JP6836017B2 - Topical skin composition - Google Patents

Description

The present invention relates to a composition for external use on the skin. More specifically, the present invention relates to an external composition for skin containing nicotinamide.

Nicotinamide is one of the vitamins, and has been used as a component for promoting blood circulation, anti-inflammatory, ceramide synthesis, etc. in the skin care field, and further for whitening, anti-wrinkle, and anti-aging. It is also known to have an effect.

For example, Patent Document 1 proposes a whitening agent containing at least one selected from the group consisting of riboflavin, pyridoxine hydrochloride, nicotinamide and calcium pantothenate as an active ingredient.

Further, Patent Document 2 is characterized by containing (a) nicotinamide, (b) urea, and one or more selected from the group consisting of α-hydroxycarboxylic acid compounds having 2 to 28 carbon atoms. Skin anti-aging cosmetics have been proposed.

Japanese Unexamined Patent Publication No. 2004-217629 Japanese Unexamined Patent Publication No. 10-130135

Cosmetics and the like generally contain preservatives as well as active ingredients and the like. The present inventors have found a novel problem that, particularly when an organic acid or an amphipathic component is blended with a preservative, precipitation does not occur with each component alone.

An object of the present invention is to provide a composition for external use on the skin in which precipitation is suppressed even in a composition containing a preservative and an organic acid or an amphipathic component.

As a result of diligent studies to solve the above problems, the present inventors have found that precipitation caused by a combination of a preservative and an organic acid or an amphipathic component can be suppressed by adding nicotinamide. Has been completed.

（式中、
Ｚは、水素原子、又は、炭素数１〜３０のヒドロキシ化合物からｎ個のヒドロキシ基を除去することによって得られる残基を意味し；
ＡＯは、３〜４個の炭素原子を有するオキシアルキレン基を意味し；
ＥＯは、オキシエチレン基を意味し；
ＢＯは、４個の炭素原子を有するオキシアルキレン基を意味し；
ｎは、１〜９を意味し；
ａ，ｂ及びｃは、それぞれＡＯ、ＥＯ、ＢＯの平均付加モル数を意味し、独立して０〜２００である。但し、ａ、ｂ及びｃが全て０になることはない。また、ｎが２以上の時、複数のａ、ｂ及びｃはそれぞれ同一でも異なってもよい。Ｚが水素原子の時は、ｎは１である。
なお、ＡＯ及びＥＯは、ランダムに又はブロックの形態で付加されていてよい。）
項４.
前記（Ｃ）成分が、下記一般式（ＩＩ）で表される化合物、２−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体、（エイコサン二酸／テトラデカン二酸）デカグリセリル、シクロヘキサンジカルボン酸ビスエトキシジグリコール、コハク酸ジエチルヘキシル、コハク酸ジエトキシエチル、及び、炭素数５〜１０のアルカンジオールからなる群より選ばれる１種又は２種以上である、項１〜３のいずれか１項に記載の皮膚外用組成物：

（式中、
Ｚは、水素原子、又は、炭素数１〜３０のヒドロキシ化合物からｎ個のヒドロキシ基を除去することによって得られる残基を意味し；
ＡＯは、３〜４個の炭素原子を有するオキシアルキレン基を意味し；
ＥＯは、オキシエチレン基を意味し；
ｎは、１〜９を意味し；
ａ及びｂは、それぞれＡＯ、ＥＯの平均付加モル数を意味し、独立して０〜２００である。但し、ａ及びｂが全て０になることはない。また、ｎが２以上の時、複数のａ、ｂはそれぞれ同一でも異なってもよい。Ｚが水素原子の時はｎは１である。
なお、ＡＯ及びＥＯは、ランダムに又はブロックの形態で付加されていてよい。）
項５.
前記一般式（Ｉ）及び（ＩＩ）において、Ｚが、水素原子であるか、若しくは、炭素数４〜２４のアルキルモノアルコール、グリセリン、トリメチロールプロパン、エリスリトール、ペンタエリスリトール、炭素数１〜２４のアルキルグルコシド、ジグリセリン、キシリトール、ジペンタエリスリトール、ソルビトール、イノシトール、スクロース、トレハロース、又は、マルチトールからｎ個のヒドロキシ基を除去することによって得られる残基である、項３又は４に記載の皮膚外用組成物。
項６.
前記一般式（Ｉ）及び（ＩＩ）において、Ｚが、水素原子であるか、若しくは、炭素数４〜２４のアルキルモノアルコール、グリセリン、炭素数１〜２４のアルキルグルコシド、又は、ジグリセリンからｎ個のヒドロキシ基を除去することによって得られる残基である、項３又は４に記載の皮膚外用組成物。
項７.
前記（Ｂ）成分が、パラオキシ安息香酸エステル、安息香酸、安息香酸塩、デヒドロ酢酸、デヒドロ酢酸塩、チモール、イソプロピルメチルフェノール、カプリルヒドロキサム酸、ブチルカルバミン酸ヨウ化プロピニル、ブチルカルバミン酸ヨウ化プロピニルの塩、ブチルカルバミン酸ヨウ化プロピニル誘導体、ソルビン酸、ソルビン酸塩、クロロブタノール、及びメチルイソチアゾリンからなる群より選択される少なくとも１種である、項１〜６のいずれか１項に記載の皮膚外用組成物。
項８．
さらに、紫外線吸収剤を含有する、項１〜７のいずれか１項記載の皮膚外用組成物。
項９．
前記紫外線吸収剤の総含有量が２０質量％以下である、項８記載の皮膚外用組成物。
項１０．
さらに、紫外線防御剤を含有する、項１〜９のいずれか１項記載の皮膚外用組成物。
項１１．
前記紫外線吸収剤がサリチル酸系紫外線吸収剤、ケイ皮酸系紫外線吸収剤、ベンゾイルメタン系紫外線吸収剤、安息香酸エステル誘導体紫外線吸収剤、トリアジン誘導体紫外線吸収剤、ベンザルマロナート誘導体紫外線吸収剤、オクトクリレン系紫外線吸収剤、イミダゾ-ルスルホン酸誘導体紫外線吸収剤、及びベンゾフェノン誘導体紫外線吸収剤からなる群より選択される１種以上である、項１〜１０のいずれか１項記載の皮膚外用組成物。
項１２．
前記紫外線吸収剤がパラメトキシケイ皮酸２−エチルヘキシル、４−ｔｅｒｔ−ブチル−４’−メトキシジベンゾイルメタン、２−［４−（ジエチルアミノ）−２−ヒドロキシベンゾイル］安息香酸ヘキシルエステル、２，４−ビス−［｛４−（２−エチルヘキシルオキシ）−２−ヒドロキシ｝−フェニル］−６−（４−メトキシフェニル）−１，３，５−トリアジン、２，４，６−トリス［４−（２−エチルヘキシルオキシカルボニル）アニリノ］−１，３，５−トリアジン、２−フェニルベンゾイミダゾ−ル−５−スルホン酸からなる群より選択される１種以上である、項１〜１１のいずれか１項記載の皮膚外用組成物。
項１３．
さらに、美白成分を０．００１〜１０質量％含有する、項１〜１２のいずれか１項記載の皮膚外用組成物。
項１４．
さらに、抗炎症成分を０．００１〜５質量％含有する、項１〜１３のいずれか１項記載の皮膚外用組成物。
項１５．
さらに、酸性ムコ多糖類を含有する、項１〜１４のいずれか１項記載の皮膚外用組成物。
項１６．
さらに、油分、界面活性剤、及び増粘剤からなる群より選択される１種又は２種以上を含有する、項１〜１５のいずれか１項記載の皮膚外用組成物。That is, the present invention provides the following external composition for skin.
Item 1.
(A) Nicotinamide 3% by mass or more;
An external composition for skin containing (B) a preservative; and (C) at least one selected from the group consisting of organic acids, organic acid salts, derivatives of organic acids, and amphipathic compounds.
Item 2.
The component (C) is
Tranexamic acid or its salt, lactic acid or its salt, citric acid or its salt, succinic acid or its salt, salicylic acid or its salt, gluconic acid or its salt, phytic acid or its salt, tartrate or its salt, ascorbic acid phosphate Item 2. The item 1, which is at least one selected from the group consisting of sodium, ascorbic acid phosphate magnesium, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, and ascorbic acid-2-glucoside. External composition for skin.
Item 3.
One or two components (C) selected from the group consisting of a compound represented by the following general formula (I), a phosphorylcholine-containing polymer, a divalent carboxylic acid ester, and an alkanediol having 5 to 10 carbon atoms. Item 2. The external composition for skin according to Item 1 or 2.

(During the ceremony
Z means a residue obtained by removing n hydroxy groups from a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms;
AO means an oxyalkylene group having 3-4 carbon atoms;
EO means oxyethylene group;
BO means an oxyalkylene group having 4 carbon atoms;
n means 1-9;
a, b and c mean the average number of moles added of AO, EO and BO, respectively, and are 0 to 200 independently. However, a, b and c are not all 0. Further, when n is 2 or more, the plurality of a, b and c may be the same or different. When Z is a hydrogen atom, n is 1.
AO and EO may be added randomly or in the form of blocks. )
Item 4.
The component (C) is a compound represented by the following general formula (II), 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, (eicosandioic acid / tetradecanedioic acid) decaglyceryl, cyclohexanedicarboxylic acid bisethoxy. Item 6. The item 1 to any one of Items 1 to 3, which is one or more selected from the group consisting of diglycol, diethylhexyl succinate, diethoxyethyl succinate, and alkanediol having 5 to 10 carbon atoms. External composition of skin:

(During the ceremony
Z means a residue obtained by removing n hydroxy groups from a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms;
AO means an oxyalkylene group having 3-4 carbon atoms;
EO means oxyethylene group;
n means 1-9;
a and b mean the average number of moles added of AO and EO, respectively, and are independently 0 to 200. However, a and b are not all 0. Further, when n is 2 or more, the plurality of a and b may be the same or different. When Z is a hydrogen atom, n is 1.
AO and EO may be added randomly or in the form of blocks. )
Item 5.
In the general formulas (I) and (II), Z is a hydrogen atom, or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, trimethylolpropane, erythritol, pentaerythritol, and having 1 to 24 carbon atoms. Item 3. The skin according to Item 3 or 4, which is a residue obtained by removing n hydroxy groups from alkyl glucoside, diglycerin, xylitol, dipentaerythritol, sorbitol, inositol, sucrose, trehalose, or maltitol. External composition.
Item 6.
In the general formulas (I) and (II), Z is a hydrogen atom or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, an alkyl glucoside having 1 to 24 carbon atoms, or from diglycerin to n. Item 3. The external composition for skin according to Item 3 or 4, which is a residue obtained by removing the hydroxy groups.
Item 7.
The component (B) is paraoxybenzoic acid ester, benzoic acid, benzoate, dehydroacetic acid, dehydroacetate, timol, isopropylmethylphenol, caprylhydroxamic acid, propynyl butylcarbamate iodide, propynyl iodide butylcarbamic acid. Item 2. The external use for skin according to any one of Items 1 to 6, which is at least one selected from the group consisting of a salt, a propynyl iodide butylcarbamic acid derivative, a sorbic acid, a sorbate, a chlorobutanol, and a methylisothiazolin. Composition.
Item 8.
The external composition for skin according to any one of Items 1 to 7, further comprising an ultraviolet absorber.
Item 9.
Item 8. The external composition for skin according to Item 8, wherein the total content of the ultraviolet absorber is 20% by mass or less.
Item 10.
The external composition for skin according to any one of Items 1 to 9, further comprising an ultraviolet protective agent.
Item 11.
The UV absorbers are salicylic acid-based UV absorber, silicic acid-based UV absorber, benzoylmethane-based UV absorber, benzoic acid ester derivative UV absorber, triazine derivative UV absorber, benzalmalonate derivative UV absorber, octoclilen. Item 2. The composition for external use on the skin according to any one of Items 1 to 10, which is one or more selected from the group consisting of a system ultraviolet absorber, an imidazole sulfonic acid derivative ultraviolet absorber, and a benzophenone derivative ultraviolet absorber.
Item 12.
The ultraviolet absorbers are 2-ethylhexyl paramethoxysilicate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4. -Bis- [{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine, 2,4,6-tris [4-( 2-Ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, 2-phenylbenzoimidazole-5-sulfonic acid is one or more selected from the group, any one of Items 1 to 11. The composition for external use on the skin according to the section.
Item 13.
The external composition for skin according to any one of Items 1 to 12, further comprising 0.001 to 10% by mass of a whitening component.
Item 14.
The external composition for skin according to any one of Items 1 to 13, further comprising 0.001 to 5% by mass of an anti-inflammatory component.
Item 15.
Item 2. The external composition for skin according to any one of Items 1 to 14, further comprising an acidic mucopolysaccharide.
Item 16.
Item 2. The external composition for skin according to any one of Items 1 to 15, further comprising one or more selected from the group consisting of an oil, a surfactant, and a thickener.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a composition for external use on the skin in which precipitation is suppressed.

In the present specification, the unit of content "mass%" is synonymous with "g / 100g".

The external composition for skin of the present invention is
(A) Nicotinamide;
A composition for external use on the skin containing (B) a preservative; and (C) at least one selected from the group consisting of organic acids, organic acid salts, derivatives of organic acids, and amphipathic compounds.

[(A) Nicotinamide]
Nicotinamide included in the external composition for skin of the present invention, an amide compound of nicotinic acid (vitamin B _{3 /} niacin), a water-soluble vitamins. The nicotinamide may be an extract from a natural product or a product synthesized by a known method. Specifically, the ones listed in the 17th revised Japanese Pharmacopoeia can be used. It is known to have a blood circulation promoting effect, a rough skin improving effect, a melanin production suppressing effect, and a whitening effect.

In the external composition for skin of the present invention, the content of the component (A) with respect to the total amount of the composition is appropriately set depending on the balance with other components. The content of the component (A) is preferably 3% by mass or more, more preferably 4% by mass or more, from the viewpoint of sufficiently imparting effectiveness such as whitening and anti-aging to the total amount of the composition. , Even more preferably, it can be 5% by mass or more. The content of the component (A) is preferably 20% by mass or less, more preferably 15% by mass or less, still more preferably 10% by mass or less, and particularly preferably 8% by mass, based on the total amount of the composition. % Or less. The content of the component (A) is preferably 3% by mass to 20% by mass, more preferably 3% by mass to 15% by mass, and further preferably 3% by mass to 10% by mass with respect to the total amount of the composition. , Even more preferably 4% by mass to 8% by mass.

[(B) Preservative]
The preservative contained in the external composition for skin of the present invention is a compound usually used as a component of external preparation for skin in the fields of pharmaceuticals, quasi-drugs or cosmetics, and is solid at room temperature (20 ° C.) and water. It is a water-soluble preservative that can be dissolved in. In the present specification, the "water-soluble preservative" may be any preservative that can be dissolved in water even slightly. For example, it suffices if it can be dissolved in water at a ratio of 0.01% or more, preferably 0.05% or more. Examples of preservatives contained in the external composition for skin of the present invention include paraoxybenzoic acid esters (parabens) such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; benzoic acid, or Benzoate such as sodium benzoate; dehydroacetate or dehydroacetate such as sodium dehydroacetate; in addition, of timol, isopropylmethylphenol, caprylhydroxamic acid, propynyl iodide butylcarbamate, or propynyl iodide butylcarbamate. Salts or derivatives; sorbic acid, sorbate such as potassium sorbate, chlorobutanol, methylisothiazolin and the like are exemplified.

Here, as the salt of the component (B) of the present invention, alkali metal salts such as sodium and potassium are preferable. As the component (B) of the present invention, any one of these compounds or two or more of these compounds can be used, and among them, paraoxybenzoic acid ester, benzoic acid, benzoate, dehydroacetic acid, and dehydroacetate. , Isopropylmethylphenol, caprylhydroxamic acid, propynyl iodide butylcarbamate, a salt or derivative of propynyl iodide butylcarbamate, sorbic acid, sorbate, chlorobutanol, and one or more selected from the group consisting of methylisothiazolin. Preferably, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, benzoic acid, sodium benzoate, isopropylmethylphenol, caprylhydroxamic acid, propynyl iodide butylcarbamate, sorbic acid, sodium sorbate, potassium sorbate, And one or more selected from the group consisting of chlorobutanol, more preferably, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, benzoic acid, sodium benzoate, isopropylmethylphenol, caprylhydroxamic acid, iodine butylcarbamate. One or more selected from the group consisting of propynyl, sorbic acid, potassium sorbate, and chlorobutanol is more preferable, and methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, benzoic acid, caprylhydroxamic acid, and butylcarbamine. One or more selected from the group consisting of propynyl acid iodide, sorbic acid, and chlorobutanol is even more preferable, and one or more selected from the group consisting of methyl paraoxybenzoate, ethyl paraoxybenzoate, benzoic acid, and sorbic acid. Especially preferable.

These can be synthesized, or commercially available products can be used as they are. Such a component (B) is not particularly limited as a commercially available product, but for example, in addition to available reagents, Platins M, ethyl paraoxybenzoate, Platins P, butyl paraoxybenzoate (paraoxybenzoate ester) (any of them). Also manufactured by Ueno Pharmaceutical Co., Ltd.), Methyl paraoxybenzoate, Ethyl paraoxybenzoate, Propyl paraoxybenzoate (all manufactured by IP Corporation); Isopropylmethylphenol, Timor (all manufactured by Osaka Kasei Co., Ltd.), IPMP-TN (Tech) Noble Co., Ltd.) ,; Zeastat, Spectrastat E, G, etc. (Capril hydroxamic acid) (all manufactured by INOLEX); GLYCASIL, GLYCASIL2000, GLYCASIL L, GLYCASIL S (Butylcarbamate iodide propynyl) (all manufactured by Lonz) ); Chloreton (chlorobutanol) (manufactured by Sekisui Medical Co., Ltd.) or the like is used.

In the external composition for skin of the present invention, the total content of the component (B) with respect to the total amount of the composition is preferably 0.0001 to 6% by mass, more preferably 0.001 to 3% by mass, still more preferably 0. It is 01 to 1.5% by mass, more preferably 0.05 to 1% by mass, and particularly preferably 0.1 to 0.5% by mass.

In the external composition for skin of the present invention, the ratio of the total content of the component (B) to the component (A) is not particularly limited, but the component (B) is preferably 0 with respect to 1 part by mass of the component (A). It is .0001 to 2 parts by mass, more preferably 0.001 to 1 part by mass, and further preferably 0.01 to 0.5 part by mass.

In the external composition for skin of the present invention, the total content of the paraoxybenzoic acid ester with respect to the total amount of the composition is not particularly limited as long as the effects of the present invention are exhibited. The total content of the paraoxybenzoic acid ester is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, still more preferably 0.01% by mass or more, and further, based on the total amount of the composition. More preferably, it is 0.05% by mass or more, and particularly preferably 0.1% by mass or more. The content of the paraoxybenzoic acid ester is preferably 1% by mass or less, more preferably 0.7% by mass or less, still more preferably 0.5% by mass or less, still more, based on the total amount of the composition. It is preferably 0.3% by mass or less, and particularly preferably 0.2% by mass or less. The total content of the paraoxybenzoic acid ester is preferably 0.005 to 1% by mass, more preferably 0.01 to 0.5% by mass, still more preferably even more, based on the total amount of the composition. It is preferably 0.05 to 0.3% by mass, and particularly preferably 0.1 to 0.2% by mass.

In the external composition for skin of the present invention, the content of benzoic acid or sodium benzoate alone with respect to the total amount of the composition is not particularly limited as long as the effects of the present invention are exhibited. The content of benzoic acid or sodium benzoate is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, still more preferably 0.01% by mass or more, based on the total amount of the composition. Even more preferably, it is 0.05% by mass or more. The content of benzoic acid or sodium benzoate is preferably 1% by mass or less, more preferably 0.7% by mass or less, still more preferably 0.5% by mass or less, based on the total amount of the composition. Even more preferably, it is 0.3% by mass or less. The total content of benzoic acid or sodium benzoate is preferably 0.005 to 1% by mass, more preferably 0.01 to 0.5% by mass, still more preferably, based on the total amount of the composition. It is 0.05 to 0.3% by mass.

[Component (C)]
The component (C) contained in the external composition for skin of the present invention is at least one selected from the group consisting of organic acids, organic acid salts, derivatives of organic acids, and amphipathic compounds.

((C-1) Organic acid, organic acid salt, or derivative of organic acid)
As the organic acid, organic acid salt, or derivative of the organic acid used in the present invention, a compound usually used as a component of an external preparation for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics can be used.

In the present invention, the organic acid is an acid of an organic compound having an organic group and having a molecular weight of 1000 or less, preferably 700 or less, more preferably 500 or less, still more preferably 350 or less, and particularly preferably 300 or less. The organic acid is preferably a water-soluble organic acid. The organic acid may be a carboxylic acid having a carboxyl group, a sulfonic acid having a sulfo group, or a phosphoric acid ester having a phosphoric acid group. More specifically, but not limited to, organic acids include, for example, ascorbic acid, tranexamic acid, citric acid, salicylic acid, lactic acid, tartaric acid, malic acid, succinic acid, oxalic acid, gluconic acid, fumaric acid, aspartic acid. , Pyrrolidone carboxylic acid, ε-aminocaproic acid, glutamic acid, aminoethylsulfonic acid, ellagic acid, kodiic acid, glycyrrhizinic acid, glycyrrhetinic acid, phytic acid, ferulic acid, glycolic acid, azelaic acid and the like. Among them, ascorbic acid, tranexamic acid, citric acid, salicylic acid, lactic acid, tartaric acid, malic acid, succinic acid, gluconic acid, aspartic acid, pyrrolidone carboxylic acid, ε-aminocaproic acid, glutamic acid, aminoethylsulfonic acid, ellagic acid, kodiic acid, One or more selected from the group consisting of glycyrrhizinic acid, glycyrrhetinic acid, phytic acid, ferulic acid, glycolic acid, and azelaic acid is preferable, and ascorbic acid, tranexamic acid, citric acid, salicylic acid, lactic acid, tartaric acid, malic acid, One or more selected from the group consisting of succinic acid, gluconic acid, pyrrolidone carboxylic acid, ε-aminocaproic acid, glutamic acid, citric acid, glycyrrhizinic acid, glycyrrhetinic acid, phytic acid, ferulic acid, glycolic acid, and azelaic acid. More preferably, one or more selected from the group consisting of ascorbic acid, tranexamic acid, citric acid, salicylic acid, lactic acid, succinic acid, tartrate acid, gluconic acid, succinic acid, phytic acid, glycolic acid, glycyrrhizinic acid. Preferably, one or more selected from the group consisting of ascorbic acid, tranexamic acid, citric acid, lactic acid, gluconic acid, salicylic acid, tartaric acid, phytic acid, and citric acid is even more preferable, ascorbic acid, tranexamic acid, citric acid. One or more selected from the group consisting of lactic acid and lactic acid is particularly preferable.

In the present invention, the organic acid salt refers to such a salt of an organic acid. The salt forming the organic acid salt is a pharmaceutically acceptable salt. For example, but not limited to, salts with organic bases (eg, salts with tertiary amines such as trimethylamine salt, triethylamine salt, monoethanolamine salt, triethanolamine salt, pyridine salt; bases such as arginine or lysine. Salts with sex ammonium salts, etc.) or salts with inorganic bases (eg, inorganic acid salts such as hydrochlorides, sulfates, phosphates: ammonium salts; alkali metal salts such as sodium salts, potassium salts; calcium salts, magnesium salts, etc. Alkaline earth metal salts; or zinc salts, aluminum salts, etc.) and the like. Among them, preferred organic acid salts are triethanolamine salt, monoammonium salt, sodium salt, potassium salt, dipotassium salt, magnesium salt, or zinc salt, and particularly preferable organic acid salts are sodium salt, dipotassium salt, or magnesium salt. Is.

In the present invention, preferred organic acid salts are sodium ascorbate, tranexamate salt, calcium tranexamate, sodium salicylate, calcium salicylate, magnesium salicylate, potassium salicylate, sodium lactate, sodium tartrate, sodium citrate, disodium citrate, Trisodium citrate, potassium citrate, sodium succinate, disodium succinate, sodium oxalate, calcium gluconate, zinc gluconate, sodium pyrrolidone carboxylate, zinc pyrrolidone carboxylate, sodium glutamate, dipotassium glycyrrhizinate, mono glycyrrhizinate Examples include ammonium, sodium citrate, sodium glycolate, ammonium glycolate and the like. Among them, sodium ascorbate, tranexamate salt, calcium tranexamate, sodium salicylate, sodium lactate, sodium tartrate, sodium citrate, disodium citrate, trisodium citrate, sodium succinate, disodium succinate, calcium gluconate, Group consisting of zinc gluconate, zinc pyrrolidone carboxylate, sodium pyrrolidone carboxylate, sodium glutamate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, sodium phytate, sodium glycolate, ammonium glycolate, and sodium succinate and disodium succinate. One or more selected from the above is preferable, sodium ascorbate, sodium salicylate, sodium lactate, sodium citrate, disodium citrate, trisodium citrate, zinc gluconate, sodium pyrrolidone carboxylate, sodium glutamate, succinic acid. One or more selected from the group consisting of sodium and disodium succinate is more preferable, and one selected from the group consisting of sodium ascorbate, sodium lactate, sodium citrate, sodium citrate, and disodium succinate 1 Species or two or more are even more preferred.

In the present invention, the "derivative of an organic acid" refers to such a derivative of an organic acid, having a molecular weight of 1000 or less, preferably 800 or less, more preferably 600 or less, still more preferably 500 or less, and particularly preferably 450. The following, most preferably 350 or less organic compound acid derivatives. The organic acid derivative is preferably a water-soluble organic acid derivative.

In the present invention, as the derivative of the organic acid, ascorbyl palmitate such as sodium ascorbyl phosphate and magnesium ascorbyl phosphate; ascorbyl sulfate ester such as disodium ascorbyl sulfate; 2-O-ethyl Alkyl ascorbic acid such as ascorbic acid and 3-O-ethylascorbic acid; ascorbic acid glycoside such as ascorbic acid-2-glucoside; disostearyl ascorbyl phosphate disodium, ascorbyl palmitate trisodium; glyceryl ascorbic acid, Bisglyceryl ascorbic acid, alkylglyceryl ascorbic acid; (ascorbyl / tocopheryl) phosphate, (ascorbyl / tocopheryl) potassium phosphate, ascorbyl tocopheryl maleate; oil-soluble ascorbyl such as tetrahexyl decanoate ascorbyl, dipalmitate L-ascorbyl Derivatives; dimer of tranexamic acid; amide form of tranexamic acid such as methylamide hydrochloride; hydroquinone ester of tranexamic acid; vitamin ester such as vitamin A ester, vitamin E ester, vitamin C ester, tranexamic acid vitamin such as alkyl ester Estel; Genticinic acid ester of tranexamic acid; Cetyl hydrochloride salt of tranexamic acid; Polyhydric alcohol ester of ethylene glycol salicylate, dipropylene glycol salicylate, etc .; Alkyl salicylate such as methyl salicylate, 2-ethylhexyl salicylate; 4-methoxysalicylic acid, 4-methoxy Ascorbyl salicylic acid such as potassium salicylate or a salt thereof; one or more selected from the group consisting of acyl amino acids such as sodium stearoyl glutamate, sodium lauroyl glutamate, sodium lysine dilauroyl glutamate or a salt thereof: and stearyl glycyrrhetinate. included. Among them, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, disodium ascorbic acid sulfate, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid-2-glucoside, isostearyl ascorbic acid 2 sodium, ascorbic acid palmitate disophosphate, glyceryl ascorbic acid, bisglyceryl ascorbic acid, hexyl 3-glyceryl ascorbic acid, 3-glyceryl ascorbic acid, myristyl 3-glyceryl ascorbic acid, 3-lauryl glyceryl ascorbic acid, (ascorbic / Tocopheryl) Phosphate, (ascorbic / tocopheryl) potassium phosphate, ascorbic acid maleate tocopheryl, tranexamic acid methylamide hydrochloride, cetyl tranexamic acid hydrochloride, ethylene glycol salicylate, methyl salicylate, 2-ethylhexyl salicylate, 4-methoxysalicylic acid, 4 -One or more selected from the group consisting of potassium methoxysalicylate, sodium stearoyl glutamate, sodium lauroyl glutamate, sodium lysine dilauroyl glutamate, and stearyl glycyrrhetinate is preferable, and ascorbic acid phosphate sodium and ascorbic acid phosphate ester are preferable. Magnesium, ascorbic acid sulfate disodium, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid-2-glucoside, isostearyl ascorbic acid disodium disodium, palmitate ascorbic acid disodium trisodium, glyceryl ascorbic acid Acid, bisglyceryl ascorbic acid, hexyl 3-glyceryl ascorbic acid, 3-glyceryl ascorbic acid, myristyl 3-glyceryl ascorbic acid, 3-lauryl glyceryl ascorbic acid, 4-methoxysalicylic acid, 4-methoxysalicylic acid, potassium stearoyl glutamate, lauroyl One or more selected from the group consisting of sodium glutamate and sodium dilauroyl glutamate is more preferable, ascorbic acid phosphate sodium, ascorbic acid phosphate magnesium, ascorbic acid sulfate disodium, 2-O-. Ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid-2-glucoside, glyceryl ascorbic acid, bisglyce One or more selected from the group consisting of lyl ascorbic acid, hexyl 3-glyceryl ascorbic acid, 3-glyceryl ascorbic acid, 4-methoxysalicylate potassium, sodium stearoyl glutamate, and sodium dilauroyl glutamate lysine is more preferable, ascorbic acid. 1 selected from the group consisting of sodium acid phosphate, magnesium ascorbic acid phosphate, ascorbic acid sulfate disodium, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, and ascorbic acid-2-glucoside 1 Species or two or more are even more preferred.

These can be synthesized, or commercially available products can be used as they are.

These organic acids, organic acid salts, or derivatives of organic acids can also be used alone or in combination of two or more.

Here, in particular, when the component (B) is a paraoxybenzoic acid ester, the component (C-1) contains ascorbic acid, ascorbic acid salt, alkyl ascorbic acid, ascorbic acid phosphate, and ascorbic acid glycoside. In some cases, ascorbic acid, sodium ascorbic acid, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, ascorbic acid sulfate disodium, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid -2-glucoside, isostearyl ascorbic acid disodium, palmitate ascorbic acid trisodium, glyceryl ascorbic acid, bisglyceryl ascorbic acid, hexyl 3-glyceryl ascorbic acid, 3-glyceryl ascorbic acid, myristyl 3-glyceryl ascorbic acid, 3-Lauryl glyceryl Ascorbic acid, (ascorbic / tocopheryl) phosphate, (ascorbic / tocopheryl) potassium phosphate, and ascorbic tocopheryl maleate can be combined to combine two or more different ingredients selected from the group. It is also preferable from the viewpoint of antioxidative effect, ascorbic acid phosphate sodium, ascorbic acid phosphate magnesium, ascorbic acid sulfate disodium, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid- It is more preferable to combine two or more different components selected from the group consisting of 2-glucoside.

As the component (C-1) of the present invention, ascorbic acid, tranexamic acid, citric acid, salicylic acid, lactic acid, acetic acid, tartaric acid, malic acid, succinic acid, oxalic acid, gluconic acid, fumaric acid, propionic acid, aspartic acid, pyrrolidone. Carboxic acid, ε-aminocaproic acid, glutamate, aminoethylsulfonic acid, ellagic acid, kodiic acid, glycyrrhizinic acid, glycyrrhetinic acid, phytic acid, ferulic acid, glycolic acid, azelaic acid, ascorbic acid phosphate, ascorbic acid sulfate, Alkyl ascorbic acid, ascorbic acid glycoside, isostearyl ascorbic acid disodium, palmitate ascorbic acid disodium, glyceryl ascorbic acid derivative, tranexamic acid dimer, tranexamic acid amide, tranexamic acid ester, tranexamic acid One or more selected from the group consisting of alkyl, salicylic acid polyhydric alcohol ester, alkyl salicylate, alcocil salicylic acid, acylamino acid, glycyrrhetinic acid ester, and salts thereof is preferable, ascorbic acid, tranexamic acid, citric acid, Salicylic acid, lactic acid, tartrate acid, malic acid, succinic acid, gluconic acid, pyrrolidone carboxylic acid, ε-aminocaproic acid, glutamic acid, kodi acid, glycyrrhetinic acid, phytic acid, ferulic acid, glycolic acid, azelaic acid, sodium ascorbic acid, tranexamic acid Hydrophosphate, calcium tranexamate, sodium salicylate, sodium lactate, sodium tartrate, sodium citrate, disodium citrate, trisodium citrate, sodium succinate, disodium succinate, calcium gluconate, zinc gluconate, pyrrolidone carboxylic acid Sodium, zinc pyrrolidone carboxylate, sodium glutamate, sodium phytate, sodium glycolate, ammonium glycolate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, sodium ascorbic acid ester, magnesium ascorbic acid phosphate, ascorbic acid sulfate 2 Sodium, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid-2-glucoside, isostearyl ascorbic acid disodium, palmitate ascorbic acid disodium, glyceryl ascorbic acid, bisglyceryl ascorbic acid, Hexil 3-glyceryl ascor Vinic acid, 3-glyceryl ascorbic acid, myristyl 3-glyceryl ascorbic acid, 3-lauryl glyceryl ascorbic acid, potassium (ascorbyl / tocopheryl) phosphate, and ascorbyl tocopheryl maleate, methylamide tranexamic acid hydrochloride, cetyl tranexamicate hydrochloride , Ethylene glycol salicylate, methyl salicylate, 2-ethylhexyl salicylate, 4-methoxysalicylic acid, potassium 4-methoxysalicylate, sodium stearoyl glutamate, sodium lauroyl glutamate, sodium lysine dilauroyl glutamate, and stearyl glycyrrhetinate. Or two or more are more preferable, ascorbic acid, tranexamic acid, citrate, salicylic acid, lactic acid, gluconic acid, kodi acid, tartaric acid, phytic acid, glycolic acid, sodium ascorbate, sodium salicylate, sodium citrate, sodium citrate, citrate. Disodium acid, trisodium citrate, sodium succinate, disodium succinate, sodium pyrrolidone carboxylate, sodium glutamate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, sodium ascorbic acid phosphate, magnesium ascorbate phosphate, 2 One or more selected from the group consisting of -O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid-2-glucoside, sodium stearoyl glutamate, sodium lauroyl glutamate, sodium dilauroyl glutamate is more preferable. , Citrate, lactic acid, tranexamic acid, salicylic acid, gluconic acid, phytic acid, tartrate acid, sodium citrate, sodium citrate, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, 2-O-ethylascorbic acid, 3- O-Ethyl ascorbic acid, ascorbic acid-2-glucoside, sodium succinate, disodium succinate, are even more preferred, tranexamic acid, citrate, lactic acid, salicylic acid, gluconic acid, phytic acid, tartrate acid, disodium succinate, One or more selected from the group consisting of sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, and ascorbic acid-2-glucoside. The top is particularly preferred.

In the external composition for skin of the present invention, the total content of the organic acid, the organic acid salt, or the derivative of the organic acid with respect to the total amount of the composition is preferably 0.001 to 10% by mass, more preferably 0.005 to 7. It is by mass, more preferably 0.01 to 5% by mass, even more preferably 0.05 to 5% by mass, and particularly preferably 0.1 to 3% by mass.

In the external composition for skin of the present invention, the ratio of the total content of the organic acid, the organic acid salt, or the derivative of the organic acid to the component (A) is not particularly limited, but is based on 1 part by mass of the component (A). The organic acid, organic acid salt, or derivative of the organic acid is preferably 0.001 to 3.5 parts by mass, more preferably 0.01 to 2 parts by mass, and further preferably 0.05 to 1 part by mass.

In the external composition for skin of the present invention, the total content of ascorbic acid, salts thereof, or derivatives thereof is not particularly limited, but is preferably 0.001 to 10% by mass, more preferably 0.01 to 7% by mass. %, More preferably 0.05 to 5% by mass, even more preferably 0.1 to 5% by mass, and particularly preferably 0.5 to 3% by mass.
In the external composition for skin of the present invention, the total content of tranexamic acid, salts thereof, or derivatives thereof is not particularly limited, but is preferably 0.1 to 5% by mass, more preferably 0.5 to 5% by mass. %, More preferably 1-3% by mass.

((C-2) amphipathic compound)
The amphipathic component contained in the external composition for skin as the component (C-2) of the present invention has both a hydrophilic group and a hydrophobic group (parent oil group) in one molecule, resulting in an aqueous phase and an oil. Refers to all compounds that have an affinity for any of the phases (organic phases).

Such amphipathic compounds are not particularly limited, and examples thereof include alkylene oxide derivatives, phosphorylcholine-containing polymers, divalent carboxylic acid esters, and alkanediols having 5 to 10 carbon atoms. As the component (C-2) of the present invention, any one of these compounds alone or a combination of two or more thereof can be used. By blending the component (C-2) together with the components (A) and (B), a composition for external use on the skin in which precipitation is suppressed even when a high concentration of nicotinamide is blended is provided. It becomes possible.

The component (C-2) is preferably an alkylene oxide derivative represented by the following general formula (I), a 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, and a (eicosanedioic acid / tetradecanedioic acid) decaglyceryl. , Cyclohexanedicarboxylic acid bisethoxydiglycol, diethylhexyl succinate, diethoxyethyl succinate, and one or more selected from the group consisting of alkanediols having 5 to 10 carbon atoms.

（式中、
Ｚは、水素原子、又は、炭素数１〜３０のヒドロキシ化合物からｎ個のヒドロキシ基を除去することによって得られる残基を意味し；
ＡＯは、３〜４個の炭素原子を有するオキシアルキレン基を意味し；
ＥＯは、オキシエチレン基を意味し；
ＢＯは、４個の炭素原子を有するオキシアルキレン基を意味し；
ｎは、１〜９を意味し；
ａ，ｂ及びｃは、それぞれＡＯ、ＥＯ、ＢＯの平均付加モル数を意味し、独立して０〜２００である。但し、ａ、ｂ及びｃが全て０になることはない。また、ｎが２以上の時、複数のａ、ｂ及びｃはそれぞれ同一でも異なってもよい。Ｚが水素原子の時はｎは１である。
なお、ＡＯ及びＥＯは、ランダムに又はブロックの形態で付加されていてよい。）

(During the ceremony
Z means a residue obtained by removing n hydroxy groups from a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms;
AO means an oxyalkylene group having 3-4 carbon atoms;
EO means oxyethylene group;
BO means an oxyalkylene group having 4 carbon atoms;
n means 1-9;
a, b and c mean the average number of moles added of AO, EO and BO, respectively, and are 0 to 200 independently. However, a, b and c are not all 0. Further, when n is 2 or more, the plurality of a, b and c may be the same or different. When Z is a hydrogen atom, n is 1.
AO and EO may be added randomly or in the form of blocks. )

From the viewpoint of providing a good external composition for skin, the alkylene oxide derivative is preferably a compound represented by the following general formula (II).

（式中、
Ｚは、水素原子、又は、炭素数１〜３０のヒドロキシ化合物からｎ個のヒドロキシ基を除去することによって得られる残基を意味し；
ＡＯは、３〜４個の炭素原子を有するオキシアルキレン基を意味し；
ＥＯは、オキシエチレン基を意味し；
ｎは、１〜９を意味し；
ａ及びｂは、それぞれＡＯ、ＥＯの平均付加モル数を意味し、独立して０〜２００である。但し、ａ及びｂが全て０になることはない。また、ｎが２以上の時、複数のａ、ｂはそれぞれ同一でも異なってもよい。Ｚが水素原子の時はｎは１である。
なお、ＡＯ及びＥＯは、ランダムに又はブロックの形態で付加されていてよい。）

(During the ceremony
Z means a residue obtained by removing n hydroxy groups from a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms;
AO means an oxyalkylene group having 3-4 carbon atoms;
EO means oxyethylene group;
n means 1-9;
a and b mean the average number of moles added of AO and EO, respectively, and are independently 0 to 200. However, a and b are not all 0. Further, when n is 2 or more, the plurality of a and b may be the same or different. When Z is a hydrogen atom, n is 1.
AO and EO may be added randomly or in the form of blocks. )

The alkylene oxide derivative used in the present invention is a polymer of a specific alkylene glycol (when Z is a hydrogen atom) or a specific hydroxy compound (corresponding to Z) and a specific alkylene oxide group (general formula (I)). And (II) a compound obtained by adding (corresponding to the portion excluding Z) (when Z is a group obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms).

In the alkylene oxide derivative used in the present invention, from the viewpoint of providing a composition for external use on the skin in which precipitation is suppressed, AO is an oxyalkylene group having 3 to 4 carbon atoms, and examples thereof include an oxypropylene group and an oxybutylene group. (Oxyn-butylene group, oxyisobutylene group, oxyt-butylene group), oxytrimethylene group, oxytetramethylene group and the like can be mentioned. The AO is preferably an oxypropylene group, an oxybutylene group, and more preferably an oxypropylene group.

In the alkylene oxide derivative used in the present invention, BO is an oxyalkylene group having 4 carbon atoms, and examples thereof include an oxybutylene group (oxyn-butylene group, oxyisobutylene group, oxyt-butylene group) and oxytetramethylene. Group etc. can be mentioned. It is preferably an oxybutylene group.

In the alkylene oxide derivative used in the present invention, a, b, and c are independently 0 to 200, respectively. Each of a, b, and c is independently, preferably 1 to 200, more preferably 2 to 150, still more preferably 2 to 100, and particularly preferably 2 to 70.

In the chemical formula (I), a + b + c, which is the total number of each monomer unit of AO, EO, and BO, is preferably 3 or more, more preferably 5 or more, and further preferably 10 or more from the viewpoint of significantly exerting the effect of the present invention. Is. Further, a + b + c is preferably 450 or less, more preferably 350 or less, still more preferably 300 or less, and particularly preferably 250 or less, from the viewpoint of remarkably exerting the effect of the present invention.

In the chemical formula (II), a + b, which is the total number of each monomer unit of AO and EO, is preferably 3 or more, more preferably 5 or more, still more preferably 10 or more from the viewpoint of significantly exerting the effect of the present invention. .. Further, a + b is preferably 400 or less, more preferably 300 or less, still more preferably 250 or less, and particularly preferably 200 or less, from the viewpoint of remarkably exerting the effect of the present invention.

In the formulas (I) and (II), from the viewpoint of providing a composition for external use on the skin in which precipitation is suppressed, Z is a hydrogen atom or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, or tri. Obtained by removing n hydroxy groups from methylolpropane, erythritol, pentaerythritol, alkyl glucosides with 1 to 24 carbon atoms, diglycerin, xylitol, dipentaerythritol, sorbitol, inositol, sucrose, trehalose, or martitol. It is preferably a residue to be added, that is, a residue derived from these alcohol compounds, which is a hydrogen atom or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin (hydroxyl to which an alkylene oxide group can be added). (3 groups), pentaerythritol (4 hydroxy groups to which an alkylene oxide group can be added), alkyl glucoside having 1 to 24 carbon atoms (4 hydroxy groups to which an alkylene oxide group can be added), diglycerin (alkylene) More preferably, it is a residue obtained by removing n hydroxy groups from sorbitol (6 hydroxy groups to which an alkylene oxide group can be added) or sorbitol (6 hydroxy groups to which an alkylene oxide group can be added). It is a hydrogen atom or is a residue obtained by removing n hydroxy groups from an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, an alkyl glucoside having 1 to 24 carbon atoms, diglycerin, or sorbitol. It is more preferably a hydrogen atom, or it is obtained by removing n hydroxy groups from an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, an alkyl glucoside having 1 to 5 carbon atoms, or diglycerin. It is more preferably a residue, and even more preferably a residue obtained by removing n hydroxy groups from an alkyl monoalcohol, glycerin, or diglycerin having 4 to 24 carbon atoms.

In the chemical formula (I) or (II), when Z is an alkyl monoalcohol having 4 to 24 carbon atoms, butyl alcohol, tetradecyltetraalcohol, cetanol, and stearyl alcohol are preferable from the viewpoint of remarkably exerting the effect of the present invention. , Butyl alcohol, tetradecyltetra alcohol is particularly preferable.

In the chemical formula (I) or (II), when Z is an alkyl glucoside, an alkyl glucoside having 1 to 24 carbon atoms is preferable, and an alkyl glucoside having 1 to 16 carbon atoms is preferable from the viewpoint of remarkably exerting the effect of the present invention. More preferably, an alkyl glucoside having 1 to 10 carbon atoms is even more preferable, and an alkyl glucoside having 1 to 5 carbon atoms is particularly preferable.

Such an alkylene oxide derivative can be synthesized by a known method. For example, it is obtained by addition-polymerizing ethylene oxide and an alkylene oxide having 3 to 4 carbon atoms to a hydroxy compound having 1 to 30 carbon atoms, and then reacting the alkylene oxide with 4 carbon atoms. At the stage of addition polymerization of ethylene oxide and alkylene oxide having 3 to 4 carbon atoms to a hydroxy compound having 1 to 30 carbon atoms, ethylene oxide and alkylene oxide may be randomly polymerized or block polymerized. May be good. An alkali catalyst, a phase transfer catalyst, a Lewis acid catalyst, or the like can be used for the addition reaction. Generally, it is preferable to use an alkaline catalyst such as potassium hydroxide.

The molecular weight of such an alkylene oxide derivative is not limited as long as the effect of the present invention is exhibited, but is preferably 200 or more, more preferably 300 or more, from the viewpoint of significantly exerting the effect of the present invention. More preferably, it is 400 or more.

The properties of the alkylene oxide derivative are not limited as long as the effects of the present invention are exhibited, but in the above formulas (I) and (II), from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably in a semi-solid state at 25 ° C. It is preferable that the component is in the form of (including paste) to liquid.

In addition, such alkylene oxide derivatives include, for example, polyoxyalkylene glyceryl ether, polyoxyalkylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene oxybutylene alkyl ether, and the like. Polyoxyalkylene sorbit, polyoxyalkylene erythritol ether, polyoxyalkylene pentaerythritol ether, polyoxyalkylene diglyceryl ether, polyoxyalkylene trimethylol propane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyalkylene xylitol, Examples thereof include polyoxyalkylene dipentaerythritol, polyoxyalkylene inositol, polyoxyalkylene sucrose ether, polyoxyalkylene trehalose ether, and polyoxyalkylene multitoll ether.

Among them, the alkylene oxide derivatives are polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, and polyoxybutylene polyoxyethylene polyoxypropylene alkyl. Glucoside, polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbit, polyoxyethylene sorbit, polyoxy Ethylene polyoxypropylene sorbit, polyoxypropylene erythritol ether, polyoxyethylene erythritol ether, polyoxyethylene pentaerythritol ether, polyoxyethylene polyoxypropylene erythritol ether, polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene pentaerythritol ether , Polyoxybutylene polyoxyethylene pentaerythritol ether, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene diglyceryl ether, polyoxy Ethylene Trimethylol Propane, Polyoxypropylene Trimethylol Propane, Polyoxyethylene Polyoxypropylene Trimethylol Propane, Polyoxypropylene Glycol, Polyoxyethylene Polyoxypropylene Glycol, Polyoxybutylene Polyoxyethylene Polyoxypropylene Glycol, Polyoxyethylene Xylitol , Polyoxypropylene alkylenexylitol, polyoxyethylene polyoxypropylene xylitol, polyoxyethylene polyoxypropylene dipentaerythritol, polyoxyethylene dipentaerythritol, polyoxypropylene pentaerythritol, polyoxyethylene inositol, polyoxypropylene inositol, poly Oxyethylene polyoxypropylene inositol, polyoxyethylene sucrose ether, polio Xypropylene sucrose ether, polyoxyethylene polyoxypropylene sucrose ether, polyoxyethylene trehalose ether, polyoxypropylene trehalose ether, polyoxyethylene polyoxypropylene trehalose ether, polyoxyethylene multoll ether, polyoxypropylene multoll ether, and , Polyoxyethylene Polyoxypropylene Martinol ether, one or more selected from the group consisting of, preferably one or more.
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside , Polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbit, polyoxyethylene sorbit, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxypropylene pentaerythritol ether, poly Oxyethylene pentaerythritol ether, polyoxybutylene polyoxyethylene pentaerythritol ether, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene di One or more selected from the group consisting of glyceryl ether, polyoxyethylene polyoxypropylene trimethylolpropane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene glycol. Is more preferable
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxypropylene alkyl glucoside , Polyoxyethylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbit, polyoxyethylene polyoxypropylene sorbit, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, poly A group consisting of oxyethylene polyoxypropylene diglyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene diglyceryl ether, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene glycol. One or more selected from the above is more preferable.
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl ether , Polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbit, polyoxyethylene polyoxypropylene sorbit, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether. One or more selected types are even more preferable, and polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene methyl glucoside, and polyoxypropylene methyl. Glucoside, polyoxyethylene methyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene polyoxypropylene decyltetradecyl ether, polyoxypropylene sorbit, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxy One or more selected from the group consisting of propylene diglyceryl ether is even more preferable.

These alkylene oxide derivatives are Unilube 50MB-26 (polyoxyethylene polyoxypropylene butyl ether (17EO) (17PO)), Unilube 50MB-168 (polyoxyethylene polyoxypropylene butyl ether (37EO.)). ) (38PO)), Unilube 50MB-11 (Polyoxyethylene polyoxypropylene butyl ether (9EO) (10PO)), Unisafe 10P-8 (Polyoxyethylene polyoxypropylene cetyl ether (10E)) O.) (8P.O.)), Unilube MT-630B (Polyoxyethylene polyoxypropylene decyltetradecyl ether (30EO) (6P.O.)), Unilube MS-70K (Polyoxypropylene stearyl) Ether (15PO)), Uniol HS-1600D (polyoxyalkylene sorbit), Pronone # 208 (polyoxyethylene polyoxypropylene glycol (150EO) (35PO)), Pronon # 124P (poly) Oxyethylene (20) Polyoxypropylene (20) Glycol), Uniol D-2000 (Polypropylene Glycol), Macbiobride MG-10E (Polyoxyethylene Methyl Glucoside (10EO)), Macbiobride MG-20E ( Polyoxyethylene methyl glucoside (20EO)), Macbiobride MG-10P (polyoxypropylene methyl glucoside (10PO), Macbiobride MG-20P (polyoxypropylene methyl glucoside (20PO)) ), Wilbride MG2070 (polyoxybutylene polyoxyethylene polyoxypropylene methyl glucoside), Unilube 5TP-300KB (polyoxyethylene polyoxypropylene pentaerythritol ether (5EO) (65P.O.)); Unilube 50TG- 32 (Polyoxyethylene polyoxypropylene glyceryl ether (24EO) (24PO)), Wilbride S-753 (polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.O.) (8E. O.) (5PO)), Uniox G-1200 (polyoxyethylene glycerin (26EO)), Unilube DGP-700 (polyoxypropylene diglyceryl ether (9PO)), unil -V DGP-950 (Polyoxypropylene diglyceryl ether (14P. O. )) (Above, manufactured by NOF CORPORATION); SY-DP14 (polyoxypropylene diglyceryl ether (14PO)), SY-DP9 (polyoxypropylene diglyceryl ether (9PO)) (above, Sakamoto Yakuhin Kogyo Co., Ltd .; New Pole GP-1000 (PPG-16 glyceryl ether), New Pole SP-750 (polyoxyalkylene sorbitol ether), New Pole PE-68 (polyoxyethylene polyoxypropylene glycol (160E. O.) (30PO)), NOF PE-78 (polyoxyethylene polyoxypropylene glycol (150EO) (35PO)), NOF GEP-2800 (polyoxyethylene polyoxypropylene) Glyceryl ether (24EO) (24PO)) (all manufactured by Sanyo Kasei Co., Ltd.); Emargen PP-290 (polyoxyethylene polyoxypropylene glycol (160EO) (30PO), Kao Co., Ltd .; NIKKOL SG-G2424 (polyoxyethylene polyoxypropylene glyceryl ether (24EO) (24PO), NIKKOL SG-DTD630 (polyoxyethylene polyoxypropylene decyltetradecyl ether) (30E. O.) (6PO) (all manufactured by NOF CORPORATION); GLUCAM P-10 (polyoxypropylene methyl glucoside (10PO)), GLUCAM P-20 (polyoxypropylene methyl glucoside (20P.O.)). )) GLUCAM E-10 (polyoxyethylene methyl glucoside (10EO)), GLUCAM E-20 (polyoxyethylene methyl glucoside (20EO)) (all manufactured by Lubrizol), Braunon GL-26 (Polyoxyethylene glycerin (26EO)) (manufactured by Aoki Oil & Fat Industry Co., Ltd.) and the like are commercially available.
As commercially available products of alkylene oxide derivatives, from the viewpoint of remarkably exerting the effect of the present invention, Nieuport 50MB-26, Nieuport 50MB-168, Nieuport HS-1600D, Pronon # 208, Pronon # 124P, Uniol D-2000, Macbio Bride MG-10E, McBiobride MG-20E, McBiobride MG-10P, McBiobride MG-20P, Wilbride MG2070, Wilbride S-753, Nieuport 5TP-300KB, Nieuport 50TG-32, Nieuport G- 1200, Unilub DGP-700, Unilube DGP-950, SY-DP14, SY-DP9, Nieuport GP-1000, Nieuport SP-750, Nieuport PE-68, Nieuport PE-78, Nieuport GEP-2800, It is preferably one or more selected from the group consisting of NIKKOL SG-G2424, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, GLUCAM E-20, and Emargen PP-290, and Uniluport 50MB-26, Unilub 50MB-168, Unior HS-1600D, Pronon # 208, Pronon # 124P, McBiobride MG-10E, McBiobride MG-20E, McBiobride MG-10P, McBiobride MG-20P, Wilbride MG2070, Unilube 50TG-32, SY-DP14, SY-DP9, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, GLUCAM E-20 Nieuport PE-68, Nieuport PE-78, and Emargen PP-290 It is more preferable that it is one or more selected from the group consisting of Nieuport 50MB-26, Nieuport 50MB-168, McBiobride MG-10E, McBiobride MG-20E, McBiobride MG-10P, McBiobride. MG-20P, Pronon # 208, Pronon # 124P, Wilbride MG2070, Unilube 50TG-32, SY-DP14, SY-DP9, Nieuport PE-68, Nieuport PE-78, GLUCAM P-10, GLUCAM P-20 , GLUCAM E-10, GLUCAM E-20, and one or more selected from the group consisting of Emargen PP-290.

In the present invention, one type of alkylene oxide derivative may be used alone, or two or more types may be used in any combination.

Phosphorylcholine-containing polymer refers to all polymers containing an organic compound containing phosphorylcholine as a monomer. Although not particularly limited, a 2-metacloyloxyphosphorylcholine-containing polymer, which is a polymer obtained by polymerizing a monomer containing 2-methacryloyloxyethyl phosphorylcholine, is particularly preferable from the viewpoint of significantly exerting the effect of the present invention. Among them, one or more selected from the group consisting of 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer (polyquaternium-51) and polymethacryloyloxyethyl phosphorylcholine is preferable, and 2-methacryloyloxyethylphosphorylcholine / methacryl is preferable. A butyl acid copolymer is more preferred. Commercially available products of phosphorylcholine-containing polymers include Lipidure-PMB (2-methacryloyloxyethyl phosphorylcholine / butylmethacrylate copolymer solution, polyquaternium-51) and Lipidure-HM (polymethacryloyloxyethyl phosphorylcholine) (both NOF CORPORATION). ) Is preferred, and Lipidure-PMB (2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer solution) is more preferable.

The divalent carboxylic acid ester is an ester condensed with a divalent carboxylic acid and a hydroxy group such as glycol or glycol ether, and is not particularly limited. For example, (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 or cyclohexanedicarboxylic acid. Bisethoxydiglycolic acid, bis 1,4-cyclohexanedicarboxylic acid (triethylene glycol monoethyl ether), bis adipate (diethylene glycol monoethyl ether), bis adipate (triethylene glycol monoethyl ether), and diethoxy succinate Examples thereof include ethyl and diethylhexyl succinate, among which polyglyceryl-10 (eicosandioic acid / tetradecanedioic acid), bisethoxydiglycol cyclohexanedicarboxylic acid, diethoxyethyl succinate and diethylhexyl succinate are preferable, and eicosandioic acid / tetradecanedi. Acid) Polyglyceryl-10, bisethoxydiglycol cyclohexanedicarboxylic acid is more preferable, and bisethoxydiglycol cyclohexanedicarboxylic acid is even more preferable. The commercially available products are not particularly limited, but are: diethoxyethyl succinate (CRODAMOL DES), diethylhexyl succinate (CRODAMOL OSU) (all manufactured by Crowda Japan Co., Ltd.), Neosolue-Aqua, Neosolue-AquaS ((() Eikosandioic acid / tetradecanedioic acid) polyglyceryl-10) and Neosolue-Aquolio (bisethoxydiglycolcyclohexanedicarboxylic acid) (both manufactured by Nippon Seika Co., Ltd.) can be used.

The alkanediol has a carbon number of preferably 5 to 10, more preferably 5 to 8, and even more preferably 5 to 6 from the viewpoint of significantly exerting the effect of the present invention. For example, 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol are preferable, 1,2-pentanediol and 1,2-hexanediol are more preferable, and 1,2-pentanediol is further preferable. preferable. The commercially available products are not particularly limited, but are HYDROLLITE-5, HYDROLLITE-5 Green (manufactured by Symrise Co., Ltd.), KMO-6 (manufactured by Osaka Organic Chemical Industry Co., Ltd.), Microcare Emorient PTGJ, and Microcare Emorient HXD (THOR). Made) can be used.

In the present invention, as the component (C-2), in addition to the above-mentioned alkylene oxide derivative, 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, polymethacryloyloxyethylphosphorylcholine, (eicosanedioic acid / tetradecanedioic acid). Degacryceryl, bisethoxydiglycol cyclohexanedicarboxylic acid, diethylhexyl succinate, diethoxyethyl succinate, and alkanediol having 5 to 10 carbon atoms are preferable, and in addition to the above alkylene oxide derivatives, 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate Copolymers, (eicosanedioic acid / tetradecanedioic acid) degacryceryl, bisethoxydiglycol cyclohexanedicarboxylic acid, 1,2-pentanediol, 1,2-hexanediol, or 1,2-octanediol are more preferred, as described above. In addition to the alkylene oxide derivative of the above, 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, bisethoxydiglycol cyclohexanedicarboxylic acid, 1,2-pentanediol, and 1,2-hexanediol are even more preferable. As the above-mentioned component (C-2), one type may be used alone, or two or more types may be used in any combination.

In the external composition for skin of the present invention, the total content of the component (C-2) is not particularly limited and is appropriately set according to the type of the component (B), the type of other compounding components, and the like. From the viewpoint of significantly exerting the effect of the invention, it is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, still more preferably 0.01% by mass or more, and further, based on the total amount of the composition. More preferably, it is 0.05% by mass or more, and most preferably 0.1% by mass or more.
The total content of the component (C-2) is preferably 20% by mass or less, more preferably 15% by mass or less, still more preferably 12% by mass or less, still more preferably, based on the total amount of the composition. It is 10% by mass or less, most preferably 8% by mass or less.
The total content of the component (C-2) is preferably 0.001 to 20% by mass, more preferably 0.005 to 15% by mass, still more preferably 0.01 to 12% by mass, based on the total amount of the composition. %, More preferably 0.05 to 10% by mass, and most preferably 0.1 to 8% by mass.

In the external composition for skin of the present invention, the ratio of the total content of the component (C-2) to the component (B) is not particularly limited, but the component (C-2) is contained in 1 part by mass of the component (B). It is preferably 0.01 to 50,000 parts by mass, more preferably 0.05 to 10,000 parts by mass, and further preferably 0.1 to 5,000 parts by mass.

In the external composition for skin of the present invention, the content of the alkylene oxide derivative alone with respect to the total amount of the composition is not particularly limited as long as the effects of the present invention are exhibited.
The content of the alkylene oxide derivative alone is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, still more preferably 0.5% by mass or more, based on the total amount of the composition. ..
The content of the alkylene oxide derivative alone is preferably 15% by mass or less, more preferably 10% by mass or less, still more preferably 8% by mass or less, based on the total amount of the composition.
The content of the alkylene oxide derivative alone is preferably 0.01 to 15% by mass, more preferably 0.1 to 10% by mass, and further preferably 0.% by mass, based on the total amount of the composition. It is 5 to 8% by mass, and even more preferably 0.5 to 5% by mass.

In the external composition for skin of the present invention, the content of decaglyceryl (eicosanedioic acid / tetradecanedioic acid) alone with respect to the total amount of the composition is not particularly limited as long as the effect of the present invention is exhibited.
The single content of (icosanedioic acid / tetradecanedioic acid) decaglyceryl is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, still more preferably 0.005% by mass or more, based on the total amount of the composition. It is 0.01% by mass or more, and more preferably 0.05% by mass or more.
The single content of (icosanedioic acid / tetradecanedioic acid) decaglyceryl is preferably 15% by mass or less, more preferably 10% by mass or less, still more preferably 8% by mass or less, based on the total amount of the composition. , Even more preferably 5% by mass.
The single content of (icosanedioic acid / tetradecanedioic acid) decaglyceryl is preferably 0.001 to 15% by mass, more preferably 0.005 to 10% by mass, still more preferably, based on the total amount of the composition. Is 0.01 to 8% by mass, and even more preferably 0.05% to 5% by mass.

In the external composition for skin of the present invention, the content of bisethoxydiglycolcyclohexanedicarboxylic acid alone with respect to the total amount of the composition is not particularly limited as long as the effects of the present invention are exhibited.
The content of bisethoxydiglycol cyclohexanedicarboxylic acid alone is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, still more preferably 0.01% by mass, based on the total amount of the composition. % Or more, and even more preferably 0.05% by mass or more.

The content of bisethoxydiglycol cyclohexanedicarboxylic acid alone is preferably 15% by mass or less, more preferably 10% by mass or less, still more preferably 8% by mass or less, still more preferably, based on the total amount of the composition. Is 5% by mass.
The content of bisethoxydiglycol cyclohexanedicarboxylic acid alone is preferably 0.001 to 15% by mass, more preferably 0.005 to 10% by mass, still more preferably 0.% by mass, based on the total amount of the composition. It is 01 to 8% by mass, and even more preferably 0.05% to 5% by mass. The content of bisethoxydiglycol cyclohexanedicarboxylic acid alone is preferably 10% by mass or less, more preferably 8% by mass or less, still more preferably 5% by mass or less, based on the total amount of the composition.

The content of bisethoxydiglycol cyclohexanedicarboxylic acid alone is preferably 0.001 to 10% by mass, more preferably 0.005 to 8% by mass, still more preferably 0.% by mass, based on the total amount of the composition. It is 01 to 5% by mass, and even more preferably 0.05 to 3% by mass.

