evaluation points is shown in Table 12 below as ◎: 8 points or more, ◯: 1 to 7 points, and X: 0 points or less.

  Furthermore, Table 12 shows the results of observing the presence or absence of component precipitation of each preparation left in a 4 ° C. constant temperature bath for 1 month with a microscope (VHX-1000: Keyence Corporation).

析出状態：
○：成分の析出が観察されなかった。 ×：成分の析出が観察された。

Precipitation state:
○: No component precipitation was observed. X: Precipitation of components was observed.

  As a result, a combination of trimellitic acid ester, a silicone poorly soluble UV absorber, a cyclic silicone, and a nonpolar oil can be used to stably add a poorly soluble component without precipitation, and a good usability of the preparation can be obtained. I understood.

[Prescription example]
Hereinafter, formulation examples of the external composition for skin of the present invention will be shown. In the following, all the numerical units are (g).

Formulation Example 1 Sunscreen Cosmetics Each component shown in Table 13 below was mixed to prepare a sunscreen cosmetic.

Formulation Example 2 Sunscreen Cosmetics Each component described in Table 14 below was mixed to prepare a sunscreen cosmetic.

Formulation Example 3 Sunscreen Spray Each component described in Table 15 below was mixed and filled in a spray can so that the chemical solution: LPG = 30: 70, and a sunscreen spray was prepared.

  Moreover, it was confirmed by this inventor that the (B) component of this invention also shows a whitening effect. It can be expected that this effect will be enhanced by blending it into sunscreen cosmetics and whitening cosmetics.

[Melanin production inhibition test]
Mouse-derived melanoma cells were seeded on a 6-well plate at a density of 1.0 × 10 ⁴ cells / mL using a DMEM medium containing 10% FBS, and in an environment of 37 ° C., 5% carbon dioxide and 95% air. After culturing for 4 hours, the medium was changed and the test drugs shown in Table 16 below were added at various concentrations, followed by further culturing for 3 days. After incubation, remove the supernatant, wash once with PBS (−), add 600 μL of 1N NaOH, let stand at room temperature for 24 hours to lyse the cells, and measure the absorbance of light at a wavelength of 475 nm. Thus, the amount of melanin produced was determined, and the relative amount (melanin production rate per amount of protein compared to control) compared to the case where the test drug was not added (control) was determined. The amount of protein was quantified using a BCA protein quantification kit, and the cell viability was calculated.

  The whitening effect of trioctyl trimellitic acid was similar to that of ascorbic acid glucoside and arbutin known as whitening agents. From this fact, when trimellitic acid ester is blended in sunscreen cosmetics and whitening cosmetics, it is possible to improve skin spots and darkening.

Claims (5)

(A) a silicone poorly soluble ultraviolet absorber;
(B) trimellitic acid ester;
(C) modified silicone and / or cyclic silicone;
(D) a nonpolar oil and a silicone poorly soluble ultraviolet absorber (A) is 2,4-bis-{[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6 -(4-methoxyphenyl) -1,3,5-triazine, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, 2- [4- ( Diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, and 4-tert-butyl-4′-methoxy-dibenzoylmethane, which is at least one selected from the group consisting of 100% by weight of an external composition for skin. A composition for external use on skin having a trimellitic acid ester (B) content of 1 wt% to 15 wt% and a nonpolar oil (D) content of 0.5 wt% to 15 wt%. During pre-Symbol skin external composition, the silicone flame-soluble ultraviolet absorber (A) with respect to 1 part by weight, trimellitic acid ester (B) is contained in an amount of 0.01 to 10 parts by weight, according to claim 1 Skin external composition. During pre-Symbol skin external composition, the silicone flame-soluble ultraviolet absorber (A) with respect to 1 part by weight, the non-polar oil (D) is contained in an amount of 0.1 to 7.5 parts by weight, according to claim 1 or 2. An external composition for skin according to 2. During pre-Symbol skin external composition, the silicone flame-soluble ultraviolet absorber (A) with respect to 1 part by weight, modified silicone and / or cyclic silicone (C) is contained in a proportion of 0.1 to 60 parts by weight, claim The external composition for skin according to any one of 1 to 3.   The non-polar oil (D) is squalane, liquid isoparaffin, liquid paraffin, light isoparaffin, light liquid paraffin, light liquid isoparaffin, heavy liquid paraffin, heavy liquid isoparaffin, hydrogenated polyolefin, hydrogenated polyisobutene, and hydrogenated polydecene. The external composition for skin according to any one of claims 1 to 4, which is at least one selected from the group consisting of: