JP6921288B1 - Oil-in-water emulsified composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oil-in-water emulsified composition which is less likely to cause a sticky feeling and gives a fresh feeling even when an amount of nicotinamide which gives a firmness to the skin is blended. An oil-in-water emulsified composition containing the following components (A) to (D), wherein the content of the component (A) is 0.1 to 5.4% by weight based on the total amount of the composition. thing. (A) Niacinamide (B) Polyglycerin fatty acid ester (C) Anionic surfactant (D) Water [Selection diagram] None

Description

The present invention relates to an oil-in-water emulsified composition containing nicotinamide.

One of the dosage forms of external preparations for skin such as cosmetics is the oil-in-water emulsifier type.
The oil-in-water emulsifier type is preferred as an external preparation for skin because the aqueous phase exists as a continuous phase and gives a fresh feel when used.

Nicotinamide is attracting attention as a component that improves skin conditions that deteriorate with age, such as wrinkles and firmness. However, when nicotinamide is added to an external preparation for skin, it has been regarded as a problem that a sticky feel occurs (Patent Document 1).

Special Table 2003-502435

As in Patent Document 1, nicotinamide has been blended into an oil-in-water emulsified composition, but it cannot be said that the sticky feeling can be satisfactorily suppressed.
In view of such a situation, the present invention provides an oil-in-water emulsified composition that does not cause a sticky feeling and gives a fresh feeling even if nicotinamide is added to the extent that a firmness-imparting effect is obtained on the skin. The challenge is to provide.

As a result of diligent research to solve the above problems, the present inventors have suppressed the stickiness of the oil-in-water emulsified composition containing a specific amount of nicotinic acid amide by combining a specific surfactant, and it is fresh. We came up with the idea of being able to give a feel, and completed the present invention.

That is, the present invention is as follows.
[1] An oil-in-water emulsified composition containing the following components (A) to (D), wherein the content of the component (A) is 0.1 to 5.4% by weight based on the total amount of the composition. ..
(A) Nicotinic acid amide (B) Polyglycerin fatty acid ester (C) Anionic surfactant (D) Water [2] Component (B) contains one molecule of polyglycerin having a degree of polymerization of 10 and 16 or more carbon atoms. The oil-in-water emulsified composition according to [1], which is a polyglycerin fatty acid ester formed by ester condensation of 2 to 5 fatty acids.
[3] The oil-in-water emulsified composition according to [1] or [2], wherein the content of the component (B) is 0.05 to 10% by weight based on the total amount of the composition.
[4] The oil-in-water type according to any one of [1] to [3], wherein the component (C) is one or more anionic surfactants selected from acyl lactate and fatty acid glyceryl sulfate. The oil-in-water emulsified composition according to any one of [1] to [4], wherein the content of the emulsifying composition [5] component (C) is 0.05 to 5% by weight based on the total amount of the composition. ..
[6] The oil-in-water emulsified composition according to any one of [1] to [5], further comprising the component (E) higher alcohol.
[7] The oil-in-water emulsified composition according to [6], wherein the component (E) is 0.05 to 5% by weight based on the total amount of the composition.
[8] The content weight ratio (A) / ((B) + (C)) of the component (A), the component (B), and the component (C) in the composition is 0.005 to 50, [1]. The oil-in-water emulsified composition according to any one of [7].
[9] The oil-in-water emulsified composition according to any one of [1] to [8], which is an external preparation for skin.

The oil-in-water emulsified composition of the present invention is less likely to cause a sticky feeling when used, and a fresh feeling can be obtained. In addition, the oil-in-water emulsified composition of the present invention is also excellent in stability over time and temperature. Furthermore, when applied to the skin, the action of nicotinamide can give a firm feeling to the back skin. Therefore, the present invention provides an oil-in-water emulsified composition suitable for the aspect of an external preparation for skin.

The oil-in-water emulsified composition of the present invention contains (A) nicotinamide.
Nicotinamide has the effect of imparting a firmness to the back skin when the composition is applied to the skin. The firmness is the feeling that the skin is elastic and pushes back against stress.

The content of (A) nicotinamide in the oil-in-water emulsified composition of the present invention is 0.1 to 5.4% by weight based on the total amount of the composition. By containing the composition in such a range, the composition does not become sticky and a fresh feel can be obtained. The content of nicotinamide is preferably 1 to 5.4% by weight, more preferably 3.5 to 5.4% by weight, based on the total amount of the composition. By containing the composition in such a range, it becomes easier to obtain a firm feeling on the skin after applying the composition.

The oil-in-water emulsified composition of the present invention contains (B) a polyglycerin fatty acid ester.
Here, the polyglycerin fatty acid ester is an ester of a branched or linear saturated or unsaturated fatty acid and polyglycerin, and the fatty acid has preferably 16 or more carbon atoms, more preferably 18 or more carbon atoms. .. The degree of polymerization of polyglycerin is not particularly limited, but 10 is particularly preferable. The number of fatty acids added is not particularly limited and may be mono, di-, tri-, or more, but 2 to 5 is preferable.
The HLB value of the polyglycerin fatty acid ester is not particularly limited, but those of 3 to 16 are preferable. In this specification, the HLB value refers to a value calculated from the Griffin formula.

Preferred examples of polyglycerin fatty acid esters are polyglyceryl dioleate, polyglyceryl trioleate, polyglyceryl tetraoleate, polyglyceryl pentaoleate, polyglyceryl dipalmitate, polyglyceryl tripalmitate, polyglyceryl tetrapalmitate, polyglyceryl pentapalmitate, and distearate. Examples thereof include polyglyceryl acid, polyglyceryl tristearate, polyglyceryl tetrastearate, polyglyceryl pentastearate, polyglyceryl diisostearate, polyglyceryl triisostearate, polyglyceryl tetraisostearate, and polyglyceryl pentaisostearate.
More preferable examples include polyglyceryl-10 tristearate, polyglyceryl-10 pentastearate, and polyglyceryl-10 pentaisostearate having a degree of polymerization of glycerin 10.

The content of the (B) polyglycerin fatty acid ester in the oil-in-water emulsified composition of the present invention is preferably 0.05 to 10% by weight, more preferably 0.2 to 5% by weight, based on the total amount of the composition. It is more preferably 0.5 to 2% by weight.
By containing it in such a range, it becomes easy to suppress the stickiness of the composition, and it becomes easy to improve the emulsification stability.

The oil-in-water emulsified composition of the present invention contains (C) an anionic surfactant.
The anionic surfactant is not particularly limited, but is, for example, acyl lactate (for example, sodium stearoyl lactate, sodium lauroyl lactate, etc.); fatty acid sequent (for example, sodium laurate, sodium palmitate, etc.); higher alkyl sulfate ester. Salts (eg, sodium lauryl sulfate, potassium lauryl sulfate, etc.); Alkyl ether sulfates (eg, POE lauryl sulfate triethanolamine, POE sodium lauryl sulfate, etc.); N-acylsulfonic acid (eg, sodium lauroyl sarcosin, etc.); Higher fatty acid amide sulfonates (eg, N-myristoyl-N-methyl taurine sodium, coconut oil fatty acid methyl taurid sodium, lauryl methyl taurid sodium, etc.); phosphate ester salts (POE oleyl ether sodium phosphate, POE stearyl ether) Phosphosuccinate (eg, sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); Alkylbenzene sulfonate (eg, linear dodecyl) Sodium benzene sulfonate, linadodecyl benzene sulfonic acid triethanolamine, linear dodecyl benzene sulfonic acid, etc.); Salts (eg, monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L-glutamate, etc.); sulfated oils (eg, funnel oil, etc.); POE alkyl ether carboxylic acids; POE alkylallyl Ether carboxylate; α-olefin sulfonate; higher fatty acid ester sulfonate; secondary alcohol sulfate ester salt; higher fatty acid alcoholuramide sulfate ester salt; sodium lauroyl monoethanolamide succinate; N-palmitoyl aspartate ditriethanol Amin; sodium caseinate and the like can be mentioned.
The HLB value of the anionic surfactant is not particularly limited, but one of 10 or more is preferable.