In the external composition for skin of the present invention, the content of the 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer alone with respect to the total amount of the composition is not particularly limited as long as the effects of the present invention are exhibited.
The single content of the 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, still more preferably, based on the total amount of the composition. Is 0.005% by mass or more, and even more preferably 0.01% by mass or more.
The content of the 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer alone is preferably 2% by mass or less, more preferably 1% by mass or less, still more preferably 0.% by mass, based on the total amount of the composition. It is 5% by mass or less, and more preferably 0.2% by mass or less.
The content of the 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer alone is preferably 0.0001 to 2% by mass, more preferably 0.001 to 1% by mass, based on the total amount of the composition. It is even more preferably 0.005 to 0.5% by mass, and even more preferably 0.01% to 0.2% by mass.

In the external composition for skin of the present invention, the content of alkanediol having 5 to 10 carbon atoms alone with respect to the total amount of the composition is not particularly limited as long as the effects of the present invention are exhibited.
The single content of the alkanediol having 5 to 10 carbon atoms is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, still more preferably 0.01, based on the total amount of the composition. By mass or more, even more preferably 0.1% by mass or more.
The single content of the alkanediol having 5 to 10 carbon atoms is preferably 10% by mass or less, more preferably 7% by mass or less, still more preferably 5% by mass or less, still more, based on the total amount of the composition. Preferably, it is 3% by mass or less.
The single content of the alkanediol having 5 to 10 carbon atoms is preferably 0.0001 to 10% by mass, more preferably 0.001 to 7% by mass, still more preferably 0, based on the total amount of the composition. It is 0.01 to 5% by mass, and even more preferably 0.1 to 3% by mass.

In the external composition for skin of the present invention, as the component (C), any one or more of the components (C-1) and any one or more of the components (C-2) may be contained in combination. preferable.

In the external composition for skin of the present invention, as the component (C), any one or more of the components (C-1) and any one or more of the components (C-2) may be contained in combination. preferable.

Such combinations include ascorbic acid, tranexamic acid, citrate, salicylic acid, lactic acid, gluconic acid, succinic acid, tartaric acid, succinic acid, phytic acid, glycolic acid, sodium ascorbate, and sodium salicylate as components of (C-1). , Sodium lactate, sodium citrate, disodium citrate, trisodium citrate, sodium succinate, disodium succinate, sodium pyrrolidone carboxylate, sodium glutamate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, sodium ascorbate phosphate , Ascorbic acid phosphate magnesium, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid-2-glucoside, sodium stearoyl glutamate, sodium lauroyl glutamate, and sodium dilauroyl glutamate (C-2) Ingredients: polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, poly Oxyethylene methyl glucoside, polyoxypropylene methyl glucoside, polyoxypropylene diglyceryl ether, polyoxyethylene diglyceryl ether, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene decyltetradecyl ether, polyoxyethylene polyoxypropylene butyl ether, 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer solution, polymethacryloyloxyethylphosphorylcholine, polyglyceryl-10 (eicosandioic acid / tetradecanedioic acid), bisethoxydiglycolcyclohexanedicarboxylic acid, diethoxyethyl succinate, and succinic acid It is preferable to combine with one or more selected from the group consisting of diethylhexyl.
(C-1) Ingredients ascorbic acid, tranexamic acid, citric acid, lactic acid, salicylic acid, gluconic acid, phytic acid, tartaric acid, succinic acid, disodium succinate, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, and ascorbic acid-2-glucoside and (C-2) components, polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxy Propylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene methyl glucoside, polyoxypropylene methyl glucoside, polyoxyethylene polyoxypropylene decyltetradecyl ether , Polyoxyethylene polyoxypropylene butyl ether, 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer solution, (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10, cyclohexanedicarboxylic acid bisethoxydiglycol, succinate diethoxyethyl, And one or more selected from the group consisting of diethylhexyl succinate is more preferable.

In particular, when the component (C-2) is added to the external composition for skin of the present invention, it has a good feeling of use (penetration feeling, moisturizing property, etc.) while maintaining a sufficient antiseptic effect, and further, nicotinamide. It is possible to realize a preparation having both various effectiveness and good stability (precipitation).

[Other useful ingredients]
In addition to the components (A), (B), and (C), the external composition for skin of the present invention has an ultraviolet absorber, an ultraviolet protective agent, a whitening component, in order to add other useful actions. An anti-inflammatory component, an acidic mucopolysaccharide, or the like can be added. The respective components are not particularly limited as long as they can be used in the fields of pharmaceuticals, quasi-drugs, and cosmetics, and any one can be appropriately selected and used.

(UV absorber)
The UV absorber is not limited, but is preferably salicylic acid-based UV absorber, silicic acid-based UV absorber, benzoylmethane-based UV absorber, benzoic acid ester derivative UV absorber, triazine derivative UV absorber, and benzal. It may be a malonate derivative UV absorber, an octocrylene UV absorber, an imidazole sulfonic acid derivative UV absorber, a benzophenone derivative UV absorber, or the like.

In the present invention, such ultraviolet absorbers include, but are not limited to, 2-ethylhexyl paramethoxysilicate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2- [4- (diethylamino)-. 2-Hydroxybenzoyl] benzoic acid hexyl ester, 2-ethylhexyl dimethoxybenzidenedioxoimidazolidine propionate, 2,2'-methylenebis [6- (2H-benzotriazol-2yl) -4- (1,1,3) , 3-Tetramethylbutyl) phenol], 2,4-bis- [{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl] -6- (4-methoxyphenyl) -1,3,5- Triazine, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, dimethicodiethylbenzalmaronate, 2-cyano-3,3-diphenylpropa-2 -Preferably 2-ethylhexyl ester of enoic acid, 2-phenylbenzoimidazole-5-sulfonic acid, 2-ethylhexyl paramethoxysilicate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2- [4 -(Diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4-bis- [{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl] -6- (4-methoxyphenyl) -1 , 3,5-Triazine, 2,4,6-Tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, 2-phenylbenzoimidazole-5-sulfonic acid is more preferable. , 2-Ethylhexyl paramethoxysilicate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4-bis- [{4- (2-ethylhexyloxy) -2-hydroxy} -Phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine More preferable.

As the ultraviolet absorber, a commercially available product can be used, or a synthetic product can be used.

Commercially available products are not limited, but can be appropriately combined and used, such as Uvinul MC80 (manufactured by BASF) and Parsol 1789 (manufactured by DSM Nutrition Japan).

The total content of the UV absorber with respect to the total amount of the external composition for skin is preferably 1 to 20% by mass, more preferably 3 to 20% by mass, still more preferably 5 to 20% by mass, and particularly more preferably 6 to 20%. It is by mass, most preferably 7 to 15% by mass.

In the external composition for skin of the present invention, the ratio of the content of the ultraviolet absorber to the component (A) is not particularly limited, but is preferably 0.6 to 2 with respect to 1 part by mass of the total content of the component (A). It is by mass, more preferably 1 to 2 parts by mass, and even more preferably 1.4 to 2 parts by mass.

(UV protection agent)
Examples of the ultraviolet protective agent include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, silicic anhydride, cerium silicate, and hydrous silicic acid, and their components. Inorganic compounds coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica and talc, composited with resin powders such as polyamide, polyethylene, polyester, polystyrene and nylon, and silicone oil and aluminum fatty acid Examples thereof include those treated with salts, alkyl titanates and the like. Of these, inorganic compounds such as zinc oxide, titanium oxide, and iron oxide, and those obtained by coating these inorganic compounds with inorganic powder such as aluminum hydroxide, hydrous silicic acid, mica, and talc, or silicone oil are preferable. When the ultraviolet protective agent is blended, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, 0.001 to 35% by mass based on the total amount of the external composition for skin of the present invention. It is preferably 0.1 to 10% by mass.

Further, in the present invention, the ultraviolet absorber and the ultraviolet protective agent may be complexed, supported, or encapsulated in another component, and the combination thereof is not particularly limited.

(Whitening ingredient)
In addition to nicotinamide, a whitening ingredient can be added to the external composition for skin of the present invention. For example, placenta, arbutin, lucinol, chamomile ET, hydroquinone, tocopherol (α, β, δ, etc.), plant extracts (eg, iris root extract, almond oil, aloe vera extract, acerola extract, ages extract, augon extract, Otogirisou extract, Odorikosou extract, seaweed extract, cucumber extract, chamomile extract, shakuyaku extract, sohakuhi extract, soybean extract, cha extract, white tea extract, tokinsenka, hamamelis, yokunin, honeybee extract, hop extract, prune extract, kanzo extract, oil-soluble Kanzo extract, Shimotsukesou extract, Murasakikibu extract, Alpinia katsumadai seed extract, Grave fruit extract, Izayoi rose extract, Lemon extract, Kiwi extract, Pine extract, Neem leaf extract, Artichoke extract, Sugina extract, Oobaku extract, Mematsuyoigusa extract, Moonflower oil, Bilberry leaf Extracts, Himefuuro extract, Akkesiso extract, Seiyoshiroyanagi extract, Tsubokusa extract, Sanshuyu fruit extract, etc.) and the like. Among them, α-tocopherol, δ-tocopherol, β-tocopherol, iris root extract, aloe vera extract, acerola extract, agetsu extract, ginger extract, otogirisou extract, odorikosou extract, seaweed extract, cucumber extract, chamomile extract, shakuyaku extract, soybean extract, soybean extract, Cha extract, Shirocha extract, Tokinsenka extract, Hamamelis extract, Yokuinin, Hatomugi extract, Prune extract, Kanzo extract, Oil-soluble Kanzo extract, Alpinia cutlet seed extract, Grave fruit extract, Izayoi rose extract, Lemon extract, Kiwi extract, Artichoke extract , Sugina extract, Oobaku extract, Mematsuyoigusa extract, Evening primrose oil, Bilberry leaf extract, Himefuuro extract, Akkesiso extract, Seiyoshiroyanagi extract, Tsubokusa extract, and Sanshuyu fruit extract are preferably one or more.

When the whitening ingredient described above is added to the external composition for skin of the present invention in addition to nicotinamide, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for external use on the skin. With respect to the total amount of the composition, for example, the content when using other than the plant extract is, for example, 0.01 to 5% by mass. When a plant extract is used, the content is, for example, 0.00001 to 20% by mass, preferably 0.001 to 10% by mass, based on the total amount of the external composition for skin in terms of an extract such as an extract. ..

(Anti-inflammatory component)
Anti-inflammatory components include, for example, components derived from plants (eg, components derived from comfrey, azulene, dokudami), calamine, allantoin, zinc oxide, pyridoxin hydrochloride, tocopherol acetate, menthol, camphor, terepine oil, etc. Examples thereof include ufenamate, bufexamac, ibuprofen piconol, azulene and derivatives thereof (for example, guaiazulene, azulene, etc.), steroids and the like. When the anti-inflammatory component is blended, it is, for example, 0.0003 to 10% by mass, preferably 0.001 to 5% by mass, based on the total amount of the external composition for skin of the present invention.

(Acid mucopolysaccharide)
Acidic mucopolysaccharides include hyaluronic acid, heparinoids and the like.

Hyaluronic acid obtained by extracting from animal tissues, microorganisms, etc. is generally said to have an average molecular weight of about 1 million or more, and is known to be extremely high molecular weight. In the present invention, such high molecular weight hyaluronic acid may be used, or low molecular weight hyaluronic acid and hyaluronic acid oligosaccharide (4 sugars, 6) obtained by a method such as decomposition of high molecular weight hyaluronic acid and fermentation by microorganisms. Sugars, octasaccharides, etc.) and unsaturated hyaluronic acid (having double bonds at the 4- and 5-positions of D-glucuronic acid) may be used.

Salts of hyaluronic acid or derivatives thereof are also not particularly limited as long as they are pharmacologically or physiologically acceptable, for example, alkali metals such as sodium and potassium, alkaline earth metals such as calcium and magnesium, aluminum and the like. Examples include salt with metal. Preferably, a sodium salt, a potassium salt, or a zinc salt is used as the salt of hyaluronic acid or a derivative thereof.

Heparinoid means a general term for polysulfated mucopolysaccharides such as chondroitin polysulfate, and an average of 0.5 to 5 molecules, preferably an average of 0.6 to 3 molecules of sulfate per monosaccharide constituting the mucopolysaccharide. It preferably has a group. More specifically, the heparinoid contains heparin, chondroitin sulfate D called chondroitin polysulfate, chondroitin sulfate E, and the like.

In the present invention, such acidic mucopolysaccharides include, but are not limited to, hyaluronic acid, low molecular weight hyaluronic acid, hyaluronic acid oligosaccharide (tetrasaccharide), acetylated hyaluronic acid, cationized hyaluronic acid, and hydrolyzed hyaluronic acid. Alkyl (C12-13) glyceryl, crosslinked hyaluronic acid, carboxymethyl hyaluronic acid, alkylene glycol hyaluronate, dimethylsilanol hyaluronate, heparin analogs and / or salts thereof are preferred, hyaluronic acid, low molecular weight hyaluronic acid, acetylated hyaluronic acid. Acids, hydroxypropyltrimonium hyaluronate, carboxymethyl hyaluronic acid, propylene glycol hyaluronate, sodium hyaluronate, zinc hyaluronate, low molecular weight zinc hyaluronate, acetylated sodium hyaluronate, sodium hyaluronate crosspolymer, and heparin analogs More preferred are sodium hyaluronate, zinc hyaluronate, low molecular weight zinc hyaluronate, acetylated hyaluronic acid, hydroxypropyltrimonium hyaluronate, propylene glycol hyaluronate, sodium crosspolymer hyaluronate, and heparin analogs.

