JP7488667B2 - Mask preparation - Google Patents

Description

Application of Article 30, Paragraph 2 of the Patent Act Distributed in electronic form at Rohto Pharmaceutical Co., Ltd. on November 14, 2018 as a document that can be presented to sales agents, retailers, and other parties who are not bound by confidentiality obligations Distributed at Spiral Hall on November 22, 2018 to magazine editors, writers, and other parties who are not bound by confidentiality obligations

The present invention relates to a mask formulation.

In recent years, mask preparations have been sold in the cosmetics market, primarily for beauty purposes, and contain hyaluronic acid, ceramide, collagen, and other ingredients that have moisturizing properties. In order to meet the various needs of consumers, companies have been working tirelessly to research the feel of masks when used, as disclosed in, for example, Patent Document 1 (JP Patent Publication No. 2008-50305) and Patent Document 2 (JP Patent Publication No. 2011-84539).

On the other hand, tranexamic acid, nicotinamide, ascorbic acid glucoside, 3-O-ethyl ascorbic acid, etc. are known to have whitening effects.

JP 2008-50305 A JP 2011-84539 A

The objective of the present invention is to provide a mask formulation that provides a refreshing feel when used and has excellent adhesion to the skin.

[1] A nonwoven fabric having a basis weight of 40 g/m ² to 80 g/m ² ;
A mask composition impregnated into the nonwoven fabric,
The mask composition comprises:
(A) 0.5% by mass or more of a water-soluble active ingredient having a log P value of 0 or less and a molecular weight of 1,000 or less;
(B) 60% by mass or more of at least one of water and a lower alcohol,
(C) 1% by mass or more and less than 30% by mass of a polyol;
(D) at least one polymer compound,
A mask formulation, wherein the viscosity of the mask composition is 3000 mPa·s or more.

[2] The mask formulation according to [1], wherein the active ingredient is at least one ingredient selected from the group consisting of tranexamic acid and its salts, ascorbic acid glucoside, 3-O-ethyl ascorbic acid, and nicotinamide.

[3] The mask formulation according to [1] or [2], wherein the content of tranexamic acid in the mask composition is 0.5 to 10% by mass.

[4] The mask formulation according to any one of [1] to [3], wherein the nicotinamide content in the mask composition is 0.5 to 10% by mass.

[5] The mask formulation according to any one of [1] to [4], wherein the viscosity of the mask composition is 3,000 to 30,000 mPa·s.

[6] The mask formulation according to any one of [1] to [5], wherein the L value of the cosmetic of the mask composition in the Lab color system is 50 to 100.

[7] A nonwoven fabric having a basis weight of 40 g/m ² to 80 g/m ² ;
A mask formulation kit comprising:
The mask composition comprises:
(A) 0.5% by mass or more of a water-soluble active ingredient having a log P value of 0 or less and a molecular weight of 1,000 or less;
(B) 60% by mass or more of at least one of water and a lower alcohol,
(C) 1% by mass or more and less than 30% by mass of a polyol;
(D) at least one polymer compound,
The mask formulation kit, wherein the viscosity of the mask composition is 3000 mPa·s or more.

The present invention provides a mask formulation that provides a refreshing feel when used and has excellent adhesion to the skin.

<Mask preparation>
The mask formulation of the present invention comprises a nonwoven fabric and a mask composition containing tranexamic acid impregnated into the nonwoven fabric.

[Nonwoven fabric]
The nonwoven fabric used in the mask preparation of this embodiment has a basis weight of 40 g/m ² to 80 g/m ^2. In this case, the nonwoven fabric has good impregnation and is less prone to twisting.

The material of the fibers constituting the nonwoven fabric preferably includes at least one of rayon, cotton linters, and cotton. The nonwoven fabric may also include polyethylene terephthalate (PET), polypropylene (PP), pulp, hemp, acrylic, nylon, silk, polyamide, polyurethane, etc.

When the nonwoven fabric contains PET, the PET content in the nonwoven fabric is preferably less than 60% by mass, and more preferably 50% by mass or less, although this is not particularly limited. When the nonwoven fabric contains cotton or cotton linters, the total content of cotton or cotton linters in the nonwoven fabric is preferably 40% by mass or more, and more preferably 50% by mass or more.

[Mask Composition]
The mask composition used in the mask formulation of this embodiment (impregnated into the nonwoven fabric) contains at least the following components (A) to (D).

(A) Active Ingredient The log P value of the active ingredient is 0 or less, and the molecular weight is 1000 or less. The log P value is an index representing the hydrophilicity or hydrophobicity of a substance, and is the common logarithm of the partition coefficient of a substance (biologically active ingredient) between an octanol phase and an aqueous phase, as defined in Chemical Review vol71(6), 525(1971), etc. The log P value can be calculated using calculation software (for example, "CS Chem3D ver.9.0" (trade name) manufactured by Cambridgesoft).

The active ingredient is preferably at least one ingredient selected from the group consisting of tranexamic acid and its salts, ascorbic acid glucoside, 3-O-ethyl ascorbic acid, and nicotinamide. These ingredients are also known as skin-whitening ingredients. Examples of salts of tranexamic acid include alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt and magnesium salt; zinc salt; iron salt; ammonium salt; salts with basic amino acids such as arginine, lysine, histidine, and ornithine; and salts with amines such as monoethanolamine, diethanolamine, and triethanolamine. Among these, the sodium salt, potassium salt, triethanolamine salt, and arginine salt are preferred, and the sodium salt is more preferred.

The active ingredients in the mask composition may be used alone or in combination of two or more kinds. The content of component (A) in the composition can be selected depending on the application of the composition and the function of the water-soluble component (A), and the content is, for example, 0.5% to 10.0% by mass, preferably 1.0% to 9.0% by mass, and more preferably 2.0% to 7.0% by mass, based on the total amount of the composition.

The proportion of component (A) may be, for example, about 0.005 to 0.2 parts by mass, preferably about 0.008 to 0.15 parts by mass, and more preferably about 0.01 to 0.14 parts by mass, per part by mass of component (B).

The proportion of component (A) may be, for example, about 0.01 to 10 parts by mass, preferably about 0.03 to 5 parts by mass, and more preferably about 0.04 to 2.0 parts by mass, per part by mass of component (C).

When the composition contains components (B) and (C), the proportion of component (A) may be, for example, about 0.001 to 0.20 parts by mass, preferably about 0.005 to 0.15 parts by mass, and more preferably about 0.01 to 0.12 parts by mass, per part by mass of the total amount of components (B) and (C).

When using a water-soluble active ingredient with a log P value of 0 or less and a molecular weight of 1000 or less, adding a certain level of viscosity to the mask will suppress the skin from feeling rough after use. In addition, adding a water-soluble active ingredient with a log P value of 0 or less and a molecular weight of 1000 or less to a mask with a certain level of viscosity will improve the adhesion and penetration of the mask formulation. It will also improve the liquid retention and preservative power.

In addition, it has been newly discovered that depending on the beauty ingredients and the amounts of ingredients contained in the mask formulation, it can cause the skin to feel rough, and that poor adhesion of the mask, dryness during use, and poor absorption can lead to the feeling of roughness.

According to research by the present inventors, it has been found that a jelly-like composition containing at least 60% by mass of water and/or a lower alcohol, at least 1% by mass and less than 30% by mass of a polyol, and at least one type of polymer compound, and having a viscosity of 3000 mPa·s or more, when impregnated into a nonwoven fabric having a basis weight of 40 g/m ² to 80 g/m ² , provides a mask formulation that provides an unprecedentedly fresh feel when used and has excellent adhesion to the skin.

Even more surprisingly, it was found that when the above composition was combined with a water-soluble active ingredient with a log P value of 0 or less and a molecular weight of 1000 or less, the mask showed improved liquid retention and preservative properties compared to conventional masks.

When the active ingredient is tranexamic acid, the content of tranexamic acid in the mask composition is preferably 0.5% by mass or more and 10% by mass or less, more preferably 1.0% by mass or more and 5% by mass or less, and even more preferably 1.5% by mass or more and 3% by mass or less. Most preferably, it is 2% by mass or more and 2.5% by mass or less. Within this range, the above effects are more reliably exhibited, and the whitening effect is also fully exhibited.

When the active ingredient is nicotinamide, the content of nicotinamide in the mask composition is preferably 0.5% by mass or more and 10% by mass or less, more preferably 1% by mass or more and 8% by mass or less, and even more preferably 3% by mass or more and 7% by mass or less. Most preferably, it is 5% by mass or more and 5.5% by mass or less. Within this range, the above effects are more reliably exhibited, and the whitening effect is also fully exhibited. Furthermore, in addition to the whitening use, an anti-wrinkle effect can be expected, and the anti-aging care effect can also be fully exhibited.

(B) Water, lower alcohol The mask composition contains at least one of water and a lower alcohol. The mask composition preferably contains at least 50% by mass of water. The total content of water and lower alcohol in the mask composition is 60% by mass or more. The upper limit of the total content of water and lower alcohol in the mask composition is not limited, but may be 98% by mass or less, 95% by mass or less, 93% by mass or less, or 90% by mass or less. The proportion of the (B) component may be, for example, 1 to 100 parts by mass, preferably 5 to 80 parts by mass, and more preferably about 8 to 50 parts by mass, relative to 1 part by mass of the (A) component.

Examples of lower alcohols include ethanol and isopropanol.

(C) Polyol (polyhydric alcohol)
The mask composition used in the present embodiment contains a polyol, which is preferably at least one polyol selected from the group consisting of butylene glycol, propylene glycol, 1,3 propanediol, dipropylene glycol, glycerin, sorbitol, and diglycerin.
The total content of polyols in the mask composition is 1% by mass or more and less than 30% by mass, preferably 2% by mass or more and less than 28% by mass, and more preferably 5% by mass or more and less than 25% by mass. The proportion of component (C) may be, for example, about 0.1 to 15 parts by mass, preferably 0.2 to 14 parts by mass, and more preferably about 0.5 to 13 parts by mass, per part by mass of component (A).

(D) Polymer Compound The mask composition further includes at least one polymer compound.
Examples of the polymer compound include carboxyvinyl polymer, acrylic acid/alkyl methacrylate copolymer, (ammonium acryloyldimethyltaurate/vinylpyrrolidone) copolymer, (ammonium acryloyldimethyltaurate/methacrylic acid/ammonium methacrylate/dimethylacrylamide) copolymer, (ammonium acryloyldimethyltaurate/beheneth-25 methacrylate) crosspolymer, polyacrylic acid and its salts, polyacrylamide, (hydroxyethyl acrylate/Na acryloyldimethyltaurate) copolymer, (acrylic acid/Na methacrylate/dimethylacrylamide) crosspolymer ... Hydroxyethyl acrylate/Sodium acryloyldimethyltaurate copolymer, polyacrylate crosspolymer-6, Sodium acrylate/Sodium acryloyldimethyltaurate copolymer, Acrylamide/Ammonium acrylate copolymer, Acrylates crosspolymer, Acrylates copolymer, PEG-240/HDI copolymer bisdecyltetradeceth-20 ether, Steareth-100/PEG-136/HDI copolymer, Hyaluronic acid and its salts, Gellan gum, Xanthan gum, Polyvinyl alcohol, Polyvinylpyrrolidone, Guar gum , hydroxypropyl guar gum, cellulose-based polymer compounds (e.g., methylcellulose, ethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, etc.), starch-based polymers (e.g., carboxymethylstarch, methylhydroxypropylstarch, etc.), gum arabic, karaya gum, tragacanth gum, galactan, carob gum, quince seed, algae colloid (cassou extract), alginic acid-based polymers (e.g., sodium alginate, propylene glycol alginate, etc.), esters, etc.), xanthan gum, agar, alginic acid, mucopolysaccharides (for example, heparinoids, heparin, heparin sulfate, heparan sulfate, heparinoids, hyaluronic acid, hyaluronates (sodium salts, etc.), starch, dextran, succinoglucan, gelatin, casein, albumin, chitin and derivatives thereof, chitosan and derivatives thereof, carrageenan, Tremella fuciformis polysaccharides, etc., preferably carboxyvinyl polymers, acrylic acid/alkyl methacrylate copolymers, hyaluronic acid and salts thereof, gellan gum, and Tremella fuciformis polysaccharides.

(viscosity)
The viscosity of the mask composition is 3000 mPa·s or more, preferably 3000 to 50000 mPa·s, more preferably 3300 to 40000 mPa·s, and even more preferably 3500 to 30000 mPa·s. The viscosity of the mask composition is a value measured using a VISCOMETER TV-10 (manufactured by Toki Sangyo Co., Ltd.) under the following measurement conditions: rotor M4, rotation speed 12 rpm, and rotation time 60 seconds.

The mask composition of this embodiment satisfies the above requirements (B) to (D) and viscosity, and thus provides a fresh, jelly-like feel when used, and can provide a mask formulation (jelly mask) (see, for example, Patent Documents 1 to 3).

(L value)
The L value of the mask composition in the Lab color system (Hunter Lab system) of cosmetics is preferably 50 to 100, more preferably 60 to 100, even more preferably 70 to 100, still more preferably 80 to 100, and most preferably 90 to 100.

The L value in the Lab color system for cosmetics is a value that represents the transparency when the transparency of purified water is set to 100 and no light transmission is set to 0. In other words, the closer the L value is to 100, the higher the transparency. The L value can be measured, for example, by placing the test liquid in a glass cell (CM-A99, thickness 20 mm) and using a spectrophotometer CM-5 (manufactured by Konica Minolta, Inc.). The mask composition of this embodiment is a transparent or translucent composition with an L value of 50 or more. This has the advantage of giving a fresh impression to the eye and appealing to the psychology of the user.

(pH)
The pH of the mask composition is preferably 3.0 to 9.0, more preferably 3.5 to 8.0, and even more preferably 4.0 to 7.5. Within the above range, active ingredients (e.g., tranexamic acid, nicotinamide) and the like tend to be stable in the formulation, and irritation to the skin can be avoided.

(Other ingredients)
The mask composition may contain an acid or a salt thereof in addition to the above components. Examples of the acid or a salt thereof include organic acids such as lactic acid, sodium lactate, citric acid, sodium citrate, malic acid, sodium malate, succinic acid, sodium succinate, tartaric acid, sodium tartrate, gluconic acid, and sodium gluconate, and inorganic acids such as phosphoric acid, hydrochloric acid, and sulfuric acid. These acids may be used as pH adjusters. Organic bases such as triethanolamine, diisopropanolamine, triisopropanolamine, and arginine, and inorganic bases such as potassium hydroxide and sodium hydroxide may also be used as pH adjusters.

The mask composition may further contain pharma- ceutical or physiologically acceptable active ingredients used in topical drugs, quasi-drugs, cosmetics, etc. Examples of such active ingredients include moisturizing ingredients, anti-inflammatory ingredients, antibacterial ingredients, vitamins, peptides or derivatives thereof, amino acids or derivatives thereof, cell activating ingredients, anti-aging ingredients, blood circulation promoting ingredients, keratin softening ingredients, whitening ingredients, astringent ingredients, etc.
In the present invention, even if such active ingredients are contained, the functions of the above-mentioned components (A) to (D) can be effectively exhibited.
The active ingredient may be a component that corresponds to the components (A) to (D), or may not correspond to these components.