Of these, acyl lactate is more preferable, and the acyl group preferably has 12 or more carbon atoms, and examples thereof include sodium stearoyl lactate, sodium lauroyl lactate, and sodium isostearoyl lactate.
Fatty acid glyceryl sulfate is also more preferable as an anionic surfactant, and higher fatty acid is preferable as such fatty acid, and for example, coconut oil fatty acid sodium glyceryl sulfate (coconut glyceryl sulfate), hardened coconut oil fatty acid sodium glyceryl sulfate and the like are particularly preferable. Be done.

The content of the (C) anionic surfactant in the oil-in-water emulsified composition of the present invention is preferably 0.05 to 5% by weight, more preferably 0.1 to 1% by weight, based on the total amount of the composition. %, More preferably 0.25 to 0.45% by weight.
By containing it in such a range, it becomes easy to suppress the stickiness of the composition, and it becomes easy to improve the emulsification stability.

The weight ratio of the component (B) polyglycerin fatty acid ester in the composition to the (C) anionic surfactant is not particularly limited, but is preferably (B) :( C) = 1: 100 to 200: 1. Yes, more preferably 1: 1 to 8: 1.
Further, the weight ratio (A) / ((B) + (C)) of each of the components (A) nicotinic acid amide, (B) polyglycerin fatty acid ester, and (C) anionic surfactant in the composition. Is preferably 0.005 to 50, more preferably 0.1 to 25, and even more preferably 0.5 to 10.
By containing it in such a range, it becomes easy to suppress the stickiness of the composition, and it becomes easy to improve the emulsification stability.

Oil-in-water emulsion composition of the present invention is to further suppress the stickiness of the composition, from the viewpoint of improving Ri by the emulsion stability, further (E) preferably contains a higher alcohol.
The higher alcohol is not particularly limited, but a saturated or unsaturated, linear or branched monohydric alcohol having 8 or more carbon atoms is preferable. Specifically, cetyl alcohol (cetyl alcohol), behenyl alcohol, palmitrail alcohol, heptadecanol, 1-heptadecanol, stearyl alcohol, isostearyl alcohol, ellaidyl alcohol, oleyl alcohol, linoleil alcohol, elelide linoleil alcohol. , Linolenyl alcohol, elelide linolenyl alcohol, ricinorail alcohol, nonadecil alcohol, arachidyl alcohol, heneicosanol, behenyl alcohol, elcil alcohol and the like are preferable.

The content of the higher alcohol (E) in the composition of the present invention is 0. 0 to 5% by mass is preferable, 0.1 to 4% by mass is more preferable, and 0.5 to 3% by mass is further preferable.

The dosage form of the composition of the present invention is an oil-in-water emulsified type.
In the present invention, the dosage form is not particularly limited as long as the outermost phase is the aqueous phase, and may be W / O / W type or (O ₁ + O ₂ ) / W type in addition to O / W type. ..

The composition of the present invention usually contains an aqueous phase component and an oil phase component.
As an aqueous phase component, the oil-in-water emulsified composition of the present invention contains (D) water. Further, the aqueous phase component may be a component that dissolves in water at 25 to 90 ° C. in addition to water. Usually, a surfactant containing (A) nicotinic acid amide, and (B) polyglycerin fatty acid ester and (C) anionic surfactant is also included in the aqueous phase component. The oil phase component is not limited to an oil agent, and may include powder or the like, and may be a component that is suspended in water at 25 to 90 ° C., allowed to stand for 1 hour, and then phase-separated from water.
In the emulsified composition of the present invention, the weight ratio of the contents of the aqueous phase component and the oil phase component is not particularly limited, but is preferably 99: 1 to 50:50, more preferably 95: 5 to 70:40. be.

The oil-in-water emulsified composition of the present invention can be used with a fresh feel without stickiness while blending an effective amount of nicotinamide. In addition, Ru sense of firmness is applied to the skin after application. Furthermore, it has excellent emulsification stability even after storage over time.

Therefore, the composition of the present invention can be preferably applied to an external preparation for skin.
The external preparation for skin is preferably in the form of cosmetics or quasi-drugs, and more preferably skin care cosmetics, sunscreen cosmetics, and make-up cosmetics.

The oil-in-water emulsified composition of the present invention can be produced according to a conventional method.

The cosmetic of the present invention may optionally contain other ingredients normally used in cosmetics as long as the effects of the present invention are not impaired. Such optional components include, for example, oils, other alcohols, ethers, powders, clay minerals, moisturizers, other surfactants, metal ion preservatives, pearling agents, amino acids, organic amines, polymer emulsions, pH adjustments. Examples include agents, vitamins, antioxidants, preservatives, water-soluble polymers, fragrances, and various active ingredients.

Examples of the oil agent include silicone oil, polar oil, natural oil, hydrocarbon oil and the like.

Polar oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, and lactic acid as synthetic ester oils. Cetyl, myristyl lactate, lanolin acetate, isosetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearyl, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl dicaprate Glycol, diisostearyl malate, glyceryl di-2-heptyl undecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentanerythritol tetra-2-ethylhexylate, tri-2-ethylhexanoic acid Glyceryl, Trimethylol Propane triisostearate, Cetyl 2-Ethylhexanoate, 2-Ethylhexyl Palmitate, Glyceryl Trimyristinate, Glyceride Tri-2-Heptylundecanoic Acid, Himasi Oil Fatty Acid Methyl Estel, Oleic Acid Oil, Setostearyl Alcohol , Acetglyceride, 2-Heptylundecyl palmitate, Diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, Di-2-heptylundecyl adipate, Ethyllaurate, Di-2-sebatate Ethylhexyl, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebatate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, octylmethoxycinnamate And so on.

Natural oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern ka oil, castor oil, flaxseed oil, and sausage oil. Flower oil, cotton seed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnamon oil, Japanese millet oil, jojoba oil, germ oil, sunflower oil, triglycerin, glyceryl trioctanoate, triisopalmitin Examples include glyceryl acid acid.

Examples of the hydrocarbon oil include isododecane, isohexadecane, squalane, hydrogenated poly (C6-12) olefin, hydrogenated polyisobutene and the like.

Other alcohols include, for example, monohydric alcohols such as ethanol; ethylene glycol, 1,3-butylene glycol, trimethylene glycol, 1,2-butylene glycol, propylene glycol, dipropylene glycol, propanediol, 1,2. -Pentanediol, 3-methyl-1,3-butanediol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, etc. 2 Valuable alcohols; trivalent alcohols such as trimethylolpropane; tetravalent alcohols such as pentaerythritol; pentahydric alcohols such as xylitol; polyhydric alcohol polymers such as triglycerin, tetraglycerin, polyglycerin; starch-degrading sugars Glycols such as reduced alcohols;
Ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl Alcohol alkyl ethers such as ether;
Diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol Alcohol alkyl ethers such as methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether;
Glycerin monoalkyl ethers such as xyl alcohol, ceracyl alcohol, and batyl alcohol;
Alcohol polymers such as diethylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, polyethylene glycol;
Glysolid; Tetrahydrofurfuryl alcohol; POE-Tetrahydrofurfuryl alcohol; POP-butyl ether; POP / POE-butyl ether; Tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphoric acid; POP / POE-pentane Examples include erythritol ether and the like.

As ether, in addition to those corresponding to the above alcohols
Ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol methyl ethyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether Acetate, ethylene glycol diazibate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether Examples include acetate.