The acidic mucopolysaccharide can be used by using a commercially available product or by synthesizing it.

Such acidic mucopolysaccharides
In the external composition for skin of the present invention, it is preferably 0.0001 to 1% by mass, more preferably 0.001 to 0.5% by mass, based on the total amount of the composition.

[Other ingredients]
The external composition for skin of the present invention may contain other components in addition to the components (A), (B), and (C) as long as the effects of the present invention are not impaired. Specific examples of other components include refreshing components, moisturizing components, antibacterial or bactericidal components, vitamins, amino acids or derivatives thereof, cell activating components, antiaging components, blood circulation promoting components, keratin softening components, astringent components, and the like. Examples thereof include anti-glycation components, peptides or derivatives thereof.

Examples of the refreshing ingredient include camphor, menthol (eg, l-menthol, dl-menthol, menthylglyceryl ether, menthyl lactate, menthyl 3-hydroxybutyrate, mentoxypropanediol, menthyl succinate, etc.), borneol, eugenol, etc. Sesquiterpenes such as cineole, timol, bisabolol, α-pinene, or monoterpenes such as limonene, diterpenes, eucalyptus oil, peppermint oil, butterfly oil, kehi oil, peppermint oil, mint oil, tea tree oil, chamomile oil, Examples thereof include essential oils such as rosemary oil, lemon oil, orange oil, thyme oil, sage oil, and clove oil.

Moisturizing ingredients include, for example, sodium hyaluronate, heparin analogs, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, and high molecular weight compounds such as chitosan or their hydrolyzates; amino acids such as glycine, arginine; urea. Natural moisturizing factors such as, and lipids such as ceramide and phospholipids; trimethylglycine (betaine); hydroxyethylurea; acrylate / acrylamide / dimethyldialylammonium chloride copolymer; and honeybee seed extract, yomogi leaf Examples include plant extracts such as extracts, chamomile extracts, hamamelis extracts, white birch sap, akeshisou extracts, lilac extracts, cha extracts, lavender-oils, and perilla extracts; animal extracts such as placenta extracts.

Examples of antibacterial or bactericidal components include chlorhexidine, benzalkonium chloride, acrinol, sulfur, resorcin, ethanol, benzethonium chloride, adaparene, benzoyl peroxide, clindamycin, cresol, gluconic acid and its derivatives, and popidone iodine. , Potassium iodide, iodine, triclocarvan, triclosan, photosensitizer 101, photosensitizer 201, phenoxyethanol, alkyldiaminoglycine hydrochloride, chlorhexidine gluconate, and zinc paraphenolsulfonate, picrotone olamine, myconazole, etc. Can be mentioned.

Examples of vitamins include vitamin As such as retinol derivatives (retinol, retinol acetate, retinol palmitate, etc.), tocopheryl retinoeto, etc .; vitamin Es such as tocopherol, tocopherol acetate; riboflavin and the like. Vitamin B2; nicotinic acids other than nicotinic acid amide; vitamin D; vitamin K, γ-orizanol, vitamin B1; vitamin B6 such as pyridoxin hydrochloride; vitamin B12; folic acid; pantothenic acid such as pantenol; Vitamins; as well as vitamin-like acting factors such as carnitine and pyroquinolinquinone.

Examples of amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamine, asparagine, aspartic acid, cysteine, cystine and methionine. , Leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosin, creatin and the like.

Examples of cell activating components include vitamins (retinol, thiamine, riboflavin, pyridoxin hydrochloride, pyrroloquinolinquinones pantothenate, etc.); tannin, flavonoid, saponin, allantin, placenta, proteoglycan, photosensitizer 301, plant extract ( For example, extracts of soybeans, bilberries, lemongrass, aloe vera, chlorella, barley, yokunin, chamomile, dokudami, hops, carrots); royal jelly, royal jelly extract; whey, yogurt extract, emulsion-derived extracts such as hydrolyzed milk protein , Yeast extract and the like. Examples of anti-aging ingredients include hydrolyzed soybean protein, retinoids (retinol, retinoic acid, retinal, etc.), astaxanthin, coenzyme Q10, pangamic acid, ursolic acid, turmeric extract, sphingosine derivative, silicon, silicic acid, N-methyl-. L-serine, mevalonolactone, peptides (caprooil tetrapeptide-3, oligopeptide-24, etc.), plant extracts (eg, artichoke, izayoi rose, seaweed, bilberry, white birch, broadleaf plantain, touki, ginger, otogirisou, comfrey , Neem, Novara, Broadleaf Plantain, Himefuuro, Bodaiju, Peptide, etc.). Among them, hydrolyzed soybean protein, retinol, retinol acetate, retinol palmitate, caprooil tetrapeptide-3, oligopeptide-24, artichoke leaf extract, seaweed extract, bilberry leaf extract as cell activating components and / or antiaging components. , Comfrey leaf extract, neem leaf exo, and Himefuuro extract are preferable.

Examples of blood circulation promoting components include plants (eg, ginseng, Ashitaba, Arnica, Ginkgo, Angelica acutiloba, Enmeisou, Dutch oak, Chamomile, Ro-makamitsure, Carrot, Gentiana, Gobo, Rice, Sanzashi, Shiitake, Seiyousanzashi, Seiyounezu. , Senkyu, Senburi, Thyme, Chouji, Chimpi, Angelica acutiloba, Tounin, Touhi, Carrot, Garlic, Butcher-Bloom, Grape, Button, Maronie, Melissa, Yuzu, Yokuinin, Rozumari-, Rosehip, Chimpi, Ingredients derived from Angelica acutiloba, Angelica acutiloba, peach, apricot, walnut, and corn); dl-α-tocopherol acetate, tocopherol nicotinate, glucosyl hesperidin, hesperidin, glucosyl hesperidin, and the like.

Examples of the keratin softening component include lanolin, urea, and sulfur.

Examples of the astringent component include zinc paraphenol sulfonate, zinc oxide, menthol, ethanol and the like.

Examples of anti-glycation components include Budreja axilaris leaf extract, seaweed fruit extract, edelweiss extract, ginkgo extract, cherry leaf extract, pomegranate extract, sardine extract, sardine extract, sardine extract, dokudami extract, bilberry leaf extract, etc. Green tea extract, tea extract, marronnier extract, roma chamomile extract, yomogi extract and other plant extracts, evening primrose oil, Amler fruit, fruit juice or their extracts, L-arginine, L-lysine, hydrolyzed casein, hydrolyzable tannin , Carnosin and the like.

Examples of the peptide or its derivative include keratin-degrading peptide, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, succinylated atelocollagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrate. Degraded collagen, elastin-degrading peptide, conchiolin-degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptide, hydrolysis Wheat protein, casein-degrading peptide, acylated peptide (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.) and the like can be mentioned.

Other components may be used alone or in combination of two or more. Further, the present invention is not limited to these, and known ingredients blended in external preparations for skin such as cosmetics and pharmaceuticals can be appropriately used.

[Base or carrier]
From the viewpoint of improving usability, stability, etc., the external composition for skin of the present invention is added to the above components (A), (B), and (C) as long as the effects of the present invention are not impaired. It may contain a base or a carrier. Examples of the base or carrier include, but are not limited to, polyethylene glycol; glycol ether; lower alcohols such as ethanol and isopropanol; oils; surfactants; thickeners, and the like, and cosmetics and pharmaceuticals. Known ingredients to be blended in external preparations for skin such as, etc. can be used.

In the external composition for skin of the present invention, an oil component that functions as a base or a carrier can also be used. Examples of such oils include hydrocarbon oils, ester oils, fats and oils, silicones, waxes and the like. Specifically, hydrocarbons such as liquid paraffin, liquid isoparaffin, squalane, vaseline, gelled hydrocarbon, α-olefin oligomer; dimethicone, crosslinked methylpolysiloxane, highly polymerized methylpolysiloxane, phenyl-modified silicone, cyclic silicone, Silicones such as polyether-modified silicones; higher alcohols; higher fatty acids; isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, diisopropyl adipate, decyl oleate, isodecyl oleate, dimethyl octane Hexyldecyl acid acid, diisopropyl sebacate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, diisopropyl adipate, isotorideyl isononanoate, cetyl lactate, isostearyl isostearate, 12-hydroxystearyl Cholesteryl acid, cholesteryl stearate, cholesteryl oleate, macadamia nut fatty acid phytosteryl, phytosteryl oleate, dextrin palmitate, inulin stearate, hydrogenated jojoba oil, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, neo dicaprate Pentyl glycol, tri2-ethylhexyl trimeritate, tritridecyl trimeritate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, glycerin tri-2-ethylhexanoate , Trimethylolpropane triisostearate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, oleyl oleate, di lauroyl glutamate (phytosteryl / octyldodecyl), lauroyl glutamate Di (octyldodecyl / phytosteryl / behenyl), triethyl citrate, dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, dipentaerythrityl tripolyhydroxystearate, tri (bechenic acid) / Isostearic acid / Eikosandioic acid) Esters such as glyceryl; waxes such as jojoba oil and miuro; avocado oil, macadamia nut oil, kukui nut oil , Hazelnut oil, corn oil, olive oil, saflower oil, coconut oil, cinnamon oil, jojoba oil, grape seed oil, sunflower oil, almond oil, shea butter, southern ka oil, rapeseed oil, sesame oil, cacao butter, palm oil, hardened Oils and fats such as palm oil, palm oil, palm kernel oil, mokuro kernel oil, mokuro, wheat germ oil, rice germ oil, rice bran oil, cotton seed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil, shea butter, etc. Can be given.

In the external composition for skin of the present invention, a surfactant that functions as a base or a carrier can also be used. Examples of such a base or carrier include sorbitan fatty acid esters such as sorbitan stearate, sorbitan sesquioleate, sorbitan oleate, sorbitan isostearate, sorbitan laurate, and sorbitan olive oil fatty acid; polyoxyethylene monolaurate (20). ) Polyoxyethylene such as sorbitan, polyoxyethylene monolaurate (80) sorbitan, polyoxyethylene monostearate (20) sorbitan, polyoxyethylene monooleate (20) sorbitan, polyoxyethylene isostearate (20) sorbitan, etc. Polysorbate fatty acid ester; glycerin fatty acid ester such as glycerin monooleate, glycerin monostearate, glycerin monomillistate; glycerin alkyl ether such as monoisostearyl glyceryl ether, monomyristyl glyceryl ether; diglyceryl monostearate, decaglyceryl decastea Polyglycerin fatty acid esters such as rate, decaglyceryl decaisostearate, diglyceryl diisostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; polyethylene glycol fatty acid esters such as polyethylene glycol monostearate; polyoxy Hardened castor oil derivatives such as ethylene-hardened castor oil 40, polyoxyethylene-hardened castor oil 50, polyoxyethylene-hardened castor oil 60, polyoxyethylene-hardened castor oil 80; polyoxyethylene glycerin such as polyoxyethylene monococonut oil fatty acid glyceryl Fatty acid ester; polyoxyethylene sterol / hydrogenated sterol such as polyoxyethylene phytosterol, polyoxyethylene phytostanol, polyoxyethylene cholestanol; sucrose fatty acid ester; ether carboxylate, alkyl phosphate ester salt, sodium cocoylglycine, etc. N-acylamino acid salt, acylated taurate; amines such as stearylamine and oleylamine; polyoxyethylene / methylpolysiloxane copolymer, laurylPEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, etc. Examples thereof include silicone-based surfactants or naturally-derived surfactants such as lecithin, hydrogenated lecithin, saponin, sodium surfactinate, cholesterol, and bile acid. Not limited.

Examples of the thickener include guar gum, locust bean gum, carrageenan, xanthan gum, sclerothium gum, xanthan gum, gellan gum, dextran, pectin, purulan, agar, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl methacrylate. Copolymers, (Hydroxyethyl Acrylate / Acryloyldimethyltaurine Na) Copolymers, (Na Acrylic Acid / Acryloyldimethyltaurine Na) Copolymers, Polyacrylic Acid Amid, Polyethylene Glycol, Arginic Acid, Sodium Arginate, Protinic Alginate Glycolester, Macrogol, Examples thereof include sodium chondroitin sulfate and cellulosic thickeners such as hydroxyethyl cellulose (hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, hydrophobicized hydroxypropyl methyl cellulose, carboxymethyl cellulose and the like).