Examples of moisturizing ingredients include polyhydric alcohols such as glycerin, propanediol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, polyethylene glycol, diglycerin, trehalose, inositol, and sorbitol; polymeric compounds such as collagen, elastin, keratin, chitin, chitosan, fucoidan, and hyaluronic acids; amino acids such as glycine, aspartic acid, and arginine; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidone carboxylate; lipids such as ceramide, cholesterol, and phospholipids; and plant extracts such as chamomile extract, witch hazel extract, tea extract, lemon extract, Centella asiatica extract, artichoke extract, lemon extract, and grapefruit extract.

Anti-inflammatory ingredients include ingredients derived from plants (e.g., comfrey), zinc oxide, pyridoxine hydrochloride, tocopherol acetate, salicylic acid or its derivatives, and ε-aminocaproic acid.

Antibacterial ingredients include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, etc.

Vitamins include vitamin E such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate; vitamin B2 such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, and riboflavin tetranicotinate; dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, and nicotinic acid. nicotinic acids such as 1-(4-methylphenyl)ethyl; vitamin Cs such as ascorbigen-A, ascorbyl stearate, ascorbyl palmitate, and L-ascorbyl dipalmitate; vitamin Ds such as methylhesperidin, ergocalciferol, and cholecalciferol; vitamin Ks such as phylloquinone and farnoquinone, γ-oryzanol, dibenzoylthiamine, and dibenzoylthiamine hydrochloride; thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, and thiamine monophosphate, Vitamin B1 such as thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, and thiamine triphosphate monophosphate; vitamin B6 such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, and pyridoxamine hydrochloride; vitamin B12 such as cyanocobalamin, hydroxocobalamin, and deoxyadenosylcobalamin; folic acids such as folic acid and pteroylglutamic acid; nicotinic acid, These include nicotinic acids such as cotinamide; pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthesaine, D-pantethine, coenzyme A, and pantothenyl ethyl ether; biotins such as biotin and bioticin; ascorbic acid derivatives of vitamin C such as ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbyl phosphate, and magnesium ascorbyl phosphate; and vitamin-like factors such as carnitine, ferulic acid, α-lipoic acid, and orotic acid.

Examples of peptides or derivatives thereof include keratin hydrolyzed peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin hydrolyzed peptides, collagen hydrolyzed peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolyzed peptides, conchiolin hydrolyzed peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy proteolytic peptides, hydrolyzed soy protein, wheat protein, wheat proteolytic peptides, hydrolyzed wheat protein, casein hydrolyzed peptides, and acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.).

Examples of amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, etc.

Cell activation ingredients include amino acids such as γ-aminobutyric acid and ε-aminopropionic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids; α-hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponin, allantoin, and photosensitizer No. 301.

Anti-aging ingredients include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, etc.

Examples of blood circulation-promoting ingredients include ingredients derived from plants (e.g., ginseng, angelica, arnica, ginkgo, fennel, emmeisou, Dutch oak, chamomile, Roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake mushroom, European hawthorn, European juniper, cnidium rhizome, swertia britannica, thyme, clove, tangerine peel, angelica tree, peach kernel, spruce, carrot, garlic, butcher's broom, grape, peony, horse chestnut, melissa, yuzu, coix seed, rosemary, rose hip, peach, apricot, walnut, corn); glucosyl hesperidin, etc.

Examples of keratin softening ingredients include salicylic acid, glycolic acid, fruit acid, phytic acid, and sulfur.

Examples of whitening ingredients include tocopherol.

Anti-wrinkle ingredients include retinol, retinal, retinoic acid, and derivatives or salts thereof, harpagophytum root extract, ascorbic acid and derivatives or salts thereof, hyaluronic acid and salts thereof, collagen, hydrolyzed collagen, elastin, hydrolyzed collagen, hydrolyzed soy protein, rice fermentation liquid, placenta, yuzu ceramide, proteoglycan, Scutellaria root extract, bilberry leaf extract, artichoke extract, etc.

Examples of astringent ingredients include zinc paraphenolsulfonate, zinc oxide, menthol, ethanol, saxifrage extract, rosemary extract, and witch hazel extract.

The active ingredients may be used alone or in combination of two or more.

The mask composition may also contain pharma- ceutical or physiologically acceptable additives used in topical drugs, quasi-drugs, cosmetics, etc. Such additives may include, for example, surfactants, antioxidants, preservatives, thickeners, pH adjusters, buffers, isotonicity agents, thickeners or viscosifiers, oils, stabilizers, irritation reducers, colorants, fragrances, chelating agents, solubilizers, etc.

In the present invention, even if such additives are included, the functions of the above components (A) to (D) can be effectively exhibited.

The additive may be a component that corresponds to components (A) to (D), or it may be a component that does not correspond to these components.