The shape of the powder is not particularly limited, such as spherical, needle-shaped, and plate-shaped. For example, inorganic powder (for example, talc, kaolin, mica, silk mica (serisite), white mica, gold mica, synthetic mica, Red mica, black mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, alumina, zeolite, barium sulfate, Calcined calcium sulfate (baked sekko), calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, boron nitride, etc.; Organic powder (for example, polyamide resin powder (nylon powder), polyethylene powder, poly (meth) methyl acrylate powder, polystyrene) Powders, styrene and acrylic acid copolymer resin powders, silicone resin powders, benzoguanamine resin powders, polytetrafluoride ethylene powders, cellulose powders, etc.); Metal soaps (eg, zinc myristate, calcium palmitate, aluminum stearate) Inorganic white pigments (eg, titanium dioxide, zinc oxide, etc.); Inorganic red pigments (eg, iron oxide (Bengala), iron titanate, etc.); Inorganic brown pigments (eg, γ-iron oxide, etc.); Inorganic yellow Pigments (eg, yellow iron oxide, yellow clay, etc.); Inorganic black pigments (eg, black iron oxide, lower titanium oxide, etc.); Inorganic purple pigments (eg, mango violet, cobalt violet, etc.); Inorganic green pigments (For example, chromium oxide, chromium hydroxide, cobalt titanate, etc.); Inorganic blue pigments (for example, ultramarine blue, dark blue, etc.); Pearl pigments (for example, titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc) , Colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, etc.); Metal powder pigments (eg, aluminum powder, copper powder, etc.); Organic pigments such as zirconium, barium or aluminum lake (eg, red 201, red 202, etc.) , Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, and Blue 404. Red 3, Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Green 3 No. and Blue No. 1 etc.); Natural pigments (For example, chlorophyll, β-carotene, etc.) and the like.

Examples of the organically modified clay mineral include hectorite, montmorillonite, saponite, hectorite, bentonite, smectite and the like. Further, organically modified clay minerals obtained by treating these with organic cations may be used. , Hectorite, dioctadecyldimethylammonium salt-modified montmorillonite, octadecyldimethylbenzylammonium salt-modified montmorillonite, dihexadecyldimethylammonium salt-modified montmorillonite, dimethyldistearylammonium smectite and the like.

Moisturizers include, for example, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, short chain soluble collagen, diglycerin (EO) PO. Additives, Izayoi rose extract, Hyaluronic acid extract, Merilot extract and the like can be mentioned.

Other surfactants include cationic surfactants, amphoteric surfactants, and nonionic surfactants.
However, surfactants other than (B) polyglycerin fatty acid ester and (C) anionic surfactant are preferably used as long as the effects of the present invention are not impaired.

Examples of the cationic surfactant include an alkyltrimethylammonium salt (for example, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); an alkylpyridinium salt (for example, cetylpyridinium chloride, etc.); a distearyldimethylammonium chloride dialkyldimethylammonium salt. Polychloride (N, N'-dimethyl-
3,5-Methylene piperidinium); alkyl quaternary ammonium salt; alkyldimethylbenzylammonium salt; alkylisoquinolinium salt; dialkylmoriphonium salt; POE alkylamine; alkylamine salt; polyamine fatty acid derivative; amyl alcohol fatty acid Derivatives; benzylconium chloride; benzethonium chloride and the like can be mentioned.

Examples of the amphoteric tenside include imidazoline-based amphoteric tenside agents (for example, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazolin sodium, 2-cocoyl-2-imidazolinium hydroki. Side-1-carboxyethyroxy disodium salt, etc.); Betaine-based surfactants (eg, 2-heptadecyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amide betaine) , Sulfobetaine, etc.) and the like.