The base or carrier can be used alone or in combination of two or more.

[Additive]
The external composition for skin of the present invention includes known additives added to pharmaceuticals, quasi-drugs, or cosmetics, for example, antioxidants, pH adjusters, and stabilizers, as long as the effects of the present invention are not impaired. Agents, colorants, fragrances, powders and / or pal luster imparting agents, irritation reducing agents and the like can be added.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sodium sulfite, tocopherol, tocopherol derivative, L-cysteine hydrochloride and the like.

Examples of the pH adjuster include inorganic acids and organic bases.

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like. Examples of the irritation reducing agent include licorice extract and sodium alginate.

Examples of the colorant include pigment-grade titanium oxide, zinc oxide, iron oxide, organic pigments, talc, sericite, mica, synthetic mica, chromium oxide, and gunjo.

In addition, powder may be blended to improve the feel and impart a make-up effect. Specifically, boron nitride, silica, alumina, aluminum hydroxide, metal soap, silicone powder, polymethylmethyl methacrylate. And so on.

As the additive, one type can be used alone, or two or more types can be used in combination. Further, the present invention is not limited to these, and known ingredients blended in external preparations for skin such as cosmetics and pharmaceuticals can be appropriately used.

[PH]
The external composition for skin of the present invention usually has a liquid property of pH 2.0 to 9.0, but is preferably pH 3 from the viewpoint of low irritation to the skin and mucous membranes and good skin usability. .0 to 8.5, more preferably pH 4.0 to 8.0, even more preferably pH 4.5 to 7.5, even more preferably pH 5.0 to 7.5.

[Manufacturing method of external composition for skin]
The method for producing the external composition for skin of the present invention is not particularly limited, and in addition to the above-mentioned components (A) to (C), the above-mentioned other useful components, other components, bases / carriers, additives and the like can be appropriately added. If necessary, it can be selected, blended, and emulsified as necessary according to a conventional method to produce the product.

[Properties / Formulation]
The properties of the external composition for skin of the present invention are not particularly limited, and may be liquid, fluid, or semi-solid. Examples of the formulation form include liquid preparations, suspensions, emulsions, creams, emulsions, ointments, gels, liniments, lotions, aerosols, non-woven fabrics impregnated with chemicals, sticks, and the like. It can be a formulation. Among them, emulsions, creams, emulsions, ointments, gels, lotions, sheets and sticks are preferable, and creams, emulsions, gels, lotions and sheets are particularly suitable. When an oily base and an aqueous base are contained, such as emulsions, creams, and ointments, either W / O type or O / W type may be used, but the feeling of use of the external composition for skin of the present invention ( The O / W type is more preferable from the viewpoint of stickiness, spread, moist feeling, freshness, penetration feeling, etc.).

[Use applications]
Specific uses for external compositions for pharmaceutical products or cosmetics include, for example, lotion, milky lotion, gel, cream, beauty liquid, sunscreen cosmetics, packs, masks, all-in-one gels, etc. Basic cosmetics such as hand creams, body lotions, wipes and body creams; and cleaning cosmetics such as wash pigments, hand soaps, makeup removers, body shampoos, shampoos, rinses, and treatments, BB creams, foundations, Face makeup cosmetics such as makeup base, lip cosmetics such as lip cream, lip liner, lip gel; hair rinse for hair, hair treatment, hair conditioner, hair gel, hair mousse, hair mist, hair lotion, styling agent, etc. Examples include hair cosmetics. Of these, external compositions for the skin are particularly preferable. That is, the external composition of the present invention can be a pharmaceutical, quasi-drug, or cosmetic external composition for skin. The formulation form of the external composition for skin is the same as that of the external composition of the present invention. In addition, the bases or carriers, additives, and active ingredients that can be used, and their preferred ones, are the same as in the case of the external composition of the present invention.

[container]
The external composition for skin of the present invention can be contained and used in a container having an appropriately selected shape and material according to the purpose of use and use. Specific examples of the container include a spray type, a bottle type, a tube type, a jar type, a dropper type, a dispenser type, a stick type, a pouch bag, and a cheer pack. Since the external composition for skin of the present invention can be used in a preferable state from the viewpoint of ease of removal from the container, it is possible to increase the degree of freedom in designing a formulation containing a high concentration of nicotinamide. That is, even a high-concentration nicotinamide-containing preparation can be easily used in a wide variety of containers such as sprays, bottles, tubes and dispensers as well as jars and sticks.

Examples of the material of the container include polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, and metal (aluminum, etc.). In addition, these materials are subjected to various coating treatments in consideration of strength, flexibility, weather resistance, stability of components, etc., and these materials are combined or laminated by, for example, mixing them. , Can be used as a container material. Of these, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ethylene vinyl alcohol resin, and metal (aluminum, etc.) are preferably used.

[How to use]
The external composition for skin of the present invention can be suitably used for the purpose of promoting blood circulation, anti-inflammatory and ceramide synthesis in anticipation of the physiological activity of nicotinamide. Furthermore, it can be expected to have whitening, anti-wrinkle, and anti-aging effects, and is useful as a multifunctional preparation including whitening agents and sunscreens. The external composition for skin of the present invention can be used in a known or commonly used dosage and administration in 1 to several divided doses per day depending on the intended use.

[Precipitation suppression method]
In another embodiment, the present invention can also provide a method for suppressing the precipitation of an external composition for skin containing (A) nicotinamide. Achievement of suppression of precipitation of external composition for skin by preparing external composition for skin containing (A) nicotinamide; (B) preservative; and (C) organic acid, organic acid salt, or amphoteric compound. can do.

As used herein, the term "precipitate" means, for example, a phenomenon in which a component appears as a solid regardless of the form of the external composition for skin of the present invention (for example, a solid precipitate, acicular crystals or a hazy cotton-like substance). It refers to substances). It can be a visible precipitate. Alternatively, it is also possible to detect precipitation and solution transparency that are difficult to detect visually with a turbidity meter and an ultraviolet visible infrared spectrophotometer (model V-770, manufactured by JASCO Corporation). For example, when the external composition for skin of the present invention is prepared as an aqueous composition, it is preferably colorless and transparent, but it may precipitate over time by a low temperature storage test. Precipitation suppression also includes preventing, delaying, and reducing such precipitation.

Next, the present invention will be specifically described with reference to Examples, but the present invention is not limited to the following Examples.

The components used in the examples are as follows. The numerical value in each table is the content of the component itself described in the component name.

Polyoxypropylene methylglucoside (10PO): Macbiobride MG-10P (manufactured by NOF CORPORATION)
Polyoxyethylene Polyoxypropylene Butyl Ether (17EO) (17PO): Unilube 50MB-26 (manufactured by NOF CORPORATION)
Polyoxyethylene Polyoxypropylene Glyceryl Ether (24EO) (24PO): Unilube 50TG-32 (manufactured by NOF CORPORATION)
Polyoxyethylene Polyoxypropylene Butyl Ether (37EO) (38PO): Unilube 50MB-168 (manufactured by NOF CORPORATION)
Polyoxybutylene polyoxyethylene polyoxypropylene methylglucoside: Wilbride MG2070 (manufactured by NOF CORPORATION)
Polyoxypropylene diglyceryl ether (14PO): SY-DP14 (manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.)
Polyoxypropylene diglyceryl ether (9PO): SY-DP9 (manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.)
2-Methylloyloxyethyl phosphorylcholine / butyl methacrylate copolymer: Lipidure-PMB (BG) (manufactured by NOF CORPORATION)
Polyoxypropylene sorbitol (25PO): Uniol HS-1600D (manufactured by NOF CORPORATION).

[Cryopreservation test]
The compositions shown in Tables 1 to 7 were prepared by a conventional method, and 20 mL of each sample was filled in a 20 mL glass bottle. These compositions were left to stand for 1 week in a constant temperature bath at 4 ° C., and the presence or absence of precipitation of crystals was visually confirmed.

The results are also shown in Tables 1 to 7. All figures in the table are mass%.

As shown in Tables 1 to 7, when the component (B) preservative and (C) an organic acid, an organic acid salt, a derivative of an organic acid, or an amphipathic component are blended in a comparative example, precipitation occurs. The problem was found that it would occur. On the other hand, in Examples, it was found that when (A) nicotinamide was further contained, precipitation over time was suppressed. In particular, as shown in Table 7, when tranexamic acid as a component (C-1) and a copolymer of 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate as a component (C-2) are added, the same precipitation occurs. An inhibitory effect was observed.

Further, the compositions of Examples shown in Tables 1 to 7 were also excellent in usability.

[Formulation example]
The external composition for skin of the present invention was prepared based on the formulations shown in Tables 8 to 28 below. The numerical value in the table means mass%.

In any of the preparation examples, a composition for external use on the skin, which does not precipitate over time and has a good usability, can be obtained.

Claims (6)

(A) Nicotinamide 3% by mass or more;
(B) Preservative; and (C) Divalent carboxylic acid ester, polyoxyalkylene glyceryl ether, polyoxyalkylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyoxypropyleneoxy Butylene alkyl ether, polyoxyalkylene sorbit, polyoxyalkylene erythritol ether, polyoxyalkylene pentaerythritol ether, polyoxyalkylene diglyceryl ether, polyoxyalkylene trimethyl propane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, poly One or more selected from the group consisting of oxyalkylene xylitol, polyoxyalkylene dipentaerythritol, polyoxyalkylene inositol, polyoxyalkylene sucrose ether, polyoxyalkylene trehalose ether, and polyoxyalkylene multitoll ether ; External composition to be contained:
(However, (1) the following lotion (ingredient) (%)
1.1,3-butylene glycol 10.0
2. 2. Glycerin 5.0
3. 3. Diglycerin 0.5
4. Remaining amount of purified water 5. Nicotinamide 6.0
6. Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol 0.5
7. Betaine 0.1
8. Erythritol 0.1
9. Methyl paraoxybenzoate 0.1
10. Disodium edetate 0.05
11. White fungus polysaccharide 0.01
12. Acrylic acid / alkyl methacrylate copolymer 0.1
13. Alcaligenes-producing polysaccharide 0.1
14. (PEG-240 / decyltetradeceth-20 / HDI) copolymer
0.1
15. Carbomer 0.1
16. Xanthan gum 0.1
17. Sodium hydroxide 0.03
18. Purified water 10.0
19. Polyoxyethylene hydrogenated castor oil isostearate 0.1
20. Astaxanthin 0.1
21. Polyoxyethylene polyoxypropylene decyltetradecyl ether 0.1
22. Ethanol 10.0
23. Menthol 0.01
24. Fragrance 0.2
(2) The following aqueous cleansing (ingredients) (%)
1. 1. Remaining amount of purified water 2. Citric acid 0.1
3. 3. Sodium citrate 0.1
4. Dipropylene glycol 15.0
5.1,3-butylene glycol 5.0
6. Glycerin 2.0
7. White fungus polysaccharide 0.01
8. Polyquaternium-51 0.5
9. Nicotinamide 4.0
10. Astaxanthin 0.1
11. Ethanol 1.0
12. Methyl paraoxybenzoate 0.1
13. PEG / PPG / Polybutylene Glycol-8 / 5/3 Glycerin 5.0
14. Polyoxyethylene glyceryl triisostearate (20EO) 1.0
15. Ascorbyl tetra2-hexyldecanoate 0.01
16. Polyoxyethylene coconut oil fatty acid monoethanolamide (10EO) 0.1
17. Polyoxyethylene polyoxypropylene decyltetradecyl ether 0.1
(3) A composition containing both arbutin and squalane,
And (4) composition containing agmatine or a salt thereof) The component (C) is polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene methyl glucoside, polyoxypropylene methyl glucoside, polyoxyethylene methyl. Glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene polyoxypropylene decyltetradecyl ether, polyoxypropylene sorbit, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether, Eikosan The external composition for skin according to claim 1, which is polyglyceryl-10 (diacid / tetradecanedioic acid), bisethoxydiglycol cyclohexanedicarboxylic acid, diethoxyethyl succinate, or diethylhexyl succinate. The component (B) is paraoxybenzoic acid ester, benzoic acid, benzoate, dehydroacetic acid, dehydroacetate, timol, isopropylmethylphenol, caprylhydroxamic acid, propynyl butylcarbamate iodide, propynyl iodide butylcarbamic acid. The skin according to any one of claims 1 or 2 , which is at least one selected from the group consisting of salts, propynyl butylcarbamic acid iodide, sorbic acid, sorbate, chlorobutanol, and methylisothiazolin. External composition. The composition for external use on the skin according to any one of claims 1 to 3, wherein the content of the component (A) is 3 to 10% by mass. The composition for external use on the skin according to any one of claims 1 to 4, wherein the content of the component (B) is 0.0001 to 6% by mass. The composition for external use on the skin according to any one of claims 1 to 5, wherein the content of the component (C) is 0.1 to 15% by mass.