Examples of surfactants include nonionic surfactants. Specific surfactants (nonionic surfactants) include, for example, polyglyceryl-2 oleate, polyglyceryl-10 pentaoleate, polyglyceryl-10 laurate, polyglyceryl-10 myristate, polyglyceryl-10 stearate, polyglyceryl-10 isostearate, polyglyceryl-10 oleate, polyglyceryl-10 distearate, polyglyceryl-10 diisostearate, polyglyceryl-10 tristearate, polyglyceryl-10 trioleate, polyglyceryl-10 pentastearate, polyglyceryl-10 pentahydroxystearate, polyglyceryl-10 pentaisostearate. Polyglyceryl-10, polyglyceryl pentaoleate, polyglyceryl-10 decaoleate, polyglyceryl-2 stearate, polyglyceryl-2 isostearate, polyglyceryl-6 myristate, polyglyceryl-6 laurate, polyglyceryl-6 stearate, polyglyceryl-6 tristearate, polyglyceryl-6 pentastearate, polyglyceryl-4 oleate, polyglyceryl-6 stearate, and other polyglyceryl fatty acid esters; PEG-5 hydrogenated castor oil, PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, P PEG [polyethylene glycol or polyoxyethylene (POE)] hydrogenated castor oils (POE hydrogenated castor oils) such as EG-100 hydrogenated castor oil; POE castor oils such as POE castor oil 3, POE castor oil 4, POE castor oil 6, POE castor oil 7, POE castor oil 10, POE castor oil 13.5, POE castor oil 17, POE castor oil 20, POE castor oil 25, POE castor oil 30, POE castor oil 35, and POE castor oil 50; sorbitan sesquioleate, sorbitan laurate, sorbitan palmitate, sorbitan stearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan isostearate, sesquioleate, sorbitan laurate, sorbitan palmitate, sorbitan ... Sorbitan fatty acid esters such as sorbitan isostearate, sorbitan oleate, and sorbitan trioleate; polysorbates (POE sorbitan fatty acid esters) such as POE(20) sorbitan monolaurate (polysorbate 20), POE(20) sorbitan monopalmitate (polysorbate 40), POE(20) sorbitan monostearate (polysorbate 60), POE(20) sorbitan tristearate (polysorbate 65), POE(20) sorbitan monooleate (polysorbate 80), and POE(20) sorbitan trioleate (polysorbate 85); POE POP glycol (196 E.O. ) (67 P.O.) (or polyoxyethylene (196) polyoxypropylene (67) glycol, the same applies below in the same expressions, poloxamer 407), POEPOP glycol (20 E.O.) (20 P.O.), POEPOP glycol (42 E.O.) (67 P.O.) (poloxamer 403), POEPOP glycol (54 E.O.) (39 P.O.) (poloxamer 235), POEPOP glycol (124 E.O.) (39 POE POP glycols such as POEPOP glycol (160 E.O.) (30 P.O.), POEPOP glycol (200 E.O.) (70 P.O.), POEPOP glycol (30 E.O.) (150 P.O.) (Poloxamer 188); polyethylene glycol monostearate (2 E.O.), polyethylene glycol monostearate (4 E.O.), polyethylene glycol monostearate (9 E.O.), and polyethylene glycol monostearate (10 E.O.); Examples of polyethylene glycol monostearate include polyethylene glycol monostearate (10 E.O.), polyethylene glycol monostearate (23 E.O.), polyethylene glycol monostearate (25 E.O.), polyethylene glycol monostearate (32 E.O.), polyethylene glycol monostearate (40 E.O., polyoxyl 40 stearate), polyethylene glycol monostearate (45 E.O.), polyethylene glycol monostearate (55 E.O.), polyethylene glycol monostearate (75 E.O.), and polyethylene glycol monostearate (140 E.O.); POE alkyl ethers such as POE (9) lauryl ether; POE-POP alkyl ethers such as POE (20) POP (4) cetyl ether; and POE alkyl phenyl ethers such as POE (10) nonylphenyl ether. In the above-listed compounds, POE is polyoxyethylene, POP is polyoxypropylene, and the numbers in parentheses indicate the number of moles added.

Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, and L-cysteine hydrochloride.

Examples of preservatives (conservatives) include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorhexidine gluconate, alkanediols, and glycerin fatty acid esters.

Examples of thickening agents include guar gum, locust bean gum, carrageenan, xanthan gum, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylate/alkyl methacrylate copolymer, polyethylene glycol, bentonite, (hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymer, (ammonium acryloyldimethyltaurate/vinylpyrrolidone) copolymer, etc.

Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.), and organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.).

Examples of buffers include boric acid buffers, phosphate buffers, carbonate buffers, citrate buffers, and acetate buffers.

Examples of isotonicity agents include sodium chloride, potassium chloride, calcium chloride, magnesium chloride, potassium acetate, sodium acetate, magnesium sulfate, glycerin, and propylene glycol.