Nonionic surfactants include polyether-modified silicones (eg, polyethylene glycol-10 dimethicone, polyethylene glycol-12 dimethicone, etc.); polyglycerin-modified silicones (eg, polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 poly, etc.). Dimethylsiloxyethyl dimethicone, etc.); sorbitan fatty acid esters (eg, sorbitan monooleate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, Sorbitane trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, etc.); , Α, α'-glyceryl pyroglutamate oleate, glycerin malic acid monostearate, etc.); propylene glycol fatty acid esters (eg, propylene glycol monostearate, etc.); POE castor oil / cured castor oil derivative (POE castor oil, etc.) POE-hardened castor oil, etc.); Examples thereof include non-hydrophilic nonionic surfactants such as glycerin alkyl ether. Also, POE sorbitan fatty acid esters (eg, POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan tetraoleate, etc.); POE sorbit fatty acid esters (eg, POE sorbit monolaurate, POE sorbit monooleate, etc.). POE sorbit pentaoleate, POE sorbit monostearate, etc.); POE glycerin fatty acid esters (eg, POE glycerin monostearate, POE glycerin monoisostearate, POE glycerin triisostearate, etc.); POE fatty acids Esters (eg, POE distearate, POE monodiolate, ethylene glycol distearate, etc.); POE alkyl ethers (eg, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, etc. POE cholestanol ethers, etc.); POE alkylphenyl ethers (eg, POE nonylphenyl ethers, etc.); Pluronic types (eg, Pluronic, etc.); POE / POP alkyl ethers (eg, POE / POP cetyl ethers, POE / POP, etc.) -2-Decil Tetradecyl ether, POE / POP monobutyl ether, POE / POP hydrogenated lanolin, POE / POP glycerin ether, etc.); Tetra POE / Tetra POP ethylenediamine condensates (for example, Tetronic); Castile oil derivatives (eg POE castor oil, POE cured castor oil, POE cured castor oil monoisostearate, POE cured castor oil triisostearate, POE cured castor oil monopyroglutamic acid monoisostearic acid diester, POE cured castor oil maleine Acids, etc.); POE mitsuro / lanolin derivatives (eg, POE sorbit honeys, etc.); Arcanolamides (eg, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE fatty acid amides; sucrose fatty acid esters; other alkyl glycosides; alkyl ethoxydimethylamine oxides; hydrophilic nonionic surfactants such as trioleyl phosphate.

Examples of the metal ion sequestering agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate. , Sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate and the like.

Examples of the pearlizing agent include glycol distearate, titanium mica and the like.

Examples of amino acids include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like. Examples of the amino acid derivative include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl β-alanine sodium, glutathione, pyrrolidone carboxylic acid and the like.

Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol and the like. Can be mentioned.

Examples of the polymer emulsion include an acrylic resin emulsion, an ethyl polyacrylate emulsion, an acrylic resin solution, a polyacrylic alkyl ester emulsion, a polyvinyl acetate resin emulsion, and a natural rubber latex.

Examples of the pH adjuster include buffers such as lactic acid-sodium lactate, citrate-sodium citrate, and succinic acid-sodium succinate, and are usually used for adjusting the pH of the internal phase (aqueous component). Used.

Examples of vitamins include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin and the like.

Examples of antioxidants include tocopherols, dibutylhydroxytoluene (BHT), butylhydroxyanisole, pyrosulfate, gallic acid ester, phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, and fumaric acid. , Kephaline, hexametaphosphate, phytic acid, ethylenediamine tetraacetic acid and the like.

Examples of the preservative include parabens, phenoxyethanol and the like.

Examples of the water-soluble polymer include plant-based polymers (for example, Arabic gum, tragacant gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, canten, quince seed (malmero), algae colloid (cassaw extract), starch (rice). , Corn, potato, wheat), glycyrrhizinic acid); microbial macromolecules (eg, xanthan gum, dextran, succinoglucan, burran, etc.); animal macromolecules (eg, collagen, casein, albumin, gelatin, etc.), etc. Water-soluble polymer,
Cellulose-based polymers (eg, carboxymethyl starch, methylhydroxypropyl starch, etc.); Cellulose-based polymers (hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose stearoxyether, sodium cellulose sulfate, carboxy) Methyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulosic powder, etc.); Semi-synthetic water-soluble polymers such as alginic acid-based polymers (eg, sodium alginate, propylene glycol alginate, etc.),
Vinyl-based polymers (for example, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, carboxyvinyl polymers, etc.); Polyoxyethylene-based polymers (for example, polyethylene glycol 20,000, 40,000, 60,000, etc.); Acrylic-based polymers Polymers (eg, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethylene imines; synthetic water-soluble polymers such as cationic polymers.

Examples of various active ingredients include anti-inflammatory agents (eg, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokithiol, zinc oxide, allantin, etc.); whitening agents (eg, placenta extract, yukinoshita extract, arbutin, etc.); Various extracts (eg, Oubaku, Ouren, Shikon, Shakuyaku, Senburi, Birch, Sage, Biwa, Carrot, Aloe, Zeniaoi, Iris, Grape, Yokuinin, Hechima, Yuri, Saffron, Senkyu, Shokyu, Otogirisou, Ononis, Garlic , Tocopherol, chimpi, touki, seaweed, etc.), activator (eg, royal jelly, photosensitizer, cholesterol derivative, etc.); , Zingeron, cantalistinki, ictamol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclanderate, cinnaridine, trazoline, acetylcholine, verapamil, cepharanthin, γ-orizanol, etc.; For example, sulfur, thiantoll, etc.); anti-inflammatory agents (eg, tranexamic acid, thiotaurine, hypotaurine, etc.) and the like.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to the following Examples as long as the gist thereof is not exceeded.