Examples of thickening or viscosifying agents include guar gum, hydroxypropyl guar gum, cellulose-based polymer compounds (e.g., methylcellulose, ethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, etc.), gum arabic, karaya gum, xanthan gum, agar, alginic acid, α-cyclodextrin, dextrin, dextran, mucopolysaccharides (e.g., heparinoids, heparin, heparin sulfate, heparan sulfate, heparinoid, hyaluronic acid, hyaluronate (sodium salt, etc.), etc.), starch, chitin and its derivatives, chitosan and its derivatives, carrageenan, sorbitol ... Examples include tallow, polyvinyl polymer compounds (polyvinylpyrrolidone, polyvinyl alcohol, carboxyvinyl polymer, etc.), alkali metal salts of polyacrylic acid (sodium salt, potassium salt, etc.), amine salts of polyacrylic acid (monoethanolamine salt, diethanolamine salt, triethanolamine salt, etc.), casein, gelatin, collagen, pectin, elastin, ceramide, liquid paraffin, glycerin, polyethylene glycol, macrogol, polyethyleneimine alginate (sodium salt, etc.), alginate esters (propylene glycol ester, etc.), powdered tragacanth, and triisopropanolamine.

Oils include hydrocarbon oils (e.g., liquid paraffin, liquid isoparaffin, squalane, squalene, α-olefin oligomers), fats and oils (e.g., vegetable oils [e.g., soybean oil, rapeseed oil, corn oil, sesame oil, linseed oil, safflower oil, sunflower oil, cottonseed oil, nut oils (macadamia nut oil, hazelnut oil, peanut oil, almond oil, walnut oil, etc.), seed oils (grape seed oil, pumpkin seed oil, etc.), lemon oil, camellia oil, tea seed oil, perilla oil, borage oil, olive oil, rice oil, rice bran oil, wheat germ oil, coconut oil, palm oil, palm olein, palm kernel oil, etc.], animal oils (e.g., fish oil, liver oil, whale oil, etc.), medium-chain triglycerides, dimethyl tert-butyl ether (MCT), etc.}, ester oils {for example, adipate esters (for example, diisobutyl adipate, di-2-ethylhexyl adipate, dibutyl adipate), isooctanoate esters [for example, glycerin triisooctanoate (triisooctanoic acid glyceride)], isononanoate esters (for example, isononyl isononanoate), myristate esters (for example, isopropyl myristate), isostearate esters (for example, batyl isostearate), sebacate esters (for example, diethyl sebacate), etc.}, silicone oils, fatty acids (for example, isostearic acid, etc.), higher alcohols, etc.

Examples of stabilizers include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole, and sodium pyrosulfite.

Examples of irritation reducers include licorice extract and sodium alginate.

Examples of coloring agents include the dyes listed in the Legal Dyes Handbook (edited by the Japan Cosmetic Industry Association (2004) etc.).

Fragrances include, for example, various essential oils such as herbal essential oils, such as lavender oil, rosemary oil, clary sage oil, thyme oil, bergamot oil, and eucalyptus oil; mint essential oils, such as peppermint oil, spearmint oil, and peppermint oil; citrus essential oils, such as orange oil, lemon oil, and grapefruit oil; and blended fragrances.

Chelating agents include EDTA disodium salt and EDTA calcium disodium salt.

The additives may be used alone or in combination of two or more.

The form of the mask composition is not particularly limited, but may be, for example, a sol or gel. The mask composition can be produced, for example, by mixing the components according to or in accordance with the General Provisions of the Japanese Pharmacopoeia.

The mask formulation can be applied to human skin without any particular limitations, but is preferably used on the entire face.

<Mask preparation kit>
The mask formulation kit of this embodiment includes a nonwoven fabric and a mask composition. The nonwoven fabric and the mask composition are the same as those described above, so the overlapping descriptions will not be repeated. The mask formulation kit can be used in the same manner as the above-mentioned mask formulation after impregnating the nonwoven fabric with the mask composition. In addition, the mask formulation kit may be a multi-pack in which multiple mask formulations are bundled together, or may be a mask formulation individually packaged one by one.

The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these.

<Samples 1 to 8>
Each mask composition (samples 1 to 8) having the composition shown in Table 1 was prepared in a conventional manner. Note that the "appropriate amount" in Table 1 refers to the amount required to adjust the pH of the mask composition to the value shown in Table 1.

The viscosity of the mask compositions of samples 1 to 8 was measured using a VISCOMETER TV-10 (manufactured by Toki Sangyo Co., Ltd.). The viscosity measurement conditions were a rotor of M4, a rotation speed of 12 rpm, and a rotation time of 60 seconds. Although it was not possible to measure the viscosity of samples 5 and 8 under the above conditions, it is estimated to be about the same as that of water (around 1 mPa·s, at most 10 mPa·s or less).

In addition, for each of the mask compositions samples 1 to 8, the L value of the cosmetic in the Lab color system was measured by placing it in a glass cell (CM-A99, thickness 20 mm) and using a spectrophotometer CM-5 (manufactured by Konica Minolta, Inc.).

<Evaluation Test of Samples 1 to 8>
The above-mentioned Samples 1 to 8 (mask compositions) or mask preparations containing them were subjected to the following evaluation tests (sensory test, liquid retention test, and preservative test).

[Sensory Test]
A nonwoven fabric (SE603, Bemliese (registered trademark) 60 basis weight) was cut to a size of 2 cm x 2 cm, and 8 times the weight (0.192 g) of the nonwoven fabric (0.024 g) of the mask composition (each of samples 1 to 8) was impregnated to prepare each mask preparation. The usability (adhesion, penetration, irritation, lack of squeaking) of each of the samples was evaluated on a scale of 1 to 5 by three subjects. Note that a higher score indicates a higher usability (adhesion, penetration, irritation, lack of squeaking). The average evaluation results are shown in Table 1.