<Manufacturing example and evaluation>
With the formulation components shown in Tables 1 to 3, the oil phase component and the aqueous phase component are each heated to 70 ° C. to dissolve them, the oil phase is added to the aqueous phase component, and the oil phase is emulsified while stirring with a homomixer to obtain oil in water. A mold emulsification composition was prepared.
(Stability)
The obtained composition was stored at 40 ° C. for 4 weeks, and then the appearance was visually observed, and the stability was evaluated according to the following criteria.
⊚: No separation was observed and it was stable.
◯: Slight separation has occurred, but there is no problem with quality.
Δ: Some separation occurred.
X: A clear visual separation was observed.

In addition, each of the 10 expert panels took 0.5 g of each prepared composition on the back of the hand and sensory-evaluated whether it felt sticky or firm on the back skin, and the evaluation results were based on the following criteria. And said.
(A feeling of stickiness)
⊚: More than 9 out of 10 answered that they were not sticky.
◯: More than 7 out of 10 responded that they were “not sticky”.
Δ: 5 or more out of 10 responded that they were “not sticky”.
X: 4 out of 10 respondents answered that they were not sticky.
(Tightness of the back skin)
⊚: More than 9 out of 10 responded that they felt firmness in the back skin.
◯: More than 7 out of 10 responded that they felt “tension on the back skin”.
Δ: 5 or more out of 10 responded that they felt “tension on the back skin”.
X: 4 out of 10 respondents answered that they felt firmness in the back skin.
The evaluation results are also shown in Tables 1 to 3.

The oil-in-water emulsified composition of the present invention is less likely to cause a sticky feeling when used, and a fresh feeling can be obtained. In addition, the oil-in-water emulsified composition of the present invention is also excellent in stability over time and temperature. Furthermore, when applied to the skin, the action of nicotinamide can give a firm feeling to the back skin.
The oil-in-water emulsified composition of the present invention is very useful in industry because it is suitable for the mode of an external preparation for skin and can meet the demand of consumers and the like.

Claims (9)

An oil-in-water emulsified composition containing the following components (A) to (D), wherein the content of the component (A) is 3.5 to 5.4% by weight based on the total amount of the composition.
(A) Nicotinamide (B) Polyglycerin fatty acid ester with HLB of 5.5 or less (C) Anionic surfactant (D) Water The oil-in-water type according to claim 1, wherein the component (B) is a polyglycerin fatty acid ester obtained by ester-condensing one molecule of polyglycerin having a degree of polymerization of 10 and 2 to 5 molecules of a fatty acid having 16 or more carbon atoms. Esterizing composition. The oil-in-water emulsified composition according to claim 1 or 2, wherein the content of the component (B) is 0.05 to 10% by weight based on the total amount of the composition. The oil-in-water emulsified composition according to any one of claims 1 to 3, wherein the component (C) is one or more anionic surfactants selected from acyl lactate and fatty acid glyceryl sulfate. .. The oil-in-water emulsified composition according to any one of claims 1 to 4, wherein the content of the component (C) is 0.05 to 5% by weight based on the total amount of the composition. The oil-in-water emulsified composition according to any one of claims 1 to 5, further comprising the component (E) higher alcohol. The oil-in-water emulsified composition according to claim 6, wherein the content of the component (E) is 0.05 to 5% by weight based on the total amount of the composition. Content weight ratio of component (A), component (B), and component (C) in the composition (A) / ((B) + (C)
)) Is 0.005 to 50. The oil-in-water emulsified composition according to any one of claims 1 to 7. The oil-in-water emulsified composition according to any one of claims 1 to 8, which is an external preparation for skin.