As shown in Table 1, when tranexamic acid was added to a conventional mask (mask formulation using sample 8) (samples 5 and 6), squeaking increased (less squeaking decreased). However, by making this into a jelly mask with tranexamic acid and increased viscosity (samples 1 to 4), squeaking was suppressed (less squeaking improved). Furthermore, by making the conventional masks containing tranexamic acid (samples 5 and 6) into jelly masks with tranexamic acid and increased viscosity (samples 1 to 4), the feeling of adhesion and penetration was also improved.

[Liquid retention test]
A nonwoven fabric (SE603, Bemliese 60 basis weight) was cut to a size of 5 cm x 5 cm, and impregnated with 8 times the weight (1.2 g) of the nonwoven fabric (0.15 g) of the mask composition (each of samples 1 to 8) to prepare each mask preparation. Each mask preparation was left to stand in a thermostatic bath at 70°C, and the mass of the mask composition remaining in the mask preparation after 10 minutes was measured, and the ratio of the mass of the mask composition after 10 minutes to the initial mass of the mask composition (liquid retention rate) was calculated. The ratio of the liquid retention rate of the other preparations to the liquid retention rate of the mask preparation using sample 8 (conventional mask) set to 1 is shown in the column of liquid retention in Table 2.

As shown in Table 2, the jelly mask (sample 7) has higher liquid retention than the mask alone (sample 8), but it can be seen that adding tranexamic acid to the viscosity-enhancing mask further improves liquid retention (samples 1 and 2). On the other hand, adding tranexamic acid to the mask alone (sample 8) does not change the liquid retention (sample 5), and slightly increasing the viscosity to less than 3000 mPa·s actually reduces the liquid retention (sample 6). From this, it is thought that the effect of tranexamic acid in improving liquid retention is unique to jelly masks with high viscosity (for example, 3000 mPa·s or more).

[Anti-corrosive power test]
The mask compositions of Samples 1, 2, 4, 5, 6 and 8 and the mask compositions of Samples 1, 7 and 8 were subjected to a preservative test by the direct inoculation method.

Specifically, each mask composition was inoculated with the bacterial liquid to a concentration of about 10 ⁵ CFU/mL, and 24 hours after ingestion of the bacterial liquid, each mask composition was diluted and the viable bacteria count was measured by the agar plate surface smear method. The viable bacteria count was measured in accordance with the 17th Bureau's "4.05 Microbial Limit Test Method, Agar Plate Surface Smear Method." Two types of test bacteria were used in the bacterial liquid: Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 8739). The results of the viable bacteria count measurement are shown in Tables 3 and 4. The viable bacteria count immediately after inoculation is as shown in Tables 3 and 4.

As shown in Table 3, when tranexamic acid was added to the conventional mask (sample 8) (samples 5 and 6), no significant change in preservative power was observed. In contrast, as shown in Table 4, when tranexamic acid was added to the jelly mask (sample 7) (sample 1), the preservative power was significantly improved. Note that, also in Table 3, when the jelly masks containing tranexamic acid (samples 1, 2, and 4) were used, the preservative power was significantly improved compared to the conventional mask containing tranexamic acid and the conventional mask. Due to the dramatic improvement in preservative power, the mask formulation of the present invention can maintain its preservative power for a certain period of time even when used in a multipack containing multiple masks, in addition to individual packaging intended for single use, making it possible to provide a mask formulation of good quality.

<Samples 11 to 17>
Each mask composition (samples 11 to 17) having the composition shown in Table 5 was prepared in a conventional manner. Note that the "appropriate amount" in Table 5 is the amount required to adjust the pH of the mask composition.

The viscosity of the mask compositions of samples 11 to 17 was measured using a VISCOMETER TV-10 (manufactured by Toki Sangyo Co., Ltd.). The viscosity measurement conditions were a rotor of M4, a rotation speed of 12 rpm, and a rotation time of 60 seconds. Although it was not possible to measure the viscosity of samples 15 and 17 under the above conditions, it is estimated to be about the same as that of water (around 1 mPa·s, at most 10 mPa·s or less).

<Evaluation Tests of Samples 11 to 17>
The above-mentioned Samples 11 to 17 (mask compositions) or mask preparations containing them were subjected to the following evaluation tests (liquid retention test, preservative power test).

[Liquid retention test]
A nonwoven fabric (SE603, Bemliese 60 basis weight) was cut to a size of 5 cm x 5 cm, and impregnated with 8 times the weight (1.2 g) of the nonwoven fabric (0.15 g) of the mask composition (each of Samples 11 to 17) to prepare each mask preparation. Each mask preparation was left to stand in a thermostatic bath at 70°C, and the mass of the mask composition remaining in the mask preparation after 10 minutes was measured, and the ratio of the mass of the mask composition after 10 minutes to the initial mass of the mask composition (liquid retention rate) was calculated. The ratio of the liquid retention rate of the other preparations to the liquid retention rate of the mask preparation using Sample 17 (conventional mask) set to 1 is shown in the column of liquid retention in Table 6.

As shown in Tables 6 and 7, it can be seen that the liquid retention is further improved when nicotinamide is added to the jelly mask (Sample 11, 13) compared to the mask alone (Sample 17). Also, the liquid retention is further improved when the jelly mask is used (Sample 12) compared to the mask containing nicotinamide (Sample 15).

[Anti-corrosive power test]
The mask compositions of Samples 14 to 17 were subjected to a preservative test by the direct inoculation method.

Specifically, each mask composition was inoculated with a bacterial solution to a concentration of about 10 ⁵ CFU/mL, and 24 hours after ingestion of the bacterial solution, each mask composition was diluted and the viable bacteria count was measured by the agar plate surface smear method. The viable bacteria count was measured in accordance with the 17th Bureau's "4.05 Microbial Limit Test Method, Agar Plate Surface Smear Method." Three types of test bacteria were used in the bacterial solution: Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 8739), and Candida albicans (ATCC 10231). The results of the viable bacteria count measurement are shown in Table 7. The viable bacteria count immediately after inoculation is as shown in Table 7.

As shown in Tables 8 to 10, when nicotinamide was added to the conventional mask (sample 17) and jelly mask (sample 16) (samples 11 to 14), the preservative power was significantly improved. Due to the dramatic improvement in preservative power, the mask formulation of the present invention can maintain its preservative power for a certain period of time even when used in a multi-pack containing multiple masks in addition to individual packaging intended for single use, making it possible to provide a mask formulation of good quality.

<Nonwoven fabric characteristic test>
The following property tests were carried out on several types of nonwoven fabric made of the materials shown in Table 11. The values in the "Material" column in Table 11 indicate the content (mass%) of each material in the material.

Specifically, each nonwoven fabric was cut to a size of 2 cm x 2 cm and impregnated with 8 times the weight of the mask composition (sample 1) as the nonwoven fabric to obtain a mask preparation. Each mask preparation obtained was visually observed and rated on a scale of 1 to 5 for impregnation, twisting, and adhesion. A higher score indicates better impregnation, twisting, and adhesion. The evaluation results are shown in Table 11.

As shown in Table 11, based on the comparison with Bemliese (registered trademark) and the results of other materials, it is believed that a mask preparation with good impregnation and little twisting can be obtained when a nonwoven fabric with a basis weight of 40 to 80 g/m ² is used. Note that Bemliese is a cupra long fiber nonwoven fabric (manufactured by Asahi Kasei Corporation) made from cotton linters.

[Prescription example]
Formulation examples of the mask compositions used in the mask preparation of the present invention are shown in the following Tables 12 to 20. The numerical values of each component in the tables indicate the blending ratio (unit: mass %) in the composition.

The embodiments and examples disclosed herein should be considered to be illustrative and not restrictive in all respects. The scope of the present invention is indicated by the claims rather than the above description, and is intended to include all modifications within the meaning and scope of the claims.

Claims (4)

A nonwoven fabric having a basis weight of 40 g/m ² to 80 g/m ² ;
A mask composition impregnated into the nonwoven fabric,
The mask composition comprises:
(A) 0.5% by mass or more of a water-soluble active ingredient having a log P value of 0 or less and a molecular weight of 1,000 or less;
(B) 60% by mass or more of at least one of water and a lower alcohol,
(C) 5 % by mass or more and less than 25 % by mass of a polyol;
(D) at least one polymer compound,
The active ingredient is at least one of tranexamic acid and nicotinamide,
the polyol is at least one of butylene glycol and 1,3-propanediol;
the at least one polymer compound is at least one of a carboxyvinyl polymer and an acrylic acid/alkyl methacrylate copolymer;
When the active ingredient contains tranexamic acid, the content of tranexamic acid in the mask composition is 1 to 5% by mass,
When the active ingredient contains nicotinamide, the content of nicotinamide in the mask composition is 3 to 7% by mass,
A mask formulation, wherein the viscosity of the mask composition is 3000 mPa·s or more. The mask formulation according to claim 1 , wherein the viscosity of the mask composition is 3,000 to 30,000 mPa·s. The mask preparation according to claim 1 or 2 , wherein the L value of the cosmetic material of the mask composition in the Lab color system is 50 to 100. A nonwoven fabric having a basis weight of 40 g/m ² to 80 g/m ² ;
A mask formulation kit comprising:
The mask composition comprises:
(A) 0.5% by mass or more of a water-soluble active ingredient having a log P value of 0 or less and a molecular weight of 1,000 or less;
(B) 60% by mass or more of at least one of water and a lower alcohol,
(C) 5 % by mass or more and less than 25 % by mass of a polyol;
(D) at least one polymer compound,
The active ingredient is at least one of tranexamic acid and nicotinamide,
the polyol is at least one of butylene glycol and 1,3-propanediol;
the at least one polymer compound is at least one of a carboxyvinyl polymer and an acrylic acid/alkyl methacrylate copolymer;
When the active ingredient contains tranexamic acid, the content of tranexamic acid in the mask composition is 1 to 5% by mass,
When the active ingredient contains nicotinamide, the content of nicotinamide in the mask composition is 3 to 7% by mass,
The mask formulation kit, wherein the viscosity of the mask composition is 3000 mPa·s or more.